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https://www.readbyqxmd.com/read/28446036/fusaripeptide-a-new-antifungal-and-anti-malarial-cyclodepsipeptide-from-the-endophytic-fungus-fusarium-sp
#1
Sabrin R M Ibrahim, Hossam M Abdallah, Ehab S Elkhayat, Nawal M Al Musayeib, Hani Z Asfour, Mohamed F Zayed, Gamal A Mohamed
From the culture of the endophytic fungus Fusarium sp. isolated from the roots of Mentha longifolia L. (Labiatae) growing in Saudi Arabia, a new cyclodepsipeptide, namely fusaripeptide A (1), along with three known compounds adenosine (2), 2[(2-hydroxypropionyl)amino]benzamide (3), and cyclopentanol (4), have been isolated. Their structures were determined, using extensive 1D and 2D NMR and HRESI and GC mass spectral data. That is the first report for the isolation of compound 4 from natural source. In addition, compounds 2 and 3 are reported here for the first time from Fusarium sp...
April 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28433034/direct-1-h-nmr-evidence-of-spin-rotation-coupling-as-a-source-of-para-%C3%A2-ortho-h2-conversion-in-diamagnetic-solvents
#2
Camilla Terenzi, Sabine Bouguet-Bonnet, Daniel Canet
At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2. When p-H2 is dissolved in a diamagnetic organic solvent, conversion is very slow and can be considered as arising from nuclear spin relaxation phenomena. A first relaxation mechanism, specific to the singlet state and involving a combination of auto-correlation and cross correlation spectral densities, can be retained: randomly fluctuating magnetic fields due to inter-molecular dipolar interactions...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28431176/effect-of-melatonin-on-renewal-of-chicken-small-intestinal-mucosa
#3
J Li, R X Li, G Liu, C F Lv, Y L Mi, C Q Zhang
A higher concentration of melatonin (MEL) in the intestine - even more than that in the plasma and pineal gland - implies its putative important role in the gastrointestinal structural or functional regulation. However, little evidence has shown that MEL can regulate the physiological functions of the intestinal mucosa. In this study, fertilized chicken eggs were treated with MEL (0.1 to 10 μg/d) from embryonic d 12 (E12) to post-hatching d 6 (D6), and the small intestine samples were collected at D6 to determine the changes in mucosal construction and function...
April 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28418624/nickel-cornered-molecular-rectangles-as-polycyclic-aromatic-hydrocarbon-receptors
#4
Víctor Martínez-Agramunt, Sheila Ruiz-Botella, Eduardo Peris
Two nickel-cornered organometallic metalla-rectangles containing a pyrene-linked-di-N-heterocyclic carbene have been prepared. The dimensions of one side of the rectangle were modulated by either using pyrazine or 4,4'-bipyridine. The two molecules were tested as hosts for the recognition of seven small polycyclic aromatic hydrocarbons (PAHs) in [D6 ]acetone. By using (1) H NMR spectroscopy titrations, it could be established that the host-guest stoichiometries of the inclusion complexes formed were 1:1 for the pyrazine-based host, and 1:2 for the host containing bipyridine, in accordance with the larger dimensions of the latter...
April 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28402639/a-simple-approach-for-predicting-the-spin-state-of-homoleptic-fe-ii-tris-diimine-complexes
#5
Hoa Phan, Jeremy J Hrudka, Dilyara Igimbayeva, Latévi M Lawson Daku, Michael Shatruk
We propose a simple method for predicting the spin state of homoleptic complexes of the Fe(II) d(6) ion with chelating diimine ligands. The approach is based on the analysis of a single metric parameter within a free (noncoordinated) ligand: the interatomic separation between the N-donor metal-binding sites. An extensive analysis of existing complexes allows the determination of critical N···N distances that dictate the regions of stability for the high-spin and low-spin complexes, as well as the intermediate range in which the magnetic bistability (spin crossover) can be observed...
April 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28395348/exposure-assessment-in-a-single-walled-carbon-nanotube-primary-manufacturer
#6
Serge Kouassi, Cyril Catto, Claude Ostiguy, Gilles L'Espérance, Jens Kroeger, Maximilien Debia
Objectives: This study was aimed at documenting and characterizing occupational exposure to single-walled carbon nanotubes (SWCNTs) generated in a primary manufacturing plant. It also compared various strategies of exposure monitoring. Methods: A 6-day measurement protocol was scheduled (D1-D6) including both (i) quasi-personal monitoring with an array of direct reading instruments (DRIs) and (ii) offline electron microscopy analyses of surface and breathing zone filter-based samples...
