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Subcutaneous ketamine

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https://www.readbyqxmd.com/read/27847695/combined-ketamine-tramadol-subcutaneous-wound-infiltration-for-multimodal-postoperative-analgesia-a-double-blinded-randomized-controlled-trial-after-renal-surgery
#1
Mohammad Reza Khajavi, Marzieh Navardi, Reza Shariat Moharari, Pejman Pourfakhr, Narjes Khalili, Farhad Etezadi, Farsad Imani
BACKGROUND: Pain is an important consideration after renal surgery. A multimodal approach to postoperative pain management could enhance analgesia by risking fewer side effects after surgery. OBJECTIVES: The aim of this study was to evaluate the clinical efficacy of the subcutaneous infiltration of ketamine and tramadol at the incision site to reduce postoperative pain. METHODS: Sixty-four patients between 18 and 80 years old who were scheduled for elective renal surgery were enrolled in a double-blind randomized controlled study...
October 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27474362/identification-of-drugs-in-parenteral-pharmaceutical-preparations-from-a-quality-assurance-and-a-diversion-program-by-direct-analysis-in-real-time-accutoftm-mass-spectrometry-dart-ms
#2
Justin L Poklis, Amanda J Mohs, Carl E Wolf, Alphonse Poklis, Michelle R Peace
In healthcare settings drug diversion and impairment of physicians are major concerns requiring a rapid and efficient method for surveillance and detection. A Direct Analysis in Real Time ion source coupled to a JEOL AccuTOF(TM) time-of-flight mass spectrometer (DART-MS) method was developed to screen parenteral pharmaceutical formulations for potential drug diversion. Parenteral pharmaceutical formulations are also known as injectable formulations and are used with intravenous, subcutaneous, intramuscular and intra-articular administration...
October 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27261525/the-n-methyl-d-aspartate-glutamate-receptor-antagonist-ketamine-disrupts-the-functional-state-of-the-corticothalamic-pathway
#3
Paul M Anderson, Nigel C Jones, Terence J O'Brien, Didier Pinault
The non-competitive N-methyl d-aspartate glutamate receptor (NMDAR) antagonist ketamine elicits a brain state resembling high-risk states for developing psychosis and early stages of schizophrenia characterized by sensory and cognitive deficits and aberrant ongoing gamma (30-80 Hz) oscillations in cortical and subcortical structures, including the thalamus. The underlying mechanisms are unknown. The goal of the present study was to determine whether a ketamine-induced psychotic-relevant state disturbs the functional state of the corticothalamic (CT) pathway...
June 3, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27177565/comparison-of-dexmedetomidine-ketamine-with-isoflurane-for-anesthesia-of-chinchillas-chinchilla-lanigera
#4
Lana Fox, Lindsey Bc Snyder, Christoph Mans
The objective of this study was to compare isoflurane with a combination of dexmedetomidine and ketamine, administered intramuscularly, for anesthesia in chinchillas (Chinchilla lanigera). In a prospective, complete crossover study, adult chinchillas (n = 8; age, 2 to 5 y) were anesthetized with a combination of dexmedetomidine (0.015 mg/kg IM) and ketamine (4 mg/kg IM). Atipamezole (0.15 mg/kg) was injected subcutaneously 45 min after dexmedetomidine-ketamine administration. For comparison, anesthesia also was induced and maintained with isoflurane in 100% oxygen, delivered by facemask...
2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27155360/detailed-pharmacological-evaluation-of-methoxetamine-mxe-a-novel-psychoactive-ketamine-analogue-behavioural-pharmacokinetic-and-metabolic-studies-in-the-wistar-rat
#5
Rachel R Horsley, Eva Lhotkova, Katerina Hajkova, Bronislav Jurasek, Martin Kuchar, Tomas Palenicek
Methoxetamine (MXE) is a novel psychoactive compound (NPS) that emerged in 2010 as a substitute for the dissociative anaesthetic ketamine. MXE has a reputation of carrying a lower risk of harm than ketamine, however a number of deaths have been reported. Currently very little is known about the psychopharmacological effects of this compound or its toxicity; therefore we tested, in Wistar rats, the effects of MXE in a series of behavioural tasks, measured its pharmacokinetics and urinary metabolites. Locomotor activity and its spatial characteristics (in the open field) and sensorimotor gating (prepulse inhibition; PPI) were evaluated after 5, 10 and 40mg/kg subcutaneous (sc...
