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https://www.readbyqxmd.com/read/28227630/an-rf-powering-system-with-adaptive-impedance-matching-for-individual-health-monitoring-applications
#1
Zemin Liu, Yu-Pin Hsu, Mona M Hella, Zemin Liu, Yu-Pin Hsu, Mona M Hella, Yu-Pin Hsu, Mona M Hella, Zemin Liu
This paper presents a high-efficiency RF powering system, suitable for individual health monitoring applications. The system is composed of an antenna, an impedance matching network, and a two-stage full-wave RF-DC rectifier. A novel tuning mechanism is proposed to automatically adjust the impedance of the matching network. This mechanism can effectively improve the power efficiency of the system by 47% compared to the case without tuning. For the adaptive impedance, only a 5-bits binary weighted capacitor bank is required in the matching network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227347/an-eemd-pca-approach-to-extract-heart-rate-respiratory-rate-and-respiratory-activity-from-ppg-signal
#2
Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami, Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami, Marimuthu Palaniswami, Mohammod Abdul Motin, Chandan Kumar Karmakar
The pulse oximeter's photoplethysmographic (PPG) signals, measure the local variations of blood volume in tissues, reflecting the peripheral pulse modulated by cardiac activity, respiration and other physiological effects. Therefore, PPG can be used to extract the vital cardiorespiratory signals like heart rate (HR), respiratory rate (RR) and respiratory activity (RA) and this will reduce the number of sensors connected to the patient's body for recording vital signs. In this paper, we propose an algorithm based on ensemble empirical mode decomposition with principal component analysis (EEMD-PCA) as a novel approach to estimate HR, RR and RA simultaneously from PPG signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226493/towards-an-unsupervised-device-for-the-diagnosis-of-childhood-pneumonia-in-low-resource-settings-automatic-segmentation-of-respiratory-sounds
#3
J Sola, F Braun, E Muntane, C Verjus, M Bertschi, F Hugon, S Manzano, M Benissa, A Gervaix, J Sola, F Braun, E Muntane, C Verjus, M Bertschi, F Hugon, S Manzano, M Benissa, A Gervaix, F Hugon, C Verjus, A Gervaix, S Manzano, M Bertschi, E Muntane, M Benissa, J Sola, F Braun
Pneumonia remains the worldwide leading cause of children mortality under the age of five, with every year 1.4 million deaths. Unfortunately, in low resource settings, very limited diagnostic support aids are provided to point-of-care practitioners. Current UNICEF/WHO case management algorithm relies on the use of a chronometer to manually count breath rates on pediatric patients: there is thus a major need for more sophisticated tools to diagnose pneumonia that increase sensitivity and specificity of breath-rate-based algorithms...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225837/storage-time-of-intraoperative-transfused-allogeneic-red-blood-cells-is-not-associated-with-new-onset-postoperative-atrial-fibrillation-in-cardiac-surgery
#4
Jiwei Gu, Regitze Kuhr Skals, Christian Torp-Pedersen, Søren Lundbye-Christensen, Carl-Johan Jakobsen, John Bæch, Mikkel Steen Petersen, Jan Jesper Andreasen
BACKGROUND: Allogeneic red blood cell (RBC) transfusion has been associated with new-onset postoperative atrial fibrillation (POAF) following cardiac surgery. Prolonged storage time of RBC may increase the risk. The primary aim of the study was to evaluate whether the storage time of RBC is associated with development of POAF. MATERIALS AND METHODS: Pre-, per- and postoperative data were retrieved from the Western Denmark Heart Registry and local blood banks regarding patients who underwent coronary artery bypass surgery, valve surgery or combined procedures in Aalborg or Aarhus University Hospital during 2010-2014...
2017: PloS One
https://www.readbyqxmd.com/read/28225828/systematic-analysis-of-non-structural-protein-features-for-the-prediction-of-ptm-function-potential-by-artificial-neural-networks
#5
Henry M Dewhurst, Matthew P Torres
Post-translational modifications (PTMs) provide an extensible framework for regulation of protein behavior beyond the diversity represented within the genome alone. While the rate of identification of PTMs has rapidly increased in recent years, our knowledge of PTM functionality encompasses less than 5% of this data. We previously developed SAPH-ire (Structural Analysis of PTM Hotspots) for the prioritization of eukaryotic PTMs based on function potential of discrete modified alignment positions (MAPs) in a set of 8 protein families...
