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https://www.readbyqxmd.com/read/28537407/8-propyldithieno-3-2-b-2-3-e-pyridine-3-5-diamine-ditipiram-derivatives-as-neutral-receptors-tailored-for-binding-of-carboxylates
#1
Agnieszka Cholewiak, Agnieszka Tycz, Janusz Jurczak
The DITIPIRAM (8-propyldithieno[3,2-b:2',3'-e]pyridine-3,5-diamine)-based receptors 11 and 12 were readily synthesized, and their anion-binding properties were studied both in solution and in the solid-state. (1)H NMR titrations revealed that receptor 12 equipped with two phenyl-urea groups preferentially binds carboxylates, even in the highly competitive DMSO-d6/CD3OH solvent mixture. X-ray analysis showed that receptor 12 exhibited great complementarity for benzoate, which is cooperatively bound by the means of four highly directional hydrogen bonds from the two urea groups...
May 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/28534606/standardized-reporting-of-functioning-information-on-icf-based-common-metrics
#2
Birgit Prodinger, Alan Tennant, Gerold Stucki
BACKGROUND: In clinical practice and research a variety of clinical data collection tools are used to collect information on people's functioning for clinical practise and research and National Health Information Systems. Reporting on ICF-based common metrics enables standardized documentation of functioning information in national health information systems. OBJECTIVE: The objective of this methodological note on applying the ICF in rehabilitation is to demonstrate how to report functioning information collected with a data collection tool on ICF-based common metrics...
May 23, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28528213/optimal-electrostatic-interactions-between-substrate-and-protein-are-essential-for-radical-chemistry-in-ornithine-4-5-aminomutase
#3
Caitlyn Makins, Douglas A Whitelaw, Michael McGregor, Alix Petit, Robert G Mothersole, Kathleen E Prosser, Kirsten R Wolthers
Ornithine 4,5-aminomutase (OAM) from Clostridium sticklandii is an adenosylcobalamin (AdoCbl) and pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes a 1,2-amino shift, interconverting D-ornithine and 2S, 4R-diaminopentanoate. The reaction occurs via a radical-based mechanism whereby a PLP-bound substrate radical undergoes intramolecular isomerization via an azacyclopropylcarbinyl radical intermediate. Herein, we investigated the catalytic role of active site residues that form non-covalent interactions with PLP and/or substrate, D-ornithine...
May 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28527768/randomized-comparison-of-absorb-bioresorbable-vascular-scaffold-and-mirage-microfiber-sirolimus-eluting-scaffold-using-multimodality-imaging
#4
Erhan Tenekecioglu, Patrick W Serruys, Yoshinobu Onuma, Ricardo Costa, Daniel Chamié, Yohei Sotomi, Ting-Bin Yu, Alexander Abizaid, Houng-Bang Liew, Teguh Santoso
OBJECTIVES: The primary objective of this study was to evaluate the safety and effectiveness of the Mirage bioresorbable microfiber sirolimus-eluting scaffold compared with the Absorb bioresorbable vascular scaffold in the treatment of stenotic target lesions located in native coronary arteries, ranging from ≥2.25 to ≤4.0 mm in diameter. Secondary objectives were to establish the medium-term safety, effectiveness, and performance of the Mirage device. BACKGROUND: The current generation of bioresorbable scaffolds has several limitations, such as thick square struts with large footprints that preclude their deep embedment into the vessel wall, resulting in protrusion into the lumen with microdisturbance of flow...
May 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28521812/radiotherapy-improves-serum-fatty-acids-and-lipid-profile-in-breast-cancer
#5
Sana Shaikh, Naseem Aslam Channa, Farha Naz Talpur, Muhammad Younis, Naila Tabassum
BACKGROUND: Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer. METHODS: In this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile...
