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Diagnostic tests for fibromyalgia

Patrícia S Cê, Bernardo Bo Barreiro, Rodrigo Bm Silva, Rogério B Oliveira, Claiton Heitz, Maria M Campos
AIMS: To evaluate salivary levels of the proinflammatory cytokine interleukin-1β (IL-1β) in patients with temporomandibular disorders (TMD), fibromyalgia, or both conditions in comparison to healthy individuals. METHODS: A total of 69 females (18 to 84 years of age) were assigned to one of four groups: (A) healthy controls (n = 27); (B) TMD only (n = 18); (C) fibromyalgia only (n = 15); and (D) fibromyalgia plus TMD (n = 9). Clinical data and salivary IL-1β levels were evaluated...
March 21, 2018: Journal of Oral & Facial Pain and Headache
Mette Lodahl, Roi Treister, Anne Louise Oaklander
Introduction: Multiple studies now confirm that ∼40% of patients with fibromyalgia syndrome meet diagnostic criteria for small-fiber polyneuropathy (SFPN) and have objective pathologic or physiologic evidence of SFPN, whereas 60% do not. Given possibilities that tens or hundreds of millions globally could have SFPN, developing screening tools becomes important. Objectives: This analysis explored whether specific symptoms might help distinguish these fibromyalgia endophenotypes...
January 2018: Pain Reports (Baltimore, Md.)
Tom J Crijns, Bonheur A T D van der Gronde, David Ring, Nina Leung
BACKGROUND: Complex regional pain syndrome (CRPS) is frequently diagnosed in patients recovering from surgery or injury. The symptoms and signs included in consensus diagnostic criteria for CRPS are expected after injury. Categorizing symptoms and signs that occur on a continuum as disproportionate or not is subjective and prone to bias. Psychiatrists and psychologists do not diagnose CRPS and instead measure and treat anxiety and catastrophic thinking on its continuum. Given the expected variation in subjective diagnoses such as CRPS, this study addresses factors associated with use of this diagnosis and how it influences care...
February 5, 2018: Clinical Orthopaedics and related Research
Juan Luis Díaz-Cerrillo, Antonio Rondón-Ramos, Susana Clavero-Cano, Rita Pérez-González, Javier Martinez-Calderon, Alejandro Luque-Suarez
OBJECTIVE: To describe some sociodemographics and clinical characteristics of subjects with Non-specific Chronic Low Back Pain (NCLBP) in Primary Care, as well as to investigate their association with Fear-Avoidance (FA). DESIGN: Cross-sectional. Secondary analysis of an intervention study. LOCATION: Basic Health Areas in Costa del Sol Health District (Málaga, Spain). PARTICIPANTS: An analysis was performed on 147 subjects with NCLBP from a previous intervention study database in Primary Care Physiotherapy (PCP)...
January 30, 2018: Atencion Primaria
Toshihide Toriyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo
BACKGROUND: Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressure hyperalgesia determined by a tender point. This study was performed to examine whether: 1) there is a subgroup of episodic migraineurs with widespread pressure hyperalgesia during and between attacks; 2) if such a subgroup exists, what is the prevalence and what is the difference between groups with interictal widespread hyperalgesia and acute allodynia regarding the demographic and clinical characteristics of migraine...
December 28, 2017: Journal of Headache and Pain
Dinesh Kumbhare, Sara Ahmed, Tori Sander, Liza Grosman-Rimon, John Srbely
Objective: In 2010, Wolfe et al. demonstrated poor physician use of the 1990 fibromyalgia diagnostic criteria and proposed the 2010 criteria to address physician shortcomings. No follow-up studies have investigated whether physicians are using these criteria. The purpose of this study was to provide seminal data on physician knowledge and use of the fibromyalgia diagnostic criteria. Methods: This was an observational study. A questionnaire was distributed to a convenience sample of physicians who diagnose chronic pain conditions...
November 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Aleksandar Knezevic, Randy Neblett, Milica Jeremic-Knezevic, Snezana Tomasevic-Todorovic, Ksenija Boskovic, Petar Colovic, Antonio Cuesta-Vargas
OBJECTIVES: It has been increasingly recognized that many chronic pain conditions are associated with central sensitization (CS). The Central Sensitization Inventory (CSI) is a potentially useful tool for screening patients whose presenting symptoms are suspected of being related to CS, so that additional diagnostic evaluation can be performed, and appropriate treatment can be initiated. The original English version is currently not available in Serbian. METHODS: The CSI was translated into Serbian and then psychometrically evaluated in a sample of 363 chronic pain subjects...
