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https://www.readbyqxmd.com/read/27911007/assessment-of-subclinical-atherosclerosis-in-hidradenitis-suppurativa
#1
José C Pascual, Iris González, Diego Corona, Patricia Hispán, José M Ramos, José Sánchez-Paya, Gregor B Jemec
BACKGROUND: Patients with Hidradenitis Suppurativa (HS) have an increased prevalence of traditional cardiovascular (CV) risk factors. OBJECTIVE: Our aim was to investigate the association between subclinical atherosclerosis, detected by carotid ultrasound, and HS. METHODS: A prospective observation and analytical study assessing subclinical atherosclerosis using carotid ultrasound in patients with HS. RESULTS: A total of 62 HS-patients and 62 matched-controls were studied...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27903567/increased-plasma-ige-accelerate-atherosclerosis-in-secreted-igm-deficiency
#2
Dimitrios Tsiantoulas, Ilze Bot, Maria Ozsvar Kozma, Laura Goederle, Thomas Perkmann, Karsten Hartvigsen, Daniel H Conrad, Johan Kuiper, Ziad Mallat, Christoph J Binder
RATIONALE: Deficiency of secreted IgM (sIgM(-/-)) accelerates atherosclerosis in Ldlr(-/-) mice. Several atheroprotective effects of increased levels of IgM antibodies have been suggested, including preventing inflammation induced by oxidized LDL and promoting apoptotic cell clearance. However, the mechanisms by which the lack of sIgM promotes lesion formation remain unknown. OBJECTIVE: To identify the mechanisms by which sIgM deficiency accelerates atherosclerosis in mice...
November 30, 2016: Circulation Research
https://www.readbyqxmd.com/read/27885378/netosis-provides-the-link-between-activation-of-neutrophils-on-hemodialysis-membrane-and-comorbidities-in-dialyzed-patients
#3
REVIEW
Marie Korabecna, Vladimir Tesar
INTRODUCTION: Neutrophil extracellular traps (NETs) are formed by activated neutrophils during the process of NETosis in which the nuclear material is released into extracellular space, including DNA molecules, citrullinated histones, and neutrophil granule enzymes, such as elastase. This material forms networks that are able not only to physically entrap bacteria but also to provide elevated concentration of bactericidal components. Over the last years, it has become clear that NETs can also be formed under numerous sterile inflammatory conditions, i...
November 24, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27883026/inhibition-of-lysophosphatidic-acid-receptors-1-and-3-attenuates-atherosclerosis-development-in-ldl-receptor-deficient-mice
#4
Eva Kritikou, Gijs H M van Puijvelde, Thomas van der Heijden, Peter J van Santbrink, Maarten Swart, Frank H Schaftenaar, Mara J Kröner, Johan Kuiper, Ilze Bot
Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as a potent activator for various types of immune cells through its specific membrane receptors LPA1/3. LPA elicits chemotactic, pro-inflammatory and apoptotic effects that lead to atherosclerotic plaque progression. In this study we aimed to inhibit LPA signaling by means of LPA1/3 antagonism using the small molecule Ki16425...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27790832/platelet-activating-factor-paf-a-potential-biomarker-in-acute-coronary-syndrome
#5
P R Anand Vijaya Kumar, Treesa P Varghese, Sreedevi Vanapalli, N K Nair, Menge Denis Mingate
Platelet Activating Factor (PAF) is a potent pro-inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells and initiation and progression of atherosclerosis. The purpose of this article is to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress and platelet reactivity...
October 28, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27785012/docosahexaenoic-acid-liposomes-for-targeting-chronic-inflammatory-diseases-and-cancer-an-in-vitro-assessment
#6
Amr Alaarg, Nan Yeun Jordan, Johan Jf Verhoef, Josbert M Metselaar, Gert Storm, Robbert J Kok
Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis and cancer. ω3 polyunsaturated fatty acids (PUFAs; also known as omega3 fatty acids or fish oil) have beneficial effects against inflammation upon dietary consumption. However, these effects cannot be fully exploited unless diets are enriched with high concentrations of fish oil supplements over long periods of time. Here, a nanomedicine-based approach is presented for delivering effective levels of PUFAs to inflammatory cells...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27769639/platelets-and-infection
#7
Carsten Deppermann, Paul Kubes
The primary function of platelets is to patrol the vasculature and seal vessel breaches to limit blood loss. However, it is becoming increasingly clear that they also contribute to pathophysiological conditions like thrombosis, atherosclerosis, stroke and infection. Severe sepsis is a devastating disease that claims hundreds of thousands of lives every year in North America and is a major burden to the public health system. Platelet surface receptors like GPIb, αIIbβ3, TLR2 and TLR4 are involved in direct platelet-bacteria interactions...