2017: PloS One
https://www.readbyqxmd.com/read/28225797/use-of-bovine-recombinant-prion-protein-and-real-time-quaking-induced-conversion-to-detect-cattle-transmissible-mink-encephalopathy-prions-and-discriminate-classical-and-atypical-l-and-h-type-bovine-spongiform-encephalopathy
#6
Soyoun Hwang, Justin J Greenlee, Eric M Nicholson
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc). This conversion has been used for in vitro assays including serial protein misfolding amplification and real-time quaking induced conversion (RT-QuIC). RT-QuIC can be used for the detection of prions in a variety of biological tissues from humans and animals. Extensive work has been done to demonstrate that RT-QuIC is a rapid, specific, and highly sensitive prion detection assay...
2017: PloS One
https://www.readbyqxmd.com/read/28225788/molecular-detection-and-genotyping-of-enteroviruses-from-csf-samples-of-patients-with-suspected-sepsis-like-illness-and-or-aseptic-meningitis-from-2012-to-2015-in-west-bank-palestine
#7
Kamal Dumaidi, Amer Al-Jawabreh
BACKGROUND: Human enteroviruses (HEVs) are the most frequently reported cause of aseptic meningitis with or without CSF pleocytosis in childhood. Rapid detection and genotype of HEVs is essential to determine the causative agent and variant causing sepsis-like illness and/or aseptic meningitis. AIM: To investigate the molecular epidemiology of enteroviruses (EVs) among patients with sepsis-like illness and/or aseptic meningitis admitted to three major hospitals in West Bank, Palestine from 2012 to 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28225464/beyond-selection-the-use-of-situational-judgement-tests-in-the-teaching-and-assessment-of-professionalism
#8
Barbara D Goss, Anna T Ryan, Joshua Waring, Terry Judd, Neville G Chiavaroli, Richard Charles O'Brien, Stephen C Trumble, Geoffrey J McColl
PROBLEM: Professionalism is a critical attribute of medical graduates. Its measurement is challenging. The authors sought to assess final-year medical students' knowledge of appropriate professional behavior across a broad range of workplace situations. APPROACH: Situational judgement tests (SJTs) are used widely in applicant selection to assess judgement or decision making in work-related settings as well as attributes such as empathy, integrity, and resilience...
February 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28224926/a-30-month-worksite-based-lifestyle-program-to-promote-cardiovascular-health-in-middle-aged-bank-employees-design-of-the-tansnip-pesa-randomized-controlled-trial
#9
Jennifer K Coffeng, Hidde P van der Ploeg, José M Castellano, Juan M Fernández-Alvira, Borja Ibáñez, Inés García-Lunar, Allard J van der Beek, Antonio Fernández-Ortiz, Agustín Mocoroa, Laura García-Leal, Evelyn Cárdenas, Carolina Rojas, María I Martínez-Castro, Silvia Santiago-Sacristán, Miriam Fernández-Gallardo, José M Mendiguren, Sameer Bansilal, Willem van Mechelen, Valentín Fuster
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death worldwide. With atherosclerosis as the underlying cause for many CVD events, prevention or reduction of subclinical atherosclerotic plaque burden (SAPB) through a healthier lifestyle may have substantial public health benefits. OBJECTIVE: The objective was to describe the protocol of a randomized controlled trial investigating the effectiveness of a 30-month worksite-based lifestyle program aimed to promote cardiovascular health in participants having a high or a low degree of SAPB compared with standard care...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28224488/hmms-in-protein-fold-classification
#10
Christos Lampros, Costas Papaloukas, Themis Exarchos, Dimitrios I Fotiadis
The limitation of most HMMs is their inherent high dimensionality. Therefore we developed several variations of low complexity models that can be applied even to protein families with a few members. In this chapter we present these variations. All of them include the use of a hidden Markov model (HMM), with a small number of states (called reduced state-space HMM), which is trained with both amino acid sequence and secondary structure of proteins whose 3D structure is known and it is used for protein fold classification...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28224257/differential-item-functioning-of-the-patient-reported-outcomes-information-system-promis-%C3%A2-pain-interference-item-bank-by-language-spanish-versus-english
#11
Sylvia H Paz, Karen L Spritzer, Steven P Reise, Ron D Hays
BACKGROUND: About 70% of Latinos, 5 years old or older, in the United States speak Spanish at home. Measurement equivalence of the PROMIS(®) pain interference (PI) item bank by language of administration (English versus Spanish) has not been evaluated. METHODS: A sample of 527 adult Spanish-speaking Latinos completed the Spanish version of the 41-item PROMIS(®) pain interference item bank. We evaluate dimensionality, monotonicity and local independence of the Spanish-language items...
