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densitometry

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https://www.readbyqxmd.com/read/28549020/lung-density-and-pulmonary-artery-diameter-are-predictors-of-pulmonary-hypertension-in-systemic-sclerosis
#1
Margreet E Bakker, Maarten K Ninaber, Jan Stolk, Lucia J M Kroft, Anne A Schouffoer, Jeska K de Vries Bouwstra, Suzanne E van Wijngaarden, Berend C Stoel
PURPOSE: The aim was to evaluate computed tomography (CT)-measured pulmonary artery diameter (PAD) and lung density as predictors of pulmonary hypertension (PH) in subjects with systemic sclerosis (SSc). We compared these PAD values with normal values and between SSc subgroups with PH and/or interstitial lung disease (ILD). We investigated whether PAD predicts PH and whether lung densitometry, by using the 85th percentile density value (Perc85) as a measure for ILD, can predict PH. MATERIALS AND METHODS: PAD and Perc85 were measured in axial CT scans and compared between 54 SSc and 76 control subjects...
May 25, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28548312/vitamin-d-dependent-rickets-type-1b-25-hydroxylase-deficiency-a-rare-condition-or-a-misdiagnosed-condition
#2
Molin A, Wiedemann A, Demers N, Kaufmann M, Do Cao J, Mainard L, Dousset B, Journeau P, Abeguile G, Coudray N, Mittre H, Richard N, Weryha G, Sorlin A, Jones G, Kottler Ml, Feillet F
Vitamin D requires a two-step activation by hydroxylation: the first step is catalyzed by hepatic 25-hydroxylase (CYP2R1, 11p15.2), and the second one is catalyzed by renal 1α-hydroxylase (CYP27B1, 12q13.1), which produces the active hormonal form of 1,25-(OH)2 D. Mutations of CYP2R1 have been associated with Vitamin D-dependent rickets type 1B (VDDR1B), a very rare condition that has only been reported to affect 4 families to date. We describe 7 patients from two unrelated families who presented with homozygous loss-of-function mutations of CYP2R1...
May 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28539735/pharmacognostic-specification-chlorogenic-acid-content-and-in-vitro-antioxidant-activities-of-lonicera-japonica-flowering-bud
#3
Chayanon Chaowuttikul, Chanida Palanuvej, Nijsiri Ruangrungsi
BACKGROUND: Lonicera japonica Thunb. or Japanese Honeysuckle has been widely used in traditional medicine for antipyretic. OBJECTIVE: To establish the pharmacognostic specification of L. japonica flowering bud in Thailand and to determine its chlorogenic acid content and in vitro antioxidant activities. MATERIALS AND METHODS: Dried L. japonica flowering bud from 15 various herbal drugstores throughout Thailand were investigated for pharmacognostic specification...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539676/results-from-polish-spondyloarthritis-initiative-registry-polspi-methodology-and-data-from-the-first-year-of-observation
#4
Zofia Guła, Tacjana Barczyńska, Marek Brzosko, Jerzy Gąsowski, Sławomir Jeka, Katarzyna Jodłowska-Cicio, Beata Kwaśny-Krochin, Piotr Leszczyński, Łukasz Lubiński, Katarzyna Łosińska, Katarzyna Pawlak-Buś, Hanna Przepiera-Będzak, Włodzimierz Samborski, Małgorzata Schlabs, Maciej Siedlar, Dorota Sikorska, Jerzy Świerkot, Małgorzata Węgierska, Piotr Wiland, Mariusz Korkosz
OBJECTIVES: Report on one-year results from the Polish Spondyloarthritis Initiative registry (PolSPI), containing the cross-sectional analysis of clinical and imaging data as well as database methodology. MATERIAL AND METHODS: The PolSPI registry includes patients with axial (axSpA) and peripheral (perSpA) spondyloarthritis according to ASAS classification criteria, and/or patients with ankylosing spondylitis according to modified New York criteria, psoriatic arthritis according to CASPAR criteria, arthropathy in inflammatory bowel disease, reactive arthritis, juvenile spondyloarthritis or undifferentiated spondyloarthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28528120/objective-evaluation-of-corneal-and-lens-clarity-in-children-with-type-1-diabetes-mellitus
#5
Kemal Tekin, Merve Inanc, Erdal Kurnaz, Elvan Bayramoglu, Emre Aydemir, Mustafa Koc, Zehra Aycan
PURPOSE: To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled Type 1 DM and to compare the results obtained with those in healthy children. DESIGN: Cross-sectional prospective study. METHODS: This multicenter study enrolled 56 patients with DM and 51 control subjects. The duration of DM and the glycosylated hemoglobin (HbA1c) levels of the patients in the DM group were recorded...
