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https://www.readbyqxmd.com/read/29144584/3d-printed-anchoring-sutures-for-permanent-shaping-of-tissues
#1
Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang
Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29138800/broadleaf-mahonia-attenuates-granulomatous-lobular-mastitis%C3%A2-associated-inflammation-by-inhibiting-ccl%C3%A2-5-expression-in-macrophages
#2
Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin
Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29137051/neutrophil-to-lymphocyte-and-aspartate-to-alanine-aminotransferase-ratios-predict-hepatocellular-carcinoma-prognosis-after-transarterial-embolization
#3
Chang Liu, Bang-Sheng Jia, Bing-Wen Zou, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Li Jiang, Tian-Fu Wen, Wu-Sheng Lu
The neutrophil-to-lymphocyte ratio (NLR) reflects the systematic inflammatory status, and the aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) is a biomarker of liver fibrosis and cirrhosis. These values can be conveniently obtained from routine blood tests; however, their combined clinical utility has not been extensively studied in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). This study aimed to investigate the prognostic value of NLR-AAR in patients with unresectable HCC undergoing TACE...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134927/cerebral-amyloid-angiopathy-associated-with-inflammation-a-systematic-review-of-clinical-and-imaging-features-and-outcome
#4
Andrej Corovic, Siobhan Kelly, Hugh S Markus
Background Cerebral amyloid angiopathy associated with inflammation is an increasingly recognized condition, characterized by an inflammatory response to the vascular deposits of β-amyloid within the brain that are the hallmark of cerebral amyloid angiopathy. Two main patterns of this inflammatory response have been identified to date: one involving a perivascular inflammatory cell infiltrate (cerebral amyloid angiopathy-related inflammation); the other a transmural vasculitic process (A-beta related angiitis)...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29134239/temporomandibular-joint-atlas-for-detection-and-grading-of-juvenile-idiopathic-arthritis-involvement-by-magnetic-resonance-imaging
#5
Christian J Kellenberger, Thitiporn Junhasavasdikul, Mirkamal Tolend, Andrea S Doria
Contrast-enhanced magnetic resonance imaging (MRI) is considered the diagnostic standard for identifying involvement of the temporomandibular joint by juvenile idiopathic arthritis. Early or active arthritis is shown as bone marrow oedema, joint effusion, synovial thickening and increased joint enhancement. Subsequent joint damage includes characteristic deformity of the mandibular condyle, bone erosion, disk abnormalities and short mandibular ramus due to impaired growth. In this pictorial essay, we illustrate normal MRI findings and growth-related changes of the temporomandibular joint in children...
November 13, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29133016/dynamic-transcriptional-control-of-macrophage-mirna-signature-via-inflammation-responsive-enhancers-revealed-using-a-combination-of-next-generation-sequencing-based-approaches
#6
Zsolt Czimmerer, Attila Horvath, Bence Daniel, Gergely Nagy, Ixchelt Cuaranta-Monroy, Mate Kiss, Zsuzsanna Kolostyak, Szilard Poliska, Laszlo Steiner, Nikolas Giannakis, Tamas Varga, Laszlo Nagy
MicroRNAs are important components of the post-transcriptional fine-tuning of macrophage gene expression in physiological and pathological conditions. However, the mechanistic underpinnings and the cis-acting genomic factors of how macrophage polarizing signals induce miRNA expression changes are not well characterized. Therefore, we systematically evaluated the transcriptional basis underlying the inflammation-mediated regulation of macrophage microRNome using the combination of different next generation sequencing datasets...
November 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29130314/determining-psychoneuroimmunologic-markers-of-yoga-as-an-intervention-for-persons-diagnosed-with-ptsd-a-systematic-review
#7
Ursula Ann Kelly, Dian Dowling Evans, Helen Baker, Jessica Noggle Taylor
There is a growing body of research on yoga as a therapeutic intervention for psychological symptoms of post-traumatic stress disorder (PTSD) accompanied by speculations on underlying physiologic mechanisms. The purpose of this systematic review is to identify, qualitatively evaluate, and synthesize studies of yoga as an intervention for PTSD that measured physiologic outcomes in order to gain insights into potential mechanisms. The focus is on studies evaluating yoga as a therapeutic intervention for PTSD rather than for trauma exposure, PTSD prevention, or subclinical PTSD...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/29128574/conjunctivochalasis-a-systematic-review
#8
REVIEW
Anna Marmalidou, Ahmad Kheirkhah, Reza Dana
Conjunctivochalasis (CCH) is a conjunctival condition characterized by loose, redundant conjunctival folds, most typically in the inferior bulbar conjunctiva of both eyes. Although CCH is a common cause of ocular irritation and discomfort, especially in the elderly, it is often overlooked in clinical practice. Conjunctivochalasis may be associated with various ocular and non-ocular conditions; however, the most important risk factor is aging. Although often asymptomatic, CCH may cause symptoms related to tear film instability and/or delayed tear clearance...
