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https://www.readbyqxmd.com/read/29351296/hybrid-genome-assembly-and-annotation-of-paenibacillus-pasadenensis-strain-r16-reveals-insights-on-endophytic-life-style-and-antifungal-activity
#1
Alessandro Passera, Luca Marcolungo, Paola Casati, Milena Brasca, Fabio Quaglino, Chiara Cantaloni, Massimo Delledonne
Bacteria of the Paenibacillus genus are becoming important in many fields of science, including agriculture, for their positive effects on the health of plants. However, there are little information available on this genus compared to other bacteria (such as Bacillus or Pseudomonas), especially when considering genomic information. Sequencing the genomes of plant-beneficial bacteria is a crucial step to identify the genetic elements underlying the adaptation to life inside a plant host and, in particular, which of these features determine the differences between a helpful microorganism and a pathogenic one...
2018: PloS One
https://www.readbyqxmd.com/read/29350407/recent-progress-in-the-antiviral-activity-and-mechanism-study-of-pentacyclic-triterpenoids-and-their-derivatives
#2
REVIEW
Sulong Xiao, Zhenyu Tian, Yufei Wang, Longlong Si, Lihe Zhang, Demin Zhou
Viral infections cause many serious human diseases with high mortality rates. New drug-resistant strains are continually emerging due to the high viral mutation rate, which makes it necessary to develop new antiviral agents. Compounds of plant origin are particularly interesting. The pentacyclic triterpenoids (PTs) are a diverse class of natural products from plants composed of three terpene units. They exhibit antitumor, anti-inflammatory, and antiviral activities. Oleanolic, betulinic, and ursolic acids are representative PTs widely present in nature with a broad antiviral spectrum...
January 19, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29349039/engineering-escherichia-coli-for-the-production-of-terpene-mixture-enriched-in-caryophyllene-and-caryophyllene-alcohol-as-potential-aviation-fuel-compounds
#3
Weihua Wu, Fang Liu, Ryan W Davis
Recent studies have revealed that caryophyllene and its stereoisomers not only exhibit multiple biological activities but also have desired properties as renewable candidates for ground transportation and jet fuel applications. This study presents the first significant production of caryophyllene and caryolan-1-ol by an engineered E. coli with heterologous expression of mevalonate pathway genes with a caryophyllene synthase and a caryolan-1-ol synthase. By optimizing metabolic flux and fermentation parameters, the engineered strains yielded 449 mg/L of total terpene, including 406 mg/L sesquiterpene with 100 mg/L caryophyllene and 10 mg/L caryolan-1-ol...
June 2018: Metabolic Engineering Communications
https://www.readbyqxmd.com/read/29342972/the-effect-of-combining-natural-terpenes-and-antituberculous-agents-against-reference-and-clinical-mycobacterium-tuberculosis-strains
#4
Elwira Sieniawska, Rafal Sawicki, Marta Swatko-Ossor, Agnieszka Napiorkowska, Agata Przekora, Grazyna Ginalska, Ewa Augustynowicz-Kopec
Background: On account of emergence of multi- and extensively drug-resistant Mycobacterium tuberculosis (Mtb) strains, combinations of drugs with natural compounds were tested to search for antibiotic activity enhancers. In this work we studied terpenes (α-pinene, bisabolol, β-elemene, (R)-limonene, (S)-limonene, myrcene, sabinene), which are the main constituents of essential oil obtained from Mutellina purpurea L., a plant with described antitubercular activity, to investigate their interactions with antibiotics against reference Mtb strains and multidrug-resistant clinical isolates...
January 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29341030/new-tirucallane-type-triterpenoids-from-guarea-guidonia
#5
Vanessa Hernandez, Marinella De Leo, Roberta Cotugno, Alessandra Braca, Nunziatina De Tommasi, Lorella Severino
The aerial parts of Guarea guidonia afforded three new tirucallane-type triterpenoids: 3,4-seco-tirucalla-4(28),8(9),24(25)-trien-7α,11α-dihydroxy-21,23-epoxy-3,11-olide, named guareolide (1: ), 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21-hydroxy-21,23-epoxy-3-oic acid, named guareoic acid A (2: ), and 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21,23-epoxy-3-oic acid, named guareoic acid B (3: ), of which 1: possessed an unusual seven-membered lactone ring. Seven known terpenes were also isolated and characterized as flindissone, 7-acetyldihydronomilin, picroquassin E, boscartol C, and cneorubins A, B, and X...
