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cervical pregnancy

Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Malayannan Subramaniam, John R Hawse, Kevin S Pitel, Hugo Arreola-De la Cruz, Victor Huerta-Padilla, Gustavo Ponce-Navarrete, Ma Del Pilar Figueroa-Corona, Laura Gomez-Virgilio, Teresa I Martinez-Cuevas, Monica Mendoza-Rodriguez, Miriam Rodriguez-Esquivel, Pablo Romero-Morelos, Jorge Ramirez-Salcedo, Michael Baudis, Marco Meraz-Rios, Florinda Jimenez-Vega, Mauricio Salcedo
Cervical cancer (CC) is associated with alterations in immune system balance, which is primarily due to a shift from Th1 to Th2 and the unbalance of Th17/Treg cells. Using in silico DNA copy number analysis, we have demonstrated that ~20% of CC samples exhibit gain of 8q22.3 and 19q13.31; the regions of the genome that encodes the KLF10 and PSG genes, respectively. Gene expression studies demonstrated that there were no alterations in KLF10 mRNA expression, whilst the PSG2 and -5 genes were up-regulated by 1...
June 21, 2018: Scientific Reports
Nicholas A Levine, Brandon R Rigby
Thoracic outlet syndrome (TOS) describes a group of disorders that are due to a dynamic compression of blood vessels or nerves, between the clavicle and first rib or cervical vertebral nerve roots. Individuals with TOS typically experience upper limb pain, numbness, tingling, or weakness that is exacerbated by shoulder or neck movement. The causes of TOS vary, and can include abrupt movements, hypertrophy of the neck musculature, and anatomical variations in which the brachial plexus roots pass through this musculature, edema, pregnancy, repeated overhead motions, the blockage of an artery or vein, or abnormal posture...
June 19, 2018: Healthcare (Basel, Switzerland)
Lesley Hoggart, Susan Walker, Victoria Louise Newton, Mike Parker
OBJECTIVES: Intrauterine contraception (IUC) is highly effective, safe and long-lasting, but is not a popular method of contraception among British women. This study examined barriers to the uptake of IUC in general practice in England. METHOD: A sequential mixed-method approach to explore the views of practitioners regarding the provision of IUC. We e-surveyed 208 practitioners from 69 practices in a region of England and subsequently interviewed 14 practitioners from eight practices...
April 2018: BMJ sexual & reproductive health
Angharad Care, Bertram Muller-Myhsok, Elena Olearo, Tullia Todros, Javier Caradeux, Maria Goya, Montse Palacio, Elena Carreras, Zarko Alfirevic
OBJECTIVE: The aim of this study was to investigate whether the classification of a previous spontaneous preterm birth (sPTB) into; i) sPTB or ii) PPROM, impacts the efficacy of cervical pessary or vaginal progesterone in pregnant women with short cervix on transvaginal ultrasound. METHODS: Four European hospitals using pessary or vaginal progesterone as a primary PTB prevention treatment for asymptomatic high-risk singletons with a short cervix, provided retrospective cohort data...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
Yu Zhao, Kaifeng Wu, Huabo Tong, Yan Liu, He Zha, Huan Yue, Jingzhi Zhang, Xiaoyun Liu
OBJECTIVES: To determine the patterns and prevalence of human papilloma virus (HPV) genotypes in people who are not vaccinated with HPV vaccines in Zunyi. METHODS: We retrospectively collected all HPV testing results in 3,393 patients at the Third Affiliated Hospital in Zunyi Medical University, Zunyi, China between January 2014 and December 2016. The prevalence of HPV genotypes based on different stages of cervical lesions and age groups was analyzed. The clinical data of 347 HPV-positive inpatients were also retrospectively collected, and difference in the age at first sexual encounter, smoking, pregnancy, and abortion status were compared...
June 2018: Saudi Medical Journal
Keiko Taniguchi-Ponciano, Daniel Marrero-Rodríguez, Hugo Arreola-De la Cruz, Víctor Huerta-Padilla, Nancy Muñoz, Laura Gómez-Ortiz, Gustavo Ponce-Navarrete, Miriam Rodríguez-Esquivel, Mónica Mendoza-Rodríguez, Laura Gómez-Virgilio, Raúl Peralta, Luis Serna, Guillermo Gómez, Jorge Ortiz, Alejandra Mantilla, Daniel Hernández, Ángeles Hernández, Cindy Bandala, Rosa María Ribas-Aparicio, Mauricio Salcedo
BACKGROUND: Similarities between the pathologic progression of cancer and the physiologic process of placentation have been recognized for many years proposing that both present similar mechanisms and processes. Cervical cancer (CC) is one of the most frequent neoplasia among Mexican women turning it into an important health problem. OBJECTIVE: The aim of this study was to determine the degree of the involvement of pregnancy related genes and in cancer progression by insilico analysis and validated in CC samples...
