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systematic inflammation

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https://www.readbyqxmd.com/read/28632925/a-kallikrein-targeting-rna-aptamer-inhibits-the-intrinsic-pathway-of-coagulation-and-reduces-bradykinin-release
#1
K-A Steen-Burrell, J Layzer, B A Sullenger
BACKGROUND: Plasma kallikrein is a serine protease that plays an integral role in many biological processes including coagulation, inflammation, and fibrinolysis. The main function of kallikrein in coagulation is the amplification of activated factor XIIa (FXIIa) generation which ultimately leads to thrombin generation and fibrin clot formation. Kallikrein is generated by FXIIa-mediated cleavage of the zymogen, prekallikrein which is usually complexed with the nonenzymatic cofactor, high-molecular-weight kininogen (HK)...
June 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28627664/sodium-tanshinone-iia-sulfonate-suppresses-heat-stress-induced-endothelial-cell-apoptosis-by-promoting-no-production-through-upregulating-the-pi3k-akt-enos-pathway
#2
Qing Cheng, Yan Zhao, Jianguo Li
Heat shock is a life-threatening disease involving systematic inflammation that is closely related to endothelial injury and can lead to multiple organ dysfunction syndrome. Sodium tanshinone IIA sulfonate (STS) has various functions in the vascular endothelium. In the present study, STS is presented to suppress heat stress‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and high ambient temperature‑induced systematic inflammation in Sprague Dawley rats. In addition, the STS apoptosis‑suppression mechanism was explored...
June 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627071/oral-health-status-of-children-and-adolescents-with-intellectual-disabilities-a-systematic-review-and-meta-analysis
#3
REVIEW
Ni Zhou, Hai Ming Wong, Yi Feng Wen, Colman Mcgrath
AIM: To compare the oral health status of children and adolescents affected by intellectual disabilities with their unaffected counterparts. METHOD: Citations published in English were searched from electronic databases (PubMed, Embase, Web of Science, and Scopus) from their start dates to March 2017. The whole process was conducted following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. The PICO (population, intervention/interest, comparator, outcome) principle was used to formulate the topic...
June 19, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28621946/the-acute-effects-of-fine-particulate-matter-constituents-on-blood-inflammation-and-coagulation
#4
Cong Liu, Jing Cai, Renjie Chen, Liping Qiao, Hongli Wang, Wenxi Xu, Huichu Li, Zhuohui Zhao, Haidong Kan
Limited evidence is available on the effects of various fine particulate matter (PM2.5) constituents on blood inflammation and coagulation. We examined the associations between 10 constituents and 10 circulating biomarkers in a panel of 28 urban residents with 4 repeated measurements in Shanghai, China. Based on the linear mixed-effect models, we fitted the single-constituent models, the constituent-PM2.5 joint models, and the constituent-residual models to evaluate the associations between PM2.5 constituents and 8 inflammatory biomarkers (fibrinogen, C-reactive protein, monocyte chemoattractant protein-1, tumor necrosis factor-α, interleukin-1b, intercellular adhesion molecule-1, P-selectin, vascular cell adhesion molecule-1) and 2 coagulation biomarkers (plasminogen activator inhibitor-1 and soluble CD40 ligand)...
June 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28620061/whole-body-magnetic-resonance-imaging-in-inflammatory-arthritis-systematic-literature-review-and-first-steps-toward-standardization-and-an-omeract-scoring-system
#5
Mikkel Østergaard, Iris Eshed, Christian E Althoff, Rene P Poggenborg, Torsten Diekhoff, Simon Krabbe, Sabine Weckbach, Robert G W Lambert, Susanne J Pedersen, Walter P Maksymowych, Charles G Peterfy, Jane Freeston, Paul Bird, Philip G Conaghan, Kay-Geert A Hermann
OBJECTIVE: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis...
