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https://www.readbyqxmd.com/read/28819677/direct-analysis-of-terpenes-from-biological-buffer-systems-using-sesi-and-ir-maldesi
#1
Milad Nazari, Alexandra A Malico, Måns Ekelöf, Sean Lund, Gavin J Williams, David C Muddiman
Terpenes are the largest class of natural products with a wide range of applications including use as pharmaceuticals, fragrances, flavorings, and agricultural products. Terpenes are biosynthesized by the condensation of a variable number of isoprene units resulting in linear polyisoprene diphosphate units, which can then be cyclized by terpene synthases into a range of complex structures. While these cyclic structures have immense diversity and potential in different applications, their direct analysis in biological buffer systems requires intensive sample preparation steps such as salt cleanup, extraction with organic solvents, and chromatographic separations...
August 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28814142/effect-of-terpenes-on-transdermal-iontophoretic-delivery-of-diclofenac-potassium-under-constant-voltage
#2
Arunkumar S, Shivakumar H N, S Narasimha Murthy
PURPOSE: The aim of the study was to enhance the transdermal delivery of diclofenac potassium (DP) from hydrogels by constant voltage iontophoresis (CVI). The other objective was to establish the safety and efficacy of CVI in rats. METHODS: Hydrogels of DP were developed using hydroxyethyl cellulose as matrix material and geraniol, l-menthol and thymol as iontophoretic efficiency enhancers (IEE). In vitro permeation of hydrogels under CVI (1.5V) was performed in Franz diffusion cells across porcine skin...
August 17, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28813102/terpene-esters-from-natural-products-synthesis-and-evaluation-of-cytotoxic-activity
#3
Mauricio M Victor, Jorge M David, Maria C K Sakukuma, Letícia V Costa-Lotufo, Andrea F Moura, Ana J Araújo
Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28808822/is-prey-specificity-constrained-by-geography-semiochemically-mediated-oviposition-in-rhizophagus-grandis-coleoptera-monotomidae-with-its-specific-prey-dendroctonus-micans-coleoptera-curculionidae-scolytinae-and-with-exotic-dendroctonus-species
#4
Loïc Dohet, Jean-Claude Grégoire
Examples of totally specific predators are rare, and the mechanisms underlying this specificity are often poorly understood. In Eurasia, the Monotomid beetle Rhizophagus grandis is found only in the galleries of its prey, the bark beetle Dendroctonus micans. The specificity of R. grandis relies on kairomones which female predators use to adjust their oviposition to the number of prey larvae available in a gallery. Yet these chemical signals are still largely unknown. The North American D. punctatus and D. valens, which are not sympatric with R...
August 14, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28807230/global-identification-of-chemical-constituents-and-rat-metabolites-of-si-miao-wan-by-liquid-chromatography-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry
#5
Jin-Jin Lu, Xue-Wen Hu, Ping Li, Jun Chen
Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) method was established to identify the multiple constituents of SMW and its metabolites in rat biological samples after oral administration. A total of 48 compounds in SMW, including 21 alkaloids, 12 organic acids, 2 terpenes, 3 lactones, 2 phytosterols, and 8 other compounds, were tentatively characterized with the diagnostic-ion filtering strategy...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28803364/volatile-terpenoids-multiple-functions-biosynthesis-modulation-and-manipulation-by-genetic-engineering
#6
REVIEW
Farhat Abbas, Yanguo Ke, Rangcai Yu, Yuechong Yue, Sikandar Amanullah, Muhammad Muzammil Jahangir, Yanping Fan
Terpenoids play several physiological and ecological functions in plant life through direct and indirect plant defenses and also in human society because of their enormous applications in the pharmaceutical, food and cosmetics industries. Through the aid of genetic engineering its role can by magnified to broad spectrum by improving genetic ability of crop plants, enhancing the aroma quality of fruits and flowers and the production of pharmaceutical terpenoids contents in medicinal plants. Terpenoids are structurally diverse and the most abundant plant secondary metabolites, playing an important role in plant life through direct and indirect plant defenses, by attracting pollinators and through different interactions between the plants and their environment...
August 12, 2017: Planta
https://www.readbyqxmd.com/read/28797912/genome-wide-identification-functional-and-evolutionary-analysis-of-terpene-synthases-in-pineapple
#7
Xiaoe Chen, Wei Yang, Liqin Zhang, Xianmiao Wu, Tian Cheng, Guanglin Li
Terpene synthases (TPSs) are vital for the biosynthesis of active terpenoids, which have important physiological, ecological and medicinal value. Although terpenoids have been reported in pineapple (Ananas comosus), genome-wide investigations of the TPS genes responsible for pineapple terpenoid synthesis are still lacking. By integrating pineapple genome and proteome data, twenty-one putative terpene synthase genes were found in pineapple and divided into five subfamilies. Tandem duplication is the cause of TPS gene family duplication...
