keyword
https://read.qxmd.com/read/38521041/iron-nuclearity-in-mineral-fibres-unravelling-the-catalytic-activity-for-predictive-modelling-of-toxicity
#21
JOURNAL ARTICLE
Alessandro F Gualtieri, Marina Cocchi, Francesco Muniz-Miranda, Alfonso Pedone, Elena Castellini, Lorenzo Strani
Chronic inflammation induced in vivo by mineral fibres, such as asbestos, is sustained by the cyclic formation of cytotoxic/genotoxic oxidant species that are catalysed by iron. High catalytic activity is observed when iron atoms are isolated in the crystal lattice (nuclearity=1), whereas the catalytic activity is expected to be reduced or null when iron forms clusters of higher nuclearity. This study presents a novel approach for systematically measuring iron nuclearity across a large range of iron-containing standards and mineral fibres of social and economic importance, and for quantitatively assessing the relation between nuclearity and toxicity...
March 11, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38519402/genetic-and-biologic-risk-factors-associated-with-hernia-formation-a-review
#22
REVIEW
Chris Amro, Ellen F Niu, Ellie Deianni, Laurie Smith, Maylene Qiu, Jared Torkington, Robyn B Broach, Lillias H Maguire, Scott M Damrauer, Kamal Itani, John P Fischer
BACKGROUND: This systematic review aims to identify genetic and biologic markers associated with abdominal hernia formation. METHODS: Following PRIMSA-guidelines, we searched PubMed, MEDLINE, Embase, Scopus, and COCHRANE databases. RESULTS: Of 5946 studies, 65 were selected, excluding parastomal hernias due to insufficient data. For inguinal hernias, five studies unveiled 92 susceptible loci across 66 genes, predominantly linked to immune responses...
February 27, 2024: American Journal of Surgery
https://read.qxmd.com/read/38517029/sorghum-phytonutrients-and-their-health-benefits-a-systematic-review-from-cell-to-clinical-trials
#23
REVIEW
Lívia de Lacerda de Oliveira, Lúcio Flávio de Alencar Figueiredo
Sorghum is key for global food security due to its genetic variability, resilience, and rich phytonutrient content, which are linked to numerous health benefits. A systematic review assessed the health effects of sorghum by analyzing cell (n = 22), animal (n = 20), and human (n = 7) studies across antioxidant, anti-inflammatory, obesity, cancer, cardiovascular, and diabetes outcomes. This review, involving 42 papers and 177 researchers from 12 countries, collected data from sorghum accessions (acc) and significant effects...
March 22, 2024: Journal of Food Science
https://read.qxmd.com/read/38514290/efficacy-and-safety-of-lotilaner-ophthalmic-solution-0-25-for-the-treatment-of-demodex-blepharitis-a-meta-analysis-of-randomized-controlled-trials
#24
REVIEW
Syed Muhammad Muneeb Akhtar, Areeba Fareed, Muhammad Sohaib Asghar, Munazza Mumtaz, Sehajpreet Kaur
PURPOSE: Demodex blepharitis, often overlooked in ocular surface disease, involves Demodex mites, prevalent ectoparasites on human skin. Current treatments may not effectively eliminate these mites, prompting a need for targeted therapies. Lotilaner, an antiparasitic agent, shows promise. This systematic review and meta-analysis assesses 0.25% lotilaner ophthalmic solution's efficacy in reducing Demodex mite populations and its impact on ocular surface inflammation in Demodex blepharitis patients...
March 20, 2024: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://read.qxmd.com/read/38512961/titanium-induces-pro-inflammatory-and-tissue-destructive-responses-in-primary-human-macrophages
#25
JOURNAL ARTICLE
Alexandru Gudima, David Hesselbarth, Guanhao Li, Vladimir Riabov, Julia Michel, Quan Liu, Christina Schmuttermaier, Zhen Jiao, Carsten Sticht, Ahmed Jawhar, Udo Obertacke, Harald Klüter, Nihal Engin Vrana, Julia Kzhyshkowska
Implants and medical devices are efficient and practical therapeutic solutions for a multitude of pathologies. Titanium and titanium alloys are used in orthopedics, dentistry, and cardiology. Despite very good mechanical properties, and corrosion resistance titanium implants can fail due to inflammatory or tissue-degradation related complications. Macrophages are major immune cells that control acceptance of failure of the implant. In this study, for the first time, we have performed a systematic analysis of the response of differentially activated human macrophages (M(Control), M(IFNγ) and M(IL-4)) to the polished and porous titanium surfaces in order to identify the detrimental effect of titanium leading to the tissue destruction and chronic inflammation...
