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https://www.readbyqxmd.com/read/28636235/stem-cell-based-tooth-and-periodontal-regeneration
#1
Lei Hu, Yi Liu, Songlin Wang
Currently regeneration of tooth and periodontal damage still remains great challenge. Stem cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem cells for tooth and periodontal regeneration include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from the dental apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), dental epithelial stem cells (DESCs), bone marrow mesenchymal stem cells (BMMSCs), adipose-derived stem cells (ADSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
June 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28635334/timing-of-food-intake-during-simulated-night-shift-impacts-glucose-metabolism-a-controlled-study
#2
Crystal L Grant, Alison M Coates, Jillian Dorrian, David J Kennaway, Gary A Wittert, Leonie K Heilbronn, Maja Pajcin, Chris Della Vedova, Charlotte C Gupta, Siobhan Banks
Eating during the night may increase the risk for obesity and type 2 diabetes in shift workers. This study examined the impact of either eating or not eating a meal at night on glucose metabolism. Participants underwent four nights of simulated night work (SW1-4, 16:00-10:00 h, <50 lux) with a daytime sleep opportunity each day (10:00-16:00 h, <3 lux). Healthy males were assigned to an eating at night (NE; n = 4, meals; 07:00, 19:00 and 01:30 h) or not eating at night (NEN; n = 7, meals; 07:00 h, 09:30, 16:10 and 19:00 h) condition...
June 21, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28634413/topical-fibronectin-improves-wound-healing-of-irradiated-skin
#3
Maxwell B Johnson, Brandon Pang, Daniel J Gardner, Solmaz Niknam-Benia, Vinaya Soundarajan, Athanasios Bramos, David P Perrault, Kian Banks, Gene K Lee, Regina Y Baker, Gene H Kim, Sunju Lee, Yang Chai, Mei Chen, Wei Li, Lawrence Kwong, Young-Kwon Hong, Alex K Wong
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633337/differences-in-below-ground-bud-bank-density-and-composition-along-a-climatic-gradient-in-the-temperate-steppe-of-northern-china
#4
Jianqiang Qian, Zhengwen Wang, Jitka Klimešová, Xiaotao Lü, Wennong Kuang, Zhimin Liu, Xingguo Han
Background and Aims: Understanding the changes in below-ground bud bank density and composition along a climatic gradient is essential for the exploration of species distribution pattern and vegetation composition in response to climatic changes. Nevertheless, investigations on bud banks along climatic gradients are still scarce. The below-ground bud bank is expected to be reduced in size in arid conditions, and costly, bud-bearing organs with long spacers would be replaced by more compact forms with buds that are better protected than those found in moist conditions...
June 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28632398/the-mitochondrial-protein-atlas-a-database-of-experimentally-verified-information-on-the-human-mitochondrial-proteome
#5
Noa Godin, Jerry Eichler
Given its central role in various biological systems, as well as its involvement in numerous pathologies, the mitochondrion is one of the best-studied organelles. However, although the mitochondrial genome has been extensively investigated, protein-level information remains partial, and in many cases, hypothetical. The Mitochondrial Protein Atlas (MPA; URL: lifeserv.bgu.ac.il/wb/jeichler/MPA ) is a database that provides a complete, manually curated inventory of only experimentally validated human mitochondrial proteins...
June 20, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28631534/measuring-well-being-in-israel-and-palestine
#6
Guido Veronese, Alessandro Pepe, Jamal Dagdouke, Loredana Addimando, Shaher Yagi
This work presents the psychometric properties of the Subjective Well-Being Assessment Scale in a sample of 423 participants composed of Israeli Arabs and Palestinians from the West Bank/Gaza Strip. Psychometric assessment of the instrument was based on confirmatory factor analysis. The convergent and discriminant validity of Subjective Well-Being Assessment Scale were also tested via administration of the General Health Questionnaire and the Positive and Negative Affect Scale. The results suggest that Subjective Well-Being Assessment Scale is valid, reliable, and solid from a psychometric point of view and provides an accurate assessment of respondents' well-being...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28631162/core-curriculum-case-illustration-blunt-traumatic-thoracic-aortic-pseudo-aneurysm
#7
Muhammad Mubashir Ramzan, Shaimaa Abdelhassib Fadl, Jeffrey D Robinson
Core Curriculum Illustration: [blunt thoracic aortic pseudo aneurysm]. This is the [40th] installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.aseronline.org/curriculum/toc.html...
