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https://www.readbyqxmd.com/read/29666436/alterations-in-the-health-of-hibernating-bats-under-pathogen-pressure
#1
Hana Bandouchova, Tomáš Bartonička, Hana Berkova, Jiri Brichta, Tomasz Kokurewicz, Veronika Kovacova, Petr Linhart, Vladimir Piacek, Jiri Pikula, Alexandra Zahradníková, Jan Zukal
In underground hibernacula temperate northern hemisphere bats are exposed to Pseudogymnoascus destructans, the fungal agent of white-nose syndrome. While pathological and epidemiological data suggest that Palearctic bats tolerate this infection, we lack knowledge about bat health under pathogen pressure. Here we report blood profiles, along with body mass index (BMI), infection intensity and hibernation temperature, in greater mouse-eared bats (Myotis myotis). We sampled three European hibernacula that differ in geomorphology and microclimatic conditions...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665434/differential-growth-of-mycobacterium-leprae-strains-snp-genotypes-in-armadillos
#2
Rahul Sharma, Pushpendra Singh, Maria Pena, Ramesh Subramanian, Vladmir Chouljenko, Joohyun Kim, Nayong Kim, John Caskey, Marie A Baudena, Linda B Adams, Richard W Truman
Leprosy (Hansen's Disease) has occurred throughout human history, and persists today at a low prevalence in most populations. Caused by Mycobacterium leprae, the infection primarily involves the skin, mucosa and peripheral nerves. The susceptible host range for Mycobacterium leprae is quite narrow. Besides humans, nine banded armadillos (Dasypus novemcinctus) and red squirrels (Sciurus vulgaris) are the only other natural hosts for M. leprae, but only armadillos recapitulate the disease as seen in humans. Armadillos across the Southern United States harbor a single predominant genotypic strain (SNP Type-3I) of M...
April 14, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29664544/human-skin-model-for-mimic-dermal-studies-in-pathology-with-a-clinical-implication-in-pressure-ulcers
#3
Lara Cristóbal, Miguel A Ortega, Ángel Asúnsolo, Beatriz Romero, Melchor Álvarez-Mon, Julia Buján, Andrés A Maldonado, Natalio García-Honduvilla
Despite advances in regenerative medicine and tissue engineering, human skin substitutes remain a clear goal to achieve. Autografts remain the principal clinical option. The long-term changes in dermis, as well as its response after injuries, are not well known. Research in this field has been hindered by a lack of experimental animal models. This study analyzes the architectural dermal scaffold (collagen and elastin fibers plus fibrillin-microfibrils) changes in a model of human skin pressure ulcers in mice...
April 17, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29664513/vitiligo-type-cutaneous-manifestation-of-chronic-graft-versus-host-disease-case-report
#4
Karla Gálvez, Paula Muñoz, Valentina Vera, Claudio Arce
INTRODUCTION: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664231/oxidative-stress-in-the-pathogenesis-of-systemic-scleroderma-an-overview
#5
REVIEW
Rosa Vona, Antonello Giovannetti, Lucrezia Gambardella, Walter Malorni, Donatella Pietraforte, Elisabetta Straface
Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability and death as the result of end-stage organ failure. Two clinical subsets of the SSc are accepted: limited cutaneous SSc (lc-SSc) and diffuse cutaneous SSc (dc-SSc). At present, the aetiology and pathogenesis of SSc remain obscure, and consequently, disease outcome is unpredictable...
April 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29663354/the-management-of-livedoid-vasculopathy-focused-on-direct-oral-anticoagulants-doacs-four-case-reports-successfully-treated-with-rivaroxaban
#6
Gabriela Franco Marques, Paulo Ricardo Criado, Thâmara Cristiane Alves Batista Morita, María Salomé Cajas García
Livedoid vasculopathy (LV) is a thrombotic skin disease characterized by episodic painful ulcerations of the distal aspects of the legs. Its healing process typically leaves small porcelain-white scars called atrophie blanche as a result of the occlusion of cutaneous microcirculation. The main goals of the treatment are pain management and the prevention of ulceration and of progressive scarring in the malleolar area. The therapeutic management is still a challenge, however, and most treatments were based on anecdotal off-label protocols...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29662201/differential-glucose-requirement-in-skin-homeostasis-and-injury-identifies-a-therapeutic-target-for-psoriasis
#7
Zhuzhen Zhang, Zhenzhen Zi, Eunice E Lee, Jiawei Zhao, Diana C Contreras, Andrew P South, E Dale Abel, Benjamin F Chong, Travis Vandergriff, Gregory A Hosler, Philipp E Scherer, Marcel Mettlen, Jeffrey C Rathmell, Ralph J DeBerardinis, Richard C Wang
Proliferating cells, compared with quiescent cells, are more dependent on glucose for their growth. Although glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, we found that keratinocyte-specific ablation of Glut1 did not compromise mouse skin development and homeostasis. Ex vivo metabolic profiling revealed altered sphingolipid, hexose, amino acid, and nucleotide metabolism in Glut1-deficient keratinocytes, thus suggesting metabolic adaptation. However, cultured Glut1-deficient keratinocytes displayed metabolic and oxidative stress and impaired proliferation...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29661122/lymphocytic-mural-folliculitis-resembling-epitheliotropic-lymphoma-in-tigers-panthera-tigris
