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https://www.readbyqxmd.com/read/27845288/evaluation-of-the-use-of-ozone-therapy-in-treatment-of-inflammatory-processes-in-diabetes-mellitus-in-an-experiment
#1
S Karatieieva, O Yurkiv, S Semenenko, I Kozlovskaya, S Yakobchuk
Studying the effect of ozone therapy on the course of pyoinflammatory processes with diabetes mellitus in the experiment, conducted on 30 white 24-30 month rats, weight 300-450 gr with purulent-inflammatory processes, it was found out that diabetes, which was simulated by subcutaneous injection of alloxan, causes mosaic disturbances of hemostasis system in the presence of pyoinflammatory processes. Complicated changes in blood condition were also detected against the background of diabetes mellitus: chronometric hypocoagulation on the intrinsic pathway of blood coagulation in association with chronometric hypercoagulation by the external thrombinogenesis mechanism and fibrinogenesis depression against the background of hypofibrinogenaemia...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27744376/ampk-activation-by-peri-sciatic-nerve-administration-of-ozone-attenuates-cci-induced-neuropathic-pain-in-rats
#2
Lijuan Lu, Cailong Pan, Lu Chen, Liang Hu, Chaoyu Wang, Yuan Han, Zhixiang Cheng, Yanjing Yang, Wen-Tao Liu
Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting development of novel therapeutics. Ozone is widely used as an alternative therapy for many different pain conditions, with exact mechanisms still elusive. In this study, we found that a single peri-sciatic nerve injection of ozone decreased mechanical allodynia and thermal hyperalgesia, and normalized the phosphorylation of protein kinase C γ (PKCγ), N-methyl-D-aspartate receptor (NMDAR), and extracellular signal-regulated kinase in a chronic constriction injury (CCI) model in rat sciatic nerve...
October 15, 2016: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/27737405/methylene-blue-to-treat-protamine-induced-anaphylaxis-reactions-an-experimental-study-in-pigs
#3
Agnes Afrodite S Albuquerque, Edson A Margarido, Antonio Carlos Menardi, Adilson Scorzoni, Andrea Carla Celotto, Alfredo J Rodrigues, Walter Vilella A Vicente, Paulo Roberto B Evora
Objective: To examine if methylene blue (MB) can counteract or prevent protamine (P) cardiovascular effects. Methods: The protocol included five heparinized pig groups: Group Sham -without any drug; Group MB - MB 3 mg/kg infusion; Group P - protamine; Group P/MB - MB after protamine; Group MB/P - MB before protamine. Nitric oxide levels were obtained by the nitric oxide/ozone chemiluminescence method, performed using the Nitric Oxide Analizer 280i (Sievers, Boulder, CO, USA)...
May 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27727399/tissue-plasminogen-activator-as-an-antiangiogenic-agent-in-experimental-laser-induced-choroidal-neovascularization-in-mice
#4
Daisuke Ozone, Takeshi Mizutani, Miho Nozaki, Masaharu Ohbayashi, Norio Hasegawa, Aki Kato, Tsutomu Yasukawa, Yuichiro Ogura
Purpose: We investigate the antiangiogenic efficacy of tissue plasminogen activator (tPA) on experimental laser-induced choroidal neovascularization (CNV) in mice. Methods: After CNV was induced by laser photocoagulation in 92 C57BL/6J wild-type mice, tPA (4 or 40 international units [IU]/μl) or PBS was injected intravitreally immediately after laser injury. Fluorescein angiography was performed on day 7 to grade CNV leakage. The CNV volume was measured by confocal microscopy in eyes enucleated 7 days after laser injury...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27722430/solution-processed-nickel-oxide-nanoparticles-with-niooh-for-hole-injection-layers-of-high-efficiency-organic-light-emitting-diodes
#5
Jeonggi Kim, Hui Joon Park, Costas P Grigoropoulos, Daeho Lee, Jin Jang
Nickel oxide (NiOx) nanoparticles (NPs) were synthesized by a solution-based method and NP films were used as hole injection layers (HILs) in organic light-emitting diodes (OLEDs). To evaluate the hole injection functionality of the NiOx NP HIL, we compared the performance of OLEDs with three types of HILs: spin-coated PEDOT:PSS, thermally evaporated HAT-CN, and spin-coated NiOx NP films. The considerably high component ratio of NiOOH on the air-annealed NiOx NP film surface results in an enhanced hole injection functionality even without UV-ozone treatment...
