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Multiparametric imaging

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https://www.readbyqxmd.com/read/28921850/prospective-comparison-of-transperineal-mri-ultrasound-fusion-biopsy-and-transrectal-systematic-biopsy-in-biopsy-na%C3%A3-ve-patients
#1
Angelika Borkowetz, Boris Hadaschik, Ivan Platzek, Marieta Toma, Georgi Torsev, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo Baretton, Jan Philipp Radtke, Claudia Kesch, Markus Hohenfellner, Michael Froehner, Heinz-Peter Schlemmer, Manfred Wirth, Stefan Zastrow
OBJECTIVES: To evaluate the value of multiparametric magnetic resonance imaging (mpMRI) for the detection of significant prostate cancer (PCa) and to compare transperineal MRI/ultrasound-fusion biopsy (fusPbx) to conventional transrectal systematic biopsy (sysPbx) in biopsy-naïve patients. PATIENTS AND METHODS: This multicentre, prospective trial investigated biopsy-naïve patients with suspicion of PCa undergoing transperineal fusPbx in combination with transrectal sysPbx (comPbx)...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28910821/vascular-disrupting-agent-in-pancreatic-and-hepatic-tumour-allografts-observations-of-location-dependent-efficacy-by-mri-microangiography-and-histomorphology
#2
Ting Yin, Yewei Liu, Ronald Peeters, Yuanbo Feng, Jie Yu, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
BACKGROUND: Tumours growing in organs of different vascular environment could exhibit diverse responses to vascular disrupting agent (VDA). This study was aimed to identify in vivo imaging biomarkers for evaluation of pancreatic and hepatic tumours and comparison of their responses to a VDA Combretastatin A4 Phosphate (CA4P) using multiparametric MRI. METHODS: Male WAG/Rij rats were used for orthotopic pancreatic head tumour and hepatic tumour implantation; tumour growth was monitored by 3D isotropic MRI using a 3...
September 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28906339/multiparametric-magnetic-resonance-imaging-of-prostate-cancer-bone-disease-correlation-with-bone-biopsy-histological-and-molecular-features
#3
Raquel Perez-Lopez, Daniel Nava Rodrigues, Ines Figueiredo, Joaquin Mateo, David J Collins, Dow-Mu Koh, Johann S de Bono, Nina Tunariu
OBJECTIVES: The aim of this study was to correlate magnetic resonance imaging (MRI) of castration-resistant prostate cancer (CRPC) bone metastases with histological and molecular features of bone metastases. MATERIALS AND METHODS: Forty-three bone marrow biopsies from 33 metastatic CRPC (mCRPC) patients with multiparametric MRI and documented bone metastases were evaluated. A second cohort included 10 CRPC patients with no bone metastases. Associations of apparent diffusion coefficient (ADC), normalized b900 diffusion-weighted imaging (nDWI) signal, and signal-weighted fat fraction (swFF) with bone marrow biopsy histological parameters were evaluated using Mann-Whitney U test and Spearman correlations...
September 12, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28887398/-64-cucl2-pet-ct-in-prostate-cancer-relapse
#4
Arnoldo Piccardo, Francesco Paparo, Matteo Puntoni, Sergio Righi, Gianluca Bottoni, Lorenzo Bacigalupo, Silvia Zanardi, Andrea DeCensi, Giulia Ferrarazzo, Monica Gambaro, Filippo Grillo Ruggieri, Fabio Campodonico, Laura Tomasello, Luca Timossi, Simona Sola, Egesta Lopci, Manlio Cabria
To evaluate the biodistribution, kinetics and radiation dosimetry of (64)CuCl2 in humans and to assess the ability of (64)CuCl2-PoPET/CT to detect prostate cancer (PCa) recurrence in patients with biochemical relapse. Methods: we prospectively evaluated 50 PCa patients with biochemical relapse after surgery or external-beam radiation therapy. All patients underwent (64)CuCl2-PET/CT, (18)F-Choline-PET/CT and multiparametric magnetic resonance imaging (mpMRI) within 15 days of each other. Experienced readers interpreted the images, and the detection rate (DR) of each imaging modality was calculated...
