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https://www.readbyqxmd.com/read/28193302/outcomes-of-transoral-laser-microsurgical-management-of-t1b-stage-glottic-cancer
#1
J A Song, M H Rigby, J Trites, R D Hart, S M Taylor
OBJECTIVE: This study aimed to evaluate the oncological and voice outcomes of transoral laser microsurgery for tumour stage T1b stage glottic cancer patients. METHODS: A prospective cohort study in a tertiary care head and neck cancer centre included tumour-node-metastasis stage T1bN0M0 glottic cancer patients scheduled to undergo transoral laser microsurgery from January 2002 until June 2014. Kaplan-Meier five-year analyses of local control, overall survival, disease-specific survival and laryngeal preservation were performed...
February 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28177326/supracricoid-laryngectomy-for-recurrent-laryngeal-cancer-after-chemoradiotherapy-a-systematic-review-and-meta-analysis
#2
C A Leone, P Capasso, D Topazio, G Russo
Residual or recurrent laryngeal cancer after irradiation is a difficult clinical problem with a rate that ranges from 13% to 36% of cases. Supracricoid laryngectomy (SCL) with cricohyoidopexy (CHP) or cricohyoidoepiglottopexy (CHEP) provide reliable oncological and functional results for selected primary and recurrent patients with glottic and supraglottic carcinomas. We conducted a systematic review and meta-analysis to assess the oncological and functional outcomes of patients treated with open partial horizontal laryngectomy types IIa and IIb (CHEP, CHP) in terms of the recurrence of squamocellular cancer of the larynx after radiotherapy failure...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28169863/supratracheal-partial-laryngectomy-indications-oncologic-and-functional-results
#3
Giovanni Succo, Marco Fantini, Giuseppe Rizzotto
PURPOSE OF REVIEW: To describe current evidence about supratracheal laryngectomies, focusing on indications, contraindications, oncologic results, functional outcomes and side-effects of this 'extreme' function-sparing surgical approach to laryngeal cancer. RECENT FINDINGS: In the latest years, some studies have analyzed oncologic and functional results of open partial supratracheal laryngectomy, a surgical approach whose modern technique was recently described...
February 4, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28166396/elmo3-predicts-poor-outcome-in-t1-laryngeal-cancer
#4
Georg Haymerle, Lorenz Kadletz, Robert Wiebringhaus, Bahar Golabi, Michael Mildner, Dietmar Thurnher, Gregor Heiduschka
OBJECTIVES: Despite the excellent overall survival of 92-97% in early glottic cancer, recurrence rates of 13-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) has been described as prognostic marker in lung cancer patients. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome. DESIGN, SETTING AND PARTICIPANT: 48 patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analyzed...
February 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28153526/two-stage-co2-laser-assisted-bilateral-cordectomy-for-ct1b-glottic-carcinoma
#5
Andy Bertolin, Marco Lionello, Gianni Salis, Giuseppe Rizzotto, Marco Lucioni
PURPOSE: The aim of the present paper was to investigate the oncological safety of two-stage bilateral cordectomy for the treatment of cT1b glottic SCC, and to compare its oncological outcome and synechia development rate with those of single-stage procedures. MATERIALS AND METHODS: A retrospective cohort study was performed at the Otolaryngology Unit of Vittorio Veneto Laryngeal Cancer Center (Italy). The prognostic significance of clinical, pathological and surgical factors was also investigated, in terms of recurrence rate and disease-free survival, in a univariate statistical setting...
January 18, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28122353/matched-pair-analysis-of-survival-in-patients-with-poorly-differentiated-versus-well-differentiated-glottic-squamous-cell-carcinoma
#6
Ping Chen, Wenbin Yu, Junwei Huang, Hongbo Xu, Guojun Li, Xiaohong Chen, Zhigang Huang
To compare survival outcomes between patients with poorly differentiated versus well-differentiated glottic squamous cell carcinoma (GSCC). Fifty-five patients with well-differentiated newly diagnosed GSCC were pair-matched to 55 patients with poorly differentiated GSCC according to age, sex, year of diagnosis, overall stage, treatment (surgery type, neck dissection, surgical margin, and chemoradiation), smoking, and alcohol use. Survival analysis was performed using Kaplan-Meier estimates, and matched-pair survival was estimated using the Cox proportional hazards regression model...
