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Multiparametric imaging

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https://www.readbyqxmd.com/read/28515009/transfer-learning-on-fused-multiparametric-mr-images-for-classifying-histopathological-subtypes-of-rhabdomyosarcoma
#1
Imon Banerjee, Alexis Crawley, Mythili Bhethanabotla, Heike E Daldrup-Link, Daniel L Rubin
This paper presents a deep-learning-based CADx for the differential diagnosis of embryonal (ERMS) and alveolar (ARMS) subtypes of rhabdomysarcoma (RMS) solely by analyzing multiparametric MR images. We formulated an automated pipeline that creates a comprehensive representation of tumor by performing a fusion of diffusion-weighted MR scans (DWI) and gadolinium chelate-enhanced T1-weighted MR scans (MRI). Finally, we adapted transfer learning approach where a pre-trained deep convolutional neural network has been fine-tuned based on the fused images for performing classification of the two RMS subtypes...
May 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28514203/cost-effectiveness-of-mr-imaging-guided-strategies-for-detection-of-prostate-cancer-in-biopsy-naive-men
#2
Shivani Pahwa, Nicholas K Schiltz, Lee E Ponsky, Ziang Lu, Mark A Griswold, Vikas Gulani
Purpose To evaluate the cost-effectiveness of multiparametric diagnostic magnetic resonance (MR) imaging examination followed by MR imaging-guided biopsy strategies in the detection of prostate cancer in biopsy-naive men presenting with clinical suspicion of cancer for the first time. Materials and Methods A decision-analysis model was created for biopsy-naive men who had been recommended for prostate biopsy on the basis of abnormal digital rectal examination results or elevated prostate-specific antigen levels (age groups: 41-50 years, 51-60 years, and 61-70 years)...
May 17, 2017: Radiology
https://www.readbyqxmd.com/read/28513296/confirmatory-biopsy-of-men-under-active-surveillance-extended-versus-saturation-versus-multiparametric-magnetic-resonance-imaging-transrectal-ultrasound-fusion-prostate-biopsy
#3
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Pennisi, Giuseppe Morgia
OBJECTIVE: The aim of this study was to evaluate the detection rate for clinically significant prostate cancer (PCa) after multiparametric magnetic resonance imaging (mpMRI)/transrectal ultrasound (TRUS) fusion biopsy versus extended biopsy or saturation prostate biopsy (SPBx) in men enrolled on active surveillance (AS). MATERIALS AND METHODS: From May 2013 to January 2016, 100 men with very low-risk PCa were enrolled on AS. Eligible criteria were: life expectancy greater than 10 years, cT1c, prostate-specific antigen (PSA) below 10 ng/ml, PSA density less than 0...
May 17, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28511220/-significance-and-value-of-psma-ligands-in-prostate-cancer
#4
Claudia Gasch, Stefan Körber, Christophe Kremer, Matthias Eiber, Clemens Kratochwil, Uwe Haberkorn, Markus Hohenfellner, Boris Hadaschik, Frederik L Giesel
In recent years, PSMA-targeting PET tracers such as (68)Ga-PSMA-11 have shown promising results, thus contributing to a better management of prostate cancer patients. At the present time, (68)Ga-PSMA-11 is most frequently used for diagnostic evaluation in the setting of biochemical recurrence of prostate cancer. In this context, the (68)Ga-PSMA-11 PET/CT delivers superior detection rates compared to conventional imaging, especially for the detection of small, unsuspicious lesions or lesions in the presence of low PSA values...