March 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28389278/prenylated-flavonoids-from-the-stems-and-roots-of-tripterygium-wilfordii
#7
Yang Chen, Jianping Zhao, Yixing Qiu, Hanwen Yuan, Shabana I Khan, Nusrat Hussain, M Iqbal Choudhary, Feng Zeng, De-An Guo, Ikhlas A Khan, Wei Wang
Phytochemical investigation on the stems and roots of Tripterygium wilfordii led to the isolation and characterization of three new prenylated flavanones, tripteryols A-C (1-3), along with (±)-5,4'-dihydroxy-2'-methoxy-6',6″-dimethypyraro-(2″,3″:7,8)-6-methyflavanone (4), and ((2S)-5,7,4'-trihydroxy-2'-methoxy-8,5'-di(3-methyl-2-butenyl)-6-methylflavanone (5). Structures of the compounds 1-5 were elucidated using spectroscopic techniques, such as UV, IR, NMR (1D and 2D), and HRESI-MS. Tripteryols B (2) was found active in the antimicrobial assay against Cryptococcus neoformans, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with IC50 values in the range of 2...
April 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#8
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385033/a-new-procyanidin-b-from-campylospermum-zenkeri-ochnaceae-and-antiplasmodial-activity-of-two-derivatives-of-%C3%A2-serotobenine
#9
Norbert Mbabi Nyemeck, Dominique Serge Ngono Bikobo, Auguste Abouem A Zintchem, Eva-Maria Schäfer, Christian Bochet, Dieudonné Emmanuel Pegnyemb, Ulrich Koert
Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate activity against D6 and W2 strains of Plasmodium falciparum. For a better understanding of structure-activity relationships, three new semi-synthetic derivatives of serotobenine (2) have been prepared...
April 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28384957/radioprotective-effect-of-beta-d-glucan-and-vitamin-e-on-gamma-irradiated-mouse
#10
Faraj Tabeie, Seyed Mehdi Tabatabaei, Ali Mahmoud-Pashazadeh, Majid Assadi
INTRODUCTION: It is shown that beta-D-glucan is an immunologic system booster with radioprotectory effects. Radioprotectors are chemical components that can alleviate biological damage produced by ionizing radiation. AIM: This study was designed to investigate the synergistic radioprotectory effects of beta-D-glucan and vitamin E on irradiated mice with (60)Co source. MATERIALS AND METHODS: A total of 240 female mice were arranged in four, equal population groups of control group (C), treated group with beta D-glucan (G), treated group with vitamin E (E), and treated group with both beta D-glucan and vitamin E (G+E)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28365220/adaptation-of-running-pattern-to-the-drop-of-standard-cushioned-shoes-a-randomised-controlled-trial-with-a-6-month-follow-up
#11
Laurent Malisoux, Paul Gette, Nicolas Chambon, Axel Urhausen, Daniel Theisen
OBJECTIVES: While several cross-sectional studies have investigated the acute effects of shoe drop on running biomechanics, the long-term consequences are currently unknown. This study aimed to investigate if the drop of standard cushioned shoes induces specific adaptations in running technique over a six-month period in leisure-time runners. DESIGN: Double-blinded randomised controlled trial. METHODS: The participants (n=59) received a pair of shoes with a heel-to-toe drop of 10mm (D10), 6mm (D6) or 0mm (D0) and were followed-up regarding running training over 6 months or 500km, whichever came first...
March 18, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28362279/taking-the-halogen-bonding-hydrogen-bonding-competition-one-step-further-complexes-of-difluoroiodomethane-with-trimethylphosphine-dimethyl-sulfide-and-chloromethane
#12
Yannick Geboes, Frank De Proft, Wouter A Herrebout
To rationalize the driving factors in the competition of halogen bonding and hydrogen bonding, the complexes of the combined halogen-/hydrogen-bond donor difluoroiodomethane with the Lewis bases trimethylphosphine, dimethyl sulfide and chloromethane are studied. For all Lewis bases, ab initio calculations lead to halogen- and hydrogen-bonded complexes. Fourier transform-IR experiments involving solutions of mixtures of difluoroiodomethane with trimethylphosphine(-d9) or dimethyl sulfide(-d6) in liquid krypton confirm the coexistence of a halogen-bonded and hydrogen-bonded complex...
April 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28333961/phytochemical-investigation-of-aloe-pulcherrima-roots-and-evaluation-for-its-antibacterial-and-antiplasmodial-activities
#13
Dele Abdissa, Girma Geleta, Ketema Bacha, Negera Abdissa
Medicinal plants with documented traditional uses remain an important source for the treatment of a wide range of ailments. Evidence shows that majority of the Ethiopian population are still dependent on traditional medicine. Aloe pulcherrima Gilbert & Sebsebe is one of the endemic Aloe species traditionally used for the treatment of malaria and wound healing in central, Southern and Northern part of Ethiopia. The aim of the current study was, therefore, to isolate active compounds from roots of A. pulcherrima and evaluate for their antibacterial and antiplasmodial activities using standard test strains...
