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https://www.readbyqxmd.com/read/28635347/ketamine-and-international-regulations
#1
Yanhui Liao, Yi-Lang Tang, Wei Hao
BACKGROUND: Ketamine is an anesthetic commonly used in low-income countries and has recently been shown to be effective for treatment-resistant depression. However, the illicit manufacturing, trafficking, and nonmedical use of ketamine are increasing globally, and its illicit use poses major public health challenges in many countries. OBJECTIVES: To review the nonmedical use of ketamine in selected countries and its regulatory control. METHODS: We conducted a review of literature identified from searches of the China National Knowledge Infrastructure (CNKI) (1979-2016) and PubMed databases, supplemented by additional references identified by the authors...
February 13, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28633314/qualitative-identification-of-fentanyl-analogs-and-other-opioids-in-postmortem-cases-by-uhplc-ion-trap-msn
#2
Elisa N Shoff, M Elizabeth Zaney, Joseph H Kahl, George W Hime, Diane M Boland
Since 2013, the Miami-Dade County Medical Examiner Department has experienced an increase in the number of opioid-related deaths. The majority of cases coincided with the introduction of fentanyl into the local heroin supply. From 2014 to 2015, Miami-Dade County experienced a near 600% increase in fentanyl-related deaths, followed by an additional 200% increase in 2016. In 2015, two novel fentanyl analogs were identified in medical examiner cases: beta-hydroxythiofentanyl and acetyl fentanyl. In 2016, four additional fentanyl analogs emerged: para-fluoroisobutyryl fentanyl, butyryl fentanyl, furanyl fentanyl and carfentanil, as well as the synthetic opioid U-47700...
June 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28633054/men-and-women-with-psychosis-and-the-impact-of-illness-duration-on-sex-differences-the-second-australian-national-survey-of-psychosis
#3
Mary-Claire Hanlon, Linda E Campbell, Natalie Single, Clare Coleman, Vera A Morgan, Susan M Cotton, Helen J Stain, David J Castle
We aimed to examine and compare sex-differences in people receiving treatment for psychotic illnesses in community settings, based on long or short duration of illness; expecting association between longer illness-duration and worse outcomes in women and men. Clinical, demographic and service-use data from the Survey of High Impact Psychosis were analysed by sex and duration of illness (≤5 years; ≥6 years), using independent t-tests, chi-square tests, one-way ANOVA, and Cramer's V. Of the 1825 participants, 47% had schizophrenia, 17...
June 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28630559/drug-policy-and-indigenous-peoples
#4
Julian Burger, Mary Kapron
This paper identifies the principal concerns of indigenous peoples with regard to current international treaties on certain psychoactive substances and policies to control and eradicate their production, trafficking, and sale. Indigenous peoples have a specific interest in the issue since their traditional lands have become integrated over time into the large-scale production of coca, opium poppy, and cannabis crops, in response to high demand from the American and European markets, among others. As a consequence, indigenous peoples are persecuted because of their traditional use of these and other plant-based narcotics and hallucinogens...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28627903/predictors-of-substance-use-in-youth-with-borderline-personality-disorder
#5
Franco Scalzo, Carol A Hulbert, Jennifer K Betts, Sue M Cotton, Andrew M Chanen
Concomitant substance misuse in adults with borderline personality disorder (BPD) is associated with a more severe course of illness and poorer outcomes. Previous research has found an association between the number of borderline personality features and substance misuse in community samples. This study examined the relationship between substance use and severity of BPD in youth presenting for the first time for treatment (first presentation) of BPD. Participants were 117 help-seeking youth aged 15-25 years (93 females; Mage = 19...
June 19, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28624673/a-geographical-analysis-of-trafficking-on-a-popular-darknet-market
#6
Julian Broséus, Damien Rhumorbarbe, Marie Morelato, Ludovic Staehli, Quentin Rossy
Cryptomarkets are online marketplaces, located on the darknet, that facilitate the trading of a variety of illegal goods, mostly drugs. While the literature essentially focus on drugs, various other goods and products related to financial or identity fraud, firearms, counterfeit goods, as well as doping products are also offered on these marketplaces. Through the analysis of relevant data collected on a popular marketplace in 2014-2015, Evolution, this research provides an analysis of the structure of trafficking (types and proportions of products, number of vendors and shipping countries)...
June 4, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28624604/user-characteristics-and-effect-profile-of-butane-hash-oil-an-extremely-high-potency-cannabis-concentrate
#7
Gary C K Chan, Wayne Hall, Tom P Freeman, Jason Ferris, Adrian B Kelly, Adam Winstock
BACKGROUND: Recent reports suggest an increase in use of extremely potent cannabis concentrates such as Butane Hash Oil (BHO) in some developed countries. The aims of this study were to examine the characteristics of BHO users and the effect profiles of BHO. DESIGN: Anonymous online survey in over 20 countries in 2014 and 2015. Participants aged 18 years or older were recruited through onward promotion and online social networks. The overall sample size was 181,870...
