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Prostate multiparametric imaging

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https://www.readbyqxmd.com/read/28346073/detection-of-clinically-significant-prostate-cancer-short-dual-pulse-sequence-versus-standard-multiparametric-mr-imaging-a-multireader-study
#1
Borna K Barth, Pieter J L De Visschere, Alexander Cornelius, Carlos Nicolau, Hebert Alberto Vargas, Daniel Eberli, Olivio F Donati
Purpose To compare the diagnostic performance of a short dual-pulse sequence magnetic resonance (MR) imaging protocol versus a standard six-pulse sequence multiparametric MR imaging protocol for detection of clinically significant prostate cancer. Materials and Methods This HIPAA-compliant study was approved by the regional ethics committee. Between July 2013 and March 2015, 63 patients from a prospectively accrued study population who underwent MR imaging of the prostate including transverse T1-weighted; transverse, coronal, and sagittal T2-weighted; diffusion-weighted; and dynamic contrast material-enhanced MR imaging with a 3-T imager at a single institution were included in this retrospective study...
March 27, 2017: Radiology
https://www.readbyqxmd.com/read/28344811/the-role-of-imaging-in-the-diagnosis-of-primary-prostate-cancer
#2
Hugh Harvey, Nandita M deSouza
Ultrasound and magnetic resonance imaging (MRI) are key imaging modalities in prostate cancer diagnosis. MRI offers a range of intrinsic contrast mechanisms (T2, diffusion-weighted imaging (DWI), MR spectroscopy (MRS)) and extrinsic contrast-generating options based on tumour vascular state following injection of weakly paramagnetic agents such as gadolinium. Together these parameters are referred to as multiparametric (mp)MRI and are used for detecting and guiding biopsy and staging prostate cancer. Although sensitivity of mpMRI is <75% for disease detection, specificity is >90% and a standardised reporting system together with MR-guided targeted biopsy is the optimal diagnostic pathway...
December 2016: Journal of Clinical Urology
https://www.readbyqxmd.com/read/28336078/what-is-the-negative-predictive-value-of-multiparametric-magnetic-resonance-imaging-in-excluding-prostate-cancer-at-biopsy-a-systematic-review-and-meta-analysis-from-the-european-association-of-urology-prostate-cancer-guidelines-panel
#3
REVIEW
Paul C Moldovan, Thomas Van den Broeck, Richard Sylvester, Lorenzo Marconi, Joaquim Bellmunt, Roderick C N van den Bergh, Michel Bolla, Erik Briers, Marcus G Cumberbatch, Nicola Fossati, Tobias Gross, Ann M Henry, Steven Joniau, Theo H van der Kwast, Vsevolod B Matveev, Henk G van der Poel, Maria De Santis, Ivo G Schoots, Thomas Wiegel, Cathy Yuhong Yuan, Philip Cornford, Nicolas Mottet, Thomas B Lam, Olivier Rouvière
CONTEXT: It remains unclear whether patients with a suspicion of prostate cancer (PCa) and negative multiparametric magnetic resonance imaging (mpMRI) can safely obviate prostate biopsy. OBJECTIVE: To systematically review the literature assessing the negative predictive value (NPV) of mpMRI in patients with a suspicion of PCa. EVIDENCE ACQUISITION: The Embase, Medline, and Cochrane databases were searched up to February 2016. Studies reporting prebiopsy mpMRI results using transrectal or transperineal biopsy as a reference standard were included...
