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https://www.readbyqxmd.com/read/28631160/role-of-imaging-in-the-follow-up-of-t2-t3-glottic-cancer-treated-by-transoral-laser-microsurgery
#1
Filippo Marchi, Cesare Piazza, Marco Ravanelli, Giovanna Gaggero, Giampiero Parrinello, Alberto Paderno, Pietro Perotti, Marta Filauro, Roberto Maroldi, Giorgio Peretti
An unblinded retrospective analysis of prospectively collected data was carried out on 138 patients affected by glottic pT2 and selected pT3 squamous cell carcinomas (SCC) treated by transoral laser microsurgery (TLM). The entire cohort was divided into two groups: Group A included 78 "high-risk" patients (pT2 with impaired vocal cord mobility, pT3 for anterior paraglottic and/or pre-epiglottic space invasion, presence of angioembolization, perineural spread, and positive lymph nodes in the neck) who underwent postoperative surveillance by endoscopy and imaging (CT or MR), while Group B included 60 "low-risk" patients (pT2 with absence of the above-mentioned features) who underwent endoscopic follow-up alone...
June 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28583473/predictors-of-local-recurrence-of-glottic-cancer-in-patients-after-transoral-laser-microsurgery
#2
Chia-Fan Chang, Pen-Yuan Chu
BACKGROUND: Transoral laser microsurgery (TLM) is used to treat early and select cases of moderately advanced glottic cancer, with results equivalent to those of conventional conservative surgery and radiotherapy (RT). As surgeons and researchers become more experienced and familiar with TLM, they can focus on mechanisms to earlier detect local recurrence, to more effectively preserve laryngeal function. This study analyzed the predictors of local recurrence in glottic cancer patients who underwent TLM...
June 2, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28571040/videolaryngoscopy-during-conscious-sedation-in-patients-not-suitable-for-phonosurgery-by-microlaryngoscopy-a-pilot-study
#3
Vincenzo Saita, Eugenia Allegra, Nicolò Marino, Serena Trapasso, Maria Concetta Monea
BACKGROUND: Microlaryngoscopy is the preferred and most widely used technique in phonosurgery for the treatment of benign and early malignant glottic lesions. However, the procedure may be technically difficult or impossible due to alterations of the cervical spine that may not allow hyperextension of the head or may present general anesthesia contraindications. The aim of this study is to evaluate the efficacy and safety of our surgical approach for lesions of the vocal folds in patients who are not suitable for phonosurgery by microlaryngoscopy...
June 2, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28561907/clinical-significance-of-epithelial-to-mesenchymal-transition-in-laryngeal-carcinoma-its-role-in-the-different-subsites
#4
Silvia Mezi, Caterina Chiappetta, Raffaella Carletti, Andrea Nardini, Enrico Cortesi, Errico Orsi, Gabriele Piesco, Cira Di Gioia
BACKGROUND: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. METHODS: E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. RESULTS: Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse...
May 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28558457/-diagnostic-value-of-enhanced-ct-mri-for-thyroid-cartilage-invasion-by-malignant-tumor
#5
H Y Li, X H Chen
Objective: To evaluate the values of enhanced CT and MRI for the diagnosis of thyroid cartilage invasion by laryngeal and hypopharyngeal cancer. Methods: One hundred and ninety-seven patients with primary laryngeal or hypopharyngeal cancer treated with surgery between January 2013 and December 2014 were included in this study. All patients underwent enhanced CT and MRI before surgery. With MRI using the techniques of fast recovery fast spin echo (FRFSE), spin echo echo planar imaging (SE-EPI) and diffusion weighted imaging (DWI), thyroid cartilage invasion was evaluated and the results of postoperative histopathological examination was used as a gold standard for the determination of thyroid cartilage invasion...
May 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28558451/-treatment-of-glottic-cancer-involving-the-anterior-commissure-by-transoral-co-2-laser-surgery
#6
J J Li, J L Zhang, F Y He, S C Tang, Z F Zhu, W X Chen
Objective: To study the clinical outcome of transoral CO(2) laser surgery for glottic cancer involving the anterior commissure. Methods: Thirty-two cases of glottic cancer involving the anterior commissure treated by transoral CO(2) laser surgery between March 2009 and December 2013 were retrospectively reviewed. Among these cases, 27 were T1bM0M0, 5 were T2N0M0. All cases were followed-up for more than 3 years. Results: All the 32 cases were successfully treated. Perioperative complications included injuries in the soft palate mucosa(13/32, 40...
May 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28557310/larynx-motion-considerations-in-partial-larynx-volumetric-modulated-arc-therapy-for-early-glottic-cancer
#7
Houda Bahig, Phuc Félix Nguyen-Tan, Édith Filion, David Roberge, Pensavan Thanomsack, Jacques de Guise, Danis Blais, Robert Doucet, Laurent Létourneau-Guillon, Louise Lambert
INTRODUCTION: To assess laryngeal motion in early glottic cancer in order to determine safe margins for partial larynx volumetric modulated arc therapy (PL-VMAT), and to quantify dosimetric advantages of PL-VMAT. METHODS: This prospective study included T1-2N0 glottic cancers treated with whole larynx VMAT (WL-VMAT). Pre- and mid-treatment 4D-computed tomography (4D-CT) and dynamic magnetic resonance imaging (MRI) allowed for assessment of larynx swallowing and respiratory motion...
