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https://www.readbyqxmd.com/read/27928628/calcium-41-a-technology-for-monitoring-changes-in-bone-mineral
#1
REVIEW
C M Weaver, B R Martin, G S Jackson, G P McCabe, M Peacock, M Wastney
The rare, long-lived radiotracer, (41)Ca, measured by accelerator mass spectrometry in the urine or serum following incorporation into the bone provides an ultra-sensitive tool to assess changes in bone calcium balance in response to an intervention. Changes in bone balance can be followed for years with one small dose that is both radiologically and biologically non-invasive. Sequential interventions can be compared, with greater precision than they can with biochemical markers of bone turnover and with greater power than with bone densitometry...
December 7, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27921146/bone-loss-at-the-distal-femur-and-proximal-tibia-in-persons-with-spinal-cord-injury-imaging-approaches-risk-of-fracture-and-potential-treatment-options
#2
REVIEW
C M Cirnigliaro, M J Myslinski, M F La Fountaine, S C Kirshblum, G F Forrest, W A Bauman
Persons with spinal cord injury (SCI) undergo immediate unloading of the skeleton and, as a result, have severe bone loss below the level of lesion associated with increased risk of long-bone fractures. The pattern of bone loss in individuals with SCI differs from other forms of secondary osteoporosis because the skeleton above the level of lesion remains unaffected, while marked bone loss occurs in the regions of neurological impairment. Striking demineralization of the trabecular epiphyses of the distal femur (supracondylar) and proximal tibia occurs, with the knee region being highly vulnerable to fracture because many accidents occur while sitting in a wheelchair, making the knee region the first point of contact to any applied force...
December 5, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27920814/low-energy-trauma-induced-intercondylar-femoral-fracture
#3
Mathias Aeby, Tobias Wyss, Birgit Mentrup, Erdmute Kunstmann, Franz Jakob, Daniel Aeberli
We present a 44-year-old female patient with recurrent fragility fractures including an intercondylar femoral fracture and with normal planar bone densitometry. Diagnosis of hypophosphatasia was suggested by low volumetric cortical bone mineral density and laboratory findings. DNA sequencing revealed heterozygous mutations in the exons 5, 6 and 9 of the ALPL gene, thus confirming the suspected diagnosis.
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27912968/validation-of-a-thin-layer-chromatography-densitometry-method-for-the-characterization-of-invertase-activity
#4
Justine Ferey, David Da Silva, Sophie Bravo-Veyrat, Pierre Lafite, Richard Daniellou, Benoît Maunit
This paper presents a kinetic study of invertase, a specific fructofuranosidase cloned from the Leishmania major genome. The kinetic parameters of the β-d-fructofuranosidase from Leishmania major (BfrA) were determined using Thin-Layer Chromatography (TLC) and UV-densitometry (TLC@UV) specifically developed for the separation and detection of three carbohydrates namely sucrose, glucose and fructose. Separation was performed on TLC silica gel 60 F254 plates impregnated with sodium bisulphate and citrate and heated prior to development...
November 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27910707/standard-hormone-therapy-is-inadequate-for-bone-density-in-premature-ovarian-insufficiency
#5
Helena Giraldo, Cristina Benetti-Pinto, Valeska Ferreira, Heraldo Garmes, Daniela Yela, Paulo Giraldo
To assess standard dose hormone therapy (HT) and bone mass in premature ovarian insufficiency (POI), 239 women with POI, 132 using standard estrogen dose HT and 107 women without HT, were evaluated. All underwent bone mineral density (BMD) evaluation in the lumbar spine (LS) and total femur (TF). Mean age, age at last period and body mass index (BMI) for the untreated and for the HT groups were 38.1 ± 6.1 and 36.8 ± 7.3 years; 31.4 ± 7.3 and 30.7 ± 7.2 years; 26.6 ± 7.1 and 25.8 ± 4...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27886084/intracranial-thrombus-morphology-and-composition-undergoes-time-dependent-changes-in-acute-ischemic-stroke-a-ct-densitometry-study
#6
Slaven Pikija, Jozef Magdic, Vladimir Trkulja, Peter Unterkreuter, Johannes Sebastian Mutzenbach, Helmut F Novak, Friedrich Weymayr, Larissa Hauer, Johann Sellner
The aim of our study was to assess whether cerebral artery clots undergo time-dependent morphological and compositional changes in acute ischemic stroke. We performed a retrospective chart review of patients admitted within 5 h from symptom onset to three European stroke centers and evaluated non-contrast-enhanced CT (NECT) for hyperdense artery signs (HAS) in 2565 scans. The occlusion site, density of HAS expressed in Hounsfield units (HU), area of HAS, and relative density (rHU) (HU clot/HU non-affected artery) were studied and related to time from symptom onset, clinical severity, stroke etiology, and laboratory parameters...
