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https://www.readbyqxmd.com/read/29911634/blockage-of-lysophosphatidic-acid-reverses-arthritis-induced-hypersensitivity-and-cav%C3%AE-2%C3%AE-1-and-p2x3-expression-in-dorsal-root-ganglia
#1
J Su, A Delaney, R Matteo, B Bartlett, K Kultima, T Hökfelt, C I Svensson
Aims The lysophosphatidic acid (LPA) is an important mediator involved in neuropathic and bone cancer pain models. We are investigating if LPA is involved in arthritis-induced pain in the collagen antibody-induced arthritis (CAIA) mice model. Methods Arthritis was induced in male CBA mice by injection of 1.5 mg collagen type II antibody cocktail. Mechanical and thermal sensitivity and the degree of arthritis were assessed with von Frey filaments, Hargreaves box (heat), acetone test (cold) and visual scoring, respectively...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29859140/involvement-of-lpa-signaling-via-lpa-receptor-2-in-the-promotion-of-malignant-properties-in-osteosarcoma-cells
#2
Kaede Takahashi, Kaori Fukushima, Kosuke Tanaka, Kanako Minami, Kaichi Ishimoto, Shiho Otagaki, Nobuyuki Fukushima, Kanya Honoki, Toshifumi Tsujiuchi
Lysophosphatidic acid (LPA) signaling via G protein-coupled LPA receptors mediates various biological effects in cancer cells. This study aimed to investigate the roles of LPA receptors in the regulation of cellular functions during tumor progression in osteosarcoma cells. Long-term cisplatin (CDDP)-treated MG63-C and MG63-R7-C cells were generated from osteosarcoma MG-63 and highly-migratory MG63-R7 cells, respectively. LPAR2 and LPAR3 expression levels were significantly higher in MG63-C cells than in MG-63 cells, while LPAR1 expression was reduced...
May 30, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29805748/limited-fibrosis-accompanies-triple-negative-breast-cancer-metastasis-in-multiple-model-systems-and-is-not-a-preventive-target
#3
Danielle Brooks, Alexandra Zimmer, Lalage Wakefield, L Tiffany Lyle, Simone Difilippantonio, Fabio C Tucci, Stephane Illiano, Christina M Annunziata, Patricia S Steeg
The lysophosphatidic acid receptor 1 (LPAR1) is mechanistically implicated in both tumor metastasis and tissue fibrosis. Previously, metastasis was increased when fulminant fibrosis was first induced in mice, suggesting a direct connection between these processes. The current report examined the extent of metastasis-induced fibrosis in breast cancer model systems, and tested the metastasis preventive efficacy and fibrosis attenuation of antagonists for LPAR1 and Idiopathic Pulmonary Fibrosis (IPF) in breast and ovarian cancer models...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29800307/profiles-of-adjustment-in-pediatric-cancer-survivors-and-their-prediction-by-earlier-psychosocial-factors
#4
Yuko Okado, Christina Rowley, Sasja A Schepers, Alanna M Long, Sean Phipps
Objective: To examine individual differences in pediatric cancer survivors' psychosocial adjustment and test the psychosocial predictors, assessed 2-3 years earlier, of those differences. Method: Pediatric cancer survivors (n = 209, aged 8-17 years at baseline) and their parents were followed for 4 years. They provided reports of survivors' psychosocial adjustment at 3 years post-baseline, and latent profile analysis (LPA) was used to identify subgroups of survivors who differed on those reports...
May 24, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29777586/platelets-autotaxin-and-lysophosphatidic-acid-signaling-win-win-factors-for-cancer-metastasis
#5
REVIEW
Raphael Leblanc, Audrey Houssin, Olivier Peyruchaud
Platelets play a crucial role in the survival of metastatic cells in the blood circulation. Interaction of tumor cells with platelets leads to the production of plethoric factors among which our review will focus on lysophosphatidic acid (LPA) because platelets are the highest producers of this bioactive lysophospholipid in the organism. LPA promotes platelet aggregation and blocking platelet function leads to inhibition of breast cancer cell metastasis through decreased LPA signaling. Autotaxin (ATX), a lysophospholipase D responsible for basal concentration of LPA in blood, was detected in platelet α-granules...
