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https://www.readbyqxmd.com/read/29766686/multimodal-approach-in-assessment-of-the-response-of-breast-cancer-to-neoadjuvant-chemotherapy
#1
Mikhail Viktorovich Pavlov, Tatyana Igorevna Kalganova, Yekaterina Sergeevna Lyubimtseva, Vladimir Ivanovich Plekhanov, German Yurievich Golubyatnikov, Olga Yevgenyevna Ilyinskaya, Anna Gennadjevna Orlova, Pavel Vladimirovich Subochev, Dmitriy Vladimirovich Safonov, Natalia Mikhailovna Shakhova, Anna Vladimirovna Maslennikova
The ability for noninvasive visualization of functional changes of a tumor's oxygenation and circulatory system offers new advantages for prognosis and monitoring of the treatment efficacy. The results of breast cancer oxygen state study under chemotherapy action obtained by diffuse optical spectroscopy (DOS) in combination with Doppler ultrasonic imaging are presented. Complex use of optical and ultrasound methods gives complementary information about the size of the tumor node, peculiarities of its vascular bed, rate of its blood flow as well as oxygenation, and provide a picture of the tumor response to treatment...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29766604/sodium-nitroglycerin-induces-middle-cerebral-artery-vasodilation-in-young-healthy-adults
#2
Jenna M Schulz, Baraa K Al-Khazraji, J Kevin Shoemaker
Recent evidence indicates that basal cerebral conduit vessels dilate with hypercapnia, with a nitric oxide (NO) mechanism explaining one way in which parenchymal cerebral arterioles dilate. However, whether NO affects basal cerebral artery dilation remains unknown. This study quantified the effect of an exogenous NO donor [sodium nitroglycerin (NTG); 0.4 mg sublingual spray] on the right middle cerebral artery (rMCA) cross-sectional area (CSA), blood velocity and overall blood flow. Measures of vessel CSA (7 Tesla magnetic resonance imaging) and MCA blood velocity (transcranial Doppler ultrasound) were made at baseline (BL), and following exogenous NTG or placebo (PLO) administration in young, healthy individuals (n = 10, 2 males, age range 20-23 years)...
May 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29753957/brainstem-blood-brain-barrier-disruption-using-focused-ultrasound-a-demonstration-of-feasibility-and-enhanced-doxorubicin-delivery
#3
Saira Alli, Carlyn A Figueiredo, Brian Golbourn, Nesrin Sabha, Megan Yijun Wu, Andrew Bondoc, Amanda Luck, Daniel Coluccia, Colin Maslink, Christian Smith, Heiko Wurdak, Kullervo Hynynen, Meaghan O'Reilly, James T Rutka
Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve transient BBB opening without tissue injury. Delivery of a targeted ultrasonic wave causes an interaction between administered microbubbles and the capillary bed resulting in enhanced vessel permeability. The use of MRgFUS in the brainstem has not previously been shown but could provide value in the treatment of tumours such as Diffuse Intrinsic Pontine Glioma (DIPG) where the intact BBB has contributed to the limited success of chemotherapy...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29730685/the-microvascular-and-morphostructural-changes-of-nails-in-psoriatic-patients-with-nail-disease-a-link-between-ultrasound-and-videocapillaroscopy-findings-in-the-nailfold
#4
Sibel Bakirci Ureyen, Rabia Oztas Kara, Zeynep Erturk, Mahizer Yaldiz
OBJECTIVE: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs). MATERIAL AND METHODS: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29717293/percutaneous-renal-biopsy-comparison-of-blind-and-real-time-ultrasound-guided-technique
#5
Anil Pokhrel, Rajendra Kumar Agrawal, Anil Baral, Ajaya Rajbhandari, Rajani Hada
BACKGROUND: Percutaneous renal biopsy is performed for diagnosis and prediction of prognosis of renal diseases. Adequacy of tissue and clinically significant bleeding are the main issues of the procedure. We aimed to compare these issues in renal biopsy by blind and real time ultrasound guided technique. METHODS: It was a cross sectional, randomized study conducted between June 2016 to December 2016. In blind technique, marking for biopsy was done by ultrasound...
