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glottic cancer

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https://www.readbyqxmd.com/read/27902867/predictive-factors-and-treatment-outcome-of-laryngeal-carcinoma-recurrence
#1
Aaro Haapaniemi, Janne Väisänen, Timo Atula, Olli-Pekka Alho, Antti Mäkitie, Petri Koivunen
BACKGROUND: Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence. METHODS: A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy (n = 316) was analyzed. RESULTS: Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment...
November 30, 2016: Head & Neck
https://www.readbyqxmd.com/read/27863075/transoral-laser-microsurgery-versus-radiotherapy-for-t2-glottic-squamous-cell-carcinoma-a-systematic-review-of-local-control-outcomes
#2
L Warner, K Lee, J J Homer
BACKGROUND: Systematic reviews comparing treatment of early glottic cancer with transoral surgery or radiotherapy demonstrate similar oncological outcomes. Most studies of "early stage" laryngeal cancer include Tis, T1a, T1b and T2 cases. The data is dominated by patients with T1 and Tis tumours, although extrapolating these results and applying them for T2 cases may be inappropriate. No previous systematic reviews have focused on T2 cancers as a separate group. OBJECTIVE OF REVIEW: This review compares local control outcomes for T2 glottic squamous cell carcinoma, treated with transoral microsurgery or external beam radiotherapy...
November 10, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27846642/-stomal-cancer-recurrency-a-clinic-pathological-consideration
#3
S Teutsch, M Bas, H Bier, A Knopf
Objectives: Analysis of pre-operative tracheostomy and circumjacent tumour free margins as risk factors in the development of stomal recurrent disease after (pharyngo)laryngectomy. Material and Methods: 124 patients after (pharyngo)laryngectomy were analyzed for disease related data and tumour samples were analyzed for tumour free margins. The overall cohort was divided into patients with/withour pre-operative tracheostomy. Results: 18 patients suffered from recurrent disease (10 stomal, 8 distant metastases)...
November 15, 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27833963/anterior-commissure-laryngeal-neoplasm-endoscopic-management
#4
Nicolae Constantin Balica, Mărioara Poenaru, Eugen HoraŢiu Ştefănescu, Eugen Radu Boia, Caius Ion Doroş, Flavia Baderca, Octavian Mazilu
The CO2 laser surgery represents a treatment method of laryngeal bicordal and anterior commissure glottic cancer T1b, T2, N0. In Department of ENT, Timisoara, Romania, during 1.01.2001-31.12.2011 were analyzed 781 files from patients with laryngeal neoplasm. One hundred twenty-seven patients presented the tumor that involved both vocal cords and anterior commissure, stages T1b, T2 and T3. Therapeutic options included CO2 laser microsurgical excision for 55 (43.30%) patients, frontolateral hemilaryngectomy for 16 (12...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27812699/appropriate-treatment-of-t3-glottic-cancer
#5
Luca D'Ascanio, Marco Pappacena, Fabio Piazza
No abstract text is available yet for this article.
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27812697/appropriate-treatment-of-t3-glottic-cancer-reply
#6
Maha Al-Gilani, Bruce Haughey, Jay F Piccirillo
No abstract text is available yet for this article.
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27778345/evaluating-organ-preservation-outcome-as-treatment-endpoint-for-t1an0-glottic-cancer
#7
Tsu-Hui Hubert Low, David Yeh, Tina Zhang, Rakhna Araslanova, J Alex Hammond, David Palma, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, John Yoo, Anthony Nichols, Kevin Fung
OBJECTIVES/HYPOTHESIS: Common endpoints in reporting the outcomes for early glottic cancer do not highlight the importance of organ preservation. We evaluated the treatment outcomes among patients with T1aN0 laryngeal cancer with laryngectomy-free disease-specific survival (LFS-DSS), which is defined as time to total laryngectomy or time to death from cancer cause, against all other endpoints. STUDY DESIGN: Outcome research on an institutional database. METHODS: A retrospective review covered all consecutive patients from 2003 to 2013...