May 30, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28534319/case-report-human-papilloma-virus-type-120-related-papillomatosis-mimicking-laryngeal-carcinoma
#8
Valeria Belvisi, Salvatore Martellucci, Anna Rosa Garbuglia, Cosmo Del Borgo, Stanislao Martellucci, Andrea Baiocchini, Anna Maria Manicone, Oreste Bagni, Claudio Maria Mastroianni, Andrea Gallo
INTRODUCTION: The relationship between human papilloma virus (HPV) and upper respiratory tract pathology was better understood in recent years and represents now an issue of particular interest in carcinogenesis and in immunocompromised host. We describe a case in which a rare genotype HPV-related papillomatosis mimics laryngeal carcinoma in an immunocompromised host. METHODS: A 54-year-old woman with a history of HIV-HCV coinfection and anal and laryngeal cancer successfully treated some years before was hospitalized for severe dyspnea, cough and dysphagia...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28530251/impact-of-resection-margin-status-on-oncological-outcomes-after-co2-laser-cordectomy
#9
P Aluffi Valletti, F Taranto, A Chiesa, F Pia, G Valente
The management of positive resection margins in micro-endoscopic glottic laser surgery remains a controversial and critical point. This study aims to assess the impact of margin status after transoral laser surgery on local control, survival and organ preservation rates; the decision- making process and treatment options in cases with positive margins are also discussed. We retrospectively reviewed the clinical and histological records of 308 consecutive patients with primary early glottic carcinoma (T1a, T1b, selected T2) and treated with endoscopic laser cordectomy...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28522278/a-large-french-multicenter-retrospective-series-of-t1-t2n0-vocal-cords-carcinomas-treated-with-exclusive-irradiation
#10
A Robert, Y Pointreau, G Janoray, É Bardet, M Fesneau, P Garaud, S Chapet, C Lafond, O Dupuis, G Calais
PURPOSE: The main objective of this study was to evaluate the 5-year efficacy of exclusive laryngeal radiotherapy without node prophylactic irradiation for localized cancers of the vocal cords. PATIENTS AND METHODS: We retrospectively reviewed charts from 258 patients with T1-T2N0 glottic carcinoma irradiated from April 1987 to March 2015 in four France western centers, including pretreated patients. Toxicity was analyzed according to CTCAE v4.0 classification. RESULTS: The median follow-up was 50 months...
May 15, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28521361/hypofractionated-radiotherapy-for-patients-with-early-stage-glottic-cancer-patterns-of-care-and-survival
#11
Trevor J Bledsoe, Henry S Park, John M Stahl, Wendell G Yarbrough, Barbara A Burtness, Roy H Decker, Zain A Husain
Background: Radiotherapy alone is often used to treat early-stage glottic cancer (ESGC); however, the optimal radiation treatment schedule remains unknown. The National Comprehensive Cancer Network (NCCN) guidelines recommend both hypofractionated radiotherapy (HFX) and conventionally fractionated radiotherapy (CFX). We compared overall survival (OS) and treatment patterns among patients treated with HFX vs CFX for ESGC using a large national database. Methods: We identified patients diagnosed with stage I-II (cT1-2N0M0) glottic cancer from 2004 to 2013 within the National Cancer Data Base who were treated with either HFX (2...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28516961/supracricoid-partial-laryngectomy-with-crico-hyoido-epiglottopexy-for-glottic-carcinoma-with-anterior-commissure-involvement
#12
I Atallah, E Berta, A Coffre, J Villa, E Reyt, C A Righini
Glottic cancers discovered at an early stage (T1-T2) can be treated with either radiotherapy or surgery. The aim of our study is to analyse survival and functional results of supra-cricoid partial laryngectomy (SCPL) with crico-hyoido-epiglottopexy (CHEP) as surgical treatment for glottic carcinoma with anterior commissure involvement. We performed a retrospective study (1996-2013) which included patients who underwent SCPL-CHEP for glottic squamous cell carcinoma with involvement of the anterior commissure...
June 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28496338/the-voice-quality-after-laser-surgery-versus-radiotherapy-of-t1a-glottic-carcinoma-systematic-review-and-meta-analysis
#13
Guanjiang Huang, Mengsi Luo, Jingxuan Zhang, Hongbing Liu
BACKGROUND AND OBJECTIVES: The voice quality assessment of laser surgery (LS) in comparison with radiotherapy (RT) remains uncertain in T1a glottic carcinoma treatment. This systematic review and meta-analysis were conducted to compare the voice quality of the two treatments. METHODS: Searches were conducted in PubMed, EMBASE, and Cochrane with the following index words: glotti*, layn*, vocal cord, vocal, surgery, cordectomy, laser, radiation, irradiation, radiotherapy, cancer, and carcinoma for relative studies that compared the voice quality between LS and RT...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28495481/prediction-of-local-control-in-early-glottic-carcinoma-using-the-maximum-standardised-uptake-value
#14
J W Park, S W Lee, J S Kim, S Y Song
PURPOSE: This retrospective study aimed to determine whether the maximum standardised uptake value (SUVmax) can predict local tumour control in early glottic cancer (Tis, T1, and T2). PATIENTS AND METHODS: Fifty-nine patients treated with definitive radiotherapy for early glottic cancer between 2003 and 2011 were enrolled. We evaluated the SUVmax in the region of interest around the original tumour site. Local tumour control and survival were estimated using Kaplan-Meier curves...
