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glottic cancer

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https://www.readbyqxmd.com/read/29446476/the-role-of-human-papillomavirus-in-laryngeal-cancer-in-southern-china
#1
Eddy Wh Lam, Michael Mh Chan, Cynthia Kc Wai, Chi Man Ngai, Zigui Chen, Martin Cs Wong, Apple Cm Yeung, Joanna Hm Tong, Amy Bw Chan, K F To, Paul Ks Chan
Objective Delineate the role of human papillomavirus (HPV) in laryngeal cancer in Southern Chinese. Study Design A retrospective cross-sectional study. Setting A major otorhinolaryngology referral center in Hong Kong. Subjects and Methods Eighty-five Chinese patients with histology-confirmed laryngeal squamous cell carcinoma (LSCC) diagnosed between 2005 and 2010 were examined for the status of HPV by PCR, and the expression of p16 and p53 by immunohistochemistry. The HPV, p16 and p53 findings were correlated with clinicopathological features, recurrence and 5-year survival...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29416454/a-randomized-controlled-trial-comparing-c-mac-d-blade-and-macintosh-laryngoscope-for-nasotracheal-intubation-in-patients-undergoing-surgeries-for-head-and-neck-cancer
#2
Hrishikesh Hazarika, Anudeep Saxena, Pradeep Meshram, Ajay Kumar Bhargava
Purpose: Several devices are available to take care of difficult airway, but C-MAC D-Blade has scant evidence of its use in nasotracheal intubation in a difficult airway scenario. Aims and Objectives: We compared the C-MAC D-Blade videolaryngoscope™, and the standard Macintosh laryngoscope for nasal intubation in patients with difficult airways selected by El-Ganzouri risk index using parameters of time and attempts required for intubation, glottic view in terms of Cormack-Lehane grade, ease of intubation, success rate, use of accessory maneuvers, incidence of complications, and hemodynamic changes...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29401241/results-of-a-multi-institutional-randomized-non-inferiority-phase-3-trial-of-accelerated-fractionation-versus-standard-fractionation-in-radiation-therapy-for-t1-2n0m0-glottic-cancer-japan-clinical-oncology-group-study-jcog0701
#3
T Kodaira, Y Kagami, T Shibata, N Shikama, Y Nishimura, S Ishikura, K Nakamura, Y Saito, Y Matsumoto, T Teshima, Y Ito, T Akimoto, K Nakata, T Toshiyasu, K Nakagawa, Y Nagata, T Nishimura, T Uno, M Kataoka, A Yorozu, M Hiraoka
Background: We assessed the non-inferiority of accelerated fractionation (AF) (2.4 Gy/fraction) compared with standard fractionation (SF) (2 Gy/fraction) regarding progression-free survival (PFS) in patients with T1-2N0M0 glottic cancer (GC). Patients and Methods: In this multi-institutional, randomized, phase 3 trial, patients were enrolled from 32 Japanese institutions. Key inclusion criteria were GC T1 - 2N0M0, age 20 - 80, Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1, and adequate organ function...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29401237/pre-emptive-glottic-enlargement-before-laryngotracheal-surgery-in-patients-at-high-risk-for-postoperative-bilateral-vocal-fold-paralysis
#4
Thomas Schweiger, Konrad Hoetzenecker, Imme Roesner, Berit Schneider-Stickler, Doris-Maria Denk-Linnert, Walter Klepetko
OBJECTIVES: Bilateral vocal fold paralysis (VFP) is a severe complication after laryngotracheal (LT) surgery. The reduced glottic opening leads to significant respiratory distress immediately after the operation and requires the placement of a tracheostomy in most cases. Patients with a pre-existing unilateral VFP or expected recurrent nerve resection are at the highest risk for glottic failure. These patients might benefit from a pre-emptive glottic enlargement before LT surgery. METHODS: We performed a retrospective review of patients who received a pre-emptive glottis enlargement before LT surgery at the Medical University of Vienna from October 2011 to December 2016...
February 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29391895/high-expression-of-c-met-and-egfr-is-associated-with-poor-survival-of-patients-with-glottic-laryngeal-squamous-cell-carcinoma
#5
Mei Jiang, Hui Zhang, He Xiao, Zhimin Zhang, Dan Que, Jia Luo, Jian Li, Bijing Mao, Yuanyuan Chen, Meilin Lan, Ge Wang, Hualiang Xiao
The present study was undertaken to explore the association between the expression of hepatocyte growth factor receptor (c-Met) and epidermal growth factor receptor (EGFR) with clinicopathological factors and survival status, to obtain prognostic biomarkers in patients with glottis laryngeal squamous cell carcinoma (GLSCC). The expression status of c-Met and EGFR protein was analyzed in 71 archival laryngeal cancer samples by immunohistochemistry. Statistical methods, including univariate and multivariate Cox regression analysis, were used to determine risk factors of progression...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29373328/nature-and-role-of-surgical-margins-in-transoral-laser-microsurgery-for-early-and-intermediate-glottic-cancer
#6
Ivana Fiz, Jan Constantin Koelmel, Christian Sittel
PURPOSE OF REVIEW: Summarize recent findings regarding the impact of margin status on oncologic outcomes and organ preservation, as well as evaluate possible management policies of close and positive margins after transoral laser microsurgery (TLM) for Tis-T2 glottic carcinomas. RECENT FINDINGS: Impact of margin status on survival rates remains controversial, whereas some authors found close and positive margins to be independent risk factors for recurrence and poorer survival rates, others did not find any significant variations compared with negative ones...