May 4, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27092576/subanesthetic-subcutaneous-ketamine-infusion-therapy-in-the-treatment-of-chronic-nonmalignant-pain
#6
Olfat Zekry, Stephen B Gibson, Arun Aggarwal
This study was designed to describe the efficacy and toxicity of subcutaneous ketamine infusions and sublingual ketamine lozenges for the treatment of chronic nonmalignant pain. Data were collected prospectively on 70 subjects managed in an academic, tertiary care hospital between 2007 and 2012 who received between 3 and 7 days of subanesthetic, subcutaneous ketamine infusion. Data were analyzed for efficacy, adverse effects, and reduction in use of opioid medication. We also analyzed whether subsequent treatment with sublingual ketamine lozenges resulted in longer-term efficacy of the beneficial effects of the initial ketamine infusion...
June 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27028832/placebo-controlled-pilot-trial-testing-dose-titration-and-intravenous-intramuscular-and-subcutaneous-routes-for-ketamine-in-depression
#7
C K Loo, V Gálvez, E O'Keefe, P B Mitchell, D Hadzi-Pavlovic, J Leyden, S Harper, A A Somogyi, R Lai, C S Weickert, P Glue
OBJECTIVE: This pilot study assessed the feasibility, efficacy and safety of an individual dose-titration approach, and of the intravenous (IV), intramuscular (IM) and subcutaneous (SC) routes for treating depression with ketamine. METHOD: Fifteen treatment-refractory depressed participants received ketamine or midazolam (control treatment) in a multiple crossover, double-blind study. Ketamine was administered by IV (n = 4), IM (n = 5) or SC (n = 6) injection. Dose titration commenced at 0...
July 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/26834167/oral-ketamine-for-the-treatment-of-pain-and-treatment-resistant-depression%C3%A2
#8
REVIEW
Robert A Schoevers, Tharcila V Chaves, Sonya M Balukova, Marije Aan Het Rot, Rudie Kortekaas
BACKGROUND: Recent studies with intravenous (i.v.) application of ketamine show remarkable but short-term success in patients with MDD. Studies in patients with chronic pain have used different ketamine applications for longer time periods. This experience may be relevant for psychiatric indications. AIMS: To review the literature about the dosing regimen, duration, effects and side-effects of oral, intravenous, intranasal and subcutaneous routes of administration of ketamine for treatment-resistant depression and pain...
February 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/26823121/testosterone-modulates-endothelial-progenitor-cells-in-rat-corpus-cavernosum
#9
Insang Hwang, Hyun-Suk Lee, Ho Song Yu, Mi Eun Kim, Jun Sik Lee, Kwangsung Park
OBJECTIVE: To investigate the effects of testosterone on cavernosal endothelial progenitor cells (EPCs) in a castrated rat model. MATERIALS AND METHODS: In all, 45 male Sprague-Dawley rats (12-weeks old) were divided into control, surgical castration, and castration with testosterone replacement groups. The rats were castrated under ketamine anaesthesia, and testosterone was administered by daily subcutaneous injection of 3 mg/kg testosterone propionate. The corpus cavernosum was obtained after perfusion with 10 mL saline via the abdominal aorta 4 weeks later...
June 2016: BJU International
https://www.readbyqxmd.com/read/26520463/role-of-the-nmda-receptor-glun2d-subunit-in-the-expression-of-ketamine-induced-behavioral-sensitization-and-region-specific-activation-of-neuronal-nitric-oxide-synthase
#10
Toshifumi Yamamoto, Tomomi Nakayama, Junji Yamaguchi, Maaya Matsuzawa, Masayoshi Mishina, Kazutaka Ikeda, Hideko Yamamoto
The present study aimed to investigate the involvement of the NMDA receptor (NMDAR) and/or nitric oxide (NO) pathway in ketamine-induced behavioral sensitization. Mice received repeated subcutaneous administration of ketamine (25mg/kg), once daily or once weekly for a total of five doses. Even three administrations of ketamine, daily or weekly, induced a rapid increase in locomotor activity in wild-type (WT), but not in GluN2D knockout (GluN2D-KO) mice. Furthermore, for WT mice receiving daily ketamine, elevated locomotor activity was maintained after a 1-month withdrawal period; however, this was not the case when ketamine was administered weekly...