October 18, 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27708207/role-of-oncogene-24p3-neutrophil-gelatinase-associated-lipocalin-ngal-in-digestive-system-cancers
#8
Łukasz Michalak, Magdalena Bulska, Katarzyna Kudłacz, Piotr Szcześniak
Neutrophil gelatinase-associated lipocalin, known also as 24p3 lipocalin, lipocalin-2 or uterocalin (in mouse), is a small secretory protein binding small molecular weight ligands which takes part in numerous processes including apoptosis induction in leukocytes, iron transport, smell, and prostaglandins and retinol transport [19]. It was discovered in activated neutrophils as a covalent peptide associated with human gelatinase neutrophils [7]. Neutrophil lipocalin is secreted physiologically in the digestive system, respiratory tract, renal tubular cells, liver or immunity system...
January 4, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27680774/plasma-cystatin-c-and-neutrophil-gelatinase-associated-lipocalin-in-relation-to-coronary-atherosclerosis-on-intravascular-ultrasound-and-cardiovascular-outcome-impact-of-kidney-function-atheroremo-ivus-study
#9
Milos Brankovic, K Martijn Akkerhuis, Nermina Buljubasic, Jin M Cheng, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Evelyn Regar, Patrick W Serruys, Robert-Jan van Geuns, Eric Boersma, Isabella Kardys
BACKGROUND AND AIMS: We investigated whether plasma cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) are associated with intravascular ultrasound (IVUS)-derived characteristics of coronary atherosclerosis and 1-year adverse coronary events in patients with normal and mildly-to-moderately impaired kidney function. METHODS: Between 2008 and 2011, virtual histology (VH)-IVUS of a non-culprit coronary artery was performed in 581 patients undergoing coronary angiography...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27679792/-the-net-outcome-are-neutrophil-extracellular-traps-of-any-relevance-to-the-pathophysiology-of-autoimmune-disorders-in-childhood
#10
REVIEW
Stavros Giaglis, Sinuhe Hahn, Paul Hasler
Neutrophil extracellular trap (NET) formation represents a form of cell death distinct from apoptosis or necrosis, by which invading pathogens are simultaneously entangled and potentially eliminated. Increased NET formation is observed in systemic lupus erythematosus (SLE), rheumatoid arthritis, antineutrophil cytoplasmic antibody-associated small vessel vasculitis, antiphospholipid antibody syndrome (APS), and psoriasis. NETs contribute to the pathogenesis of autoimmunity by exposing cryptic autoepitopes, which may facilitate the generation of autoantibodies, induce the production of interferons, and activate the complement cascade...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27633389/mkey-a-peptide-inhibitor-of-cxcl4-ccl5-heterodimer-formation-protects-against-stroke-in-mice
#11
Yifang Fan, Xiaoxing Xiong, Yongming Zhang, Dongmei Yan, Zhihong Jian, Baohui Xu, Heng Zhao
BACKGROUND: MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not been studied. We therefore studied the role of MKEY in stroke-induced brain injury in mice. METHODS AND RESULTS: MKEY was injected into mice after stroke with 60 minutes of middle cerebral artery occlusion...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27610311/relation-between-unconjugated-bilirubin-and-rdw-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-in-gilbert-s-syndrome
#12
Hakan Sarlak, Erol Arslan, Mustafa Cakar, Mustafa Tanriseven, Salim Ozenc, Muharrem Akhan, Fatih Bulucu
BACKGROUND: Unconjugated bilirubin (UCB) plays a protective role in coronary artery disease. Red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are inflammatory biomarkers and higher levels are related to atherosclerosis and adverse cardiovascular events. AIM: We aimed to investigate the relation between UCB levels and RDW, NLR, PLR in people with Gilbert's syndrome (GS). MATERIALS AND METHODS: We selected 2166 subjects (1082 with GS and 1084 healthy controls) from a database having 33,695 people...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27609552/epicardial-fat-tissue-thickness-is-increased-in-patients-with-lichen-planus-and-is-linked-to-inflammation-and-dyslipidemia
#13
Ahmet Goktug Ertem, Mehmet Erdogan, Cemal Koseoglu, Gulsen Akoglu, Elcin Ozdemir, Gamze Koseoglu, Serkan Sivri, Telat Keles, Tahir Durmaz, Akın Aktas, Engin Bozkurt
BACKGROUND AND OBJECTIVES: Lichen planus (LP) is a mucocutaneous inflammatory disease. Inflammation plays a major role in the progression of atherosclerosis. Epicardial fat tissue (EFT) has been shown to produce and secrete various proatherogenic and proinflammatory hormones and cytokines. The aim of this study was to assess EFT in patients with lichen planus. METHODS: Fifty-four patients with LP and 50 controls were enrolled in the study. LP was diagnosed according to the World Health Organization criteria...
October 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27586429/nestin-cells-direct-inflammatory-cell-migration-in-atherosclerosis
#14
Raquel Del Toro, Raphael Chèvre, Cristina Rodríguez, Antonio Ordóñez, José Martínez-González, Vicente Andrés, Simón Méndez-Ferrer
Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation...