January 25, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29368893/-laryngeal-disease-endoscopic-characterization-of-1493-procedures-based-on-age
#7
José Luis Che-Morales, Esperanza Figueroa-Hurtado, Arturo Cortes-Télles
BACKGROUND: Based on international epidemiology, some laryngeal diseases could be more frequent at certain ages. The objective was to describe endoscopic findings in patients through distinct decades of age in a laryngoscopy facility. METHODS: retrospective and descriptive study; clinical and endoscopic records were collected from 1493 procedures performed between 2009 and 2015, and organized in five groups of age for analysis. Differences among them were analyzed by chi squared and ANOVA...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29314074/efficacy-of-type-i-thyroplasty-after-endoscopic-cordectomy-for-early-stage-glottic-cancer-literature-review
#8
Caitlin Bertelsen, Lindsay Reder
OBJECTIVE: As phonomicrosurgical techniques have evolved, endoscopic cordectomy (EC) has been used more commonly for early-stage glottic cancer. Patients undergoing more extensive surgery often experience significant postoperative dysphonia for which there is no standard treatment. Surgical options include injection laryngoplasty and thyroplasty. We reviewed the literature to evaluate the efficacy of thyroplasty after EC. METHODS: A comprehensive literature search was conducted to identify studies of adults undergoing thyroplasty for dysphonia after EC for glottic cancer...
January 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29291278/treatment-preferences-in-patients-with-early-glottic-cancer
#9
Yda van Loon, Martine Hendriksma, Ton P M Langeveld, Martin A de Jong, Rob J Baatenburg de Jong, Elisabeth V Sjögren
OBJECTIVE: For early glottic carcinoma, the 2 main treatment modalities are radiotherapy (RT) and transoral CO2 laser microsurgery (TLM). The aim of this study was to investigate treatment preferences and considerations in patients with early glottic carcinoma (T1-T2) who were given a choice between TLM and RT. SUBJECTS AND METHODS: Patients with early glottic cancer (suspected or confirmed extended T1 or limited T2) were counseled by an ENT-surgeon. A subset of 32 patients was also counseled by a radiotherapist...
December 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29229412/long-term-voice-outcome-following-radiation-versus-laser-microsurgery-in-early-glottic-cancer
#10
Yue Ma, Rebecca Green, Daniel McCabe, Leanne Goldberg, Peak Woo
OBJECTIVES: Long-term voice outcome (LTVO) after radiation (XRT) or trans-oral laser microsurgery (TLM) is unclear. This study is a multi-modality analysis of LTVO following XRT or TLM in patients with early glottic cancer. We hypothesize that as compared with TLM, LTVO is worse in the XRT group because of progressive fibrosis in the glottic tissue MATERIAL AND METHODS: One hundred and two patients with early glottic carcinoma (carcinoma in situ, T1, T2) were included. Multi-modality voice analyses were performed with self-perception using Voice Handicap Index-10, objective analysis using Analysis of Dysphonia in Speech and Voice Software (Cepstral Spectral Index of Dysphonia score for Consensus Auditory-Perceptual Evaluation of Voice sentences), and perceptual rating by two blinded speech language pathologists (GRBAS scale)...
December 8, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29197645/the-impact-of-iatrogenic-glottic-atresia-due-to-photodynamic-therapy-for-laryngeal-cancer-a-report-of-two-cases
#11
Seiji Hosokawa, Satoru Takebayashi, Hiroyuki Mineta
Photodynamic therapy (PDT) is a minimally invasive therapy used in the treatment of premalignant and malignant diseases, including head and neck carcinomas. It can be applied before or after chemotherapy, irradiation, or surgery. Unlike irradiation and surgery, it can be repeated many times at the same site, and it is also associated with better cosmetic and functional outcomes [1]. We have treated 10 patients with laryngeal carcinomas with PDT since 1998, and herein we describe two such patients who developed vocal cord adhesion due to PDT...