May 31, 2018: Cancer Biomarkers: Section A of Disease Markers
Richard A Anderson, David H Brewster, Rachael Wood, Sian Nowell, Colin Fischbacher, Tom W Kelsey, W Hamish B Wallace
STUDY QUESTION: What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy? SUMMARY ANSWER: Cancer survivors achieved fewer pregnancies across all cancer types, and the chance of achieving a first pregnancy was also lower. WHAT IS KNOWN ALREADY: The diagnosis and treatment of cancer in young females may be associated with reduced fertility but the true pregnancy deficit in a population is unknown. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study relating first incident cancer diagnosed between 1981 and 2012 to subsequent pregnancy in all female patients in Scotland aged 39 years or less at cancer diagnosis (n = 23 201)...
June 15, 2018: Human Reproduction
Emrah Dagdeviren, Berna Aslan Çetin, Begum Aydogan Mathyk, Nadiye Koroglu, Elif Goknur Topcu, Mehmet Aytac Yuksel
PURPOSE: Induction of labor is a common practice in obstetrics. In recent years, a newer ultrasonographic parameter called the uterocervical angle (UCA) has been identified as a predictive tool for births. Our purpose is to investigate the role of UCA in predicting successful induction of labor. METHODS: The nulliparous term pregnancies (n:150) were grouped into successful/failed inductions of labor based on their progress into the active phase of labor after the administration of prostaglandin E2 (dinoprostone)...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jing Guo, Ying Zhang, Xiaofei Chen, Lin Sun, Kai Chen, Xiugui Sheng
STUDY OBJECTIVE: To compare the surgical and oncologic outcomes between radical abdominal trachelectomy and radical hysterectomy (RH) for stage IA2-IB1 cervical cancer. DESIGN: Ⅱ-2: : Retrospective cohort study. SETTING: Shandong Cancer Hospital. PATIENTS: 329 patients with IA2-IB1 cervical cancer. INTERVENTIONS: All patients underwent radical abdominal trachelectomy (ART) or RH. MEASUREMENTS AND MAIN RESULTS: All patients were divided into ART (n=143) and RH (n=186) group according to surgical approach...
June 13, 2018: Journal of Minimally Invasive Gynecology
Colette Nickodem, Michael F Criscitiello, Fuller Bazer, Olayinka Abiodun-Ojo, Brandie D Taylor
PROBLEM: Recently characterized interferon epsilon (IFNe) protects against sexually transmitted infections, including genital herpes simplex virus (HSV), in animal models. There are no reports of IFNe in genital tract secretions of pregnant women, and data on IFNe in non-pregnant women are limited. This pilot study is the first to measure concentrations of IFNe in vaginal and cervical secretions during pregnancy and compare values between healthy and genital HSV-infected women. METHOD OF STUDY: Vaginal or cervical specimens from 30 pregnant women were obtained from the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) repository...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
V Pez, P Deruelle, M Kyheng, C Boyon, E Clouqueur, C Garabedian
OBJECTIVE: To compare the effectiveness of single balloon catheter with double balloon catheter and dinoprostone insert for cervical ripening and labor induction on unfavourable cervix. METHODS: this is a comparative, retrospective, one-center trial. Were included singleton pregnancy in cephalic presentation. Were excluded cicatricial uterus. The outcomes were vaginal delivery rate, caesarean section rate, modification in Bishop score, time from induction to delivery, second time prostaglandin E2 resort, oxytocin administration resort, maternal or neonatal adverse events...
June 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
A J M van de Sande, M M Koeneman, C G Gerestein, A J Kruse, F J van Kemenade, H J van Beekhuizen
BACKGROUND: Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical. This procedure has potential complications, such as haemorrhage, infection and preterm birth in subsequent pregnancies. Moreover, 15% of women treated for high grade CIN develop residual/recurrent CIN or cervical cancer after surgical excision. Finally, 75-100% of patients with a residual and recurrent CIN 2-3 lesion are still HPV positive...
June 15, 2018: BMC Cancer
Lakshmy Ravi Selvaraj, Nity Rose, Meenakshi Ramachandran
Cesarean scar pregnancy (CSP) is a rare kind of ectopic pregnancy implanted in the previous cesarean scar and has an increasing incidence over the past 30 years. As the suspicion is low, the diagnosis may be delayed or misinterpreted in ultrasound, leading to treatment strategies that might end up in uterine rupture or hysterectomy. The objective here is to review the ultrasound findings in CSP with varied presentations. Transabdominal and transvaginal sonography combined with color Doppler is a reliable tool for the diagnosis of CSP...