May 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29724718/the-autotaxin-lysophosphatidic-acid-axis-promotes-lung-carcinogenesis
#6
Christiana Magkrioti, Nikos Oikonomou, Eleanna Kaffe, Marios-Angelos Mouratis, Nikos Xylourgidis, Iliana Barbayianni, Petros Megadoukas, Vaggelis Harokopos, Christos Valavanis, Jerold Chun, Alexandra Kosma, Georgios T Stathopoulos, Evangelos Bouros, Demosthenes Bouros, Konstantinos N Syrigos, Vassilis Aidinis
Pathogenesis and progression of lung cancer (LC) are governed by complex interactions between the environment and host genetic susceptibility, which is further modulated by genetic and epigenetic changes. Autotaxin (ATX, ENPP2) is a secreted glycoprotein that catalyzes the extracellular production of lysophosphatidic acid (LPA), a growth-factor-like phospholipid which is further regulated by phospholipid phosphatases (PLPP). LPA's pleiotropic effects in almost all cell types are mediated through at least six, G-protein coupled LPA receptors (LPAR) that exhibit overlapping specificities, widespread distribution, and differential expression profiles...
May 3, 2018: Cancer Research
https://www.readbyqxmd.com/read/29721771/oxidative-stress-stimulates-invasive-potential-in-rat-c6-and-human-u-87-mg-glioblastoma-cells-via-activation-and-cross-talk-between-pkm2-enpp2-and-ape1-enzymes
#7
Ravi P Cholia, Monisha Dhiman, Raj Kumar, Anil K Mantha
Maintaining genomic integrity is essential for cell survival and viability. Reactive oxygen species (ROS) overproduction results in oxidative stress leading to the genomic instability via generation of small base lesions in DNA and these unrepaired DNA damages lead to various cellular consequences including cancer. Recent data support the concept "oxidative stress is an indispensable participant in fostering proliferation, survival, and migration" in various cancer cell types including glioblastoma cells...
May 2, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29675249/ultrasensitive-and-specific-fluorescence-detection-of-a-cancer-biomarker-via-nanomolar-binding-to-a-guanidinium-modified-calixarene
#8
Zhe Zheng, Wen-Chao Geng, Jie Gao, Yu-Ying Wang, Hongwei Sun, Dong-Sheng Guo
We designed a water-soluble guanidinium-modified calix[5]arene to target lysophosphatidic acid (LPA), an ideal biomarker for early diagnosis of ovarian and other gynecologic cancers, achieving binding on the nanomolar level. An indicator displacement assay, coupled with differential sensing, enabled ultrasensitive and specific detection of LPA. Moreover, we show that using a calibration line, the LPA concentration in untreated serum can be quantified in the biologically relevant low μM range with a detection limit of 1...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29669286/platelets-promote-metastasis-via-binding-tumor-cd97-leading-to-bidirectional-signaling-that-coordinates-transendothelial-migration
#9
Yvona Ward, Ross Lake, Farhoud Faraji, Jamie Sperger, Philip Martin, Cameron Gilliard, Kimberly P Ku, Tamara Rodems, David Niles, Heather Tillman, JuanJuan Yin, Kent Hunter, Adam G Sowalsky, Joshua Lang, Kathleen Kelly
Tumor cells initiate platelet activation leading to the secretion of bioactive molecules, which promote metastasis. Platelet receptors on tumors have not been well-characterized, resulting in a critical gap in knowledge concerning platelet-promoted metastasis. We identify a direct interaction between platelets and tumor CD97 that stimulates rapid bidirectional signaling. CD97, an adhesion G protein-coupled receptor (GPCR), is an overexpressed tumor antigen in several cancer types. Purified CD97 extracellular domain or tumor cell-associated CD97 stimulated platelet activation...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29660795/symptom-and-function-profiles-of-men-with-localized-prostate-cancer
#10
Bryce B Reeve, Xianming Tan, Ronald C Chen, Deborah S Usinger, Laura C Pinheiro
BACKGROUND: Men diagnosed with localized prostate cancer seek information on how treatment options may impact their health-related quality of life (HRQOL). The authors used latent profile analysis (LPA) to group men according to their symptom burden and functional status and to identify patient characteristics associated with each HRQOL profile. METHODS: Patients completed the Patient-Reported Outcomes Measurement Information System and the Expanded Prostate Index Composite measures 3 months after treatment initiation...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29620892/hydroxamic-acids-constitute-a-novel-class-of-autotaxin-inhibitors-that-exhibit-in-vivo-efficacy-in-a-pulmonary-fibrosis-model
#11
Aikaterini Nikolaou, Ioanna Ninou, Maroula G Kokotou, Eleanna Kaffe, Antreas Afantitis, Vassilis Aidinis, George Kokotos
Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are involved in various pathological inflammatory conditions, including fibrosis and cancer, and have attracted great interest as medicinal targets over the past decade. Thus, the development of novel potent ATX inhibitors is of great importance. We have developed a novel class of ATX inhibitors containing the zinc binding functionality of hydroxamic acid. Such novel hydroxamic acids that incorporate a non-natural δ-amino acid residue exhibit high in vitro inhibitory potency over ATX (IC50 values 50-60 nM)...