August 4, 2017: Pain Practice: the Official Journal of World Institute of Pain
Mareye Voortman, Daan Fritz, Oscar J M Vogels, Filip Eftimov, Diederik van de Beek, Matthijs C Brouwer, Marjolein Drent
PURPOSE OF REVIEW: To discuss cause, clinical manifestations, diagnostics, and treatment of small fiber neuropathy (SFN). The diagnosis is difficult and can be easily missed. RECENT FINDINGS: SFN causes high morbidity with disabling symptoms and impact on quality of life. Patients may benefit from being diagnosed with SFN, even if no underlying cause is identified and no specific treatment is yet available. Recently, genetic mutations as a possible cause of SFN were identified...
September 2017: Current Opinion in Pulmonary Medicine
Thomas Meinertz Dantoft, Jeanette Frost Ebstrup, Allan Linneberg, Sine Skovbjerg, Anja Lykke Madsen, Jesper Mehlsen, Louise Brinth, Lene Falgaard Eplov, Tina Wisbech Carstensen, Andreas Schroder, Per Klausen Fink, Erik Lykke Mortensen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
The Danish study of Functional Disorders (DanFunD) cohort was initiated to outline the epidemiology of functional somatic syndromes (FSS) and is the first larger coordinated epidemiological study focusing exclusively on FSS. FSS are prevalent in all medical settings and can be defined as syndromes that, after appropriate medical assessment, cannot be explained in terms of a conventional medical or surgical disease. FSS are frequent and the clinical importance varies from vague symptoms to extreme disability...
2017: Clinical Epidemiology
Reyhan Celiker, Lale Altan, Aylin Rezvani, Ilknur Aktas, Nurettin Tastekin, Erbil Dursun, Nigar Dursun, Selda Sarıkaya, Senay Ozdolap, Kenan Akgun, Coskun Zateri, Murat Birtane
[Purpose] An easy-to-use, psychometrically validated screening tool for fibromyalgia is needed. This study aims to evaluate the reliability and validity of the Turkish version of the Fibromyalgia Rapid Screening Tool by correlating it with 2013 American College of Rheumatology alternative diagnostic criteria and the Hospital Anxiety and Depression Scale. [Subjects and Methods] Subjects were 269 Physical Medicine and Rehabilitation clinic outpatients. Patients completed a questionnaire including the Fibromyalgia Rapid Screening Tool (twice), 2013 American College of Rheumatology alternative diagnostic criteria, and the Hospital Anxiety and Depression Scale...
February 2017: Journal of Physical Therapy Science
George A Kelley, Kristi S Kelley
PURPOSE: Determine whether evidential value exists that exercise reduces depressive symptoms in adults with arthritis and other rheumatic diseases. METHODS: Using data from a previous meta-analysis of 29 published studies that included 2449 participants (1470 exercise, 979 control) with fibromyalgia, osteoarthritis, rheumatoid arthritis or systemic lupus erythematosus, a novel, recently developed method, p-curve, was used to assess for evidential value and rule out selective reporting of statistically significant findings regarding exercise and depressive symptoms in adults with arthritis and other rheumatic diseases...
May 2016: Medicine and Science in Sports and Exercise
Serge Perrot, Mariana Peixoto, Philippe Dieudé, Eric Hachulla, Jerome Avouac, Sebastien Ottaviani, Yannick Allanore
OBJECTIVES: Fibromyalgia (FM) may occur with rheumatoid arthritis (RA) and systemic sclerosis (SSc), and debate remains about its diagnosis. We aimed to use three FM tools (a screening tool (FiRST), diagnostic criteria (ACR 1990 and revised 2010), to compare FM prevalence between RA and SSc patients, to describe the phenotypes of patients with comorbid FM, and to analyze links between FM and secondary Sjögren's syndrome (SS). METHODS: Consecutive adult patients with confirmed RA or SSc from four university hospitals were tested with the three FM tools...
May 2017: Clinical and Experimental Rheumatology
José V Pardo, Joel T Lee, Robert C Larson, Paul Thuras, Alice A Larson
Increasing recognition of the importance of brown adipose tissue (BAT) motivates the development of reproducible and quantitative methods for measuring it. Positron emission tomography (PET)/computerized tomography (CT) with (18)F-fluorodeoxyglucose (FDG) has become the principal method to non-invasively detect brown adipose tissue (BAT) in humans. Improvements in quantitation and standardization will drive further clinical application. One disorder hypothesized to involve dysregulation in thermoregulation and the processing of pain involving BAT is fibromyalgia syndrome (FMS)...