November 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27881164/administration-of-anti-receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-antibody-for-the-treatment-of-osteoporosis-was-associated-with-amelioration-of-hepatitis-in-a-female-patient-with-growth-hormone-deficiency-a-case-report
#7
Ayumu Takeno, Masahiro Yamamoto, Masakazu Notsu, Toshitsugu Sugimoto
BACKGROUND: Growth hormone deficiency (GHD) is associated with non-alcoholic fatty liver disease (NAFLD). A recent animal study showed that hepatocyte-specific receptor activator of nuclear factor-kappa B (RANK) knockout mice had significantly lower liver fat content compared with control mice concomitant with a decrease in production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) from hepatocytes and kupffer cells. The role of anti-RANK ligand (RANKL) antibody for osteoporosis on hepatitis in patients with aGHD is still unknown...
November 24, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27879179/-two-sisters-with-lung-emphysema
#8
I Piscaer, F M E Franssen, N H T Ten Hacken, E F M Wouters, R Janssen
BACKGROUND: α1-antitrypsin is an antiprotease that is mainly produced in the liver; it plays a crucial role in the protection of lung parenchyma against the destructive effects of proteases. Mutations in the α1-antitrypsin gene can cause α1-antitrypsin deficiency. Individuals homozygous for the Z-genotype have drastically lowered serum α1-antitrypsine concentrations and often develop lung emphysema at an early age. CASE DESCRIPTION: A 38-year-old woman and her 43-year-old sister both developed lung emphysema at an early age; this could be attributed to severe α1-antitrypsin deficiency...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27872411/osteoporosis-in-pediatric-liver-transplantation
#9
Walid Faraj, Ghina El Nounou, Abdallah Abou Al Naaj, Nancy Nakhoul, Ali Haydar, Mohammad Khalife
Liver transplantation provides an important, often life-saving treatment for end-stage liver disease. Osteoporosis post-liver transplantation has been described in adults; however, this has not been described in the pediatric population to date. We present a case of a 13-year-old female patient who underwent an orthotopic liver transplant for cryptogenic liver cirrhosis. Her immunosuppressants were tacrolimus and prednisone. Four months posttransplant, she started complaining of bilateral lower limb pain and limping while walking, progressing to a point where she was almost immobile...
December 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27870622/dual-energy-ct-for-the-musculoskeletal-system
#10
Paul I Mallinson, Tyler M Coupal, Patrick D McLaughlin, Savvas Nicolaou, Peter L Munk, Hugue A Ouellette
The principal advantages of dual-energy computed tomography (CT) over conventional CT in the musculoskeletal setting relate to the additional information provided regarding tissue composition, artifact reduction, and image optimization. This article discusses the manifestations of these in clinical practice-urate and bone marrow edema detection, metal artifact reduction, and tendon analysis, with potential in arthrography, bone densitometry, and metastases surveillance. The basic principles of dual-energy CT physics and scanner design will also be discussed...
December 2016: Radiology
https://www.readbyqxmd.com/read/27866217/osteonecrosis-of-the-jaw-onj-and-atypical-femoral-fracture-aff-in-an-osteoporotic-patient-chronically-treated-with-bisphosphonates
#11
A Sánchez, R Blanco
The aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87 years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999-2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006-2008). She received occasional supplements of ergocalciferol...