#8
Mee-Ja M Sula, Linda A Frank, Edward C Ramsay
A striking form of lymphocytic mural folliculitis is described in 6 tigers ( Panthera tigris). Clinically, all tigers exhibited regionally extensive chronic, variably waxing and waning alopecia with minimal scaling and crusting most pronounced over the head, neck, and shoulders. More severely affected tigers exhibited marked hyperpigmentation and lichenification. Pruritus was not a feature. Tigers generally lacked signs of systemic illness and clinical pathology findings were unremarkable. Histologic examination of skin biopsies revealed infiltrative lymphocytic mural folliculitis extending the length of the hair follicle...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29660532/imaging-in-testicular-epidermoid-cysts
#9
Renwei Liu, Zhengxian Lei, Nengxue Chen, Jinzhi Fang, Yuzhong Zhang
OBJECTIVE: To evaluate the utility of findings on ultrasound and magnetic resonance imaging (MRI) for the preoperative diagnosis of testicular epidermoid cysts (TEC). METHODS: The medical records of five patients treated for TEC at our institution between July 2010 and May 2017 were retrospectively reviewed. RESULTS: Imaging revealed a target or onion skin appearance on ultrasonography and MRI. Pathological examinations showed "bread slag-like" materials within the TEC...
April 5, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29658918/whole-mount-confocal-microscopy-for-adult-ear-skin-a-model-system-to-study-neuro-vascular-branching-morphogenesis-and-immune-cell-distribution
#10
Tomoko Yamazaki, Wenling Li, Yoh-Suke Mukouyama
Here, we present a protocol of a whole-mount adult ear skin imaging technique to study comprehensive three-dimensional neuro-vascular branching morphogenesis and patterning, as well as immune cell distribution at a cellular level. The analysis of peripheral nerve and blood vessel anatomical structures in adult tissues provides some insights into the understanding of functional neuro-vascular wiring and neuro-vascular degeneration in pathological conditions such as wound healing. As a highly informative model system, we have focused our studies on adult ear skin, which is readily accessible for dissection...
March 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29658451/-clinical-and-genetic-analysis-of-a-pediatric-patient-with-sodium-taurocholate-cotransporting-polypeptide-deficiency
#11
Hua Li, Jian-Wu Qiu, Gui-Zhi Lin, Mei Deng, Wei-Xia Lin, Ying Cheng, Yuan-Zong Song
Sodium taurocholate cotransporting polypeptide (NTCP) deficiency is an inborn error of bile acid metabolism caused by mutations of SLC10A1 gene. This paper reports the clinical and genetic features of a patient with this disease. A 3.3-month-old male infant was referred to the hospital with the complaint of jaundiced skin and sclera over 3 months. Physical examination revealed moderate jaundice of the skin and sclera. The liver was palpable 3.5 cm below the right subcostal margin with a medium texture. Serum biochemistry analysis revealed markedly elevated bilirubin (predominantly direct bilirubin) and total bile acids (TBA), as well as decreased 25-OH-VitD level...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29658140/texture-analysis-of-second-harmonic-generation-images-for-quantitative-analysis-of-reticular-dermal-collagen-fiber-in-vivo-in-human-facial-cheek-skin
#12
Yuki Ogura, Yuji Tanaka, Eiji Hase, Toyonobu Yamashita, Takeshi Yasui
Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo visualization of collagen fibers in human skin because of its specific collagen selectivity without the need for staining, non-invasiveness, and high-resolution three-dimensional imaging. Although texture analysis of SHG images is a promising method for the quantitative analysis of well-orientated collagen fiber structure in the tendon and cornea, there are few attempts to assess cutaneous aging. In this study, we applied two texture analysis techniques, namely auto-correlation (2D-AC) analysis and two-dimensional Fourier transform (2D-FT), to evaluate the age-dependent changes in reticular dermal collagen fibers in in vivo human cheek skin...
April 15, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29656841/from-phaeohyphomycosis-to-disseminated-chromoblastomycosis-a-retrospective-study-of-infections-caused-by-dematiaceous-fungi
#13
E Thomas, A Bertolotti, A Barreau, J Klisnick, P Tournebize, G Borgherini, N Zemali, J Jaubert, G Jouvion, S Bretagne, S Picot
OBJECTIVE: Infections caused by dematiaceous fungi are more common in tropical and subtropical areas. We aimed to describe the clinical, microbiological and therapeutic aspects of case patients diagnosed at a University Hospital located on an Indian Ocean island. PATIENTS AND METHODS: We performed an observational retrospective study of infections caused by dematiaceous fungi diagnosed at the University Hospital of Saint-Pierre, Reunion, from 2000 to 2015. Mycological identifications were performed at the National Reference Center for Invasive Mycosis and Antifungal Agents (Paris)...