October 14, 2016: Nanoscale
https://www.readbyqxmd.com/read/27721477/the-1257-samalas-eruption-lombok-indonesia-the-single-greatest-stratospheric-gas-release-of-the-common-era
#6
Céline M Vidal, Nicole Métrich, Jean-Christophe Komorowski, Indyo Pratomo, Agnès Michel, Nugraha Kartadinata, Vincent Robert, Franck Lavigne
Large explosive eruptions inject volcanic gases and fine ash to stratospheric altitudes, contributing to global cooling at the Earth's surface and occasionally to ozone depletion. The modelling of the climate response to these strong injections of volatiles commonly relies on ice-core records of volcanic sulphate aerosols. Here we use an independent geochemical approach which demonstrates that the great 1257 eruption of Samalas (Lombok, Indonesia) released enough sulphur and halogen gases into the stratosphere to produce the reported global cooling during the second half of the 13th century, as well as potential substantial ozone destruction...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27666722/greater-occipital-nerve-block-in-the-treatment-of-triptan-overuse-headache-a-randomized-comparative-study
#7
Ö Karadaş, A Ö Özön, F Özçelik, A Özge
OBJECTIVES: This study aims to investigate the efficiency of a single and repeated greater occipital nerve (GON) block using lidocaine in the treatment of triptan-overuse headache (TOH), whose importance has increased lately. MATERIALS AND METHODS: In the study, 105 consecutive subjects diagnosed with TOH were evaluated. The subjects were randomized into three groups. In Group 1 (n=35), only triptan was abruptly withdrawn. In Group 2 (n=35), triptan was abruptly withdrawn and single GON block was performed...
September 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27464625/the-protective-effects-of-human-umbilical-cord-mesenchymal-stem-cells-on-damaged-ovarian-function-a-comparative-study
#8
Jinjin Zhang, Jiaqiang Xiong, Li Fang, Zhiyong Lu, Meng Wu, Liangyan Shi, Xian Qin, Aiyue Luo, Shixuan Wang
Numerous studies have reported that human umbilical cord mesenchymal stem cell (hUCMSC) therapy can rescue the structure and function of injured tissues. The aims of this study were to explore the protective role of hUCMSC transplantation in a model of accelerated ovarian aging and to compare 2 methods of transplanting hUCMSCs, i.e. i) via intravenous injection (IV) and ii) in situ ovarian micro injection (MI). Female mice were subjected to superovulation and ozone inhalation to create a model of accelerated ovarian aging with a decline in both the quantity and quality of oocytes...
September 5, 2016: Bioscience Trends
https://www.readbyqxmd.com/read/27380433/role-of-neutralizing-anti-murine-interleukin-17a-monoclonal-antibody-on-chronic-ozone-induced-airway-inflammation-in-mice
#9
Min Zhang, Xia Fei, Guo-Qing Zhang, Peng-Yu Zhang, Feng Li, Wu-Ping Bao, Ying-Ying Zhang, Xin Zhou
Exposure to ozone has led to airway inflammation and airway hyperresponsiveness, which potential mechanisms relate to ozone-induced oxidative stress. IL-17 is a growing target for autoimmune and inflammatory diseases. The aim of the study was to examine the inhibitory effects of anti-murine interleukin-17A monoclonal antibody (IL-17mAb) on adverse effects of ozone which are noted above. After C57/BL6 mice were exposed to ozone (2.5ppm; 3h) for 12 times over 6 weeks, IL-17mAb, PBS was intraperitoneally injected into mice 1h after ozone or air exposure for 6 weeks and mice were studied 24h after final exposure, monitoring bronchial responsiveness, airway inflammatory cells, lung histology, levels of neutrophil-related chemokine and proinflammatory cytokines in bronchoalveolar lavage (BAL) fluid and serum, the expression of IL-17A mRNA and protein, glucocorticoid receptors (GR), and the phosphorylation of p38MAPK in lung tissues...