2017: American Journal of Nuclear Medicine and Molecular Imaging
Winfried Häuser, Jacob Ablin, Serge Perrot, Mary-Ann Fitzcharles
Fibromyalgia (FM) is a prevalent and costly condition worldwide, affecting approximately 2% of the general population. Recent evidence- and consensus‑based guidelines from Canada, Germany, Israel, and the European League Against Rheumatism aim to support physicians in achieving a comprehensive diagnostic workup of patients with chronic widespread (generalized) pain (CWP) and to assist patients and physicians in shared decision making on treatment options. Every patient with CWP requires, at the first medical evaluation, a complete history, medical examination, and some laboratory tests (complete blood count, measurement of C‑reactive protein, serum calcium, creatine phosphokinase, thyroid‑stimulating hormone, and 25‑hydroxyvitamin D levels) to screen for metabolic or inflammatory causes of CWP...
January 4, 2017: Polish Archives of Internal Medicine
Md Abu Bakar Siddiq, Md Shawkat Hossain, Mohammad Moin Uddin, Israt Jahan, Moshiur Rahman Khasru, Neaz Mahmud Haider, Johannes J Rasker
AIMS: To describe a series of piriformis syndrome patient among Bangladesh people with literature review. METHODS: Consecutive 31 piriformis syndrome patients were enrolled. Besides history and clinical examination, piriformis muscle thickness was also measured with diagnostic ultrasound (3.5 MHZ). MRI of lumbar spine, X-rays of lumbo-sacral spine, and pelvis were performed in all patients. Statistical Package for the Social Sciences (SPSS), Windows 8.0, was used for statistical calculation, and univariate analysis of primary data was done...
February 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Michél Rathbone, William Parkinson, Yasir Rehman, Shucui Jiang, Mohit Bhandari, Dinesh Kumbhare
OBJECTIVES AND METHODS: A systematic review and meta-analysis were performed to estimate the size and variability of the association between chronic pain (CP) and poorer cognitive test performances as a function of individual tests, pain sub-types, and study sources on 22 studies having (1) a control group, (2) reported means and standard deviations (SDs) and (3) tests studied at least 3 times. RESULTS: CP patients performed significantly poorer with small to moderate effects (d = -...
August 2016: British Journal of Pain
L B Campi, P C Jordani, H L Tenan, C M Camparis, D A G Gonçalves
The objective was to investigate the presence of cutaneous allodynia and hyperalgesia in the trigeminal and extra-trigeminal areas, as a surrogate for central sensitization (CS), in women with a painful temporomandibular disorder (TMD) and without other painful conditions. Painful TMDs, depression, and non-specific physical symptoms (NSPS) were classified according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). The amount of pain in the trigeminal and extra-trigeminal areas was determined using a visual analogue scale (0-100mm) after the application of a vibrotactile stimulus and assessment of the pressure pain threshold (PPT)...
January 2017: International Journal of Oral and Maxillofacial Surgery
George A Kelley, Kristi S Kelley
AIM: To determine whether evidential value exists that exercise reduces depression in adults with arthritis and other rheumatic conditions. METHODS: Utilizing data derived from a prior meta-analysis of 29 randomized controlled trials comprising 2449 participants (1470 exercise, 979 control) with fibromyalgia, osteoarthritis, rheumatoid arthritis or systemic lupus erythematosus, a new method, P-curve, was utilized to assess for evidentiary worth as well as dismiss the possibility of discriminating reporting of statistically significant results regarding exercise and depression in adults with arthritis and other rheumatic conditions...
July 12, 2016: World Journal of Rheumatology
Helen J Burgess, Margaret Park, Jason C Ong, Najia Shakoor, David A Williams, John Burns
Objective: To test the feasibility, acceptability, and effects of a home-based morning versus evening bright light treatment on function and pain sensitivity in women with fibromyalgia. Design: A single blind randomized study with two treatment arms: 6 days of a 1 hour morning light treatment or 6 days of a 1 hour evening light treatment. Function, pain sensitivity, and circadian timing were assessed before and after treatment. Setting: Participants slept at home, except for two nights in Sleep Center...
January 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Kim D Jones, Terri Gelbart, Thomas C Whisenant, Jill Waalen, Tony S Mondala, David N Iklé, Daniel R Salomon, Robert M Bennett, Sunil M Kurian
OBJECTIVES: Fibromyalgia (FM) is a common pain disorder characterized by nociceptive dysregulation. The basic biology of FM is poorly understood. Herein we have used agnostic gene expression as a potential probe for informing its underlying biology and the development of a proof-of-concept diagnostic gene expression signature. METHODS: We analyzed RNA expression in 70 FM patients and 70 healthy controls. The isolated RNA was amplified and hybridized to Affymetrix® Human Gene 1...
March 2016: Clinical and Experimental Rheumatology
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