March 13, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29709051/thoracic-ultrasound-for-the-detection-of-rib-metastases-of-non-small-cell-lung-cancer
#6
Ioannis Tomos, Nikos Tziolos, Thomas Raptakis, Dimitra Kavatha
Transthoracic ultrasound has lately emerged as a useful diagnostic tool for respiratory physicians in the diagnosis of diverse pulmonary diseases, usually including pleural effusion and pneumothorax. However, the use of chest ultrasound may be also critical in the evaluation of chest wall diseases. Therefore, we present an interesting case of a patient with metastases of lung cancer to the rib, detected during the chest wall ultrasound examination. By representing a non-invasive, surface-imaging technique with several advantages, chest ultrasound may evolve to a valid, bed-side diagnostic tool for the diagnosis and follow up of lung cancer with metastases in the chest wall...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29706002/-subclinical-enthesopathy-of-at-least-one-extensor-digitorum-tendon-is-highly-prevalent-and-associated-with-clinical-and-ultrasound-alterations-of-the-adjacent-finger-nails-in-patients-with-psoriatic-disease
#7
P Moya Alvarado, E Roé Crespo, F Z Muñoz-Garza, A López-Ferrer, A Laiz Alonso, E Vilarrassa Rull, J Casademont, L Puig Sanz
BACKGROUND: Nail psoriasis disease is associated with an increased probability of psoriatic arthritis and its clinical signs may have different correlates with the pathogenesis of adjacent bone destruction and have different prognostic value. Recent publications about psoriasis and nail psoriatic disease describe different ultrasonographic findings but the relationship between these ungueal alterations measured by ultrasonography and the presence of enthesopathy of the extensor digitorum has yet to be discovered...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29703223/comparison-of-exercise-intensity-during-four-early-rehabilitation-techniques-in-sedated-and-ventilated-patients-in-icu-a-randomised-cross-over-trial
#8
Clément Medrinal, Yann Combret, Guillaume Prieur, Aurora Robledo Quesada, Tristan Bonnevie, Francis Edouard Gravier, Elise Dupuis Lozeron, Eric Frenoy, Olivier Contal, Bouchra Lamia
BACKGROUND: In the ICU, out-of-bed rehabilitation is often delayed and in-bed exercises are generally low-intensity. Since the majority of rehabilitation is carried out in bed, it is essential to carry out the exercises that have the highest intensity. The aim of this study was to compare the physiological effects of four common types of bed exercise in intubated, sedated patients confined to bed in the ICU, in order to determine which was the most intensive. METHODS: A randomised, single-blind, placebo-controlled crossover trial was carried out to evaluate the effects of four bed exercises (passive range of movements (PROM), passive cycle-ergometry, quadriceps electrical stimulation and functional electrical stimulation (FES) cycling) on cardiac output...
April 27, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29703013/treatment-of-hemangioma-of-the-spleen-by-preoperative-partial-splenic-embolization-plus-laparoscopic-partial-splenectomy-a-case-report
#9
Lu Zheng, Changlin Deng, Jing Li, Liang Wang, Nan You, Ke Wu, Weiwei Wang
RATIONALE: Complete loss of splenic function increases infection and cardiovascular disease risks, so there is growing emphasis on spleen-preserving treatments, such as laproscopic partial splenectomy (LPS). However, LPS carries higher risk for hemorrhage. Sequential splenic embolization can obliterate the perilesional vascular bed while preserving flow through healthy tissue, substantially reducing risk of uncontrolled hemorrhage during LPS. Preoperative partial splenic embolization (PSE) may soften the spleen and reduce its size, which enhances space exposure for laparoscopic operation...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29685086/preoperative-localization-of-recurrence-in-the-thyroidectomy-bed-using-a-radioactive-iodine-125-seed
#10
Hillary W Garner, Ricardo Paz-Fumagalli, Geoffrey D Young
Intraoperative localization of nonpalpable recurrent thyroid cancer has been reported using needle localization, intraoperative ultrasound (US), dye injection, and radio-guided surgery. We describe the alternative technique of radioactive seed localization (RSL) in 3 patients with residual or recurrent papillary thyroid cancer. This technique has been used for many years in the setting of nonpalpable breast cancer, where it has been shown to be safe and has been associated with greater surgeon satisfaction as well as improved patient tolerability, cosmesis, and outcomes compared to needle localization...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29667115/biopsy-feasibility-trial-for-breast-cancer-pathologic-complete-response-detection-after-neoadjuvant-chemotherapy-imaging-assessment-and-correlation-endpoints
#11
Gaiane M Rauch, Henry M Kuerer, Beatriz Adrada, Lumarie Santiago, Tanya Moseley, Rosalind P Candelaria, Elsa Arribas, Jia Sun, Jessica W T Leung, Savitri Krishnamurthy, Wei T Yang
PURPOSE: This study was designed to present the secondary imaging endpoints of the trial for evaluating mammogram (MMG), ultrasound (US) and image guided biopsy (IGBx) assessment of pathologic complete response (pCR) in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS: Patients with T1-3, N0-3, M0 triple-negative or HER2-positive BC who received NAC were enrolled in an Institutional Review Board-approved prospective, clinical trial...