January 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29339971/terzyme-a-tool-for-identification-and-analysis-of-the-plant-terpenome
#6
Piyush Priya, Archana Yadav, Jyoti Chand, Gitanjali Yadav
Background: Terpenoid hydrocarbons represent the largest and most ancient group of phytochemicals, such that the entire chemical library of a plant is often referred to as its 'terpenome'. Besides having numerous pharmacological properties, terpenes contribute to the scent of the rose, the flavors of cinnamon and the yellow of sunflowers. Rapidly increasing -omics datasets provide an unprecedented opportunity for terpenome detection, paving the way for automated web resources dedicated to phytochemical predictions in genomic data...
2018: Plant Methods
https://www.readbyqxmd.com/read/29338341/rna-sequencing-on-amomum-villosum-lour-induced-by-meja-identifies-the-genes-of-wrky-and-terpene-synthases-involved-in-terpene-biosynthesis
#7
Xueying He, Huan Wang, Jinfen Yang, Ke Deng, Teng Wang
Amomum villosum Lour. is an important Chinese medicine that has diverse medicinal functions, and mainly contains volatile terpenes This study aimed to explore the WRKY transcription factors (TFs) and terpene synthases (TPS) unigenes, which might be involved in terpene biosynthesis in A. villosum for providing some new information on the regulation of terpenes in plants. RNA sequencing of A.villosum-induced by methyl jasmonate (MeJA) revealed WRKY family was the second biggest TF family in the transcriptome...
January 16, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29334799/potential-of-epr-spin-trapping-to-investigate-in-situ-free-radicals-generation-from-skin-allergens-in-reconstructed-human-epidermis-cumene-hydroperoxide-as-proof-of-concept
#8
Salen Kuresepi, Bertrand Vileno, Philippe Turek, Jean-Pierre Lepoittevin, Elena Giménez-Arnau
The first step in the development of skin sensitisation to a chemical, and in the elicitation of further allergic contact dermatitis (ACD), is the binding of the allergen to skin proteins after penetrating into the epidermis. The so-formed antigenic adduct is then recognised by the immune system as foreign to the body. Sensitising organic hydroperoxides derived from autoxidation of natural terpenes are believed to form antigens through radical-mediated mechanisms, although this has not yet been established...
January 15, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29329850/gc-ms-profiling-descriptive-sensory-analysis-and-consumer-acceptance-of-costa-rican-papaya-carica-papaya-l-fruit-purees
#9
Veronika M Lieb, Patricia Esquivel, Elba Cubero Castillo, Reinhold Carle, Christof B Steingass
Volatiles of papaya purees from four Costa Rican cultivars were analysed by solid-phase microextraction and gas chromatography-mass spectrometry. A total of 83 volatiles was assigned in the purees, of which 19 were detected for the first time as papaya constituents. As revealed by multivariate statistics, i.e., principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), the purees may be allocated to terpene- and lactone-rich ('SH-5'), ester-containing ('Criolla'), and intermediate chemotypes ('Pococí' and 'Silvestre')...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29323912/evaluation-of-diarylheptanoid-terpene-adduct-enantiomers-from-alpinia-officinarum-for-neuroprotective-activities
#10
Hui Liu, Zhen-Long Wu, Xiao-Jun Huang, Yinghui Peng, Xiaojie Huang, Lei Shi, Ying Wang, Wen-Cai Ye
Two pairs of new diarylheptanoid-monoterpene adduct enantiomers, (±)-alpininoids A and B [(±)-1 and (±)-2], as well as three pairs of new diarylheptanoid-sesquiterpene adduct enantiomers, (±)-alpininoids C-E [(±)-3-(±)-5], together with four known diarylheptanoids (6-9) were isolated from the rhizomes of Alpinia officinarum. Their structures with absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses and computational calculation methods. The skeletons of these cyclohexene-containing hybrid natural products were hypothesized to be generated via a crucial Diels-Alder cycloaddition between the diarylheptanoids (7 and 8) and terpenes, of which 1 represents a new carbon skeleton...