November 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29147004/dose-de-escalation-to-the-normal-larynx-using-conformal-radiotherapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-t1-t2-glottic-cancer
#12
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137654/conventional-fractionation-should-not-be-the-standard-of-care-for-t2-glottic-cancer
#13
Lynne M Dixon, Catriona M Douglas, Shazril Imran Shaukat, Kate Garcez, Lip Wai Lee, Andrew J Sykes, David Thomson, Nicholas J Slevin
BACKGROUND: The aim of this study was to report outcomes and late toxicity following hypofractionated accelerated radiotherapy for T2 glottic cancers. We highlight the importance of hypofractionated treatments with shorter overall treatment times, in improving outcomes for T2 glottic cancers. We also compare the biologically effective dose of hypofractionated regimes, with conventional fractionation. METHODS: One hundred twelve patients with T2 glottic cancer were treated between January 1999 and December 2005...
November 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29135033/primary-and-salvage-laser-surgery-of-341-glottic-cancers-comparison-of-treatment-outcomes-between-university-head-neck-tertiary-referral-center-and-local-head-neck-department
#14
Piotr Winiarski, Artur Lewandowski, Grażyna Greczka, Jacek Banaszewski, Hanna Klimza, Małgorzata Wierzbicka
OBJECTIVE: The main goal was to compare the clinical data of patients with T1 and T2 glottic cancer treated with CO2 transoral laser microlaryngoscopy (TLM) in the Tertiary Referral University Department of Otolaryngology, Head Neck Surgery, Poznan and the local Department of Otolaryngology, Oncology and Maxillofacial Surgery, Bydgoszcz. MATERIAL AND METHODS: Unified databases for the 7-year period January 2005-December 2011 were created to compare these two cohorts...
November 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29121261/re-hypofractionated-radiotherapy-for-patients-with-early-stage-glottic-cancer-patterns-of-care-and-survival
#15
Jens Overgaard
No abstract text is available yet for this article.
November 7, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29108356/radiotherapy-for-t3n0-glottic-carcinoma-without-cord-fixation-elective-nodal-irradiation-or-not
#16
Ryo Toya, Ryuji Murakami, Daizo Murakami, Tetsuo Saito, Tomohiko Matsuyama, Yutaka Toya, Yasuyuki Yamashita, Natsuo Oya
Background: Although the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. Materials and Methods: We retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098372/radiological-tumor-thickness-as-a-risk-factor-for-local-recurrence-in-early-glottic-cancer-treated-with-laser-cordectomy
#17
Ho-Jin Son, Yoon Se Lee, Ja Yoon Ku, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: Despite the excellent prognosis of early glottic cancer (T1-T2), the significance of preoperatively measured tumor thickness has not been elucidated. We evaluated the role of tumor thickness measured using computed tomography (CT) as a predictive factor for recurrence of early glottic cancer after transoral laser microsurgery (TLM). METHODS: The medical records of 134 patients who were diagnosed with early glottic squamous cell carcinoma and underwent TLM were reviewed...
November 2, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29075995/objective-and-self-evaluation-voice-analysis-after-transoral-laser-cordectomy-and-radiotherapy-in-t1a-t1b-glottic-cancer
#18
Nicola Lombardo, Teodoro Aragona, Said Alsayyad, Girolamo Pelaia, Rosa Terracciano, Rocco Savino
Voice quality outcome becomes an important factor in the choice of the therapeutic option. The differences between radiotherapy and laser cordectomy have been extensively debated in the literature. We analyzed the vocal outcomes after carbon dioxide (CO2) laser cordectomy and radiotherapy treatment for T1a-b early glottic cancer by means of objective and subjective voice evaluation. A retrospective study was performed on 56 cancer patients, 30 treated with cordectomy and 26 with radiotherapy. All patients underwent laser cordectomy which was performed under general anesthesia using a surgical microscope in laryngeal suspension...
October 26, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29054118/efficacy-of-laryngectomy-alone-for-treatment-of-locally-advanced-laryngeal-cancer-a-stage-and-subsite-specific-survival-analysis
#19
B P Cervenka, S Rao, D G Farwell, A F Bewley
OBJECTIVE: Total laryngectomy is a well-established treatment for locally advanced laryngeal cancer. Evidence for the benefit of post-operative radiotherapy after laryngectomy in patients with locally advanced primaries and N0 or N1 nodal disease is limited. This study aimed to determine whether total laryngectomy alone is adequate therapy for certain patient subgroups with locally advanced laryngeal cancer. DESIGN: We performed a retrospective survival analysis of patients in the surveillance epidemiology and end results (SEER) database with locally advanced laryngeal cancer between 2004 and 2012...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29049434/survival-outcomes-for-patients-with-t3n0m0-squamous-cell-carcinoma-of-the-glottic-larynx
#20
Huaising C Ko, Paul M Harari, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Randall J Kimple, Matthew E Witek
Importance: Radiotherapy (RT)-based organ preservation approaches for patients with advanced laryngeal cancer have been established stepwise through prospective randomized clinical trials. However, broad adoption of these approaches has stimulated discussion about long-term results challenging their applicability in a heterogeneous patient population, most recently for patients with T3 disease. Objective: To define outcomes in patients with clinical T3N0M0 glottic laryngeal cancer treated with definitive surgical and RT-based approaches...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
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