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https://www.readbyqxmd.com/read/29471454/the-impact-of-using-different-reference-populations-on-measurement-of-breast-cancer-related-cognitive-impairment-rates
#1
Jonathan D Clapp, George Luta, Brent J Small, Tim A Ahles, James C Root, Deena Graham, Arti Hurria, Paul B Jacobsen, Heather Jim, Brenna C McDonald, Robert A Stern, Andrew J Saykin, Jeanne S Mandelblatt
Objective: To evaluate how use of different reference populations affects estimates of breast cancer-related cognitive impairment rates. Methods: Patients aged ≥60 years with stage 0-3 breast cancer (n = 371) and matched non-cancer controls (n = 370) completed 13 neuropsychological tests prior to systemic therapy or at enrollment (controls). The tests captured three domains: attention, processing speed and executive function; learning and memory; and visual-spatial function...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29468297/aldopentoses-as-new-substrates-for-the-membrane-bound-pyrroloquinoline-quinone-dependent-glycerol-polyol-dehydrogenase-of-gluconobacter-sp
#2
Toshiharu Yakushi, Yuka Terada, Seishiro Ozaki, Naoya Kataoka, Yoshihiko Akakabe, Osao Adachi, Minenosuke Matsutani, Kazunobu Matsushita
Membrane-bound, pyrroloquinoline quinone (PQQ)-dependent glycerol dehydrogenase (GLDH, or polyol dehydrogenase) of Gluconobacter sp. oxidizes various secondary alcohols to produce the corresponding ketones, such as oxidation of D-sorbitol to L-sorbose in vitamin C production. Substrate specificity of GLDH is considered limited to secondary alcohols in the D-erythro configuration at the next to the last carbon. Here, we suggest that L-ribose, D- and L-lyxoses, and L-tagatose are also substrates of GLDH, but these sugars do not meet the substrate specificity rule of GLDH...
February 21, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29466418/evaluation-of-the-biocontrol-efficacy-of-a-serratia-marcescens-strain-indigenous-to-tea-rhizosphere-for-the-management-of-root-rot-disease-in-tea
#3
Gargee Dhar Purkayastha, Preeti Mangar, Aniruddha Saha, Dipanwita Saha
The aim of the present study is to evaluate plant growth promoting and biocontrol efficacy of a Serratia marcescens strain ETR17 isolated from tea rhizosphere for the effective management of root rot disease in tea. Isolated bacterial culture ETR17 showed significant level of in vitro antagonism against nine different foliar and root pathogens of tea. The phenotypic and molecular characterization of ETR17 revealed the identity of the bacterium as Serratia marcescens. The bacterium was found to produce several hydrolytic enzymes like chitinase, protease, lipase, cellulase and plant growth promoting metabolites like IAA and siderophore...
2018: PloS One
https://www.readbyqxmd.com/read/29464510/determination-of-e-ferulic-acid-content-in-the-root-of-angelica-acutiloba-a-simple-chemical-evaluation-method-for-crude-drug-quality-control
#4
Noriko Shinjyo, Hiroyuki Fuchino, Nobuo Kawahara, Atsuyuki Hishida
The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharmacopoeia. (E)-ferulic acid (FA) is an important active ingredient of Angelica spp., including A. sinensis (Oliv.) Diels, and has been suggested as a marker for quality evaluation of those crude drugs...
February 20, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29462787/mechanistic-insights-into-transferable-polymyxin-resistance-among-gut-bacteria
#5
Yongchang Xu, Jingxia Lin, Tao Cui, Swaminath Srinivas, Youjun Feng
Polymyxins such as colistin are antibiotics used as a final line of defense in the management of infections with multidrug-resistant Gram-negative bacteria. Although natural resistance to polymyxins is rare, the discovery of a mobilized colistin resistance gene ( mcr-1 ) in gut bacteria has raised significant concern. As an intramembrane enzyme, MCR-1 catalyzes the transfer of phosphoethanolamine (PEA) to the 1 (or 4')-phosphate group of the lipid A moiety of lipopolysaccharide (LPS), thereby conferring colistin resistance...
