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https://www.readbyqxmd.com/read/29329905/consensus-recommendations-for-evaluation-interpretation-and%C3%A2-utilization-of-computed-tomography-and-magnetic-resonance-enterography-in-patients-with-small-bowel-crohn-s%C3%A2-disease
#1
David H Bruining, Ellen M Zimmermann, Edward V Loftus, William J Sandborn, Cary G Sauer, Scott A Strong
Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn's disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will improve the utility of these imaging techniques to guide treatment options, as well as assess for treatment response and complications. Representatives from the Society of Abdominal Radiology Crohn's Disease-Focused Panel, the Society of Pediatric Radiology, the American Gastroenterological Association, and other experts, systematically evaluated evidence for imaging findings associated with small bowel Crohn's disease enteric inflammation and established recommendations for the evaluation, interpretation, and use of computed tomography and magnetic resonance enterography in small bowel Crohn's disease...
December 30, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29324654/zinc-status-and-autoimmunity-a-systematic-review-and-meta-analysis
#2
REVIEW
Alessandro Sanna, Davide Firinu, Patrizia Zavattari, Paolo Valera
Zinc is an essential trace element for living organisms and their biological processes. Zinc plays a key role in more than 300 enzymes and it is involved in cell communication, proliferation, differentiation and survival. Zinc plays also a role in regulating the immune system with implications in pathologies where zinc deficiency and inflammation are observed. In order to examine the experimental evidence reported in the literature regarding zinc levels in the body of patients with autoimmune disorders compared to control individuals, a systematic review and meta-analysis were performed...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29323338/ulinastatin-attenuates-lps-induced-inflammation-in-mouse-macrophage-raw264-7-cells-by-inhibiting-the-jnk-nf-%C3%AE%C2%BAb-signaling-pathway-and-activating-the-pi3k-akt-nrf2-pathway
#3
Si-Tong Li, Qi Dai, Shu-Xian Zhang, Ya-Jun Liu, Qiu-Qiong Yu, Fei Tan, Shu-Hong Lu, Quan Wang, Jian-Wen Chen, He-Qing Huang, Pei-Qing Liu, Min Li
Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from human urine with strong anti-inflammatory and cytoprotective actions, which is widely used for the treatment of various diseases, such as pancreatitis and sepsis. Although the therapeutic effects of UTI are reported to be associated with a variety of mechanisms, the signaling pathways mediating the anti-inflammatory action of UTI remain to be elucidated. In the present study we carried out a systematic study on the anti-inflammatory and anti-oxidative mechanisms of UTI and their relationships in LPS-treated RAW264...
January 11, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29322929/ontology-based-systematic-representation-and-analysis-of-traditional-chinese-drugs-against-rheumatism
#4
Qingping Liu, Jiahao Wang, Yan Zhu, Yongqun He
BACKGROUND: Rheumatism represents any disease condition marked with inflammation and pain in the joints, muscles, or connective tissues. Many traditional Chinese drugs have been used for a long time to treat rheumatism. However, a comprehensive information source for these drugs is still missing, and their anti-rheumatism mechanisms remain unclear. An ontology for anti-rheumatism traditional Chinese drugs would strongly support the representation, analysis, and understanding of these drugs...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29319414/consensus-recommendations-for-evaluation-interpretation-and-utilization-of-computed-tomography-and-magnetic-resonance-enterography-in-patients-with-small-bowel-crohn-s-disease
#5
David H Bruining, Ellen M Zimmermann, Edward V Loftus, William J Sandborn, Cary G Sauer, Scott A Strong
Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn's disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will improve the utility of these imaging techniques to guide treatment options, as well as assess for treatment response and complications. Representatives from the Society of Abdominal Radiology Crohn's Disease-Focused Panel, the Society of Pediatric Radiology, the American Gastroenterological Association, and other experts, systematically evaluated evidence for imaging findings associated with small bowel Crohn's disease enteric inflammation and established recommendations for the evaluation, interpretation, and use of computed tomography and magnetic resonance enterography in small bowel Crohn's disease...
January 10, 2018: Radiology
https://www.readbyqxmd.com/read/29318964/potential-role-of-inflammation-in-associations-between-particulate-matter-and-heart-failure
#6
Xiaotong Ji, Yingying Zhang, Guangke Li, Nan Sang
Recently, numerous studies have found that particulate matter (PM) exposure is correlated with increased hospitalization and mortality from heart failure (HF). In addition to problems with circulation, HF patients often display high expression of cytokines in the failing heart. Thus, as a recurring heart problem, HF is thought to be a disorder characterized in part by the inflammatory response. In this review, we intend to discuss the relationship between PM exposure and HF that is based on inflammatory mechanism and to provide a comprehensive, updated evaluation of the related studies...
