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LPA Cancer

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https://www.readbyqxmd.com/read/29660795/symptom-and-function-profiles-of-men-with-localized-prostate-cancer
#1
Bryce B Reeve, Xianming Tan, Ronald C Chen, Deborah S Usinger, Laura C Pinheiro
BACKGROUND: Men diagnosed with localized prostate cancer seek information on how treatment options may impact their health-related quality of life (HRQOL). The authors used latent profile analysis (LPA) to group men according to their symptom burden and functional status and to identify patient characteristics associated with each HRQOL profile. METHODS: Patients completed the Patient-Reported Outcomes Measurement Information System and the Expanded Prostate Index Composite measures 3 months after treatment initiation...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29620892/hydroxamic-acids-constitute-a-novel-class-of-autotaxin-inhibitors-that-exhibit-in-vivo-efficacy-in-a-pulmonary-fibrosis-model
#2
Aikaterini Nikolaou, Ioanna Ninou, Maroula G Kokotou, Eleanna Kaffe, Antreas Afantitis, Vassilis Aidinis, George Kokotos
Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are involved in various pathological inflammatory conditions, including fibrosis and cancer, and have attracted a great interest as medicinal targets over the last decade. Thus, the development of novel potent ATX inhibitors is of great importance. We have developed a novel class of ATX inhibitors containing the zinc binding functionality of hydroxamic acid. Such novel hydroxamic acids, that incorporate a non-natural δ-amino acid residue, exhibit high in vitro inhibitory potency over ATX (IC50 values 50-60 nM)...
April 5, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29601360/using-a-patient-centered-approach-to-identify-symptom-clusters-among-adolescents-with-cancer
#3
Wei-Wen Wu, Kuan-Chia Lin, Shu-Yuan Liang, Shiann-Tarng Jou
BACKGROUND: Prior studies identifying symptom clusters used a symptom-centered approach to demonstrate the relationship among symptoms. Latent profile analysis (LPA) is a patient-centered approach that classifies individuals from a heterogeneous population into homogeneous subgroups, helping prioritize interventions to focus on clusters with the most severe symptom burden. OBJECTIVE: The aim of this study was to use LPA to determine the best-fit models and to identify phenotypes of severe symptom distress profiles for adolescents with cancer who are undergoing treatment and in survivorship...
March 30, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29600071/prognostic-significance-of-histologic-classification-and-tumor-disappearance-rate-by-computed-tomography-in-lung-cancer
#4
Dohun Kim, Hong Kwan Kim, Seok-Hyung Kim, Ho Yun Lee, Jong Ho Cho, Yong Soo Choi, Kwhanmien Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim
Background: We investigated the prognostic value of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification and assessed the relationship between pathologic invasiveness and tumor disappearance rate (TDR) in lung adenocarcinoma with ground-glass opacity (GGO). Methods: We reviewed data from 202 consecutive patients operated on between 2000 and 2009 for clinical T1-2N0 lung adenocarcinoma with GGO and reclassified their histologic subtypes according to the IASLC/ATS/ERS classification...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29543710/coming-of-age-for-autotaxin-and-lysophosphatidate-signaling-clinical-applications-for-preventing-detecting-and-targeting-tumor-promoting-inflammation
#5
REVIEW
Matthew G K Benesch, Iain T K MacIntyre, Todd P W McMullen, David N Brindley
A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical target for treating chronic inflammatory conditions, mitigating fibrosis progression, and improving the efficacy of existing cancer chemotherapies and radiotherapy. Nearly half of the literature on this axis has been published during the last five years. In cancer biology, LPA signaling is increasingly being recognized as a central mediator of the progression of chronic inflammation in the establishment of a tumor microenvironment which promotes cancer growth, immune evasion, metastasis, and treatment resistance...