June 19, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28630153/membrane-spanning-%C3%AE-helical-barrels-as-tractable-protein-design-targets
#8
REVIEW
Ai Niitsu, Jack W Heal, Kerstin Fauland, Andrew R Thomson, Derek N Woolfson
The rational (de novo) design of membrane-spanning proteins lags behind that for water-soluble globular proteins. This is due to gaps in our knowledge of membrane-protein structure, and experimental difficulties in studying such proteins compared to water-soluble counterparts. One limiting factor is the small number of experimentally determined three-dimensional structures for transmembrane proteins. By contrast, many tens of thousands of globular protein structures provide a rich source of 'scaffolds' for protein design, and the means to garner sequence-to-structure relationships to guide the design process...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28628820/river-flow-is-critical-for-vegetation-dynamics-lessons-from-multi-scale-analysis-in-a-hyper-arid-endorheic-basin
#9
Qin Shen, Guangyao Gao, Yihe Lü, Shuai Wang, Xiaohui Jiang, Bojie Fu
Knowledge of the spatio-temporal responses of vegetation dynamics to hydro-climatic factors is important to assess ecological restoration efforts in arid and semiarid areas. In this study, the vegetation dynamics during 2000-2015 were investigated in the downstream area of the Heihe River Basin (HRB) in Northwest China where an ecological water diversion project (EWDP) commenced in 2000. The spatio-temporal relationships between vegetation cover and climatic factors (precipitation and temperature) and available water resources (river flow and groundwater) were determined...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28628630/bird-sound-spectrogram-decomposition-through-non-negative-matrix-factorization-for-the-acoustic-classification-of-bird-species
#10
Jimmy Ludeña-Choez, Raisa Quispe-Soncco, Ascensión Gallardo-Antolín
Feature extraction for Acoustic Bird Species Classification (ABSC) tasks has traditionally been based on parametric representations that were specifically developed for speech signals, such as Mel Frequency Cepstral Coefficients (MFCC). However, the discrimination capabilities of these features for ABSC could be enhanced by accounting for the vocal production mechanisms of birds, and, in particular, the spectro-temporal structure of bird sounds. In this paper, a new front-end for ABSC is proposed that incorporates this specific information through the non-negative decomposition of bird sound spectrograms...
2017: PloS One
https://www.readbyqxmd.com/read/28627860/the-world-health-organization-disability-assessment-schedule-2-0-can-predict-the-institutionalization-of-the-patients-with-stroke
#11
Hsiang-Yueh Hu, Wen-Chou Chi, Kwang-Hwa Chang, Chia-Feng Yen, Reuben Escorpizo, Hua-Fang Liao, Shih-Wei Huang, Tsan-Hon Liou
BACKGROUND: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a well-known questionnaire used to evaluate disability. We can not only evaluate disability but also obtain additional information by using the standardized WHODAS 2.0 scores. AIM: To predict the institutionalization of the patients with stroke by using the standardized WHODAS 2.0 scores. DESIGN: Observational study. SETTING: The data of 10,255 patients with stroke were acquired from the Data Bank of Persons with Disabilities (TDPD) in Taiwan...
June 19, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28626370/donor-safety-in-haemapheresis-development-of-an-internet-based-registry-for-comprehensive-assessment-of-adverse-events-from-healthy-donors
#12
Hans-Gert Heuft, Eike Fischer, Tina Weingand, Thomas Burkhardt, Gerda Leitner, Hagen Baume, Jörg-Peter Schmidt, Andreas Buser, Gabriele Fauchald, Ute Reinicke Voigt, Behrouz Mansouri-Taleghani
BACKGROUND: Currently, there is an extensive but highly inconsistent body of literature regarding donor adverse events (AEs) in haemapheresis. As the reports diverge with respect to types and grading of AEs, apheresis procedures and machines, the range of haemapheresis-related AEs varies widely from about 0.03% to 6.6%. METHODS: The German Society for Transfusion Medicine and Immunohaematology (DGTI) formed a 'Haemapheresis Vigilance Working Party' (Arbeitsgemeinschaft Hämapheresevigilanz; AGHV) to create an on-line registry for comprehensive and comparable AE assessment with all available apheresis devices in all types of preparative haemapheresis: plasmapheresis (PLS), plateletpheresis (PLT), red blood cell apheresis, all kind of leukaphereses (autologous/allogeneic blood stem cell apheresis, granulocyte apheresis, lymphocyte/monocyte apheresis) and all possible types of multi-component apheresis...
June 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28626369/biophysical-and-biochemical-markers-of-red-blood-cell-fragility
#13
Ariel Orbach, Orly Zelig, Saul Yedgar, Gregory Barshtein
BACKGROUND: Red blood cells (RBCs) undergo a natural aging process occurring in the blood circulation throughout the RBC lifespan or during routine cold storage in the blood bank. The aging of RBCs is associated with the elevation of mechanical fragility (MF) or osmotic fragility (OF) of RBCs, which can lead to cell lysis. The present study was undertaken to identify RBC properties that characterize their susceptibility to destruction under osmotic/mechanical stress. METHODS: RBCs were isolated from freshly donated blood or units of packed RBCs (PRBCs) and suspended in albumin-supplemented phosphate-buffered saline (PBS)...
