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glottic cancer

Z W Li, X X Li, J S Li, H Y Fang, G J Yang
No abstract text is available yet for this article.
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Jeroen Meulemans, Jacqueline Bijnens, Pierre Delaere, Vincent Vander Poorten
Introduction/aim: Transoral laser microsurgery (TLM) is a minimally invasive surgical alternative for radiotherapy (RT) in the primary management of early glottic cancer. More recently, TLM emerged also as a possible salvage treatment for selected radiorecurrent cancers. We reviewed outcomes of primary and salvage TLM performed in a Belgian tertiary referral center. Patients and methods: A retrospective review of records from 142 consecutive patients who underwent TLM was performed...
2018: Frontiers in Oncology
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
June 7, 2018: Scientific Reports
L Tao, L Zhou, H T Wu, X M Li, X L Chen, C Li, M Xie, M Zhang, L Cheng, D Tang
Objective: To explore the fundamental clinical characteristics and survival prognostic factors of laryngeal squamous cell carcinoma (LSCC) patients treated with open laryngeal function-preserving operations. Method: The collected clinical data and the follow-up survival information from 760 patients with LSCC undergoing open laryngeal function-preserving operations between January 2005 and December 2010 in Eye & ENT Hospital of Fudan University were retrospectively analyzed. Kaplan-Meier was applied to calculate survival rates...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Cesare Piazza, Marta Filauro, Alberto Paderno, Filippo Marchi, Pietro Perotti, Riccardo Morello, Stefano Taboni, Giampiero Parrinello, Fabiola Incandela, Andrea Iandelli, Francesco Missale, Giorgio Peretti
Introduction: The Union for International Cancer Control-American Joint Committee on Cancer TNM staging system for glottic squamous cell carcinoma (SCC) includes different types of lesions defined by the involvement of specific subsites in each T category. Our study aims to identify different subcategories according to tumor local extension and determine oncologic outcomes after treatment by transoral laser microsurgery (TLM) alone. Methods: We retrospectively evaluated 410 patients affected by previously untreated pT1-pT3 glottic SCC treated by TLM alone from January 2005 to December 2015 at the Departments of Otorhinolaryngology-Head and Neck Surgery, Universities of Genoa and Brescia, Italy...
2018: Frontiers in Oncology
Ana Gabriela Jover-Esplá, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, Joaquín de Juan-Herrero, Vicente Francisco Gil-Guillén
Only one prognostic model for laryngeal cancer has been published, but it has not been properly validated and is only applicable to patients treated with radiotherapy. Consequently, we constructed, internally validated and implemented in an App (Android), a predictive model of 5-year mortality in patients with glottic cancer in a cohort study of 189 patients with glottic cancer in 2004-2016 in Spain. The main variable was time-to-death. Secondary variables were age, gender, TNM, stage, smoking, alcohol consumption, histology and treatment...
June 5, 2018: European Journal of Cancer Care
J J Zhang, Q F Zhang, D L Liu
No abstract text is available yet for this article.
July 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Pietro Perotti, Marco Ferrari, Nausica Montalto, Davide Lancini, Alberto Paderno, Fabiola Incandela, Barbara Buffoli, Luigi Fabrizio Rodella, Cesare Piazza
Introduction: Carbon dioxide laser coagulation during transoral laser microsurgery (TLM) for laryngeal cancer allows control of bleeding from vessels smaller than 0.5 mm. Therefore, larger arteries and veins must be carefully managed by clipping and/or monopolar cautery. The aim of this paper is to detail endolaryngeal vascular anatomy and identify areas of possible bleeding during TLM. Methods: We performed an anatomical study on a series of 11 fresh-frozen human cadavers...