July 2, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27366680/histopathological-changes-in-retinas-and-f-erg-features-of-streptozotocin-induced-diabetic-rats-treated-with-ozone
#10
Ting-Yu Xie, Qin Li, Xue-Yi Chen
AIM: To study the histopathological changes in the retina and flash electroretinogram (F-ERG) features of ozone-treated streptozotocin (STZ)-induced diabetic rats. METHODS: Seventy male Sprague Dawley rats were grouped as follows: blank group (GB, n=10), model control group (GM, n=18), ozone group (GO3, n=19), and oxygen group (GO2, n=18). The model was induced by single intraperitoneal injection of STZ. Ozone or oxygen enteroclysm was given twice per week for 4wk...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27358159/comparison-between-intrarticular-injection-of-hyaluronic-acid-oxygen-ozone-and-the-combination-of-both-in-the-treatment-of-knee-osteoarthrosis
#11
RANDOMIZED CONTROLLED TRIAL
A Giombini, F Menotti, A Di Cesare, F Giovannangeli, M Rizzo, S Moffa, F Martinelli
This study aimed to compare short-term clinical outcomes between intra-articular injection of hyaluronic acid (HA), oxygen ozone (O2O3), and the combination of both, in patients affected by osteoarthrosis (OA) of the knee. Seventy patients (age 45-75 years) with knee OA were randomized to intra-articular injections of HA (n=23), or O2O3 (n=23) or combined (n=24) one per week for 5 consecutive weeks. KOOS questionnaire and visual analog scale (VAS), before treatment (pre) at the end (post), and at 2 months after treatment ended (follow-up) were used as outcome measures...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27323014/effect-of-ozone-on-vascular-endothelial-growth-factor-vegf-and-related-inflammatory-cytokines-in-rats-with-diabetic-retinopathy
#12
T Y Xie, W Yan, J Lou, X Y Chen
The aim of this study was to investigate the effect of ozone on inflammatory cytokines in diabetic retinopathy (DR) rats. Male rats (40) weighing 300-360 g were included in this study. Thirty rats were randomly divided into the model and ozone groups after DR was induced by streptozotocin. Ten rats served as the blank group. After the diabetic models were established for one month, the rats in the ozone group were treated with 50 mg/kg ozone coloclysis for one month (three times a week). After the rats were anesthetized by intraperitoneal injection, blood samples from the abdominal aorta were collected, and the supernatant was obtained by centrifugation...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27232995/determination-of-oxidant-exposure-during-ozonation-of-secondary-effluent-to-predict-contaminant-removal
#13
Ines Zucker, Dror Avisar, Hadas Mamane, Martin Jekel, Uwe Hübner
The use of kinetic models to predict oxidation performance in wastewater is limited due to fast ozone depletion during the first milliseconds of the reaction. This paper introduces the Quench Flow Module (QFM), a bench-scale experimental technique developed to measure the first 5-500 milliseconds of ozone depletion for accurate determination of ozone exposure in wastewater-ozonation processes. Calculated ozone exposure in QFM experiments was up to 24% lower than in standard batch experiments, strongly depending on the initial sampling point for measurement in batch experiments...
September 1, 2016: Water Research
https://www.readbyqxmd.com/read/27230423/assessing-ambient-ozone-injury-in-olive-olea-europaea-l-plants-by-using-the-antioxidant-ethylenediurea-edu-in-saudi-arabia
#14
J M Basahi, I M Ismail, N S Haiba, I A Hassan, G Lorenzini
The antiozonant chemical, ethylenediurea (N-[2-(2-oxo-1-imidazolidinyl)ethyl]-N'-phenylurea, abbreviated as EDU), was applied as stem injections or soil drenches to 5-year-old containerized plants of olive (Olea europaea L. cultivar Kalamata) in growth chambers in order to assess its ameliorative effects against realistic ozone (O3) stress. Visible injury symptoms were reduced greatly in individuals treated with EDU, with injection applications having greater protection than soil drenches. EDU application caused increases in the measured ecophysiological parameters compared to untreated individuals...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27221387/effects-of-ozone-o3-therapy-on-cisplatin-induced-ototoxicity-in-rats
#15
Hasan Emre Koçak, Ümit Taşkın, Salih Aydın, Mehmet Faruk Oktay, Serdar Altınay, Duygu Sultan Çelik, Kadir Yücebaş, Bengül Altaş
The aim of this study is to investigate the effect of rectal ozone and intratympanic ozone therapy on cisplatin-induced ototoxicity in rats. Eighteen female Wistar albino rats were included in our study. External auditory canal and tympanic membrane examinations were normal in all rats. The rats were randomly divided into three groups. Initially, all the rats were tested with distortion product otoacoustic emissions (DPOAE), and emissions were measured normally. All rats were injected with 5-mg/kg/day cisplatin for 3 days intraperitoneally...