January 10, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29314593/in-vivo-immuno-reactivity-analysis-of-the-porous-3d-cs-sio2-and-cs-sio2-ha-hybrids
#7
Mengxia Guo, Yifan Dong, Jiangwei Xiao, Ruicai Gu, Maochao Ding, Tao Huang, Junhua Li, Naru Zhao, Hua Liao
Inorganic/organic hybrid silica-chitosan scaffolds have promising potential for bone defect repair, due to the controllable mechanical properties, degradation behavior and scaffold morphology. However, the precise in vivo immuno-reactivity of silica-chitosan hybrids with various compositions is still poorly defined. In this study, we fabricated the 3D interconnected porous chitosan-silica (CS/SiO2 ) and chitosan-silica-hydroxyapatite (CS/SiO2 /HA) hybrids, through sol-gel process and 3D plotting skill, followed by the naturally or freeze drying separately...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29310893/effect-of-fat-composition-in-enteral-nutrition-for-crohn-s-disease-in-adults-a-systematic-review
#8
REVIEW
Sarah M Ajabnoor, Alastair Forbes
BACKGROUND & AIMS: The role of enteral nutrition (EN) fat composition in regulating inflammation in Crohn's disease (CD) is not clear. There is, moreover, insufficient evidence to guide the choice of EN in CD with any confidence. We have reanalysed the findings of previous studies in a systematic review focussing on the relationship between EN fat content and remission rates (RR). METHODS: A systematic search with no language restriction was undertaken in Medline and Embase databases supplemented by a manual search in the reference lists of identified studies...
December 28, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29301530/understanding-amd-by-analogy-systematic-review-of-lipid-related-common-pathogenic-mechanisms-in-amd-ad-as-and-gn
#9
REVIEW
Qinyuan Xu, Sijia Cao, Sanjeeva Rajapakse, Joanne A Matsubara
RATIONALE: Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly. Due to its complex etiology, current treatments have been insufficient. Previous studies reveal three systems closely involved in AMD pathogenesis: lipid metabolism, oxidation and inflammation. These systems are also involved in Alzheimer's disease, atherosclerosis and glomerulonephritis. Understanding commonalities of these four diseases may provide insight into AMD etiology...
January 4, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29299877/cocoa-flavanol-supplementation-and-exercise-a-systematic-review
#10
REVIEW
Lieselot Decroix, Danusa Dias Soares, Romain Meeusen, Elsa Heyman, Cajsa Tonoli
BACKGROUND: Cocoa flavanols (CFs) have antioxidant and anti-inflammatory capacities and can improve vascular function. It has recently been suggested that CF intake may improve exercise performance and recovery. This systematic review aimed to evaluate the literature on the effects of CF intake on exercise performance and recovery and exercise-induced changes in vascular function, cognitive function, oxidative stress, inflammation, and metabolic parameters. METHODS: Two electronic databases (Pubmed and Web of Science) were searched for studies examining the combination of CF intake and exercise in humans (up to 28 March 2017)...
January 3, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29290784/systemic-inflammation-biomarkers-predict-survival-in-patients-of-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-ablative-radiotherapy-a-single-center-experience
#11
Hui Luo, Hong Ge, Yingying Cui, Jiangong Zhang, Ruitai Fan, Anping Zheng, Xiaoli Zheng, Yanan Sun
Background: Increasing evidence indicates a relationship between systemic inflammation and survival following treatment in various tumors. However, the correlation of systematic inflammation with survival after stereotactic ablative radiotherapy (SABR) in early stage non-small cell lung cancer (NSCLC) has not been well established. Patients and methods: We retrospectively analyzed patients with newly diagnosed early stage NSCLC treated with SABR in a single institution from 2011 to 2015. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte- monocyte ratio (LMR) were calculated as systemic inflammation biomarkers...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29289704/contribution-of-photodynamic-therapy-in-wound-healing-a-systematic-review
#12
REVIEW
Vanessa Nesi-Reis, Daniele Stéfanie Sara Lopes Lera-Nonose, Jully Oyama, Marielle Priscila Paula Silva-Lalucci, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
OBJECTIVE: We researched articles that used photodynamic therapy (PDT) in skin wound healing in humans. METHODS: The systematic review was conducted throughout scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. RESULTS: The main types of wound described in selected articles in this review were chronic ulcer, non-melanoma skin cancer...
December 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29288248/effect-of-conjugated-linoleic-acid-on-blood-inflammatory-markers-a-systematic-review-and-meta-analysis-on-randomized-controlled-trials
#13
REVIEW
Fahimeh Haghighatdoost, B Fatemeh Nobakht M Gh
BACKGROUND/OBJECTIVES: Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid with attractive biological activities. Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models. However, the effects of CLA treatment on the inflammatory markers in humans are controversial. Therefore, the objective of this study was to perform a systematic review and meta-analysis on controlled clinical trials (RCT) assessing the effects of CLA supplementation on the circulating inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)...