June 2018: Journal of Obstetrics and Gynaecology of India
Mathilde Vital, Joséphine Grange, Aurélie Le Thuaut, Jérôme Dimet, Guillaume Ducarme
OBJECTIVE: To identify predictors of successful cervical ripening using double-balloon catheter (DBC) for labor induction among women with previous cesarean delivery (PCD) and unfavorable cervix at term. METHODS: The present prospective observational study was conducted among women who underwent cervical ripening with DBC at a French tertiary care hospital between January 1, 2014, and December 31, 2017. Inclusion criteria were PCD; singleton term fetus; cephalic presentation; and unfavorable cervix (Bishop score <6)...
June 12, 2018: International Journal of Gynaecology and Obstetrics
Agustin L Lujan, Diego O Croci, Julián A Gambarte Tudela, Antonella D Losinno, Alejandro J Cagnoni, Karina V Mariño, María T Damiani, Gabriel A Rabinovich
Chlamydia trachomatis ( Ct ) constitutes the most prevalent sexually transmitted bacterium worldwide. Chlamydial infections can lead to severe clinical sequelae including pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. As an obligate intracellular pathogen, Ct has evolved multiple strategies to promote adhesion and invasion of host cells, including those involving both bacterial and host glycans. Here, we show that galectin-1 (Gal1), an endogenous lectin widely expressed in female and male genital tracts, promotes Ct infection...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
Hongmei Zhuang, Shurong Hong, Lin Zheng, Layue Zhang, Xueyi Zhuang, Hua Wei, Yuqing Yang
To assess the effect of cervical conisation on pregnancy outcome, a literature search strategy was conducted to identify all of the references lists of the relevant studies. The fixed or random effect model was used to calculate pooled RRs on the basis of heterogeneity. Twenty-seven publications with n cases and m controls were included in the meta-analysis. The results showed that conisation was associated with a higher risk of a preterm delivery (p = .010), PROM (p = .008), and a lower birth weight (p < ...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Faruk O Basegmez, Kevin Coetzee
In this study, the endometrial developmental and reproductive outcomes of frozen embryo transfers (FETs) which were performed subsequent to miscarriages managed by dilation and curettage (D and C) were investigated. The intracytoplasmic sperm injection (ICSI) blastocyst freeze-all cycles performed between January 2014 and August 2016 were screened for the patients who had undergone their FET (first), miscarriages (>5 < 14 weeks), D and C, and the patients who had undergone their FET (second) (study group; n = 71); and patients who underwent FET (1st), a chemical pregnancy loss (PL) (<5 weeks) and FET (2nd) (reference group; n = 38)...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Kausar Jabeen, Jagadeeswari Karuppaswamy
The aim of this paper is to review the diagnosis and treatment of patients with a caesarean scar pregnancy (CSP), who have been managed at our unit, as well as to evaluate the effectiveness of the non-surgical treatment options. Twenty-six cases were identified over a period of 5 years and 4 months (January 2012 until April 2017). The main outcome measures were a number of previous caesarean births, a method of diagnosis of CSP, the mode of treatment and the outcome. The diagnostic criteria on the ultrasound were an empty uterine cavity and cervical canal, the presence of a gestational sac anterior to the isthmic portion of the uterus, an absent or thinned (<5 mm) myometrial thickness between the gestational sac and the bladder, with a peri-trophoblastic circulation around the gestational sac with the colour flow Doppler examination...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Hytham Atia, Mohamed Ellaithy, Ahmed Altraigey, Mohamed Kolkailah, Amal Alserehi, Shabana Ashfaq
OBJECTIVE: During delivery counseling, some women with previous uncomplicated cesarean section (CS) wish mechanical induction of labor (IOL) but they are not accepting the added risk of using ecbolics to induce and/or augment labor. The objective of the study was to assess the safety and efficacy of the isolated use of transcervical Foley's catheter balloon as a mean of mechanical cervical ripening (CR)/IOL and successful ecbolic-less vaginal birth after cesarean section (VBAC). MATERIALS AND METHODS: A cohort study was conducted in two tertiary care maternity hospitals between October 2013 and July 2016 and recruited women with singleton pregnancy and cephalic presentation who had previous one uncomplicated CS and were scheduled for mechanical CR/IOL at term for routine obstetric indications...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
Soo Ran Choi, Soon-Sun Hong, Juyoung Kim, Keun-Young Lee
OBJECTIVE: The aim of the study was to determine the relationships between short cervical length (CL) and levels of cervical fluid neutrophil elastase (NE), secretory leukocyte protease inhibitor (SLPI), and interleukin 8 (IL-8) in the second trimester of pregnancy of women who underwent ultrasound-indicated cervical cerclage. MATERIALS AND METHODS: CL of <25 mm or cervical funneling were included in the short CL group (n = 26) and the normal CL group (n = 22) included women who had CL of ≥25 mm and had no cervical funneling in women between 17 + 0 and 24 + 6 weeks of gestation...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
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