March 21, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38512383/a-comparison-of-doxycycline-and-conventional-treatments-of-refractory-chronic-rhinosinusitis-with-nasal-polyps-a-systematic-review-and-meta-analysis
#26
REVIEW
Do Hyun Kim, Hyesoo Shin, Gulnaz Stybayeva, Se Hwan Hwang
PURPOSE: To compare the effects of doxycycline (DOX) and conventional management in patients with refractory chronic rhinosinusitis and nasal polyps (CRSwNP). METHODS: Six databases were searched to September 2023. We retrieved studies that compared improvements in refractory chronic sinusitis-related symptoms between DOX-treated and control groups. RESULTS: DOX significantly reduced the Lund-Kennedy (LK) score [- 0.3670 (range - 0...
March 21, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38511137/platelet-lymphocyte-ratio-predicts-chemotherapy-response-and-prognosis-in-patients-with-gastric-cancer-undergoing-radical-resection
#27
JOURNAL ARTICLE
Qingnuo Zeng, Shilong Wang, Zilong Bai, Yuanhua Nie, Longwen Xu, Dongmin Chang
BACKGROUND: Amounting literatures have reported the significance of systemic inflammatory markers for evaluating tumor prognosis. But few studies have systematically compared their superiority and their impact on adjuvant chemotherapy. AIMS: We aimed to investigate the ability of inflammatory markers to predict the efficacy of chemotherapy in GC patients undergoing radical therapy and to identify an effective methodology based on the study's findings that would enable clinicians to differentiate between chemotherapy-responsive populations...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38508699/association-between-inflammation-and-post-intensive-care-syndrome-a-systematic-review
#28
REVIEW
C Docherty, C Page, J Wilson, P Ross, K Garrity, T Quasim, M Shaw, J McPeake
Post-intensive care syndrome describes the physical, cognitive and emotional symptoms which persist following critical illness. At present there is limited understanding of the pathological mechanisms contributing to the development of post-intensive care syndrome. The aim of this systematic review was to synthesise current evidence exploring the association between inflammation and features of post-intensive care syndrome in survivors of critical illness. Relevant databases were systematically searched for studies of human participants exposed to critical illness...
March 20, 2024: Anaesthesia
https://read.qxmd.com/read/38507067/identification-of-a-novel-adcc-related-gene-signature-for-predicting-the-prognosis-and-therapy-response-in-lung-adenocarcinoma
#29
JOURNAL ARTICLE
Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu, Fancai Lai
BACKGROUND: Previous studies have largely neglected the role of ADCC in LUAD, and no study has systematically compiled ADCC-associated genes to create prognostic signatures. METHODS: In this study, 1564 LUAD patients, 2057 NSCLC patients, and more than 5000 patients with various cancer types from diverse cohorts were included. R package ConsensusClusterPlus was utilized to classify patients into different subtypes. A number of machine-learning algorithms were used to construct the ADCCRS...
March 20, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38507018/phytochemistry-of-medicinal-herbs-belongs-to-asclepiadaceae-family-for-therapeutic-applications-a-critical-review
#30
REVIEW
Navytchmathra Gammatantrawet, Chuyên Thuận Nguyễn, Chanthana Susawaengsup, Aizi Nor Mazila Ramli, Krittiya Tongkoom, Tawan Chatsungnoen, Rapeephun Dangtungee, Prakash Bhuyar
The world of pharmaceutical research has been increasingly turning its gaze toward the treasure trove of natural products in search of novel drugs and therapeutic agents. Amidst the vast array of medicinal plants that dot our planet, the Asclepiadaceae family unexplored species have piqued the interest of researchers. Both medicinal plants are indigenous to specific regions and have been integral to traditional medicine systems for centuries. This systematic review aims to provide a comprehensive summary of the current knowledge regarding the phytochemical profile of these plants and their potential implications in the pharmaceutical industry...