May 17, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28522766/ontogeny-of-myosin-isoform-expression-and-prehensile-function-in-the-tail-of-the-gray-short-tailed-opossum-monodelphis-domestica
#6
Dylan R Thomas, Brad A Chadwell, Gary R Walker, Julio E Budde, John L VandeBerg, Michael T Butcher
Terrestrial opossums use their semi-prehensile tail for grasping nesting materials as opposed to arboreal maneuvering. We relate the development of this adaptive behavior with ontogenetic changes in myosin heavy chain (MHC) isoform expression from 21 days to adulthood. Monodelphis domestica is expected to demonstrate a progressive ability to flex the distal tail up to age 7 months, when it should exhibit routine nest construction. We hypothesize that juvenile stages (3-7 months) will be characterized by retention of the neonatal isoform (MHC-Neo), along with predominant expression of fast MHC-2X and 2B, which will transition into greater MHC-1β and 2A isoform content as development progresses...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28516218/a-high-fat-diet-can-affect-bone-healing-in-growing-rats
#7
Jéssica Suzuki Yamanaka, Gabriela Rezende Yanagihara, Bruna Leonel Carlos, Júnia Ramos, Brígida Batista Brancaleon, Ana Paula Macedo, João Paulo Mardegan Issa, Antônio Carlos Shimano
A high-fat diet (HFD) can have a negative effect on bone quality in young and old people. Although bone healing in children is normally efficient, there is no evidence that children who have a diet rich in fat have compromised bone fracture regeneration compared with children with recommended dietary fat levels. The purpose of the present study was to evaluate the effects of an HFD on bone healing in growing female rats. Twenty-six postweaning female Wistar rats were divided into two groups (13 animals per group): a standard diet (SD) group and an HFD (with 60% of energy from fat) group...
May 17, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28515770/high-level-expression-of-recombinant-human-growth-hormone-in-escherichia-coli-crucial-role-of-translation-initiation-region
#8
Mahsa Ghavim, Khalil Abnous, Fatemeh Arasteh, Sahar Taghavi, Maryam Sadat Nabavinia, Mona Alibolandi, Mohammad Ramezani
For high-throughput production of recombinant protein in Escherichia coli (E. coli), besides important parameters such as efficient vector with strong promoter and compatible host, other important issues including codon usage, rare codons, and GC content specially at N-terminal region should be considered. In the current study, the effect of decreasing the percentage of GC nucleotides and optimizing codon usage at N-terminal region of human growth hormone (hGH) cDNA on the level of its expression in E. coli were investigated...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28513495/effect-of-post-crosslinking-haze-on-the-repeatability-of-scheimpflug-based-and-slit-scanning-imaging-devices
#9
Rohit Shetty, Aarti Agrawal, Rashmi Deshmukh, Luci Kaweri, Harsha L Rao, Harsha Nagaraja, Chaitra Jayadev
PURPOSE: The aim of this study was to analyze the effect of postcollagen crosslinking (CXL) haze on the measurement and repeatability of pachymetry and mean keratometry (Km) of four corneal topographers. MATERIALS AND METHODS: Sixty eyes of sixty patients with progressive keratoconus who had undergone accelerated CXL (ACXL) underwent imaging with a scanning slit imaging device (Orbscan II) and three Scheimpflug imaging devices (Pentacam HR, Sirius, and Galilei)...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28511512/evaluation-of-correlation-between-salivary-calcium-alkaline-phosphatase-and-osteoporosis-a-prospective-comparative-and-observational-study
#10
Mainak Kanti Saha, Prerna Agrawal, Suparna Ganguly Saha, Vinod Vishwanathan, Vandana Pathak, Sakuru Venkata Saiprasad, Purvi Dhariwal, Mahendra Dave
INTRODUCTION: Fixed and/or removable prosthodontics caters to the restorative needs of the largest count of geriatric patients whose rehabilitative procedures depend on the quality and quantity of available bone. The common diagnostic parameters for quantifying bone may involve an invasive blood examination, an expensive bone densitometry procedure or a urine analysis. Sialometry involving the basic biochemistry of saliva analysis may be proposed as an alternative to the conventional investigative protocol and its usefulness may be attributed owing to its non invasive and simpler procedure...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509822/fracture-prevention-in-the-orthopaedic-environment-outcomes-of-a-coordinator-based-fracture-liaison-service
