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https://www.readbyqxmd.com/read/29454302/aerobic-exercise-inhibits-obesity-induced-respiratory-phenotype
#1
Jefferson Comin Jonco Aquino-Junior, BreAnne MacKenzie, Ana Roberta Almeida-Oliveira, Ana Carolina Martins, Manoel Carneiro Oliveira-Junior, Auriléa Aparecida Britto, Fernanda Magalhaes Arantes-Costa, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Ligeiro de Oliveira, Dioze Guadagnini, Luiz Osorio Leiria, Djalma Rabelo Ricardo, Mario Jose Abdalla Saad, Rodolfo Paula Vieira
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15)...
February 14, 2018: Cytokine
https://www.readbyqxmd.com/read/29453669/physical-training-and-cardiac-rehabilitation-in-heart-failure-patients
#2
Cesare de Gregorio
Regardless of advances in medical and interventional treatment of cardiovascular disease (CVD), a limited number of patients attend a cardiac rehabilitation (CR) programme on a regular basis. Due to modern therapies more individuals will be surviving an acute cardiovascular event, but the expected burden of chronic heart failure will be increasing worldwide.However, both in high- and low-income countries, secondary prevention after an acute myocardial infarction or stroke has been implemented in less than a half of eligible patients...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453139/effect-of-inhaled-corticosteroids-on-lung-function-in-chronic-beryllium-disease
#3
Margaret M Mroz, John H Ferguson, Anna V Faino, Annyce Mayer, Matthew Strand, Lisa A Maier
BACKGROUND: The clinical effects of inhaled corticosteroids (ICS) on chronic beryllium disease (CBD) are unknown. Although frequently used for symptoms or disease not requiring systemic therapy, the clinical course of patients on ICS has not been evaluated. METHODS: In a retrospective cohort study, forty-eight subjects with CBD, diagnosed by granulomas on lung biopsy and treated with inhaled corticosteroids, were matched to sixty-eight subjects with CBD who were not treated...
February 5, 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29452690/utility-of-physician-selection-of-cardiac-tests-in-a-chest-pain-unit-to-exclude-acute-coronary-syndrome-among-patients-without-a-history-of-coronary-artery-disease
#4
Stacey J Howell, Jonathan Bui, Balasingam Thevakumar, Ezra A Amsterdam
There are few data on the utility of physician selection of cardiac tests, including no-test, in a chest pain unit (CPU) to rule out acute coronary syndrome in low-risk patients without a history of coronary artery disease. We analyzed consecutive low-risk patients admitted to our CPU between 2012 and 2014 and determined the proportion of patients selected for testing, the type of initial cardiac test selected, and the incidence of major adverse cardiac events (MACEs) at 30 days and 6 months. The study group comprised 619 patients: mean age 57 years (27 to 92), 332 women (54%), and 360 (58%) with multiple cardiac risk factors...
January 10, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29452626/translation-of-an-evidence-based-therapeutic-exercise-program-for-patients-with-peripheral-artery-disease
#5
Dereck L Salisbury, Mary O Whipple, Marsha Burt, Rebecca J L Brown, Alan Hirsch, Christopher Foley, Diane Treat-Jacobson
The purpose of this study was to implement and evaluate quality outcomes including referral, enrollment, and completion rates of a new peripheral artery disease (PAD)-specific supervised exercise therapy (SET) program within a preexisting clinical exercise wellness program and to evaluate the clinical effectiveness and patient-centered outcomes derived from 12 weeks of PAD-specific SET. Recruited participants completed an individualized, minimally supervised, PAD-specific SET program based on the AHA-ACC guidelines...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29452135/evidence-based-exercise-recommendations-to-reduce-hepatic-fat-content-in-youth-a-systematic-review-and-meta-analysis
#6
REVIEW
María Medrano, Cristina Cadenas-Sanchez, Celia Álvarez-Bueno, Iván Cavero-Redondo, Jonatan R Ruiz, Francisco B Ortega, Idoia Labayen
The main purposes of this study were to elucidate the effects of supervised-exercise training (ET) interventions on hepatic fat content and on non-alcoholic fatty liver disease (NAFLD) prevalence in children and adolescents and to provide information about the optimal ET prescription (type, intensity, volume, and frequency) needed to reduce hepatic fat content in youths. Supervised-ET interventions performed in children and adolescents (6-19 years) that provided results of exercise effects on hepatic fat content or NAFLD prevalence were included...