June 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28626038/phenology-of-perennial-native-grass-belowground-axillary-buds-in-the-northern-mixed-grass-prairie
#14
Morgan L Russell, Lance T Vermeire, Amy C Ganguli, John R Hendrickson
PREMISE OF THE STUDY: Vegetative reproduction from belowground bud banks is the primary driver of grassland systems. Despite the importance of bud banks, the timing of recruitment and the crucial link between formation and maintenance is unknown. METHODS: We assessed patterns of belowground bud development, dormancy, and mortality associated with three perennial native grasses in the northern Great Plains. Temperature and soil moisture were measured below the soil surface to determine relationships with belowground bud development...
June 16, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28625210/household-everyday-functioning-in-the-internet-age-online-shopping-and-banking-skills-are-affected-in-hiv-associated-neurocognitive-disorders
#15
Steven Paul Woods, Jennifer E Iudicello, Erin E Morgan, Marizela Verduzco, Tyler V Smith, Clint Cushman
OBJECTIVES: The Internet is a fundamental tool for completing many different instrumental activities of daily living (IADL), including shopping and banking. Persons with HIV-associated Neurocognitive Disorders (HAND) are at heightened risk for IADL problems, but the extent to which HAND interferes with the performance of Internet-based household IADLs is not known. METHODS: Ninety-three individuals with HIV disease, 43 of whom were diagnosed with HAND, and 42 HIV- comparison participants completed Internet-based tests of shopping and banking...
June 19, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28625022/ethical-moral-and-theological-insights-into-advances-in-male-pediatric-and-adolescent-fertility-preservation
#16
REVIEW
J J Ramstein, J Halpern, A J Gadzinski, R E Brannigan, J F Smith
The successful treatment of boys with cancer has led to increasing attention to preserving their quality of life after completing cancer therapy. One of the top priorities for living a full life is keeping open the opportunity to have children. While sperm banking for males facing sterilizing cancer treatment can be effective, this approach requires subsequent use of reproductive procedures such as in vitro fertilization (IVF) or intrauterine insemination (IUI) to achieve a pregnancy. Advances in fertility preservation techniques may allow pre-pubertal boys to conceive using advanced stem cell technologies and stem cell transplantation in the future...
June 18, 2017: Andrology
https://www.readbyqxmd.com/read/28624473/antibody-blood-brain-barrier-efflux-is-modulated-by-glycan-modification
#17
John M Finke, Kari R Ayres, Ryan P Brisbin, Hali A Hill, Emily E Wing, William A Banks
BACKGROUND: Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification alters antibody blood-brain barrier permeability was tested here. METHODS: The blood-brain barrier permeability coefficient Pe of different glycosylated states of anti-amyloid IgG was measured using in vitro models of brain microvascular endothelial cells...
June 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28624388/geo-economic-variations-in-epidemiology-patterns-of-care-and-outcomes-in-patients-with-acute-respiratory-distress-syndrome-insights-from-the-lung-safe-prospective-cohort-study
#18
John G Laffey, Fabiana Madotto, Giacomo Bellani, Tài Pham, Eddy Fan, Laurent Brochard, Pravin Amin, Yaseen Arabi, Ednan K Bajwa, Alejandro Bruhn, Vladimir Cerny, Kevin Clarkson, Leo Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Jose A Lorente, Lia McNamee, Nicolas Nin, Jose Emmanuel Palo, Lise Piquilloud, Haibo Qiu, Juan Ignacio Silesky Jiménez, Andres Esteban, Daniel F McAuley, Frank van Haren, Marco Ranieri, Gordon Rubenfeld, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
BACKGROUND: Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE). METHODS: LUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents...
June 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28623828/pcdd-f-isomers-signature-effect-of-metal-chlorides-and-oxides
#19
Mengmei Zhang, Alfons Buekens, Kees Olie, Xiaodong Li
A recent paper presented the results from de novo tests, involving 11 distinct catalytic systems (oxides and chlorides of Cd, Cr, Cu, Ni, and Zn, as well as a blank sample). Their PCDD and PCDF formation activity was shown. This paper further assesses their isomer signature, with special emphasis on those congeners associated with chlorophenol precursor routes, and on 2,3,7,8- and 1,9-substituted congeners. Each metal catalyst generates a significantly different signature, also affected by the presence or absence of oxygen in the reaction atmosphere...
June 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28623087/highly-multiplex-real-time-pcr-based-screening-for-blood-borne-pathogens-on-an-openarray-platform
#20
Elena Grigorenko, Carolyn Fisher, Sunali Patel, Valerie Winkelman, Phillip Williamson, Caren Chancey, Germán Añez, Maria Rios, Victoria Majam, Sanjai Kumar, Robert Duncan
Molecular diagnostics are increasingly used in the blood bank industry. A device that can combine simultaneous detection of multiple targets with the flexibility of inclusion of emerging pathogens is desirable for testing blood products. A highly multiplexed blood-borne pathogen panel (BBPP) using dual-label probe chemistry (TaqMan assays) was developed for simultaneous detection and discrimination of 17 viral pathogens in human plasma samples and 13 bacterial and protozoan pathogens in human blood samples on the OpenArray platform...
June 12, 2017: Journal of Molecular Diagnostics: JMD
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