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Atherosclerosis MMPs

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https://www.readbyqxmd.com/read/28254386/the-role-of-exercise-training-and-the-endocannabinoid-system-in-atherosclerotic-plaque-burden-and-composition-in-apo-e-deficient-mice
#1
Michalis Katsimpoulas, Nikolaos E Kadoglou, Petros Moustardas, Alkistis Kapelouzou, Eleni Dede, Nikolaos Kostomitsopoulos, Panayotis E Karayannacos, Alkiviadis Kostakis, Christos D Liapis
INTRODUCTION: We investigated the effect of combining exercise training and treatment with an endocannabinoid receptor 1 inhibitor (Rimonabant) on atherosclerosis burden and composition. METHODS: Forty-eight apolipoprotein E-deficient (ApoE-/-) mice were kept on a 16-week high-fat diet. Mice were then placed on a normal diet and were randomized to the following groups with n=12 mice for 6 more weeks: 1) Control (Co) - no intervention; 2) Exercise (Ex) - exercise training on treadmill; 3) Rimonabant (Ri) - oral administration of rimonabant (10 mg/kg/day); or 4) Rimonabant+Exercise (RiEx) - combination of Ri and Ex groups treatment...
November 16, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28205286/association-of-mmp-9-gene-polymorphisms-with-nephrolithiasis-patients
#2
Atheer Awad Mehde, Wesen Adel Mehdi, Faridah Yusof, Raha Ahmed Raus, Zaima Azira Zainal Abidin, Hamid Ghazali, Azlina Abd Rahman
BACKGROUND: Nephrolithiasis is one of the causes which lead to chronic kidney disease (CKD). Matrix metalloproteinases (MMPs) are endopeptidases degrading extracellular matrix which correlate with the pathogenesis of atherosclerosis. The current study was designed to analyze the association of (R279Q, C1562T) polymorphism of MMP-9 with nephrolithiasis patients. METHODS: Genotyping of MMP-9/R279Q and of MMP-9/C1562T polymorphism were carried out by PCR-based restriction digestion method...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28205274/genetic-variants-rs1994016-and-rs3825807-in-adamts7-affect-its-mrna-expression-in-atherosclerotic-occlusive-peripheral-arterial-disease
#3
Burcu Bayoglu, Caner Arslan, Cigdem Tel, Turgut Ulutin, Ahmet Dirican, Serkan Burc Deser, Mujgan Cengiz
AIM: Peripheral artery disease (PAD) is a vascular disease affecting peripheral circulation. Recently, genome-wide association studies revealed a relationship between single nucleotide polymorphisms (SNPs) in ADAMTS7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we aimed to determine ADAMTS7 expression in peripheral blood mononuclear cells (PBMCs) and the frequency of ADAMTS7 rs1994016 and rs3825807 polymorphisms in a sample of Turkish patients with PAD, and to evaluate the association of matrix metalloproteinase (MMP) levels with PAD development...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28155628/matrix-gelatinases-in-atherosclerosis-and-diabetic-nephropathy-progress-and-challenges
#4
Grigorios G Dimas, Triantafyllos P Didangelos, Dimitrios M Grekas
Matrix metalloproteinases (MMPs) are zinc-dependent proteases that degrade components of the extracellular matrix (ECM). In glomerular disease, MMPs are major regulators of ECM degradation as well as structural and functional integrity in the glomerulus. In altered matrix composition diseases, glomerular damage is due to increased degradation of kidney and vessel basement membranes (BMs) by MMPs. MMP -2 and -9 are both considered as the main enzymes that degrade collagen type-IV (coll-IV), which represents the key collagenous component of ECM and constitutes the architectural structure of vessels and glomerular BM...