April 26, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29601360/using-a-patient-centered-approach-to-identify-symptom-clusters-among-adolescents-with-cancer
#12
Wei-Wen Wu, Kuan-Chia Lin, Shu-Yuan Liang, Shiann-Tarng Jou
BACKGROUND: Prior studies identifying symptom clusters used a symptom-centered approach to demonstrate the relationship among symptoms. Latent profile analysis (LPA) is a patient-centered approach that classifies individuals from a heterogeneous population into homogeneous subgroups, helping prioritize interventions to focus on clusters with the most severe symptom burden. OBJECTIVE: The aim of this study was to use LPA to determine the best-fit models and to identify phenotypes of severe symptom distress profiles for adolescents with cancer who are undergoing treatment and in survivorship...
March 30, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29600071/prognostic-significance-of-histologic-classification-and-tumor-disappearance-rate-by-computed-tomography-in-lung-cancer
#13
Dohun Kim, Hong Kwan Kim, Seok-Hyung Kim, Ho Yun Lee, Jong Ho Cho, Yong Soo Choi, Kwhanmien Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim
Background: We investigated the prognostic value of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification and assessed the relationship between pathologic invasiveness and tumor disappearance rate (TDR) in lung adenocarcinoma with ground-glass opacity (GGO). Methods: We reviewed data from 202 consecutive patients operated on between 2000 and 2009 for clinical T1-2N0 lung adenocarcinoma with GGO and reclassified their histologic subtypes according to the IASLC/ATS/ERS classification...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29543710/coming-of-age-for-autotaxin-and-lysophosphatidate-signaling-clinical-applications-for-preventing-detecting-and-targeting-tumor-promoting-inflammation
#14
REVIEW
Matthew G K Benesch, Iain T K MacIntyre, Todd P W McMullen, David N Brindley
A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical target for treating chronic inflammatory conditions, mitigating fibrosis progression, and improving the efficacy of existing cancer chemotherapies and radiotherapy. Nearly half of the literature on this axis has been published during the last five years. In cancer biology, LPA signaling is increasingly being recognized as a central mediator of the progression of chronic inflammation in the establishment of a tumor microenvironment which promotes cancer growth, immune evasion, metastasis, and treatment resistance...
March 15, 2018: Cancers
https://www.readbyqxmd.com/read/29516992/correlation-between-epidermal-growth-factor-receptor-mutation-and-histologic-subtypes-or-characteristics-of-computed-tomography-findings-in-patients-with-resected-pulmonary-adenocarcinoma
#15
Danyun Wang, Ning Yan, Xudong Yang, Yuan Ge, Dedong Xu, Guangyuan Shao, Zhongmin Peng
Objective: To investigate the correlation between epidermal growth factor receptor (EGFR) mutation and the histologic subtypes features or computed tomography (CT) findings in patients with resected pulmonary adenocarcinoma. Materials and Methods: We retrospectively reviewed 153 patients underwent surgical resected pulmonary adenocarcinoma. EGFR mutations were detected using the amplification refractory mutation system. Histologic subtype was classified according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society pulmonary adenocarcinoma classification...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29500188/metabolomics-profiles-of-hepatocellular-carcinoma-in-a-korean-prospective-cohort-the-korean-cancer-prevention-study-ii
#16
Sun Ha Jee, Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Hyungyoon Kim, Keum Ji Jung, Seri Hong, Jong Ho Lee
In the prospective Korean Cancer Prevention Study-II (KCPS-II), we investigated the application of metabolomics to differentiate subjects with incident hepatocellular carcinoma (HCC group) from subjects who remained free of cancer (control group) during a mean follow-up period of 7 years with the aim of identifying valuable metabolic biomarkers for HCC. We used baseline serum samples from 75 subjects with incident HCC and 134 age- and gender-matched cancer-free subjects. Serum metabolic profiles associated with HCC incidence were investigated via metabolomics analysis...