March 15, 2018: Cancers
https://www.readbyqxmd.com/read/29516992/correlation-between-epidermal-growth-factor-receptor-mutation-and-histologic-subtypes-or-characteristics-of-computed-tomography-findings-in-patients-with-resected-pulmonary-adenocarcinoma
#6
Danyun Wang, Ning Yan, Xudong Yang, Yuan Ge, Dedong Xu, Guangyuan Shao, Zhongmin Peng
Objective: To investigate the correlation between epidermal growth factor receptor (EGFR) mutation and the histologic subtypes features or computed tomography (CT) findings in patients with resected pulmonary adenocarcinoma. Materials and Methods: We retrospectively reviewed 153 patients underwent surgical resected pulmonary adenocarcinoma. EGFR mutations were detected using the amplification refractory mutation system. Histologic subtype was classified according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society pulmonary adenocarcinoma classification...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29500188/metabolomics-profiles-of-hepatocellular-carcinoma-in-a-korean-prospective-cohort-the-korean-cancer-prevention-study-ii
#7
Sun Ha Jee, Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Hyungyoon Kim, Keum Ji Jung, Seri Hong, Jong Ho Lee
In the prospective Korean Cancer Prevention Study-II (KCPS-II), we investigated the application of metabolomics to differentiate subjects with incident hepatocellular carcinoma (HCC group) from subjects who remained free of cancer (control group) during a mean follow-up period of 7 years with the aim of identifying valuable metabolic biomarkers for HCC. We used baseline serum samples from 75 subjects with incident HCC and 134 age- and gender-matched cancer-free subjects. Serum metabolic profiles associated with HCC incidence were investigated via metabolomics analysis...
March 2, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29462674/lysophosphatidic-acid-in-medicinal-herbs-enhances-prostaglandin-e-2-and-protects-against-indomethacin-induced-gastric-cell-damage-in-vivo-and-in-vitro
#8
Sheuli Afroz, Ayano Yagi, Kouki Fujikawa, M Motiur Rahman, Katsuya Morito, Tatsuya Fukuta, Shiro Watanabe, Emi Kiyokage, Kazunori Toida, Taro Shimizu, Tatsuhiro Ishida, Kentaro Kogure, Akira Tokumura, Tamotsu Tanaka
Lysophosphatidic acid (LPA) is a bioactive phospholipid that induces diverse biological responses. Recently, we found that LPA ameliorates NSAIDs-induced gastric ulcer in mice. Here, we quantified LPA in 21 medicinal herbs used for treatment of gastrointestinal (GI) disorders. We found that half of them contained LPA at relatively high levels (40-240 μg/g) compared to soybean seed powder (4.6 μg/g), which we previously identified as an LPA-rich food. The LPA in peony (Paeonia lactiflora) root powder is highly concentrated in the lipid fraction that ameliorates indomethacin-induced gastric ulcer in mice...
March 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29407582/nm23-downregulation-and-lysophosphatidic-acid-receptor-edg2-lpa1-upregulation-during-myeloid-differentiation-of-human-leukemia-cells
#9
Junko Okabe-Kado, Yuki Hagiwara-Watanabe, Nozomi Niitsu, Takashi Kasukabe, Yasuhiko Kaneko
The NM23 gene is overexpressed in many hematological malignancies and its overexpression predicts poor treatment outcomes. NM23 overexpression is thought to suppress myeloid differentiation of leukemia cells, but the molecular mechanism is unknown. In breast cancer cells, the lysophosphatidic acid (LPA) receptor EDG2/lpa1 was downregulated by NM23-H1 overexpression, and this reciprocal expression pattern was associated with suppressed or induced cell motility/metastasis. Here, we examined the relationship between EDG2 and NM23 expression during myeloid differentiation of leukemia cells...
January 3, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29386184/lysophosphatidic-acid-induces-metabolic-reprogramming-in-ovarian-cancer-via-a-pseudohypoxic-response
#10
Ji Hee Ha, Rangasudhagar Radhakrishnan, Muralidharan Jayaraman, Mingda Yan, Jeremy D Ward, Kar-Ming Fung, Katherine M Moxley, Anil K Sood, Ciro Isidoro, Priyabrata Mukherjee, Yong Sang Song, Danny N Dhanasekaran
Although hypoxia has been shown to reprogram cancer cells toward glycolytic shift, the identity of extrinsic stimuli that induce metabolic reprogramming independent of hypoxia, especially in ovarian cancer, is largely unknown. In this study, we use patient-derived ovarian cancer cells and high-grade serous ovarian cancer cell lines to demonstrate that lysophosphatidic acid (LPA), a lipid growth factor and GPCR ligand whose levels are substantially increased in ovarian cancer patients, triggers glycolytic shift in ovarian cancer cells...