#11
Earl R Bogoch, Victoria Elliot-Gibson, Dorcas Beaton, Joanna Sale, Robert G Josse
BACKGROUND: Fracture liaison services focus on secondary fracture prevention by identifying patients at risk for future fracture and initiating appropriate evaluation, risk assessment, education, and therapeutic intervention. This study describes key clinical outcomes including bone mineral densitometry, physician assessment, and pharmacotherapy initiation in pharmacotherapy-naïve patients undergoing treatment for fragility fracture in a Canadian fracture liaison service. METHODS: We determined rates of post-fracture investigation and treatment for inpatients and outpatients with a fragility fracture seen in a coordinator-based fracture liaison service at an urban university trauma hospital...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28501191/tlc-uv-hyphenated-with-maldi-tofms-for-the-screening-of-invertase-substrates-in-plant-extracts
#12
Justine Ferey, David Da Silva, Pierre Lafite, Richard Daniellou, Benoît Maunit
In this study, thin-layer chromatography (TLC) hyphenated with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) was developed for the screening of invertase substrates in complex matrices. BfrA, a specific β-D-fructofuranosidase from Leishmania major, was chosen as a model enzyme to screen biological activity in plant extracts due to its capacity to hydrolyze specific carbohydrates. TLC was considered to be a reliable technique for screening substrates (bioactive molecules) in plant extracts due to its quantitative capabilities whereas MALDI-TOFMS was particularly useful for rapid identification...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28486337/hypertrophic-effects-of-concentric-versus-eccentric-muscle-actions-a-systematic-review-and-meta-analysis
#13
Brad J Schoenfeld, Dan Ogborn, Andrew D Vigotsky, Martino Franchi, James W Krieger
Controversy exists as to whether different dynamic muscle actions produce divergent hypertrophic responses. The purpose of this paper was to conduct a systematic review and meta-analysis of randomized controlled trials comparing the hypertrophic effects of concentric versus eccentric training in healthy adults following regimented resistance training (RT). Studies were deemed eligible for inclusion if they met the following criteria: 1) were an experimental trial published in an English-language refereed journal; 2) directly compared concentric and eccentric actions without the use of external implements (i...
May 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28481807/maximum-arterial-contrast-concentrations-with-computed-tomography-and-left-ventriculography-implications-for-contrast-nephrotoxicity-risk
#14
Nicholas M Gutierrez, Jeffrey H Newhouse
PURPOSE: Contrast nephropathy occurs more frequently after cardiac angiography, which usually includes left ventriculography via direct left ventricular injection, than after contrast-enhanced computed tomography (CT), despite the usually higher intravenous contrast dose used for CT. To determine whether maximum renal arterial contrast concentration is higher after left ventriculography, we assessed this parameter for both procedures. MATERIALS AND METHODS: Contrast concentration in abdominal aortic blood during contrast-enhanced CT was measured by performing CT densitometry of aortic blood before contrast, and in the arterial phase, in 100 adults undergoing abdominal CT...
May 6, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28462788/effect-of-hand-positioning-on-dxa-total-and-regional-bone-and-body-composition-parameters-precision-error-and-least-significant-change
#15
Shane Thurlow, Brian Oldroyd, Karen Hind
Dual-energy X-ray absorptiometry (DXA) body composition measurements are performed in both clinical and research settings for estimations of total and regional fat mass, lean tissue mass, and bone mineral content. Subject positioning influences precision and positioning instructions vary between manufacturers. The aim of the study was to determine the effect of hand position and scan mode on regional and total body bone and body composition parameters and determine protocol-specific body composition precision errors...