November 8, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29125555/work-stress-and-altered-biomarkers-a-synthesis-of-findings-based-on-the-effort-reward-imbalance-model
#9
REVIEW
Johannes Siegrist, Jian Li
While epidemiological studies provide statistical evidence on associations of exposures such as stressful work with elevated risks of stress-related disorders (e.g., coronary heart disease or depression), additional information on biological pathways and biomarkers underlying these associations is required. In this contribution, we summarize the current state of the art on research findings linking stressful work, in terms of an established theoretical model-effort-reward imbalance-with a broad range of biomarkers...
November 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29119922/polyphenols-anti-platelet-nutraceutical
#10
Valeria Ludovici, Jens Barthelmes, Matthias P Nägele, Andreas J Flammer, Isabella Sudano
BACKGROUND: Coronary artery disease (CAD) is a disease progressing over many years. Genetic factors, as well as the exposure to risk factors, are continuously leading to endothelial dysfunction, vascular alterations and, eventually, organ damage, major cardiovascular events and deaths. Oxidative stress, platelet hyperactivity and low-grade inflammation are important modulators in this context, contributing to plaque formation. Since platelet activation plays a critical role in the development and progression of atherothrombotic events, the inhibition of platelet hyperactivity may contribute to decreased atherothrombotic risk...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29118111/differential-cell-matrix-mechanoadaptations-and-inflammation-drive-regional-propensities-to-aortic-fibrosis-aneurysm-or-dissection-in-hypertension
#11
M R Bersi, R Khosravi, A J Wujciak, D G Harrison, J D Humphrey
The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of the aorta. Yet, it remains unclear why certain diseases manifest differentially along the aorta. Toward this end, myriad animal models provide insight into diverse disease conditions-including fibrosis, aneurysm and dissection-but inherent differences across models impede general interpretations. We examined region-specific cellular, matrix, and biomechanical changes in a single experimental model of hypertension and atherosclerosis, which commonly coexist...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29117112/in-vivo-imaging-of-microglial-calcium-signaling-in-brain-inflammation-and-injury
#12
REVIEW
Petr Tvrdik, M Yashar S Kalani
Microglia, the innate immune sentinels of the central nervous system, are the most dynamic cells in the brain parenchyma. They are the first responders to insult and mediate neuroinflammation. Following cellular damage, microglia extend their processes towards the lesion, modify their morphology, release cytokines and other mediators, and eventually migrate towards the damaged area and remove cellular debris by phagocytosis. Intracellular Ca(2+) signaling plays important roles in many of these functions. However, Ca(2+) in microglia has not been systematically studied in vivo...
November 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29116046/radon-enriched-hot-spring-water-therapy-for-upper-and-lower-respiratory-tract-inflammation
#13
Desiderio Passali, Giacomo Gabelli, Giulio Cesare Passali, Ralph Mösges, Luisa Maria Bellussi
Background Radon-222-enriched hot spring therapy, which is characterized by a safe level of radioactivity, is used for the treatment of rheumatic disorders, and its efficacy has already been studied in several clinical trials. Radon-water inhalation therapy for the treatment of upper and lower airway inflammatory diseases is used in many hot springs centers. However, its application has not been reviewed to date. Methods We systematically searched the PubMed and Scopus databases for clinical trials published in the last 20 years in which objective parameters of upper and lower airway function had been tested before and after radon-enriched inhalation treatment...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29114647/the-effect-of-orthodontic-treatment-on-periodontal-tissue-inflammation-a-systematic-review
#14
Carmine Verrusio, Vincenzo Iorio-Siciliano, Andrea Blasi, Stefania Leuci, Daniela Adamo, Michele Nicolò
OBJECTIVE: The aim of the present systematic review was to evaluate the periodontal tissue inflammation indexes in patients undergoing different orthodontic treatment. METHOD AND MATERIALS: The Cochrane Oral Health Group specialist trials, Medline, and Embase databases were used for the research. All the included studies had to report bleeding on probing (BOP) depth as primary outcome. Changes in probing depth, clinical attachment level, Gingival Index, and Periodontal Index were included in the review as secondary outcome measurements...