February 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29459040/interocular-axial-length-and-corneal-power-differences-as-predictors-of-postoperative-refractive-outcomes-after-cataract-surgery
#6
Vinay Kansal, Matthew Schlenker, Iqbal Ike K Ahmed
PURPOSE: To determine whether differences between eyes in axial length (AL) and corneal power (K) on optical biometry are predictive of refractive outcomes. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 729 patients (1458 eyes) who underwent bilateral phacoemulsification at TLC (Mississauga, Ontario, Canada) from September 2013 to August 2015. METHODS: We compared the proportion of patients having >0...
February 16, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29458372/relationship-of-ct-quantified-emphysema-small-airways-disease-and-bronchial-wall-dimensions-with-physiological-inflammatory-and-infective-measures-in-copd
#7
Kristoffer Ostridge, Nicholas P Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Stuart C Clarke, Emmanuel Aris, Sonia Mesia-Vela, Jeanne-Marie Devaster, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J Staples, Tom M A Wilkinson
BACKGROUND: COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical outcome, so other tools are required to investigate the disease. We sought to explore the relationships between quantitative CT analysis with functional, inflammatory and infective assessments of disease to identify the utility of imaging to stratify disease to better predict outcomes and disease response...
February 20, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29457957/synergistic-effect-of-entomopathogenic-fungus-fusarium-oxysporum-extract-in-combination-with-temephos-against-three-major-mosquito-vectors
#8
Perumal Vivekanandhan, Sengodan Karthi, Muthugounder S Shivakumar, Giovanni Benelli
Mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. Improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. Herein, we evaluated the toxicity of Fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of Anopheles stephensi, Aedes aegypti and Culex quinquefaciatus. F. oxysporum extract was characterized using TLC, FT-IR and GC-MS...
February 19, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29457316/assessment-of-pulmonary-structure-function-relationships-in-young-children-and-adolescents-with-cystic-fibrosis-by-multivolume-proton-mri-and-ct
#9
Francesca Pennati, David J Roach, John P Clancy, Alan S Brody, Robert J Fleck, Andrea Aliverti, Jason C Woods
BACKGROUND: Lung disease is the most frequent cause of morbidity and mortality in patients with cystic fibrosis (CF), and there is a shortage of sensitive biomarkers able to regionally monitor disease progression and to assess early responses to therapy. PURPOSE: To determine the feasibility of noncontrast-enhanced multivolume MRI, which assesses intensity changes between expiratory and inspiratory breath-hold images, to detect and quantify regional ventilation abnormalities in CF lung disease, with a focus on the structure-function relationship...
February 19, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29438772/lumen-area-change-delta-lumen-between-inspiratory-and-expiratory-ct-as-a-measure-of-severe-outcomes-in-asthma
#10
Sung Shine Shim, Mark L Schiebler, Michael D Evans, Nizar Jarjour, Ron L Sorkness, Loren Denlinger, Alfonso Rodriguez, Sally Wenzel, Eric A Hoffman, Ching-Long Lin, David S Gierada, Mario Castro, Sean B Fain
BACKGROUND: Quantitative computed tomography (QCT) biomarkers of airway morphology hold potential for understanding and monitoring regional airway remodeling in asthma. OBJECTIVE: We sought to determine if the change of airway lumen area between TLC and FRC lung volumes measured from CT imaging data was correlated with severe outcomes in asthma patients. METHODS: We studied 152 asthma patients (90 female and 62 male) and 33 normal subjects (12 female and 21 male) with QCT...