May 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28521250/development-and-validation-of-lc-ms-ms-methods-for-the-measurement-of-ribociclib-a-cdk4-6-inhibitor-in-mouse-plasma-and-ringer-s-solution-and-its-application-to-a-cerebral-microdialysis-study
#6
Ashish Kala, Yogesh T Patel, Abigail Davis, Clinton F Stewart
LC-MS/MS methods to measure ribociclib in mouse plasma and Ringer's solution were successfully developed and validated. Reverse phase chromatography was performed with gradient elution using C18 (100A, 50×4.6mm, 3μ) and C8-A (50×2.0mm, 5μ) columns for plasma and Ringer's samples, respectively. Mouse plasma samples were extracted using solid phase extraction method, whereas no extraction was required for the Ringer's solution samples. Analytes were detected using positive ion MRM mode. The precursor to product ions (Q1→Q3) selected for ribociclib and d6-ribociclib were (m/z) 435...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28511917/evidence-of-the-role-of-the-vagal-nerves-as-a-monitor-in-the-gastrointestinal-renal-axis-of-natriuresis-in-human-effects-of-vagotomy
#7
Constantinos E Alifieris, Dimitrios T Trafalis, Aris D Efstratopoulos, Emmanuel K Alifieris
This study aimed to investigate the mechanism of gastrointestinal regulation of natriuresis. Sixteen subjects without (group I) and sixteen subjects with a truncal vagotomy (group II), were given a daily diet of 18mmol of sodium for 5days (D1-D5). The sodium deficit for this period was calculated for each subject and on the morning of day-6 (D6), their cumulative deficit (E) was given as 3% NaCl. In both groups the subjects were divided to receive the hypertonic saline either orally (Ior, IIor) or intravenously (Iiv, IIiv)...
May 10, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28502731/the-influence-of-a-probiotic-supplementation-on-memory-in-quail-suggests-a-role-of-gut-microbiota-on-cognitive-abilities-in-birds
#8
Severine Parois, Ludovic Calandreau, Narjis Kraimi, Irène Gabriel, Christine Leterrier
The gut microbiota is involved in host behaviour and memory in mammals. Consequently, it may also influence emotional behaviour and memory in birds. Quail from two genetic lines with different fearfulness (LTI: long tonic immobility, n=37; STI: short tonic immobility, n=32) were either or not supplemented with a probiotic (Pediococcus acidilactici) from hatching. Emotional reactivity was measured in a tonic immobility test (d6 and 7 of age) and two open-field tests (d13 to 15; d22 to 24). Memory was measured in a test rewarded with mealworms, where quail had to remember the cups previously visited (d34 to 36)...
May 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28494354/development-of-collection-storage-and-analysis-procedures-for-the-quantification-of-cyclic-volatile-methylsiloxanes-in-wastewater-treatment-plant-effluent-and-influent
#9
Scott M Knoerr, Jeremy A Durham, Debra A McNett
A reliable and accurate method for collection and analysis of octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6) in wastewater treatment plant influent, effluent and surface waters was developed. Due to the use of cyclic volatile methylsiloxanes (cVMS) in industrial and consumer products including some personal care products, the wastewater stream represents a potential post-use disposal route and cVMS may subsequently enter the environment through wastewater treatment plant effluents...
May 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28492733/simultaneous-determination-of-furan-and-vinyl-acetate-in-vapor-phase-of-mainstream-cigarette-smoke-by-gc-ms
#10
Aifei Xu, Zhong Fan, Zhiyan Chen, Yun Zhou, Shaohua Liu, Shijie Huang, Xuequin Xu, Congyun Long, Weigang Wang, Jing Zhu, Xiaolan Li, Chunping Xu
A simple and sensitive method for simultaneous determination of furan and vinyl acetate (VA) in vapor phase of mainstream cigarette smoke with cold trap and gas chromatography-mass spectrometry (GC-MS) was developed. A Cambridge filter pad (CFP) was placed in front of the impingers of smoking machine to remove the particle phase from cigarette smoke. Furan and VA in vapor phase of mainstream cigarette smoke were collected in two impingers connected in series by filled with methanol at -78°C. The solutions were added with deuterium-labeled furan-d4 and VA-d6 as internal standards and analyzed by GC-MS...
