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https://www.readbyqxmd.com/read/29342119/novel-hybrid-formulations-based-on-thiourea-derivatives-and-core-shell-fe%C3%A2-o%C3%A2-c18-nanostructures-for-the-development-of-antifungal-strategies
#1
Carmen Limban, Alexandru Vasile Missir, Miron Teodor Caproiu, Alexandru Mihai Grumezescu, Mariana Carmen Chifiriuc, Coralia Bleotu, Luminita Marutescu, Marius Toma Papacocea, Diana Camelia Nuta
The continuously increasing global impact of fungal infections is requiring the rapid development of novel antifungal agents. Due to their multiple pharmacological activities, thiourea derivatives represent privileged candidates for shaping new drugs. We report here the preparation, physico-chemical characterization and bioevaluation of hybrid nanosystems based on new 2-((4-chlorophenoxy)methyl)-N-(substituted phenylcarbamo-thioyl)benzamides and Fe₃O₄@C18 core@shell nanoparticles. The new benzamides were prepared by an efficient method, then their structure was confirmed by spectral studies and elemental analysis and they were further loaded on Fe₃O₄@C18 nanostructures...
January 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29341924/maca-polysaccharides-a-review-of-compositions-isolation-therapeutics-and-prospects
#2
REVIEW
Yujuan Li, Fangxue Xu, Mengmeng Zheng, Xiaozhi Xi, Xiaowei Cui, Chunchao Han
Maca polysaccharides, some of the major bioactive substances in Lepidium meyenii (Walp.) (Maca), have various biological properties, including anti-oxidant, anti-fatigue, anti-tumor, and immunomodulatory effects, as well as hepatoprotective activity and regulation function. Although many therapeutics depend on multiple structures of maca polysaccharides in addition to providing sufficient foundations for maca polysaccharide products in industrial applications, the relationships between the pharmacological effects and structures have not been established...
January 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29341327/involvement-of-the-dorsal-hippocampus-in-expression-and-extinction-of-cocaine-induced-conditioned-place-preference
#3
Leah N Hitchcock, K Matthew Lattal
A key aspect of substance abuse is that drug taking often occurs in a specific context. As a consequence, exposure to drug-associated contexts can trigger cravings and relapse, even after long periods of abstinence. Although many studies have demonstrated that the hippocampus is critical for developing and retrieving contextual and spatial memories, comparatively little is known about the role of the hippocampus in acquiring and inhibiting memories involving contexts and drugs of abuse. We examined the effects of hippocampal inactivation on expression of cocaine-induced conditioned place preference (CPP) after initial acquisition or extinction of CPP in C57BL/6 mice...
January 17, 2018: Hippocampus
https://www.readbyqxmd.com/read/29339599/full-scale-performance-of-selected-starch-based-biodegradable-polymers-in-sludge-dewatering-and-recommendation-for-applications
#4
Kuangxin Zhou, Johan Stüber, Rabea-Luisa Schubert, Christian Kabbe, Matthias Barjenbruch
Agricultural reuse of dewatered sludge is a valid route for sludge valorization for small and mid-size wastewater treatment plants (WWTPs) due to the direct utilization of nutrients. A more stringent of German fertilizer ordinance requires the degradation of 20% of the synthetic additives like polymeric substance within two years, which came into force on 1 January 2017. This study assessed the use of starch-based polymers for full-scale dewatering of municipal sewage sludge. The laboratory-scale and pilot-scale trials paved the way for full-scale trials at three WWTPs in Germany...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29338751/evaluation-of-the-effects-of-a-designated-program-on-illegal-drug-cessation-among-adolescents-who-experiment-with-drugs
#5
Chiu-Ching Chang, Jung-Yu Liao, Chiu-Mieh Huang, Hsiao-Pei Hsu, Chih-Che Chen, Jong-Long Guo
BACKGROUND: Studies indicate that adolescent-onset drug users experience a greater likelihood of dependence that continues into adulthood. The importance of early intervention was evident in treating adolescents before their substance use progressed. We examined the effectiveness of an intervention program that prevents students who experiment with drugs from reusing them. METHODS: The study was based on 10 out of 18 invited schools that were randomly assigned to either the intervention group (5 schools, n = 43) or the comparison group (5 schools, n = 41)...