June 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28624602/the-mediating-effects-of-depressive-symptoms-and-sleep-quality-on-the-relationship-between-the-non-medical-use-of-prescription-drugs-and-suicidal-behaviors-among-chinese-adolescents
#8
Juan Wang, Yan Xu, Lan Guo, Jian-Xiong Deng, Jing-Hui Huang, Guo-Liang Huang, Xue Gao, Hong Wu, Si-Yuan Pan, Ci-Yong Lu
BACKGROUND: The nature of the relationship between the non-medical use of prescription drugs (NMUPD) and suicide has not been clearly elucidated. Some studies have suggested that the relationship between substance use and suicidal ideation may be spurious and could be explained by other variables. METHODS: A school-based cross-sectional study was performed in Guangzhou. A total of 5853 students completed questionnaires and were included in the study. NMUPD, alcohol use, illicit drug use, depressive symptoms, sleep quality, and suicidal behaviors were assessed...
June 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28622100/prevalence-of-substance-use-among-middle-school-aged-e-cigarette-users-compared-with-cigarette-smokers-non-users-and-dual-users-implications-for-primary-prevention
#9
Alfgeir L Kristjansson, Michael J Mann, Megan L Smith
BACKGROUND: To compare the prevalence of substance use in e-cigarette (EC) only users with combustible cigarette (CC) only users, dual users, and non-users in a large sample of middle school-aged adolescents. METHODS: Population-based cross-sectional school survey conducted in 15 middle schools in three counties in West Virginia in the US between October and December of 2015 (N = 6,547, girls = 49.6%. Response rate 84.7%). RESULTS: Approximately 4...
June 16, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28622067/opioid-involved-overdose-among-male-afghanistan-iraq-era-u-s-military-veterans-a-multidimensional-perspective
#10
Alex S Bennett, Luther Elliott, Andrew Golub, Brett Wolfson-Stofko, Honoria Guarino
BACKGROUND: Mirroring nationwide trends in a broad range of U.S. populations, an alarming number of Afghanistan/Iraq-era U.S. Military veterans have experienced opioid-related overdoses. A growing body of research has examined the proximal behaviors that can precipitate an overdose; considerably less is known about more distal physiological, psychosocial and structural influences on these risk behaviors. OBJECTIVES: This study adopts a multidimensional approach to better understand opioid-related overdose among U...
June 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28621645/patterns-and-factors-of-problematic-marijuana-use-in-the-canadian-population-evidence-from-three-cross-sectional-surveys
#11
W I Andrew Bonner, Mustafa Andkhoie, Charlene Thompson, Marwa Farag, Michael Szafron
OBJECTIVES: The objectives of this study are to describe marijuana use in Canada and explore factors associated with problematic use. METHODS: Data from the 2010-2012 circulations of the Canadian Alcohol and Drug Use Monitoring Survey were used to create three logistic regression models for the purposes of identifying and comparing factors associated with the degree of marijuana use, as determined via the WHO Alcohol, Smoking and Substance Abuse Involvement Screening Test (non-problematic, problematic) and European Monitoring Centre for Drugs and Drug Addiction (experiential, recent, current) methods...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28619473/cocaine-adulteration
#12
REVIEW
Oliver Kudlacek, Tina Hofmaier, Anton Luf, Felix P Mayer, Thomas Stockner, Constanze Nagy, Marion Holy, Michael Freissmuth, Rainer Schmid, Harald H Sitte
Cocaine is a naturally occurring and illicitly used psychostimulant drug, which exerts its activity at monoaminergic neurotransmitter transporters. These transporters mediate the reuptake of the monoamines dopamine, serotonin and norepinephrine and are blocked by cocaine. The increase of monoamines in the extracellular space is the phenomenon underlying the drug effects that cocaine users seek. Currently, it is one of the most important illicit drugs on the European market. However, this increase in monoamines is also the underlying cause for the development of addiction and a number of severe side effects...
June 12, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28617565/psychotropic-medications-in-swedish-homicide-victims-and-offenders-a-forensic-toxicological-case-control-study-of-adherence-and-recreational-use
#13
Jonatan Hedlund, Jonas Forsman, Joakim Sturup, Thomas Masterman
OBJECTIVE: We aimed to assess the extent to which adherence to, and recreational use of, psychotropic medications influence the risk of homicide offending and victimization. METHODS: We conducted a population-based case-control study by way of linking a nationwide registry of dispensed prescriptions with a forensic-toxicological database. Homicide victims (n = 200) and offenders (n = 105) were identified for the years 2007-2009 and vehicle-accident controls (n = 1,643) for the years 2006-2013...