November 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27859736/relationship-between-a163g-osteoprotegerin-gene-polymorphism-and-other-osteoporosis-parameters-in-roma-and-non-roma-postmenopausal-women-in-eastern-slovakia
#12
Marta Mydlárová Blaščáková, Ľudmila Blaščáková, Janka Poráčová, Jozef Mydlár, Janka Vašková, Jarmila Bernasovská, Iveta Boroňová, Eva Petrejčíková, Ivan Bernasovský
BACKGROUND: The study was focused on evaluating the possible correlation between biochemical, anthropometric, and genetic indicators of osteoporosis in postmenopausal women. The frequency of genotypes and differences in measured parameters were evaluated within two ethnically different groups of women in Slovakia. METHODS: The study included 310 postmenopausal women divided into non-Roma and Roma groups. Based on results of densitometry, they were divided into control groups and women with osteoporosis and osteopenia...
November 15, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27852598/frailty-and-bone-health-in-european-men
#13
Michael J Cook, Alexander Oldroyd, Stephen R Pye, Kate A Ward, Evelien Gielen, Rathi Ravindrarajah, Judith E Adams, David M Lee, Gyorgy Bartfai, Steven Boonen, Felipe Casanueva, Gianni Forti, Aleksander Giwercman, Thang S Han, Ilpo T Huhtaniemi, Krzysztof Kula, Michael E Lean, Neil Pendleton, Margus Punab, Dirk Vanderschueren, Frederick C Wu, Terence W O'Neill
BACKGROUND: frailty is associated with an increased risk of fragility fractures. Less is known, however, about the association between frailty and bone health. METHODS: men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study. Subjects completed a comprehensive assessment which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA)...
November 16, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27847194/small-hdl-subclasses-become-cholesterol-poor-during-postprandial-period-after-a-fat-diet-intake-in-subjects-with-high-triglyceridemia-increases
#14
Armando Quintanilla-Cantú, Paola Peña-de-la-Sancha, Cristobal Flores-Castillo, Ana María Mejía-Domínguez, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Rocío Bautista-Pérez, Reyna Esmeralda Enriquez-Calderón, Marco Antonio Juárez-Oropeza, José Manuel Fragoso, Gilberto Vargas-Alarcón, Oscar Pérez-Méndez
BACKGROUND: Postprandial triglyceridemia may transitory affect the structure of HDL subclasses and probably their antiatherogenic properties but little is known in this field. We analyzed the HDL subclasses lipid content along postprandial period. METHODS: Fifteen metabolic syndrome (MS) patients and 15 healthy controls were enrolled. HDL were isolated from plasma samples obtained at fasting and every 2-h up to 8-h, after a 75-g fat meal. Cholesterol (C), triglycerides (TAG), and phospholipid (Ph) plasma concentrations of five HDL subclasses were determined by densitometry of electrophoresis gels enzymatically stained...
November 12, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27843230/preclinical-cataract-masquerading-as-post-lasik-regression
#15
Rohit Shetty, Nikhil Negalur, Mathew Kurian, Rushad Shroff
The purpose of this case report is to bring forth a rare clinical scenario where preclinical cataract mimics post-LASIK regression and to describe the role of aberrometry in detecting higher order aberrations (HOAs) and early lens changes. A 36-year-old female presented with blurring of vision since 1 year after having undergone an uneventful LASIK surgery 3 years prior. Corneal topography and aberrometry were within normal limits. Although the lens was morphologically normal on slit lamp examination, increased HOAs and lenticular density were detected...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27837355/corneal-densitometry-and-its-correlation-with-age-pachymetry-corneal-curvature-and-refraction
#16
Nuria Garzón, Francisco Poyales, Igor Illarramendi, Javier Mendicute, Óscar Jáñez, Pedro Caro, Alfredo López, Francisco Argüeso
PURPOSE: To determine normative corneal densitometry values in relation to age, sex, refractive error, corneal thickness, and keratometry, measured using the Oculus Pentacam system. METHODS: Three hundred and thirty-eight healthy subjects (185 men; 153 women) with no corneal disease underwent an exhaustive ocular examination. Corneal densitometry was expressed in standardized grayscale units (GSU). RESULTS: The mean corneal densitometry over the total area was 16...