January 16, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29337671/spectrophotometric-method-for-simultaneous-determination-of-valsartan-and-substances-from-the-group-of-statins-in-binary-mixtures
#6
Mariusz Stolarczyk, Anna Apola, Anna Maślanka, Anna Kwiecień, Włodzimierz Opoka
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337399/impact-of-pregnancy-on-psychoactive-substance-use-among-women-with-substance-use-disorders-recruited-in-addiction-specialized-care-centers-in-france
#7
Liselotte Pochard, Julie Dupouy, Elisabeth Frauger, Adeline Giocanti, Joëlle Micallef, Maryse Lapeyre-Mestre
Pregnancy can be a motivation for decrease in drug abusing but may also represent a period of high vulnerability for relapse.We aimed to assess psychoactive substance use among women with substance use disorders followed in addiction care centers in France. We analyzed data from women aged 15-44 years included in the 'Observation of illegal drugs and misuse of psychotropic medication survey' (OPPIDUM), an annualcross-sectional survey collecting details on psychoactive substances used. Characteristics of women included in 2005 to 2012 yearly surveys were compared depending on their pregnant or not pregnant status...
January 16, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29336931/impact-of-crack-cocaine-use-on-the-occurrence-of-oral-lesions-and-micronuclei
#8
R P Antoniazzi, F B Lago, L C Jardim, M R Sagrillo, K L Ferrazzo, C A Feldens
The aim of this study was to investigate the occurrence of oral lesions and micronuclei in crack cocaine users. A cross-sectional study was conducted involving 106 crack users and 106 non-users matched for age, sex, and tobacco use. Socio-demographic characteristics, the consumption of psychoactive substances, and the occurrence of fundamental lesions were investigated. Cellular changes in the oral mucosa (karyolysis, karyorrhexis, 'broken egg' events, and micronuclei) were determined by exfoliative cytology for 54 participants in each group...
January 11, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29334656/activated-protein-c-suppresses-osteoclast-differentiation-via-endothelial-protein-c-receptor-protease-activated-receptor-1-sphingosine-1-phosphate-receptor-and-apolipoprotein-e-receptor-2
#9
Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
INTRODUCTION: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that anticoagulant activated protein C (APC) promotes osteoblast proliferation, but the role of the blood coagulation system in bone remodeling remains unclear. In this study, to further elucidate the relationship between bone remodeling and blood coagulation, we investigated the effect of APC on osteoclast differentiation...
January 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29334513/opioid-use-disorders-attributed-to-tramadol-among-egyptian-university-students
#10
Medhat M Bassiony, Mohamed Abdelghani, Ghada M Salah El-Deen, Mervat S Hassan, Hayam El-Gohari, Usama M Youssef
BACKGROUND: Tramadol use is an overwhelming problem in Egypt with tremendous medical and social consequences especially among youth. Use liability among Egyptian university students is underevaluated. This study aimed to estimate the prevalence and associated correlates of tramadol use among students from Zagazig University, Egypt. METHODS: A cross-sectional study included a total of 1135 undergraduate students, from 10 colleges in Zagazig University. Participants were randomly selected and assessed for tramadol use using The Drug Use Disorders Identification Test (DUDIT) and The Drug Use Disorders Identification Test-Extended (DUDIT-E)...