February 2, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28128285/differentially-expressed-genes-and-canonical-pathway-expression-in-human-atherosclerotic-plaques-tampere-vascular-study
#5
Miska Sulkava, Emma Raitoharju, Mari Levula, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Ari Mennander, Otso Järvinen, Rainer Zeitlin, Juha-Pekka Salenius, Thomas Illig, Norman Klopp, Nina Mononen, Reijo Laaksonen, Mika Kähönen, Niku Oksala, Terho Lehtimäki
Cardiovascular diseases due to atherosclerosis are the leading cause of death globally. We aimed to investigate the potentially altered gene and pathway expression in advanced peripheral atherosclerotic plaques in comparison to healthy control arteries. Gene expression analysis was performed (Illumina HumanHT-12 version 3 Expression BeadChip) for 68 advanced atherosclerotic plaques (15 aortic, 29 carotid and 24 femoral plaques) and 28 controls (left internal thoracic artery (LITA)) from Tampere Vascular Study...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27793533/association-of-matrix-metalloproteinase-1-and-matrix-metalloproteinase-3-gene-variants-with-ischemic-stroke-and-its-subtype
#6
Xiao-Ya Huang, Li-Ya Han, Xiang-Dong Huang, Chao-Hong Guan, Xin-Lei Mao, Zu-Sen Ye
BACKGROUND: Genetic variations in the genes of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of ischemic stroke (IS). Here we investigate the association between MMP-1 -1607 1G/2G and MMP-3 -1171 5A/6A genetic polymorphisms and etiological subtypes of IS in the Han Chinese population. METHODS: A total of 640 eligible patients with IS and 637 age- and gender-matched apparently healthy volunteers were enrolled. Subtypes of IS were classified by Trial of Org 10172 in Acute Stroke Treatment criteria...
October 25, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27696839/novel-potent-proline-based-metalloproteinase-inhibitors-design-radio-synthesis-and-first-in-vivo-evaluation-as-radiotracers-for-positron-emission-tomography
#7
Dmitrii V Kalinin, Stefan Wagner, Burkhard Riemann, Sven Hermann, Frederike Schmidt, Christoph Becker-Pauly, Stefan Rose-John, Michael Schäfers, Ralph Holl
As dysregulation of matrix metalloproteinase (MMP) activity is associated with a wide range of pathophysiological processes like cancer, atherosclerosis, and arthritis, MMPs represent a valuable target for the development of new therapeutics and diagnostic tools. We herein present the chiral pool syntheses, in vitro evaluation, and SAR studies of a series of d- and l-proline- as well as of (4R)-4-hydroxy-l-proline-derived MMP inhibitors possessing general formula 1. Some of the synthesized hydroxamic acids were found to be potent MMP inhibitors with IC50 values in the nanomolar range, also demonstrating no off-target effects toward the other tested Zn(2+)-dependent metalloproteases (ADAMs and meprins)...
October 27, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27694328/novel-role-for-matrix-metalloproteinase-9-in-modulation-of-cholesterol-metabolism
#8
Samuel Hernandez-Anzaldo, Vesna Brglez, Bianca Hemmeryckx, Dickson Leung, Janos G Filep, Jean E Vance, Dennis E Vance, Zamaneh Kassiri, Roger H Lijnen, Gérard Lambeau, Carlos Fernandez-Patron
BACKGROUND: The development of atherosclerosis is strongly linked to disorders of cholesterol metabolism. Matrix metalloproteinases (MMPs) are dysregulated in patients and animal models with atherosclerosis. Whether systemic MMP activity influences cholesterol metabolism is unknown. METHODS AND RESULTS: We examined MMP-9-deficient (Mmp9(-/-)) mice and found them to have abnormal lipid gene transcriptional responses to dietary cholesterol supplementation. As opposed to Mmp9(+/+) (wild-type) mice, Mmp9(-/-) mice failed to decrease the hepatic expression of sterol regulatory element binding protein 2 pathway genes, which control hepatic cholesterol biosynthesis and uptake...
September 30, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27578362/human-paraoxonase-gene-cluster-overexpression-alleviates-angiotensin-ii-induced-cardiac-hypertrophy-in-mice
#9
Jian-Fei Pei, Yun-Fei Yan, Xiaoqiang Tang, Yang Zhang, Shen-Shen Cui, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu
Cardiac hypertrophy is the strongest predictor of the development of heart failure, and anti-hypertrophic treatment holds the key to improving the clinical syndrome and increasing the survival rates for heart failure. The paraoxonase (PON) gene cluster (PC) protects against atherosclerosis and coronary artery diseases. However, the role of PC in the heart is largely unknown. To evaluate the roles of PC in cardiac hypertrophy, transgenic mice carrying the intact human PON1, PON2, and PON3 genes and their flanking sequences were studied...
