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https://www.readbyqxmd.com/read/29350509/measuring-overuse-with-electronic-health-records-data
#1
Thomas Isaac, Meredith B Rosenthal, Carrie H Colla, Nancy E Morden, Alexander J Mainor, Zhonghe Li, Kevin H Nguyen, Elizabeth A Kinsella, Thomas D Sequist
OBJECTIVES: To measure overuse of low-value care using electronic health record (EHR) data and manual chart review and to evaluate whether certain low-value services are better captured using EHR data. STUDY DESIGN: We implemented algorithms to extract performance on 13 Choosing Wisely-identified healthcare services using EHR data at a large physician practice group between 2011 and 2013. METHODS: We calculated rates of overuse using automated EHR extracts...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29345841/effects-of-high-impact-exercise-on-the-physical-properties-of-bones-of-ovariectomized-rats-fed-to-a-high-protein-diet
#2
Roberta Carminati Shimano, Gabriela Rezende Yanagihara, Ana Paula Macedo, Jessica Suzuki Yamanaka, Antônio Carlos Shimano, João Manuel R S Tavares, João Paulo Mardegan Issa
The aim of this study was to evaluate the effects of high-impact physical exercise as a prophylactic and therapeutic means in osteopenic bones of rats submitted to ovariectomy and protein diet intake. A total of 64 Wistar rats were divided into eight groups (n=8 each), being: OVX, ovx, standard diet and sedentary; OVXE, ovx, standard diet and jump; OVXP, ovx, high-protein diet and sedentary; and OVXEP, ovx, high-protein diet and jump; SH, sham, standard diet and sedentary; SHE, sham, standard diet and jump; SHP, sham, high-protein diet and sedentary; and SHEP, sham, high-protein-diet and jump...
January 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29344519/icg-clearance-test-and-99mtc-gsa-spect-ct-fusion-images
#3
REVIEW
Yuji Iimuro
Preoperative estimation of future remnant liver function is critical for major hepatic surgery to avoid postoperative morbidity and mortality. Among several liver function tests, the indocyanine green (ICG) clearance test is still the most popular dynamic method. The usefulness of ICG clearance test parameters, such as ICGR15, KICG, or PDRICG, has been reported by many investigators. The transcutaneous non-invasive pulse dye densitometry system has made the ICG clearance test more convenient and attractive, even in Western countries...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29336641/impact-of-forward-and-backward-scattering-and-corneal-higher-order-aberrations-on-visual-acuity-after-penetrating-keratoplasty
#4
Hidenaga Kobashi, Kazutaka Kamiya, Kimiya Shimizu
PURPOSE: To assess the relationship of forward and backward scattering and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) after penetrating keratoplasty (PK). METHODS: This retrospective study comprised 25 eyes of 25 consecutive patients who underwent PK using the VisuMax femtosecond laser system and age-matched 25 eyes of 25 healthy subjects. We quantitatively assessed objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics), corneal densitometry (CD) and corneal HOAs with the Scheimpflug rotating camera (Pentacam HR, Oculus) 1 year postoperatively...
January 16, 2018: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29335103/new-objective-lens-density-quantification-method-using-swept-source-optical-coherence-tomography-technology-comparison-with-existing-methods
#5
Christophe Panthier, Justine Burgos, Helene Rouger, Alain Saad, Damien Gatinel
PURPOSE: To assess a new objective cataract grading method based on lens densitometry on swept-source optical coherence tomography (SS-OCT) scans provided by the IOLMaster 700. SETTINGS: Rothschild Foundation, Paris, France. DESIGN: Prospective case series. METHODS: All patients consulting for cataract evaluation who provided their consent to participate in the study were included. A history of eye surgery, corneal or retinal disorders, and ocular dryness were exclusion criteria...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29330781/a-review-of-the-methods-and-associated-mathematical-models-used-in-the-measurement-of-fat-free-mass
#6
REVIEW
Jaydeep Sinha, Stephen B Duffull, Hesham S Al-Sallami
Fat-free mass (FFM) represents the lean component of the body devoid of fat. It has been shown to be a useful predictor of drug dose requirements, particularly in obesity where the excess fat mass does not contribute to drug clearance. However, measuring FFM involves complex and/or expensive experimental methodologies that preclude their use in routine clinical practice. Thus, models to predict FFM from readily measurable variables, such as body weight and height, have been developed and are used in both population pharmacokinetic modelling and clinical practice...