November 7, 2017: Quintessence International
https://www.readbyqxmd.com/read/29111078/electroconvulsive-therapy-depression-the-immune-system-and-inflammation-a-systematic-review
#15
REVIEW
Antoine Yrondi, Marie Sporer, Patrice Péran, Laurent Schmitt, Christophe Arbus, Anne Sauvaget
BACKGROUND: The management and treatment of major depressive disorder are major public health challenges, the lifetime prevalence of this illness being 4.4%-20% in the general population. Major depressive disorder and treatment resistant depression appear to be, in part, related to a dysfunction of the immune response. Among the treatments for depression ECT occupies an important place. The underlying cerebral mechanisms of ECT remain unclear. OBJECTIVES/HYPOTHESIS: The aim of this review is to survey the potential actions of ECT on the immuno-inflammatory cascade activated during depression...
October 19, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29108829/tnf-inhibitors-in-rheumatoid-arthritis-and-spondyloarthritis-are-they-the-same
#16
REVIEW
Andrea Rubbert-Roth, Fabiola Atzeni, Ignazio Francesco Masala, Roberto Caporali, Carlomaurizio Montecucco, Piercarlo Sarzi-Puttini
The advent of anti-tumour necrosis factor (TNF) drugs for rheumatoid arthritis (RA) or spondyloarthritis (SpA) has revolutionised the approach to patients with active disease who do not respond to conventional therapy. Although there are differences in their structure, morphology, pharmacokinetic properties and activity, all anti-TNF drugs ultimately neutralise the TNFα pathway of inflammation. However, despite their similar clinical efficacy, there are disagreements concerning drug survival and safety, with systematic reviews and meta-analyses confirming one result or the other...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29107968/the-trophoblast-survival-capacity-in-preeclampsia
#17
Martina Hutabarat, Noroyono Wibowo, Berthold Huppertz
BACKGROUND: Preeclampsia has become the world's major maternal health problem putting a huge burden on mothers, newborns and also on the health systems. The pathogenesis of preeclampsia seems to include events in very early pregnancy affecting differentiation of placental villous trophoblast. The arising changes of the cell death spectrum from apoptosis via increased autophagy and aponecrosis to necrosis in turn induce systemic inflammation of the mother. METHODS: Placental tissue samples and maternal serum samples from 40 pregnant women were collected from normal pregnancy, IUGR, early-onset and late-onset preeclampsia...
2017: PloS One
https://www.readbyqxmd.com/read/29102433/effect-of-vitamin-d-supplementation-on-non-skeletal-disorders-a-systematic-review-of-meta-analyses-and-randomised-trials
#18
REVIEW
Philippe Autier, Patrick Mullie, Alina Macacu, Miruna Dragomir, Magali Boniol, Kim Coppens, Cécile Pizot, Mathieu Boniol
Randomised trials reported up to Dec 31, 2012, did not confirm that vitamin D supplementation could protect from non-skeletal health conditions affecting adults, as was expected on the basis of data from observational studies. To examine whether the more recently published meta-analyses and trials would change past conclusions, we systematically reviewed meta-analyses of vitamin D supplementation and non-skeletal disorders published between Jan 1, 2013, and May 31, 2017, that included study participants of all ages, including pregnant women...
October 25, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29100403/lactobacillus-reuteri-zj617-maintains-intestinal-integrity-via-regulating-tight-junction-autophagy-and-apoptosis-in-mice-challenged-with-lipopolysaccharide
#19
Yanjun Cui, Li Liu, Xiaoxiao Dou, Chong Wang, Wenming Zhang, Kan Gao, Jianxin Liu, Haifeng Wang
Live probiotics are effective in reducing gut permeability and inflammation. We have previously reported that Lactobacillus reuteri ZJ617 (ZJ617) with high adhesive and Lactobacillus rhamnosus GG (LGG) can ameliorate intestine inflammation induced by lipopolysaccharide (LPS). The present study was aimed at elucidating the roles of ZJ617 and LGG in alleviating the LPS-induced barrier dysfunction of ileum in mice. Six C57BL/6 mice per group were orally inoculated with ZJ617 or LGG for one week (1× 10(8) CFU/mouse) and intraperitoneally injected with LPS (10 mg/kg body weight) for 24 h...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098839/-systematic-review-of-chuankezhi-injection-for-treating-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#20
Shi-Qi Chen, Xin-Yu Yang, Xiao-Yi Tang, Min Li, Shuo Liu, Jing Liang, Xiao-Yu Zhang, Hong-Cai Shang
To evaluate the inflammatory factors, the pulmonary function, the efficiency and the safety of Chuankezhi injection for treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The randomized controlled trials (RCTs) on Chuankezhi injection for treating AECOPD were collected from 7 databases (PubMed, CNKI, et al) between inception to November 2016. Two reviewers independently screened literature and extracted the data according to the inclusion and exclusion criteria, and assessed methodological quality of included studies according to the criteria from Cochrane Reviewer's Handbook 5...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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