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https://www.readbyqxmd.com/read/27913478/thrombosis-in-the-setting-of-obesity-or-inflammatory-bowel-disease
#1
Steven R Lentz
Obesity and inflammatory bowel disease (IBD) are systemic inflammatory disorders that predispose to arterial and venous thrombosis through similar prothrombotic mechanisms. Obesity and IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the thrombotic risk with IBD appears to wax and wane with disease severity. Because of the lack of high-quality evidence to guide management decisions, approaches to the prevention and treatment of thrombosis in patients with obesity or IBD are based on extrapolation from general guidelines for antithrombotic therapy...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27911976/demographic-and-clinical-characteristics-of-a-predominantly-hispanic-population-with-inflammatory-bowel-disease-on-the-us-mexico-border
#2
Antonio Mendoza Ladd, Yi Jia, Christine Yu, Sherif Elhanafi, Alok Dwivedi, Jiayang Liu, Giangqing Song, Mark Hall, Marc J Zuckerman
OBJECTIVES: Information regarding Hispanics with inflammatory bowel disease (IBD) is scarce. In this study we aimed to describe a predominantly Hispanic population with IBD in a city located along the US-Mexico border and to identify clinical or demographic differences between Hispanics and non-Hispanics. METHODS: Retrospective cohort analysis of patients with IBD between 2003 and 2013 at a tertiary care center. Information collected included age, sex, ethnicity, diagnosis, diagnosis status (new vs old), endoscopic extent of disease (EOD), extraintestinal manifestations, medical treatment, and surgeries performed...
December 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27902515/comparison-of-health-related-quality-of-life-and-disability-in-ulcerative-colitis-patients-following-restorative-proctocolectomy-with-ileal-pouch-anal-anastomosis-versus-anti-tumor-necrosis-factor-therapy
#3
Sara van Gennep, Saloomeh Sahami, Christianne J Buskens, Gijs R van den Brink, Cyriel Y Ponsioen, André D'Hoore, Anthony de Buck van Overstraeten, Gert van Assche, Marc Ferrante, Séverine Vermeire, Willem A Bemelman, Geert R A M D'Haens, Mark Löwenberg
BACKGROUND AND AIMS: Health-related quality of life (HRQL) and disability were compared in ulcerative colitis (UC) patients who underwent restorative proctocolectomy versus patients who received treatment with anti-tumor necrosis factor (anti-TNF) agents. PATIENTS AND METHODS: UC patients who underwent restorative proctocolectomy or started anti-TNF treatment between January 2010 and January 2015 were included at two tertiary referral centers. A matched cohort was created using propensity score matching for the covariates disease duration, Montreal classification, age, and sex...
November 29, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27899815/obesity-in-ibd-epidemiology-pathogenesis-disease-course-and-treatment-outcomes
#4
REVIEW
Siddharth Singh, Parambir S Dulai, Amir Zarrinpar, Sonia Ramamoorthy, William J Sandborn
Incidence of IBD is rising in parallel with overweight and obesity. Contrary to conventional belief, about 15-40% of patients with IBD are obese, which might contribute to the development of IBD. Findings from cross-sectional and retrospective cohort studies are conflicting on the effect of obesity on natural history and course of IBD. Most studies are limited by small sample size, low event rates, non-validated assessment of disease activity and lack robust longitudinal follow-up and have incomplete adjustment for confounding factors...
November 30, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27892896/c-reactive-protein-as-a-diagnostic-and-prognostic-factor-in-inflammatory-bowel-diseases
#5
Dorota Mańkowska-Wierzbicka, Jacek Karczewski, Barbara Poniedziałek, Małgorzata Grzymisławska, Rafał Staszewski, Aleksandra Królczyk, Agnieszka Dobrowolska, Marian Grzymisławski
AIM: The study aimed to evaluate high-sensitivity CRP (hsCRP) as a diagnostic and predictive marker in patients with inflammatory bowel disease (IBD). MATERIAL/METHODS: Medical history of 106 patients with IBD revealed hsCRP concentrations at diagnosis and during the follow-up period. RESULTS: The study showed that the majority of investigated patients had elevated hsCRP concentrations at diagnosis, although the mean concentration was much higher in the group of patients with Crohn's disease (CD) than the group with ulcerative colitis (UC) (P<0...
November 7, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27889942/sword-a-sharp-performance-and-activity-tool-for-ibd-surgeons-with-a-blunt-message
#6
A G Acheson, S R Brown, O Faiz, N S Fearnhead
High quality performance and activity data for surgery are paramount in maintaining good clinical practice and for quality improvement initiatives. Clinical Outcome Publication (COP) is an NHS England initiative that publishes quality measures following elective bowel cancer surgery at individual consultant and Trust level using National Audit data. This article is protected by copyright. All rights reserved.