January 12, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29333664/increased-non-fatal-overdose-risk-associated-with-involuntary-drug-treatment-in-a-longitudinal-study-with-people-who-inject-drugs
#11
Claudia Rafful, Ricardo Orozco, Gudelia Rangel, Peter Davidson, Dan Werb, Leo Beletsky, Steffanie A Strathdee
AIM: To assess the effect of involuntary drug treatment (IDT) on non-fatal overdose among people who inject drugs (PWID). DESIGN: Longitudinal study. SETTING: Tijuana, Mexico. PARTICIPANTS: Baseline sample of 671 PWID included 258 (38.4%) women and 413 (61.6%) men. MEASUREMENTS: Primary independent variables were reported recent (i.e., past 6 months) non-fatal overdose event (dependent variable) and IDT...
January 14, 2018: Addiction
https://www.readbyqxmd.com/read/29333632/binding-of-cu-and-cu2-with-peptides-peptides-oxytocin-arg8-vasopressin-bradykinin-angiotensin-i-substance-p-somatostatin-and-neurotensin
#12
Thankan Jayasekharan, Shyam L Gupta, Vikas Dhiman
The intrinsic binding ability of seven natural peptides (oxytocin, arg8 -vasopressin, bradykinin, angiotensin-I, substance-P, somatostatin, and neurotensin) with copper in two different oxidation states (CuI/II ) derived from different Cu+/2+ precursor sources have been investigated for their charge dependent binding characteristics. The peptide-CuI/II complexes, [M - (n-1)H + nCuI ] and [M - (2n-1)H + nCuII ] are prepared/generated by the reaction of peptides with CuI solution/Cu-target and CuSO4 solution, and are analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS)...
January 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29331733/aronia-melanocarpa-fruit-juice-ameliorates-the-symptoms-of-inflammatory-bowel-disease-in-tnbs-induced-colitis-in-rats
#13
Stefka Valcheva-Kuzmanova, Atanas Kuzmanov, Vasilena Kuzmanova, Maria Tzaneva
Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been proposed as mechanisms underlying the pathophysiology of IBD. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in polyphenolic substances, mainly proanthocyanidins, flavonoids and phenolic acids. The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29330606/the-associations-of-poor-psychiatric-well-being-among-incarcerated-men-with-injecting-drug-use-histories-in-victoria-australia
#14
Reece Cossar, Mark Stoové, Stuart A Kinner, Paul Dietze, Campbell Aitken, Michael Curtis, Amy Kirwan, James R P Ogloff
BACKGROUND: Dual substance dependence and psychiatric and psychological morbidities are overrepresented in prison populations and associated with reoffending. In the context of an increasing prison population in Australia, investigating the needs of vulnerable people in prison with a dual diagnosis can help inform in-prison screening and treatment and improve prison and community service integration and continuation of care. In this study we quantified psychiatric well-being in a sample of people in prison with a history of injecting drug use in Victoria, Australia, and identified factors associated with this outcome...
January 13, 2018: Health & Justice
https://www.readbyqxmd.com/read/29329763/efficacy-and-safety-of-varenicline-for-smoking-cessation-in-people-living-with-hiv-in-france-anrs-144-inter-activ-a-randomised-controlled-phase-3-clinical-trial
#15
Patrick Mercié, Julie Arsandaux, Christine Katlama, Samuel Ferret, Aurélie Beuscart, Christian Spadone, Claudine Duvivier, Jacques Reynes, Nathalie Wirth, Laetitia Moinot, Antoine Bénard, David Zucman, Xavier Duval, Jean-Michel Molina, Bruno Spire, Catherine Fagard, Geneviève Chêne
BACKGROUND: Tobacco smoking is common in people living with HIV, but high-quality evidence on interventions for smoking cessation is not available in this population. We aimed to assess the efficacy and safety of varenicline with counselling to aid smoking cessation in people living with HIV. METHODS: The ANRS 144 Inter-ACTIV randomised, parallel, double-blind, multicentre, placebo-controlled phase 3 trial was done at 30 clinical hospital sites in France. People living with HIV who had smoked at least ten cigarettes per day for 1 year or longer, were motivated to stop smoking, were not dependent on another psychoactive substance, and had no history of depression or suicide attempt were eligible...
