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Ischemia reperfusion

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https://www.readbyqxmd.com/read/29163824/targeting-cyclophilin-d-by-compound-19-protects-neuronal-cells-from-oxygen-glucose-deprivation-re-oxygenation
#1
Jinyu Zheng, Enhui Cui, Haikou Yang, Mao Li, Jing Zhou, Ming Yan, Jian Sun, De-Rong Tang
Oxygen and glucose deprivation (OGD) with re-oxygenation (OGDR) is applied to neuronal cells to mimic ischemia-reperfusion injuries. Activation of cyclophilin D (Cyp-D)-dependent programmed necrosis pathway mediates OGDR-induced neuronal cell damages. Here, we tested the potential effect of Compound 19 (C19), a novel Cyp-D inhibitor, in this process. In both established neuronal cell lines (Neuro-2a and NB41A3 cells) and the primary murine CA1 hippocampal neurons, pretreatment with C19 largely attenuated OGDR-induced cell viability reduction and cell death...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163819/exploring-the-model-of-pc12-apoptosis-induced-by-ogsd-r-through-in-vitro-experiments
#2
Yanqing Sun, Wei Zhu, Shengyuan Zhou, Zhiwei Wang, Xiongsheng Chen, Lianshun Jia
Aims: To explicit cell apoptosis trend in PC12 oxygen-glucose-serum deprivation/restoration (OGSD/R) model and provide experimental bases for neural cell simulation in ischemia reperfusion injury in vitro. Methods: OGSD/R model was constructed using the passage PC12 cells in vitro. The profile of cell apoptosis was estimated by DAPI staining, Annexin V-FITC and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, as well as the levels of apoptosis-related proteins, including procaspase-3 and caspase-12...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163464/nlrp3-inflammasome-mediates-dormant-neutrophil-recruitment-following-sterile-lung-injury-and-protects-against-subsequent-bacterial-pneumonia-in-mice
#3
Xiaoli Tian, He Sun, Amy-Jo Casbon, Edward Lim, Kevin P Francis, Judith Hellman, Arun Prakash
Sterile lung injury is an important clinical problem that complicates the course of severely ill patients. Interruption of blood flow, namely ischemia-reperfusion (IR), initiates a sterile inflammatory response in the lung that is believed to be maladaptive. The rationale for this study was to elucidate the molecular basis for lung IR inflammation and whether it is maladaptive or beneficial. Using a mouse model of lung IR, we demonstrate that sequential blocking of inflammasomes [specifically, NOD-, LRR-, and pyrin domain-containing 3 (NLRP3)], inflammatory caspases, and interleukin (IL)-1β, all resulted in an attenuated inflammatory response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163163/guanxin-danshen-formulation-protects-against-myocardial-ischemia-reperfusion-injury-induced-left-ventricular-remodeling-by-upregulating-estrogen-receptor-%C3%AE
#4
Xuehong Deng, Xiaoyan Xing, Guibo Sun, Xudong Xu, Haifeng Wu, Guang Li, Xiaobo Sun
Background: Guanxin Danshen formulation (GXDSF) is a traditional Chinese herbal recipe recorded in the Chinese Pharmacopeia since 1995 edition, which consists of Salviae miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Dalbergiae odoriferae Lignum. Our previous research suggested GXDSF had positive effect on cardiovascular disease. Therefore, the aim of this study was to elucidate the effects of GXDSF on myocardial ischemia reperfusion injury-induced left ventricular remodelling (MIRI-LVR). Methods: The effects of GXDSF on cardiac function were detected by haemodynamics and echocardiograms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163161/inhibition-of-mir-128-3p-by-tongxinluo-protects-human-cardiomyocytes-from-ischemia-reperfusion-injury-via-upregulation-of-p70s6k1-p-p70s6k1
#5
Gui-Hao Chen, Chuan-Sheng Xu, Jie Zhang, Qing Li, He-He Cui, Xiang-Dong Li, Li-Ping Chang, Rui-Jie Tang, Jun-Yan Xu, Xia-Qiu Tian, Pei-Sen Huang, Jun Xu, Chen Jin, Yue-Jin Yang
