keyword
MENU ▼
Read by QxMD icon Read
search

calcitriol

keyword
https://www.readbyqxmd.com/read/27919940/vitamin-d-and-myofibroblasts-in-fibrosis-and-cancer-at-cross-purposes-with-tgf-%C3%AE-smad-signaling
#1
REVIEW
Shraga Shany, Ina Sigal-Batikoff, Sergio Lamprecht
The multifaceted involvement of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 (henceforth referred to by the synonyms 1,25(OH)2D3, calcitriol or vitamin D) in blunting the growth of cancer cells is amply recognized. In this review we focused our attention on the cross-talk between 1,25 (OH)2D3 and the tumor microenvironment (TME), signaling out stromal cancer-associated fibroblasts (CAFs), the most abundant TME population, as a target for calcitriol anticancer action. In view of the commonality of the phenotypic signature in myofibroblasts, resident in the cancer stroma and in non-neoplastic fibrotic loci, we examined modes of action of vitamin D in non-neoplastic chronic diseases and in cancer to assess mechanistic similarities and divergences...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919743/dual-antiplasmodial-activity-of-vitamin-d3-and-its-analog-22-oxacalcitriol-by-direct-and-indirect-mechanisms
#2
Kiichi Yamamoto, Moritoshi Iwagami, Takenori Seki, Shigeyuki Kano, Nobuo Ota, Manabu Ato
Recent evidence suggests that 1α,25-dihydroxyvitamin D3 (calcitriol, VD3), the active form of vitamin D (VD), can inhibit the proliferation of microorganisms. In the present study, we conducted in vitro experiments and utilized in vivo murine models to investigate the antimalarial activity of VD3 and its analog, 22-oxacalcitriol (22-OCT), which was designed to cause less hypercalcemia than VD3. VD3 and 22-OCT treatments effectively resolved a Plasmodium chabaudi (Pc) infection in wild-type mice. Reduced parasitemia was observed during the acute phase of infection in the presence of VD3 and 22-OCT, followed by a delayed peak during the chronic stage of infection...
December 2, 2016: Parasitology International
https://www.readbyqxmd.com/read/27903853/intraperitoneal-calcitriol-for-treatment-of-severe-hyperparathyroidism-in-children-with-chronic-kidney-disease-a-therapy-forgotten
#3
Rahul Chanchlani, Susan Ackerman, Elizabeth Piva, Elizabeth Harvey
Active Vitamin D sterols such as calcitriol and alfacalcidol are quite effective in the treatment of mineral bone disease secondary to chronic kidney disease. However, some children on peritoneal dialysis (PD) are resistant to oral formulations of active Vitamin D, and use of an intravenous formulation in such patients is inconvenient. In these children, intraperitoneal (IP) calcitriol has been shown to be effective in the treatment of secondary hyperparathyroidism. However, its use has declined. We report 2 children, aged 1 and 9...
November 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27902981/calcitriol-reduces-eosinophil-necrosis-which-leads-to-the-diminished-release-of-cytotoxic-granules
#4
Caroline Ethier, Yingqi Yu, Lisa Cameron, Paige Lacy, Francis Davoine
BACKGROUND: Asthma severity and eosinophilia correlate with a deficiency in vitamin D and its active metabolite calcitriol. Calcitriol modulates numerous leukocyte functions, but its effect on eosinophils is not fully understood. We postulated that calcitriol exerts a direct effect on eosinophil biology by modulating cell survival. METHODS: Purified peripheral blood eosinophils from atopic donors were incubated in the presence of calcitriol for up to 14 days with or without IL-5...
