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https://www.readbyqxmd.com/read/29245119/dceus-based-focal-parametric-perfusion-imaging-of-microvessel-with-single-pixel-resolution-and-high-contrast
#1
Diya Wang, Mengnan Xiao, Hong Hu, Yu Zhang, Zhe Su, Shanshan Xu, Yujin Zong, Mingxi Wan
This study aimed to develop a focal microvascular contrast-enhanced ultrasonic parametric perfusion imaging (PPI) scheme to overcome the tradeoff between the resolution, contrast, and accuracy of focal PPI in the tumor. Its resolution was limited by the low signal-to-clutter ratio (SCR) of time-intensity-curves (TICs) induced by multiple limitations, which deteriorated the accuracy and contrast of focal PPI. The scheme was verified by the in-vivo perfusion experiments. Single-pixel TICs were first extracted to ensure PPI with the highest resolution...
December 2, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29245113/the-temporal-relationship-between-activity-of-the-pelvic-floor-muscles-and-motion-of-selected-urogenital-landmarks-in-healthy-nulliparous-women
#2
Stéphanie Thibault-Gagnon, Cindy Auchincloss, Ryan Graham, Linda McLean
AIMS: The purpose of this study was to investigate the relationship between pelvic floor muscle (PFM) electromyographic (EMG) activation and urogenital landmark motion measured using 2D transperineal ultrasound (US) imaging. METHODS: Eight healthy, nulliparous women performed maximum voluntary PFM contractions while EMG and transperineal US images were acquired simultaneously. Changes in the levator plate length (LPL), bladder neck (BN) position and urethral position were determined by visual inspection...
December 6, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29245057/a-new-randomized-kaczmarz-based-kernel-canonical-correlation-analysis-algorithm-with-applications-to-information-retrieval
#3
Jia Cai, Yi Tang
Canonical correlation analysis (CCA) is a powerful statistical tool for detecting the linear relationship between two sets of multivariate variables. Kernel generalization of it, namely, kernel CCA is proposed to describe nonlinear relationship between two variables. Although kernel CCA can achieve dimensionality reduction results for high-dimensional data feature selection problem, it also yields the so called over-fitting phenomenon. In this paper, we consider a new kernel CCA algorithm via randomized Kaczmarz method...
December 2, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29245040/characterising-the-online-weapons-trafficking-on-cryptomarkets
#4
Damien Rhumorbarbe, Denis Werner, Quentin Gilliéron, Ludovic Staehli, Julian Broséus, Quentin Rossy
Weapons related webpages from nine cryptomarkets were manually duplicated in February 2016. Information about the listings (i.e. sales proposals) and vendors' profiles were extracted to draw an overview of the actual online trafficking of weapons. Relationships between vendors were also inferred through the analysis of online digital traces and content similarities. Weapons trafficking is mainly concentrated on two major cryptomarkets. Besides, it accounts for a very small proportion of the illicit trafficking on cryptomarkets compared to the illicit drugs trafficking...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29244994/do-perceived-needs-affect-willingness-to-use-traditional-chinese-medicine-for-survivorship-care-among-chinese-cancer-survivors-a-cross-sectional-survey
#5
Lingyun Sun, Yufei Yang, Emily Vertosick, SungHwa Jo, Guilan Sun, Jun J Mao
Purpose We aimed to quantify Chinese cancer survivors' perceived needs for survivorship care and to evaluate whether these needs could impact their willingness to use traditional Chinese medicine (TCM). Methods We conducted a cross-sectional survey with members of the Beijing Anti-Cancer Association in China. We measured perceived needs with the seven-item Brief Chinese Cancer Survivorship Needs Scale that assesses psychological, functional, nutritional, social, body image, pain, and symptom needs. The outcome variable was willingness to use TCM for survivorship care...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244972/evaluating-an-ipad-app-in-measuring-wound-dimension-a-pilot-study
#6
P C B Khong, M S W Yeo, C C Goh