March 20, 2017: European Urology
https://www.readbyqxmd.com/read/28333020/-18-f-choline-positron-emission-tomography-computed-tomography-and-multiparametric-magnetic-resonance-imaging-for-the-detection-of-early-local-recurrence-of-prostate-cancer-initially-treated-by-radiation-therapy-comparison-with-systematic-3-dimensional-transperineal
#4
Salim Kanoun, Paul Walker, Jean-Marc Vrigneaud, Edouard Depardon, Vincent Barbier, Olivier Humbert, Morgan Moulin, Gilles Créhange, Luc Cormier, Romaric Loffroy, François Brunotte, Alexandre Cochet
PURPOSE: To compare the diagnostic performance of (18)F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT), multiparametric prostate magnetic resonance imaging (mpMRI), and a combination of both techniques for the detection of local recurrence of prostate cancer initially treated by radiation therapy. METHODS AND MATERIALS: This was a retrospective, single-institution study of 32 patients with suspected prostate cancer recurrence who underwent both FCH-PET/CT and 3T mpMRI within 3 months of one another for the detection of recurrence...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28333017/effect-of-prostate-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-on-radiation-treatment-recommendations
#5
Aaron Reed, Luca F Valle, Uma Shankavaram, Andra Krauze, Aradhana Kaushal, Erica Schott, Theresa Cooley-Zgela, Bradford Wood, Peter Pinto, Peter Choyke, Baris Turkbey, Deborah E Citrin
PURPOSE: Targeted magnetic resonance imaging (MRI)/ultrasound fusion prostate biopsy (MRI-Bx) has recently been compared with the standard of care extended sextant ultrasound-guided prostate biopsy (SOC-Bx), with the former associated with an increased rate of detection of clinically significant prostate cancer. The present study sought to determine the influence of MRI-Bx on radiation therapy and androgen deprivation therapy (ADT) recommendations. METHODS AND MATERIALS: All patients who had received radiation treatment and had undergone SOC-Bx and MRI-Bx at our institution were included...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28330587/comparison-of-semi-automated-and-manual-methods-to-measure-the-volume-of-prostate-cancer-on-magnetic-resonance-imaging
#6
L Marin, M Ezziane, E Comperat, P Mozer, G Cancel-Tassin, J-F Coté, D Racoceanu, F Boudghene, O Lucidarme, O Cussenot, R Renard Penna
PURPOSE: The purpose of this study was to determine the accuracy of manual semi-automated and volumetric measurements to assess prostate cancer volume on multiparametric magnetic resonance imaging (MP-MRI) using whole-mount histopathology for validation. MATERIALS AND METHODS: We evaluated 30 consecutive men (median age, 65.7 years; interquartile range [IQR], 61.5-70.9 years) with a median prostatic specific antigen of 8.5ng/dL (IQR, 5.5-10.5ng/dL), who underwent MP-MRI before radical prostatectomy...
March 15, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28322902/negative-multi-parametric-mri-of-the-prostate-predicts-absence-of-clinically-significant-prostate-cancer-on-12-core-template-prostate-biopsy
#7
Amanda J Lu, Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, James Rosoff, Michael Spektor, Angelique Levi, Peter A Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
OBJECTIVE: To determine the negative predictive value of multiparametric-MRI (mpMRI), we evaluated the frequency of prostate cancer detection by 12-core template mapping biopsy in men whose mpMRI showed no suspicious regions. METHODS: 670 patients underwent mpMRI followed by transrectal ultrasound-(TRUS) guided systematic prostate biopsy from December 2012 to June 2016. Of this cohort, 100 patients had a negative mpMRI. mpMRI imaging sequences included T2-weighted, diffusion-weighted imaging, and dynamic contrast enhancement sequences...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28314291/biparametric-versus-multiparametric-mri-with-non-endorectal-coil-at-3t-in-the-detection-and-localization-of-prostate-cancer
#8
Michele Scialpi, Enrico Prosperi, Alfredo D'Andrea, Eugenio Martorana, Corrado Malaspina, Barbara Palumbo, Agostino Orlandi, Giuseppe Falcone, Michele Milizia, Luigi Mearini, Maria Cristina Aisa, Pietro Scialpi, Carlo DE Domincis, Giampaolo Bianchi, Angelo Sidoni
AIM: To assess the sensitivity of biparametric magnetic resonance imaging (bpMRI) with non-endorectal coil in the detection and localization of index (dominant) and non-index lesions in patients suspected of having prostate cancer. PATIENTS AND METHODS: We carried-out a retrospective analysis of multiparametric MRI (mpMRI) of 41 patients who underwent radical prostatectomy. Results of MRI for detection and localization of index and non-index lesions were correlated with those of histology...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28293720/pathologic-correlation-of-transperineal-in-bore-3-tesla-magnetic-resonance-imaging-guided-prostate-biopsy-samples-with-radical-prostatectomy-specimen
#9
Erik Velez, Andriy Fedorov, Kemal Tuncali, Olutayo Olubiyi, Christopher B Allard, Adam S Kibel, Clare M Tempany
PURPOSE: To determine the accuracy of in-bore transperineal 3-Tesla (T) magnetic resonance (MR) imaging-guided prostate biopsies for predicting final Gleason grades in patients who subsequently underwent radical prostatectomy (RP). METHODS: A retrospective review of men who underwent transperineal MR imaging-guided prostate biopsy (tpMRGB) with subsequent radical prostatectomy within 1 year was conducted from 2010 to 2015. All patients underwent a baseline 3-T multiparametric MRI (mpMRI) with endorectal coil and were selected for biopsy based on MR findings of a suspicious prostate lesion and high degree of clinical suspicion for cancer...