January 11, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29323202/genome-based-classification-of-micromonosporae-with-a-focus-on-their-biotechnological-and-ecological-potential
#11
Lorena Carro, Imen Nouioui, Vartul Sangal, Jan P Meier-Kolthoff, Martha E Trujillo, Maria Del Carmen Montero-Calasanz, Nevzat Sahin, Darren Lee Smith, Kristi E Kim, Paul Peluso, Shweta Deshpande, Tanja Woyke, Nicole Shapiro, Nikos C Kyrpides, Hans-Peter Klenk, Markus Göker, Michael Goodfellow
There is a need to clarify relationships within the actinobacterial genus Micromonospora, the type genus of the family Micromonosporaceae, given its biotechnological and ecological importance. Here, draft genomes of 40 Micromonospora type strains and two non-type strains are made available through the Genomic Encyclopedia of Bacteria and Archaea project and used to generate a phylogenomic tree which showed they could be assigned to well supported phyletic lines that were not evident in corresponding trees based on single and concatenated sequences of conserved genes...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319806/comparative-genomics-highlights-symbiotic-capacities-and-high-metabolic-flexibility-of-the-marine-genus-pseudovibrio
#12
Dennis Versluis, Bart Nijsse, Mohd Azrul Naim, Jasper J Koehorst, Jutta Wiese, Johannes F Imhoff, Peter J Schaap, Mark W J van Passel, Hauke Smidt, Detmer Sipkema
Pseudovibrio is a marine bacterial genus members of which are predominantly isolated from sessile marine animals, and particularly sponges. It has been hypothesised that Pseudovibrio spp. form mutualistic relationships with their hosts. Here, we studied Pseudovibrio phylogeny and genetic adaptations that may play a role in host colonization by comparative genomics of 31 Pseudovibrio strains, including 25 sponge isolates. All genomes were highly similar in terms of encoded core metabolic pathways, albeit with substantial differences in overall gene content...
January 8, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29318969/confronting-penetration-threshold-via-fluidic-terpenoid-nanovesicles
#13
Kamla Pathak, Ankur Vaidya, Vijay Sharma
BACKGROUND: Improvisation of the nanosized vesicular systems has led to a series of useful developments including the deformable vesicles namely transfersomes, ethosomes and invasomes. While the former two have been explored extensively, literature on invasomes is relatively scanty. METHOD: Invasomal formulations researched for various applications have been reviewed using search engine "Scopus". The present review focuses on the update on the research activity on effectiveness and permeation enhancing effects of invasomes for dermal and topical delivery...
January 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29318237/sustainable-terpene-based-polyamides-via-anionic-polymerization-of-a-pinene-derived-lactam
#14
Malte Winnacker, Jacob Sag
A sustainable lactam, which is derived from the renewable terpene β-pinene, is converted to polyamides via a convenient anionic ring-opening polymerization (ROP), which can be easily handled without the use of a costly catalyst. The resulting polyamides have prosperous thermal properties, which enable their future use as high-performance polymers.
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29306697/current-sleep-disturbance-in-older-people-with-a-lifetime-history-of-depression-is-associated-with-increased-connectivity-in-the-default-mode-network
#15
Andrew C McKinnon, Ian B Hickie, Jan Scott, Shantel L Duffy, Louisa Norrie, Zoe Terpening, Ron R Grunstein, Jim Lagopoulos, Jennifer Batchelor, Simon J G Lewis, James M Shine, Sharon L Naismith
BACKGROUND: The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. METHODS: A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted)...