January 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28110846/prognostic-role-of-margin-status-in-open-and-co2-laser-cordectomy-for-t1a-t1b-glottic-cancer
#7
Vincenzo Landolfo, Carmine Fernando Gervasio, Giuseppe Riva, Massimiliano Garzaro, Rita Audisio, Giancarlo Pecorari, Roberto Albera
INTRODUCTION: Cordectomy by laringofissure and transoral laser surgery has been proposed for the treatment of early glottic cancer. OBJECTIVES: The aim of this retrospective study was to evaluate the prognostic value of margin status in 162 consecutive cases of early glottic carcinoma (Tis-T1) treated with CO2 laser endoscopic surgery (Group A) or laryngofissure cordectomy (Group B), and to compare the oncologic and functional results. METHODS: Clinical prognostic factors, local recurrence rate according to margin status, overall survival and disease-free survival were analyzed...
December 24, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28069084/transoral-laser-resection-of-glottic-carcinoma-what-is-the-significance-of-anterior-commissure-involvement
#8
K A Stephenson, J J Fagan
BACKGROUND: The optimal management of glottic carcinoma involving the anterior commissure is controversial. METHOD: A retrospective analysis was conducted of 76 patients with glottic squamous cell carcinoma treated by transoral carbon dioxide laser resection by a single surgeon. RESULTS: Sixty-three patients (with tumour stage Tis-T3) were eligible for inclusion. Thirty patients had involvement of the anterior commissure; these patients were significantly more likely to have either uncertain or positive margins (63...
February 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28028607/transoral-laser-microsurgery-for-t1b-glottic-cancer-review-of-51-cases
#9
Bernhard G Weiss, Friedrich Ihler, Yiannis Pilavakis, Hendrik A Wolff, Martin Canis, Christian Welz, Wolfgang Steiner
For the treatment of T1b glottic carcinoma, different treatment options, such as transoral laser microsurgery, open surgical techniques, and primary radiotherapy, are under discussion. In this context, the aim of the present study was to describe oncologic results and complication rates of transoral laser microsurgery in treatment of T1b glottic carcinoma. This is a retrospective unicenter chart review of patients treated at an academic tertiary referral center between 1986 and 2006. Fifty-one previously untreated T1b cases were exclusively treated by transoral laser microsurgery and included into this study, 47 were male, and 4 were female...
December 27, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28008195/a-multicenter-survey-of-stage-t1-glottic-cancer-treated-with-radiotherapy-delivered-in-2-25-gy-fractions-in-clinical-practice-an-initial-5-year-analysis
#10
Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa
The purpose of this study was to evaluate the acute and late toxicity as well as local control (LC) in T1 glottic cancer (GC) patients treated with hypofractionated radiotherapy (RT) in clinical practice. The Tokai Study Group for Therapeutic Radiology and Oncology started RT treatment with a dose of 2.25 Gy for T1 GC in 2011. Ten institutions combined data from 104 patients with T1 squamous cell carcinoma between 2011 and 2015. In total, 104 patients with T1 GC were irradiated with a standard radiation dose of 63 Gy in 28 fractions...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28003696/comparative-randomised-study-of-glidescope-%C3%A2-video-laryngoscope-versus-flexible-fibre-optic-bronchoscope-for-awake-nasal-intubation-of-oropharyngeal-cancer-patients-with-anticipated-difficult-intubation
#11
Essam Abd El-Halim Mahran, Mohamed Elsayed Hassan
BACKGROUND AND AIMS: Awake flexible fibre-optic bronchoscope (FFS) is the standard method of intubation in difficult airway in oral cancer patients. We decided to evaluate GlideScope(®) video laryngoscope (GL) for intubation as compared to the standard FFS for nasal intubation in such patients. METHODS: After the ethical committee approval, we included 54 oropharyngeal cancer patients divided randomly into two equal groups: Group G and Group F. After pre-medication and pre-oxygenation, awake nasal intubation was performed using GL in Group G and FFS in Group F...
December 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27966287/transoral-laser-microsurgery-versus-radiation-therapy-in-the-management-of-t1-and-t2-laryngeal-glottic-carcinoma-which-modality-is-cost-effective-within-the-uk
#12
M Prettyjohns, S Winter, C Kerawala, V Paleri
OBJECTIVES: To identify the most cost-effective treatment strategy in patients with early stage (T1 and T2) cancers of the laryngeal glottis. DESIGN: A Markov decision model populated using data from updated systematic reviews and meta-analyses, with attributable costs from NHS sources. Data on local control and mortality were obtained from updates of existing systematic reviews conducted for the NICE guideline on cancer of the upper aerodigestive tract. Procedure costs were sourced from NHS reference costs 2013/14 by applying tariffs associated with the appropriate health resource group code SETTING: The UK National Health Service...