December 29, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29287458/structures-bioactivities-and-future-prospective-of-polysaccharides-from-morus-alba-white-mulberry-a-review
#14
REVIEW
Xirui He, Jiacheng Fang, Yinlan Ruan, Xiaoxiao Wang, Yin Sun, Ni Wu, Zefeng Zhao, Yu Chang, Ning Ning, Hao Guo, Linhong Huang
Morus alba L. (family Moreaceae), also known as white mulberry, is distinguished as a source of highly promising traditional medicines (including Mori Folium, Mori Fructus, Mori Ramulus and Mori Cortex) and also functional foods. Over the past two decades, the vast majority of the studies with regard to the isolation and bioactivities of M. alba polysaccharides have mainly focused on its leaves and fruits, which are both medicinal and edible. The tender M. alba leaf is edible and can be used to make tea, the mature M...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29285775/systemic-immune-inflammation-index-predicts-the-combined-clinical-outcome-after-sequential-therapy-with-abiraterone-and-docetaxel-for-metastatic-castration-resistant-prostate-cancer-patients
#15
Liancheng Fan, Rui Wang, Chenfei Chi, Wen Cai, Yong Zhang, Hongyang Qian, Xiaoguang Shao, Yanqing Wang, Fan Xu, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Lixin Zhou, Baijun Dong, Wei Xue
OBJECTIVE: To compare the antitumor effect of abiraterone (AA) followed by docetaxel-prednisone (DP) or vice versa in metastatic castration-resistant prostate cancer (mCRPC) patients, and explored factors that might predict combined PSA-PFS, combined rPFS and OS. PATIENTS AND METHODS: We retrospectively analyzed mCRPC patients treated with sequential therapy using DP followed by AA or vice versa. Patients who had received enzalutamide or cabazitaxel were excluded...
December 29, 2017: Prostate
https://www.readbyqxmd.com/read/29284102/does-finishing-and-polishing-of-restorative-materials-affect-bacterial-adhesion-and-biofilm-formation-a-systematic-review
#16
Dam Dutra, Gkr Pereira, K Z Kantorski, L F Valandro, F B Zanatta
Biofilm (bacterial plaque) accumulation on the surface of restorative materials favors the occurrence of secondary caries and periodontal inflammation. Surface characteristics of restorations can be modified by finishing and/or polishing procedures and may affect bacterial adhesion. The aim of this systematic review was to characterize how finishing and polishing methods affect the surface properties of different restorative materials with regard to bacterial adhesion and biofilm formation. Searches were carried out in MEDLINE-PubMed, EMBASE, Cochrane-CENTRAL, and LILACS databases...
January 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29276788/a-role-for-soluble-il-6-receptor-in-osteoarthritis
#17
Graham Akeson, Charles J Malemud
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA). The mechanism of action of IL-6 was shown to involve its capacity to interact with a membrane-bound IL-6 receptor (mIL-6Rα), also known as the "classical" IL-6 pathway, or through its interaction with a soluble IL-6 receptor (sIL-6R) termed the "trans-signaling" pathway. Activation of downstream signaling is transduced via these IL-6 receptors and principally involves the Janus Kinase/Signal Transduction and Activators of Transcription (JAK/STAT) signaling pathway that is further regulated by glycoprotein-130 (gp130) interacting with the IL-6/mIL-6R complex...
2017: Journal of Functional Morphology and Kinesiology
https://www.readbyqxmd.com/read/29276488/prebiotic-effect-of-fructooligosaccharides-from-morinda-officinalis-on-alzheimer-s-disease-in-rodent-models-by-targeting-the-microbiota-gut-brain-axis
#18
Diling Chen, Xin Yang, Jian Yang, Guoxiao Lai, Tianqiao Yong, Xiaocui Tang, Ou Shuai, Gailian Zhou, Yizhen Xie, Qingping Wu
Gut microbiota influences the central nervous system disorders such as Alzheimer's disease (AD). The prebiotics and probiotics can improve the host cognition. A previous study demonstrated that fructooligosaccharides from Morinda officinalis (OMO) exert effective memory improvements in AD-like animals, thereby considered as potential prebiotics; however, the underlying mechanism still remains enigma. Thus, the present study investigated whether OMO is effective in alleviating AD by targeting the microbiota-gut-brain axis...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29260632/biologic-and-epidemiologic-evidence-assessing-if-statins-prevent-prostate-cancer
#19
David E Dawe, Salaheddin Mahmud
INTRODUCTION: During their lives, 1 in 8 men will be diagnosed with prostate cancer. Several drugs have been shown to decrease prostate cancer risk, but have not been widely used in prostate cancer prevention because of concerns about side-effects and cost-effectiveness. Statins are indicated for prevention of cardiovascular disease, have an excellent benefit to risk profile, and some studies suggest that statins may reduce the risk of prostate cancer. MATERIALS AND METHODS: We performed a systematic search of Medline (Ovid), EMBASE (Ovid), and PubMed...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29260508/a-systematic-review-of-the-cost-effectiveness-of-biologics-for-ulcerative-colitis
#20
REVIEW
Ewa Stawowczyk, Paweł Kawalec
BACKGROUND: Ulcerative colitis (UC) is a chronic autoimmune inflammation of the colon. The condition significantly decreases quality of life and generates a substantial economic burden for healthcare payers, patients and the society in which they live. Some patients require chronic pharmacotherapy, and access to novel biologic drugs might be crucial for long-term remission. The analyses of cost-effectiveness for biologic drugs are necessary to assess their efficiency and provide the best available drugs to patients...
December 19, 2017: PharmacoEconomics
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