March 14, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28286063/motion-corrected-dwi-with-integrated-t2-mapping-for-simultaneous-estimation-of-adc-t2-relaxation-and-perfusion-in-prostate-cancer
#10
M Skorpil, P Brynolfsson, M Engström
OBJECTIVE: Multiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging - Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need...
March 9, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28279782/a-prospective-study-investigating-the-impact-of-multiparametric-mri-in-biopsy-na%C3%A3-ve-patients-with-clinically-suspected-prostate-cancer-the-prokomb-study
#11
Alexander D J Baur, Thomas Henkel, Manfred Johannsen, Thomas Speck, Lothar Weißbach, Bernd Hamm, Frank König
BACKGROUND: Patients with suspected prostate cancer (PCa) undergo systematic transrectal ultrasound (TRUS)-guided biopsy of the prostate in order to verify or rule out PCa. However, TRUS-guided biopsy is error-prone resulting in underdetection of clinically significant cancers as well as diagnosis of clinically insignificant cancers. Multiparametric MRI (mpMRI) might improve this diagnostic pathway and help to avoid unnecessary biopsies. DESIGN AND METHODS: The PROKOMB (Prostata - Kooperatives MRT-Projekt Berlin) study is a prospective two-arm multicentre study designed to evaluate the potential role of mpMRI as a triage test before biopsy...
March 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28267359/prostate-imaging-reporting-and-data-system-version-2-assessment-categories-and-pathologic-outcomes-in-patients-with-gleason-score-3-4-7-prostate-cancer-diagnosed-at-biopsy
#12
Christopher S Lim, Matthew D F McInnes, Trevor A Flood, Rodney H Breau, Christopher Morash, Rebecca E Thornhill, Nicola Schieda
OBJECTIVE: The purpose of this study is to assess associations between Prostate Imaging Reporting and Data System, version 2 (PI-RADSv2), categories and the presence of a tumor with a Gleason score (GS) of 4 + 3 = 7 or greater or the presence of extraprostatic extension (EPE) at radical prostatectomy (RP) in patients with a GS 3 + 4 = 7 tumor at biopsy. MATERIALS AND METHODS: A total of 81 men with GS 3 + 4 = 7 prostate cancer diagnosed by transrectal ultrasound-guided biopsy underwent multiparametric MRI and RP between 2012 and 2015...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28258961/-in-bore-mri-guided-prostate-biopsy-using-an-endorectal-nonmagnetic-device-a-prospective-study-of-70-consecutive-patients
#13
Riccardo Schiavina, Valerio Vagnoni, Daniele D'Agostino, Marco Borghesi, Antonio Salvaggio, Marco Giampaoli, Cristian V Pultrone, Giacomo Saraceni, Caterina Gaudiano, Mario Vigo, Lorenzo Bianchi, Hussam Dababneh, Gaetano La Manna, Francesco Chessa, Daniele Romagnoli, Giuseppe Martorana, Eugenio Brunocilla, Angelo Porreca
INTRODUCTION: We investigated the diagnostic performance of in-bore endorectal magnetic resonance imaging-guided biopsy (MRI-GB) with a 1.5-T MRI scanner using a 32-channel coil in patients with suspected prostate cancer (PCa). PATIENTS AND METHODS: Seventy patients with ≥ 1 suspicious area found on the preliminary multiparametric MRI scan were enrolled. The index lesion was defined as the lesion with the greatest Prostate Imaging Reporting and Data System, version 2 (PIRADS-v2), score...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28258784/results-of-targeted-biopsy-in-men-with-magnetic-resonance-imaging-lesions-classified-equivocal-likely-or-highly-likely-to-be-clinically-significant-prostate-cancer
#14