May 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29462674/lysophosphatidic-acid-in-medicinal-herbs-enhances-prostaglandin-e-2-and-protects-against-indomethacin-induced-gastric-cell-damage-in-vivo-and-in-vitro
#17
Sheuli Afroz, Ayano Yagi, Kouki Fujikawa, M Motiur Rahman, Katsuya Morito, Tatsuya Fukuta, Shiro Watanabe, Emi Kiyokage, Kazunori Toida, Taro Shimizu, Tatsuhiro Ishida, Kentaro Kogure, Akira Tokumura, Tamotsu Tanaka
Lysophosphatidic acid (LPA) is a bioactive phospholipid that induces diverse biological responses. Recently, we found that LPA ameliorates NSAIDs-induced gastric ulcer in mice. Here, we quantified LPA in 21 medicinal herbs used for treatment of gastrointestinal (GI) disorders. We found that half of them contained LPA at relatively high levels (40-240 μg/g) compared to soybean seed powder (4.6 μg/g), which we previously identified as an LPA-rich food. The LPA in peony (Paeonia lactiflora) root powder is highly concentrated in the lipid fraction that ameliorates indomethacin-induced gastric ulcer in mice...
March 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29407582/nm23-downregulation-and-lysophosphatidic-acid-receptor-edg2-lpa1-upregulation-during-myeloid-differentiation-of-human-leukemia-cells
#18
Junko Okabe-Kado, Yuki Hagiwara-Watanabe, Nozomi Niitsu, Takashi Kasukabe, Yasuhiko Kaneko
The NM23 gene is overexpressed in many hematological malignancies and its overexpression predicts poor treatment outcomes. NM23 overexpression is thought to suppress myeloid differentiation of leukemia cells, but the molecular mechanism is unknown. In breast cancer cells, the lysophosphatidic acid (LPA) receptor EDG2/lpa1 was downregulated by NM23-H1 overexpression, and this reciprocal expression pattern was associated with suppressed or induced cell motility/metastasis. Here, we examined the relationship between EDG2 and NM23 expression during myeloid differentiation of leukemia cells...
March 2018: Leukemia Research
https://www.readbyqxmd.com/read/29386184/lpa-induces-metabolic-reprogramming-in-ovarian-cancer-via-a-pseudohypoxic-response
#19
Ji Hee Ha, Rangasudhagar Radhakrishnan, Muralidharan Jayaraman, Mingda Yan, Jeremy D Ward, Kar-Ming Fung, Katherine Moxley, Anil K Sood, Ciro Isidoro, Priyabrata Mukherjee, Yong Sang Song, Danny N Dhanasekaran
Although hypoxia has been shown to reprogram cancer cells toward glycolytic shift, the identity of extrinsic stimuli that induce metabolic reprogramming independent of hypoxia, especially in ovarian cancer, is largely unknown. In this study, we use patient-derived ovarian cancer cells and high-grade serous ovarian cancer cell lines to demonstrate that lysophosphatidic acid (LPA), a lipid growth factor and GPCR ligand whose levels are substantially increased in ovarian cancer patients, triggers glycolytic shift in ovarian cancer cells...
April 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29378212/systemic-blockade-of-lpa-1-3-lysophosphatidic-acid-receptors-by-ki16425-modulates-the-effects-of-ethanol-on-the-brain-and-behavior
#20
Laura Sánchez-Marín, David Ladrón de Guevara-Miranda, M Carmen Mañas-Padilla, Francisco Alén, Román D Moreno-Fernández, Caridad Díaz-Navarro, José Pérez-Del Palacio, María García-Fernández, Carmen Pedraza, Francisco J Pavón, Fernando Rodríguez de Fonseca, Luis J Santín, Antonia Serrano, Estela Castilla-Ortega
The systemic administration of lysophosphatidic acid (LPA) LPA1/3 receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA1 receptor-null mice engage in increased ethanol consumption, we evaluated the effects of systemic administration of an LPA1/3 receptor antagonist (intraperitoneal ki16425, 20 mg/kg) on ethanol-related behaviors as well as on brain and plasma correlates. Acute administration of ki16425 reduced motivation for ethanol but not for saccharine in ethanol self-administering Wistar rats...
May 1, 2018: Neuropharmacology
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