December 1, 2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27900938/calcitriol-in-the-treatment-of-iga-nephropathy-with-non-nephrotic-range-proteinuria-a-meta-analysis-of-randomized-controlled-trials%C3%A2
#5
Jin Deng, Xin Zheng, Hongping Xie, Lu Chen
OBJECTIVE: The aim of the present study was to investigate the efficacy and safety of calcitriol for treating Chinese patients with IgA nephropathy presenting as non-nephrotic range proteinuria, and a comprehensive meta-analysis was conducted using the related randomized controlled trials (RCTs). METHODS: We searched for RCTs of calcitriol for the treatment of IgA nephropathy in the CNKI, CBM, Cochrane Central Register of Controlled Trials, PUBMED, and EMBASE databases...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27897610/effect-of-calcitriol-supplementation-on-blood-pressure-in-older-adults
#6
Jaime Alberto Bricio-Barrios, Alín Jael Palacios-Fonseca, Mario Del Toro-Equihua, Carmen Alicia Sanchez-Ramirez
Recent studies suggest that vitamin D plays an important role in the control of blood pressure. Unfortunately, because older adults are more likely to have low 25-hydroxyvitamin-D [25(OH)D] levels, this study investigated whether calcitriol supplementation reduces blood pressure in older adults with hypertension. The design was a double-blind placebo-controlled randomized clinical trial with 36 randomly assigned subjects (71.7 ± 10 years). Blood pressure and serum levels of 25(OH)D before and after calcitriol intervention (1,000 IU daily for 6 weeks; n = 22) or placebo (n = 23) for 6 weeks were analyzed...
October 2016: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27897272/analysis-of-the-interaction-of-calcitriol-with-the-disulfide-isomerase-erp57
#7
Elisa Gaucci, Domenico Raimondo, Caterina Grillo, Laura Cervoni, Fabio Altieri, Giulio Nittari, Margherita Eufemi, Silvia Chichiarelli
Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane-associated receptor, which has been discovered as the disulfide isomerase ERp57. The aim of our research is to identify the binding sites for calcitriol in ERp57 and to analyze their interaction. We first studied the interaction through bioinformatics and fluorimetric analyses. Subsequently, we focused on two protein mutants containing the predicted interaction domains with calcitriol: abb'-ERp57, containing the first three domains, and a'-ERp57, the fourth domain only...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27888144/calcifediol-loaded-liposomes-for-local-treatment-of-pulmonary-bacterial-infections
#8
Arianna Castoldi, Christian Herr, Julia Niederstraßer, Hagar Ibrahim Labouta, Ana Melero, Sarah Gordon, Nicole Schneider-Daum, Robert Bals, Claus-Michael Lehr
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%...
November 22, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27879271/vitamin-d3-prevents-calcium-induced-progression-of-early-stage-prostate-tumors-by-counteracting-trpc6-and-calcium-sensing-receptor-upregulation
#9
Sophie Bernichtein, Natascha Pigat, Nicolas Barry Delongchamps, Florence Boutillon, Virginie Verkarre, Philippe Camparo, Edouard Reyes-Gomez, Arnaud Méjean, Stephane Marie Oudard, Eve M Lepicard, Melanie Viltard, Jean-Claude Souberbielle, Gerard Friedlander, Thierry Capiod, Vincent Goffin
Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that faciliate progression to more aggressive stages is critical for disease prevention. Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impact on early-stage tumors remains unexplored. In this study, we addressed this issue with a large interventional animal study. Mouse models of fully penetrant and slowly-evolving prostate tumorigenesis showed that a high calcium diet dramatically accelerated the progression of prostate intraepithelial neoplasia, by promoting cell proliferation, micro-invasion, tissue inflammation and expression of acknowledged prostate cancer markers...