May 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28474090/t1-2-glottic-cancer-treated-with-radiotherapy-and-or-surgery
#15
Mohamed Shelan, Lukas Anschuetz, Adrian D Schubert, Beat Bojaxhiu, Alan Dal Pra, Frank Behrensmeier, Daniel M Aebersold, Roland Giger, Olgun Elicin
BACKGROUND: The optimal treatment strategy for stage I-II glottic squamous cell carcinoma (SCC) is not well-defined. This study analyzed treatment results and prognostic factors. PATIENTS AND METHODS: This is a single-institution retrospective analysis of 244 patients with T1-2 glottic SCC who underwent normofractionated radiotherapy (RT) and/or surgery between 1990 and 2013. The primary endpoint was relapse-free survival (RFS). RESULTS: Median age was 65 years (range: 36-92 years), the majority (82%) having stage I disease...
May 4, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28438431/phantom-to-clinic-development-of-hypofractionated-stereotactic-body-radiotherapy-for-early-stage-glottic-laryngeal-cancer
#16
Chuxiong Ding, Stephen G Chun, Baran D Sumer, Lucien A Nedzi, Ramzi E Abdulrahman, John S Yordy, Pam Lee, Brian Hrycushko, Timothy D Solberg, Chul Ahn, Robert D Timmerman, David L Schwartz
The purpose of this study was to commission and clinically test a robotic stereotactic delivery system (CyberKnife, Sunnyvale, CA) to treat early-stage glottic laryngeal cancer. We enrolled 15 patients with cTis-T2N0M0 carcinoma of the glottic larynx onto an institutional review board (IRB)-approved clinical trial. Stereotactic body radiotherapy (SBRT) plans prescribed 45 Gy/10 fractions to the involved hemilarynx. SBRT dosimetry was compared with (1) standard carotid-sparing laryngeal intensity-modulated radiation therapy (IMRT) and (2) selective hemilaryngeal IMRT...
July 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28370672/narrow-band-imaging-in-transoral-laser-surgery-for-early-glottic-cancer-in-relation-to-clinical-outcome
#17
Boudewijn E C Plaat, Manon A Zwakenberg, Joost G van Zwol, Jan Wedman, Bernard F A M van der Laan, György B Halmos, Frederik G Dikkers
BACKGROUND: The purpose of this study was to validate the prognostic value of adding narrow-band imaging (NBI) during transoral laser surgery (TLS) for early glottic cancer. METHODS: In 84 patients, 93 transoral laser resections were performed for carcinoma in situ (Tcis), T1, or T2 glottic cancer. TLS was preceded by intraoperative evaluation using traditional white-light imaging (WLI) in 51 cases. In 42 cases, NBI was used in addition to WLI. Local recurrence rate and recurrence-free survival were retrospectively compared between both groups...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28301924/radiotherapy-versus-cordectomy-in-the-management-of-early-glottic-cancer
#18
Seung Yeun Chung, Kyung Hwan Kim, Ki Chang Keum, Yoon Woo Koh, Se-Heon Kim, Eun Chang Choi, Chang Geol Lee
Purpose: To compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods: A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), disease-free survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated...
March 17, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28291932/online-dosimetric-evaluation-of-larynx-sbrt-a-pilot-study-to-assess-the-necessity-of-adaptive-replanning
#19
Weihua Mao, Timothy Rozario, Weiguo Lu, Xuejun Gu, Yulong Yan, Xun Jia, Baran Sumer, David L Schwartz
PURPOSE: We have initiated a multi-institutional phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for Stage III-IVa laryngeal cancer. We conducted this pilot dosimetric study to confirm potential utility of online adaptive replanning to preserve treatment quality. METHODS: We evaluated ten cases: five patients enrolled onto the current trial and five patients enrolled onto a separate phase I SBRT trial for early-stage glottic larynx cancer. Baseline SBRT treatment plans were generated per protocol...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28277333/voice-outcomes-for-early-laryngeal-cancer
#20
Andrew J Kinshuck, Aditya Shenoy, Terry M Jones
PURPOSE OF REVIEW: Treatment options for early laryngeal cancer are well established with good local control and 5-year survival. The commonest treatments are radiotherapy or transoral laser microsurgery (TLM). There are advantages and disadvantages of the different modalities, but debate continues regarding the voice outcomes posttreatment. This review will focus on early glottic carcinoma and voice outcomes following the different treatments. RECENT FINDINGS: TLM and radiotherapy are both likely to affect voice quality, but the extent of voice change depends on different factors...
June 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
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