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Multiparametric imaging

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https://www.readbyqxmd.com/read/28099112/science-to-practice-multiparametric-molecular-and-functional-us-imaging-goes-three-dimensional
#1
Fabian Kiessling
Although microbubbles can boost the diagnostic value of ultrasonography (US), they are not routinely applied in clinical tumor diagnosis. This can be explained by the limited reproducibility of US examinations and the fact that single or few recorded image sections may not be representative of the entire tumor. Three-dimensional (3D) US may help to overcome these limitations. Therefore, Wang and coworkers applied a 3D matrix transducer to monitor response of colon cancer xenografts to antiangiogenic therapy with functional and molecular US imaging...
February 2017: Radiology
https://www.readbyqxmd.com/read/28096922/relationship-between-gleason-score-and-apparent-diffusion-coefficients-of-diffusion-weighted-magnetic-resonance-imaging-in-prostate-cancer-patients
#2
Tae Heon Kim, Chan Kyo Kim, Byung Kwan Park, Hwang Gyun Jeon, Byung Chang Jeong, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Seong Soo Jeon
INTRODUCTION: We assessed the correlation between the apparent diffusion coefficient (ADC) and pathological Gleason score (GS) of prostate cancer patients. METHODS: A total of 125 patients who underwent multiparametric magnetic resonance imaging before radical prostatectomy for prostate cancer were included in this study. ADC values were compared with different GS. We used receiver operating characteristic analysis and determined the ADC cutoff value to differentiate tumours with a GS of 6 from those with a GS ≥7...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28094088/usefulness-of-multiparametric-computerized-tomography-findings-in-the-differential-diagnosis-of-stroke-mimics-of-epileptic-origin-a-preliminary-study
#3
R López Ruiz, S Quintas, P Largo, M de Toledo, M T Carreras, A Gago-Veiga, R Manzanares, J Vivancos
OBJECTIVE: Thirty percent of the patients for whom code stroke is activated have stroke mimics, the most common being epilepsy. Our purpose was to evaluate the usefulness of multiparametric CT for differentiating between seizure-related symptoms and vascular events. MATERIAL AND METHODS: We conducted a retrospective observational study; data were gathered prospectively during one year. We studied multiparametric CT images of patients admitted following code stroke activation and finally diagnosed with epilepsy...
January 13, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28094057/multiparametric-magnetic-resonance-imaging-targeted-biopsy-for-early-detection-of-prostate-cancer-all-that-glitters-is-not-gold
#4
EDITORIAL
Gianluca Giannarini, Alessandro Crestani, Marta Rossanese, Vincenzo Ficarra
No abstract text is available yet for this article.
January 13, 2017: European Urology
https://www.readbyqxmd.com/read/28089429/diagnosis-and-quantification-of-fibrosis-steatosis-and-hepatic-siderosis-through-multiparametric-magnetic-resonance-imaging
#5
M Stoopen-Rometti, E R Encinas-Escobar, C R Ramirez-Carmona, E Wolpert-Barraza, E Kimura-Hayama, L A Sosa-Lozano, R Favila, Y Kimura-Fujikami, J A Saavedra-Abril, A Loaeza-Del Castillo
BACKGROUND: The presence of liver fibrosis is the common denominator in numerous chronic liver diseases that can progress to fibrosis and hepatocellular carcinoma. Most important, with respect to frequency, are viral hepatitis and non-alcoholic fatty liver disease, the prevalence of which is increasing in epidemic proportions. Liver biopsy, albeit imperfect, continues to be the criterion standard, but in many clinical situations tends to be replaced with noninvasive imaging methods. OBJECTIVES: The aim of the present article was to describe our imaging department experience with magnetic resonance elastography and to analyze and discuss recently published results in gastroenterology, hepatology, and radiology from other authors in the literature, complemented with a PubMed search covering the last 10 years...
January 12, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28087898/editorial-comment-to-assessing-clinically-significant-prostate-cancer-diagnostic-properties-of-multiparametric-magnetic-resonance-imaging-compared-to-three-dimensional-transperineal-template-mapping-histopathology
#6
Claudia Kesch, Boris A Hadaschik, Jan P Radtke
No abstract text is available yet for this article.