January 1, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26170642/the-optimal-choice-of-medication-administration-route-regarding-intravenous-intramuscular-and-subcutaneous-injection
#11
REVIEW
Jing-Fen Jin, Ling-Ling Zhu, Meng Chen, Hui-Min Xu, Hua-Fen Wang, Xiu-Qin Feng, Xiu-Ping Zhu, Quan Zhou
BACKGROUND: Intravenous (IV), intramuscular (IM), and subcutaneous (SC) are the three most frequently used injection routes in medication administration. Comparative studies of SC versus IV, IM versus IV, or IM versus SC have been sporadically conducted, and some new findings are completely different from the dosage recommendation as described in prescribing information. However, clinicians may still be ignorant of such new evidence-based findings when choosing treatment methods. METHODS: A literature search was performed using PubMed, MEDLINE, and Web of Sciences™ Core Collection to analyze the advantages and disadvantages of SC, IV, and IM administration in head-to-head comparative studies...
2015: Patient Preference and Adherence
https://www.readbyqxmd.com/read/26161612/subcutaneous-midazolam-with-and-without-ketamine-for-sedation-in-children-undergoing-dental-treatment-a-pilot-study
#12
RANDOMIZED CONTROLLED TRIAL
D Flores-Castillo, R Martínez-Rider, S Ruiz-Rodríguez, A Garrocho-Rangel, J Lara-Guevara, A Pozos-Guillén
AIM: The objective of this study was to evaluate the efficacy of subcutaneous (SC) sedation using midazolam with and without ketamine in non-cooperative pediatric patients undergoing dental treatment. STUDY DESIGN: A prospective, randomized, controlled, double-blind, crossover pilot clinical trial was carried out in 13 children, aged between 17-46 months, ASA l, Frankl 1. Two sedation schemes were administered SC: Midazolam alone (M), and a combination of Midazolam-Ketamine (MK)...
2015: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/26120571/developing-a-commercial-air-ultrasonic-ceramic-transducer-to-transdermal-insulin-delivery
#13
Nasrollah Jabbari, Mohammad Hossein Asghari, Hassan Ahmadian, Peyman Mikaili
The application of low-frequency ultrasound for transdermal delivery of insulin is of particular public interest due to the increasing problem of diabetes. The purpose of this research was to develop an air ultrasonic ceramic transducer for transdermal insulin delivery and evaluate the possibility of applying a new portable and low-cost device for transdermal insulin delivery. Twenty-four rats were divided into four groups with six rats in each group: one control group and three experimental groups. Control group (C) did not receive any ultrasound exposure or insulin (untreated group)...
April 2015: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/26093387/potential-economic-impact-on-hospitalisations-of-the-palliative-care-clinical-studies-collaborative-paccsc-ketamine-randomised-controlled-trial
#14
Nikki McCaffrey, Janet Hardy, Belinda Fazekas, Meera Agar, Linda Devilee, Debra Rowett, David Currow
OBJECTIVE: The aim of the present study was to estimate the potential healthcare cost savings associated with reduced prescribing of subcutaneous ketamine for the treatment of chronic cancer pain after publication of the Palliative Care Clinical Studies Collaborative (PaCCSC) ketamine randomised controlled trial (RCT), to provide further reasons to modify ketamine prescribing practice in this setting. METHODS: Potential cost savings in this setting were estimated from a health system perspective using a 1-year impact model...
February 2016: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/26077661/role-of-the-thalamic-submedius-nucleus-histamine-h1-and-h-2-and-opioid-receptors-in-modulation-of-formalin-induced-orofacial-pain-in-rats
#15
Amir Erfanparast, Esmaeal Tamaddonfard, Mina Taati, Milad Dabaghi
Histamine and opioid systems are involved in supraspinal modulation of pain. In this study, we investigated the effects of separate and combined microinjections of agonists and antagonists of histamine H1 and H2 and opioid receptors into the thalamic submedius (Sm) nucleus on the formalin-induced orofacial pain. Two guide cannulas were implanted into the right and left sides of the Sm in ketamine- and xylazine-anesthetized rats. Orofacial formalin pain was induced by subcutaneous injection of a diluted formalin solution (50 μl, 1...
