T E Darsaut, J M Findlay, M W Bojanowski, C Chalaala, D Iancu, D Roy, A Weill, W Boisseau, A Diouf, E Magro, M Kotowski, M B Keough, L Estrade, N Bricout, J-P Lejeune, M M C Chow, C J O'Kelly, J L Rempel, R A Ashforth, H Lesiuk, J Sinclair, U-E Erdenebold, J H Wong, F Scholtes, D Martin, B Otto, A Bilocq, E Truffer, K Butcher, A J Fox, A S Arthur, L Létourneau-Guillon, F Guilbert, M Chagnon, J Zehr, B Farzin, G Gevry, J Raymond
BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a randomized trial. MATERIALS AND METHODS: Clipping or endovascular treatments were randomly allocated to patients with one or more 3- to 25-mm unruptured intracranial aneurysms judged treatable both ways by participating physicians. The study hypothesized that clipping would decrease the incidence of treatment failure from 13% to 4%, a composite primary outcome defined as failure of aneurysm occlusion, intracranial hemorrhage during follow-up, or residual aneurysms at 1 year, as adjudicated by a core lab...
June 2023: AJNR. American Journal of Neuroradiology