January 12, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29330062/fundus-densitometry-findings-suggest-optic-disc-hemorrhages-in-primary-open-angle-glaucoma-have-an-arterial-origin
#7
Jonathan C Chou, Clara C Cousins, John B Miller, Brian J Song, Lucy Q Shen, Michael A Kass, Janey L Wiggs, Louis R Pasquale
PURPOSE: To analyze optic disc hemorrhages (DH) associated with primary open-angle glaucoma by quantifying their geometric profile and comparing their densitometry with hemorrhages from retinal vein occlusions (RVO) and retinal macroaneurysms (MA), which have venous and arterial sources of bleeding, respectively. DESIGN: Retrospective cross-sectional study METHODS: Setting: Massachusetts Eye & Ear POPULATION: Fundus images of DH (n=40), MA (n=14), and RVO (n=25) were identified...
January 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29329765/usefulness-of-the-trabecular-bone-score-for-assessing-the-risk-of-osteoporotic-fracture
#8
L Redondo, E Puigoriol, J R Rodríguez, P Peris, E Kanterewicz
INTRODUCTION AND OBJECTIVES: The trabecular bone score (TBS) is an imaging technique that assesses the condition of the trabecular microarchitecture. Preliminary results suggest that TBS, along with the bone mineral density assessment, could improve the calculation of the osteoporotic fracture risk. The aim of this study was to analyse TBS values and their relationship with the clinical characteristics, bone mineral density and history of fractures of a cohort of posmenopausal women. MATERIAL AND METHODS: We analysed 2,257 posmenopausal women from the FRODOS cohort, which was created to determine the risk factors for osteoporotic fracture through a clinical survey and bone densitometry with vertebral morphometry...
January 9, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29322017/clinical-profile-and-long-term-follow-up-of-32-patients-with-postoperative-permanent-hypoparathyroidism
#9
Leyre Lorente-Poch, Juan J Sancho, Leticia Carballo, Antonio Sitges-Serra
Background: Parathyroid failure is the most common complication after total thyroidectomy but permanent impairment of the parathyroid function is unusual. Limited data is available assessing long-term follow-up, quality of life and complications occurring in patients with permanent hypoparathyroidism (PH). We aimed to assess the incidence of complications derived from PH status, their influence on the quality of life perceived by PH patients and its relation to standard medical treatment with calcium salts and active vitamin D analogues...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29319433/renal-damage-induced-by-the-pesticide-methyl-parathion-in-male-wistar-rats
#10
Victor Hugo Fuentes-Delgado, María Consolación Martínez-Saldaña, María Luisa Rodríguez-Vázquez, Miguel Arturo Reyes-Romero, José Luis Reyes-Sánchez, Fernando Jaramillo-Juárez
Little information is apparently available regarding the nephrotoxic effects induced by pesticides. The aim of this study was to examine the influence of low doses of methyl parathion (MP) on the structure and function of the kidney of male Wistar rats. A corn oil (vehicle) was administered to control rats, whereas treated rats received MP at 0.56 mg/kg orally (1/25 of LD50), every third day, for 8 weeks. At the end of each week following MP exposure, creatinine and glucose levels were measured in plasma, while glucose, inorganic phosphate, total proteins, albumin, and activity of γ-glutamyltranspeptidase (GGT) were determined in urine...
January 10, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29318794/osteosarcopenia-in-patients-with-hip-fracture-is-related-with-high-mortality
#11
Jun Il Yoo, Hyunho Kim, Yong Chan Ha, Hyuck Bin Kwon, Kyung Hoi Koo
BACKGROUND: This study evaluated the prevalence of osteosarcopenia, as well as the relationship between one-year mortality and osteosarcopenia, as defined by criteria of the Asian Working Group on Sarcopenia in patients age 60 or older with hip fracture. METHODS: A total of 324 patients age 60 years or older with hip fracture were enrolled in this retrospective observational study. The main outcome measure was the prevalence of osteosarcopenia, as well as the relationship between osteosarcopenia and 1-year mortality...