June 6, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28616897/alcohol-and-other-substance-use-among-a-sample-of-young-people-in-the-solomon-islands
#14
Brendan Quinn, Elizabeth Peach, Cassandra J C Wright, Megan S C Lim, Lisa Davidson, Paul Dietze
OBJECTIVE: Investigate alcohol and other substance use, with a focus on harmful alcohol use patterns, among young people in the Solomon Islands. METHODS: A structured, interviewer-administered questionnaire was administered to respondents aged 15-24 years across four of the country's provinces in late 2015. RESULTS: Four hundred young people completed the questionnaire across urban, peri-urban and rural communities. The most common substances ever used by participants were betel nut (94%), licit/store-bought and/or illicit alcohol (79%) and tobacco (76%)...
June 14, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28616882/bullying-among-18-to-23-year-old-women-in-2013
#15
Natalie Townsend, Jennifer Powers, Deborah Loxton
OBJECTIVE: To identify the prevalence of bullying among women aged 18-23 in 2013, and to describe the demographic characteristics, health and risk factors of those who experienced bullying. METHODS: Cross-sectional analysis using data from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health, a nationally representative cohort (n=16,801). RESULTS: More than one-quarter of women (28.4%) indicated they had never been bullied, 53...
June 14, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28615950/utilizing-big-data-and-twitter-to-discover-emergent-online-communities-of-cannabis-users
#16
Peter Baumgartner, Nicholas Peiper
Large shifts in medical, recreational, and illicit cannabis consumption in the United States have implications for personalizing treatment and prevention programs to a wide variety of populations. As such, considerable research has investigated clinical presentations of cannabis users in clinical and population-based samples. Studies leveraging big data, social media, and social network analysis have emerged as a promising mechanism to generate timely insights that can inform treatment and prevention research...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28614161/multiple-cerebral-infarcts-in-a-young-patient-associated-with-marijuana-use
#17
Leila Costa Volpon, Camila Lacerda Muniz de Melo Sousa, Silvia Keiko Kavaguti Moreira, Sara Reis Teixeira, Ana Paula de Carvalho Panzeri Carlotti
: Cerebrovascular events associated with marijuana use have been reported previously. This association is plausible, but not well-established yet. A 14-year-old girl, long-term heavy cannabis user, presented with generalized tonic-clonic seizures and decreased level of consciousness a few hours after smoking cannabis. Brain magnetic resonance imaging showed multiple areas of acute, subacute and chronic ischemic lesions in the left frontal lobe, basal ganglia, and corpus callosum. History of other illicit drug use and other known causes of stroke were ruled out...
June 13, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28609749/fatal-and-non-fatal-opioid-overdose-in-opioid-dependent-patients-treated-with-methadone-buprenorphine-or-implant-naltrexone
#18
Erin Kelty, Gary Hulse
BACKGROUND: Illicit opioid use is associated with high rates of fatal and non-fatal opioid overdose. This study aims to compare rates of fatal and serious but non-fatal opioid overdose in opioid dependent patients treated with methadone, buprenorphine or implant naltrexone, and to identify risk factors for fatal opioid overdose. METHODS: Opioid dependent patients treated with methadone (n=3515), buprenorphine (n=3250) or implant naltrexone (n=1461) in Western Australia for the first time between 2001 and 2010, were matched against state mortality and hospital data...
June 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28609721/broken-lives-fights-fractures-and-motor-vehicle-accidents-among-heroin-users-entering-detoxification
#19
Michael D Stein, Bradley J Anderson, Genie L Bailey
BACKGROUND: The lives of persons who use illicit substances are filled with physical adversities and negative outcomes. OBJECTIVES: The purpose of this study was to determine: 1) the frequency of substance-related fights, fractures, and driving accidents in the past year among heroin users entering an inpatient detoxification program, and 2) to determine demographic and recent substance use factors associated with the most common of these physical traumas. METHODS: Between May 2015 and December 2015, we surveyed 433 persons entering a short-term inpatient detoxification program that reported heroin use in the last month and recorded their experiences of physical traumas in the last year...
June 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28609661/the-use-of-pesticides-in-belgian-illicit-indoor-cannabis-plantations
#20
Eva Cuypers, Wouter Vanhove, Joachim Gotink, Arne Bonneure, Patrick Van Damme, Jan Tytgat
Cannabis (Cannabis spp.) use and cultivation continue to increase in many (European) countries. The illicit indoor cannabis plantations that supply Belgian and European cannabis markets create problems and concerns about health and safety of intervention staff, dismantling companies, the direct environment of cannabis plantations and, eventually, of cannabis users. Main risks may come from pesticide residues on plants, cultivation infrastructure and materials; left-over plant growth-promoting substances; mycotoxins from fungal pathogens on harvested plants; and/or high levels of cannabinoids in cannabis plant parts for consumption...
May 25, 2017: Forensic Science International
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