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https://www.readbyqxmd.com/read/28735723/a-rate-independent-continuum-model-for-bone-tissue-with-interaction-of-compressive-and-tensile-micro-damage
#1
Philippe K Zysset, Uwe Wolfram
Low bone strength is a major risk factor for osteoporotic fractures and is only partially determined by clinical densitometry. Accumulated micro-damage induces residual strains, degrades elastic modulus and reduces bone strength independently of bone mineral density. Histologically, overloading of bone in compression and tension leads to distinct crack size, distribution and orientation which interact during combined loading scenarios. Statistics of rheological models can describe this process and reproduce experimental stress-strain curves with an unprecedented realism, but are computationally expensive and therefore difficult to generalize to 3D...
July 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28732615/new-parameters-for-evaluating-corneal-biomechanics-and-intraocular-pressure-after-small-incision-lenticule-extraction-by%C3%A2-scheimpflug-based-dynamic-tonometry
#2
Joaquín Fernández, Manuel Rodríguez-Vallejo, Javier Martínez, Ana Tauste, Patrizia Salvestrini, David P Piñero
PURPOSE: To evaluate parameters and dynamic corneal densitometry with a new dynamic Scheimpflug analyzer (Corvis ST) in eyes having small-incision lenticule extraction (SMILE). SETTING: Qvision, Vithas Virgen del Mar Hospital, Almería, Spain. DESIGN: Retrospective case series. METHODS: The study comprised eyes from the same institution having small-incision lenticule extraction surgery. Preoperative and 1-month postoperative measurements were taken...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28730102/anti-scarring-effects-of-butaprost-on-human-subconjunctival-tenon-s-fibroblasts
#3
Jong Hoon Shin, Je Hyun Seo, Jae Ho Jung, Tae Woo Kim
AIM: To investigate the toxicity of the E-prostanoid 2 (EP2) receptor agonist, butaprost against human subconjunctival (Tenon's capsule) fibroblasts, and to determine the underlying mechanism. METHODS: We isolated Tenon's fibroblasts from the subconjunctival area of healthy subjects and evaluated the types of EP receptors expressed using quantitative real-time reverse transcription polymerase chain reaction (RT-PCR). The toxicity of butaprost against the fibroblasts was evaluated using methyl thiazolyl tetrazolium and lactic dehydrogenase assays...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28726652/investigation-of-bone-mineralization-in-patients-with-coronary-heart-disease-complicated-by-chronic-heart-failure-stage-ii-a
#4
I Krynytska, M Marushchak, T Zaets, I Savchenko, H Habor
The majority of the studies have shown that individuals with cardiovascular diseases have a higher risk of experiencing bone loss and thus greater predisposition to risk of fracture. On the other hand there is growing evidence that individuals with low bone mass have higher mortality for cardiovascular events compared to patients with cardiovascular disease with normal bone mass. This research aims to investigate bone mineralization in patients with coronary heart disease complicated by stage II-A chronic heart failure...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28723111/augmented-reality-for-real-time-detection-and-interpretation-of-colorimetric-signals-generated-by-paper-based-biosensors
#5
Steven M Russell, Antonio Doménech-Sánchez, Roberto de la Rica
Colorimetric tests are becoming increasingly popular in point-of-need analyses due to the possibility of detecting the signal with the naked eye, which eliminates the utilization of bulky and costly instruments only available in laboratories. However, colorimetric tests may be interpreted incorrectly by nonspecialists due to disparities in color perception or a lack of training. Here we solve this issue with a method that not only detects colorimetric signals but also interprets them so that the test outcome is understandable for anyone...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28719813/comparative-stability-indicating-chromatographic-methods-for-determination-of-4-hexylresorcinol-in-pharmaceutical-formulation-and-shrimps
#6
Rafeek F Shokry, Lories I Bebawy, Mohamed R Elghobashy, Samah S Abbas
Three chromatographic stability-indicating methods were developed for determination of 4-hexylresorcinol in pure form and in a pharmaceutical formulation. Method A was based on a gradient elution liquid chromatographic HPLC determination of 4-hexylresorcinol, its related impurities and in presence of its degradation products. UPLC-MS/MS (Method B) was described for determination of the cited drug in presence of its degradation products. Method C was a thin- layer chromatography (TLC)-densitometry method for the separation and determination of the active ingredient, one of its related impurities and in presence of its degradation products...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28716553/regional-analysis-of-age-related-local-bone-loss-in-the-spine-of-a-healthy-population-using-3d-voxel-based-modeling
#7
Alexander Valentinitsch, Stefano Trebeschi, Eva Alarcón, Thomas Baum, Johannes Kaesmacher, Claus Zimmer, Cristian Lorenz, Jan S Kirschke
Local variations in bone loss may be of great importance to individually predict osteoporotic fractures but are neglected by current densitometry techniques. The purpose of this study was to evaluate regional variations of normal bone loss at the spine among different age groups using voxel-based morphometry. Non-contrast MDCT scans of 16 patients under the age of 40 (mean age 26years) without spinal pathology were identified as a reference cohort, where each thoracolumbar vertebra was assessed individually...