July 6, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28780179/cyp106a2-a-versatile-biocatalyst-with-high-potential-for-biotechnological-production-of-selectively-hydroxylated-steroid-and-terpenoid-compounds
#8
REVIEW
Daniela Schmitz, Simon Janocha, Flora Marta Kiss, Rita Bernhardt
CYP106A2 from Bacillus megaterium ATCC13368, was identified in the 1970s as one of the first bacterial steroid hydroxylases responsible for the conversion of progesterone to 15β-hydroxyprogesterone. Later on it has been proven to be a potent hydroxylase of numerous 3-oxo-Δ(4) as well as 3-hydroxy-Δ(5)-steroids and has recently also been characterized as a regioselective allylic bacterial diterpene hydroxylase. The main hydroxylation position of CYP106A2 is thought to be influenced by the functional groups at C3 position in the steroid core leading to a favored 15β-hydroxylation of 3-oxo-Δ(4)-steroids and 7β-hydroxylation of 3-hydroxy-Δ(5)-steroids...
August 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28772002/chemo-enzymatic-synthesis-of-a-novel-borneol-based-polyester
#9
Steffen Roth, Irina Funk, Michael Hofer, Volker Sieber
Terpenes are a class of natural compounds that have recently moved into the focus as bio-based resource for chemicals productions due to their abundance, their mostly cyclic structure and the presence of olefin or single hydroxyl groups. In order to apply this raw material in new industrial fields, a second hydroxyl group is inserted into borneol by cytochrome P450cam (CYP101) enzymes in a whole cell catalytic biotransformation with Pseudomonas putida KT2440. Next, a semi-continuous batch system was developed to produce 5-exo-hydroxyborneol with a final concentration of 0...
August 3, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28771760/transcriptome-analysis-of-terpene-chemotypes-of-melaleuca-alternifolia-across-different-tissues
#10
Carlos Bustos-Segura, Amanda Padovan, David Kainer, William J Foley, Carsten Külheim
Plant chemotypes or chemical polymorphisms are defined by discrete variation in secondary metabolites within a species. This variation can have consequences for ecological interactions or the human use of plants. Understanding the molecular basis of chemotypic variation can help to explain how variation of plant secondary metabolites is controlled. We explored the transcriptomes of the three cardinal terpene chemotypes of Melaleuca alternifolia in young leaves, mature leaves and stem and compared transcript abundance to variation in the constitutive profile of terpenes...
August 3, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28768955/special-issue-symposium-on-the-chemistry-of-terpenes-essential-oils-and-aromatics-teac
#11
Mitsuo Miyazawa, Yoshinori Asakawa
No abstract text is available yet for this article.
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28767894/comparative-toxicity-of-essential-oil-and-blends-of-selected-terpenes-of-ocotea-species-from-pernambuco-brazil-against-tetranychus-urticae-koch
#12
Marcilio M DE Moraes, Claudio A G DA Camara, Milena M C DA Silva
Essential oils from the leaves of two species of the genus Ocotea that occur in the Atlantic Forest in the state of Pernambuco, Brazil, were analyzed using gas chromatography-mass spectrometry. The acaricidal activity of these oils as well as 11 selected components and blends were evaluated in fumigation and residual contact tests against the two-spotted spider mite (Tetranychus urticae). Sixty-seven constituents were identified, totaling 97.3 ± 0.3% and 97.8 ± 0.5% of the oils from O. duckei and O. glomerata, respectively...
July 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28767887/clusia-criuva-cambess-clusiaceae-anatomical-characterization-chemical-prospecting-and-antioxidant-activity
#13
Karla M M DA Silva, Andrea B DA Nóbrega, Bruno Lessa, Maria Carolina Anholeti, Adriana Q Lobão, Alessandra L Valverde, Selma R DE Paiva, Ana Joffily
This study aims the anatomical description and chemical characterization of aerial parts of Clusia criuva Cambess., Clusiaceae in addition to the evaluation of the antioxidant activity of crude extracts, correlated to the flavonoid content. The morphological characterization was performed using traditional techniques of plant anatomy. For phytochemical studies, crude extracts were obtained by static maceration and analyzed by thin layer chromatography. The antioxidant activity and the flavonoids content were determined by colorimetric methods involving, respectively, 2,2-diphenyl-1-picrylhydrazyl free radical and aluminum chloride...
July 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28767008/the-edible-mushroom-pleurotus-djamor-produces-metabolites-with-lethal-activity-against-the-parasitic-nematode-haemonchus-contortus
#14
Jesús Antonio Pineda-Alegría, José Ernesto Sánchez-Vázquez, Manases González-Cortazar, Alejandro Zamilpa, María Eugenia López-Arellano, Edgar Josúe Cuevas-Padilla, Pedro Mendoza-de-Gives, Liliana Aguilar-Marcelino
Pleurotus djamor is an edible mushroom that has medicinal properties. This study aimed to assess the in vitro activity of P. djamor extracts and fractions against Haemonchus contortus eggs and exsheathed infective larvae (L3). Crude hydroalcoholic extracts were obtained by maceration and fractions were obtained through chromatography. Metabolite identity was determined using gas chromatography/mass spectrometry (GC-MS) analysis. The results showed that P. djamor extracts had no significant activity against eggs at the concentrations used...
