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https://www.readbyqxmd.com/read/29333875/ultrafast-determination-of-vitamin-e-using-lc-esi-ms-ms-for-preclinical-development-of-new-nutraceutical-formulations
#1
Noemi Villaseca-González, Virginia Rodríguez Robledo, Lucía Castro-Vázquez, María Victoria Lozano, Manuel J Santander-Ortega, Joaquín González-Fuentes, Pilar Marcos, María Del Mar Arroyo-Jiménez
AIM: We proposed a rapid and high quality method to determine α-tocopherol (α-T) in different biopharmaceutical samples using liquid chromatography-diode array detector on-line ESI-MS/MS. MATERIALS & METHODS: A working standard solution of α-T and internal standard, phenyl-5,7-dimethyl-d6-α-tocopherol, were used for optimization and validation of the method. Levels of α-T in nanoemulsions, serum and plasma samples were evaluated. RESULTS & CONCLUSION: Precision (1% for retention time, 5% for peak area and 3% for relative peak area), linearity range (among 0...
January 15, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29306111/deuterated-18f-9-o-hexadeutero-3-fluoropropoxyl-dihydrotetrabenazine-d6-fp-dtbz-a-vesicular-monoamine-transporter-2-vmat2-imaging-agent
#2
Futao Liu, Seok Rye Choi, Zhihao Zha, Karl Ploessl, Lin Zhu, Hank F Kung
INTRODUCTION: Vesicular monoamine transporters 2 (VMAT2) in the brain serve as transporter for packaging monoamine in vesicles for normal CNS neurotransmission. Several VMAT2 imaging agents, [11C]-(+)-DTBZ, dihydrotetrabenazine and [18F]FP-(+)-DTBZ (9-O-fluoropropyl-(+)-dihydro tetrabenazine, a.k.a. [18F]AV-133), are useful for studying the changes in brain function related to monoamine transmission by in vivo imaging. Deuterated analogs have been reported targeting VMAT2 binding sites...
December 6, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29304472/the-genome-sequence-of-escherichia-coli-tailed-phage-d6-and-the-diversity-of-enterobacteriales-circular-plasmid-prophages
#3
Eddie B Gilcrease, Sherwood R Casjens
The temperate Escherichia coli bacteriophage D6 can exist as a circular plasmid prophage, and we report here its 91,159bp complete genome sequence. It is a distant relative of the well-studied phage P1, but it is sufficiently different that it typifies a previously undescribed tailed phage type or cluster. Examination of the database of bacterial genome sequences revealed that phage P1 and D6 prophage plasmids are common in the Enterobacteriales, and in addition, previously described Salmonella phage SSU5 represents a different type of temperate tailed phage with a circular plasmid prophage that is also very common in this host order...
January 2, 2018: Virology
https://www.readbyqxmd.com/read/29300410/a-critical-assessment-of-the-environmental-fate-of-linear-and-cyclic-volatile-methylsiloxanes-using-multimedia-fugacity-models
#4
Dimitri Panagopoulos, Matthew MacLeod
We apply multimedia models to systematically evaluate the fate profile of cyclic volatile methyl siloxanes (VMS) D4, D5 and D6, and the linear VMS L4 and L5 using recently reported measurements of their partition ratios between organic carbon and water (KOC), their salting out constants (Ks), and their enthalpy of sorption to organic carbon (ΔHOC). Our assessment follows a multi-stage strategy where the environmental fate of the chemicals is explored in generic regional models with increasing fidelity to the real system and in a region-specific model...
January 4, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29289835/antinociceptive-anti-inflammatory-and-toxicological-evaluation-of-semi-synthetic-molecules-obtained-from-a-benzyl-isothiocyanate-isolated-from-moringa-oleifera-lam-in-a-temporomandibular-joint-inflammatory-hypernociception-model-in-rats
#5
Alain Oliveira Dos Santos, Danielle Rocha do Val, Felipe Dantas da Silveira, Francisco Isaac Fernandes Gomes, Hermany Capistrano Freitas, Ellen Lima de Assis, Diana Kelly Castro de Almeida, Igor Iuco Castro da Silva, Francisco Geraldo Barbosa, Jair Mafezoli, Marcos Reinaldo da Silva, Gerly Anne de Castro Brito, Juliana Trindade Clemente-Napimoga, Vicente de Paulo Teixeira de Paulo Teixera Pinto, Gerardo Cristino Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves
Inflammation is a key component of many clinical conditions that affect the temporomandibular joint (TMJ) and Moringa oleifera Lam. has been used to treat inflammatory diseases. Here, we evaluated the toxicological effects on mice of a naturally-occurring isothiocyanate from M. oleifera and its seven analogue molecules. Further, the anti-nociceptive and anti-inflammatory effects on a rat model of TMJ inflammatory hypernociception were assessed. The systemic toxicological profile was determined in mice over a 14-day period: MC-1 1 μg/kg; MC-D1 1 μg/kg, MC-D3 100 μg/kg, MC-D6 1 μg/kg, MC-D7 1 μg/kg, MC-D8 1 μg/kg, MC-D9 10 μg/kg, and MC-H 1 μg/kg...