July 14, 2017: Bone
https://www.readbyqxmd.com/read/28713511/accuracy-of-densitometry-of-two-cone-beam-computed-tomography-equipment-in-comparison-with-computed-tomography
#8
Sina Haghanifar, Sajad Yousefi, Ehsan Moudi, Farida Abesi, Ali Bijani, Ali Akbar Moghadamnia, Mehrdad Nabahati
BACKGROUND: The use of oral implants has been growing, and cone beam computerized tomography (CBCT) has become the method of choice for oral and maxillofacial radiology. OBJECTIVE: To assess the accuracy of bone densitometry in two different CBCT devices in comparison with MDCT (multi-detector CT). METHODS: Different concentrations of urografin, including 2.5%, 5%, 7.5%, 10%, 12.5%, were prepared, and the Hounsfield unit of these solution was measured by two CBCT devices (SORDEX CRANEX 3D and NEWTOM 5G) and one spiral CT device (SOMATOM SENSATION)...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28712984/quantitative-computed-tomography-current-status-and-new-developments
#9
Klaus Engelke
This review focuses on new developments and current controversies in the field of quantitative computed tomography. Recent positions of the International Society for Clinical Densitometry acknowledged the clinical value of quantitative computed tomography of the spine and the hip using clinical whole-body computed tomography (CT) scanners. Opportunistic screening summarizes a number of new approaches describing the dual use of clinical CT scans. For example, CT scans may have been taken for tumor diagnosis but may also be used for the prediction of high or low fracture risks as an additional benefit for the patient...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28711461/prevalence-of-comorbidities-in-rheumatoid-arthritis-and-evaluation-of-their-monitoring-in-clinical-practice-the-spanish-cohort-of-the-comora-study
#10
Alejandro Balsa, Leticia Lojo-Oliveira, Mercedes Alperi-López, María García-Manrique, Carmen Ordóñez-Cañizares, Lorena Pérez, Virginia Ruiz-Esquide, Alfonso Corrales, Javier Narváez, José Rey-Rey, Carlos Rodríguez-Lozano, Soledad Ojeda, Santiago Muñoz-Fernández, Joan M Nolla, José García-Torrón, Fernando Gamero, Rosario García-Vicuña, Blanca Hernández-Cruz, José Campos, José Rosas, José Francisco García-Llorente, Antonio Gómez-Centeno, Rafael Cáliz, Raimon Sanmartí, Alberto Bermúdez, Lydia Abasolo-Alcázar, Antonio Fernández-Nebro, Luis Rodríguez-Rodríguez, Carlos Marras, Miguel Ángel González-Gay, Ihsane Hmamouchi, Emilio Martín-Mola
OBJECTIVES: To describe the prevalence of comorbidities in patients with RA in Spain and discuss their management and implications using data from the Spanish cohort of the multinational study on COMOrbidities in Rheumatoid Arthritis (COMORA). METHODS: This is a national sub-analysis of the COMORA study. We studied the demographics and disease characteristics of 200 adults patients diagnosed with RA (1987 ACR), and routine practices for screening and preventing the following selected comorbidities: cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and depression...
July 12, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28708200/periacetabular-bone-densitometry-after-total-hip-arthroplasty-with-highly-porous-titanium-cups-a-2-year-follow-up-prospective-study
#11
Leo Massari, Alessandro Bistolfi, Pier Paolo Grillo, Alda Borré, Gaetano Gigliofiorito, Carlotta Pari, Andrea Francescotto, Piermario Tosco, Davide Deledda, Laura Ravera, Araldo Causero
INTRODUCTION: Trabecular Titanium is an advanced cellular solid structure, composed of regular multiplanar hexagonal interconnected cells that mimic the morphology of the trabecular bone. This biomaterial demonstrated improved mechanical properties and enhanced osteoinduction and osteoconduction in several in vitro and in vivo studies. The aim of this study was to assess Trabecular Titanium osseointegration by measuring periacetabular changes in bone mineral density (BMD) with dual-emission X-ray absorptiometry (DEXA)...
July 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28707673/increased-corneal-densitometry-as-a-subclinical-corneal-change-associated-with-multiple-myeloma
#12
C Busch, S Koh, Y Oie, M Ichii, Y Kanakura, K Nishida
No abstract text is available yet for this article.
July 14, 2017: Eye
https://www.readbyqxmd.com/read/28702661/clinically-approved-pegylated-nanoparticles-are-covered-by-a-protein-corona-that-boosts-the-uptake-by-cancer-cells
#13
M Papi, D Caputo, V Palmieri, R Coppola, S Palchetti, F Bugli, C Martini, L Digiacomo, D Pozzi, G Caracciolo
Today, liposomes are an advanced technology of drug carriers with a dozen drugs in clinical practice and many more in clinical trials. A bottleneck associated with the clinical translation of liposomes has long been 'opsonization', i.e. the adsorption of plasma proteins at the liposome surface resulting in their rapid clearance from circulation. For decades, the most popular way to avoid opsonization has been grafting polyethylene glycol (PEG) onto the liposome surface. Recent studies have clarified that grafting PEG onto the liposome surface reduces, but does not completely prevent protein binding...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28692232/-osteoporosis-in-menopausal-women-between-40-and-65-years-old-an-algorithm-for-the-gynaecologist
#14
Anna Surbone, Nicolas Vulliemoz, Elena Gonzalez-Rodriguez, Jean-Paul Chatelain, Olivier Lamy
Osteoporosis is a bone disease that promotes the development of fragility fractures. An algorithm is proposed for the gynaecologists'use to diagnose and treat osteoporosis in young menopausal women. The fracture risk can be calculated with the FRAX tool. If the 10-year fracture risk is ≥ 10 %, a bone densitometry is recommended, and the result is integrated in the FRAX tool. If the risk is between 10 and 20 %, a treatment should be discussed individually and, in some cases, a pharmacologic preventive treatment, by menopause hormonal treatment or SERMs, can be initiated...
