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Prostate multiparametric imaging

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https://www.readbyqxmd.com/read/29770311/-super-active-surveillance-mri-ultrasound-fusion-biopsy-and-ablation-for-less-invasive-management-of-prostate-cancer
#1
REVIEW
Jonathan B Bloom, Samuel A Gold, Graham R Hale, Kareem N Rayn, Vikram K Sabarwal, Ivane Bakhutashvili, Vladimir Valera, Baris Turkbey, Peter A Pinto, Bradford J Wood
Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29770305/the-prostate-cancer-focal-therapy
#2
REVIEW
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Edoardo Zanchetta, Chiara Floridi, Gianpaolo Carrafiello, Chloë Standaert
Despite prostate cancer (PCa) is the leading form of non-cutaneous cancer in men, most patients with PCa die with disease rather than of the disease. Therefore, the risk of overtreatment should be considered by clinicians who have to distinguish between patients with high risk PCa (who would benefit from radical treatment) and patients who may be managed more conservatively, such as through active surveillance or emerging focal therapy (FT). The aim of FT is to eradicate clinically significant disease while protecting key genito-urinary structures and function from injury...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29753548/fusion-prostate-biopsy-outperforms-12-core-systematic-prostate-biopsy-in-patients-with-prior-negative-systematic-biopsy-a-multi-institutional-analysis
#3
Abhinav Sidana, Matthew J Watson, Arvin K George, Ardeshir R Rastinehad, Srinivas Vourganti, Soroush Rais-Bahrami, Akhil Muthigi, Mahir Maruf, Jennifer B Gordetsky, Jeffrey W Nix, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
INTRODUCTION AND OBJECTIVES: Patients with persistently elevated prostate specific antigen (PSA) and prior negative 12-core TRUS prostate biopsy (or biopsies) (systematic biopsy-SBx) are a diagnostic challenge. Repeat SBx or saturation biopsy in this cohort has been shown to have an even lower yield. The aim of our study is to compare the prostate cancer yield of magnetic resonance imaging (MRI) fusion biopsy (FBx) to SBx in a multi-institutional cohort comprised of patients with prior negative biopsies...
May 9, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29752647/multiparametric-magnetic-resonance-imaging-versus-partin-tables-and-the-memorial-sloan-kettering-cancer-center-nomogram-in-risk-stratification-of-patients-with-prostate-cancer-referred-to-external-beam-radiation-therapy
#4
Rossano Girometti, Martina Pancot, Marco Andrea Signor, Martina Urbani, Luca Balestreri, Chiara Zuiani
PURPOSE: To evaluate the agreement between multiparametric Magnetic Resonance Imaging (mpMRI), Partin tables (PT) and the Memorial Sloan Kettering Cancer Center nomogram (MSKCCn) in assessing risk category in prostate cancer (PCa) patients referred to External Beam Radiotherapy (EBRT). MATERIALS AND METHODS: In this bicentric study, we prospectively enrolled 80 PCa patients who underwent pre-EBRT mpMRI on a 3.0T magnet with a multiparametric protocol including high-resolution, multiplanar T2-weighted sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29734177/multiparametric-magnetic-resonance-to-confirm-eligibility-to-an-active-surveillance-program-for-low-risk-prostate-cancer-intermediate-time-results-of-a-third-referral-high-volume-centre-active-surveillance-protocol
#5
Stefano Luzzago, Gennaro Musi, Michele Catellani, Andrea Russo, Ettore Di Trapani, Francesco Alessandro Mistretta, Roberto Bianchi, Gabriele Cozzi, Andrea Conti, Paola Pricolo, Matteo Ferro, Deliu-Victor Matei, Vincenzo Mirone, Giuseppe Petralia, Ottavio de Cobelli
BACKGROUND: To evaluate the role of confirmatory multiparametric magnetic resonance imaging (mpMRI) of the prostate at the time of Active Surveillance (AS) enrollment to reduce disease misclassification. MATERIALS: From 2012 to 2016, 383 patients with low-risk disease respecting Prostate Cancer Research International AS criteria underwent confirmatory 1.5-T mpMRI. AS was proposed to patients with Prostate Imaging and Report and Data System (PI-RADS) score ≤3 and no extraprostatic extension (EPE), whereas patients with PI-RADS score ≥4 and/or EPE were treated actively...