September 8, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28884957/long-term-sequelae-of-hippocampal-lesions-in-patients-with-transient-global-amnesia-a-multiparametric-mri-study
#5
Xiaochuan Wang, Ran Zhang, Wenping Wei, Haibo Jiang, Zhongming Gao, Jianzhong Lin, Jiaxing Zhang
BACKGROUND: MRI signal diffusion-weighted imaging (DWI) hyperintensity in the hippocampus in patients with transient global amnesia (TGA) are resolved within several days after the onset of TGA. PURPOSE: To use multiparametric MRI to unravel the sequelae of TGA. STUDY TYPE: A prospective longitudinal study. POPULATION: Eight TGA patients. FIELD STRENGTH/SEQUENCE: A 3.0T Siemens Tim Trio MRI scanner with T1 -weighted MPRAGE, diffusion-weighted echo planar imaging, and multiecho gradient-recalled echo sequences...
September 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28872226/prebiopsy-multiparametric-mri-based-risk-score-for-predicting-prostate-cancer-in-biopsy-naive-men-with-prostate-specific-antigen-between-4-10%C3%A2-ng-ml
#6
Durgesh Kumar Dwivedi, Rajeev Kumar, Alok Kumar Dwivedi, Girdhar S Bora, Sanjay Thulkar, Sanjay Sharma, Siddhartha Datta Gupta, Naranamangalam R Jagannathan
BACKGROUND: Risk calculators have traditionally utilized serum prostate-specific antigen (PSA) values in addition to clinical variables to predict the likelihood of prostate cancer (PCa). PURPOSE: To develop a prebiopsy multiparametric MRI (mpMRI)-based risk score (RS) and a statistical equation for predicting the risk of PCa in biopsy-naive men with serum PSA between 4-10 ng/mL that may help reduce unnecessary biopsies. STUDY TYPE: Prospective cross-sectional study...
September 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28868256/multiparametric-mri-and-18-f-fluorodeoxyglucose-positron-emission-tomography-imaging-is-a-potential-prognostic-imaging-biomarker-in-recurrent-glioblastoma
#7
Comron Hassanzadeh, Yuan James Rao, Anupama Chundury, Jackson Rowe, Maria Rosana Ponisio, Akash Sharma, Michelle Miller-Thomas, Christina I Tsien, Joseph E Ippolito
PURPOSE/OBJECTIVES: Multiparametric advanced MR and [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging may be important biomarkers for prognosis as well for distinguishing recurrent glioblastoma multiforme (GBM) from treatment-related changes. METHODS/MATERIALS: We retrospectively evaluated 30 patients treated with chemoradiation for GBM and underwent advanced MR and FDG-PET for confirmation of tumor progression. Multiparametric MRI and FDG-PET imaging metrics were evaluated for their association with 6-month overall (OS) and progression-free survival (PFS) based on pathological, radiographic, and clinical criteria...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28867582/-pathological-findings-of-visible-and-non-visible-tumors-on-multiparametric-magnetic-resonance-imaging-mri-prior-to-radical-prostatectomy
#8
A Rivière, F Cornud, F Beuvon, M Sibony, P Legmann, N Barry Delongchamps
INTRODUCTION: As urologists are questioned about the overtreatment of localized prostate cancer, multiparametric MRI can diagnose significant prostate cancer thanks to targeted biopsies. However, some tumors cannot be detected by MRI. What are the pathological characteristics of those tumors? MATERIALS AND METHODS: We have selected 144 consecutive patients treated with radical prostatectomy for clinically localized prostate cancer diagnosed on systematic and targeted biopsies (Koelis(®)) according to multiparametric MRI findings...
August 31, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28866023/where-do-trus-and-mri-guided-biopsies-miss-significant-prostate-cancer
#9
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Ingegerd Balslev, Henrik S Thomsen
OBJECTIVE: To identify the location of missed sPCa lesions by transrectal ultrasound-guided (TRUSbx) and multiparametric MRI-guided biopsies (mpMRIbx) in men undergoing repeat biopsies. METHODS: 289 men with prior negative TRUSbx underwent mpMRI. The location of any suspicious lesion was registered and scored using PIRADS v1 classification according to the likelihood of being sPCa. All patients underwent repeat (re-)TRUSbx and targeted mpMRIbx (image fusion) of any suspicious lesion...
