Noha Sharafeldin, Liting Zhou, Purnima Singh, David K Crossman, Xuexia Wang, Lindsey Hageman, Wendy Landier, Javier G Blanco, Paul W Burridge, Yadav Sapkota, Yutaka Yasui, Gregory T Armstrong, Leslie L Robison, Melissa M Hudson, Kevin Oeffinger, Eric J Chow, Saro H Armenian, Daniel J Weisdorf, Smita Bhatia
BACKGROUND: Anthracyclines are highly effective in treating cancer, albeit with increased cardiomyopathy risk. Although risk is attributed to associations with single nucleotide polymorphisms (SNPs), multiple SNPs on a gene and their interactions remain unexamined. OBJECTIVES: This study examined gene-level associations with cardiomyopathy among cancer survivors using whole-exome sequencing data. METHODS: For discovery, 278 childhood cancer survivors (129 cases; 149 matched control subjects) from the COG (Children's Oncology Group) study ALTE03N1 were included...
December 2023: JACC CardioOncology