April 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29665013/planhab-hypoxia-does-not-worsen-the-impairment-of-skeletal-muscle-oxidative-function-induced-by-bed-rest-alone
#12
Desy Salvadego, Michail E Keramidas, Roger Kölegård, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Jörn Rittweger, Ola Eiken, Igor B Mekjavic, Bruno Grassi
KEY POINTS: Superposition of hypoxia on 21 day bed rest did not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. A significant impairment of maximal oxidative performance was identified downstream of cardiovascular O2 delivery, involving both the intramuscular matching between O2 supply and utilization and mitochondrial respiration. These chronic adaptations appear to be relevant in terms of exposure to spaceflights and reduced gravity habitats (Moon or Mars), as characterized by low gravity and hypoxia, in patients with chronic diseases characterized by hypomobility/immobility and hypoxia, as well as in ageing...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29621904/the-birth-canal-correlation-between-the-pubic-arch-angle-the-interspinous-diameter-and-the-obstetrical-conjugate-a-computed-tomography-biometric-study-in-reproductive-age-women
#13
Sharon Perlman, Lisa Raviv-Zilka, Denis Levinsky, Ayelet Gidron, Reuven Achiron, Yinon Gilboa, Zvi Kivilevitch
BACKGROUND: Assessment of pelvic configuration is an important factor in the prediction of a successful vaginal birth. However, manual evaluation of the pelvis is practically a vanishing art, and imaging techniques are not available as a real time bed side tool. Unlike the obstetrical conjugate diameter (OC) and inter spinous diameter (ISD), the pubic arch angle (PAA) can be easily measured by transperineal ultrasound. OBJECTIVES: Three dimensional computed tomography bone reconstructions were used to measure the three main birth canal diameters, evaluate the correlation between them and establish the normal reference range for the inlet, mid- and pelvic outlet...
April 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29597222/clinical-complications-of-continuous-renal-replacement-therapy
#14
Florent Sigwalt, Axelle Bouteleux, François Dambricourt, Théo Asselborn, Florent Moriceau, Thomas Rimmelé
The various complications of continuous renal replacement therapy (CRRT) are mostly preventable. Hemodynamic disturbances are dominated by hypotension due to the modification of volume status, myocardial dysfunction, cardiac arrhythmia, or modification of systemic vascular resistances, which are correlated with body temperature changes. Metabolic complications remain at the forefront and have profoundly changed with the use of regional citrate anticoagulation (RCA). RCA may lead to two distinct situations: citrate overload and citrate accumulation, respectively, responsible for metabolic alkalosis and metabolic acidosis...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29588620/in-room-ultrasound-fusion-combined-with-fully-compatible-3d-printed-holding-arm-rethinking-interventional-mri
#15
Michael Friebe, Juan Sanchez, Sathish Balakrishnan, Alfredo Illanes, Yeshaswini Nagaraj, Robert Odenbach, Marwah Matooq, Gabriele Krombach, Michael Vogele, Axel Boese
There is no real need to discuss the potential advantages - mainly the excellent soft tissue contrast, nonionizing radiation, flow, and molecular information - of magnetic resonance imaging (MRI) as an intraoperative diagnosis and therapy system particularly for neurological applications and oncological therapies. Difficult patient access in conventional horizontal-field superconductive magnets, very high investment and operational expenses, and the need for special nonferromagnetic therapy tools have however prevented the widespread use of MRI as imaging and guidance tool for therapy purposes...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29583023/a-viable-caesarean-scar-pregnancy-in-a-woman-using-a-levonorgestrel-releasing-intrauterine-device-a-case-report
#16
Emilie Hitzerd, Hein Bogers, Noush A Kianmanesh Rad, Johannes J Duvekot
BACKGROUND: Although the levonorgestrel-releasing intrauterine device (LNG-IUD) is one of the most reliable methods of contraception, it is associated with an increased risk of ectopic pregnancy in case of unintended pregnancy. A rare form of ectopic pregnancy is the caesarean scar pregnancy (CSP), with a high risk of serious maternal morbidity, such as uterine rupture, massive haemorrhage and resulting infertility. This report describes the first case of a viable CSP at 13 weeks of gestation in association with the use of a LNG-IUD...