February 13, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29451666/pilates-for-breast-cancer-a-systematic-review-and-meta-analysis
#7
Roberta Costa Espíndula, Gabriella Barbosa Nadas, Maria Inês da Rosa, Charlie Foster, Florentino Cardoso de Araújo, Antonio Jose Grande
INTRODUCTION: Breast cancer is the leading type of cancer causing death in women worldwide. The incidence of the disease is expected to grow worldwide due to the aging of the population and risk factors related to lifestyle behaviors. Considering the lifestyle of women with breast cancer before or after surgery, pilates exercise may be a complementary intervention additionally to standard treatment. OBJECTIVE: To analyze the efficacy of pilates compared to other exercises and to no exercise for women with breast cancer diagnosis...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451419/physical-exercise-nutrition-and-hormones-three-pillars-to-fight-sarcopenia
#8
Paolo Sgrò, Massimiliano Sansone, Andrea Sansone, Stefania Sabatini, Paolo Borrione, Francesco Romanelli, Luigi Di Luigi
BACKGROUND: Sarcopenia is a pathophysiological condition diffused in elderly people; it represents a social issue due to the longer life expectancy and the growing aging population. It affects negatively quality of life and it represents a risk factor for other pathologies, such as diabetes, cardiovascular disease, and obesity. No silver bullet exists to hinder sarcopenia, but it may be counteracted by physical exercise, nutrition, and a proper endocrine milieu. Indeed, we aim to analyze the scientific literature to give to clinician effective advices to counteract sarcopenia...
February 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29451072/social-support-for-exercise-as-a-predictor-of-weight-and-physical-activity-status-among-puerto-rican-and-mexican-men-results-from-the-latino-men-s-health-initiative
#9
Meredith R Craven, Laurie Keefer, Alfred Rademaker, Amanda Dykema-Engblade, Lisa Sanchez-Johnsen
Social support is an important factor in increasing positive health outcomes and positive health behaviors across a variety of disease states including obesity. However, research examining the relationship between social support for exercise and weight and physical activity status, particularly among Latino men, is lacking. This paper examined whether social support for exercise predicted weight and physical activity status and whether the direction of these relationships differ as a function of Hispanic/Latino background (Puerto Rican/Mexican)...
February 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29450659/social-factors-in-the-development-of-chronic-rhinosinusitis-a-systematic-review
#10
REVIEW
I Geramas, D Terzakis, E Hatzimanolis, C Georgalas
PURPOSE OF REVIEW: In an era where prevention is paramount, understanding social factors for chronic rhinosinusitis (CRS) may facilitate preventive interventions that mitigate risk factors associated with the initiation or progression of the disease. RECENT FINDINGS: Both passive and active smoking are clearly and unequivocally associated with both the incidence and the severity of rhinosinusitis, while there an increasing body of evidence linking social deprivation and low socioeconomic status with rhinosinusitis and its complications...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29450605/abbreviated-mpmri-protocol-for-diffuse-liver-disease-a-practical-approach-for-evaluation-and-follow-up-of-nafld
#11
Guilherme Moura Cunha, Cristiane A Villela-Nogueira, Anke Bergman, Flavia Paiva Proença Lobo Lopes
AIM: Multiparametric magnetic resonance imaging (mpMRI) may help determine the metabolic profile of patients with obesity and metabolic syndrome in addition to their clinical and laboratory biomarkers for diagnosis and monitoring. An abbreviated mpMRI protocol may be a faster, less-costly, and easier to perform alternative for the diagnosis, treatment, and follow-up of patients with NAFLD and for use in clinical trials. OBJECTIVE: To evaluate an abbreviated mpMRI protocol tailored to analyze quantitative imaging features of patients with obesity and NAFLD and assess its use during treatment...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29450466/diagnostic-criteria-of-ulcerative-pyoderma-gangrenosum-a-delphi-consensus-of-international-experts
#12
Emanual Maverakis, Chelsea Ma, Kanade Shinkai, David Fiorentino, Jeffrey P Callen, Uwe Wollina, Angelo Valerio Marzano, Daniel Wallach, Kyoungmi Kim, Courtney Schadt, Anthony Ormerod, Maxwell A Fung, Andrea Steel, Forum Patel, Rosie Qin, Fiona Craig, Hywel C Williams, Frank Powell, Alexander Merleev, Michelle Y Cheng
Importance: Pyoderma gangrenosum is a rare inflammatory skin condition that is difficult to diagnose. Currently, it is a "diagnosis of exclusion," a definition not compatible with clinical decision making or inclusion for clinical trials. Objective: To propose and validate diagnostic criteria for ulcerative pyoderma gangrenosum. Evidence Review: Diagnostic criteria were created following a Delphi consensus exercise using the RAND/UCLA Appropriateness Method...
February 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29449201/peer-coaching-through-mhealth-targeting-physical-activity-in-people-with-parkinson-disease-feasibility-study
#13
Cristina Colón-Semenza, Nancy K Latham, Lisa M Quintiliani, Terry D Ellis
BACKGROUND: Long-term engagement in exercise and physical activity mitigates the progression of disability and increases quality of life in people with Parkinson disease (PD). Despite this, the vast majority of individuals with PD are sedentary. There is a critical need for a feasible, safe, acceptable, and effective method to assist those with PD to engage in active lifestyles. Peer coaching through mobile health (mHealth) may be a viable approach. OBJECTIVE: The purpose of this study was to develop a PD-specific peer coach training program and a remote peer-mentored walking program using mHealth technology with the goal of increasing physical activity in persons with PD...