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases. However, no studies have explored whether TXL can protect human cardiomyocytes (HCMs) from ischemia/reperfusion (I/R) injury. Reperfusion Injury Salvage Kinase (RISK) pathway activation was previously demonstrated to protect the hearts against I/R injury and it is generally activated via Akt or (and) Erk 1/2, and their common downstream protein, ribosomal protein S6 kinase (p70s6k)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163038/electroacupuncture-suppresses-the-nf-%C3%AE%C2%BAb-signaling-pathway-by-upregulating-cylindromatosis-to-alleviate-inflammatory-injury-in-cerebral-ischemia-reperfusion-rats
#6
Jin Jiang, Yong Luo, Wenyi Qin, Hongmei Ma, Qiongli Li, Jian Zhan, Ying Zhang
Electroacupuncture (EA) may reduce inflammatory injury by inhibiting nuclear factor-kappa B (NF-κB) signaling pathway activation after ischemic stroke. Thus, we explored temporal and spatial expression of cylindromatosis (CYLD), a negative feedback inhibitor of the NF-κB signaling pathway, to learn whether CYLD is essential for EA and reduction of inflammatory injury after focal cerebral ischemia/reperfusion. A middle cerebral artery occlusion/reperfusion (MCAO/R) model was established in male Sprague-Dawley (SD) rats and CYLD gene interference was used to investigate a potential role of neuroprotection...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29163033/phosphorylation-at-s153-as-a-functional-switch-of-phosphatidylethanolamine-binding-protein-1-in-cerebral-ischemia-reperfusion-injury-in-rats
#7
Zhong Wang, Jiyuan Bu, Xiyang Yao, Chenglin Liu, Haitao Shen, Xiang Li, Haiying Li, Gang Chen
This study aimed to estimate the role of phosphatidylethanolamine binding protein 1 (PEBP1) in cerebral ischemia-reperfusion (I/R) injury and the underlying mechanisms. Middle cerebral artery occlusion/reperfusion (MCAO/R) model in adult male Sprague Dawley rats (250-280 g) were established and cultured neurons were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) to mimic I/R injury in vitro. Expression vectors encoding wild-type PEBP1 and PEBP1 with Ser153Ala mutation (S153A), PEBP1 specific siRNAs, and human recombinant PEBP1 (rhPEBP1) were administered intracerebroventricularly...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29163008/antioxidative-and-antiapoptotic-effects-of-delta-opioid-peptide-d-ala-2-d-leu-5-enkephalin-on-spinal-cord-ischemia-reperfusion-injury-in-rabbits
#8
Danyun Fu, Haitong Liu, Shitong Li, Lianhua Chen, Junyan Yao
Background: In our previous study, we found that regional administration of delta-opioid peptide [D-Ala(2), D-Leu(5)] enkephalin (DADLE) could provide dose-dependent protection on spinal cord ischemia-reperfusion (I/R) injury in rabbits. However, the relative protective molecular mechanisms underlying this neuroprotection remain unclear. The purpose of this study was to investigate whether DADLE provided the protection in spinal cord I/R injury through its antioxidant property by decreasing malondialdehyde (MDA) and nitric oxide (NO) levels and increasing glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels and through its antiapoptotic capacity by inhibiting caspase-3 and p53 expression...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29161807/intravenous-dextran-70-infusion-has-protective-effects-on-ischemia-reperfusion-injury-of-kidney-an-experimental-study
#9
Atilla Semercioz, Mustafa Z Temiz, Ipek Erbarut, Ugur Izol, Serdar Aykan, Murat Tuken, Engin Kandirali
BACKGROUND: Renal ischemia-reperfusion (IR) leads to alterations of tubular epithelial cells, interstitial microvasculopathy and endothelial cell dysfunction in peritubular capillaries. Although dextrans have deteriorative effects on healthy kidney, their favorable effects on post-ischemic microvascular disturbances have been demonstrated. Therefore, we aimed to investigate in vivo effects of systemic Dextran 70 administration in kidney tissue with ischemia-reperfusion injury. METHODS: Twenty-one rats were allocated as sham, IR and IR+ Dextran 70 treatment groups...