OBJECTIVE: This pilot study tested the reliability, validity and sensitivity of an innovative prototype iPad app, WoundAide, developed to measure wound dimension (length, width and surface area) using image analysis. METHOD: A prospective evaluation was conducted comparing WoundAide (WA) with two gold standard instruments, Wound Zoom (WZ) and Visitrak (VT). The study was conducted in a tertiary hospital in Singapore. Patients were recruited after obtaining local ethics approval...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244869/lspr-mediated-high-axial-resolution-fluorescence-imaging-on-a-silver-nanoparticle-sheet
#7
Eiji Usukura, Yuhki Yanase, Ayumi Ishijima, Thasaneeya Kuboki, Satoru Kidoaki, Koichi Okamoto, Kaoru Tamada
This paper reports our original technique for visualizing cell-attached nanointerfaces with extremely high axial resolution using homogeneously excited localized surface plasmon resonance (LSPR) on self-assembled silver nanoparticle sheets. The LSPR sheet can confine and enhance the fluorescence at the nanointerface, which provides high signal-to-noise ratio images of focal adhesion at the cell-attached interface. The advantage of this LSPR-assisted technique is its usability, which provides comparable or higher-quality nanointerfacial images than TIRF microscopy, even under epifluorescence microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/29244749/serum-levels-of-s100b-and-nse-proteins-in-patients-with-non-transfusion-dependent-thalassemia-as-biomarkers-of-brain-ischemia-and-cerebral-vasculopathy
#8
Aikaterini Kanavaki, Konstantinos Spengos, Maria Moraki, Polyxeni Delaporta, Catherine Kariyannis, Ioannis Papassotiriou, Antonis Kattamis
Patients with non-transfusion-dependent thalassemia (NTDT) are at risk of developing brain ischemia. Transcranial Doppler (TCD) has been established as a useful screening tool of cerebrovascular disease in patients with sickle cell disease. Proteins neuron specific enolase (NSE) and S100B are biomarkers that reflect CNS injury. The purpose of this study is to evaluate cerebral vessel vasculopathy and brain damage in NTDT patients using non-invasive methods as TCD and measurement serum levels of NSE and S100B...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244617/differentiation-of-high-grade-from-low-grade-astrocytoma-improvement-in-diagnostic-accuracy-and-reliability-of-pharmacokinetic-parameters-from-dce-mr-imaging-by-using-arterial-input-functions-obtained-from-dsc-mr-imaging
#9
Sung-Hye You, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Sung-Hye Park, Jae-Kyung Won, Il Han Kim, Soon Tae Lee, Hye Jeong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Purpose To evaluate whether arterial input functions (AIFs) derived from dynamic susceptibility-contrast (DSC) magnetic resonance (MR) imaging, or AIFDSC values, improve diagnostic accuracy and reliability of the pharmacokinetic (PK) parameters of dynamic contrast material-enhanced (DCE) MR imaging for differentiating high-grade from low-grade astrocytomas, compared with AIFs obtained from DCE MR imaging (AIFDCE). Materials and Methods This retrospective study included 226 patients (138 men, 88 women; mean age, 52...
December 15, 2017: Radiology
https://www.readbyqxmd.com/read/29244247/2d-or-not-2d-testing-the-utility-of-2d-vs-3d-landmark-data-in-geometric-morphometrics-of-the-sculpin-subfamily-oligocottinae-pisces-cottoidea
#10
Thaddaeus J Buser, Brian L Sidlauskas, Adam P Summers
We contrast 2D vs. 3D landmark-based geometric morphometrics in the fish subfamily Oligocottinae by using 3D landmarks from CT-generated models and comparing the morphospace of the 3D landmarks to one based on 2D landmarks from images. The 2D and 3D shape variables capture common patterns across taxa, such that the pairwise Procrustes distances among taxa correspond and the trends captured by principal component analysis are similar in the xy plane. We use the two sets of landmarks to test several ecomorphological hypotheses from the literature...
December 15, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29244231/differences-in-regional-grey-matter-volumes-in-currently-ill-patients-with-anorexia-nervosa
#11
Andrea Phillipou, Susan Lee Rossell, Caroline Gurvich, David Jonathan Castle, Larry Allen Abel, Richard Grant Nibbs, Matthew Edward Hughes
Neurobiological findings in anorexia nervosa (AN) are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to the inconsistencies reported. The aim of this study was to improve on these methodologies by utilising voxel based morphometry (VBM) analysis with the use of diffeomorphic anatomic registration through an exponentiated lie algebra algorithm (DARTEL), in a relatively large group of individuals with AN. Twenty-six individuals with AN and 27 healthy controls underwent a T1-weighted magnetic resonance imaging (MRI) scan...
