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https://www.readbyqxmd.com/read/29197645/the-impact-of-iatrogenic-glottic-atresia-due-to-photodynamic-therapy-for-laryngeal-cancer-a-report-of-two-cases
#1
Seiji Hosokawa, Satoru Takebayashi, Hiroyuki Mineta
Photodynamic therapy (PDT) is a minimally invasive therapy used in the treatment of premalignant and malignant diseases, including head and neck carcinomas. It can be applied before or after chemotherapy, irradiation, or surgery. Unlike irradiation and surgery, it can be repeated many times at the same site, and it is also associated with better cosmetic and functional outcomes [1]. We have treated 10 patients with laryngeal carcinomas with PDT since 1998, and herein we describe two such patients who developed vocal cord adhesion due to PDT...
November 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29147004/dose-de-escalation-to-the-normal-larynx-using-conformal-radiotherapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-t1-t2-glottic-cancer
#2
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137654/conventional-fractionation-should-not-be-the-standard-of-care-for-t2-glottic-cancer
#3
Lynne M Dixon, Catriona M Douglas, Shazril Imran Shaukat, Kate Garcez, Lip Wai Lee, Andrew J Sykes, David Thomson, Nicholas J Slevin
BACKGROUND: The aim of this study was to report outcomes and late toxicity following hypofractionated accelerated radiotherapy for T2 glottic cancers. We highlight the importance of hypofractionated treatments with shorter overall treatment times, in improving outcomes for T2 glottic cancers. We also compare the biologically effective dose of hypofractionated regimes, with conventional fractionation. METHODS: One hundred twelve patients with T2 glottic cancer were treated between January 1999 and December 2005...
November 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29135033/primary-and-salvage-laser-surgery-of-341-glottic-cancers-comparison-of-treatment-outcomes-between-university-head-neck-tertiary-referral-center-and-local-head-neck-department
#4
Piotr Winiarski, Artur Lewandowski, Grażyna Greczka, Jacek Banaszewski, Hanna Klimza, Małgorzata Wierzbicka
OBJECTIVE: The main goal was to compare the clinical data of patients with T1 and T2 glottic cancer treated with CO2 transoral laser microlaryngoscopy (TLM) in the Tertiary Referral University Department of Otolaryngology, Head Neck Surgery, Poznan and the local Department of Otolaryngology, Oncology and Maxillofacial Surgery, Bydgoszcz. MATERIAL AND METHODS: Unified databases for the 7-year period January 2005-December 2011 were created to compare these two cohorts...
November 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29121261/re-hypofractionated-radiotherapy-for-patients-with-early-stage-glottic-cancer-patterns-of-care-and-survival
#5
Jens Overgaard
No abstract text is available yet for this article.
November 7, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29108356/radiotherapy-for-t3n0-glottic-carcinoma-without-cord-fixation-elective-nodal-irradiation-or-not
#6
Ryo Toya, Ryuji Murakami, Daizo Murakami, Tetsuo Saito, Tomohiko Matsuyama, Yutaka Toya, Yasuyuki Yamashita, Natsuo Oya
Background: Although the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. Materials and Methods: We retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098372/radiological-tumor-thickness-as-a-risk-factor-for-local-recurrence-in-early-glottic-cancer-treated-with-laser-cordectomy
#7
Ho-Jin Son, Yoon Se Lee, Ja Yoon Ku, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: Despite the excellent prognosis of early glottic cancer (T1-T2), the significance of preoperatively measured tumor thickness has not been elucidated. We evaluated the role of tumor thickness measured using computed tomography (CT) as a predictive factor for recurrence of early glottic cancer after transoral laser microsurgery (TLM). METHODS: The medical records of 134 patients who were diagnosed with early glottic squamous cell carcinoma and underwent TLM were reviewed...
November 2, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29075995/objective-and-self-evaluation-voice-analysis-after-transoral-laser-cordectomy-and-radiotherapy-in-t1a-t1b-glottic-cancer
#8
Nicola Lombardo, Teodoro Aragona, Said Alsayyad, Girolamo Pelaia, Rosa Terracciano, Rocco Savino
Voice quality outcome becomes an important factor in the choice of the therapeutic option. The differences between radiotherapy and laser cordectomy have been extensively debated in the literature. We analyzed the vocal outcomes after carbon dioxide (CO2) laser cordectomy and radiotherapy treatment for T1a-b early glottic cancer by means of objective and subjective voice evaluation. A retrospective study was performed on 56 cancer patients, 30 treated with cordectomy and 26 with radiotherapy. All patients underwent laser cordectomy which was performed under general anesthesia using a surgical microscope in laryngeal suspension...