March 20, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38506440/high-flow-nasal-cannula-therapy-for-infants-with-bronchiolitis
#31
REVIEW
Michael Armarego, Hannah Forde, Karen Wills, Sean A Beggs
BACKGROUND: Bronchiolitis is a common lower respiratory tract illness, usually of viral aetiology, affecting infants younger than 24 months of age and is the most common cause of hospitalisation of infants. It causes airway inflammation, mucus production and mucous plugging, resulting in airway obstruction. Effective pharmacotherapy is lacking and bronchiolitis is a major cause of morbidity and mortality. Conventional treatment consists of supportive therapy in the form of fluids, supplemental oxygen, and respiratory support...
March 20, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38506423/diagnostic-value-of-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio-to-predict-recurrent-pregnancy-loss-and-abortion-a-systematic-review-and-meta-analysis
#32
REVIEW
Sedigheh Hantoushzadeh, Omid Kohandel Gargar, Kyana Jafarabady, Mohammad Moein Rezaei, Fatemeh Asadi, Nasim Eshraghi, Zahra Panahi, Saeedeh Shirdel, Masoumeh Mirzamoradi, Marjan Ghaemi
OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in women with a history of abortion (missed and threatened) and recurrent pregnancy loss (RPL) in comparison with healthy pregnancies. METHODS: Electronic databases including MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library were searched for NLR and PLR in women who experienced early pregnancy loss up to January 1, 2023 with a combination of proper keywords...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38506343/prophylactic-corticosteroids-for-cardiopulmonary-bypass-in-adult-cardiac-surgery
#33
REVIEW
Riccardo Giuseppe Abbasciano, Guido Maria Olivieri, Rachel Chubsey, Francesca Gatta, Nathan Tyson, Keertana Easwarakumar, Daniel P Fudulu, Roberto Marsico, Markus Kofler, Ghazi Elshafie, Florence Lai, Mahmoud Loubani, Simon Kendall, Mustafa Zakkar, Gavin J Murphy
BACKGROUND: Cardiac surgery triggers a strong inflammatory reaction, which carries significant clinical consequences. Corticosteroids have been suggested as a potential perioperative strategy to reduce inflammation and help prevent postoperative complications. However, the safety and effectiveness of perioperative corticosteroid use in adult cardiac surgery is uncertain. This is an update of the 2011 review with 18 studies added. OBJECTIVES: Primary objective: to estimate the effects of prophylactic corticosteroid use in adults undergoing cardiac surgery with cardiopulmonary bypass on the: - co-primary endpoints of mortality, myocardial complications, and pulmonary complications; and - secondary outcomes including atrial fibrillation, infection, organ injury, known complications of steroid therapy, prolonged mechanical ventilation, prolonged postoperative stay, and cost-effectiveness...
March 20, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38504306/unraveling-the-therapeutic-efficacy-of-resveratrol-in-alzheimer-s-disease-an-umbrella-review-of-systematic-evidence
#34
REVIEW
Ali Azargoonjahromi, Fatemeh Abutalebian
CONTEXT: Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential in treating Alzheimer's disease (AD). RV has shown promise in inhibiting the formation of beta-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs), protecting against neuronal damage and oxidative stress, reducing inflammation, promoting neuroprotection, and improving the function of the blood-brain barrier (BBB). However, conflicting results have been reported, necessitating a comprehensive umbrella review of systematic reviews to provide an unbiased conclusion on the therapeutic effectiveness of RV in AD...
March 19, 2024: Nutrition & Metabolism
https://read.qxmd.com/read/38503629/efficacy-of-nemiralisib-in-chronic-obstructive-pulmonary-disease-a-systematic-review
#35
REVIEW
Hongkuan Yang, Shuifeng He, Linbao Liang, Junjie Pan
PURPOSE: Chronic obstructive pulmonary disease (COPD) is a major public health concern. Exacerbation of COPD leads to poor health and frequent episodes of increased systemic and airway inflammation. Immunomodulatory drugs have garnered extensive attention because they may reduce the rate of COPD exacerbation. This review aimed to evaluate the efficacy and safety of nemiralisib in COPD patients. METHODS: Medical databases, including the Cochrane Library, EMBASE, and PubMed, were queried from inception to June 2023 to identify randomized controlled trials (RCTs) on the efficacy of nemiralisib in COPD patients...