May 7, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29733838/validation-of-pi-rads-version-2-for-the-detection-of-prostate-cancer
#6
Sebastian L Hofbauer, Beatrice Kittner, Andreas Maxeiner, Robin Heckmann, Maximillian Reimann, Laura Wiemer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Carsten Stephan, Frank Friedersdorff, Florian Fuller, Kurt Miller, Hannes Cash
PURPOSE: The second version of the Prostate Imaging Reporting and Data System (PI-RADSv2) was introduced in 2015 to standardize the interpretation and reporting of multiparametric prostate magnetic resonance imaging (mpMRI). Recently, low cancer detection rates (CDR) for PI-RADSv2 category 4 lesions were reported. Therefore the aim of the study was to evaluate the CDR of PI-RADSv2 in a large prospective cohort. METHODS: The study included 704 consecutive men with primary or prior negative biopsies who underwent MRI/ultrasound fusion-guided targeted biopsy (TB) and 10-core systematic prostate biopsy (SB) between September 2015 and May 2017...
May 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29733790/pi-rads-v2-current-standing-and-future-outlook
#7
REVIEW
Clayton P Smith, Barış Türkbey
The Prostate Imaging-Reporting and Data System (PI-RADS) was created in 2012 to establish standardization in prostate multiparametric magnetic resonance imaging (mpMRI) acquisition, interpretation, and reporting. In hopes of improving upon some of the PI-RADS v1 shortcomings, the PI-RADS Steering Committee released PI-RADS v2 in 2015. This paper reviews the accuracy, interobserver agreement, and clinical outcomes of PI-RADS v2 and comments on the limitations of the current literature. Overall, PI-RADS v2 shows improved sensitivity and similar specificity compared to PI-RADS v1...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29733695/can-apparent-diffusion-coefficient-values-assist-pi-rads-version-2-dwi-scoring-a-correlation-study-using-the-pi-radsv2-and-international-society-of-urological-pathology-systems
#8
Sonia Gaur, Stephanie Harmon, Lauren Rosenblum, Matthew D Greer, Sherif Mehralivand, Mehmet Coskun, Maria J Merino, Bradford J Wood, Joanna H Shih, Peter A Pinto, Peter L Choyke, Baris Turkbey
OBJECTIVE: The purposes of this study were to assess correlation of apparent diffusion coefficient (ADC) and normalized ADC (ratio of tumor to nontumor tissue) with the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and updated International Society of Urological Pathology (ISUP) categories and to determine how to optimally use ADC metrics for objective assistance in categorizing lesions within PI-RADSv2 guidelines. MATERIALS AND METHODS: In this retrospective study, 100 patients (median age, 62 years; range, 44-75 years; prostate-specific antigen level, 7...
May 7, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29732281/imaging-for-the-selection-and-monitoring-of-men-on-active-surveillance-for-prostate-cancer
#9
REVIEW
Maria C Velasquez, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruno Nahar, Sanoj Punnen
Traditional prostate imaging is fairly limited, and only a few imaging modalities have been used for this purpose. Until today, grey scale ultrasound was the most widely used method for the characterization of the prostatic gland, however its limitations for prostate cancer (PCa) detection are well known and hence ultrasound is primarily used to localize the prostate and facilitate template prostate biopsies. In the past decade, multiparametric magnetic resonance imaging (mpMRI) of the prostate has emerged as a promising tool for the detection of PCa...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29732280/expanded-criteria-for-active-surveillance-in-prostate-cancer-a-review-of-the-current-data
#10
REVIEW
Cameron Jones, Mina M Fam, Benjamin J Davies
Over the last ten years, active surveillance (AS) has become increasingly utilized for patients with low-risk prostate cancer. Appropriately selected AS patients have a 10-year prostate cancer-specific mortality (PCSM) approaching 99%. Therefore, some institutions have expanded the inclusion criteria for AS to avoid the unnecessary morbidity associated with overtreatment. In this review, data from several high-quality studies were compiled to demonstrate how AS inclusion criteria may be safely expanded. Although AS criteria, data reporting, and statistical methods were heterogeneous across studies, several findings were consistent and provided insight for clinical practice...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29730256/the-role-of-imaging-in-prostate-cancer-care-pathway-novel-approaches-to-urologic-management-challenges-along-ten-imaging-touch-points
#11
REVIEW
Qian Li, Feixiang Xiang, Xueying Lin, Joseph R Grajo, Long Yang, Yufeng Xu, Yu Duan, Urvi Vyas, Mukesh Harisinghani, Umar Mahmood, Anthony E Samir
We map out a typical prostate cancer care pathway through discussion of updates on modern imaging. Multiparametric MRI (mpMRI) is the most sensitive and specific imaging tool for diagnosis and local staging, transrectal ultrasound remains the most widely used technique for prostate biopsy guidance, CT and bone scan are useful in initial staging and recurrence detection. Novel imaging techniques in ultrasound elastography and mpMRI allow for increased lesion detection sensitivity and have the potential to enhance biopsy, while the development of new PET radiotracers has great promise for improved detection of local and metastatic disease in patients with biochemical recurrence...