February 21, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28224081/rna-seq-analysis-of-human-cell-lines-established-from-normal-and-neoplastic-esophageal-squamous-epithelium
#12
Ichiro Akagi, Osamu Ishibashi
Esophageal cancer (EC) is the eighth most common cancer globally in 2012 and predominantly occurs in the man (Enzinger and Mayer, 2003; Conteduca et al., 2012). EC is classified mainly into two types, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma, accounting for 60-70% and 20-30% of all EC cases, respectively. In a previous statistical study it was reported that the numbers of new EC cases and EC-related deaths worldwide in 2008 were estimated to be 482,300 and 406,800, respectively (Jemal et al...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28223062/nivolumab-for-previously-treated-unresectable-metastatic-anal-cancer-nci9673-a-multicentre-single-arm-phase-2-study
#13
Van K Morris, Mohamed E Salem, Halla Nimeiri, Syma Iqbal, Preet Singh, Kristen Ciombor, Blase Polite, Dustin Deming, Emily Chan, James L Wade, Lianchun Xiao, Tanios Bekaii-Saab, Luis Vence, Jorge Blando, Armeen Mahvash, Wai Chin Foo, Chimela Ohaji, Manolo Pasia, Gail Bland, Aki Ohinata, Jane Rogers, Amir Mehdizadeh, Kimberly Banks, Richard Lanman, Robert A Wolff, Howard Streicher, James Allison, Padmanee Sharma, Cathy Eng
BACKGROUND: Squamous cell carcinoma of the anal canal (SCCA) is a rare malignancy associated with infection by human papillomavirus (HPV). No consensus treatment approach exists for the treatment of metastatic disease. Because intratumoral HPV oncoproteins upregulate immune checkpoint proteins such as PD-1 to evade immune-mediated cytotoxicity, we did a trial of the anti-PD-1 antibody nivolumab for patients with metastatic SCCA. METHODS: We did this single-arm, multicentre, phase 2 trial at ten academic centres in the USA...
February 17, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28223040/red-blood-cell-exchange-as-an-approach-for-treating-a-case-of-severe-tacrolimus-overexposure
#14
Valentina Spallanzani, Lucia Bindi, Irene Bianco, Arianna Precisi, Paolo DeSimone, Alessandro Mazzoni, Gianni Biancofiore
Immunosuppressive medication dosing errors are not unfrequent and may present a number of challenges to transplant clinicians. Tacrolimus (TAC) is a widely used immunosuppressant with a narrow therapeutic index and potential severe side effects, including neurotoxicity and kidney injury. We herein report a case of 60-year-old woman who underwent deceased-donor liver transplantation at our center and due to inadvertent TAC overexposure was admitted to the Intensive Care Unit because of severe neurologic impairment, kidney injury and arterial hypotension...
February 2, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28222915/comparison-of-modified-kampala-trauma-score-with-trauma-mortality-prediction-model-and-trauma-injury-severity-score-a-national-trauma-data-bank-study
#15
Serhat Akay, Ahmet Mucteba Ozturk, Huriye Akay
BACKGROUND: Mortality prediction of trauma patients relies on anatomical, physiological or combined scores. The purpose of this study is to compare the diagnostic accuracy of the modified Kampala Trauma Score (M-KTS) with the Trauma Mortality Prediction Model (TMPM), and Trauma-Injury Severity Score (TRISS) using data from a large dataset from a developed registry, the National Trauma Data Bank (NTDB). METHODS: Using 2011 and 2012 data from NTDB, patient based trauma scores (M-KTS, TMPM, and TRISS) were calculated and predictive ability of M-KTS for mortality was compared with other trauma scores using receiver operating characteristics (ROC) curves...