2018: Frontiers in Oncology
P Aluffi Valletti, F Taranto, A Chiesa, F Pia, G Valente
The management of positive resection margins in micro-endoscopic glottic laser surgery remains a controversial and critical point. This study aims to assess the impact of margin status after transoral laser surgery on local control, survival and organ preservation rates; the decision-making process and treatment options in cases with positive margins are also discussed. We retrospectively reviewed the clinical and histological records of 308 consecutive patients with primary early glottic carcinoma (T1a, T1b, selected T2) and treated with endoscopic laser cordectomy...
February 2018: Acta Otorhinolaryngologica Italica
Giovanni Succo, Erika Crosetti, Andy Bertolin, Cesare Piazza, Gabriele Molteni, Stefano Cirillo, Massimo Petracchini, Martina Tascone, Andrea Elio Sprio, Giovanni Nicolao Berta, Giorgio Peretti, Livio Presutti, Giuseppe Rizzotto
BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility)...
May 13, 2018: Head & Neck
Tosol Yu, Chan Woo Wee, Noorie Choi, Hong-Gyun Wu, Hyun-Cheol Kang, Jong Min Park, Jung-In Kim, Jin Ho Kim, Tack-Kyun Kwon, Eun-Jae Chung
OBJECTIVE: Avoidance of organs at risk has become possible with advances in image-guided volumetric-modulated arc therapy (VMAT) techniques. This study was designed to evaluate the safety and feasibility of stereotactic ablative radiotherapy (SABR) for early stage glottic cancer. This report presents the preliminary result of the first and second dose level. METHODS: Fraction size was increased from 3.5 gray (Gy) (total dose 59.5 Gy) to 9 Gy (total dose 45 Gy). Dose-limiting toxicities were defined as grade 3 or higher treatment-related toxicities...
May 14, 2018: Laryngoscope
Anna Rzepakowska, Ewelina Sielska-Badurek, Michal Żurek, Ewa Osuch-Wójcikiewicz, Kazimierz Niemczyk
BACKGROUND: This study investigates relevance of narrow band imaging (NBI) in stratifying risk of malignant transformation within leukoplakia. METHODS: We conducted a prospective analysis that included 62 patients with 91 changes of leukoplakia on vocal folds. The NBI was obtained before microsurgery. Categorization of the lesion as benign was made when vessels of surrounding epithelium were classified as type I, II, or IV according to Ni classification. If there were visualized intraepithelial papillary capillary loops of type V, the lesion was classified as malignant...
May 13, 2018: Head & Neck
Kathy Rock, Shao Hui Huang, Albert Tiong, Lin Lu, Wei Xu, Jolie Ringash, Scott V Bratman, Li Tong, Biu Chan, John Cho, Meredith Giuliani, Andrew Hope, Andrew Bayley, John Kim, John R de Almeida, Brian O'Sullivan, John Waldron
PURPOSE: To assess the impact of the radiation therapy (RT) regimen and image guidance (image guided radiation therapy [IGRT]) protocol on local control (LC) for T2N0 glottic cancer treated with partial laryngeal intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: All patients with T2N0 glottic cancer treated with IMRT from 2006 to 2013 at a single institution were retrospectively reviewed. The gross tumor volume (GTV), delineated from endoscopic and/or radiologic findings, was expanded 0...
March 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Ana Gabriela Jover-Esplá, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, Guillermo Severá-Ferrándiz, Manuela Sancho-Mestre, Joaquín de Juan-Herrero, Vicente Francisco Gil-Guillén
OBJECTIVES: The existing predictive models of laryngeal cancer recurrence present limitations for clinical practice. Therefore, we constructed, internally validated and implemented in a mobile application (Android) a new model based on a points system taking into account the internationally recommended statistical methodology. MATERIALS AND METHODS: This longitudinal prospective study included 189 patients with glottic cancer in 2004-2016 in a Spanish region. The main variable was time-to-recurrence, and its potential predictors were: age, gender, TNM classification, stage, smoking, alcohol consumption, and histology...