February 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29447788/the-influence-of-febuxostat-on-coronary-artery-endothelial-dysfunction-in-patients-with-coronary-artery-disease-a-phase-4-randomized-placebo-controlled-double-blind-crossover-trial
#14
Allison G Hays, Micaela Iantorno, Michael Schär, Shenghan Lai, Matthew Czarny, Elayne Breton, Robert N Palmer, Andrew Whelton, Robert G Weiss, Gary Gerstenblith
BACKGROUND: The xanthine oxidase (XO) system is a significant source of vascular oxidative stress, which is believed to impair endothelial function, an important contributor to atherosclerotic disease. We tested whether febuxostat, a potent XO inhibitor, improves coronary endothelial function (CEF) in patients with stable coronary artery disease (CAD) in a single-center, randomized, placebo-controlled, double-blind crossover trial. METHODS: CEF was measured using noninvasive magnetic resonance imaging (MRI) assessment of changes in 30 patients with stable CAD and baseline impaired CEF...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447741/the-burden-of-iron-deficiency-in-heart-failure-therapeutic-approach
#15
REVIEW
Bruno M L Rocha, Gonçalo J L Cunha, Luiz F Menezes Falcão
Heart failure (HF) is highlighted by its burdening symptom-limited exercise capacity and recurrent hospitalizations. Despite substantial advances regarding disease-modifying drugs in HF with reduced ejection fraction, additional therapeutic strategies to improve quality of life are invaluable. Currently, iron deficiency (ID) is overwhelmingly recognized in over 30% to 50% of patients with stable chronic HF, which worsens prognosis. The established pathophysiological mechanisms of progressive HF may be intertwined with increasing myocardial iron scarcity, wherein one begets the other...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29446746/mechanisms-involved-in-glycemic-control-promoted-by-exercise-in-diabetics
#16
Eric Francelino Andrade, Viviam de Oliveira Silva, Debora Ribeiro Orlando, Luciano Jose Pereira
Diabetes mellitus is a metabolic disease characterized by high glycemic levels for long periods. This disease has a high prevalence in the world population, being currently observed an increase in its incidence. This fact is mainly due to the sedentary lifestyle and hypercaloric diets. Non-pharmacological interventions for glycemic control include exercise, which promotes changes in skeletal muscle and adipocytes. Thus, increased glucose uptake by skeletal muscle and decreased insulin resistance through modulating adipocytes are the main factors that improve glycemic control against diabetes...
February 14, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29445615/thermodynamic-effects-of-commercially-available-ice-boots
#17
Madison N Quintanar, Tess Pu'uwaionalani Millar, Matthew A Burd
The limb of the equine athlete is subjected to all types of various stressors during exercise. To ensure the health of the horse and to prevent the possibility of lameness, it has been a common practice to apply cold therapy to the distal limb of the horse pre- and post-exercise. Commercially available boots are widely available for the application of cold therapy. To test the effectiveness of the boot, 6 healthy performance level sport type horses were exercised at a walk, trot, and canter in a round-pen and then subjected to the application of the ice boot for 20 minutes on a treatment leg, and no ice boot on an untreated leg...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29445432/recurrent-intracerebral-hemorrhage-after-exercise-in-a-young-patient-presenting-with-sporadic-cerebral-amyloid-angiopathy-in-a-young-patient
#18
Muhammad Taimur Malik, Corey Myers, Syed Jaffar Kazmi, Ramin Zand
Cerebral Amyloid Angiopathy (CAA) is one of the significant causes of lobar intracerebral hemorrhage (ICH) mainly among elderly people. Sporadic cases of CAA have been linked to genetic polymorphisms with an increased risk of disease, an earlier presentation, and an accelerated pathology [1]. Here, we present a patient with no significant risk factors who had a recurrent intracerebral hemorrhage secondary to CAA probably induced by exercise.
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445271/immune-cell-response-to-strenuous-resistive-breathing-comparison-with-whole-body-exercise-and-the-effects-of-antioxidants
#19
Andreas Asimakos, Dimitrios Toumpanakis, Maria-Helena Karatza, Spyridoula Vasileiou, Paraskevi Katsaounou, Zafeiria Mastora, Theodoros Vassilakopoulos
Background/hypothesis: Whole body exercise (WBE) changes lymphocyte subset percentages in peripheral blood. Resistive breathing, a hallmark of diseases of airway obstruction, is a form of exercise for the inspiratory muscles. Strenuous muscle contractions induce oxidative stress that may mediate immune alterations following exercise. We hypothesized that inspiratory resistive breathing (IRB) alters peripheral blood lymphocyte subsets and that oxidative stress mediates lymphocyte subpopulation alterations following both WBE and IRB...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29445264/exercise-program-improved-subjective-dry-eye-symptoms-for-office-workers
#20
Kokoro Sano, Motoko Kawashima, Sayuri Takechi, Masaru Mimura, Kazuo Tsubota
Introduction: We investigated the benefits of a cognitive behavior therapy-based exercise program to reduce the dry eye symptoms of office workers. Materials and methods: We recruited 11 office workers with dry eye symptoms, aged 31-64 years, who voluntarily participated in group health guidance at a manufacturing company. Participants learned about the role of physical activity and exercise in enhancing wellness and performed an exercise program at home 3 days per week for 10 weeks...
2018: Clinical Ophthalmology
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