June 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28619548/review-emerging-concepts-in-the-pathogenesis-of-tendinopathy
#6
REVIEW
Benjamin J F Dean, Stephanie G Dakin, Neal L Millar, Andrew J Carr
Tendinopathy is a common clinical problem and has a significant disease burden attached, not only in terms of health care costs, but also for patients directly in terms of time off work and impact upon quality of life. Controversy surrounds the pathogenesis of tendinopathy, however the recent systematic analysis of the evidence has demonstrated that many of the claims of an absence of inflammation in tendinopathy were more based around belief than robust scientific data. This review is a summary of the emerging research in this topical area, with a particular focus on the role of neuronal regulation and inflammation in tendinopathy...
June 12, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28616286/severe-and-uncontrolled-asthma-in-china-a-cross-sectional-survey-from-the-australasian-severe-asthma-network
#7
Gang Wang, Fang Wang, Peter G Gibson, Michael Guo, Wei-Jie Zhang, Peng Gao, Hong-Ping Zhang, Erin S Harvey, Hui Li, Jie Zhang
BACKGROUND: Severe asthma is largely unexplored in the Chinese population. Patients with asthma underwent systematic evaluation, by investigating the characteristics of uncontrolled asthma and of asthma treated with three different controller therapies. METHODS: This multi-centre, real-world study was conducted from March 2014 to September 2015. Adults with stable asthma underwent assessment of medication use, asthma control, quality of life, psychological symptoms, work productivity and activity impairment, bronchodilator response and sputum induction...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616206/a-systematic-review-and-meta-analysis-of-genetic-association-studies-for-the-role-of-inflammation-and-the-immune-system-in-diabetic-nephropathy
#8
Maria Tziastoudi, Ioannis Stefanidis, Georgios M Hadjigeorgiou, Konstantinos Stravodimos, Elias Zintzaras
Background: Despite the certain contribution of metabolic and haemodynamic factors in diabetic nephropathy (DN), many lines of evidence highlight the role of immunologic and inflammatory mechanisms. To elucidate the contribution of the immune system in the development of DN, we explored the contribution of gene variants (polymorphisms) in relevant pathophysiologic pathways. Methods: We selected six major pathways related to immune response from the Kyoto Encyclopaedia of Genes and Genomes database and thereafter we traced all available genetic association studies (GASs) involving gene variants in these pathways from PubMed and HuGE Navigator...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28612257/peripheral-alterations-in-cytokine-and-chemokine-levels-after-antidepressant-drug-treatment-for-major-depressive-disorder-systematic-review-and-meta-analysis
#9
REVIEW
Cristiano A Köhler, Thiago H Freitas, Brendon Stubbs, Michael Maes, Marco Solmi, Nicola Veronese, Nayanna Q de Andrade, Gerwyn Morris, Brisa S Fernandes, André R Brunoni, Nathan Herrmann, Charles L Raison, Brian J Miller, Krista L Lanctôt, André F Carvalho
Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines and C-reactive protein. In addition, previous meta-analyses suggest that antidepressant drug treatment may decrease peripheral levels of interleukin-1 beta (IL-1β) and IL-6. Recently, several new studies examining the effect of antidepressants on these cytokines have been published, and so we performed an updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD...
June 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28611710/promising-links-between-meditation-and-reduced-brain-aging-an-attempt-to-bridge-some-gaps-between-the-alleged-fountain-of-youth-and-the-youth-of-the-field
#10
REVIEW
Florian Kurth, Nicolas Cherbuin, Eileen Luders
Over the last decade, an increasing number of studies has reported a positive impact of meditation on cerebral aging. However, the underlying mechanisms for these seemingly brain-protecting effects are not well-understood. This may be due to the fact, at least partly, that systematic empirical meditation research has emerged only recently as a field of scientific scrutiny. Thus, on the one hand, critical questions remain largely unanswered; and on the other hand, outcomes of existing research require better integration to build a more comprehensive and holistic picture...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28606571/effect-of-%C3%AF-3-polyunsaturated-fatty-acids-on-arthritic-pain-a%C3%A2-systematic-review
#11
REVIEW
Mozghan Abdulrazaq, Jacqueline K Innes, Philip C Calder
OBJECTIVES: Pain is a significant problem in rheumatoid arthritis (RA) and is associated with prostaglandins derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid. The ω-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid have been shown to reduce inflammation, with some studies showing clinical improvements in RA. The aim of this systematic review was to investigate the effect of ω-3 PUFAs on arthritic pain. METHOD: A systematic literature review of ω-3 PUFAs and pain associated with RA was performed up to December 2015...