November 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27363580/inhibition-of-hypoxia-inducible-factor-1%C3%AE-attenuates-abdominal-aortic-aneurysm-progression-through-the-down-regulation-of-matrix-metalloproteinases
#10
Shih-Hung Tsai, Po-Hsun Huang, Yu-Juei Hsu, Yi-Jen Peng, Chien-Hsing Lee, Jen-Chun Wang, Jaw-Wen Chen, Shing-Jong Lin
Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge at human abdominal aortic aneurysm (AAA) tissues. While our initial in vitro experiments had shown that deferoxamine (DFO) could attenuate angiotensin II (AngII) induced endothelial activations; we unexpectedly found that DFO augmented the severity of AngII-induced AAA, at least partly through increased accumulation of HIF-1α...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27362269/reverse-regulatory-pathway-h2s-pge2-mmp-in-human-aortic-aneurysm-and-saphenous-vein-varicosity
#11
Ingrid Gomez, Gulsev Ozen, Catherine Deschildre, Yasmine Amgoud, Lilia Boubaya, Isabelle Gorenne, Chabha Benyahia, Thomas Roger, Guy Lesèche, Erwan Galardon, Gokce Topal, Marie-Paule Jacob, Dan Longrois, Xavier Norel
Hydrogen sulfide (H2S) is a mediator with demonstrated protective effects for the cardiovascular system. On the other hand, prostaglandin (PG)E2 is involved in vascular wall remodeling by regulating matrix metalloproteinase (MMP) activities. We tested the hypothesis that endogenous H2S may modulate PGE2, MMP-1 activity and endogenous tissue inhibitors of MMPs (TIMP-1/-2). This regulatory pathway could be involved in thinning of abdominal aortic aneurysm (AAA) and thickening of saphenous vein (SV) varicosities...
2016: PloS One
https://www.readbyqxmd.com/read/27143852/zoledronate-upregulates-mmp-9-and-13-in-rat-vascular-smooth-muscle-cells-by-inducing-oxidative-stress
#12
Mehmet Zuhuri Arun, Buket Reel, Graciela B Sala-Newby, Mark Bond, Aikaterini Tsaousi, Perry Maskell, Andrew C Newby
BACKGROUND: Bisphosphonates, including zoledronate, target osteoclasts and are widely used in the treatment of osteoporosis and other bone resorption diseases, despite side effects that include damaging the stomach epithelium. Beneficial and adverse effects on other organ systems, including the cardiovascular system, have also been described and could impact on the use of bisphosphonates as therapeutic agents. Vascular smooth muscle cells (VSMCs) are major constituents of the normal vascular wall and have a key role in intimal thickening and atherosclerosis, in part by secreting MMPs that remodel the extracellular matrix and cleave cell surface proteins or secreted mediators...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27042350/matrix-metalloproteinases-and-subclinical-atherosclerosis-in-chronic-kidney-disease-a-systematic-review
#13
REVIEW
Andreas Kousios, Panayiotis Kouis, Andrie G Panayiotou
Background. Cardiovascular disease (CVD) remains a significant problem in Chronic Kidney Disease (CKD). Subclinical atherosclerosis identified by noninvasive methods could improve CVD risk prediction in CKD but these methods are often unavailable. We therefore systematically reviewed whether circulating levels of Matrix Metalloproteinases (MMPs) and tissue inhibitors (TIMPs) are associated with subclinical atherosclerosis in CKD, as this would support their use as biomarkers or pharmacologic targets. Methods...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/26988435/chungtaejeon-a-korean-fermented-tea-prevents-the-risk-of-atherosclerosis-in-rats-fed-a-high-fat-atherogenic-diet
#14
Keshav Raj Paudel, Ung-Won Lee, Dong-Wook Kim
OBJECTIVE: Hypercholesterolemia is one of the well-established risk factors for cardiovascular mortality and morbidity in coronary heart disease. The aim of this study was to investigate the anti-atherogenic effect of Chungtaejeon (CTJ, a Korean fermented tea) aqueous extract on proliferation and migration of human aortic smooth muscle cells (HASMCs) in vivo and in vitro. METHODS: The authors used high-fat atherogenic diet (HFAD) to induce hyperlipidemia in Wistar rats in in vivo animal experiments and used HASMCs for in vitro cell experiments...
March 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/26836482/polyphenols-and-polypeptides-in-chinese-rice-wine-inhibit-homocysteine-induced-proliferation-and-migration-of-vascular-smooth-muscle-cells
#15
Liping Meng, Longbin Liu, Changzuan Zhou, Sunlei Pan, Xiaoya Zhai, Chengjian Jiang, Yan Guo, Zheng Ji, Jufang Chi, Fang Peng, Hangyuan Guo
The beneficial effect of Chinese rice wine on atherosclerosis has been proved, but the exact components that have the cardiovascular protective effect are still unknown. This study aimed to explore the exact ingredients in Chinese rice wine that could inhibit homocysteine (Hcy)-induced vascular smooth muscle cell (VSMC) proliferation and migration. VSMCs were divided into 7 groups: control, Hcy (1 mmol/L), Hcy + oligosaccharide, Hcy + polypeptides, Hcy + polyphenols, Hcy + alcohol, and Hcy + Chinese rice wine...