February 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29435329/use-of-diaphragm-thickening-fraction-combined-with-rapid-shallow-breathing-index-for-predicting-success-of-weaning-from-mechanical-ventilator-in-medical-patients
#11
Pattarin Pirompanich, Sasithon Romsaiyut
Background: Weaning failure is a crucial hindrance in critically ill patients. Rapid shallow breathing index (RSBI), a well-known weaning index, has some limitations in predicting weaning outcomes. A new weaning index using point-of-care ultrasound with diaphragmic thickening fraction (DTF) has potential benefits for improving weaning success. The aim of this study was to evaluate the efficacy of a combination of DTF and RSBI for predicting successful weaning compared to RSBI alone. Methods: This prospective study enrolled patients from the medical intensive care unit or ward who were using mechanical ventilation and readied for weaning...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29433082/acute-exposure-to-chlorpyrifos-induces-reversible-changes-in-health-parameters-of-nile-tilapia-oreochromis-niloticus
#12
Eman Zahran, Engy Risha, Walaa Awadin, Dušan Palić
Chlorpyrifos (CPF) is one of the most common insecticides found in freshwater ecosystems, and has been detected in agricultural and fishery products worldwide. This study focused on comprehensive panel of hematological, immunotoxic and pathology changes in Nile tilapia (Oreochromis niloticus) during and after exposure to CPF at 15 μg/L (0.043 μM) (1/10 LC50, group CPF1), or 75 μg/L (0.21 μM) (1/2 LC50, group CPF2) for 14 days, followed by 2 weeks recovery. Different endpoints were used to determine effects of CPF on fish health: hematological parameters; antioxidant levels in liver and gills; innate immune parameters; expression levels of pro-inflammatory cytokine genes at mRNA level in anterior kidney and spleen; and histopathological assessment of gills, liver, and kidney tissues...
February 6, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29432823/mechanism-based-pharmacokinetic-mbpk-models-describe-the-complex-plasma-kinetics-of-three-antiretrovirals-delivered-by-a-long-acting-anti-hiv-drug-combination-nanoparticle-formulation
#13
John C Kraft, Lisa A McConnachie, Josefin Koehn, Loren Kinman, Jianguo Sun, Ann C Collier, Carol Collins, Danny D Shen, Rodney J Y Ho
Existing oral antiretroviral (ARV) agents have been shown in human studies to exhibit limited lymph node penetration and lymphatic drug insufficiency. As lymph nodes are a reservoir of HIV, it is critical to deliver and sustain effective levels of ARV combinations in these tissues. To overcome lymph node drug insufficiency of oral combination ARV therapy (cART), we developed and reported a long-acting and lymphocyte-targeting injectable that contains three ARVs-hydrophobic lopinavir (LPV) and ritonavir (RTV), and hydrophilic tenofovir (TFV)-stabilized by lipid excipients in a nanosuspension...
February 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29429028/molecules-of-damage-associated-patterns-in-bronchoalveolar-lavage-fluid-and-serum-in-chronic-obstructive-pulmonary-disease
#14
Beata Brajer-Luftmann, Agata Nowicka, Mariusz Kaczmarek, Magdalena Wyrzykiewicz, Senan Yasar, Tomasz Piorunek, Marcin Grabicki, Magdalena Kostrzewska, Jan Sikora, Halina Batura-Gabryel
Chronic exposure to detrimental environmental factors may induce immunogenic cell death of structural airway cells in chronic obstructive pulmonary disease (COPD). Damage-associated molecular patterns (DAMPs) is a family of heterogeneous molecules released from injured or dead cells, which activate innate and adaptive immune responses on binding to the pattern recognition receptors on cells. This study seeks to define the content of DAMPs in the bronchoalveolar lavage fluid (BALF) and serum of COPD patients, and the possible association of these molecules with clinical disease features...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29425266/lipophilicity-of-new-anticancer-1-6-and-3-6-diazaphenothiazines-by-of-use-rp-tlc-and-different-computational-methods
#15
Beata Morak-Mlodawska, Krystian Pluta, Malgorzata Jelen
The lipophilicity of new two series of anticancer active 10-substituted 1,6- and 3,6-diazaphenothiazines has been investigated using reversed-phase thin-layer chromatography. Their lipophilicity (RM0 and log PTLC) was determined with mixtures of acetone and Tris buffer as mobile phases. The relative lipophilicity parameter RM0 and specific hydrophobic surface area b were significantly intercorrelated showing congeneric classes of diazaphenothiazines. The parameter RM0 was transformed into parameter log PTLC by use of the calibration curve...