November 27, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27887705/perceptions-on-the-surgical-treatment-of-inflammatory-bowel-disease-in-spain-results-of-a-national-survey
#7
Luis Sánchez-Guillén, Francisco Blanco-Antona, Mónica Millán-Scheiding
INTRODUCTION: The incidence of inflammatory bowel disease (IBD) is increasing in Spain but there is little information on the availability of multidisciplinary care. This study aims to assess surgeon's opinions on the current situation of surgery for IBD in Spain. METHODS: An electronic closed survey was sent to members of the Spanish Association of Surgeons (AEC) from January to March 2015. This was a 52-item anonymised questionnaire with questions about how the treatment of IBD patients is organized in each centre, the existence of specific units, the management strategy in IBD patients, and the opinion of colorectal, general and trainee surgeons about the surgical treatment of IBD in their centre and in Spain...
November 22, 2016: Cirugía Española
https://www.readbyqxmd.com/read/27875353/cannabinoid-receptor-2-functional-variant-contributes-to-the-risk-for-pediatric-inflammatory-bowel-disease
#8
Caterina Strisciuglio, Giulia Bellini, Erasmo Miele, Massimo Martinelli, Sabrina Cenni, Chiara Tortora, Carlo Tolone, Emanuele Miraglia Del Giudice, Francesca Rossi
GOALS: We conducted a case-control association analysis to establish the role of a common CB2 functional variant, Q63R, in the susceptibility to inflammatory bowel disease (IBD). BACKGROUND: Endocannabinoids may limit intestinal inflammation through cannabinoid receptor 1 and/or 2 (CB1, CB2). STUDY: We genotyped 217 pediatric IBD patients [112 Crohn's disease (CD), 105 ulcerative colitis (UC)] and 600 controls for the CB2-Q63R variant by Taqman assay...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27872836/urolithiasis-in-inflammatory-bowel-disease-and-bariatric-surgery
#9
Agapios Gkentzis, Michael Kimuli, Jon Cartledge, Olivier Traxer, Chandra Shekhar Biyani
AIM: To analyse current literature focusing on pathogenesis and therapeutic aspects of urolithiasis with inflammatory bowel disease (IBD) and following bariatric surgery. METHODS: A systematic literature search was performed using PubMed, supplemented with additional references. Studies assessing the association of IBD or bariatric surgery with renal stones in both paediatric and adulthood were included. RESULTS: Certain types of stones are seen more frequently with IBD...
November 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27867689/family-history-and-disease-outcomes-in-patients-with-crohn-s-disease-a-comparison-between-china-and-the-united-states
#10
Pei-Qi Wang, Jun Hu, Elie S Al Kazzi, Eboselume Akhuemonkhan, Min Zhi, Xiang Gao, Raquel Holand de Paula Pessoa, Sami Ghazaleh, Tuhina Cornelius, Suhel Abbas Sabunwala, Shadi Ghadermarzi, Kartikeya Tripathi, Mark Lazarev, Pin-Jin Hu, Susan Hutfless
AIM: To investigate the differences in family history of inflammatory bowel disease (IBD) and clinical outcomes among individuals with Crohn's disease (CD) residing in China and the United States. METHODS: We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States. We compared the prevalence of IBD family history and history of ileal involvement, CD-related surgeries and IBD medications in China and the United States, adjusting for potential confounders...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27867682/treatment-of-pregnant-women-with-a-diagnosis-of-inflammatory-bowel-disease
#11
REVIEW
Sule Poturoglu, Asli Ciftcibasi Ormeci, Ali Erkan Duman
The frequency of diagnosis of inflammatory bowel disease (IBD) has increased in younger populations. For this reason, pregnancy in patients with IBD is a topic of interest, warranting additional focus on disease management during this period. The main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding stage. Fertility is decreased in patients with active IBD. Disease remission prior to conception will likely decrease the rate of pregnancy-related complications...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27862107/systematic-review-with-meta-analysis-comparative-efficacy-of-immunosuppressants-and-biologics-for-reducing-hospitalisation-and-surgery-in-crohn-s-disease-and-ulcerative-colitis
#12
REVIEW
E J Mao, G S Hazlewood, G G Kaplan, L Peyrin-Biroulet, A N Ananthakrishnan
INTRODUCTION: Crohn's disease (CD) and ulcerative colitis (UC) have a progressive course leading to hospitalisation and surgery. The ability of existing therapies to alter disease course is not clearly defined. AIM: To investigate the comparative efficacy of currently available inflammatory bowel disease (IBD) therapies to reduce hospitalisation and surgery. METHODS: We conducted a systematic review in MEDLINE/PubMed for randomised controlled trials (RCT) published between January 1980 and May 2016 examining efficacy of biological or immunomodulator therapy in IBD...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27856470/thrombosis-in-the-setting-of-obesity-or-inflammatory-bowel-disease
#13
REVIEW
Steven R Lentz
Obesity and inflammatory bowel disease (IBD) are systemic inflammatory disorders that predispose to arterial and venous thrombosis through similar prothrombotic mechanisms. Obesity and IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the thrombotic risk with IBD appears to wax and wane with disease severity. Because of the lack of high-quality evidence to guide management decisions, approaches to the prevention and treatment of thrombosis in patients with obesity or IBD are based on extrapolation from general guidelines for antithrombotic therapy...