November 21, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29161281/the-administration-of-hydrogen-sulphide-prior-to-ischemic-reperfusion-has-neuroprotective-effects-in-an-acute-stroke-model
#10
Chul-Woong Woo, Jae-Im Kwon, Kyung-Won Kim, Jeong-Kon Kim, Sang-Beom Jeon, Seung-Chae Jung, Choong-Gon Choi, Sang-Tae Kim, Jinil Kim, Su Jeong Ham, Woo-Hyun Shim, Yu Sub Sung, Hyun Kwon Ha, Yoonseok Choi, Dong-Cheol Woo
Emerging evidence has suggested that hydrogen sulfide (H2S) may alleviate the cellular damage associated with cerebral ischemia/reperfusion (I/R) injury. In this study, we assessed using 1H-magnetic resonance imaging/magnetic resonance spectroscopy (1H-MRI/MRS) and histologic analysis whether H2S administration prior to reperfusion has neuroprotective effects. We also evaluated for differences in the effects of H2S treatment at 2 time points. 1H-MRI/MRS data were obtained at baseline, and at 3, 9, and 24 h after ischemia from 4 groups: sham, control (I/R injury), sodium hydrosulfide (NaHS)-30 and NaHS-1 (NaHS delivery at 30 and 1 min before reperfusion, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/29160373/the-role-of-histone-deacetylase-inhibitors-in-regulation-of-akt-gsk-3%C3%AE-signaling-pathway-in-mice-following-transient-focal-cerebral-ischemia
#11
Bo Zhao, Lian Liu, Yan Leng, Quan Yuan, Jiabao Hou, Yang Wu, Wenwei Gao
PURPOSE: To investigate whether the neuroprotective effect of TSA on cerebral ischemia reperfusion injury is mediated by the activation of Akt/GSK-3β signaling pathway. METHODS: Mice were randomly divided into four groups (n=15): sham group (S); ischemia reperfusion group (IR); ischemia reperfusion and pretreated with TSA group (IR+T); ischemia reperfusion and pretreated with TSA and LY294002 group (IR+T+L). The model of cerebral ischemia reperfusion was established by 1h of MCAO following 24h of reperfusion...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29160368/the-effects-of-local-ischemic-preconditioning-and-topical-hypothermia-in-renal-ischemia-reperfusion-injury-in-rats
#12
Guilherme Behrend Ribeiro, Emanuel Burck Dos Santos, Silvia Regina Bona, Pedro Guilherme Schaefer, Tuane Alves Garcez, Eduardo Brasil Rabolini, Guilherme Pereira Smaniotto, Norma Possa Marroni, Carlos Otávio Corso
PURPOSE: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. METHODS: Post right nephrectomy, 40 male Wistar rats were randomly assigned to five experimental protocols performed in the left kidney: topical hypothermia without ischemia (TH), warm ischemia (IR), ischemic preconditioning followed by warm ischemia (IPC+IR), cold ischemia (TH+IR), and ischemic preconditioning followed by cold ischemia (IPC+TH+IR)...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29160366/erdosteine-ameliorates-the-harmful-effects-of-ischemia-reperfusion-injury-on-the-liver-of-rats
#13
Aziz Mutlu Barlas, Kemal Kismet, Serap Erel, Serdar Kuru, Turgut Cavusoglu, Mehmet Senes, Zeynep Adiyaman, Pinar Celepli, Sema Hucumenoglu, Recep Pekcici
PURPOSE: To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model. METHODS: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other manipulation or treatment was performed. In the other groups, ischemia was achieved by clamping the hepatic pedicle for 60 min. After that, 90 min reperfusion was provided. In the control group, no treatment was given...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29160083/mechanisms-and-applications-of-redox-sensitive-gfp-based-h2o2-probes
#14
Leticia Prates Roma, Marcel Deponte, Jan Riemer, Bruce Morgan
SIGNIFICANCE: Genetically encoded H2O2 sensors, based upon fusions between thiol peroxidases and redox-sensitive green fluorescent protein 2 (roGFP2) have dramatically broadened the available 'toolbox' for monitoring cellular H2O2 changes. Recent advances: Recently developed peroxiredoxin-based probes such as roGFP2-Tsa2∆CR offer considerably improved H2O2-sensitivity compared to previously available genetically encoded sensors and now permit dynamic, real-time, monitoring of changes in endogenous H2O2 levels...
November 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29159507/stat3-as-a-common-signal-of-ischemic-conditioning-a-lesson-on-rigor-and-reproducibility-in-preclinical-studies-on-cardioprotection
#15
Petra Kleinbongard, Andreas Skyschally, Sabine Gent, Marion Pesch, Gerd Heusch
Ischemic conditioning before (ischemic preconditioning, IPC) or after (ischemic postconditioning, POCO) sustained myocardial ischemia/reperfusion (I/R), induced locally or remotely from the heart (remote IPC, RIPC), reduces infarct size. However, none of the identified signaling steps of ischemic conditioning was robust across models and species to be successfully translated to humans. In prior separate studies in pigs, activation of signal transducer and activator of transcription 3 (STAT3) was causal for infarct size reduction by IPC, POCO, and RIPC but it remains unclear whether or not STAT3 is truly a common denominator of cardioprotective signaling...