December 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29244222/diffusion-weighted-imaging-features-of-breast-tumours-and-the-surrounding-stroma-reflect-intrinsic-heterogeneous-characteristics-of-molecular-subtypes-in-breast-cancer
#12
Ming Fan, Ting He, Peng Zhang, Hu Cheng, Juan Zhang, Xin Gao, Lihua Li
Breast cancer heterogeneity is the main obstacle preventing the identification of patients with breast cancer with poor prognoses and treatment responses; however, such heterogeneity has not been well characterized. The purpose of this retrospective study was to reveal heterogeneous patterns in the apparent diffusion coefficient (ADC) signals in tumours and the surrounding stroma to predict molecular subtypes of breast cancer. A dataset of 126 patients with breast cancer, who underwent preoperative diffusion-weighted imaging (DWI) on a 3...
December 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29244179/sedaxane-use-of-nuclear-receptor-transactivation-assays-toxicogenomics-and-toxicokinetics-as-part-of-a-mode-of-action-framework-for-rodent-liver-tumors
#13
Richard C Peffer, David E Cowie, Richard A Currie, Daniel J Minnema
Experimental data demonstrate a mode of action (MOA) for liver tumors in male rats and mice treated with sedaxane that starts with activation of CAR, followed by altered expression of CAR-responsive genes, increased cell proliferation, and eventually clonal expansion of preneoplastic cells, leading to the development of altered foci and tumors. This MOA is non-relevant to human risk assessments. Methods and results in the MOA work for sedaxane illustrate promising directions that future MOA studies may be able to employ, in the spirit of "Tox21" and reduction of in vivo animal use: 1) currently available in vitro CAR and PXR reporter assays demonstrated that sedaxane is a direct CAR activator in mice and rats, and a weak PXR activator in rats; 2) mouse liver microarray results compared to a published CAR biomarker signature (based on 83 genes) showed a clear, statistical match, and a lack of correlation to similar biomarker signatures for AhR, PPARα, and STAT5B; 3) Ki67 immunohistochemistry and zonal image analysis showed significant increases in this marker of cell proliferation in mouse liver, without the need to dose a DNA labelling agent; and 4) toxicokinetic analysis of Cmax levels of sedaxane in blood showed a marked species difference between mice and rats that helps to explain differences in sensitivity to sedaxane...
December 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29244155/differential-rpa-1-and-rad-51-recruitment-in-vivo-throughout-the-c-elegans-germline-as-revealed-by-laser-microirradiation
#14
Emily Koury, Kailey Harrell, Sarit Smolikove
Studies of the repair pathways associated with DNA double strand breaks (DSBs) are numerous, and provide evidence for cell-cycle specific regulation of homologous recombination (HR) by the regulation of its associated proteins. Laser microirradiation is a well-established method to examine in vitro kinetics of repair and allows for live-imaging of DSB repair from the moment of induction. Here we apply this method to whole, live organisms, introducing an effective system to analyze exogenous, microirradiation-induced breaks in the Caenorhabditis elegans germline...
December 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29244081/atrial-fibrillation-type-matters-greater-infarct-volume-and-worse-neurological-defects-seen-in-acute-cardiogenic-cerebral-embolism-due-to-persistent-or-permanent-rather-than-paroxysmal-atrial-fibrillation
#15
Osamu Inaba, Yasuteru Yamauchi, Masahiro Sekigawa, Naoyuki Miwa, Junji Yamaguchi, Yasutoshi Nagata, Toru Obayashi, Takamichi Miyamoto, Tomoyuki Kamata, Mitsuaki Isobe, Masahiko Goya, Kenzo Hirao
Aims: Some studies have shown that the type of atrial fibrillation (AF), whether paroxysmal AF (PAF) or persistent or permanent AF (PeAF), affects the incidence of ischaemic stroke. This study sought to determine the relationship between the AF pattern and the severity and brain volume of infarction in an AF population including transient ischaemic attack (TIA) patients. Methods and results: This was a retrospective observational study. We studied 161 consecutive patients who were admitted to our stroke care unit with cardiogenic embolism or TIA related to non-valvular AF (age 79 ± 9...