January 13, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28075651/imaging-characteristics-of-prostate-cancer-patients-who-discontinued-active-surveillance-on-3-t-multiparametric-prostate-mri
#7
David J Habibian, Corinne C Liu, Alex Dao, Kaitlin E Kosinski, Aaron E Katz
OBJECTIVE: Early-stage prostate cancer may be followed with active surveillance to avoid overtreatment. Our institution's active surveillance regimen uses annual MRI in place of serial biopsies, and biopsies are performed only when clinically necessary. The objective of our study was to report the multiparametric MRI characteristics of prostate cancer patients who discontinued active surveillance at our institution after repeat imaging revealed possible evidence of tumor upgrading. MATERIALS AND METHODS: The Department of Urology at Winthrop University Hospital prospectively maintains a database of prostate cancer patients who are monitored with active surveillance...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28065575/multiparametric-analysis-of-cell-shape-demonstrates-that-%C3%AE-pix-directly-couples-yap-activation-to-extracellular-matrix-adhesion
#8
Julia E Sero, Chris Bakal
Mechanical signals from the extracellular matrix (ECM) and cellular geometry regulate the nuclear translocation of transcriptional regulators such as Yes-associated protein (YAP). Elucidating how physical signals control the activity of mechanosensitive proteins poses a technical challenge, because perturbations that affect cell shape may also affect protein localization indirectly. Here, we present an approach that mitigates confounding effects of cell-shape changes, allowing us to identify direct regulators of YAP localization...
January 2, 2017: Cell Systems
https://www.readbyqxmd.com/read/28048357/su-f-r-05-multidimensional-imaging-radiomics-geodesics-a-novel-manifold-learning-based-automatic-feature-extraction-method-for-diagnostic-prediction-in-multiparametric-imaging
#9
V Parekh, M A Jacobs
PURPOSE: Multiparametric radiological imaging is used for diagnosis in patients. Potentially extracting useful features specific to a patient's pathology would be crucial step towards personalized medicine and assessing treatment options. In order to automatically extract features directly from multiparametric radiological imaging datasets, we developed an advanced unsupervised machine learning algorithm called the multidimensional imaging radiomics-geodesics(MIRaGe). METHODS: Seventy-six breast tumor patients underwent 3T MRI breast imaging were used for this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048193/mo-d-pins-room-hall-e-02-multiparametric-fuctional-imaging-in-radiation-therapy
#10
Y Cao
MRI, with its excellent soft tissue contrast and its ability to provide physiological as well as anatomical information, is becoming increasingly used in radiation therapy for treatment planning, image-guided radiation therapy, and treatment evaluation. This session will explore solutions to integrating MRI into the simulation process. Obstacles for using MRI for simulation include distortions and artifacts, image acquisition speed, complexity of imaging techniques, and lack of electron density information...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047934/tu-d-207b-04-identifying-high-risk-tumor-volume-based-on-multi-region-and-integrated-analysis-of-multi-parametric-mr-images-for-prognostication-of-glioblastoma
#11
X Ren, Y Cui, H Gao, R Li
PURPOSE: To identify high-risk tumor volume for predicting survival in patients with glioblastoma on the basis of multi-region and integrated analysis of multi-parametric MR images. METHODS: In this retrospectively study, 34 patients with glioblastoma from the Cancer Imaging Archive (TCIA) were analyzed. The patients were included if all of the pre-operative 1) T1-weighted contrast-enhanced (T1c), 2) T2-weighted fluid-attenuation inversion recovery (FLAIR), and 3) diffusion-weighted (DW) MR images were available...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047097/we-fg-206-09-association-of-prostate-volumes-with-restricted-diffusion-and-prostate-cancer-aggressiveness
#12
Y Tschudi
PURPOSE: To create an automatic workflow for evaluation of thresholds of restricted diffusion, based on Apparent Diffusion Coefficient (ADC) values in multiparametric (mp)MRI of the prostate. To investigate the association of these volumes with biopsy Gleason Score (GS). METHODS: Patients with prostate cancer, imaged on 3T Discovery MR750 (GE, Waukesha, WI) magnet were selected from departmental database based on the presence of mpMRI exam. All subsequent analyses were performed using Java plugins in MIM (MIM, Cleveland, Ohio)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046902/su-d-207a-03-potential-role-of-bold-mri-in-discrimination-of-aggressive-tumor-habitat-in-prostate-cancer
#13
J Ford, C Lopez, Y Tschudi, A Breto, K Padgett, A Pollack, R Stoyanova
PURPOSE: To determine whether blood oxygenation level dependent (BOLD) MRI signal measured in prostate cancer patients, in addition to quantitative diffusion and perfusion parameters from multiparametric (mp)MRI exams, can help discriminate aggressive and/or radioresistant lesions. METHODS: Several ongoing clinical trials in our institution require mpMRI exam to determine eligibility (presence of identifiable tumor lesion on mpMRI) and prostate volumes for dose escalation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042334/visualization-quantification-and-characterization-of-caerulein-induced-acute-pancreatitis-in-rats-by-3-0t-clinical-mri-biochemistry-and-histomorphology
#14
Ting Yin, Ronald Peeters, Yewei Liu, Yuanbo Feng, Xinyuan Zhang, Yansheng Jiang, Jie Yu, Steven Dymarkowski, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
Purpose: To investigate whether Caerulein-induced acute pancreatitis (AP) in rats could be noninvasively studied by clinical magnetic resonance imaging (MRI) techniques and validated by enzymatic biochemistry and histomorphology. Materials and Methods: The study was approved by the institutional animal ethical committee. The AP was induced in 26 rats by intraperitoneal injections of Caerulein, as compared to 6 normal rats. T2-weighted 3D MRI, T2 relaxation measurement and contrast enhanced T1-weighted MRI were performed at 3 Tesla...