November 11, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27836529/twelve-years-of-experience-with-miglustat-in-the-treatment-of-type-1-gaucher-disease-the-spanish-zagal-project
#17
Pilar Giraldo, Marcio Andrade-Campos, Pilar Alfonso, Pilar Irun, Koldo Atutxa, Antonio Acedo, Abelardo Barez, Margarita Blanes, Vicente Diaz-Morant, Ma Angeles Fernández-Galán, Rafael Franco, Cristina Gil-Cortes, Vicente Giner, Angela Ibañez, Paz Latre, Ines Loyola, Elisa Luño, Roberto Hernández-Martin, Blanca Medrano-Engay, José Puerta, Inmaculada Roig, Javier de la Serna, Olga Salamero, Lucia Villalón, Miguel Pocovi
We report data from a prospective, observational study (ZAGAL) evaluating miglustat 100mg three times daily orally. in treatment-naïve patients and patients with type 1 Gaucher Disease (GD1) switched from previous enzyme replacement therapy (ERT). Clinical evolution, changes in organ size, blood counts, disease biomarkers, bone marrow infiltration (S-MRI), bone mineral density by broadband ultrasound densitometry (BMD), safety and tolerability annual reports were analysed. Between May 2004 and April 2016, 63 patients received miglustat therapy; 20 (32%) untreated and 43 (68%) switched...
October 24, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27825681/a-novel-hybrid-sensor-for-combined-imaging-of-dissolved-oxygen-and-labile-phosphorus-flux-in-sediment-and-water
#18
Chao Han, Jinghua Ren, Zhaode Wang, Hao Tang, Di Xu
A novel sensor assembled by a hybrid film was developed for 2D combined measurements of DO dynamic and labile P flux in sediment and water at sub-millimeter resolution based on PO and DGT techniques. The hybrid film is comprised of a transparent polyester membrane supporting two ultrathin sensing layers, i.e., a P binding layer (PBL) overlying a DO sensing layer (DSL). A robust, straightforward measuring strategy based on the referenced RGB and coloration-computer imaging densitometry (CID) methods was developed...
January 1, 2017: Water Research
https://www.readbyqxmd.com/read/27825046/talin-a-potential-protein-biomarker-in-postmortem-investigations
#19
Zahra K Campell, Insu Kwon, Sheree J Finley, Youngil Lee, Gulnaz T Javan
The determination of the postmortem interval is of utmost importance in medicolegal death investigations. There are a number of ways to estimate the postmortem interval; however, the current established methods are susceptible to numerous biotic and abiotic factors. Previously published studies state that protein concentrations in postmortem brain tissues can detect protein changes via immunoblotting and densitometry techniques. The objective of the current study was to determine if there is a correlation between protein expression in cadaver tissues and postmortem interval...
November 2016: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/27824385/corneal-scheimpflug-densitometry-following-photorefractive-keratectomy-in-myopic-eyes
#20
Marie Boulze-Pankert, Romuald Dariel, Louis Hoffart
PURPOSE: To evaluate the modification of corneal optical densitometry following photorefractive keratectomy (PRK) using Scheimpflug topography. METHODS: Corneal densitometry (0 to 100 grayscale units [GSU]), pachymetry, and keratometry were evaluated using a rotating Scheimpflug camera (Pentacam HR; Oculus Optikgeräte, GmbH, Wetzlar, Germany) at baseline and 1 and 3 months following PRK in myopic patients. Subjective refraction, uncorrected distance visual acuity, corrected distance visual acuity, and corneal haze (0 to 4 on common subjective scale) were evaluated preoperatively at baseline, 1 month, and 3 months...
November 1, 2016: Journal of Refractive Surgery
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