October 25, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27765542/dosimetric-comparison-of-helical-tomotherapy-intensity-modulated-radiation-therapy-volumetric-modulated-arc-therapy-and-3-dimensional-conformal-therapy-for-the-treatment-of-t1n0-glottic-cancer
#8
Kemal Ekici, Eda K Pepele, Bahaddin Yaprak, Oztun Temelli, Aysun F Eraslan, Nadir Kucuk, Ayse Y Altınok, Pelin A Sut, Ozlem D Alpak, Cemil Colak, Alpaslan Mayadagli
Various radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT...
October 17, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27727509/early-glottic-cancer-and-difficult-laryngoscopy-flexible-endoscopic-diode-laryngeal-laser-assisted-surgery-a-pilot-study-of-an-oncologically-safe-tool
#9
LETTER
P D Karkos, M Stavrakas, K Markou
No abstract text is available yet for this article.
December 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27716797/risk-of-recurrence-in-laryngeal-cancer
#10
Jesper Brandstorp-Boesen, Ragnhild Sørum Falk, Jan Folkvard Evensen, Morten Boysen, Kjell Brøndbo
A cohort study was undertaken to analyze the risk of recurrence among 1616 patients with primary squamous cell carcinoma of the larynx from 1983 to 2010 at a single, tertiary academic center in Oslo, Norway. The cohort was followed from the date of diagnosis to September 2011. Competing risk regression analysis assessed the association between various risk factors and the risk of recurrence, where death was considered a competing event. Recurrence was observed in 368 patients (23%) during the study period. The majority (71%) of recurrences involved the location of the primary tumor...
2016: PloS One
https://www.readbyqxmd.com/read/27709626/long-term-quality-of-life-after-transoral-laser-microsurgery-for-laryngeal-carcinoma
#11
Meritxell Valls-Mateus, Alexis Ortega, José Luis Blanch, Francesc Sabater, Manuel Bernal-Sprekelsen, Isabel Vilaseca
BACKGROUND AND OBJECTIVES: Previous studies showed good short-term Quality of life (QOL) after Transoral Laser Microsurgery (TLM) for laryngeal cancer. Here, we aimed to evaluate QOL after TLM in the long-term. METHODS: Prospective longitudinal study. Sixty-two consecutive disease-free patients were evaluated using UW-QOL v4 and SF-12 questionnaires, 1 and 5 years after TLM. Changes over time were assessed according to age, location, and tumor size. Long-term VHI-10 was also evaluated...
October 6, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27688116/prospective-swallowing-outcomes-after-imrt-for-oropharyngeal-cancer-dosimetric-correlations-in-a-population-based-cohort
#12
Gordon Z Guo, Keith R Sutherland, Candace Myers, Pascal Lambert, Shaun K Loewen, Harvey C Quon
OBJECTIVES: To identify dose constraints to preserve swallowing after head and neck (H&N) radiotherapy using prospectively collected functional outcomes. MATERIALS AND METHODS: Stage III-IV oropharyngeal cancer patients were prospectively evaluated using the Royal Brisbane Hospital Outcome Measure for Swallowing and Performance Status Scale for H&N Cancer Patients at pre-treatment and 3, 6, 12, and 24months after intensity-modulated radiotherapy. Dosimetric parameters were correlated with swallowing function...
