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Preterm birth biomarker

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https://www.readbyqxmd.com/read/28198381/bio-functionalized-magnetic-nanoparticles-for-the-immunoassay-of-fetal-fibronectin-a-feasibility-study-for-the-prediction-of-preterm-birth
#1
Chian-Huey Wong, Chie-Pein Chen, Chia-Chen Chang, Chen-Yu Chen
Preterm birth is an important cause of perinatal morbidity and mortality. Various biomarkers in cervicovaginal secretions related to preterm birth have been investigated, of which foetal fibronectin (fFN) shows the greatest potential because of its high negative predictive value. The immunomagnetic reduction (IMR) assay has emerged as a novel quantitative method to detect biomarkers. In this prospective case-control study, we analysed 33 samples of cervicovaginal secretions from pregnant women between 22 and 34 weeks of gestation at high risk of preterm birth...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183829/retinal-structure-assessed-by-oct-as-a-biomarker-of-brain-development-in-children-born-small-for-gestational-age
#2
Victoria Pueyo, Teresa Pérez, Inmaculada González, Irene Altemir, Galadriel Gimenez, Esther Prieto, Cristina Paules, Daniel Oros, Javier Lopez-Pison, Nicolás Fayed, Gracián Garcia-Martí, Roberto Sanz-Requena, Miguel Angel Marin
PURPOSE: To identify differences in neuronal tissue from retinal and brain structures in children born small for gestational age (SGA) with no abnormality in neonatal brain ultrasonography and no previous neurological impairment, and to evaluate the relationship between retinal structure and brain changes in school-age children born SGA. METHODS: Two cohorts of children were recruited: 25 children born SGA and 25 children born with an appropriate birth weight according to gestational age...
February 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28170188/endothelial-progenitor-cells-as-prognostic-markers-of-preterm-birth-associated-complications
#3
Mariane Bertagnolli, Anne Monique Nuyt, Bernard Thébaud, Thuy Mai Luu
Preterm birth is associated with alteration of the vascular tree that can result in disease states such as bronchopulmonary dysplasia and retinopathy of prematurity during the neonatal period and emphysema and hypertension in adulthood. Studies have suggested a potential role for endothelial progenitor cells in the pathophysiology of prematurity-related complications involving blood vessels; however, this knowledge has never been synthesized. We conducted a systematic review of the published data to examine the characteristics of endothelial progenitor cells in relation to preterm birth in humans...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28165855/genome-wide-dna-methylation-associations-with-spontaneous-preterm-birth-in-us-blacks-findings-in-maternal-and-cord-blood-samples
#4
Xiumei Hong, Ben Sherwood, Christine Ladd-Acosta, Shouneng Peng, Hongkai Ji, Ke Hao, Irina Burd, Tami R Bartell, Guoying Wang, Hui-Ju Tsai, Xin Liu, Yuelong Ji, Anastacia Wahl, Deanna Caruso, Aviva Lee-Parritz, Barry Zuckerman, Xiaobin Wang
Preterm birth (PTB) affects one in six U.S. Black babies. Epigenetics is believed to play a role in PTB; however, only a limited number of epigenetic studies of PTB have been reported, most of which have focused on cord blood DNA methylation (DNAm) and/or were conducted in white populations. Here we conducted, by far, the largest epigenome-wide DNAm analysis in 300 Black women who delivered early spontaneous preterm (sPTB, n = 150) or full-term babies (n = 150) and replicated the findings in an independent set of Black mother-newborn pairs from the Boston Birth Cohort...
February 6, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28159311/intestinal-barrier-maturation-in-very-low-birthweight-infants-relationship-to-feeding-and-antibiotic-exposure
#5
Bushra Saleem, Adora C Okogbule-Wonodi, Alessio Fasano, Laurence S Magder, Jacques Ravel, Shiv Kapoor, Rose M Viscardi
OBJECTIVE: To test the hypothesis that feeding and antibiotic exposures affect intestinal barrier maturation in preterm infants, we serially measured intestinal permeability (IP) biomarkers in infants <33 weeks gestation (gestational age [GA]) during the first 2 weeks of life. STUDY DESIGN: Eligible infants <33 weeks GA were enrolled within 4 days of birth in a prospective study of IP biomarkers (NCT01756040). Study participants received the nonmetabolized sugars lactulose/rhamnose enterally on study days 1, 8, and 15 and lactulose/rhamnose were measured in urine by high-performance liquid chromatography...
January 31, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28157383/biomarkers-of-oxidative-stress-in-pregnancy-complications
#6
James Sm Cuffe, Ziheng Calvin Xu, Anthony V Perkins
Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28132814/deficits-in-top-down-sensory-prediction-in-infants-at-risk-due-to-premature-birth
#7
Lauren L Emberson, Alex M Boldin, Julie E Riccio, Ronnie Guillet, Richard N Aslin
A prominent theoretical view is that the brain is inherently predictive [1, 2] and that prediction helps drive the engine of development [3, 4]. Although infants exhibit neural signatures of top-down sensory prediction [5, 6], in order to establish that prediction supports development, it must be established that deficits in early prediction abilities alter trajectories. We investigated prediction in infants born prematurely, a leading cause of neuro-cognitive impairment worldwide [7]. Prematurity, independent of medical complications, leads to developmental disturbances [8-12] and a broad range of developmental delays [13-17]...