November 20, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29156826/protective-effect-of-ginkgo-biloba-leaves-extract-egb761-on-myocardium-injury-in-ischemia-reperfusion-rats-via-regulation-of-tlr-4-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Yuping Tang, Guisheng Zhou, Lijun Yao, Ping Xue, Danhong Yu, Renjie Xu, Wen Shi, Xin Yao, Zhaowei Yan, Jin-Ao Duan
Beneficial actions of EGb 761 against ischemia/reperfusion (I/R) injury in lung, brain and renal ischemia have been described. However, the relationship between EGb 761 and signal molecules in myocardial ischemia reperfusion has not been well elucidated. In this study, we investigated the effects and mechanism of EGb 761 preconditioning on anti-myocardial I/R injuries in vivo. Meanwhile, their potential anti-oxidative stress and anti-inflammation effect were assessed. Hemodynamic parameters were monitored as left ventricular systolic pressure, LV end-diastolic pressure and maximal rate of increase and decrease of left ventricular pressure (dP/dtmax)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156814/screening-circular-rna-expression-patterns-following-focal-cerebral-ischemia-in-mice
#17
Cuiying Liu, Chencheng Zhang, Jian Yang, Xiaokun Geng, Huishan Du, Xunming Ji, Heng Zhao
Circular RNAs (circRNAs) have been demonstrated to act as microRNA (miRNA) sponges and they play important roles in regulating gene expression through a circRNA-miRNA-gene pathway. The specific roles of circRNAs in the pathogenesis of cerebral ischemia, however, are still unclear. Thus, the aim of this study is to determine circRNA expression profiles in the ischemic brain after stroke, which was induced by 45 min of transient middle cerebral artery occlusion (MCAO). The results from the circRNA microarrays revealed that 1027 circRNAs were significantly altered 48 hours after reperfusion in the ischemic brain compared with the sham group...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156799/asiatic-acid-protects-against-hepatic-ischemia-reperfusion-injury-by-inactivation-of-kupffer-cells-via-ppar%C3%AE-nlrp3-inflammasome-signaling-pathway
#18
Ying Xu, Jun Yao, Chen Zou, Heng Zhang, Shouliang Zhang, Jun Liu, Gui Ma, Pengcheng Jiang, Wenbo Zhang
Hepatic ischemia/reperfusion (I/R) contributes to major complications in clinical practice affecting perioperative morbidity and mortality. Recent evidence suggests the key role of nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammaosme activation on the pathogenesis of I/R injury. Asiatic acid (AA) is a pentacyclic triterpene derivative presented with versatile activities, including antioxidant, anti-inflammation and hepatoprotective effects. This study was designed to determine whether AA had potential hepatoprotective benefits against hepatic I/R injury, as well as to unveil the underlying mechanisms involved in the putative effects...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155898/protective-effect-of-malva-sylvestris-l-extract-in-ischemia-reperfusion-induced-acute-kidney-and-remote-liver-injury
#19
Houshang Najafi, Zeynab Mohamadi Yarijani, Saeed Changizi-Ashtiyani, Kamran Mansouri, Masoud Modarresi, Seyed Hamid Madani, Bahar Bastani
Mallow (Malva sylvestris L.) has had medicinal and therapeutic uses in addition to its oral consumption. The present study was conducted to examine the protective effect of Malva sylvestris L. extract on ischemia-reperfusion-induced kidney injury and remote organ injuries in the liver. Before ischemia-reperfusion, rats in the different groups received intraperitoneal normal saline or mallow extract at the doses of 200, 400 or 600 mg/kg of body weight. After 30-minutes of bilateral renal ischemia followed by 24-hours of reperfusion, tissue damage in the kidney and liver samples were determined through studying H&E-stained slides under a light microscope...
2017: PloS One
https://www.readbyqxmd.com/read/29155261/the-phosphodiesterase-4-inhibitor-fcpr16-attenuates-ischemia-reperfusion-injury-in-rats-subjected-to-middle-cerebral-artery-occlusion-and-reperfusion
#20
Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Yufang Cheng, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng, Jiangping Xu
Current phosphodiesterase-4 (PDE4) inhibitors exert beneficial effects in central nervous system diseases via anti-inflammatory and anti-apoptotic properties, but many of them are plagued by side effects like nausea and emesis. FCPR16, a novel PDE4 inhibitor synthesized in our lab, has potential anti-inflammatory property. In the present study, we aimed to investigate the effects of FCPR16 in a rat model of ischemic stroke and evaluate its emetogenic potential. Our results showed that FCPR16 treatment improved neurological function, reduced cerebral infarct volume, and attenuated brain histological changes in rats subjected to middle cerebral artery occlusion and reperfusion (MCAO/R)...
November 16, 2017: Brain Research Bulletin
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