November 17, 2016: Blood
https://www.readbyqxmd.com/read/27832710/radiation-exposure-in-patients-with-inflammatory-bowel-disease-and-irritable-bowel-syndrome-in-the-years-2001-2011
#14
Hanna Englund, Katarina Lidén K, Torbjörn Lind, Torbjörn Sundström, Pontus Karling
OBJECTIVES: To compare cumulative ionizing radiation in patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) for the years 2001-2011. To study how radiation exposure change over time in patients with newly diagnosed IBD and factors associated with radiation exposure. MATERIAL AND METHODS: All radiological investigations performed between 1 January 2001 and 31 December 2011 were retrospectively recorded in patients with Crohn's disease (CD) (n = 103), ulcerative colitis (UC) (n = 304) and IBS (n = 149)...
November 10, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27822107/the-danish-national-registry-for-biological-therapy-in-inflammatory-bowel-disease
#15
REVIEW
Lone Larsen, Michael Dam Jensen, Michael Due Larsen, Rasmus Gaardskær Nielsen, Niels Thorsgaard, Ida Vind, Signe Wildt, Jens Kjeldsen
AIM: The aims of The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease are to ensure that biological therapy and the clinical management of patients with inflammatory bowel disease (IBD) receiving biological treatment are in accordance with the national clinical guidelines and, second, the database allows register-based clinical epidemiological research. STUDY POPULATION: The study population comprises all Danish patients with IBD (both children and adults) with ulcerative colitis, Crohn's disease, and IBD unclassified who receive biological therapy...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27799883/surgical-management-of-inflammatory-bowel-disease-in-china-a-systematic-review-of-two-decades
#16
Qiao Yu, Ren Mao, Lei Lian, Siew Chien Ng, Shenghong Zhang, Zhihui Chen, Yanyan Zhang, Yun Qiu, Baili Chen, Yao He, Zhirong Zeng, Shomron Ben-Horin, Xinming Song, Minhu Chen
BACKGROUND/AIMS: The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China. METHODS: We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures...
October 2016: Intestinal Research
https://www.readbyqxmd.com/read/27789943/rna-interference-based-nanosystems-for-inflammatory-bowel-disease-therapy
#17
REVIEW
Jian Guo, Xiaojing Jiang, Shuangying Gui
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic, recrudescent disease that invades the gastrointestinal tract, and it requires surgery or lifelong medicinal therapy. The conventional medicinal therapies for IBD, such as anti-inflammatories, glucocorticoids, and immunosuppressants, are limited because of their systemic adverse effects and toxicity during long-term treatment. RNA interference (RNAi) precisely regulates susceptibility genes to decrease the expression of proinflammatory cytokines related to IBD, which effectively alleviates IBD progression and promotes intestinal mucosa recovery...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27783851/regenerative-potential-of-leucocyte-and-platelet-rich-fibrin-l-prf-part-a-intrabony-defects-furcation-defects-and-periodontal-plastic-surgery-a-systematic-review-and-meta-analysis
#18
REVIEW
Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen
AIM: To analyse the regenerative potential of Leucocyte- and Platelet Rich Fibrin (L-PRF) during periodontal surgery. MATERIALS AND METHODS: An electronic and hand search were conducted in three databases. Only randomised clinical trials were selected and no follow-up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction, and root coverage (%) were considered as outcome. When possible, meta-analysis was performed...
October 26, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27781286/therapeutic-management-of-inflammatory-bowel-disease-in-real-life-practice-in-the-current-era-of-anti-tnf-agents-analysis-of-the-french-administrative-health-databases-2009-2014
#19
J Kirchgesner, M Lemaitre, A Rudnichi, A Racine, M Zureik, F Carbonnel, R Dray-Spira
BACKGROUND: Management of inflammatory bowel disease (IBD) has evolved in the last decade. AIM: To assess IBD therapeutic management, including treatment withdrawal and early treatment use in the current era of anti-TNF agents (anti-TNFs). METHODS: All patients affiliated to the French national health insurance diagnosed with IBD were included from 2009 to 2013 and followed up until 31 December 2014. Medication uses, treatment sequences after introduction of thiopurine or anti-TNF monotherapies or both (combination therapy), surgical procedures and hospitalisations were assessed...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27765687/changing-paradigms-in-detection-of-dysplasia-and-management-of-patients-with-inflammatory-bowel-diseases-is-colectomy-still-necessary
#20
Fernando Velayos, Priya Kathpalia, Emily Finlayson
This review chronicles the evolution of dysplasia detection and management in IBD since 1925, the year the first case report of colitis-related colorectal cancer was published. We have grouped advances in colorectal cancer research, endoscopic techniques, surgery, and technology into 4 unequally timed eras, before colonoscopy, early era of colonoscopy, new century, and 2017 and beyond. We conclude that colorectal cancer prevention and dysplasia management for patients with IBD has changed over these periods, from somewhat hopeless to hopeful...
October 17, 2016: Gastroenterology
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