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https://www.readbyqxmd.com/read/28917806/portable-and-low-cost-colorimetric-office-paper-based-device-for-phenacetin-detection-in-seized-cocaine-samples
#1
Gabriela O da Silva, William R de Araujo, Thiago R L C Paixão
An office paper-based colorimetric device is proposed as a portable, rapid, and low-cost sensor for forensic applications aiming to detect phenacetin used as adulterant in illicit seized materials such as cocaine. The proposed method uses white office paper as the substrate and wax printing technology to fabricate the detection zones. Based on the optimum conditions, a linear analytical curve was obtained for phenacetin concentrations ranging from 0 to 64.52µgmL(‒1), and the straight line was in accordance with the following equation: (Magenta percentage color) = 1...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917762/full-validation-of-a-method-for-the-determination-of-drugs-of-abuse-in-non-mineralized-dental-biofilm-using-liquid-chromatography-tandem-mass-spectrometry-and-application-to-postmortem-samples
#2
Kerstin Henkel, Markus J Altenburger, Volker Auwärter, Merja A Neukamm
Alternative matrices play a major role in postmortem forensic toxicology, especially if common matrices (like body fluids or hair) are not available. Incorporation of illicit and medicinal drugs into non-mineralized dental biofilm (plaque) seems likely but has not been investigated so far. Analysis of plaque could therefore extend the spectrum of potentially used matrices in postmortem toxicology. For this reason, a rapid, simple and sensitive method for the extraction, determination and quantification of ten drugs of abuse from plaque using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and fully validated...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917578/emerging-biomarkers-for-cancer-immunotherapy-in-melanoma
#3
REVIEW
Margaret L Axelrod, Douglas B Johnson, Justin M Balko
The treatment and prognosis of metastatic melanoma has changed substantially since the advent of novel immune checkpoint inhibitors (ICI), agents that enhance the anti-tumor immune response. Despite the success of these agents, clinically actionable biomarkers to aid patient and regimen selection are lacking. Herein, we summarize and review the evidence for candidate biomarkers of response to ICIs in melanoma. Many of these candidates can be examined as parts of a known molecular pathway of immune response, while others are clinical in nature...
September 13, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28916100/improving-wastewater-based-epidemiology-to-estimate-cannabis-use-focus-on-the-initial-aspects-of-the-analytical-procedure
#4
Ana Causanilles, Jose Antonio Baz-Lomba, Daniel A Burgard, Erik Emke, Iria González-Mariño, Ivona Krizman-Matasic, Angela Li, Arndís S C Löve, Ann Kathrin McCall, Rosa Montes, Alexander L N van Nuijs, Christoph Ort, José B Quintana, Ivan Senta, Senka Terzic, Félix Hernandez, Pim de Voogt, Lubertus Bijlsma
Wastewater-based epidemiology is a promising and complementary tool for estimating drug use by the general population, based on the quantitative analysis of specific human metabolites of illicit drugs in urban wastewater. Cannabis is the most commonly used illicit drug and of high interest for epidemiologists. However, the inclusion of its main human urinary metabolite 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH) in wastewater-based epidemiology has presented several challenges and concentrations seem to depend heavily on environmental factors, sample preparation and analyses, commonly resulting in an underestimation...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915868/the-cedar-project-using-indigenous-specific-determinants-of-health-to-predict-substance-use-among-young-pregnant-involved-aboriginal-women
#5
Sana Z Shahram, Joan L Bottorff, Nelly D Oelke, Leanne Dahlgren, Victoria Thomas, Patricia M Spittal
BACKGROUND: Indigenous women in Canada have been hyper-visible in research, policy and intervention related to substance use during pregnancy; however, little is known about how the social determinants of health and substance use prior to, during, and after pregnancy intersect. The objectives of this study were to describe the social contexts of pregnant-involved young Indigenous women who use substances and to explore if an Indigenous-Specific Determinants of Health Model can predict substance use among this population...
September 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28915841/is-there-room-for-resilience-a-scoping-review-and-critique-of-substance-use-literature-and-its-utilization-of-the-concept-of-resilience
#6
REVIEW
Katherine Rudzinski, Peggy McDonough, Rosemary Gartner, Carol Strike
Research in the area of illicit substance use remains preoccupied with describing and analyzing the risks of people who use drugs (PWUD), however more recently there has been a drive to use a strengths-based or resilience approach as an alternative to investigating drug use. This leads us to ask: what can be known about PWUD from the point of view of resilience? The objective of this scoping review is to analyze how the concept of resilience is defined, operationalized, and applied in substance use research...
September 15, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28915346/a-review-of-chemical-spot-tests-a-presumptive-illicit-drug-identification-technique
#7
REVIEW
Morgan Philp, Shanlin Fu
Chemical 'spot' tests are a presumptive illicit drug identification technique commonly used by law enforcement, border security personnel, and forensic laboratories. The simplicity, low cost and rapid results afforded by these tests make them particularly attractive for presumptive identification globally. In this paper, we review the development of these long-established methods and discuss color test recommendations and guidelines. A search of the scientific literature revealed the chemical reactions occurring in many color tests are either not actively investigated or reported as unknown...