May 4, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28490031/a-systematic-review-of-the-clinimetric-properties-of-the-6-item-version-of-the-hamilton-depression-rating-scale-ham-d6
#11
N Timmerby, J H Andersen, S Søndergaard, S D Østergaard, Per Bech
BACKGROUND: In a study aimed at identifying the items carrying information regarding the global severity of depression, the 6-item Hamilton Depression Rating Scale (HAM-D6) was derived from the original 17-item version of the scale (HAM-D17). Since then, the HAM-D6 has been used in a wide range of clinical studies. We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale (MADRS). METHODS: We conducted a systematic search of the literature in PubMed, PsycInfo, and EMBASE databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28485592/analysis-of-prepeak-structure-of-concentrated-organic-lithium-electrolyte-by-means-of-neutron-diffraction-with-isotopic-substitution-and-molecular-dynamics-simulation
#12
Tsuyoshi Yamaguchi, Koji Yoshida, Toshio Yamaguchi, Yasuo Kameda, Kazutaka Ikeda, Toshiya Otomo
The prepeak structure of a 3 mol / kg solution of LiClO4 in propylene carbonate (PC) was studied by both neutron diffraction with isotopic substitution (NDIS) and molecular dynamics (MD) simulation. The NDIS data showed that the intensity of the prepeak decreases experimentally with increasing the scattering length of the lithium atom from (7)Li to (6)Li in PC-d6. On the other hand, although the prepeak was observed in solutions of both PC-d6 and PC-h6, it disappears when the 1:1 mixture of PC-d6 and PC-h6 was used as the solvent...
May 9, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28477143/association-between-mrna-expression-of-cd74-and-il10-and-risk-of-icu-acquired-infections-a-multicenter-cohort-study
#13
Estelle Peronnet, Fabienne Venet, Delphine Maucort-Boulch, Arnaud Friggeri, Martin Cour, Laurent Argaud, Bernard Allaouchiche, Bernard Floccard, Frédéric Aubrun, Thomas Rimmelé, Fabrice Thiolliere, Vincent Piriou, Julien Bohé, Marie-Angélique Cazalis, Véronique Barbalat, Guillaume Monneret, Stéphane Morisset, Julien Textoris, Hélène Vallin, Alexandre Pachot, Alain Lepape
PURPOSE: Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs and mortality. To date, no biomarker has shown sufficient evidence and ease of application in clinical routine for the identification of patients at risk of IAI. We evaluated the association of the systemic mRNA expression of two host response biomarkers, CD74 and IL10, with IAI occurrence in a large cohort of ICU patients. METHODS: ICU patients were prospectively enrolled in a multicenter cohort study...
May 5, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28470512/suppressive-effect-of-microrna319-expression-on-rice-plant-height
#14
Wei-Ting Liu, Peng-Wen Chen, Li-Chi Chen, Chia-Chun Yang, Shu-Yun Chen, GuanFu Huang, Tzu Che Lin, Hsin-Mei Ku, Jeremy J W Chen
KEY MESSAGE: miR319 was identified as a dwarf-inducing gene from Shiokari and its dwarf near isogenic line, and its transgenic rice showed a reduced plant height. This finding reveals the potential application of miR319 in future molecular breeding. It is well known that microRNAs (miRNAs) play important roles in plant physiology, especially in development and stress responses. However, little is known about the role of miRNAs in plant height. In this study, the rice cultivar Shiokari and its dwarf near isogenic line Shiokari-d6 were analysed to identify and characterize plant height-associated miRNAs...
May 3, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28446036/fusaripeptide-a-new-antifungal-and-anti-malarial-cyclodepsipeptide-from-the-endophytic-fungus-fusarium-sp
#15
Sabrin R M Ibrahim, Hossam M Abdallah, Ehab S Elkhayat, Nawal M Al Musayeib, Hani Z Asfour, Mohamed F Zayed, Gamal A Mohamed
From the culture of the endophytic fungus Fusarium sp. isolated from the roots of Mentha longifolia L. (Labiatae) growing in Saudi Arabia, a new cyclodepsipeptide, namely fusaripeptide A (1), along with three known compounds adenosine (2), 2[(2-hydroxypropionyl)amino]benzamide (3), and cyclopentanol (4), have been isolated. Their structures were determined, using extensive 1D and 2D NMR and HRESI and GC mass spectral data. That is the first report for the isolation of compound 4 from natural source. In addition, compounds 2 and 3 are reported here for the first time from Fusarium sp...