October 26, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29054118/efficacy-of-laryngectomy-alone-for-treatment-of-locally-advanced-laryngeal-cancer-a-stage-and-subsite-specific-survival-analysis
#9
B P Cervenka, S Rao, D G Farwell, A F Bewley
OBJECTIVE: Total laryngectomy is a well-established treatment for locally advanced laryngeal cancer. Evidence for the benefit of post-operative radiotherapy after laryngectomy in patients with locally advanced primaries and N0 or N1 nodal disease is limited. This study aimed to determine whether total laryngectomy alone is adequate therapy for certain patient subgroups with locally advanced laryngeal cancer. DESIGN: We performed a retrospective survival analysis of patients in the surveillance epidemiology and end results (SEER) database with locally advanced laryngeal cancer between 2004 and 2012...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29049434/survival-outcomes-for-patients-with-t3n0m0-squamous-cell-carcinoma-of-the-glottic-larynx
#10
Huaising C Ko, Paul M Harari, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Randall J Kimple, Matthew E Witek
Importance: Radiotherapy (RT)-based organ preservation approaches for patients with advanced laryngeal cancer have been established stepwise through prospective randomized clinical trials. However, broad adoption of these approaches has stimulated discussion about long-term results challenging their applicability in a heterogeneous patient population, most recently for patients with T3 disease. Objective: To define outcomes in patients with clinical T3N0M0 glottic laryngeal cancer treated with definitive surgical and RT-based approaches...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28988971/voice-outcomes-after-radiotherapy-treatment-for-early-glottic-cancer-long-term-follow-up
#11
Megan Watson, Allison Drosdowsky, Jacqui Frowen, June Corry
OBJECTIVES: The aim of this study was to investigate long-term voice outcomes and voice-related quality of life (QOL) for early glottic cancer treated with radiotherapy. STUDY DESIGN: Long-term exploratory follow-up study of a prospective patient cohort comparing outcomes at a mean of 11 years postradiotherapy with the original 1-year posttreatment results. METHOD: Eight patients completed voice tasks for auditory perception and acoustic and aerodynamic measures...
October 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28975857/characteristics-of-speech-production-in-patients-with-t1-glottic-cancer-who-underwent-laser-cordectomy-or-radiotherapy
#12
Yong Tae Hong, Min Ju Park, Ki Hwan Hong
PURPOSE: Laser cordectomy (LC) or radiotherapy (RT) is often recommended in the early stage of laryngeal cancer. We conducted perceptual and acoustic analysis to compare sustained vowel and stop consonants since there is no article evaluating both the sustained vowel and stop consonants. Eventually, we might determine which management is superior in terms of speech production. SUBJECTS AND METHODS: A total of 28 patients who underwent LC and RT for early T1 glottic cancer were selected...
October 4, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/28904716/-supracricoid-partial-laryngectomy-scpl-with-either-cricohyoidoepiglottopexy-chep-our-experience-with-16-cases
#13
Bouchaib Hemmaoui, Mohamed Sahli, Noureddine Errami, Ahmed Rouihi, Mohamed Habib Bahalou, Ilias Benchaifai, Amine Ennouali, Sara Britel, Ismail Nakkabi, Ali Jahidi, Mohamed Zalagh, Saloua Ouaraini, Fouad Benariba
Partial laryngectomy with either cricohyoidoepiglottopexy (CHEP) are mainly used to treat glottic cancers becuse they ensure a satisfactory preservation of physiological functions and satisfactory local carcinologic control. Our study aimed to analyze the functional and carcinologic results of this surgical technique. We conducted a retrospective study of patients undergoing partial laryngectomy with either cricohyoidoepiglottopexy in our Hospital between 2011 and 2014. We analyzed the epidemiological data, the surgical peculiarities, the functional outcomes and the carcinologic control of the disease...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28898958/radiotherapy-for-laryngeal-cancer-technical-aspects-and-alternate-fractionation
#14
Hideya Yamazaki, Gen Suzuki, Satoaki Nakamura, Ken Yoshida, Koji Konishi, Teruki Teshima, Kazuhiko Ogawa
Early laryngeal, especially glottic, cancer is a good candidate for radiotherapy because obvious early symptoms (e.g. hoarseness) make earlier treatment possible and with highly successful localized control. This type of cancer is also a good model for exploring the basic principles of radiation oncology and several key findings (e.g. dose, fractionation, field size, patient fixation, and overall treatment time) have been noted. For example, unintended poor outcomes have been reported during transition from 60Cobalt to linear accelerator installation in the 1960s, with usage of higher energy photons causing poor dose distribution...