August 30, 2017: Urology
https://www.readbyqxmd.com/read/28864615/prostate-specific-membrane-antigen-ligands-for-imaging-and-therapy
#10
Matthias Eiber, Wolfgang P Fendler, Steven P Rowe, Jeremie Calais, Michael S Hofman, Tobias Maurer, Sarah M Schwarzenboeck, Clemens Kratowchil, Ken Herrmann, Frederik L Giesel
The prostate-specific membrane antigen (PSMA) is highly expressed on most prostate cancer (PC) cells. Therefore, the targeting of PSMA has become increasingly important over the last decade. Glu-urea-based PSMA ligands used for both imaging and radioligand therapy are the mainstays of the current success. For PET imaging, both (68)Ga- and (18)F-labeled agents have been successfully translated to clinical applications. Mainly retrospective cohort studies have shown a high value in the setting of biochemical recurrence, with high detection rates even in the presence of low prostate-specific antigen levels...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28863715/measurement-of-the-velocity-of-neutral-fragments-by-the-correlated-ion-and-neutral-time-of-flight-method-combined-with-velocity-map-imaging
#11
F Berthias, L Feketeová, R Della Negra, T Dupasquier, R Fillol, H Abdoul-Carime, B Farizon, M Farizon, T D Märk
In the challenging field of imaging molecular dynamics, a novel method has been developed and implemented that allows the measurement of the velocity of neutral fragments produced in collision induced dissociation experiments on an event-by-event basis. This has been made possible by combining a correlated ion and neutral time of flight method with a velocity map imaging technique. This new method relies on a multiparametric correlated detection of the neutral and charged fragments from collision induced dissociation on one single detector...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28862352/geometric-distortion-correction-in-prostate-diffusion-weighted-mri-and-its-effect-on-quantitative-apparent-diffusion-coefficient-analysis
#12
Gabriel Nketiah, Kirsten M Selnaes, Elise Sandsmark, Jose R Teruel, Brage Krüger-Stokke, Helena Bertilsson, Tone F Bathen, Mattijs Elschot
PURPOSE: To evaluate the effect of correction for B0 inhomogeneity-induced geometric distortion in echo-planar diffusion-weighted imaging on quantitative apparent diffusion coefficient (ADC) analysis in multiparametric prostate MRI. METHODS: Geometric distortion correction was performed in echo-planar diffusion-weighted images (b = 0, 50, 400, 800 s/mm(2) ) of 28 patients, using two B0 scans with opposing phase-encoding polarities. Histology-matched tumor and healthy tissue volumes of interest delineated on T2 -weighted images were mapped to the nondistortion-corrected and distortion-corrected data sets by resampling with and without spatial coregistration...
September 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28861291/score-3-prostate-lesions-a-gray-zone-for-pi-rads-v2
#13
REVIEW
Michele Scialpi, Eugenio Martorana, Maria Cristina Aisa, Valeria Rondoni, Alfredo D'Andrea, Giampaolo Bianchi
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) does not offer a precise guidance on the clinical management (biopsy or not biopsy) for PI-RADS v2 score 3 lesions. Lesion volume calculated on biparametric MRI (bpMRI) [T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI)] by introducing a cut-off of 0.5 mL, allows to distinguish the lesions assigned by the multiparametric MRI (mpMRI) to the category PI-RADS v2 score 3 in two subgroups: a) Indolent or low risk lesions with volume <0...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28860608/fmiso-pet-derived-brain-oxygen-tension-maps-application-to-glioblastoma-and-less-aggressive-gliomas
#14
Ararat Chakhoyan, Jean-Sebastien Guillamo, Solène Collet, François Kauffmann, Nicolas Delcroix, Emmanuèle Lechapt-Zalcman, Jean-Marc Constans, Edwige Petit, Eric T MacKenzie, Louisa Barré, Myriam Bernaudin, Omar Touzani, Samuel Valable
Quantitative imaging modalities for the analysis of hypoxia in brain tumors are lacking. The objective of this study was to generate absolute maps of tissue ptO2 from [(18)F]-FMISO images in glioblastoma and less aggressive glioma patients in order to quantitatively assess tumor hypoxia. An ancillary objective was to compare estimated ptO2 values to other biomarkers: perfusion weighted imaging (PWI) and tumor metabolism obtained from (1)H-MR mono-voxel spectroscopy (MRS). Ten patients with glioblastoma (GBM) and three patients with less aggressive glioma (nGBM) were enrolled...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856386/-focal-therapy-of-prostate-cancer
#15
R Ganzer, T Franiel, J Köllermann, T Kuru, D Baumunk, A Blana, B Hadaschik, J von Hardenberg, T Henkel, K-U Köhrmann, U-B Liehr, S Machtens, A Roosen, G Salomon, H-P Schlemmer, L Sentker, J Wendler, U Witzsch, M Schostak
The target of focal therapy (FT) in prostate cancer (PC) is partial treatment of the prostate aiming at preserving surrounding anatomical structures. The intention is to minimize typical side effects of radical treatment options combined with local tumor control. Numerous established and new technologies are used. Results of published studies showed a good safety profile, few side effects and good preservation of functional results. Oncologic long-term data are lacking so far. Photodynamic therapy (PDT) is the only technology that has been studied in a published prospective randomized trial...