October 2015: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/25996762/efficacy-of-an-intrathecal-multidrug-infusion-for-pain-control-in-older-adults-and-in-end-stage-malignancies-a-report-of-three-cases
#16
Sadegh Abdolmohammadi, Pierre-Olivier Hétu, Andrée Néron, Gilbert Blaise
The aim of the present study was to explore the effectiveness of an alternative method to manage pain based on a time-limited intrathecal (IT) infusion of an analgesic medication mixture. Three patients (69, 64 and 94 years of age) with intractable and poorly controlled pain due to bed sores, pelvic metastatic mass, and thoracic vertebra and rib fractures, respectively, were treated. Daily doses of opioids could not be increased due to side effects. An IT catheter (20 G) was placed by percutaneous approach in the lumbar area while advancing toward the thoracic region, and was then tunnelled and fixed subcutaneously...
May 2015: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/25800174/long-term-antihyperalgesic-and-opioid-sparing-effects-of-5-day-ketamine-and-morphine-infusion-burst-ketamine-in-diabetic-neuropathic-rats
#17
Plato Mak, Jillian H Broadbear, Anton Kolosov, Colin S Goodchild
BACKGROUND: "Burst ketamine" (BK) is the long-term infusion of subanesthetic ketamine in combination with an opioid. It is used clinically with mixed success to provide long-term pain relief and improve opioid response in patients. BK has not been simulated preclinically, therefore, its effectiveness was investigated in an animal model of neuropathic pain--streptozotocin-induced diabetic neuropathy. METHODS: Diabetic neuropathic rats were randomized to receive a subcutaneous infusion of ketamine 20 mg/kg/day plus morphine 20 mg/kg/day (BK), either drug alone at the same dose, or sham treatment...
September 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/25702819/cyp2b6-6-allele-and-age-substantially-reduce-steady-state-ketamine-clearance-in-chronic-pain-patients-impact-on-adverse-effects
#18
RANDOMIZED CONTROLLED TRIAL
Yibai Li, Kate A Jackson, Barry Slon, Janet R Hardy, Michael Franco, Leeroy William, Peter Poon, Janet K Coller, Mark R Hutchinson, David C Currow, Andrew A Somogyi
AIMS: Ketamine analgesia is limited by low intrinsic efficacy compounded by large interindividual variability in drug responses, possibly due to the heterogeneity in drug concentration. The CYP2B6*6 allele is associated with substantially reduced ketamine metabolism in vitro and, therefore, may affect ketamine clearance. Our aims were to examine the impact of the CYP2B6*6 allele on ketamine plasma clearance and on adverse effects in chronic pain patients. METHODS: CYP2B6 genotypes were identified in 49 chronic pain patients who received 24 h continuous subcutaneous infusions of ketamine...
August 2015: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/25467740/a-case-report-of-dexmedetomidine-used-to-treat-intractable-pain-and-delirium-in-a-tertiary-palliative-care-unit
#19
Neil Hilliard, Stuart Brown, Steve Mitchinson
BACKGROUND: This case report describes an end-stage cancer patient with intractable neuropathic pain and delirium who was successfully managed during the last 3 weeks of her life with a continuous subcutaneous infusion of dexmedetomidine. CASE PRESENTATION: A 55-year-old woman with locally advanced cervical cancer and uncontrolled pelvic pain was admitted to a tertiary palliative care unit for pain management. As her disease progressed, the patient's pelvic pain intensified despite treatment with methadone, gabapentin, ketamine, and hydromorphone administered by continuous subcutaneous infusion plus frequent breakthrough doses of hydromorphone and sufentanil...
March 2015: Palliative Medicine
https://www.readbyqxmd.com/read/25423366/effects-of-anesthetics-on-the-renal-sympathetic-response-to-anaphylactic-hypotension-in-rats
#20
Lingling Sun, Mamoru Tanida, Mofei Wang, Yuhichi Kuda, Yasutaka Kurata, Toshishige Shibamoto
The autonomic nervous system plays an important role in rat anaphylactic hypotension. It is well known that sympathetic nerve activity and cardiovascular function are affected by anesthetics. However, the effects of different types of anesthesia on the efferent renal sympathetic nerve activity (RSNA) during anaphylactic hypotension remain unknown. Therefore, we determined the renal sympathetic responses to anaphylactic hypotension in anesthetized and conscious rats and the roles of baroreceptors in these responses...
2014: PloS One
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