January 9, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29328973/feeding-inhibition-in-corbicula-fluminea-o-f-muller-1774-as-an-effect-criterion-to-pollutant-exposure-perspectives-for-ecotoxicity-screening-and-refinement-of-chemical-control
#16
Bruno Branco Castro, Carlos Silva, Inês Patrunilho Efe Macário, Bruno Oliveira, Fernando Gonçalves, Joana Luísa Pereira
Bivalves are commonly used in biomonitoring programs to track pollutants. Several features, including its filter-feeding abilities, cumulatively argue in favour of the use of the Asian clam (Corbicula fluminea) as a biosentinel and an ecotoxicological model. Filtration in bivalves is very sensitive to external stimuli and its control is dictated by regulation of the opening/closure of the valves, which may be used as an avoidance defence against contaminants. Here, we investigate the filter-feeding behaviour of the Asian clam as an endpoint for assessing exposure to pollutants, driven by two complementary goals: (i) to generate relevant and sensitive toxicological information based on the ability of C...
January 4, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29328505/substance-p-as-a-putative-efferent-transmitter-mediates-gabaergic-inhibition-in-mouse-taste-buds
#17
Anthony Y Huang, Sandy Y Wu
BACKGROUND AND PURPOSE: Capsaicin-mediated modulation on taste nerve responses is thought to be produced indirectly by actions of neuropeptides, e.g., calcitonin gene-related peptide (CGRP) and substance P (SP), onto taste cells implying playing a role in taste sensitivity. During processing gustatory information in taste buds, CGRP shapes peripheral taste signals via serotonergic signaling. The underlying assumption has been that SP exerts its effects on taste transmitter secretion in taste buds of mice...
January 12, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29328059/a-simple-way-to-synthesis-larger-scale-cu-sub-2-sub-o-ag-nanoflower-for-ultrasensitive-surface-enhanced-raman-scattering-detection
#18
Junyan Zou, Weijia Song, Weiguang Xie, Bo Huang, Huidong Yang, Zhi Luo
Here, we report a simple strategy to prepare highly sensitive surface-enhanced Raman spectroscopy (SERS) substrates based on Ag decorated Cu<sub>2</sub>O nanoparticles by combing two commom techniques, viz, thermal oxidation growth of Cu<sub>2</sub>O nanoparticles and magnetron sputtering fabrication of Ag nanopartilce film. Methylene blue was used as raman analyte for the SERS study, and the substrates fabricated under optimized conditions have very good sensitivity (analytical enhancement facor ~10<sup>8</sup>) , stablility and reproducibility...
January 12, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29328022/-endometriosis-a-new-approach-to-etiology-and-pathogenesis-review
#19
A Solopova, A Makacarya, E Chukanova
Endometriosis is a dyshormonal immune-dependent genetically determined disease, which appears as an endometrioid tissue that grows outside the uterine. Endometriosis is one of the most urgent problems of medicine. To date, new concepts of the endometriosis etiology and pathogenesis have been developed, but, despite their abundance, there is no unified theory. Genetic and epigenetic factors result in changes in an expression of aromatase, steroidogenic factor 1, and estrogen receptors are suggested to be the main cause of endometriosis...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29327091/temporal-fluctuations-in-behavior-perceived-hiv-risk-and-willingness-to-use-pre-exposure-prophylaxis-prep
#20
Kristen Underhill, Kate M Guthrie, Christopher Colleran, Sarah K Calabrese, Don Operario, Kenneth H Mayer
Individual perceptions of HIV risk influence willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention. Among men who have sex with men (MSM) and male sex workers (MSWs), temporal or episodic changes in risk behavior may influence perceived risk and PrEP acceptability over time. We investigated fluctuations in perceived HIV risk and PrEP acceptability, comparing MSWs against MSM who do not engage in sex work. We conducted 8 focus groups (n = 38) and 56 individual interviews among MSM and MSWs in Providence, RI...
January 11, 2018: Archives of Sexual Behavior
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