December 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29244020/association-between-structural-and-functional-brain-alterations-in-drug-free-patients-with-schizophrenia-a-multimodal-meta-analysis
#16
Xin Gao, Wenjing Zhang, Li Yao, Yuan Xiao, Lu Liu, Jieke Liu, Siyi Li, Bo Tao, Chandan Shah, Qiyong Gong, John A Sweeney, Su Lui
BACKGROUND: Neuroimaging studies have shown both structural and functional abnormalities in patients with schizophrenia. Recently, studies have begun to explore the association between structural and functional grey matter abnormalities. By conducting a meta-analysis on morphometric and functional imaging studies of grey matter alterations in drug-free patients, the present study aims to examine the degree of overlap between brain regions with anatomic and functional changes in patients with schizophrenia...
December 15, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29243908/thin-film-nanocomposite-membrane-with-the-minimum-amount-of-mof-by-the-langmuir-schaefer-technique-for-nanofiltration
#17
Marta Navarro, Javier Benito, Lorena Paseta, Ignacio Gascón, Joaquin Coronas, Carlos Téllez
An innovative procedure for positioning a monolayer of hydrophilic metal-organic framework (MOF) MIL-101(Cr) nanoparticles (NPs) in thin film nanocomposite (TFN) membranes has been implemented by transferring a Langmuir-Schaefer (LS) film of the MOF in between the polyamide thin layer at the top and the cross-linked asymmetric polyimide (P84®) support at the bottom. The presence and layout of the LS-MIL-101(Cr) monolayer in the TFN membrane was confirmed by STEM-HAADF images, and XPS, EDS, EELS and AFM analysis...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243907/strategy-of-metal-polymer-composite-stent-to-accelerate-biodegradation-of-iron-based-biomaterials
#18
Yongli Qi, Haiping Qi, Yao He, Wenjiao Lin, Pei-Ze Li, Li Qin, Yiwen Hu, Liping Chen, Qingsong Liu, Hongtao Sun, Qiong Liu, Gui Zhang, Shuquan Cui, Jun Hu, Lin Yu, Deyuan Zhang, Jiandong Ding
The new principle and technique to tune biodegradation rates of biomaterials is one of keys to development of regenerative medicine and next-generation biomaterials. Biodegradable stents are new-generation medical devices applied in percutaneous coronary intervention etc. Recently, both corrodible metals and degradable polymers have drawn much attention in biodegradable stents or scaffolds. It is, however, a dilemma to achieve good mechanical properties and appropriate degradation profiles. Herein, we put forward a metal-polymer composite strategy to achieve both...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243773/evaluation-of-maxillary-sinus-septa-a-retrospective-clinical-study-with-cone-beam-computerized-tomography-cbct
#19
T Talo Yildirim, G-N Güncü, M Colak, S Nares, T-F Tözüm
OBJECTIVE: To determine the prevalence, height, location, orientation, and type of maxillary sinus septa in atrophic, non-atrophic, and partially atrophic maxillary segments using cone beam computerized tomography (CBCT). PATIENTS AND METHODS: This cross-sectional study was conducted on a retrospective evaluation of CBCT images of 1000 maxillary sinus with 500 subjects from December 2009 to December 2012. The differences among gender, left and right side of maxillary sinus, type of crest and feature of septa were statistically analyzed...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243681/conservative-management-of-large-mandibular-dentigerous-cysts-with-a-novel-approach-for-follow-up-two-case-reports
#20
Ieva Gendviliene, Paul Legrand, Laura Ferreira Pinheiro Nicolielo, Deepti Sinha, Yannick Spaey, Constantinus Politis, Reinhilde Jacobs
BACKGROUND: Dentigerous cysts are odontogenic cysts of the jaws accounting for approximately 24% of all epithelium-lined jaw cysts. Rarely, these cysts can become extremely large causing additional symptoms, while challenging treatment. This article represents a novel approach for radiological treatment follow up of large dentigerous cysts. MATERIAL AND METHODS: Dentigerous cysts were treated by marsupialization, using dedicated obturators and enucleation of the cyst afterwards...
2017: Stomatologija
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