November 22, 2016: Cancer Research
https://www.readbyqxmd.com/read/27871977/a-time-course-regulatory-and-kinetic-expression-study-of-steroid-metabolizing-enzymes-by-calcitriol-in-primary-cultured-human-placental-cells
#10
Nancy Noyola-Martínez, Ali Halhali, Verónica Zaga-Clavellina, Andrea Olmos-Ortiz, Fernando Larrea, David Barrera
1,25-dihydroxivitamin D3 (calcitriol), is a secoesteroid involved in several placental functions. In particular, we and others showed that calcitriol regulates peptides, proteins, cytokines and hormones production in human trophoblastic cells. On the other hand, calcitriol modifies the activity and expression of some steroidogenic enzymes, a process that is considered tissue-specific. However, the effects of calcitriol on the expression of enzymes involved in the synthesis of sex steroids in placental tissue have not yet been entirely studied...
November 18, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27866217/osteonecrosis-of-the-jaw-onj-and-atypical-femoral-fracture-aff-in-an-osteoporotic-patient-chronically-treated-with-bisphosphonates
#11
A Sánchez, R Blanco
The aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87 years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999-2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006-2008). She received occasional supplements of ergocalciferol...
November 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27857805/neuropsychiatric-phenotype-in-a-child-with-pseudohypoparathyroidism
#12
Paola Visconti, Annio Posar, Maria Cristina Scaduto, Angelo Russo, Federica Tamburrino, Laura Mazzanti
Pseudohypoparathyroidism (PHP) is a rare heterogeneous genetic disease characterized by end-organ resistance to parathyroid hormone. In adulthood, heterogeneous neurological and psychiatric disorders have been reported which are associated with hypoparathyroidism in general and with PHP in particular, while for childhood, data are scanty. We report a case of a boy with PHP type 1b, in whom neurological signs at the onset prevailed, characterized by tic-like dyskinesias associated with a series of heterogeneous not well-defined neurological and behavioral features, describing the diagnostic work-up performed and the follow-up...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27832822/sarcoidosis-presenting-as-granulomatous-myositis-in-a-16-year-old-adolescent
#13
Amir B Orandi, Eric Eutsler, Cole Ferguson, Andrew J White, Maleewan Kitcharoensakkul
BACKGROUND: Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle. These organized collections of immune cells have important pathophysiologic action including cytokine production leading to inflammation as well as enzymatic conversion of cholecalciferol to calcitriol via 1-α hydroxylase. There are limited reports of isolated granulomatous myositis causing hypercalcemia in pediatric patients...
November 10, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27832772/calcitriol-stimulates-gene-expression-of-cathelicidin-antimicrobial-peptide-in-breast-cancer-cells-with-different-phenotype
#14
Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, Euclides Avila, Fernando Larrea, Lorenza Díaz
BACKGROUND: In normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial peptide (CAMP). Nevertheless, little is known about the factors regulating this peptide expression in breast cancer. Herein we asked if the well-known antineoplastic hormone calcitriol could differentially modulate CAMP gene expression in human breast cancer cells depending on the cell phenotype in terms of efficacy and potency...
November 10, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27828582/-factors-associated-with-the-frailty-of-elderly-people-with-chronic-kidney-disease-on-hemodialysis
#15
Gabriela Dutra Gesualdo, Marisa Silvana Zazzetta, Karina Gramani Say, Fabiana de Souza Orlandi
The scope of this article is to identify sociodemographic and clinical factors associated with the frailty of elderly people with chronic kidney disease on hemodialysis. This involved a correlational, cross-sectional study conducted in a dialysis center in the state of São Paulo. The sample consisted of 60 participants. The Participant Characterization Instrument was used for extracting sociodemographic and clinical data and the Edmonton Frail Scale was used to evaluate the level of frailty. Multivariate logistic regression was used to identify the factors associated with frailty...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27822674/conversion-of-oral-alfacalcidol-to-oral-calcitriol-in-the-treatment-of-secondary-hyperparathyroidism-in-chronic-hemodialysis-patients
#16
Sandrine Rauscher, Jean-Philippe Lafrance, Vincent Pichette, Robert Z Bell, Katherine Desforges, Laurence Lepage, Georges Ouellet, Denis Ouimet, Martine Leblanc, Caroline Lamarche, Sarah Bezzaoucha, Michel Vallee
PURPOSE: The optimal vitamin D3 therapy for the treatment of secondary hyperparathyroidism (SHPT) in chronic hemodialysis patients is still controversial. Recent studies suggest that uremia in end-stage renal disease is associated with enzymatic hepatic dysfunction altering 25-hydroxylation of vitamin D3. The goal of our study was to compare the efficacy of calcitriol, the fully hydroxylated active form of vitamin D3, to alfacalcidol which needs 25-hydroxylation to be effective, for the treatment of SHPT in chronic hemodialysis patients...