December 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29288965/determination-of-total-plasma-oxysterols-by-enzymatic-hydrolysis-solid-phase-extraction-and-liquid-chromatography-coupled-to-mass-spectrometry
#6
Isabel Mendiara, Celia Domeño, Cristina Nerín, Aron M Geurts, Jesús Osada, Roberto Martínez-Beamonte
The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme-Pseudomonas and bovine pancreas, presence of surfactants, incubation time and amount of enzyme. Free forms of 4β-, 7-, 24-, 25- and 27-hydroxycholesterol (HC) as well 7-ketocholesterol (7-KC) were analyzed by liquid chromatography and mass-spectrometry using the deuterated internal standard, 25-HC(d6). Enzymatic hydrolysis was more effective using the Pseudomonas enzyme and in presence of surfactants...
December 21, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29278688/stage-specific-metabolic-features-of-differentiating-neurons-implications-for-toxicant-sensitivity
#7
Johannes Delp, Simon Gutbier, Martin Cerff, Christin Zasada, Sebastian Niedenführ, Liang Zhao, Lena Smirnova, Thomas Hartung, Hanna Borlinghaus, Falk Schreiber, Jörg Bergemann, Jochem Gätgens, Martin Beyss, Salah Azzouzi, Tanja Waldmann, Stefan Kempa, Katharina Nöh, Marcel Leist
Developmental neurotoxicity (DNT) may be induced when chemicals disturb a key neurodevelopmental process, and many tests focus on this type of toxicity. Alternatively, DNT may occur when chemicals are cytotoxic only during a specific neurodevelopmental stage. The toxicant sensitivity is affected by the expression of toxicant targets and by resilience factors. Although cellular metabolism plays an important role, little is known how it changes during human neurogenesis, and how potential alterations affect toxicant sensitivity of mature vs...
December 24, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29260150/a-square-planar-gold-iii-bis-1-1-dimethyl-3-3-methylene-diimidazol-2-2-diylidene-trication-as-an-efficient-and-selective-receptor-towards-halogen-anions-the-cooperative-effect-of-aux-and-xhc-interactions
#8
Marco Baron, Anna Dall'Anese, Cristina Tubaro, Laura Orian, Valerio Di Marco, Sara Bogialli, Claudia Graiff, Marino Basato
Treatment of the tricationic gold(iii) [Au(MeImCH2ImMe)2](PF6)3 complex 1-3PF6 (Im = imidazol-2-ylidene) with excess halides affords complexes 1-3X (X = Cl, Br, and I), resulting from counter anion PF6-/X- exchange. The 1H chemical shift of the CH3 groups and particularly that of the CH2 linker in DMSO-d6 are different in the three complexes, thus suggesting selective XHC interactions. Complex 13+ can therefore be used as a halide sensor in DMSO and water. The host-guest interaction between the tricationic gold(iii) complex and the halides Cl-, Br- and I- in solution and in the solid state has been investigated by means of NMR titration experiments, DFT calculations and X-ray structure analysis...