February 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28120286/adverse-perinatal-outcomes-and-postpartum-multi-systemic-dysregulation-adding-vitamin-d-deficiency-to-the-allostatic-load-index
#8
Eynav Elgavish Accortt, James Mirocha, Christine Dunkel Schetter, Calvin J Hobel
Background Allostatic load (AL) is an index of multi-system physiological "wear-and-tear," operationalizing emergent chronic disease risk and predicting morbidity and mortality. AL has been proposed as an organizing framework for studying pregnancy outcomes and additional AL biomarkers for the study of maternal health would be valuable. Objectives To test whether adverse perinatal outcomes are associated with postpartum AL and if including vitamin D deficiency (serum 25(OH)D < 20 ng/ml) as an additional marker of postpartum AL increases the association...
January 24, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28117143/review-placental-derived-biomarkers-of-pregnancy-disorders
#9
REVIEW
James S M Cuffe, Olivia Holland, Carlos Salomon, Gregory E Rice, Anthony V Perkins
Pregnancy is one of the greatest physiological challenges that a women can experience. The physiological adaptations that accompany pregnancy may increase the risk of developing a number of disorders that can lead to both acute and chronic physiological outcomes. In addition, fetal development may be impaired and, if the fetus survives, the child may be at an increased risk of disease throughout life. Pregnancy disorders are poorly predicted by traditional risk factors and maternal history alone. The identification of biomarkers that can predict incidence and severity of disease would allow for improved and targeted prophylactic therapies to prevent adverse maternal and fetal outcomes...
January 16, 2017: Placenta
https://www.readbyqxmd.com/read/28110600/an-examination-of-the-factors-affecting-intestinal-wall-integrity-in-newborns-at-birth
#10
Soyhan Bagci, Daniel Mensinga, David Katzer, Waltraut M Merz, Heiko Reutter, Andreas Müller
BACKGROUND: An understanding of the factors that influence intestinal wall integrity during the transition from fetal to neonatal life is important to elucidate and minimize potential contributions to the development of intestinal pathologies in vulnerable newborns. OBJECTIVE: To assess the factors affecting intestinal wall integrity of late preterm and term newborns at birth. METHODS: The concentrations of serum intestinal fatty acid binding protein (I-FABP) as biomarker of intestinal wall injury, superoxide dismutase (SOD), and glutathione peroxidase (Gpx) as parameters of oxidative stress, and blood gas analyses were measured in the arterial cord blood of 80 newborns, delivered by spontaneous vaginal delivery (labour group) or elective caesarean delivery (non-labour group)...
January 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28099428/biomarkers-of-adiposity-are-elevated-in-preterm-very-low-birth-weight-infants-at-1-2-and-3-years-of-age
#11
Andrea F Duncan, Joshua A Frankfurt, Roy J Heyne, Charles R Rosenfeld
BACKGROUND: Preterm, very-low-birth-weight (PT-VLBW) neonates are at-risk for metabolic syndrome later in life. At 1-3yrs, they exhibit excessive weight-for-length z-scores (Wt-LZ) and elevated systolic blood pressures (SBP). Serum adipokines are biomarkers of adiposity, but expression in PT-VLBW infants is unclear. We examined the correlation between serum adipokine levels, anthropometric measures and SBP in PT-VLBW neonates at follow-up. METHODS: This was a cross-sectional cohort study of PT-VLBW infants at 1, 2 and 3yrs of age (40/cohort)...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28073296/the-microbiome-and-complement-activation
#12
Alexis B Dunn, Anne L Dunlop, Carol J Hogue, Andrew Miller, Elizabeth J Corwin
Preterm birth (PTB, <37 completed weeks' gestation) is one of the leading obstetrical problems in the United States, affecting approximately one of every nine births. Even more concerning are the persistent racial disparities in PTB, with particularly high rates among African Americans. There are several recognized pathophysiologic pathways to PTB, including infection and/or exaggerated systemic or local inflammation. Intrauterine infection is a causal factor linked to PTB thought to result most commonly from inflammatory processes triggered by microbial invasion of bacteria ascending from the vaginal microbiome...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28068849/maternal-serum-calponin-1-level-as-a-biomarker-for-the-short-term-prediction-of-preterm-birth-in-women-with-threatened-preterm-labor
#13
Orkun Cetin, Erbil Karaman, Baris Boza, Numan Cim, Hanım Guler Sahin
PURPOSE: To assess the utility of maternal serum calponin 1 level in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor. MATERIALS AND METHODS: Eligible women who presented at 24-34 weeks of gestation with threatened preterm labor underwent sampling for serum calponin 1 level and cervical length measurement. They were followed-up until delivery prospectively and the perinatal outcomes of the patients were recorded...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28067049/amniotic-fluid-and-maternal-serum-metabolic-signatures-in-the-second-trimester-associated-with-preterm-delivery
#14
Christina Virgiliou, Helen G Gika, Michael Witting, Anna A Bletsou, Apostolos Athanasiadis, Menelaos Zafrakas, Nikolaos S Thomaidis, Nikolaos Raikos, Georgios Makrydimas, Georgios A Theodoridis
Preterm delivery (PTD) represents a major health problem that occurs in 1 in 10 births. The hypothesis of the present study was that the metabolic profile of different biological fluids, obtained from pregnant women during the second trimester of gestation, could allow useful correlations with pregnancy outcome. Holistic and targeted metabolomics approaches were applied for the complementary assessment of the metabolic content of prospectively collected amniotic fluid (AF) and paired maternal blood serum samples from 35 women who delivered preterm (between 29 weeks + 0 days and 36 weeks +5 days gestation) and 35 women delivered at term...