May 24, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27203618/effect-of-ambient-temperature-on-total-organic-gas-speciation-profiles-from-light-duty-gasoline-vehicle-exhaust
#16
Anirban Roy, Darrell Sonntag, Richard Cook, Catherine Yanca, Charles Schenk, Yunsoo Choi
Total organic gases (TOG) emissions from motor vehicles include air toxic compounds and contribute to formation of ground-level ozone and secondary organic aerosol (SOA). These emissions are known to be affected by temperature; however previous studies have typically focused only on the temperature dependence of total emission factors and select toxic compounds. This study builds on the previous research by performing an evaluation of a comprehensive set of gas-phase organic compounds present in gasoline motor vehicle exhaust...
June 21, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27153523/graphene-oxide-graphene-vertical-heterostructure-electrodes-for-highly-efficient-and-flexible-organic-light-emitting-diodes
#17
S Jia, H D Sun, J H Du, Z K Zhang, D D Zhang, L P Ma, J S Chen, D G Ma, H M Cheng, W C Ren
The relatively high sheet resistance, low work function and poor compatibility with hole injection layers (HILs) seriously limit the applications of graphene as transparent conductive electrodes (TCEs) for organic light emitting diodes (OLEDs). Here, a graphene oxide/graphene (GO/G) vertical heterostructure is developed as TCEs for high-performance OLEDs, by directly oxidizing the top layer of three-layer graphene films with ozone treatment. Such GO/G heterostructure electrodes show greatly improved optical transmittance, a large work function, high stability, and good compatibility with HIL materials (MoO3 in this work)...
May 19, 2016: Nanoscale
https://www.readbyqxmd.com/read/27136444/therapeutic-effect-of-ozone-and-rutin-on-adriamycin-induced-testicular-toxicity-in-an-experimental-rat-model
#18
E A Salem, N A Salem, W J Hellstrom
To evaluate the cytoprotective effects of rutin, ozone and their combination on adriamycin (ADR)-induced testicular toxicity, 50 male albino rats were classified into five groups of ten animals each as follows: placebo group; ADR group; ADR + rutin group; ADR + ozone group and ADR + rutin + ozone group. Sperm functions, testosterone (T), luteinising hormone (LH), follicle stimulating hormone (FSH), testicular enzymes, oxidant/antioxidant status, C-reactive protein, monocyte chemoattractant proteins-1 and leukotriene B4 were determined...
May 2, 2016: Andrologia
https://www.readbyqxmd.com/read/27095293/impact-of-biological-treatments-of-bio-waste-for-nutrients-energy-and-bio-methane-recovery-in-a-life-cycle-perspective
#19
Francesco Di Maria, Caterina Micale, Stefano Contini, Emanuela Morettini
Composting of the source-segregated organic fraction of municipal solid waste was compared in a life cycle perspective with conventional anaerobic digestion (AD), aimed at electricity substitution, and with AD aimed at biogas upgrading into bio-methane. Three different uses of the bio-methane were considered: injection in the natural gas grid for civil heating needs; use as fuel for high efficiency co-generation; use as fuel for vehicles. Scenarios with biogas upgrading showed quite similar impact values, generally higher than those of composting and conventional AD, for which there was a lower impact...
June 2016: Waste Management
https://www.readbyqxmd.com/read/27056686/choice-of-intra-articular-injection-in-treatment-of-knee-osteoarthritis-platelet-rich-plasma-hyaluronic-acid-or-ozone-options
#20
Tahir Mutlu Duymus, Serhat Mutlu, Bahar Dernek, Baran Komur, Suavi Aydogmus, Fatma Nur Kesiktas
PURPOSE: This study was performed to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given an intra-articular injection of platelet-rich plasma (PRP), hyaluronic acid (HA) or ozone gas. METHODS: A total of 102 patients with mild-moderate and moderate knee OA who presented at the polyclinic with at least a 1-year history of knee pain and VAS score ≥4 were randomly separated into three groups. Group 1 (PRP group) received intra-articular injection of PRP × 2 doses, Group 2 (HA group) received a single dose of HA, and Group 3 (Ozone group) received ozone × four doses...
April 7, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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