September 15, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28915073/internalized-homonegativity-and-substance-use-among-u-s-men-who-have-sex-with-men-only-msmo-and-men-who-have-sex-with-men-and-women-msmw
#8
William L Jeffries, Oshea D Johnson
BACKGROUND: Internalized homonegativity may promote substance use among U.S. men who have sex with men only (MSMO) and men who have sex with men and women (MSMW). However, studies have produced mixed findings, used non-representative samples, and not adequately examined MSMW. OBJECTIVES: We investigated (1) internalized homonegativity in relation to substance use and (2) the extent of temporal change in internalized homonegativity among MSMO and MSMW. METHODS: Using merged 2002, 2006-2010, and 2011-2013 cycles of the National Survey of Family Growth-a nationally representative U...
September 15, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28914663/physicians-decision-making-when-implementing-buprenorphine-with-new-patients-conjoint-analyses-of-data-from-a-cohort-of-current-prescribers
#9
Hannah K Knudsen, Michelle R Lofwall, Sharon L Walsh, Jennifer R Havens, Jamie L Studts
OBJECTIVES: Few studies have considered how providers make decisions to prescribe buprenorphine to new patients with opioid use disorder. This study examined the relative importance of patients' clinical, financial, and social characteristics on physicians' decision-making related to willingness to prescribe buprenorphine to new patients and the number of weeks of medication that they are willing to initially prescribe after induction. METHODS: A national sample of 1174 current prescribers was surveyed...
September 13, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28912635/profile-of-justice-involved-marijuana-and-other-substance-users-demographics-health-and-health-care-family-and-justice-system-experiences
#10
REVIEW
Nikki Freeman, Justin Landwehr, Tasseli McKay, James Derzon, Anupa Bir
Substance users are more likely to have co-occurring health problems, and this pattern is intensified among those involved with the criminal justice system. Interview data for 1977 incarcerated men in 5 states from the Multi-site Family Study on Incarceration, Parenting, and Partnering that was conducted between December 2008 and August 2011 were analyzed to compare pre-incarceration substance use patterns and health outcomes between men who primarily used marijuana, primarily used alcohol, primarily used other drugs, and did not use any illicit substances during that time...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28912606/profiling-of-cocaine-using-ratios-of-gc-ms-peaks
#11
Palle Villesen, Louise Stride Nielsen
Illicit cocaine seizures are often compared to each other by using gas chromatography-mass spectrometry (GC-MS) data from cocaine alkaloid compounds to determine whether two specimens originate from the same production batch or not. This can provide intelligence or investigative information at the early stages of an investigation or evidence in court. Traditional classification methods assume high stability of all alkaloids, use all of them to calculate the correlation between two profiles and use a threshold to classify samples...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911778/applications-of-isotope-ratio-mass-spectrometry-in-sports-drug-testing-accounting-for-isotope-fractionation-in-analysis-of-biological-samples
#12
Thomas Piper, Mario Thevis
The misuse of anabolic-androgenic steroids (AAS) in sports aiming at enhancing athletic performance has been a challenging matter for doping control laboratories for decades. While the presence of a xenobiotic AAS or its metabolite(s) in human urine immediately represents an antidoping rule violation, the detection of the misuse of endogenous steroids such as testosterone necessitates comparably complex procedures. Concentration thresholds and diagnostic analyte ratios computed from urinary steroid concentrations of, e...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28910186/applying-the-problem-behavior-theory-to-adolescent-drug-use-among-a-cross-sectional-sample-of-boys-participating-in-a-community-based-youth-organization
#13
Adam C Alexander, Christopher O Obong'o, Prachi Chavan, Mark W Vander Weg, Kenneth D Ward
BACKGROUND: Drug use remains an important public health concern in the United States, and understanding drug use among young adolescents is vital towards improving the health of the population. OBJECTIVE: This study applied the Problem Behavior Theory (PBT) to lifetime drug use among a cross-sectional sample of Boy Scouts (N = 770). The PBT provides a conceptual framework for identifying risk and protective factors for adolescent problem behaviors, including drug use...
September 14, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28905733/why-it-s-inappropriate-not-to-treat-incarcerated-patients-with-opioid-agonist-therapy
#14
Sarah E Wakeman
Due to the criminalization of drug use and addiction, opioid use disorder is overrepresented in incarcerated populations. Decades of evidence supports opioid agonist therapy as a highly effective treatment that improves clinical outcomes and reduces illicit opioid use, overdose death, and cost. Opioid agonist therapy has been both studied within correctional facilities and initiated prerelease. It has been found to be beneficial, yet few incarcerated persons receive this evidence-based treatment. In addition to not offering treatment initiation for those who need it, most correctional facilities forcibly withdraw stable patients from opioid agonist therapy upon their entry into the criminal justice system...