October 26, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28689885/reduction-of-hydrogen-sulfide-synthesis-enzymes-cystathionine-%C3%AE-synthase-and-cystathionine-%C3%AE-lyase-in-the-colon-of-patients-with-hirschsprungs-s-disease
#15
Christian Tomuschat, Anne Marie O'Donnell, David Coyle, Prem Puri
PURPOSE: Hirschsprung's associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in Hirschsprung's Disease (HSCR). The pathogenesis of HAEC is poorly understood. In recent years, there is increasing evidence that a compromised intestinal barrier function plays a major role in the pathogenesis of HAEC. Hydrogen sulfide, synthesized from L-cysteine by two key enzymes, cystathionine-β-synthase (CBS) and cystathionine-γ-lysase (CSE) is reported to play a key role in regulating gastrointestinal motility and promoting resolution of inflammation...
June 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28689731/surgical-management-of-primary-hyperparathyroidism-a-single-center-experience
#16
David Kwan-Ru Huang, Fong-Fu Chou, Shun-Yu Chi, Yi-Chia Chan, Shun-Chen Huang
BACKGROUND: Primary hyperparathyroidism (PHPT) can occur at any age. This study aimed to compare the necessity, feasibility, safety, and outcomes of parathyroidectomy in the management of minor-symptomatic or asymptomatic PHPT patients according to age (young vs. old). METHODS: We retrospectively reviewed the medical records of 146 consecutive patients who underwent surgery for PHPT from January 2005 to June 2016 in our institution. The patients ranged in age from 12 to 85 years...
July 7, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28686515/tracing-dietary-mercury-histochemically-with-autometallography-through-the-liver-to-the-ovaries-and-spawned-eggs-of-the-temperate-coastal-marine-fish-spot-leiostomus-xanthurus
#17
John J Govoni, James A Morris, David W Evans
Exposure to mercury (Hg) results in reproductive abnormalities and deficiencies in female fish. We traced the maternal assimilation and redistribution of dietary inorganic (HgII) and organic (MeHg) Hg in a coastal marine fish, spot (Leiostomus xanthurus). We conducted a 90 d laboratory experiment in which treatment spot were fed muscle of blue marlin (Makaira nigricans) with elevated concentrations of mercury mixed with a commercial fish food, while control spot were fed only commercial food pellets. Gonadal maturation was induced by shortening photoperiod and increasing temperature...
July 7, 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28680704/small-incision-lenticule-extraction-for-correction-of-myopia-and-myopic-astigmatism-first-24-hour-outcomes
#18
Taixiang Liu, Tingting Dan, Yan Luo
PURPOSE: To observe the first 24-hour (h) outcomes of the small incision lenticule extraction procedure (SMILE) for myopia and myopic astigmatism. METHODS: Fifty-three eyes (27 patients) scheduled for SMILE were followed immediately (0 h), 2, 4, 6, and 24 h after SMILE. Uncorrected visual acuity (UCVA), conjunctival congestion, pain level, and corneal edema, thickness, and densitometry were recorded. RESULTS: At 2 h after SMILE, 15.1% of eyes had ≤0...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28668196/erratum-to-the-activity-of-a-spanish-bone-densitometry-unit-revisited-under-the-point-of-view-of-frax-reumatol-clin-8-2012-179-183
#19
Carmen Gómez-Vaquero, María Bianchi, Pilar Santo, Daniel Roig-Vilaseca, Javier Narváez, Joan M Nolla
No abstract text is available yet for this article.
July 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28662973/assessment-of-bone-mineral-density-at-the-distal-femur-and-the-proximal-tibia-by-dual-energy-x-ray-absorptiometry-in-individualswith-spinal-cord-injury-precision-of-protocol-and-relation-to-injury-duration
#20
Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K Boyd, W Brent Edwards
Spinal cord injury (SCI) is characterized by marked bone loss at the knee, and there is a need for established dual-energy X-ray absorptiometry (DXA) protocols to examine bone mineral density (BMD) at this location to track therapeutic progress and to monitor fracture risk. The purpose of this study was to quantify the precision and reliability of a DXA protocol for BMD assessment at the distal femur and the proximal tibia in individuals with SCI. The protocol was subsequently used to investigate the relationship between BMD and duration of SCI...
June 26, 2017: Journal of Clinical Densitometry
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