January 31, 2018: Cancer Research
https://www.readbyqxmd.com/read/29378212/systemic-blockade-of-lpa-1-3-lysophosphatidic-acid-receptors-by-ki16425-modulates-the-effects-of-ethanol-on-the-brain-and-behavior
#11
Laura Sánchez-Marín, David Ladrón de Guevara-Miranda, M Carmen Mañas-Padilla, Francisco Alén, Román D Moreno-Fernández, Caridad Díaz-Navarro, José Pérez-Del Palacio, María García-Fernández, Carmen Pedraza, Francisco J Pavón, Fernando Rodríguez de Fonseca, Luis J Santín, Antonia Serrano, Estela Castilla-Ortega
The systemic administration of lysophosphatidic acid (LPA) LPA1/3 receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA1 receptor-null mice engage in increased ethanol consumption, we evaluated the effects of systemic administration of an LPA1/3 receptor antagonist (intraperitoneal ki16425, 20 mg/kg) on ethanol-related behaviors as well as on brain and plasma correlates. Acute administration of ki16425 reduced motivation for ethanol but not for saccharine in ethanol self-administering Wistar rats...
May 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29369010/effects-of-lpa1-and-lpa6-on-the-regulation-of-colony-formation-activity-in-colon-cancer-cells-treated-with-anticancer-drugs
#12
Kaede Takahashi, Kaori Fukushima, Shiho Otagaki, Kaichi Ishimoto, Kanako Minami, Nobuyuki Fukushima, Kanya Honoki, Toshifumi Tsujiuchi
Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits a variety of cellular responses via the activation of G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). The aim of our study was to investigate effects of LPA receptors on soft agar colony formation in colon cancer cells treated with anticancer drugs. DLD1 cells were treated with fluorouracil (5-FU) or cisplatin (CDDP) for at least six months (DLD-5FU and DLD-CDDP cells, respectively). LPAR1 gene expression was markedly elevated in DLD-5FU cells...
February 2018: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29337044/lysophosphatidic-acid-regulates-the-motility-of-mcf10ca1a-breast-cancer-cell-sheets-via-two-opposing-signaling-pathways
#13
Christina H Stuelten, Rachel M Lee, Wolfgang Losert, Carole A Parent
Aberrant cell migration leads to the dispersal of malignant cells. The ubiquitous lipid mediator lysophosphatidic acid (LPA) modulates cell migration and is implicated in tumor progression. Yet, the signaling cascades that regulate LPA's effect on cell motility remain unclear. Using time-lapse imaging and quantitative analyses, we studied the role of signaling cascades that act downstream of LPA on the motility of MCF10CA1a breast cancer cells. We found that LPA alters cell motility via two major signaling pathways...
May 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29331665/blocking-lpa-dependent-signaling-increases-ovarian-cancer-cell-death-in-response-to-chemotherapy
#14
LeAnn C Rogers, Ryan R Davis, Naveen Said, Thomas Hollis, Larry W Daniel
The paradoxical role of reactive oxygen species in cell death versus cell survival establishes a delicate balance between chemotherapy efficacy and management of detrimental side effects. Normal proliferative signaling requires that cells remain inside a redox range that allows reversible protein oxidation to occur. Shifting the redox environment toward highly reducing or oxidizing states leads to cellular stress and cell death. Reactive oxygen species produced in response to Taxol and cisplatin treatment are necessary for effective cancer cell killing but the same ROS leads to damaging side effects in normal tissues...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29329782/lpa-induced-migration-of-ovarian-cancer-cells-requires-activation-of-erm-proteins-via-lpa-1-and-lpa-2
#15
Jeongrak Park, Jin-Hyeok Jang, Seojin Oh, Minhye Kim, Changhoon Shin, Minseok Jeong, Kyun Heo, Jong Bae Park, Sang Ryong Kim, Yong-Seok Oh
Lysophosphatidic acid (LPA) has been implicated in the pathology of human ovarian cancer. This phospholipid elicits a wide range of cancer cell responses, such as proliferation, trans-differentiation, migration, and invasion, via various G-protein-coupled LPA receptors (LPARs). Here, we explored the cellular signaling pathway via which LPA induces migration of ovarian cancer cells. LPA induced robust phosphorylation of ezrin/radixin/moesin (ERM) proteins, which are membrane-cytoskeleton linkers, in the ovarian cancer cell line OVCAR-3...