July 2017: Nutrition
https://www.readbyqxmd.com/read/28606462/growing-literature-but-limited-evidence-a-systematic-review-regarding-prebiotic-and-probiotic-interventions-for-those-with-traumatic-brain-injury-and-or-posttraumatic-stress-disorder
#12
Lisa A Brenner, Kelly A Stearns-Yoder, Adam S Hoffberg, Molly E Penzenik, Amy J Starosta, Theresa D Hernández, Daniel A Hadidi, Christopher A Lowry
Traumatic brain injury (TBI) is highly prevalent among a wide-range of populations, including civilians, military personnel, and Veterans. TBI sequelae may be further exacerbated by symptoms associated with frequently occurring co-morbid psychiatric conditions including posttraumatic stress disorder (PTSD). This is particularly true among the population of military personnel from recent conflicts in Iraq and Afghanistan with a history of mild TBI (mTBI) and PTSD. The need for efficacious treatments for TBI and co-morbid PTSD is significant, and evidence-based interventions for these frequently co-occurring conditions are limited...
June 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28605395/possible-type-1-diabetes-risk-prediction-using-ultrasound-imaging-to-assess-pancreas-inflammation-in-the-inducible-autoimmune-diabetes-bbdr-model
#13
Frederick R Roberts, Clinton Hupple, Elaine Norowski, Nicole C Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M Van Dessel, Agata Jurczyk, David M Harlan, Dale L Greiner, Rita Bortell, Chaoxing Yang
BACKGROUND/AIMS: Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients, imaging technology to visualize pancreas inflammation is much in need. In this study, we investigated the feasibility of utilizing ultrasound imaging to assess pancreas inflammation longitudinally in living rats during the progression leading to type 1 diabetes onset. METHODS: The virus-inducible BBDR type 1 diabetes rat model was used to systematically investigate pancreas changes that occur prior to and during development of autoimmunity...
2017: PloS One
https://www.readbyqxmd.com/read/28604262/current-evidence-on-the-socket-shield-technique-a-systematic-review
#14
Amit Srikant Gharpure, Neel B Bhatavadekar
The recently popularised socket-shield technique involves intentional retention of a section of the remnant root at the time of immediate implant placement to preserve the buccal/proximal bone from resorption. The objective of this systematic review was to assess the literature available on the socket-shield technique and weigh its biological plausibility and long-term clinical prognosis. A Systematic Search was performed in PubMed-Medline, Embase, Web of Knowledge, Google Scholar and Cochrane Central for clinical/ animal studies up to April 2017...