2016: Nature Communications
https://www.readbyqxmd.com/read/27571356/inflammation-and-vascular-effects-after-repeated-intratracheal-instillations-of-carbon-black-and-lipopolysaccharide
#15
Daniel Vest Christophersen, Nicklas Raun Jacobsen, Ditte Marie Jensen, Ali Kermanizadeh, Majid Sheykhzade, Steffen Loft, Ulla Vogel, Håkan Wallin, Peter Møller
Inflammation and oxidative stress are considered the main drivers of vasomotor dysfunction and progression of atherosclerosis after inhalation of particulate matter. In addition, new studies have shown that particle exposure can induce the level of bioactive mediators in serum, driving vascular- and systemic toxicity. We aimed to investigate if pulmonary inflammation would accelerate nanoparticle-induced atherosclerotic plaque progression in Apolipoprotein E knockout (ApoE-/-) mice. ApoE -/- mice were exposed to vehicle, 8...
2016: PloS One
https://www.readbyqxmd.com/read/27508669/-op-3d-03-association-between-neutrophil-to-lymphocyte-ratio-and-arterial-stiffness-in-a-population-sample
#16
E Huguet, G Maccallini, P Pardini, S Obregon, M Hidalgo, M Haehnel, P Carrizo, M Koretzky, A Di Leva, F Inserra, F Botto, A Scuteri, P M Nilsson, C Kotliar
OBJECTIVE: Immuno-inflammation plays a key role in the process of atherosclerosis and vascular stiffness as surrogates for Early Vascular Ageing (EVA). Our aim was to evaluate the association between the Neutrophil to Lymphocyte Ratio (NLR), a validated inflammatory marker, and arterial stiffness represented by the pulse wave velocity (PWV), in a population-based sample. DESIGN AND METHOD: We included prospectively 237 adults who attended for cardiovascular screening tests...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27502756/-atherothrombosis-associated-micrornas-in-antiphospholipid-syndrome-and-systemic-lupus-erythematosus-patients
#17
C Pérez-Sánchez, M A Aguirre, P Ruiz-Limón, N Barbarroja, Y Jiménez-Gómez, I Arias de la Rosa, A Rodriguez-Ariza, E Collantes-Estévez, P Segui, F Velasco, M J Cuadrado, R Teruel, R González-Conejero, C Martínez, Ch López-Pedrera
MicroRNAs markedly affect the immune system, and have a relevant role in CVD and autoimmune diseases. Yet, no study has analyzed their involvement in atherothrombosis related to APS and SLE patients. This study intended to: 1) identify and characterize microRNAs linked to CVD in APS and SLE; 2) assess the effects of specific autoantibodies. Six microRNAs, involved in atherothrombosis development, were quantified in purified leukocytes from 23 APS and 64 SLE patients, and 56 healthy donors. Levels of microRNAs in neutrophils were lower in APS and SLE than in healthy donors...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27472870/investigation-of-the-correlation-between-some-immune-system-and-biochemical-indicators-in-patients-with-type-2-diabetes
#18
Mohammad Mahdi Eftekharian, Jamshid Karimi, Mojgansadat Safe, Ahmad Sadeghian, Shiva Borzooei, Ehsan Siahpoushi
AIMS/INTRODUCTION: Since changes in some immune system indicators such as leukocyte count and neutrophil to lymphocyte ratio in the blood and Inflammation is directly in relation with the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis, measuring these indicators in patients with type 2 diabetes and comparing them with control group can be a suitable indicator of Inflammation and prognosis of the disease. MATERIALS AND METHODS: The current study was done on 75 patients with type 2 diabetes and 72 healthy individuals as patient and healthy group respectively...
June 8, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27472345/marine-natural-product-inhibitors-of-neutrophil-associated-inflammation
#19
REVIEW
Chun-Yu Chen, Yung-Fong Tsai, Wen-Yi Chang, Shun-Chin Yang, Tsong-Long Hwang
Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated diseases such as chronic obstructive pulmonary disease, atherosclerosis, and hepatitis. Marine organisms are a valuable source of bioactive compounds with potential for industrial and pharmaceutical application...
2016: Marine Drugs
https://www.readbyqxmd.com/read/27465665/treatment-with-the-gpr55-antagonist-cid16020046-increases-neutrophil-activation-in-mouse-atherogenesis
#20
Fabrizio Montecucco, Alexander I Bondarenko, Sébastien Lenglet, Fabienne Burger, Fabiana Piscitelli, Federico Carbone, Aline Roth, Luca Liberale, Franco Dallegri, Karim J Brandt, Rodrigo A Fraga-Silva, Nikolaos Stergiopulos, Vincenzo Di Marzo, François Mach
Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antagonism with CID16020046 would impact on atherosclerotic size and inflammation in two mouse models of early and more advanced atherogenesis. Eleven-week old ApoE-/- mice were fed either a normal diet ([ND] for 16 weeks) or a high-cholesterol diet ([HD] for 11 weeks), resulting in different degrees of hypercholesterolaemia and size of atherosclerosis...
July 28, 2016: Thrombosis and Haemostasis
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