2017: PloS One
https://www.readbyqxmd.com/read/28332677/tuneable-reversible-redox-of-cobalt-iii-carbazole-complexes
#14
Michael S Bennington, Humphrey L C Feltham, Zoë J Buxton, Nicholas G White, Sally Brooker
Four tridentate carbazole-based ligands, HL((t)Bu/H) {3,6-di(tert-butyl)-1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole}, HL((t)Bu/(t)Bu) {3,6-di(tert-butyl)-1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, HL(H/H) {1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole} and HL(H/(t)Bu) {1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, were prepared and complexed with cobalt(ii) tetrafluoroborate. In situ air oxidation resulted in cobalt(iii) complexes 1-4 with the general formula [Co(III)(L)2]BF4·xH2O (1: L = L((t)Bu/H), x = 2; 2: L = L((t)Bu/(t)Bu), x = 1; 3: L = L(H/H), x = 0...
March 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28329216/heart-mechanics-at-high-altitude-6%C3%A2-days-on-the-top-of-europe
#15
Claire Maufrais, Thomas Rupp, Pierre Bouzat, Gregory Doucende, Samuel Verges, Stéphane Nottin, Guillaume Walther
Aims: The aim of this study was to analyse the underlying mechanisms of left and right ventricular (LV and RV) functional alterations during several days in high-altitude hypoxia. Methods and results: Resting evaluations of LV and RV function and mechanics were assessed by Speckle Tracking Echocardiography on 11 subjects at sea level (SLPRE), 3 ± 2 h after helicopter transport to high altitude (D0), at day 2 (D2), day 4 (D4) and day 6 (D6) at 4350 m and 5 ± 2 h after return to sea level (SLPOST)...
December 22, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28317225/cr-0-mo-0-and-w-0-isocyanide-complexes-as-luminophores-and-photosensitizers-with-long-lived-excited-states
#16
Laura A Büldt, Oliver S Wenger
Group 6 d6 metal complexes with arylisocyanide ligands are earth-abundant alternatives to photoactive complexes made from precious metals such as Ru(II), Re(I), Os(II), or Ir(III). Some of them have long-lived 3MLCT excited states that exhibit luminescence with good quantum yields combined with nano- to microsecond lifetimes, and they are very strongly reducing. Recent studies have demonstrated that Cr(0), Mo(0), and W(0) arylisocyanides have great potential for application in luminescent devices, photoredox catalysis, and dye-sensitized solar cells...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28315598/n-piperonyl-substitution-on-aminoquinoline-pyrimidine-hybrids-effect-on-the-antiplasmodial-potency
#17
Rohit Kholiya, Shabana I Khan, Aparna Bahuguna, Mohit Tripathi, Diwan S Rawat
A series of 4-aminoquinoline-piperonyl-pyrimidine hybrids were synthesized with the aim of identifying compounds with enhanced antimalarial activity. All the synthesized molecules were evaluated in vitro against cultured Plasmodium falciparum W2 and D6 strains and exhibited potent antiplasmodial activities with IC50 values in the range of 0.02-5.16 μM. Out of the 22 synthesised hybrids, 12 were found to be better (up to eight-fold more active) than chloroquine (CQ), particularly against the CQ-resistant W2 strain of P...
March 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28301802/illness-severity-and-biomarkers-in-depression-using-a-unidimensional-rating-scale-to-examine-bdnf
#18
Marco A Caldieraro, Edgar A Vares, Lívia H Souza, Lucas Spanemberg, Tadeu A Guerra, Bianca Wollenhaupt-Aguiar, Pâmela Ferrari, Andrew A Nierenberg, Marcelo P Fleck
BACKGROUND: Numerous studies have reported reduced peripheral brain-derived neurotrophic factor (BDNF) in major depression (MD). However, most of these studies used multidimensional depression rating scales, and failed to identify a relationship between BDNF levels and depression severity. Unidimensional scales are a more valid measure of syndrome severity. In these scales, items are ordered in increasing severity, so that as scores increase, syndrome severity increases; thus, each item adds unique information, and items can be totaled to a meaningful sum...
May 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28286597/extending-the-lifetime-of-hyperpolarized-propane-gas-through-reversible-dissolution
#19
Dudari B Burueva, Alexey S Romanov, Oleg G Salnikov, Vladimir V Zhivonitko, Yu-Wen Chen, Danila A Barskiy, Eduard Y Chekmenev, Dennis W Hwang, Kirill V Kovtunov, Igor V Koptyug
Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3...
March 2, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28280764/lipid-quantitation-and-metabolomics-data-from-vitamin-e-deficient-and-sufficient-zebrafish-embryos-from-0-to-120-hours-post-fertilization
#20
Melissa McDougall, Jaewoo Choi, Hye-Kyeong Kim, Gerd Bobe, J Frederik Stevens, Enrique Cadenas, Robert Tanguay, Maret G Traber
The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zebrafish (Danio rerio), fed defined diets without (E-) or with VitE (E+, 500 mg RRR-α-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at 24, 48, 72, 120 hours-post-fertilization, hpf), neurobehavioral development (locomotor responses at 96 hpf), and rescue strategies...
April 2017: Data in Brief
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