December 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29304410/simultaneous-quantitative-determination-of-bioactive-terpene-indole-alkaloids-in-ethanolic-extracts-of-catharanthus-roseus-l-g-don-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#16
Sunil Kumar, Awantika Singh, Brijesh Kumar, Bikarma Singh, Lal Bahadur, Mohan Lal
A rapid, sensitive and reproducible method using ultra-high-performance liquid chromatography coupled with electrospray ionization hybrid triple quadrupole-linear ion trap mass spectrometry (UHPLC-ESI-QqQLIT-MS/MS) in multiple reaction monitoring (MRM) mode was developed and validated for simultaneous quantitation of anticancer (vincristine, vinblastine, vindesine), antihypertensive (ajmaline, ajmalicine, reserpine), aphrodisiac (yohimbine), sedative (serpentine) agents, dietary supplement (vinpocetine, yohimbine) and precursor of vinblastine (vindoline) from crude extracts of Catharanthus roseus...
December 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29301045/ozone-triggered-surface-uptake-and-stress-volatile-emissions-in-nicotiana-tabacum-wisconsin
#17
Arooran Kanagendran, Leila Pazouki, Shuai Li, Bin Liu, Astrid Kännaste, Ülo Niinemets
Ozone is a strong oxidant and a key stress elicitor. The immediate and longer term impacts of ozone are poorly understood in species with emission of both de novo synthesized and stored volatiles, such a tobacco (Nicotiana tabacum), which has terpene-containing glandular trichomes on the leaf surface. In this study, we exposed N. tabacum 'Wisconsin' leaves to acute ozone doses of 0 (control), 400, 600, 800, and 1000 ppb for 30 min and studied the effects of ozone exposure on ozone uptake, gas-exchange characteristics, and emissions of lipoxygenase pathway volatiles, monoterpenes, and sesquiterpenes...
December 30, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29296983/enhanced-structural-diversity-in-terpenoid-biosynthesis-enzymes-substrates-and-cofactors
#18
REVIEW
Abith Vattekkatte, Stefan Garms, Wolfgang Brandt, Wilhelm Boland
The enormous diversity of terpenes found in nature is generated by enzymes known as terpene synthases, or cyclases. Some are also known for their ability to convert a single substrate into multiple products. This review comprises monoterpene and sesquiterpene synthases that are multiproduct in nature along with the regulation factors that can alter the product specificity of multiproduct terpene synthases without genetic mutations. Variations in specific assay conditions with focus on shifts in product specificity based on change in metal cofactors, assay pH and substrate geometry are described...
January 3, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29295695/anticancer-properties-of-essential-oils-an-overview
#19
Milene Aparecida Andrade, Mariana Aparecida Braga, Pedro Henrique Souza Cesar, Marcus Vinicius Cardoso Trento, Mariana Araujo Esposito, Lucilene Fernandes Silva
BACKGROUND: Essential oils are complex mixtures of low molecular weight compounds extracted from plants. Their main constituents are terpenes and phenylpropanoids, which are responsible for their biological and pharmaceutical properties, such as insecticidal, parasiticidal, antimicrobial, antioxidant, anti-inflammatory, analgesic, antinociceptive, anticarcinogenic, and antitumor properties. Cancer is a complex genetic disease considered as a serious public health problem worldwide, accounting for more than 8 million deaths annually...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29288759/the-frequently-occurring-components-of-essential-oils-beta-elemene-and-r-limonene-alter-expression-of-dpre1-and-clgr-genes-of-mycobacterium-tuberculosis-h37ra
#20
Rafal Sawicki, Elwira Sieniawska, Marta Swatko-Ossor, Joanna Golus, Grazyna Ginalska
In the past few years, there has been a significant increase in detection of drug resistant strains of Mycobacterium tuberculosis. Search for new antimycobacterial drugs brought natural sources with their chemical diversity in focus. Especially essential oils, produced by plants also for toxic effect, are reservoir of potentially antitubercular compounds. In the present work, we exposed M. tuberculosis H37Ra ATCC 25177 strain to some terpenes commonly occurring in essential oils. Gene expression profiling was used to explore possible influence of these compounds on stress sensing and envelope preserving function...
December 27, 2017: Food and Chemical Toxicology
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