December 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29223074/bioaccumulation-and-trophic-transfer-of-cyclic-volatile-methylsiloxanes-cvms-in-the-aquatic-marine-food-webs-of-the-oslofjord-norway
#9
David E Powell, Merete Schøyen, Sigurd Øxnevad, Reinhard Gerhards, Thomas Böhmer, Martin Koerner, Jeremy Durham, Darren W Huff
The trophic transfer of cyclic methylsiloxanes (cVMS) in aquatic ecosystems is an important criterion for assessing bioaccumulation and ecological risk. Bioaccumulation and trophic transfer of cVMS, specifically octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6), were evaluated for the marine food webs of the Inner and Outer Oslofjord, Norway. The sampled food webs included zooplankton, benthic macroinvertebrates, shellfish, and finfish species. Zooplankton, benthic macroinvertebrates, and shellfish occupied the lowest trophic levels (TL ≈2 to 3); northern shrimp (Pandalus borealis) and Atlantic herring (Clupea harengus) occupied the middle trophic levels (TL ≈3 to 4), and Atlantic cod (Gadus morhua) occupied the highest tropic level (TL>4...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29218637/specific-phosphorothioate-substitution-within-domain-6-of-a-group-ii-intron-ribozyme-leads-to-changes-in-local-structure-and-metal-ion-binding
#10
Michèle C Erat, Emina Besic, Michael Oberhuber, Silke Johannsen, Roland K O Sigel
Group II introns are large self-splicing ribozymes that require high amounts of monovalent and divalent metal ions for folding and catalysis under in vitro conditions. Domain 6 of these ribozymes contains a highly conserved adenosine whose 2'-OH acts as a nucleophile during self-cleavage via the branching pathway. We have previously suggested a divalent metal ion that binds to the major groove at the GU wobble pair above the branch-A in a minimal, but active branch domain construct (D6-27) from the yeast mitochondrial intron Sc...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29210406/a-hydrogen-atom-transfer-mechanism-in-the-oxidation-of-alcohols-by-feo4-2-in-aqueous-solution
#11
Jianhui Xie, Po-Kam Lo, Chow-Shing Lam, Kai-Chung Lau, Tai-Chu Lau
The ferrate(vi) ion, [FeO4]2-, has attracted much interest in recent years because of its potential use as a green oxidant in organic synthesis and water treatment. Although there have been several reports on the use of ferrate(vi) for the oxidation of alcohols to the corresponding carbonyl compounds, the mechanism remains unclear. In this work, the kinetics of the oxidation of a series of alcohols with α-C-H bond dissociation energies ranging from 81 to 95 kcal mol-1 have been studied by UV/Vis spectrophotometry...
December 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29198030/adsorptive-performance-of-coal-based-magnetic-activated-carbon-for-cyclic-volatile-methylsiloxanes-from-landfill-leachate
#12
Chunhui Zhang, Shan Jiang, Wenwen Zhang
Bituminous coal-based magnetic activated carbon (MAC) was prepared, characterized, and used successfully for removal of cyclic volatile methylsiloxanes (cVMSs) from treated landfill leachate. Batch adsorption studies were performed at different adsorption dosages and contact times. With adsorptive dosage of 0.75 g/L and contact time of 60 min, the removal efficiencies achieved by MAC for octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6) are 100, 82...
December 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29197724/follicular-response-and-oocyte-production-following-variations-in-ovarian-stimulation-in-goats
#13
Claudinéia Silva Mendes, Larissa Pires Barbosa, Monna Lopes de Araújo, Emmanuel Emydio Gomes Pinheiro, Maicon Pereira Lents, Lincoln da Silva Amorim, Cláudia Kazumi Kiya, Ana Lúcia Almeida Santana
In this study, goats were subjected to ovarian stimulation protocols to evaluate possible differences in ovarian follicular responses and oocyte production. Two experiments were conducted to assess the effects of hormonal protocol duration (seven or twelve days) and number of follicle stimulating hormone (FSH) applications (one or five doses). All animals received intravaginal sponges saturated with 60 mg medroxyprogesterone acetate and an application of 125 μg cloprostenol 72 h before the sponges were removed...
November 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/29187651/-comparison-of-effects-between-il-2-and-il-7-on-glutamic-acid-decarboxylase-65-reactive-t-cell-responses-in-patients-with-type-1-diabetes
#14
Jiao Yuan, Qiuyan Cui, Wei Tang, Chen Chao, Zhiguang Zhou, Lin Yang
To explore the type of cytokine (IL-2 or IL-7) and its most optimal concentration regarding the improvement of the signal-to-noise ratio of glutamic acid decarboxylase 65 (GAD65) in enzyme-linked immunospot (ELISPOT) assay in Type 1 diabetic (T1DM) patients.
 Methods: Twenty T1DM patients (Group A) and sixteen healthy controls matched with age and sex (Group B) were enrolled in our study, and their peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll method. GAD65, internal control and Pediacel served as "five-for-one" vaccine were selected as the stimulating antigen...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29181224/application-of-19f-nmr-spectroscopy-for-content-determination-of-fluorinated-pharmaceuticals
#15
Alex O Okaru, Tobias S Brunner, Svenja M Ackermann, Thomas Kuballa, Stephan G Walch, Matthias Kohl-Himmelseher, Dirk W Lachenmeier
A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. 19F NMR spectra were either obtained in dimethylsulfoxide-d6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method. The method was found to be fit for purpose (interday precision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing pharmaceuticals due to its simplicity, nondestructive sample measurement, reliability, and high specificity...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29179541/1h-nmr-relaxometry-and-diffusometry-study-of-magnetic-and-non-magnetic-ionic-liquid-based-solutions-co-solvent-and-temperature-effects
#16
Maria Jardim Beira, Carla I Daniel, Pedro L Almeida, Marta C Corvo, Andreia A Rosatella, Carlos A M Afonso, Pedro J Sebastiao
In this work, 1H NMR relaxometry and diffusometry as well as viscometry experiments were carried out as a means to study the molecular dynamics of magnetic and non-magnetic ionic liquid-based systems. In order to evaluate the effect of a co-solvent on the super-paramagnetic properties observed for Aliquat-iron-based magnetic ionic liquids, mixtures comprising different concentrations, 1% and 10% (v/v), of DMSO-d6 were prepared and analyzed. The results suggest that, when at low concentrations, DMSO-d6 promotes more structured ionic arrangements, thus enhancing these super-paramagnetic properties...