November 8, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27820122/tumor-induced-osteomalacia-in-a-3-year-old-with-unresectable-central-giant-cell-lesions
#17
Stephanie S Crossen, Eduardo Zambrano, Beverley Newman, Jonathan A Bernstein, Anna H Messner, Laura K Bachrach, Clare J Twist
Tumor-induced osteomalacia (TIO) is a rare cause of hypophosphatemia involving overproduction of fibroblast growth factor 23. TIO has been described largely in adults with small mesenchymal tumors. We report a case of TIO in a child who presented with knee pain and radiographic findings concerning for rickets, and was found to have maxillomandibular giant cell lesions. The patient was treated with oral phosphorus and calcitriol, surgical debulking, and intralesional corticosteroids, which resulted in tumor regression and normalization of serum fibroblast growth factor 23and phosphorus...
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27818783/plasma-calcidiol-calcitriol-and-parathyroid-hormone-and-risk-of-new-onset-heart-failure-in-a-population-based-cohort-study
#18
Laura M G Meems, Frank P Brouwers, Michel M Joosten, Hiddo J Lambers Heerspink, Dick de Zeeuw, Stephan J L Bakker, Ron T Gansevoort, Wiek H van Gilst, Pim van der Harst, Rudolf A de Boer
BACKGROUND: Heart failure (HF) is a major problem in the Western world, with increasing prevalence and incidence. Because HF cannot be cured, prevention of HF is of utter importance. Calcidiol, calcitriol, and parathyroid hormone (PTH) have been identified as risk factors for cardiovascular disease. However, their association with new onset HF remains to be established. We investigated whether calcidiol, calcitriol, and PTH could be used to identify those subjects at risk for new onset HF, and if they had additive predictive value over established risk predictors like N-terminal-pro Brain-type natriuretic peptide and highly sensitive Troponin-T...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27813709/serum-1-25-dihydroxyvitamin-d-as-a-biomarker-of-the-absence-of-hypercalciuria-in-postsurgical-hypoparathyroidism
#19
Luis García-Pascual, María José Barahona, Verónica Perea, Rafael Simó
CONTEXT: Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment which can lead to renal complications. The collection of 24-hour urine to detect hypercalciuria is often considered unreliable. OBJECTIVE: To find useful predictive biomarkers of hypercalciuria in patients with permanent postsurgical hypoparathyroidism under treatment with oral calcium and calcitriol supplements. DESIGN: Prospective cross-sectional study...
November 4, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27813050/long-term-follow-up-and-treatment-of-postoperative-permanent-hypoparathyroidism-in-patients-with-medullary-thyroid-carcinoma-differences-in-complete-and-partial-disease
#20
G Leidig-Bruckner, T Bruckner, F Raue, K Frank-Raue
This study aimed to identify factors influencing long-term outcome in complete or partial postoperative hypoparathyroidism (parathyroid hormone ≤10 or >10 ng/l, respectively) in medullary thyroid carcinoma (MTC). It was designed as retrospective, long-term follow-up with single-center outpatient visits. Quality of treatment, renal calcification, and function were evaluated. In 33 patients with MTC and postoperative hypoparathyroidism, current medication includes: calcium (73%), calcitriol (73%), alfacalcidol (6%), dihydrotachysterol (3%), and cholecalciferol supplements (21%)...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
keyword
keyword
60842
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"