April 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28433034/direct-1-h-nmr-evidence-of-spin-rotation-coupling-as-a-source-of-para-%C3%A2-ortho-h2-conversion-in-diamagnetic-solvents
#16
Camilla Terenzi, Sabine Bouguet-Bonnet, Daniel Canet
At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2. When p-H2 is dissolved in a diamagnetic organic solvent, conversion is very slow and can be considered as arising from nuclear spin relaxation phenomena. A first relaxation mechanism, specific to the singlet state and involving a combination of auto-correlation and cross correlation spectral densities, can be retained: randomly fluctuating magnetic fields due to inter-molecular dipolar interactions...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28431176/effect-of-melatonin-on-renewal-of-chicken-small-intestinal-mucosa
#17
J Li, R X Li, G Liu, C F Lv, Y L Mi, C Q Zhang
A higher concentration of melatonin (MEL) in the intestine - even more than that in the plasma and pineal gland - implies its putative important role in the gastrointestinal structural or functional regulation. However, little evidence has shown that MEL can regulate the physiological functions of the intestinal mucosa. In this study, fertilized chicken eggs were treated with MEL (0.1 to 10 μg/d) from embryonic d 12 (E12) to post-hatching d 6 (D6), and the small intestine samples were collected at D6 to determine the changes in mucosal construction and function...
April 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28418624/nickel-cornered-molecular-rectangles-as-polycyclic-aromatic-hydrocarbon-receptors
#18
Víctor Martínez-Agramunt, Sheila Ruiz-Botella, Eduardo Peris
Two nickel-cornered organometallic metalla-rectangles containing a pyrene-linked-di-N-heterocyclic carbene have been prepared. The dimensions of one side of the rectangle were modulated by either using pyrazine or 4,4'-bipyridine. The two molecules were tested as hosts for the recognition of seven small polycyclic aromatic hydrocarbons (PAHs) in [D6 ]acetone. By using (1) H NMR spectroscopy titrations, it could be established that the host-guest stoichiometries of the inclusion complexes formed were 1:1 for the pyrazine-based host, and 1:2 for the host containing bipyridine, in accordance with the larger dimensions of the latter...
May 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28402639/a-simple-approach-for-predicting-the-spin-state-of-homoleptic-fe-ii-tris-diimine-complexes
#19
Hoa Phan, Jeremy J Hrudka, Dilyara Igimbayeva, Latévi M Lawson Daku, Michael Shatruk
We propose a simple method for predicting the spin state of homoleptic complexes of the Fe(II) d(6) ion with chelating diimine ligands. The approach is based on the analysis of a single metric parameter within a free (noncoordinated) ligand: the interatomic separation between the N-donor metal-binding sites. An extensive analysis of existing complexes allows the determination of critical N···N distances that dictate the regions of stability for the high-spin and low-spin complexes, as well as the intermediate range in which the magnetic bistability (spin crossover) can be observed...
April 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28395348/exposure-assessment-in-a-single-walled-carbon-nanotube-primary-manufacturer
#20
Serge Kouassi, Cyril Catto, Claude Ostiguy, Gilles L'Espérance, Jens Kroeger, Maximilien Debia
Objectives: This study was aimed at documenting and characterizing occupational exposure to single-walled carbon nanotubes (SWCNTs) generated in a primary manufacturing plant. It also compared various strategies of exposure monitoring. Methods: A 6-day measurement protocol was scheduled (D1-D6) including both (i) quasi-personal monitoring with an array of direct reading instruments (DRIs) and (ii) offline electron microscopy analyses of surface and breathing zone filter-based samples...
March 1, 2017: Annals of Work Exposures and Health
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