August 30, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28855627/induced-pluripotent-stem-cell-derived-neural-stem-cell-therapy-enhances-recovery-in-an-ischemic-stroke-pig-model
#16
Emily W Baker, Simon R Platt, Vivian W Lau, Harrison E Grace, Shannon P Holmes, Liya Wang, Kylee Jo Duberstein, Elizabeth W Howerth, Holly A Kinder, Steve L Stice, David C Hess, Hui Mao, Franklin D West
Induced pluripotent stem cell-derived neural stem cells (iNSCs) have significant potential as an autologous, multifunctional cell therapy for stroke, which is the primary cause of long term disability in the United States and the second leading cause of death worldwide. Here we show that iNSC transplantation improves recovery through neuroprotective, regenerative, and cell replacement mechanisms in a novel ischemic pig stroke model. Longitudinal multiparametric magnetic resonance imaging (MRI) following iNSC therapy demonstrated reduced changes in white matter integrity, cerebral blood perfusion, and brain metabolism in the infarcted tissue...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28853167/a-urinary-biomarker-based-risk-score-correlates-with-multiparametric-mri-for-prostate-cancer-detection
#17
Rianne J Hendriks, Marloes M G van der Leest, Siebren Dijkstra, Jelle O Barentsz, Wim Van Criekinge, Christina A Hulsbergen-van de Kaa, Jack A Schalken, Peter F A Mulders, Inge M van Oort
BACKGROUND: Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non-invasive techniques for the detection of clinically significant disease, leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the association between a novel urinary biomarker-based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection. METHODS: This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies...
August 29, 2017: Prostate
https://www.readbyqxmd.com/read/28852490/the-importance-of-accurate-measurement-of-aortic-stiffness-in-patients-with-chronic-kidney-disease-and-end-stage-renal-disease
#18
Sherna F Adenwalla, Matthew P M Graham-Brown, Francesca M T Leone, James O Burton, Gerry P McCann
Cardiovascular (CV) disease is the leading cause of death in chronic kidney disease (CKD) and end-stage renal disease (ESRD). A key driver in this pathology is increased aortic stiffness, which is a strong, independent predictor of CV mortality in this population. Aortic stiffening is a potentially modifiable biomarker of CV dysfunction and in risk stratification for patients with CKD and ESRD. Previous work has suggested that therapeutic modification of aortic stiffness may ameliorate CV mortality. Nevertheless, future clinical implementation relies on the ability to accurately and reliably quantify stiffness in renal disease...
August 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28844612/percutaneous-image-guided-biopsies-of-small-renal-tumors-current-practice-and-perspectives
#19
REVIEW
C Marcelin, D Ambrosetti, J C Bernhard, C Roy, N Grenier, F H Cornelis
Percutaneous image-guided biopsies help better select patients with renal tumors smaller than 4cm. These biopsies are performed to reduce the risks of overtreatment and to discriminate between patients who need ablation therapy and those who require active surveillance. Percutaneous image-guided biopsies are effective for a definitive diagnosis with little risk of complications when cautions are observed. With the current addition of multiparametric imaging, standardized biopsy protocols may further help adapt therapeutic decisions...
September 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28837356/phenotypic-assays-for-characterizing-compound-effects-on-induced-pluripotent-stem-cell-derived-cardiac-spheroids
#20
Oksana Sirenko, Michael K Hancock, Carole Crittenden, Matthew Hammer, Sean Keating, Coby B Carlson, Grischa Chandy
Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a major challenge in drug discovery. The focus of this study was to establish high-throughput compatible three-dimensional (3D) cardiotoxicity assays using human induced pluripotent stem cell-derived cardiomyocytes. Using both high-content imaging and fast kinetic fluorescence imaging, the impact of various compounds on the beating rates and patterns of cardiac spheroids was monitored by changes in intracellular Ca(2+) levels with calcium-sensitive dyes...
August 2017: Assay and Drug Development Technologies
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