April 25, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28461289/associations-in-asthma-between-quantitative-computed-tomography-and%C3%A2-bronchial-biopsy-derived-airway-remodelling
#16
Rachid Berair, Ruth Hartley, Vijay Mistry, Ajay Sheshadri, Sumit Gupta, Amisha Singapuri, Sherif Gonem, Richard P Marshall, Ana R Sousa, Aarti Shikotra, Richard Kay, Andrew Wardlaw, Peter Bradding, Salman Siddiqui, Mario Castro, Christopher E Brightling
Airway remodelling in asthma remains poorly understood. This study aimed to determine the association of airway remodelling measured on bronchial biopsies with 1) lung function impairment and 2) thoracic quantitative computed tomography (QCT)-derived morphometry and densitometry measures of proximal airway remodelling and air trapping.Subjects were recruited from a single centre. Bronchial biopsy remodelling features that were the strongest predictors of lung function impairment and QCT-derived proximal airway morphometry and air trapping markers were determined by stepwise multiple regression...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28449252/serum-phosphorus-levels-and-fracture-following-renal-transplantation
#17
Jasna Aleksova, Phillip Wong, William R Mulley, Kay Weng Choy, Robert McLachlan, Peter R Ebeling, Peter G Kerr, Frances Milat
PURPOSE: Increased fracture rates are observed in renal transplant recipients (RTRs) compared with the general population. Risk factors include age, diabetes, dialysis vintage, immunosuppression, and mineral and bone disorders(1). Low serum phosphorus levels occur post-transplantation; however its relationship with fracture risk has not been evaluated. The purpose of this study was to evaluate risk factors for fracture in RTRs at a single tertiary referral centre. METHODS: A retrospective cross-sectional analysis of 146 patients (75M, 71F) who had been referred for dual energy x-ray densitometry (DXA) post-renal transplantation was performed...
April 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28440652/an-experimental-and-theoretical-study-of-the-thermal-decomposition-of-c4h6-isomers
#18
James P A Lockhart, C Franklin Goldsmith, John B Randazzo, Branko Ruscic, Robert S Tranter
The chemistry of small unsaturated hydrocarbons, such as 1,3-butadiene (1,3-C4H6), 1,2-butadiene (1,2-C4H6), 2-butyne (2-C4H6), and 1-butyne (1-C4H6), is of central importance to the modeling of combustion systems. These species are important intermediates in combustion processes, and yet their high-temperature chemistry remains poorly understood, with various dissociation and isomerization pathways proposed in the literature. Here we investigate the thermal decompositions of 1,3-C4H6, 1,2-C4H6, 2-C4H6, and 1-C4H6 inside a diaphragmless shock tube, at postshock total pressures of 26-261 Torr and temperatures ranging from 1428 to 2354 K, using laser schlieren densitometry...
May 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28440509/modulation-of-mmp-2-and-9-secretion-by-cytokines-inducers-and-inhibitors-in-human-melanoma-a-2058-cells
#19
M Waheed Roomi, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath
Melanoma, an extremely aggressive cancer, causes the most skin cancer-related deaths, due to metastasis to other areas of the body, such as lymph nodes, lungs, liver, brain or bone. It is characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix and basement membrane, allowing cancer cells to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activities. We investigated the roles of these in regulation of MMP-2 and -9 in human melanoma A-2058 cells...
April 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28429193/effect-of-non-coherent-infrared-light-led-%C3%AE-945%C3%A2-%C3%A2-%C3%A2-20%C3%A2-nm-on-bone-repair-in-diabetic-rats-morphometric-and-spectral-analyses
#20
Alexandre Greca Diamantino, Renata Amadei Nicolau, Davidson Ribeiro Costa, Alessandra Paes de Barros Almeida, Danila Xênia de Miranda Mato, Marco Antonio de Oliveira, Ana Maria do Espírito Santo
Phototherapy using coherent light (lasers) and non-coherent light (light-emitting diodes (LEDs)) has been investigated for the purpose of biomodulation in biological tissues. Several effects can be expected, including pain moderation, biostimulation of cellular tropism, anti-inflammatory effects, regular circulatory stimulation, and tissue repair. The aim of this study was to evaluate the effect of LED (λ945 ± 20 nm, 48 mW) therapy on the regeneration process in femoral lesions of rats (Wistar). Seven irradiation sessions were held, with a 48-h interval between sessions...
April 20, 2017: Lasers in Medical Science
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