March 18, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38503153/therapeutic-effects-of-epigallocatechin-3-gallate-for-inflammatory-bowel-disease-a-preclinical-meta-analysis
#36
JOURNAL ARTICLE
Feng Wei, Delin Li, Xiaodong Chen, Yubing Li, Yuting Zeng, Yilin Cai, Youtao Zeng, Yu Chen, Xiao Ma, Jinhao Zeng
BACKGROUND: Epigallocatechin-3-gallate (EGCG), the primary active compound in green tea, is recognized for its significant anti-inflammatory properties and potential pharmacological effects on inflammatory bowel disease (IBD). However, comprehensive preclinical evidence supporting the use of EGCG in treating IBD is currently insufficient. PURPOSE: To evaluate the efficacy of EGCG in animal models of IBD and explore potential underlying mechanisms, serving as a groundwork for future clinical investigations...
February 2, 2024: Phytomedicine
https://read.qxmd.com/read/38502791/multifaceted-effects-of-subchronic-exposure-to-chlorfenapyr-in-mice-implications-from-serum-metabolomics-hepatic-oxidative-stress-and-intestinal-homeostasis
#37
JOURNAL ARTICLE
Yabing Xiong, Xiaoran Ma, Bingying He, Jianwen Zhi, Xueke Liu, Peng Wang, Zhiqiang Zhou, Donghui Liu
As chlorfenapyr is a commonly used insecticide in agriculture, the health risks of subchronic exposure to chlorfenapyr remained unclear. This study aimed to extensively probe the health risks from subchronic exposure to chlorfenapyr at the NOAEL and 10-fold NOAEL dose in mice. Through pathological and biochemical examinations, the body metabolism, hepatic toxicity, and intestinal homeostasis were systematically assessed. After 12 weeks, a 10-fold NOAEL dose of chlorfenapyr resulted in weight reduction, increased daily food intake, and blood lipid abnormalities...
March 19, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38501534/covid-19-in-patients-with-down-syndrome-a-systematic-review
#38
REVIEW
Praveen N K Pitchan Velammal, Suryakumar Balasubramanian, Fathima Shehnaz Ayoobkhan, Gautham V K Mohan, Pearl Aggarwal, Ali A Rabaan, Syed A Khan, Farah Yasmin, Thoyaja Koritala, Salim R Surani
INTRODUCTION: Down syndrome (DS) is associated with multiple comorbid conditions and chronic immune dysfunction. Persons with DS who contract COVID-19 are at high risk for complications and have a poor prognosis. We aimed to study the clinical symptoms, laboratory and biochemical profiles, radiologic findings, treatment, and outcomes of patients with DS and COVID-19. METHOD: We systematically searched PubMed, MEDLINE, Web of Science, Scopus, and the Cochrane Library using the keywords COVID-19 or coronavirus or SARS-CoV-2 and DS or trisomy 21...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38500443/prevalence-of-at-risk-mash-metald-and-alcohol-associated-steatotic-liver-disease-in-the-general-population
#39
JOURNAL ARTICLE
Carolin V Schneider, Kai Markus Schneider, Anastasia Raptis, Helen Huang, Christian Trautwein, Rohit Loomba
BACKGROUND: The prevalence of at-risk metabolic dysfunction-associated steatohepatitis (at-risk MASH) has not been systematically assessed. AIM: To delineate the prevalence of at-risk MASH in a large population-based cohort. METHODS: We conducted a cross-sectional analysis of 40,189 patients in the UK Biobank who underwent liver MRI. Hepatic steatosis was determined by proton density fat fraction (PDFF) ≥5%. Based on AASLD criteria, participants were classified as alcohol-associated steatotic liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), combined metabolic alcoholic liver disease (MetALD) and at-risk MASH...
March 19, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38499791/effects-of-low-carbohydrate-diets-with-and-without-caloric-restriction-on-inflammatory-markers-in-adults-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#40
REVIEW
Fatemeh Kazeminasab, Maryam Miraghajani, Mousa Khalafi, Mohammad Hossein Sakhaei, Sara K Rosenkranz, Heitor O Santos
Low-carbohydrate diets (LCDs) have gained interest due to their favorable effects on health outcomes, such as inflammation. However, further research is needed to ascertain the overall effects of LCDs on inflammatory parameters, but at the same time considering weight loss and calorie intake. Thus, a systematic review and meta-analysis of randomized clinical trials was performed to investigate the effects of LCDs compared with low-fat diets (LFDs), with and without caloric restriction, on inflammatory markers in adults...
March 18, 2024: European Journal of Clinical Nutrition
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