April 12, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29653385/histological-and-ultrastructural-alterations-of-the-italian-newt-lissotriton-italicus-skin-after-exposure-to-ecologically-relevant-concentrations-of-nonylphenol-ethoxylates
#14
Elvira Brunelli
Nonylphenol ethoxylates (NPEs) are well known endocrine disruptors. Widespread environmental contamination from NPEs is an issue of great concern. Despite amphibians are often exposed to such contaminants, very little attention has been dedicated to this vertebrate group. No information is available on the effects of NPEs onto the amphibian skin and only few reports have been conducted on fish. Here, histological and ultrastructural modifications of the skin have been evaluated in the Italian newt Lissotriton italicus...
April 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29652047/-physical-therapy-of-psoriasis-the-modern-methodological-approaches
#15
I S Evstigneeva, A G Kulikov, O V Yarustovskaya, A S Shakhova, M G Lutoshkina
This article describes the modern approaches to the application of physical factors for the treatment of various forms of psoriasis taking into consideration the severity of clinical manifestations and the phase of the disease, the extent of disturbances of the functional state of different organs. The principles of prescription of physiotherapeutictreatmnt are formulated taking account of the stages and forms of the disease. Special attention is paid to the high therapeutic effectiveness of ultraviolet irradiation of the skin including narrow-band UVВ (311 nm) as well as to photodynamic therapy (PUVA), intravenous laser irradiation of blood, and ozone therapy...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29649431/diagnosis-and-management-of-children-with-mycobacterium-abscessus-infections-in-the-head-and-neck
#16
Justine Moe, Roy Rajan, Shelley Caltharp, Shelly Abramowicz
PURPOSE: Controversy exists regarding the most appropriate treatment strategy for children with nontuberculous mycobacterial (NTM) cervical lymphadenitis. Mycobacterium abscessus (MAB) is an uncommon cause of NTM cervical lymphadenitis. The purpose of the present study was to evaluate diagnosis, management, and treatment outcomes in children with MAB-associated cervical lymphadenitis resulting from a pulpotomy. MATERIALS AND METHODS: This was a retrospective chart review of children with NTM lymphadenitis of the head and neck caused by MAB treated at Children's Healthcare of Atlanta hospitals (Atlanta, GA)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29648985/feasibility-of-telemetric-intracranial-pressure-monitoring-in-the-neuro-intensive-care-unit
#17
Alexander Lilja-Cyron, Jesper Kelsen, Morten Andresen, Kåre Fugleholm, Marianne Juhler
Intracranial pressure (ICP) monitoring is crucial in the management of acute neurosurgical conditions such as traumatic brain injury (TBI). However, pathological ICP may persist beyond the admission to the neuro intensive care unit (NICU). We investigated the feasibility of telemetric ICP monitoring in the NICU, as this technology provides the possibility of long-term ICP assessment beyond NICU discharge. In this prospective investigation, we implanted telemetric ICP sensors (Raumedic Neurovent-P-tel) instead of conventional, cabled ICP sensors in patients undergoing decompressive craniectomy...
March 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29648673/structured-diagnostic-approach-and-risk-assessment-in-mucous-membrane-pemphigoid-with-oesophageal-involvement
#18
Sandrine Benoit, Michael Scheurlen, Matthias Goebeler, Johanna Stoevesandt
Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29644941/role-of-micrornas-in-treatment-response-in-prostate-cancer
#19
Anshuli Razdan, Paul de Souza, Tara Laurie Roberts
Prostate cancer (PCa) is the most common non-skin cancer in men worldwide, resulting in significant mortality and morbidity. Depending on the grade and stage of the cancer, patients may be given radiation therapy, hormonal therapy, or chemotherapy. However, more than half these patients develop resistance to treatment, leading to disease progression and metastases, often with lethal consequences. MicroRNAs (miRNAs) are short, non-coding RNAs, which regulate numerous physiological as well as pathological processes, including cancer...
March 15, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29642833/-management-and-treatment-difficulties-of-multi-drug-resistant-pulmonary-tuberculosis-in-a-pediatric-case
#20
Selda Hançerli Törün, Emine Manolya Acar, Ayper Somer, Gonca Erköse, Dilek Şatana, Zuhal Bayramoğlu, Emine Çalışkan, Zeki Kılıçaslan
Tuberculosis continues to be a major health problem worldwide. Multidrug resistant tuberculosis (MDR-TB) infection that occurs in childhood is caused by adult MDR-TB agents which are in circulation and resistant to primary drugs. In this case report a 17-month-old child with MDR-TB who was cured after a 24-month therapy regimen was presented. Physical examination of a 17-month-old girl admitted to the hospital with the cause of recurrent pneumonia revealed a rubbery lymphadenopathy less than 2 cm in the right upper cervical region...
January 2018: Mikrobiyoloji Bülteni
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