2017: Theranostics
https://www.readbyqxmd.com/read/28031053/serum-biomarkers-and-changes-in-clinical-mri-evidence-of-golimumab-treated-patients-with-ankylosing-spondylitis-results-of-the-randomized-placebo-controlled-go-raise-study
#15
Robert D Inman, Xenofon Baraliakos, Kay-Geert A Hermann, Jürgen Braun, Atul Deodhar, Désirée van der Heijde, Stephen Xu, Benjamin Hsu
BACKGROUND: In the present study, we evaluated relationships between serum biomarkers and clinical/magnetic resonance imaging (MRI) findings in golimumab-treated patients with ankylosing spondylitis. METHODS: In the GO-RAISE study, 356 patients with ankylosing spondylitis randomly received either placebo (n = 78) or golimumab 50 mg or 100 mg (n = 278) injections every 4 weeks through week 24 (placebo-controlled); patients continuing GO-RAISE received golimumab through week 252...
December 28, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28017389/la-strain-categorization-of-lv-diastolic%C3%A2-dysfunction
#16
Amita Singh, Karima Addetia, Francesco Maffessanti, Victor Mor-Avi, Roberto M Lang
OBJECTIVES: This study sought to observe the relationship between left atrial (LA) strain and left ventricular diastolic function and determine whether LA strain could be used to detect diastolic dysfunction (DD) and classify its degree when present. BACKGROUND: The assessment of diastolic function is complex and multiparametric because most conventional parameters do not follow the progression of DD. Strain imaging is an emerging index of LA function, with recent data demonstrating that LA strain is diminished in diastolic heart failure...
December 8, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28012730/magnetic-resonance-imaging-of-the-prostate-interpretation-using-the-pi-rads-v2
#17
A Torregrosa Andrés, M Otero García, M Sineiro Galiñanes
OBJECTIVE: Version 2 of the Prostate Imaging and Reporting and Data System (PI-RADS) was developed to help in the detection, location, and characterization of prostate cancer with magnetic resonance imaging (MRI). Its recommendations for standardizing image acquisition parameters aims to reduce variability in the interpretation of MRI studies of the prostate; this approach, together with structured reporting, has the added value of improving communication among radiologists and between radiologists and urologists...
December 21, 2016: Radiología
https://www.readbyqxmd.com/read/28012728/magnetic-resonance-imaging-in-the-new-paradigm-for-the-diagnosis-of-prostate-cancer
#18
J C Vilanova, V Catalá
For various reasons, prostate cancer is a major public health problem. It is a very common cancer, but has a very low mortality rate because it comprises two types of disease: one insignificant, indolent, and much more common, and the other aggressive, significant, and much less common. The routine diagnostic approach to prostate cancer has been systematic blind biopsies, which has low detection rates and might detect low risk, insignificant prostate cancer, leading to overdiagnosis and overtreatment of indolent cancers...
December 21, 2016: Radiología
https://www.readbyqxmd.com/read/28004162/multiparametric-dynamic-contrast-enhanced-ultrasound-imaging-of-prostate-cancer
#19
Rogier R Wildeboer, Arnoud W Postema, Libertario Demi, Maarten P J Kuenen, Hessel Wijkstra, Massimo Mischi
OBJECTIVES: The aim of this study is to improve the accuracy of dynamic contrast-enhanced ultrasound (DCE-US) for prostate cancer (PCa) localization by means of a multiparametric approach. MATERIALS AND METHODS: Thirteen different parameters related to either perfusion or dispersion were extracted pixel-by-pixel from 45 DCE-US recordings in 19 patients referred for radical prostatectomy. Multiparametric maps were retrospectively produced using a Gaussian mixture model algorithm...
December 21, 2016: European Radiology
https://www.readbyqxmd.com/read/28002239/feasibility-of-multiparametric-magnetic-resonance-imaging-of-the-prostate-at-7-t
#20
Miriam W Lagemaat, Bart W J Philips, Eline K Vos, Mark J van Uden, Jurgen J Fütterer, Sjoerd F Jenniskens, Tom W J Scheenen, Marnix C Maas
OBJECTIVES: The aim of this study was to evaluate the technical feasibility of prostate multiparametric magnetic resonance imaging (mpMRI) at a magnetic field strength of 7 T. MATERIALS AND METHODS: In this prospective institutional review board-approved study, 14 patients with biopsy-proven prostate cancer (mean age, 65.2 years; median prostate-specific antigen [PSA], 6.2 ng/mL), all providing signed informed consent, underwent 7 T mpMRI with an external 8-channel body-array transmit coil and an endorectal receive coil between September 2013 and October 2014...
December 20, 2016: Investigative Radiology
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