October 2016: Oral Oncology
https://www.readbyqxmd.com/read/27687404/fiberoptic-nasopharyngoscopy-for-evaluating-a-potentially-difficult-airway-in-a-patient-with-elevated-intracranial-pressure
#13
Lakshmi N Kurnutala, Gurneet Sandhu, Sergio D Bergese
A 62-year-old man with a left temporal lobe tumor was scheduled for a semiurgent craniotomy for tumor excision. Previously, the patient had a laryngeal carcinoma that was resected and treated with chemotherapy and radiotherapy and a history of laryngeal biopsy with awake fiberoptic intubation. Because a difficult airway was anticipated, awake fiberoptic nasopharyngoscopy of the airway was performed under topical anesthesia in the operating room. This revealed a narrow glottic opening with no supraglottic pathology or friable tissue...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27674444/dose-de-escalation-to-the-normal-larynx-using-conformal-radiation-therapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-the-treatment-of-t1-t2-glottic-cancer
#14
J W Kim, H S Choi, I J Lee
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27599684/-head-and-neck-intensity-modulated-radiation-therapy-normal-tissues-dose-constraints-pharyngeal-constrictor-muscles-and-larynx
#15
P Graff, V Woisard, S Racadot, J Thariat, Y Pointreau
Radio-induced pharyngolaryngeal chronic disorders may challenge the quality of life of head and neck cancer long survivors. Many anatomic structures have been identified as potentially impaired by irradiation and responsible for laryngeal edema, dysphonia and dysphagia. Some dose constraints might be plausible such as keeping the mean dose to the pharyngeal constrictor muscles under 50 to 55Gy, the mean dose to the supra-glottic larynx under 40 to 45Gy and, if feasible, the mean dose to the glottic larynx under 20Gy...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27578610/management-of-primary-t1-t4-glottic-squamous-cell-carcinoma-by-transoral-laser-microsurgery
#16
Andrew T Day, Parul Sinha, Brian Nussenbaum, Dorina Kallogjeri, Bruce H Haughey
OBJECTIVES/HYPOTHESIS: Evaluate the oncologic outcomes of patients with early and select advanced primary glottic squamous cell carcinoma (SCCa) managed by transoral laser microsurgery (TLM). STUDY DESIGN: Retrospective cohort study. METHODS: Ninety cases of TLM-managed primary glottic SCCa were identified retrospectively using a prospectively collected database. RESULTS: Outcomes of patients with pTis-pT2a disease (n = 65) and pT2b-pT4a disease (n = 25) were, respectively: 5-year local control, 86...
August 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27556786/accuracy-of-software-assisted-contour-propagation-from-planning-ct-to-cone-beam-ct-in-head-and-neck-radiotherapy
#17
Christian A Hvid, Ulrik V Elstrøm, Kenneth Jensen, Markus Alber, Cai Grau
BACKGROUND: Autocontouring improves workflow in computed tomography (CT)-based dose planning, but could also potentially play a role for optimal use of daily cone beam CT (CBCT) in adaptive radiotherapy. This study aims to determine the accuracy of a deformable image registration (DIR) algorithm for organs at risk (OAR) in the neck region, when applied to CBCT. MATERIAL AND METHODS: For 30 head and neck cancer (HNC) patients 14 OARs including parotid glands, swallowing structures and spinal cord were delineated...
November 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27556660/definitive-radiotherapy-for-squamous-cell-carcinoma-of-the-glottic-larynx
#18
William M Mendenhall, Roi Dagan, Curtis M Bryant, Robert J Amdur, Anthony A Mancuso
BACKGROUND: Depending on the extent of disease, squamous cell carcinoma (SCC) of the glottis is managed with surgery, radiotherapy (RT), or a combination of these modalities. Patients with advanced disease may receive concomitant chemotherapy in conjunction with definitive or postoperative RT. METHODS: The treatment policies of the University of Florida and patient outcomes are reviewed. RESULTS: The likelihood of cure after RT for carcinoma in situ (Tis) to T2 glottic SCC varies from 70% to 94% depending on tumor stage...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27521037/-radiotherapy-of-larynx-cancers
#19
Y Pointreau, C Lafond, F Legouté, P Trémolières, S Servagi-Vernat, P Giraud, P Maingon, G Calais, M Lapeyre
Intensity-modulated radiotherapy is the gold standard in the treatment of larynx cancers (except T1 glottic tumour). Early T1 and T2 tumours may be treated by exclusive radiation or surgery. For tumours requiring total laryngectomy (T2 or T3), induction chemotherapy followed by exclusive radiotherapy or concurrent chemoradiotherapy is possible. For T4 tumour, surgery must be proposed. The treatment of lymph nodes is based on the initial treatment of the primary tumour. In non-surgical procedure, in case of sequential radiotherapy, the curative dose is 70Gy and the prophylactic dose is 50Gy...
September 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27508129/challenges-in-the-management-of-laryngeal-stenosis
#20
Satish Nair, Ajith Nilakantan, Amit Sood, Atul Gupta, Abhishek Gupta
Laryngeal stenosis is one of the most complex and challenging problems in the field of head and neck surgery. The management involves a multidisciplinary approach with multiple complex procedures. In this study we discuss our experience of laryngeal stenosis with regards to patient characteristics, cause and management. A retrospective analysis of 35 patients of laryngeal stenosis treated at a tertiary care centre was evaluated. Inclusion criteria were all patients with laryngeal stenosis who required surgical intervention...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
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