April 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29328374/atx%C3%A2-lpa-axis-facilitates-estrogen%C3%A2-induced-endometrial-cancer-cell-proliferation-via-mapk-erk-signaling-pathway
#16
Guo Zhang, Yuan Cheng, Qi Zhang, Xiaoping Li, Jingwei Zhou, Jianliu Wang, Lihui Wei
Autotaxin (ATX) is a key enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). ATX is a crucial factor that facilitates cancer progression; however, the effect of ATX on endometrial cancer has not been explored. The aim of the present study was to investigate the role of ATX in the progression of endometrial cancer. The immunohistochemical results revealed higher protein expression levels of ATX and LPA receptors (LPA 1, 2 and 3) in human endometrial cancer tissue than in non‑carcinoma tissue...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29321663/lpa-signaling-is-regulated-through-the-primary-cilium-a-novel-target-in-glioblastoma
#17
Yuriy V Loskutov, Caryn L Griffin, Kristina M Marinak, Andrey Bobko, Naira V Margaryan, Werner J Geldenhuys, Jann N Sarkaria, Elena N Pugacheva
The primary cilium is a ubiquitous organelle presented on most human cells. It is a crucial signaling hub for multiple pathways including growth factor and G-protein coupled receptors. Loss of primary cilia, observed in various cancers, has been shown to affect cell proliferation. Primary cilia formation is drastically decreased in glioblastoma (GBM), however, the role of cilia in normal astrocyte or glioblastoma proliferation has not been explored. Here, we report that loss of primary cilia in human astrocytes stimulates growth rate in a lysophosphatidic acid (LPA)-dependent manner...
March 2018: Oncogene
https://www.readbyqxmd.com/read/29291160/a-dual-biomarker-detection-platform-for-quantitating-circulating-tumor-dna-ctdna
#18
Chunyan Cai, Zhenzhong Guo, Yiping Cao, Weiying Zhang, Yong Chen
Circulating tumor DNA (ctDNA), which includes DNA mutations, epigenetic alterations and other forms of tumor-specific abnormalities, is a promising "real-time" biomarker for noninvasive cancer assessment. Tumor DNA is of great value in the process of cancer treatment, including diagnostic and prognostic information before, during treatment and at progression. Here we introduce a peptide nucleic acids probe-gold nanoparticles (PNA-AuNPs) and lead phosphate apoferritin (LPA)-based dual biomarker detection platform, which could be used in a DNA biosensor to quantify ctDNA by detection of tumor-specific mutations and methylation of PIK3CA gene...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29258184/lysophospholipid-related-diseases-and-ppar%C3%AE-signaling-pathway
#19
REVIEW
Tamotsu Tsukahara, Yoshikazu Matsuda, Hisao Haniu
The nuclear receptor superfamily includes ligand-inducible transcription factors that play diverse roles in cell metabolism and are associated with pathologies such as cardiovascular diseases. Lysophosphatidic acid (LPA) belongs to a family of lipid mediators. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and an intracellular nuclear hormone receptor. In addition, several enzymes that utilize LPA as a substrate or generate it as a product are under its regulatory control...
December 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29198709/cholesterol-inhibits-entotic-cell-in-cell-formation-and-actomyosin-contraction
#20
Banzhan Ruan, Bo Zhang, Ang Chen, Long Yuan, Jianqing Liang, Manna Wang, Zhengrong Zhang, Jie Fan, Xiaochen Yu, Xin Zhang, Zubiao Niu, You Zheng, Songzhi Gu, Xiaoqing Liu, Hongli Du, Jufang Wang, Xianwen Hu, Lihua Gao, Zhaolie Chen, Hongyan Huang, Xiaoning Wang, Qiang Sun
Cell-in-cell structure is prevalent in human cancer, and associated with several specific pathophysiological phenomena. Although cell membrane adhesion molecules were found critical for cell-in-cell formation, the roles of other membrane components, such as lipids, remain to be explored. In this study, we attempted to investigate the effects of cholesterol and phospholipids on the formation of cell-in-cell structures by utilizing liposome as a vector. We found that Lipofectamine-2000, the reagent commonly used for routine transfection, could significantly reduce entotic cell-in-cell formation in a cell-specific manner, which is correlated with suppressed actomyosin contraction as indicated by reduced β-actin expression and myosin light chain phosphorylation...
January 1, 2018: Biochemical and Biophysical Research Communications
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