February 7, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29424195/clinical-features-and-prognostic-significance-of-splenic-involvement-in-sarcoidosis
#16
Cuneyt Tetikkurt, Halil Yanardag, Metin Pehlivan, Muammer Bilir
Sarcoidosis is a systemic disease characterized by noncasefied granulomas in various organs. Incidence of splenic disease is variable and is reported to occur in 6.7 to 77 percent of the patients. Firm data establishing the clinical features and the association of splenic involvement with prognosis in sarcoidosis is scant. The aim of our study was to investigate the clinical features and the consequence of splenic involvement on the prognostic outcome of sarcoidosis patients. We evaluated the clinical and laboratory findings in 82 sarcoidosis patients...
December 21, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29421696/purification-and-characterization-of-%C3%AE-galactosidase-from-probiotic-pediococcus-acidilactici-and-its-use-in-milk-lactose-hydrolysis-and-galactooligosaccharide-synthesis
#17
Preeti Chanalia, Dimpi Gandhi, Pooja Attri, Suman Dhanda
β-galactosidase is a commercially important enzyme that was purified from probiotic Pediococcus acidilactici. The enzyme was extracted from cells using sonication and subsequently purified using ammonium sulphate fractionation and successive chromatographies on Sephadex G-100 and Q-Sepharose. The enzyme was purified 3.06-fold up to electrophoretic homogeneity with specific activity of 0.883 U/mg and yield of 28.26%. Molecular mass of β-galactosidase as estimated by SDS-PAGE and MALDI-TOF was 39.07 kDa. The enzyme is a heterodimer with subunit mass of 15...
January 4, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29417845/acanthus-mollis-l-leaves-as-source-of-anti-inflammatory-and-antioxidant-phytoconstituents
#18
Patrícia Matos, Artur Figueirinha, Isabel Ferreira, Maria Teresa Cruz, Maria Teresa Batista
This work expands the phytochemical composition knowledge of Acanthus mollis and evaluates antioxidant and anti-inflammatory activities which could be related with its traditional uses. Extracts from leaves, obtained by sequential extraction, were screened using TLC and HPLC-PDA. The ethanol extract was the most active on DPPH assay (IC50 = 20.50 μg/mL) and inhibited nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 48.31 μg/mL). Significant amounts of cyclic hydroxamic and phenolic acids derivatives were detected...
February 8, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29417078/efficacy-of-intense-pulsed-light-therapy-with-topical-benzoyl-peroxide-5-versus-benzoyl-peroxide-5-alone-in-mild-to-moderate-acne-vulgaris-a-randomized-controlled-trial
#19
Fatemeh Mokhtari, Maryam Gholami, Amir Hossein Siadat, Tohid Jafari-Koshki, Gita Faghihi, Mohammad Ali Nilforoushzadeh, Sayed Mohsen Hosseini, Bahareh Abtahi-Naeini
Objective: Acne vulgaris is a disease of pilosebaceous unit with multifactorial pathogenesis and threats patients' social functioning. There is a growing research to find faster, more effective, and easy to use treatments. The aim of this study is to evaluate the efficacy of benzoyl peroxide 5% (BP) with and without concomitant intense-pulsed light (IPL) therapy in mild-to-moderate acne vulgaris. Methods: In this controlled trial, 58 eligible patients with mild-to-moderate acne and Fitzpatrick skin phototype III and IV were randomly allocated to two groups...
October 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29409746/in-vitro-and-in-silico-attenuation-of-quorum-sensing-mediated-pathogenicity-in-pseudomonas-aeruginosa-using-spirulina-platensis
#20
Felix LewisOscar, Chari Nithya, Sulaiman Ali Alharbi, Naiyf S Alharbi, Nooruddin Thajuddin
Biofilm forming pathogenic bacteria showing resistance towards antimicrobial agents has increased the urge to find an alternative treatment strategy. Among the biofilm forming pathogenic bacteria, Pseudomonas aeruginosa is a well-recognised Gram negative biofilm former causing nosocomial infection and other disease among immunocompromised patients. The aim of the current study is to evaluate the antipathogenic potentials of S. platensis against P. aeruginosa. S. platensis methanolic extract (SME) inhibited the biofilm (89%), extracellular polymeric substances (EPS), cell surface hydrophobicity (CSH) (44%), pyocyanin, pyoveridin and swarming motility of P...
January 31, 2018: Microbial Pathogenesis
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