May 2018: Oral Oncology
Jianghong Xiao, Yan Li, Huashan Shi, Tangel Chang, Yong Luo, Xuetao Wang, Yang He, Nianyong Chen
OBJECTIVES: To evaluate the benefit of intensity-modulated radiation therapy (IMRT) with multi-criteria optimization (MCO) in patients with oropharyngeal cancer (OPC) and compare the dose difference between the MCO plans navigated by physicians and dosimetrists. MATERIALS AND METHODS: The conventional IMRT plans (nonMCO) and MCO IMRT plans navigated by physicians and dosimetrists (MCOp and MCOd) were created for 30patients with OPC. All the plans were reviewed, and the planning time and dose-volume parameters were compared...
May 2018: Oral Oncology
Jian Zhou, Liang Zhou, Lei Tao, Ming Zhang, Haitao Wu, Xiaoling Chen, Xiaoming Li, Cai Li, Hongli Gong
BACKGROUND: The purpose of this study was to assess the clinical results of patients with T3 glottic laryngeal carcinoma treated with total laryngectomy or partial laryngectomy. METHODS: We conducted a retrospectively review of 307 patients with T3 glottic laryngeal squamous cell carcinoma (SCC). RESULTS: The 5-year cancer-specific survival (CSS) rate was 71.5% and the overall survival (OS) rate was 70.6%. For patients who underwent total laryngectomy, the 5-year disease-free survival (DFS) rate was 59...
March 30, 2018: Head & Neck
Peter T Dziegielewski, William J Reschly, Chris G Morris, Reordan Danny DeJesus, Natalie Silver, Brian J Boyce, Inocente Santiago, Robert J Amdur, William M Mendenhall
BACKGROUND: The optimal treatment for T3 glottic cancers continues to be debated. Organ preservation has become the standard of care, but not all tumors respond equally. The purpose of this was to investigate the long-term survival outcomes of organ preservation protocols based on tumor volume. METHODS: A retrospective review of prospectively collected data from 1966 to 2016 was performed. Patients with T3 vocal cord cancer treated with radiation therapy (RT) at the University of Florida were included...
April 2018: Oral Oncology
Hanna Klimza, Joanna Jackowska, Cesare Piazza, Jacek Banaszewski, Malgorzata Wierzbicka
INTRODUCTION: Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. OBJECTIVE: The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the larynx mucosa in terms of specifying surgical margins. METHODS: Forty-four consecutive T1-T2 glottic cancers treated with trans-oral laser microsurgery Type I-VI cordectomy were presented...
March 1, 2018: Brazilian Journal of Otorhinolaryngology
Olga Jurek-Matusiak, Piotr Wójtowicz, Tomasz Szafarowski, Antoni Krzeski
PURPOSE OF THE STUDY: The aim of the study was to present the treatment outcomes after vertical partial laryngectomy with or without pedunculated sternothyroid muscle flap reconstruction following the resection of neoplasm-infiltrated vocal fold. The procedure was used in a patient with glottic cancer. Oncological outcomes, morphology of neo-vocal fold and the act of swallowing were evaluated. MATERIAL AND METHODS: 45 patients with T1-T2 glottic cancer were subjected to vertical partial laryngectomy with 26 patients undergoing a procedure with pedunculated sternothyroid muscle flap reconstruction and the remaining 19 patients undergoing a procedure without such a reconstruction...
February 28, 2018: Otolaryngologia Polska
Shuo Ding, Junwei Huang, Zhigang Huang, Hongbo Xu, Wei Guo, Yang Zhang
BACKGROUND: The lack of standardized treatment is problematic in laser surgery for laryngeal cancer, and may result in an increased recurrence rate. This study analyzed the prognosis of early laryngeal carcinoma after different types of cordectomy with laser surgery. METHODS: A cohort of 818 patients with stage Tis or T1 primary early glottic squamous cell carcinoma treated with CO2 laser surgery was retrospectively analyzed. RESULTS: Of the 818 patients, According to the Kaplan-Meier method, the rate of 5-year overall survival was 92...
March 5, 2018: Acta Oto-laryngologica
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