August 2, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28764010/effects-of-sunlight-exclusion-on-the-profiles-of-monoterpene-biosynthesis-and-accumulation-in-grape-exocarp-and-mesocarp
#15
Erpeng Zhang, Fengmei Chai, Haohao Zhang, Shaohua Li, Zhenchang Liang, Peige Fan
Terpenes are important aroma compounds in table Muscat grape and wine, and their content in the berry can be affected by sunlight. The effects of sunlight exclusion on monoterpene profiles and relevant gene expression profiles in the exocarp and mesocarp of table Muscat grape 'Jingxiangyu' at different development stages were thoroughly surveyed by bagging pre-veraison clusters in special opaque boxes. The responses of monoterpenes to sunlight treatments varied in three types, representatively linalool, ocimene and geraniol...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763707/molecular-cloning-and-functional-characterization-of-a-monoterpene-synthase-isolated-from-the-aromatic-wild-shrub-thymus-albicans
#16
Alexandra Filipe, João C R Cardoso, Graça Miguel, Liliana Anjos, Helena Trindade, Ana Cristina Figueiredo, José Barroso, Deborah M Power, Natália T Marques
The essential oil of Thymus albicans Hoffmanns. & Link, a native shrub from the Iberian Peninsula, is mainly composed of monoterpenes. In this study, a 1,8-cineole synthase was isolated from the 1,8-cineole chemotype. A partial sequence that lacked the complete plastid transit peptide but contained an extended C-terminal when compared to other related terpene synthases was generated by PCR and Rapid Amplification of cDNA Ends (RACE). The predicted mature polypeptide was 593 amino acids in length and shared 78% and 77% sequence similarity with the homologue 1,8-cineole synthase from Rosmarinus officinalis and Salvia officinalis, respectively...
July 21, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28757593/sechium-edule-jacq-swartz-a-new-cultivar-with-antiproliferative-potential-in-a-human-cervical-cancer-hela-cell-line
#17
Sandra Salazar-Aguilar, Lucero Del Mar Ruiz-Posadas, Jorge Cadena-Iñiguez, Marcos Soto-Hernández, Edelmiro Santiago-Osorio, Itzen Aguiñiga-Sánchez, Ana Rocío Rivera-Martínez, Juan Francisco Aguirre-Medina
The Sechium edule Perla Negra cultivar is a recently-obtained biological material whose progenitors are S. edule var. nigrum minor and S. edule var. amarus silvestrys, the latter of which has been reported to have antiproliferative activity against the HeLa P-388 and L-929 cancer cell lines. The present study aimed to determine if the methanolic extract of the fruit of the Perla Negra cultivar had the same biological activity. The methanolic extract was phytochemically characterized by thin layer chromatography (TLC) and column chromatography (CC), identifying the terpenes and flavonoids...
July 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28756673/the-evolution-of-volatile-compounds-during-the-distillation-of-cognac-spirit
#18
Pierre Awad, Violaine Athès-Dutour, Martine Decloux, Gérald Ferrari, Guillaume Snakkers, Patrick Raguenaud, Pierre Giampaoli
Cognac wine spirit has a complex composition in volatile compounds which contribute to its organoleptic profile. This work focused on the batch distillation process and, in particular, on volatile compounds specifically produced by chemical reactions during the distillation of Cognac wine spirit, traditionally conducted in two steps with charentais pot stills. The aim of this study was to characterize these volatile compounds formed during distillation. Sampling has been performed on the distillates and inside the boiler during a typical Cognac distillation...
July 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28751314/biosynthesis-of-diterpenoids-in-tripterygium-adventitious-root-cultures
#19
Fainmarinat Inabuy, Justin T Fischedick, Iris Lange, Michael Hartmann, Narayanan Srividya, Amber N Parrish, Meimei Xu, Reuben J Peters, Bernd Markus Lange
Adventitious root cultures were developed from Tripterygium regelii Sprague & Takeda and growth conditions optimized for the abundant production of diterpenoids, which can be collected directly from the medium. An analysis of publicly available transcriptome data sets collected with T. regelii roots and root cultures indicated the presence of a large gene family (with 20 members) for terpene synthases (TPSs). Nine candidate diterpene synthase genes were selected for follow-up functional evaluation, of which two belonged to the TPS-c, three to the TPS-e/f and four to the TPS-b subfamily...
July 27, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28749029/ecotype-variation-of-methyl-eugenol-content-in-tea-tree-melaleuca-alternifolia-and-m-linariifolia
#20
Mervyn Shepherd, Dale Savins, Ashley Dowell, Samantha Morrow, Gareth Allen, Ian Southwell
Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics and health-care. As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. Consequently, its level has been restricted in some foodstuffs and cosmetics for some markets. In order to assess the potential to breed uniformly low methyl eugenol cultivars for an essential oil crop, tea tree, the source of "Oil of Melaleuca, terpinene-4-ol type", we examine levels in individual trees (n= 30) from two geographic regions and six terpene chemotypes...
July 27, 2017: Chemistry & Biodiversity
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