Wulphert Venderink, Annemarijke van Luijtelaar, Joyce G R Bomers, Marloes van der Leest, Christina Hulsbergen-van de Kaa, Jelle O Barentsz, J P Michiel Sedelaar, Jurgen J Fütterer
BACKGROUND: The Prostate Imaging Reporting and Data System (PI-RADS) is the most commonly used scoring system in prostate magnetic resonance imaging (MRI). One of the available techniques to target suspicious lesions is direct in-bore MRI-guided biopsy (MRGB). OBJECTIVE: To report on the experience and results of MRGB in a large cohort of patients with lesions classified as equivocal (PI-RADS 3), likely (PI-RADS 4), or highly likely (PI-RADS 5) to be clinically significant (cs) prostate cancer (PCa)...
February 28, 2017: European Urology
https://www.readbyqxmd.com/read/28246496/1-5-tesla-multiparametric-magnetic-resonance-imaging-for-the-detection-of-clinically-significant-prostate-cancer
#15
Cristian Popita, Anca Raluca Popita, Adela Sitar-Taut, Bogdan Petrut, Bogdan Fetica, Ioan Coman
BACKGROUND AND AIM: Multiparametric-magnetic resonance imaging (mp-MRI) is the main imaging modality used for prostate cancer detection. The aim of this study is to evaluate the diagnostic performance of mp-MRI at 1.5-Tesla (1.5-T) for the detection of clinically significant prostate cancer. METHODS: In this ethical board approved prospective study, 39 patients with suspected prostate cancer were included. Patients with a history of positive prostate biopsy and patients treated for prostate cancer were excluded...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#16
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28237429/prostate-mri-for-brachytherapists-anatomy-and-technique
#17
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
PURPOSE: To present an overview of mp MRI techniques necessary for high-resolution imaging of prostate. METHODS: We summarize examples from our clinical experience and concepts from the current literature that illustrate normal prostate anatomy on multiparametric MRI (mp MRI). RESULTS: Our experience regarding optimal mp MRI image acquisition is provided, as well as a summary of prostate and periprostatic anatomy and anatomical variants that pose challenges for BT...
February 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28236452/multiparametric-magnetic-resonance-imaging-and-prostate-cancer-what-s-new
#18
V Catalá, J C Vilanova, J M Gaya, F Algaba, T Martí
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to present an updated revision of technical aspects, reading patterns and prostatic MP-MRI in Pca, with a multidisciplinary approach. Currently guidelines establish the use of the MP-MRI when there is a high PSA and a negative prostatic biopsy; tumor staging; evaluation in candidates to active surveillance; focal treatments plans and tumoral recurrence evaluation...
February 21, 2017: Radiología
https://www.readbyqxmd.com/read/28236334/pi-radsv2-how-we-do-it
#19
Matthew D Greer, Peter L Choyke, Baris Turkbey
Much criticism has been leveled at screening for prostate cancer using prostate-specific antigen (PSA) testing, yet there is no suitable replacement to improve the detection of clinically significant cancer (CSC). Prostate multiparametric magnetic resonance imaging (mpMRI) combined with mpMRI-guided biopsies is one possible solution, as it reduces detection of low-grade disease and increases detection of CSC. However, mpMRI is critically limited by lack of standardization across institutions and low interobserver agreement...
February 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#20
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
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