June 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/26822129/matrix-metalloproteinase-12-modulates-high-fat-diet-induced-glomerular-fibrogenesis-and-inflammation-in-a-mouse-model-of-obesity
#16
Honglin Niu, Ying Li, Haibin Li, Yanqing Chi, Minghui Zhuang, Tao Zhang, Maodong Liu, Lei Nie
Obesity-induced kidney injury contributes to albuminuria, which is characterized by a progressive decline in renal function leading to glomerulosclerosis and renal fibrosis. Matrix metalloproteinases (MMPs) modulate inflammation and fibrosis by degrading a variety of extracellular matrix and regulating the activities of effector proteins. Abnormal regulation of MMP-12 expression has been implicated in abdominal aortic aneurysm, atherosclerosis, and emphysema, but the underlying mechanisms remain unclear. The present study examined the function of MMP-12 in glomerular fibrogenesis and inflammation using apo E(-/-) or apo E(-/-)MMP-12(-/-) mice and maintained on a high-fat-diet (HFD) for 3, 6, or 9 months...
January 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26709763/regulation-and-involvement-of-matrix-metalloproteinases-in-vascular-diseases
#17
REVIEW
Matthew Amin, Sathnur Pushpakumar, Nino Muradashvili, Sourav Kundu, Suresh C Tyagi, Utpal Sen
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose main function is to degrade and deposit structural proteins within the extracellular matrix (ECM). A dysregulation of MMPs is linked to vascular diseases. MMPs are classified into collagenases, gelatinases, membrane-type, metalloelastase, stromelysins, matrilysins, enamelysins, and unclassified subgroups. The production of MMPs is stimulated by factors such as oxidative stress, growth factors and inflammation which lead to its up- or down-regulation with subsequent ECM remodeling...
January 1, 2016: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/26645981/differential-effects-of-tissue-inhibitor-of-metalloproteinase-timp-1-and-timp-2-on-atherosclerosis-and-monocyte-macrophage-invasion
#18
Karina Di Gregoli, Sarah J George, Christopher L Jackson, Andrew C Newby, Jason L Johnson
AIMS: MMPs contribute to atherosclerotic plaque progression and instability, but the relative potency of their endogenous tissue inhibitors of metalloproteinases (TIMPs) as protective factors has not been defined. We therefore investigated the impact of TIMP-1 and TIMP-2 knockout on atherosclerotic plaque burden and composition in apolipoprotein E-knockout (Apoe(-/-)) mice and studied the underlying effects on monocyte/macrophage behaviour. METHODS AND RESULTS: Analysis of brachiocephalic artery plaques revealed comparable atherosclerotic lesion areas between TIMP-1(-/-) Apoe(-/-) or TIMP-2(-/-) Apoe(-/-) double deficient mice and relevant age-matched, strain-matched Apoe(-/-) controls after 8 weeks of high-fat feeding...
February 1, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26339779/stanford-a-acute-aortic-dissection-inflammation-and-metalloproteinases-a-review
#19
REVIEW
Noemi Cifani, Maria Proietta, Luigi Tritapepe, Cira Di Gioia, Livia Ferri, Maurizio Taurino, Flavia Del Porto
Acute aortic dissection (AAD) is a life-threatening disease with an incidence of about 2.6-3.6 cases per 100,000/year. Depending on the site of rupture, AAD is classified as Stanford-A when the ascending aortic thoracic tract and/or the arch are involved, and Stanford-B when the descending thoracic aorta and/or aortic abdominal tract are targeted. It was recently shown that inflammatory pathways underlie aortic rupture in both type A and type B Stanford AAD. An immune infiltrate has been found within the middle and outer tunics of dissected aortic specimens...
2015: Annals of Medicine
https://www.readbyqxmd.com/read/26330106/matrix-metalloproteinase-9-mmp-9-gene-polymorphism-in-stroke-patients
#20
Kinga Buraczynska, Jacek Kurzepa, Andrzej Ksiazek, Monika Buraczynska, Konrad Rejdak
Matrix metalloproteinases (MMPs), endopeptidases degrading extracellular matrix, play an important role in the pathogenesis of atherosclerosis and vascular disease. The aim of this study was to evaluate the association between the C(-1562)T functional polymorphism in the MMP-9 gene and risk of stroke. We examined 322 patients with stroke and 410 controls. In the patient group, 52 % had type 2 diabetes. All subjects were genotyped for the C(-1562)T polymorphism by polymerase chain reaction and restriction analysis...
December 2015: Neuromolecular Medicine
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