May 3, 2018: Urology
https://www.readbyqxmd.com/read/29727817/endorectal-mr-imaging-of-prostate-cancer-evaluation-of-tumor-capsular-contact-length-as-a-sign-of-extracapsular-extension
#12
Gustavo Mendez, Bryan R Foster, Xin Li, Jackilen Shannon, Mark Garzotto, Christopher L Amling, Fergus V Coakley
OBJECTIVE: To evaluate the length of contact between dominant tumor foci and the prostatic capsule as a sign of extracapsular extension at endorectal multiparametric MR imaging. MATERIALS AND METHODS: We retrospectively identified 101 patients over a three-year interval who underwent endorectal multiparametric prostate MR imaging prior to radical prostatectomy for prostate cancer. Two readers identified the presence of dominant tumor focus (largest lesion with PI-RADS version 2 score of 4 or 5), and measured the length of tumor capsular contact and likelihood of extracapsular extension by standard criteria (1-5 Likert scale)...
April 25, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29725743/3t-multiparametric-mr-imaging-piradsv2-based-detection-of-index-prostate-cancer-lesions-in-the-transition-zone-and-the-peripheral-zone-using-whole-mount-histopathology-as-reference-standard
#13
Nazanin Hajarol Asvadi, Sohrab Afshari Mirak, Amirhossein Mohammadian Bajgiran, Pooria Khoshnoodi, Pornphan Wibulpolprasert, Daniel Margolis, Anthony Sisk, Robert E Reiter, Steven S Raman
PURPOSE: To evaluate 3T mpMRI characteristics of transition zone and peripheral zone index prostate cancer lesions stratified by Gleason Score and PI-RADSv2 with whole mount histopathology correlation. METHODS: An institution review board-approved, HIPAA-compliant single-arm observational study of 425 consecutive men with 3T mpMRI prior to radical prostatectomy from December 2009 to October 2016 was performed. A genitourinary radiologist and a genitourinary pathologist matched all lesions detected on whole mount histopathology with lesions concordant for size and location on 3T mpMRI...