January 22, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29307094/diet-and-exercise-changes-following-bone-densitometry-in-the-patient-activation-after-dxa-result-notification-paadrn-study
#12
Douglas W Roblin, Peter Cram, Yiyue Lou, Stephanie W Edmonds, Sylvie F Hall, Michael P Jones, Kenneth G Saag, Nicole C Wright, Fredric D Wolinsky
Calcium and vitamin D intake and exercise are suboptimal among older adults. Following bone densitometry, a letter communicating individualized fracture risk accompanied by an educational brochure improved participants' lifestyle-but no more than existing communication strategies-over 52 weeks. Simple communication strategies are insufficient for achieving optimal levels of bone health behaviors. PURPOSE: The Patient Activation After DXA Result Notification (PAADRN) study was designed to evaluate whether a letter with individualized fracture risk and an educational brochure mailed to patients soon after their DXA might improve bone health behaviors (daily calcium intake, vitamin D supplementation, and weekly exercise sessions) compared to slower, less individualized communication characterizing usual care...
January 6, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29306499/an-alternative-treatment-for-osteoporotic-su-type-iii-periprosthetic-supracondylar-femur-fractures-double-locking-plate-fixation
#13
Hakan Çiçek, Ümit Tuhanioğlu, Hasan Ulaş Oğur, Fırat Seyfettinoğlu, Murat Bozkurt
INTRODUCTION: Patients with Su Type III fractures based on total knee arthroplasty (TKA) constitute a patient group with problematic treatment and management. Although it has difficulties, open reduction and internal fixation is one of the treatment options. METHOD: A retrospective evaluation was made of 22 patients surgically treated in our clinic with double locking, low contact titanium plate and screw for a Su Type III periprosthetic fracture based on TKA. The patients were evaluated with bone mineral densitometry, postoperative Knee Society Score (KSS), WOMAC and radiological evaluations...
January 3, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29305778/advanced-glycation-end-products-as-a-source-of-artifacts-in-immunoenzymatic-methods
#14
Aleksandra Kuzan, A Chwiłkowska, K Maksymowicz, A Szydełko-Bronowicka, K Stach, C Pezowicz, A Gamian
The most abundant proteins in the arteries are those of extracellular matrix, ie. collagen and elastin. Due to their long half-lifes these proteins have an increased chance to undergo glycation. The aim of this study was to determine relationship between the content of the main extracellular matrix proteins and the advanced glycation end products (AGEs) in arteries. In this study 103 fragments of aorta were analyzed by ELISA and immunobloting for the content of collagens type I, III and IV and elastin and the content of advanced glycation end-products (AGE)...