July 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28895160/oncologic-outcomes-of-ktp-laser-surgery-versus-radiation-for-t1-glottic-carcinoma
#15
Jamal Ahmed, Ahmed Sherif Gabr Ibrahim, Laura M Freedman, David E Rosow
OBJECTIVES/HYPOTHESIS: To characterize outcomes for patients who underwent transoral microsurgery with potassium titanyl phosphate (KTP) laser resection of early glottic cancers and to compare outcomes with patients who received external beam radiation therapy. STUDY DESIGN: Retrospective cohort study. METHODS: The history of patients with T1 glottic carcinoma treated with curative primary radiation or transoral KTP laser resection was reviewed...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28895157/laryngeal-exposure-and-margin-status-in-glottic-cancer-treated-by-transoral-laser-microsurgery
#16
Cesare Piazza, Alberto Paderno, Paola Grazioli, Francesca Del Bon, Nausica Montalto, Pietro Perotti, Riccardo Morello, Marta Filauro, Piero Nicolai, Giorgio Peretti
OBJECTIVE: Laryngeal exposure is one of the most limiting factors in transoral laser microsurgery (TLM) for glottic cancer. We evaluated the correlation between the degree of laryngeal exposure, as assessed by an easy previously described scoring tool (Laryngoscore), and histopathologic surgical margin status after TLM. STUDY DESIGN: Prospective evaluation of 147 patients affected by Tis-T2 glottic cancer treated by TLM with curative intent between January 2012 and April 2016...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28882936/ganglioneuroma-of-the-retropharyngeal-space-in-a-patient-with-glottic-cancer
#17
Raquel Baptista Dias, Duarte Rosa, Miguel Rito, Alexandra Borges
We describe the case of a 71-year-old man with a ganglioneuroma of the retropharyngeal space. The patient presented with a submucosal bulge of the left oropharyngeal wall during follow-up examination of a treated vocal cord carcinoma. CT and MRI revealed a non-specific, well-defined retropharyngeal soft tissue lesion. Positron emission tomography-CT did not show relevant metabolic activity, excluding the hypothesis of metastatic nodal disease. Surgical biopsy of the lesion was compatible with ganglioneuroma...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28873031/surgical-treatment-for-early-stage-glottic-carcinoma-with-involvement-of-the-anterior-commissure
#18
Philipp Wolber, David Schwarz, Thoralf Stange, Magdalene Ortmann, Matthias Balk, Andreas Anagiotos, Antoniu-Oreste Gostian
Objective Assessment of the value of transoral laser microsurgery (TLM) compared with open surgery (OS) for early stage squamous cell carcinoma of the glottic larynx with special regard to involvement of the anterior commissure (AC). Study Design Case series with chart review. Setting Tertiary care otolaryngology clinic. Subjects and Methods Review of clinicopathological data of all patients with previously untreated T1a, T1b, and T2 glottic squamous cell carcinoma of the larynx who were consecutively enrolled over a 10-year period (January 1, 1992, to December 31, 2002)...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28797446/patterns-of-fractionation-for-patients-with-t2n0m0-glottic-larynx-cancer-undergoing-definitive-radiotherapy-in-the-united-states
#19
William A Stokes, Priscilla K Stumpf, Bernard L Jones, Patrick J Blatchford, Sana D Karam, Ryan M Lanning, David Raben
OBJECTIVES: Among patients with T2N0M0 glottic larynx cancer undergoing definitive radiotherapy, recent retrospective and prospective data have suggested improved outcomes with altered fractionation over conventional fractionation (CFxn). We sought to characterize national fractionation patterns and to compare outcomes among them. MATERIALS AND METHODS: We queried the National Cancer Database for T2N0M0 squamous cell carcinomas of the glottis diagnosed from 2004-2014 and managed with definitive radiotherapy...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28771444/radiotherapy-for-t3n0-glottic-carcinoma-without-cord-fixation-elective-nodal-irradiation-or-not
#20
Ryo Toya, Ryuji Murakami, Daizo Murakami, Tetsuo Saito, Tomohiko Matsuyama, Yutaka Toya, Yasuyuki Yamashita, Natsuo Oya
BACKGROUND: Although the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. MATERIALS AND METHODS: We retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation...
July 18, 2017: Oncotarget
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