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Shu-Fen Peng, Hung-Kun Hsu, Chun-Cheng Lin, Ya-Ming Cheng, Kuang-Hsing Hsu
The efficient delivery of sufficient amounts of nucleic acids into target cells is critical for successful gene therapy and gene knockdown. The DNA/siRNA co-delivery system has been considered a promising approach for cancer therapy to simultaneously express and inhibit tumor suppressor genes and overexpressed oncogenes, respectively, triggering synergistic anti-cancer effects. Polyethylenimine (PEI) has been identified as an efficient non-viral vector for transgene expression. In this study, we created a very high efficient DNA/siRNA co-delivery system by incorporating a negatively-charged poly-γ-glutamic acid (γ-PGA) into PEI/nucleic acid complexes...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
I M Mykheĭtseva
We explored the melatonin influence on the level of amino acid neurotransmitters of the retina in glaucoma neuropathy in rats. Glaucoma was caused by the prolong systemic introduction of adrenalin. In the study 3 groups were participated: control animals; the model of glaucoma; the model of glaucoma treated with melatonin (M) in the dose 0.1 mg/kg during 1 month. In a vitreous body, as place of retina neuromediator accumulation, free amino acids (AA) were determined with the method of ion-exchange chromatography...
2013: Fiziolohichnyĭ Zhurnal
Vishwajeet Mehandia, Kamala Jyotsna Gutam, Prabhu R Nott
We present measurements of the stress as a function of vertical position in a column of granular material sheared in a cylindrical Couette device. All three components of the stress tensor on the outer cylinder were measured as a function of distance from the free surface at shear rates low enough that the material was in the dense, slow flow regime. We find that the stress profile differs fundamentally from that of fluids, from the predictions of plasticity theories, and from intuitive expectation. We argue that the anomalous stress profile is due to an anisotropic fabric caused by the combined action of gravity and shear...
September 21, 2012: Physical Review Letters
No abstract text is available yet for this article.
1946: Federation Proceedings
U Wüllner, A Kupsch, G Arnold, P Renner, C Scheid, R Scheid, W Oertel, T Klockgether
Experiments in MPTP-treated non-human primates testing potential antiparkinsonian action have shown both, beneficial and adverse effects of gutamate receptor antagonists. To investigate this matter further, the novel competitive NMDA antagonist CGP40.116 was administered systemically to three adult MPTP-treated marmosets. When coadministered subcutaneously with a subthreshold dose of L-DOPA, 2 mg/kg, CGP40.116 25-250 micrograms/kg, increased locomotor activity. However, when administered alone, CGP40.116 had no effect on locomotor activity...
July 1992: Neuropharmacology
J Dudel
Synaptic currents were measured in voltage clamped crayfish muscle fibers which were triggered either by stimulation of the motor axon (EPSC), or by L-gutamate (gEPSC) applied by microiontophoresis or superfusion. Among a number of analogues of glutamate, L-glutamic-acid-gamma-methyl ester, L-glutamic-acid-dimethyl ester and L-aspartate, were reasonably specific antagonists at the motor synapses, although at relatively high concentrations. Aslo, 2-amino-4-phosphono-butyric acid and morphine were effective antagonists; the action of morphine, however, seemed to be unspecific...
May 6, 1977: Pflügers Archiv: European Journal of Physiology
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