January 5, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29300261/scheimpflug-densitometry-after-dmek-versus-dsaek-two-year-outcomes
#15
Konstantinos Droutsas, Apostolos Lazaridis, Eleftherios Giallouros, Georgios Kymionis, Klio Chatzistefanou, Walter Sekundo
PURPOSE: To compare the course of Scheimpflug corneal densitometry (CD) after Descemet membrane endothelial keratoplasty (DMEK) versus Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: Fifty-four DMEK and 25 DSAEK cases without previous corneal surgery, complicated intraoperative or postoperative course, or vision-limiting ocular comorbidities were included. Pseudophakic eyes of age-matched subjects were recruited as controls (n = 20). Scheimpflug CD of the optically relevant zones (0-2 and 2-6 mm), best-corrected visual acuity (BCVA), endothelial cell density, and central corneal thickness were evaluated preoperatively and at 3, 6, 12, and 24 months postoperatively...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29285479/comparison-of-sub-bowman-keratoplasty-laser-in-situ-keratomileusis-flap-properties-between-microkeratome-and-femtosecond-laser
#16
Farhad Fazel, Mohammad Ghoreishi, Alireza Ashtari, Reza Arefpour, Mohammad Namgar
Background: Since thin and high-quality flaps produce more satisfactory surgical outcomes, flaps created by mechanical microkeratomes are more economical as compared with femtosecond lasers, and no Iranian study has concentrated laser in situ keratomileusis (LASIK) flap peculiarities between Moria Sub-Bowman keratoplasty (SBK) microkeratomes and LDV femtoseconds, the present study compares and contrasts them. Materials and Methods: This cross-sectional study was done on all patients who underwent LASIK surgery 1-month before this study...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29282548/the-qualyor-qualit%C3%A3-osseuse-lyon-orl%C3%A3-ans-study-a-new-cohort-for-non-invasive-evaluation-of-bone-quality-in-postmenopausal-osteoporosis-rationale-and-study-design
#17
Roland Chapurlat, Jean-Baptiste Pialat, Blandine Merle, Elisabeth Confavreux, Florence Duvert, Elisabeth Fontanges, Farida Khacef, Sylvie Loiseau Peres, Anne-Marie Schott, Eric Lespessailles
The diagnostic performance of densitometry is inadequate. New techniques of non-invasive evaluation of bone quality may improve fracture risk prediction. Testing the value of these techniques is the goal of the QUALYOR cohort. INTRODUCTION: The bone mineral density (BMD) of postmenopausal women who sustain osteoporotic fracture is generally above the World Health Organization definition for osteoporosis. Therefore, new approaches to improve the detection of women at high risk for fracture are warranted...
December 27, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29276732/normocalcemic-primary-hyperparathyroidism-associated-with-progressive-cortical-bone-loss-a-case-report
#18
Joseph R Tucci
The existence of normocalcemic primary hyperparathyroidism (NPHP) was acknowledged at the Third and Fourth International Proceedings on primary hyperparathyroidism PHPT but data relating to its clinical presentation, natural history, and skeletal status were limited and there was no information nor guidelines as to definitive therapy. Herein are reported biochemical, hormonal, and densitometry data in a postmenopausal woman seen initially for osteoporosis who was found to have increased serum PTH levels and normal serum total and ionized calcium levels without evidence of secondary hyperparathyroidism...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29261289/wavelength-dependent-damage-to-adenoviral-proteins-across-the-germicidal-uv-spectrum
#19
Sara E Beck, Natalie M Hull, Christopher Poepping, Karl G Linden
Adenovirus, a waterborne pathogen responsible for causing bronchitis, pneumonia, and gastrointestinal infections, is highly resistant to UV disinfection and therefore drives the virus disinfection regulations set by the U.S. Environmental Protection Agency. Polychromatic UV irradiation has been shown to be more effective at inactivating adenovirus and other viruses than traditional monochromatic irradiation emitted at 254 nm; the enhanced efficacy has been attributed to UV-induced damage to viral proteins. This research shows UV-induced damage to adenoviral proteins across the germicidal UV spectrum at wavelength intervals between 200 and 300 nm...
December 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29260289/abaloparatide-a-novel-pth-receptor-agonist-increased-bone-mass-and-strength-in-ovariectomized-cynomolgus-monkeys-by-increasing-bone-formation-without-increasing-bone-resorption
#20
N Doyle, A Varela, S Haile, R Guldberg, P J Kostenuik, M S Ominsky, S Y Smith, G Hattersley
Abaloparatide, a novel PTH1 receptor agonist, increased bone formation in osteopenic ovariectomized cynomolgus monkeys while increasing cortical and trabecular bone mass. Abaloparatide increased bone strength and maintained or enhanced bone mass-strength relationships, indicating preserved or improved bone quality. INTRODUCTION: Abaloparatide is a selective PTH1R activator that is approved for the treatment of postmenopausal osteoporosis. The effects of 16 months of abaloparatide administration on bone formation, resorption, density, and strength were assessed in adult ovariectomized (OVX) cynomolgus monkeys (cynos)...
December 19, 2017: Osteoporosis International
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