December 14, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27966051/transoral-laser-microsurgery-versus-radiotherapy-for-t1-glottic-carcinoma-a-systematic-review-and-meta-analysis
#13
Hai-Lan Mo, Jie Li, Xiang Yang, Feng Zhang, Jun-Wei Xiong, Zhi-Ling Yang, Jian Tan, Bing Li
Transoral laser microsurgery (TLM) and radiotherapy (RT) are both accepted treatment modalities for glottic cancer. The objective of the study was to assess the oncologic outcomes and life quality of TLM in comparison with RT for T1 glottic carcinoma. We searched Medline/PubMed, Web of knowledge, EMBASE, the Cochrane Library, the Wiley online library, Springer, Google, China National Knowledge Infrastructure (CNKI), etc. We screened the literature, assessed the quality of the studies, and extracted the relevant data through the establishment of inclusion and exclusion criteria...
February 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/27902867/predictive-factors-and-treatment-outcome-of-laryngeal-carcinoma-recurrence
#14
Aaro Haapaniemi, Janne Väisänen, Timo Atula, Olli-Pekka Alho, Antti Mäkitie, Petri Koivunen
BACKGROUND: Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence. METHODS: A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy (n = 316) was analyzed. RESULTS: Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment...
November 30, 2016: Head & Neck
https://www.readbyqxmd.com/read/27863075/transoral-laser-microsurgery-versus-radiotherapy-for-t2-glottic-squamous-cell-carcinoma-a-systematic-review-of-local-control-outcomes
#15
L Warner, K Lee, J J Homer
BACKGROUND: Systematic reviews comparing treatment of early glottic cancer with transoral surgery or radiotherapy demonstrate similar oncological outcomes. Most studies of 'early-stage' laryngeal cancer include Tis, T1a, T1b and T2 cases. The data are dominated by patients with T1 and Tis tumours, although extrapolating these results and applying them for T2 cases may be inappropriate. No previous systematic reviews have focused on T2 cancers as a separate group. OBJECTIVE OF REVIEW: This review compares local control outcomes for T2 glottic squamous cell carcinoma, treated with transoral microsurgery or external beam radiotherapy...
November 10, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27846642/-stomal-cancer-recurrency-a-clinic-pathological-consideration
#16
S Teutsch, M Bas, H Bier, A Knopf
Objectives: Analysis of pre-operative tracheostomy and circumjacent tumour free margins as risk factors in the development of stomal recurrent disease after (pharyngo)laryngectomy. Material and Methods: 124 patients after (pharyngo)laryngectomy were analyzed for disease related data and tumour samples were analyzed for tumour free margins. The overall cohort was divided into patients with/withour pre-operative tracheostomy. Results: 18 patients suffered from recurrent disease (10 stomal, 8 distant metastases)...
November 15, 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27833963/anterior-commissure-laryngeal-neoplasm-endoscopic-management
#17
Nicolae Constantin Balica, Mărioara Poenaru, Eugen HoraŢiu Ştefănescu, Eugen Radu Boia, Caius Ion Doroş, Flavia Baderca, Octavian Mazilu
The CO2 laser surgery represents a treatment method of laryngeal bicordal and anterior commissure glottic cancer T1b, T2, N0. In Department of ENT, Timisoara, Romania, during 1.01.2001-31.12.2011 were analyzed 781 files from patients with laryngeal neoplasm. One hundred twenty-seven patients presented the tumor that involved both vocal cords and anterior commissure, stages T1b, T2 and T3. Therapeutic options included CO2 laser microsurgical excision for 55 (43.30%) patients, frontolateral hemilaryngectomy for 16 (12...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27812699/appropriate-treatment-of-t3-glottic-cancer
#18
Luca D'Ascanio, Marco Pappacena, Fabio Piazza
No abstract text is available yet for this article.
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27812697/appropriate-treatment-of-t3-glottic-cancer-reply
#19
Maha Al-Gilani, Bruce Haughey, Jay F Piccirillo
No abstract text is available yet for this article.
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27778345/evaluating-organ-preservation-outcome-as-treatment-endpoint-for-t1an0-glottic-cancer
#20
Tsu-Hui Hubert Low, David Yeh, Tina Zhang, Rakhna Araslanova, J Alex Hammond, David Palma, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, John Yoo, Anthony Nichols, Kevin Fung
OBJECTIVES/HYPOTHESIS: Common endpoints in reporting the outcomes for early glottic cancer do not highlight the importance of organ preservation. We evaluated the treatment outcomes among patients with T1aN0 laryngeal cancer with laryngectomy-free disease-specific survival (LFS-DSS), which is defined as time to total laryngectomy or time to death from cancer cause, against all other endpoints. STUDY DESIGN: Outcome research on an institutional database. METHODS: A retrospective review covered all consecutive patients from 2003 to 2013...
October 25, 2016: Laryngoscope
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