February 16, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28222911/store-operated-ca-2-entry-is-not-required-for-fertilization-induced-ca-2-signaling-in-mouse-eggs
#16
Miranda L Bernhardt, Elizabeth Padilla-Banks, Paula Stein, Yingpei Zhang, Carmen J Williams
Repetitive oscillations in cytoplasmic Ca(2+) due to periodic Ca(2+) release from the endoplasmic reticulum (ER) drive mammalian embryo development following fertilization. Influx of extracellular Ca(2+) to support the refilling of ER stores is required for sustained Ca(2+) oscillations, but the mechanisms underlying this Ca(2+) influx are controversial. Although store-operated Ca(2+) entry (SOCE) is an appealing candidate mechanism, several groups have arrived at contradictory conclusions regarding the importance of SOCE in oocytes and eggs...
February 11, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28222686/ipsiversive-ictal-eye-deviation-in-inferioposterior-temporal-lobe-epilepsy-two-seeg-cases-report
#17
Wei Zhang, Xingzhou Liu, Lijun Zuo, Qiang Guo, Qi Chen, Yongjun Wang
BACKGROUND: Versive seizure characterized by conjugate eye movement during epileptic seizure has been considered commonly as one of the most valuable semiological signs for epilepsy localization, especially for frontal lobe epilepsy. However, thelateralizing and localizing significance of ictaleye deviation has been questioned by clinical observation of a series of focal epilepsy studies, including frontal, central, temporal, parietal and occipital epilepsy. CASE PRESENTATION: Two epileptic cases characterized by ipsiversive eye deviation as initial clinical sign during the habitual epileptic seizures are presented in this paper...
February 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28222522/intranasal-insulin-transport-is-preserved-in%C3%A2-aged-samp8-mice-and-is-altered-by-albumin-and-insulin-receptor-inhibition
#18
Elizabeth M Rhea, Samantha R Humann, Surabhi Nirkhe, Susan A Farr, John E Morley, William A Banks
Insulin delivered to the level of the cribriform plate (intranasal insulin) is being investigated for its ability to enhance memory in people with Alzheimer's disease (AD). Recent work has shown intranasal insulin can be detected in young CD-1 mice within 5 min and is still present 60 min after injection. The current study determined whether intranasal insulin transport and the subsequent brain distribution of insulin varies in young, healthy mice (CD-1) compared to those with an AD-like phenotype (aged SAMP8) or those pre-disposed to develop such a phenotype (young SAMP8)...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28220788/no3-anions-can-act-as-lewis-acid-in-the-solid-state
#19
Antonio Bauzá, Antonio Frontera, Tiddo J Mooibroek
Identifying electron donating and accepting moieties is crucial to understanding molecular aggregation, which is of pivotal significance to biology. Anions such as NO3(-) are typical electron donors. However, computations predict that the charge distribution of NO3(-) is anisotropic and minimal on nitrogen. Here we show that when the nitrate's charge is sufficiently dampened by resonating over a larger area, a Lewis acidic site emerges on nitrogen that can interact favourably with electron rich partners. Surveys of the Cambridge Structural Database and Protein Data Bank reveal geometric preferences of some oxygen and sulfur containing entities around a nitrate anion that are consistent with this 'π-hole bonding' geometry...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28220575/generation-of-storable-retinal-organoids-and-retinal-pigmented-epithelium-from-adherent-human-ips-cells-in-xeno-free-and-feeder-free-conditions
#20
Sacha Reichman, Amélie Slembrouck, Giuliana Gagliardi, Antoine Chaffiol, Angélique Terray, Céline Nanteau, Anais Potey, Morgane Belle, Oriane Rabesandratana, Jens Duebel, Gael Orieux, Emeline F Nandrot, José-Alain Sahel, Olivier Goureau
Human induced pluripotent stem cells (hiPSCs) are potentially useful in regenerative therapies for retinal disease. For medical applications, therapeutic retinal cells, such as retinal pigmented epithelial (RPE) cells or photoreceptor precursors, must be generated under completely defined conditions. To this purpose, we have developed a two-step xeno-free/feeder-free (XF/FF) culture system to efficiently differentiate hiPSCs into retinal cells. This simple method, relies only on adherent hiPSCs cultured in chemically defined media, bypassing embryoid body formation...
February 20, 2017: Stem Cells
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