November 27, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29179531/solvation-of-amides-in-dmso-and-cdcl3-an-attempt-at-quantitative-dft-based-interpretation-of-1h-and-13c-nmr-chemical-shifts
#17
Sergey Molchanov, Adam Gryff-Keller
The study concerns N-methyl-2-pyrrolidinone, DMF, 2-pyrrolidinone, N-methylformamide and formamide in DMSO-d6 and CDCl3 solutions. It has been shown that the results of DFT calculations [B3LYP and/or PBE0 6-311++G(2d,p), PCM] of molecular geometries and magnetic shielding are able to reproduce very well the amide 1H NMR and 13C NMR chemical shifts measured in these solvents provided that the specific solvation of the solute molecules and their association are taken into account and also that comparison of the experimental and theoretical data is carefully done...
November 27, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29170774/a-modular-approach-towards-functionalized-highly-stable-self-complementary-quadruple-hydrogen-bonded-systems
#18
Suresh Rayavarapu, Sanjeev Kheria, Dinesh R Shinde, Rajesh G Gonnade, Gangadhar J Sanjayan
Self-complementary quadruple hydrogen bonded systems have shown potential as key building blocks for developing various supramolecular polymers. Opportunities for the introduction of multiple functionalities would further augment, in principle, their application potential. Herein, we report a novel modular approach to simultaneously introduce two closely aligned side chains into AADD-type self-complementary quadruple hydrogen-bonding systems. Dithiane-tethered ureidopyrimidinone has been used as a reactive intermediate to efficiently attach closely aligned side chains by simply reacting with amines to form highly stable molecular duplexes...
November 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29151385/the-compositional-and-metabolic-responses-of-gilthead-seabream-sparus-aurata-to-a-gradient-of-dietary-fish-oil-and-associated-n-3-long-chain-pufa-content
#19
Sam J S Houston, Vasileios Karalazos, John Tinsley, Mónica B Betancor, Samuel A M Martin, Douglas R Tocher, Oscar Monroig
The replacement of fish oil (FO) with vegetable oil (VO) in feed formulations reduces the availability of n-3 long-chain PUFA (LC-PUFA) to marine fish such as gilthead seabream. The aim of this study was to examine compositional and physiological responses to a dietary gradient of n-3 LC-PUFA. Six iso-energetic and iso-nitrogenous diets (D1-D6) were fed to seabream, with the added oil being a blend of FO and VO to achieve a dietary gradient of n-3 LC-PUFA. Fish were sampled after 4 months feeding, to determine biochemical composition, tissue fatty acid concentrations and lipid metabolic gene expression...
November 20, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29131932/redox-dependent-metal-metal-bonding-in-trinuclear-metal-chains-probing-the-transition-from-covalent-bonding-to-exchange-coupling
#20
John Ewart McGrady, Nicholas Perkins, Mohammed Obies, Graham Heath, Alison Edwards, Vaida Arcisauskaite
We report here the synthesis and physical properties of two new cationic tri-metallic chains, [(PEt3)3RuCl3M'Cl3Ru(PEt3)3]1+, M' = Rh and Ir. These are isostructural with a previously reported 17-electron all-ruthenium analogue, but the switch from an open-shell d5 Ru3+ ion to d6 Rh3+/Ir3+ in the central position has profound impact on the nature of the metal-metal bonding. X-ray crystallography and spectro-electrochemistry, complemented by electronic structure analysis at the DFT and CASSCF levels, indicate that whilst the presence of a Ru3+ ion in the center of the chain allows multi-center covalent bonding to develop, a closed-shell Rh3+/Ir3+ ion pushes the system towards the exchange-coupled limit, where the terminal Ru centers are only weakly interacting...
November 13, 2017: Chemistry: a European Journal
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