January 23, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28045978/cord-blood-acute-phase-reactants-predict-early-onset-neonatal-sepsis-in-preterm-infants
#15
Leena B Mithal, Hannah L Palac, Ram Yogev, Linda M Ernst, Karen K Mestan
BACKGROUND: Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation of acute phase reactant (APR) biomarkers in umbilical cord blood at birth may improve EOS detection in preterm infants with intrauterine infection. METHODS: In this nested case-control study, infants (29.7 weeks gestation, IQR: 27.7-32...
2017: PloS One
https://www.readbyqxmd.com/read/28043842/repeated-measures-of-inflammation-and-oxidative-stress-biomarkers-in-preeclamptic-and-normotensive-pregnancies
#16
Kelly K Ferguson, John D Meeker, Thomas F McElrath, Bhramar Mukherjee, David E Cantonwine
BACKGROUND: Preeclampsia is a prevalent and enigmatic disease, in part characterized by poor remodeling of the spiral arteries. However, preeclampsia does not always clinically present, even when remodeling has failed to occur. Hypotheses surrounding the "second hit" that is necessary for the clinical presentation of the disease focus on maternal inflammation and oxidative stress. Yet, the studies to date that have investigated these factors have used cross-sectional study designs or small study populations...
December 30, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28026756/longitudinal-analysis-of-pre-term-neonatal-cerebral-ventricles-from-3d-ultrasound-images-using-spatial-temporal-deformable-registration
#17
Wu Qiu, Yimin Chen, Jessica Kishimoto, Sandrine Ribaupierre, Bernard Chiu, Aaron Fenster, Bijoy Menon, Jing Yuan
Preterm neonates with a very low birth weight of less than 1,500 grams are at increased risk for developing intraventricular hemorrhage (IVH), which is a major cause of brain injury in preterm neonates. Quantitative measurements of ventricular dilatation or shrinkage play an important role in monitoring patients and evaluating treatment options. 3D ultrasound (US) has been developed to monitor ventricle volume as a biomarker for ventricular changes. However, ventricle volume as a global indicator does not allow for precise analysis of local ventricular changes, which could be linked to specific neurological problems often seen in the patient population later in life...
December 22, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27925621/presepsin-for-the-detection-of-early-onset-sepsis-in-preterm-newborns
#18
Paolo Montaldo, Roberto Rosso, Alfredo Santantonio, Giovanni Chello, Paolo Giliberti
BACKGROUND: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP). STUDY DESIGN: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27881405/effectiveness-of-individualized-lung-recruitment-strategies-at-birth-an-experimental-study-in-preterm-lambs
#19
David G Tingay, Anushi Rajapaksa, Emanuela Zannin, Prue M Pereira-Fantini, Raffaele L Dellaca, Elizabeth J Perkins, Cornelis E E Zonneveld, Andy Adler, Don Black, Inéz Frerichs, Anna Lavizzari, Magdy Sourial, Bartłomiej Grychtol, Fabio Mosca, Peter G Davis
Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung while aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume response and a dynamic tidal positive end-expiratory pressure (PEEP) (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment maneuver (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration, and lung injury in 127 ± 1 day preterm lambs...
January 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27871275/rationale-and-design-of-support-a-multi-centre-randomised-controlled-trial-to-compare-three-treatments-cervical-cerclage-cervical-pessary-and-vaginal-progesterone-for-the-prevention-of-preterm-birth-in-women-who-develop-a-short-cervix
#20
Natasha L Hezelgrave, Helena A Watson, Alexandra Ridout, Falak Diab, Paul T Seed, Evonne Chin-Smith, Rachel M Tribe, Andrew H Shennan
BACKGROUND: Clinically, once a woman has been identified as being at risk of spontaneous preterm birth (sPTB) due to a short cervical length, a decision regarding prophylactic treatment must be made. Three interventions have the potential to improve outcomes: cervical cerclage (stitch), vaginal progesterone and cervical pessary. Each has been shown to have similar benefit in reduction of sPTB, but there have been no randomised control trials (RCTs) to compare them. METHODS: This open label multi-centre UK RCT trial, will evaluate whether the three interventions are equally efficacious to prevent premature birth in women who develop a short cervix (<25 mm on transvaginal ultrasound)...
November 21, 2016: BMC Pregnancy and Childbirth
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