June 12, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28603092/crosstalk-of-liver-immune-cells-and-cell-death-mechanisms-in-different-murine-models-of-liver-injury-and-its-clinical-relevance
#15
Hilal Ahmad Khan, Muhammad Zishan Ahmad, Junaid Ali Khan, Muhammad Imran Arshad
BACKGROUND: Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay of these inflammatory mediators and switching of immune responses during hepatotoxic, viral, drug-induced and immune cell-mediated hepatitis decide the fate of liver pathology. The present review aimed to describe the mechanisms of liver injury, its relevance to human liver pathology and insights for the future therapeutic interventions...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28601837/development-of-a-core-outcome-set-for-clinical-trials-in-inflammatory-bowel-disease-study-protocol-for-a-systematic-review-of-the-literature-and-identification-of-a-core-outcome-set-using-a-delphi-survey
#16
Christopher Ma, Remo Panaccione, Richard N Fedorak, Claire E Parker, Reena Khanna, Barrett G Levesque, William J Sandborn, Brian G Feagan, Vipul Jairath
INTRODUCTION: Crohn's disease (CD) and ulcerative colitis (UC), the main forms of inflammatory bowel disease (IBD), are chronic, progressive and disabling disorders of the gastrointestinal tract. Although data from randomised controlled trials (RCTs) provide the foundation of evidence that validates medical therapy for IBD, considerable heterogeneity exists in the measured outcomes used in these studies. Furthermore, in recent years, there has been a paradigm shift in IBD treatment targets, moving from symptom-based scoring to improvement or normalisation of objective measures of inflammation such as endoscopic appearance, inflammatory biomarkers and histological and radiographic end points...
June 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28601400/omega-3-fatty-acids-in-cardiovascular-disease-risk-factors-an-updated-systematic-review-of-randomised-clinical-trials
#17
REVIEW
Oscar D Rangel-Huerta, Angel Gil
Several studies and reviews regarding the supplementation of omega-3 LC-PUFAs have been developed during the last years. Indeed, the evidence states that high doses omega-3 LC-PUFAs produce a small but significant decrease in blood pressure in older and hypertensive subjects. Due to the increasing interest in the benefits of LC-PUFAs, we aimed to evaluate the scientific evidence provided in the past five years (2012-2016) on the effects of the intake of omega-3 LC-PUFAs on cardiovascular risk factors such as inflammation and oxidative stress, through a systematic review in PubMed database...
May 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28600966/inflammatory-cytokines-in-normal-and-irreversibly-inflamed-pulps-a-systematic-review
#18
REVIEW
Vivian Hirsch, Michael Wolgin, Aleksandr V Mitronin, Andrej M Kielbassa
OBJECTIVE: To review the available literature in regard to the inflammatory process and pulpitis. Setting forth to evaluate if differences in the levels of various cytokines (TNF-α, IL-1β, IL-2, IL-6 and IL-8) can be observed in clinically diagnosed normal and irreversibly inflamed pulps that could serve as possible markers and/or diagnostic tools to predict and differentiate between certain states of inflammation. Methods used to measure and assess levels of cytokines have been limited to two protein quantification methods ELISA and/or Multiplex Array...
June 1, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28598762/efficacy-of-arginine-enriched-enteral-formulas-for-the-healing-of-pressure-ulcers-a-systematic-review
#19
P Liu, W-Q Shen, H-L Chen
OBJECTIVE: Arginine improves healing and modulates inflammation and the immune response. This systematic review aimed to assess the effect of arginine-enriched enteral formulas in pressure ulcer (PU) healing. METHOD: Systematic computerised searches of PubMed, Web of Knowledge, Scopus, ENTRAL and CINAHL databases were performed from their inception to 20 January 2016. Randomised controlled trials (RCTs) were included in this systematic review. We used the Jadad scale as a quality assessment tool...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28598564/withdrawn-celecoxib-for-rheumatoid-arthritis
#20
REVIEW
Sarah E Garner, Dogan Fidan, Ruth R Frankish, Maria Judd, Beverley Shea, Tanveer Towheed, Peter Tugwell, George A Wells
BACKGROUND: Rheumatoid arthritis (RA) is a systemic auto-immune disorder, involving persistent joint inflammation. NSAIDs are used to control the symptoms of RA, but are associated with significant gastro-intestinal toxicity, including a risk of potentially life threatening gastroduodenal perforations, ulcers and bleeds. The NSAIDs known as the selective Cox II inhibitors, of which celecoxib is a member, were developed in order to reduce the GI toxicity, but are more expensive. OBJECTIVES: To establish the efficacy and safety of celecoxib in the management of RA by systematic review of available evidence...
June 9, 2017: Cochrane Database of Systematic Reviews
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