September 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28905207/role-of-vasopressin-v1a-receptor-in-%C3%A2-9-tetrahydrocannabinol-induced-cataleptic-immobilization-in-mice
#15
Nobuaki Egashira, Emi Koushi, Takayuki Myose, Akito Tanoue, Kenichi Mishima, Ryota Tsuchihashi, Junei Kinjo, Hiroyuki Tanaka, Satoshi Morimoto, Katsunori Iwasaki
RATIONALE: Cannabis is a widely used illicit substance. ∆(9)-tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to cause catalepsy in rodents. Recent studies have shown that vasopressin V1a and V1b receptors are widely distributed in the central nervous system and are capable of influencing a wide variety of brain functions such as social behavior, emotionality, and learning and memory. OBJECTIVES: The present study was designed to examine the possible involvement of V1a and V1b receptors in THC-induced catalepsy-like immobilization...
September 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28898781/thymus-atrophy-is-an-efficient-marker-of-illicit-treatment-with-dexamethasone-in-veal-calves-results-from-a-triennial-experimental-study
#16
Guia Benedetta Richelmi, Cristiana Maurella, Marzia Pezzolato, Mario Botta, Katia Varello, Danilo Pitardi, Elisa Baioni, Claudio Bellino, Antonio D'Angelo, Maria Caramelli, Elena Bozzetta
Glucocorticoids, used in a wide range of pathologies thank to their therapeutical properties, are also illegally used as growth-promoters in animal breeding even if the European Union regulates their use to protect consumers' health from the adverse effects of residues in food. The first aim of the study was to establish the applicability of two histological parameters - atrophy and cortex-medulla ratio - to detect glucocorticoids misuse in calves. The second aim was to concurrently test the potentiality of both parameters to discriminate between treated and untreated animals...
September 6, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28893086/older-african-american-homeless-experienced-smokers-attitudes-toward-tobacco-control-policies-results-from-the-hope-home-study
#17
Maya Vijayaraghavan, Pamela Olsen, John Weeks, Karma McKelvey, Claudia Ponath, Margot Kushel
PURPOSE: To examine attitudes toward tobacco control policies among older African American homeless-experienced smokers. APPROACH: A qualitative study. SETTING: Oakland, California. PARTICIPANTS: Twenty-two African American older homeless-experienced smokers who were part of a longitudinal study on health and health-related outcomes (Health Outcomes of People Experiencing Homelessness in Older Middle Age Study). METHOD: We conducted in-depth, semistructured interviews with each participant to explore beliefs and attitudes toward tobacco use and cessation, barriers to smoking cessation, and attitudes toward current tobacco control strategies including raising cigarette prices, smoke-free policies, and graphic warning labels...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28890649/recent-alcohol-tobacco-and-substance-use-variations-between-rural-and-urban-middle-and-high-school-students
#18
Jacob C Warren, K Bryant Smalley, K Nikki Barefoot
The use of addictive substances by adolescents is a major public health concern; however, rural vs. urban variations are poorly understood. The purpose of the current study was to examine rural-urban differences in the prevalence of recent use of 11 substances in grades 6-12 in a statewide sample of students from the Georgia Student Health Survey II (n = 513,909). We found that rural-urban differences in substance use depend largely upon grade level, with rural middle school students demonstrating higher rates of alcohol, smoking tobacco, and chewing tobacco use, and urban high school students demonstrating higher rates of illicit drugs...
2017: Journal of Child & Adolescent Substance Abuse
https://www.readbyqxmd.com/read/28889058/the-relationship-between-family-based-adverse-childhood-experiences-and-substance-use-behaviors-among-a-diverse-sample-of-college-students
#19
Myriam Forster, Timothy J Grigsby, Christopher J Rogers, Stephanie M Benjamin
INTRODUCTION: Research suggests that college students are an especially vulnerable subset of the population for substance use and misuse. However, despite evidence of the high prevalence of adverse childhood experiences (ACE) among students and the link between family-based ACE and substance use among older adults, this relationship remains understudied in college populations. Moreover, whether ACE represents a shared risk across substance use behaviors and ethnic groups is unknown. METHODS: Data are student responses (n=2953) on the 2015 American College Health Association's National College Health Assessment II (ACHA-NCHA II) administered at one of the largest, most diverse public universities in California...
September 1, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28888099/polydrug-use-and-its-association-with-drug-treatment-outcomes-among-primary-heroin-methamphetamine-and-cocaine-users
#20
Linwei Wang, Jeong Eun Min, Emanuel Krebs, Elizabeth Evans, David Huang, Lei Liu, Yih-Ing Hser, Bohdan Nosyk
BACKGROUND: Polydrug use may challenge effective treatment for substance use disorders. We evaluate whether secondary substance use modifies the association between treatment and primary drug use among primary heroin, cocaine and methamphetamine (MA) users. METHODS: Data were obtained from prospective cohort studies on people who use illicit drugs (PWUD) in California, USA. Using repeated monthly data on self-reported secondary substance use (heroin, cocaine, MA, alcohol or marijuana; ≥1day in a month), primary drug use (≥1day in a month), and treatment participation, collected via timeline follow-back, we fitted generalized linear mixed multiple regression models controlling for potential confounders to examine the interactions between treatment and secondary substance use on the odds of primary heroin, cocaine and MA use, respectively...
September 6, 2017: International Journal on Drug Policy
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