March 27, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29572909/mathematical-modeling-of-the-adsorption-desorption-characteristics-of-anthocyanins-from-muscadine-vitis-rotundifolia-cv-noble-juice-pomace-on-amberlite-fpx66-resin-in-a-fixed-bed-column
#17
Chad G Uzdevenes, Chi Gao, Amandeep K Sandhu, Yavuz Yagiz, Liwei Gu
BACKGROUND: Muscadine grape pomace, a by-product of juicing and wine-making, contains significant amounts of anthocyanin 3,5-diglucosides, known to be beneficial to human health. RESULTS: The objective of this research was to use mathematical modeling to investigate the adsorption/desorption characteristics of these anthocyanins from muscadine grape pomace on Amberlite FPX66 resin in a fixed bed column. Anthocyanins were extracted using hot water and ultrasound, and the extracts were loaded onto a resin column at five bed depths (5, 6, 8, 10, or 12 cm) using three flow rates (4, 6, or 8 mL/min)...
March 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29534984/fibromuscular-dysplasia-contemporary-concepts-and-future-directions
#18
REVIEW
Nupoor Narula, Daniella Kadian-Dodov, Jeffrey W Olin
Fibromuscular dyplasia (FMD) is an under-recognized non-atherosclerotic, non-inflammatory arteriopathy that occurs most commonly in middle-aged women, but may affect individuals of all age groups. FMD may result in stenosis, aneurysm, dissection, occlusion, or arterial tortuosity. Recently published data demonstrated a genetic association of FMD with a variant in the phosphatase and actin regulator 1 gene (PHACTR1), substantiating that the pathogenesis of this condition has genetic contribution. The renal and extracranial carotid and vertebral arteries are most often involved, although any arterial bed may be affected...
March 10, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29534383/-application-of-continuous-serratus-plane-block-with-patient-controlled-analgesia-on-postoperation-analgesia-after-thoracoscopic-surgery
#19
K Deng, S J Xu, Y F Qian, G D Chen, X Z Yuan, X Y Zhou, M Yao
Objective: To investigate the application of ultrasound-guided continuous serratus plane block with patient-controlled analgesia on postoperation analgesia after thoracoscopic surgery, and influence on postoperative rehabilitation. Methods: Sixty patients scheduled for thoracoscopic surgery were randomly divided into two groups. PCNA group ( n =30) received ultrasound guided continuous serratus plane block with patient-controlled nerve analgesia, with continuous infusion of 0.2% ropivacaine and 30 ml of 0.3% ropivacaine for the first does...
February 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29531735/portal-vein-thrombosis-after-cesarean-section-in-a-patient-on-prolonged-bed-rest-due-to-threatened-preterm-labor
#20
Arata Hibi, Kazumasa Mogi
Portal vein thrombosis is a rare but life-threatening complication during pregnancy and postpartum period. Color Doppler ultrasound is useful for prompt diagnosis. Although the risk of complications should be considered, successful pregnancy with comorbid portal vein thrombosis is possible with appropriate anticoagulation therapy and close monitoring.
March 2018: Clinical Case Reports
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