May 3, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29718792/a-younger-man-with-localized-prostate-cancer-asks-which-type-of-radiation-is-right-for-me
#14
Justin E Bekelman
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29715138/comparing-image-guided-targeted-biopsies-to-radical-prostatectomy-specimens-for-accurate-characterization-of-the-index-tumor-in-prostate-cancer
#15
Francesco Porpiglia, Stefano DE Luca, Enrico Checcucci, Diletta Garrou, Matteo Manfredi, Fabrizio Mele, Angela Pecoraro, Roberto Passera, Enrico Bollito, Cristian Fiori
AIM: To evaluate the accuracy of multiparametric magnetic resonance-transrectal ultrasound fusion targeted biopsy (TBx) in the characterization of the index tumor, as confirmed by association with radical prostatectomy (RP) specimens. PATIENTS AND METHODS: A total of 152 patients with TBx-confirmed prostate cancer (PCa) underwent robot-assisted RP. Stained whole-mount histological sections were used as the reference standard. All lesions with a volume >0.5 ml and/or pathological Gleason score (GS) >6 were defined as clinically significant PCa...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29708783/prebiopsy-multiparametric-mri-with-cancer-negative-findings-in-men-with-suspected-prostate-cancer-evaluation-using-prostate-imaging-reporting-and-data-system-version-2
#16
Jun Gon Kim, Chan Kyo Kim, Jae-Hun Kim
OBJECTIVE: The purpose of this study is to investigate the rates and characteristics of missed cancers at prebiopsy multiparametric MRI with cancer-negative findings according to the Prostate Imaging Reporting and Data System (PI-RADS) version 2 in men with suspected prostate cancer (PCa). MATERIALS AND METHODS: A total of 584 consecutive men (biopsy naive, n = 392; repeated biopsy, n = 192) with suspected PCa who underwent prebiopsy 3-T multipara-metric MRI, followed by subsequent biopsies, were enrolled...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29705281/a-multireader-exploratory-evaluation-of-individual-pulse-sequence-cancer-detection-on-prostate-multiparametric-magnetic-resonance-imaging-mri
#17
Sonia Gaur, Stephanie Harmon, Rajan T Gupta, Daniel J Margolis, Nathan Lay, Sherif Mehralivand, Maria J Merino, Bradford J Wood, Peter A Pinto, Joanna H Shih, Peter L Choyke, Baris Turkbey
RATIONALE AND OBJECTIVES: To determine independent contribution of each prostate multiparametric magnetic resonance imaging (mpMRI) sequence to cancer detection when read in isolation. MATERIALS AND METHODS: Prostate mpMRI at 3-Tesla with endorectal coil from 45 patients (n = 30 prostatectomy cases, n = 15 controls with negative magnetic resonance imaging [MRI] or biopsy) were retrospectively interpreted. Sequences (T2-weighted [T2W] MRI, diffusion-weighted imaging [DWI], and dynamic contrast-enhanced [DCE] MRI; N = 135) were separately distributed to three radiologists at different institutions...
April 25, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29702017/is-prostate-imaging-reporting-and-data-system-version-2-sufficiently-discovering-clinically-significant-prostate-cancer-per-lesion-radiology-pathology-correlation-study
#18
Myoung Seok Lee, Min Hoan Moon, Young A Kim, Chang Kyu Sung, Hyunsik Woo, Hyeon Jeong, Hwancheol Son
OBJECTIVE: The objective of our study was to evaluate the performance of multiparametric MRI with Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) for detecting prostate cancer (PCA) and clinically significant PCA through this per-lesion one-toone correlation study between pathologically proven lesions and MRI-visible lesions. MATERIALS AND METHODS: A total of 93 PCA lesions from 44 patients who underwent radical prostatectomy were included in this retrospective study...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29698083/voxel-wise-prostate-cell-density-prediction-using-multiparametric-magnetic-resonance-imaging-and-machine-learning
#19
Yu Sun, Hayley M Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Annette Haworth
BACKGROUND: There are currently no methods to estimate cell density in the prostate. This study aimed to develop predictive models to estimate prostate cell density from multiparametric magnetic resonance imaging (mpMRI) data at a voxel level using machine learning techniques. MATERIAL AND METHODS: In vivo mpMRI data were collected from 30 patients before radical prostatectomy. Sequences included T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
April 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29685613/cognitive-versus-software-assisted-registration-development-of-a-new-nomogram-predicting-prostate-cancer-at-mri-targeted-biopsies
#20
Sascha Kaufmann, Giorgio I Russo, Wolfgang Thaiss, Mike Notohamiprodjo, Fabian Bamberg, Jens Bedke, Giuseppe Morgia, Konstantin Nikolaou, Arnulf Stenzl, Stephan Kruck
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) is gaining acceptance to guide targeted biopsy (TB) in prostate cancer (PC) diagnosis. We aimed to compare the detection rate of software-assisted fusion TB (SA-TB) versus cognitive fusion TB (COG-TB) for PC and to evaluate potential clinical features in detecting PC and clinically significant PC (csPC) at TB. PATIENTS AND METHODS: This was a retrospective cohort study of patients with rising and/or persistently elevated prostate-specific antigen (PSA) undergoing mpMRI followed by either transperineal SA-TB or transrectal COG-TB...
April 3, 2018: Clinical Genitourinary Cancer
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