Alexandre Louvet, Julien Labreuche, Thong Dao, Thierry Thévenot, Frédéric Oberti, Christophe Bureau, Thierry Paupard, Eric Nguyen-Khac, Anne Minello, Brigitte Bernard-Chabert, Rodolphe Anty, Faustine Wartel, Nicolas Carbonell, Georges-Philippe Pageaux, Marie-Noelle Hilleret, Romain Moirand, Pierre Nahon, Camille Potey, Alain Duhamel, Philippe Mathurin
IMPORTANCE: The benefits of prophylactic antibiotics for hospitalized patients with severe alcohol-related hepatitis are unclear. OBJECTIVE: To determine the efficacy of amoxicillin-clavulanate, compared with placebo, on mortality in patients hospitalized with severe alcohol-related hepatitis and treated with prednisolone. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized, double-blind clinical trial among patients with biopsy-proven severe alcohol-related hepatitis (Maddrey function score ≥32 and Model for End-stage Liver Disease [MELD] score ≥21) from June 13, 2015, to May 24, 2019, in 25 centers in France and Belgium...
May 9, 2023: JAMA