April 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28507455/neoadjuvant-chemoradiotherapy-of-the-rectal-carcinoma-the-correlation-between-the-findings-on-the-restaging-multiparametric-3t-mri-scanning-and-the-surgical-findings
#5
Radovan Vojtíšek, Eva Korčáková, Jan Mařan, Ondřej Šorejs, Jindřich Fínek
AIM: To figure out how to correlate the findings on functional MRI and carried out after neoadjuvant CRT of rectal carcinoma with final histology after surgery. BACKGROUND: Neoadjuvant CRT is the standard treatment of locally advanced rectal carcinoma. Its use leads to the downstaging of the disease and in 15-42% of patients even to the detection of pCR after TME. The use of functional MRI improves the sensitivity and specificity of pCR detection up to 52-64% and 89-98%, respectively...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28506596/advances-in-medical-imaging-for-the-diagnosis-and-management-of-common-genitourinary-cancers
#6
REVIEW
Mohammad H Bagheri, Mark A Ahlman, Liza Lindenberg, Baris Turkbey, Jeffrey Lin, Ali Cahid Civelek, Ashkan A Malayeri, Piyush K Agarwal, Peter L Choyke, Les R Folio, Andrea B Apolo
Medical imaging of the 3 most common genitourinary (GU) cancers-prostate adenocarcinoma, renal cell carcinoma, and urothelial carcinoma of the bladder-has evolved significantly during the last decades. The most commonly used imaging modalities for the diagnosis, staging, and follow-up of GU cancers are computed tomography, magnetic resonance imaging (MRI), and positron emission tomography (PET). Multiplanar multidetector computed tomography and multiparametric MRI with diffusion-weighted imaging are the main imaging modalities for renal cell carcinoma and urothelial carcinoma, and although multiparametric MRI is rapidly becoming the main imaging tool in the evaluation of prostate adenocarcinoma, biopsy is still required for diagnosis...
May 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28505176/systematic-multiparametric-analysis-of-mycobacterium-tuberculosis-intracellular-infection-offers-insight-into-coordinated-virulence
#7
Amy K Barczak, Roi Avraham, Shantanu Singh, Samantha S Luo, Wei Ran Zhang, Mark-Anthony Bray, Amelia E Hinman, Matthew Thompson, Raymond M Nietupski, Aaron Golas, Paul Montgomery, Michael Fitzgerald, Roger S Smith, Dylan W White, Anna D Tischler, Anne E Carpenter, Deborah T Hung
A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is the capacity to survive within host macrophages. Although several factors required for this survival have been identified, a comprehensive knowledge of such factors and how they work together to manipulate the host environment to benefit bacterial survival are not well understood. To systematically identify Mtb factors required for intracellular growth, we screened an arrayed, non-redundant Mtb transposon mutant library by high-content imaging to characterize the mutant-macrophage interaction...
May 15, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28503230/utility-of-preoperative-3-tesla-pelvic-phased-array-multiparametric-magnetic-resonance-imaging-in-prediction-of-extracapsular-extension-and-seminal-vesicle-invasion-of-prostate-cancer-and-its-impact-on-surgical-margin-status-experience-at-a-canadian-academic
#8
Taehyoung Lee, Jen Hoogenes, Ian Wright, Edward D Matsumoto, Bobby Shayegan
INTRODUCTION: To evaluate the utility of 3 Tesla (3T) pelvic phased-array (PPA) multiparametric magnetic resonance imaging (mpMRI) to predict extracapsular extension (ECE) and seminal vesicle invasion (SVI) and its subsequent effect on radical prostatectomy (RP) surgical margin status. METHODS: A retrospective evaluation was conducted of RP patients who underwent preoperative 3T PPA mpMRI (without endorectal coil) based on clinical probability of adverse pathological features...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28502474/-role-of-prostate-mri-trus-fusion-biopsies-and-new-markers-in-the-diagnostic-strategy-of-prostate-cancer
#9
Raphaële Renard-Penna, Pierre Mozer, Luca Lunelli, Olivier Cussenot
Multiparametric MRI prostate (mp-MRI) is a powerful tool to locate lesions>0.5cm(3) (below this threshold tumor volume, prostate cancers are classified as "insignificant"). The detection rate of the mp-MRI for significant cancers of small volume (0.5-1cm(3)) with a Gleason score≥7 is>85 %. The prostate mp-MRI optimizes the management of cancers classified as low risk of progression by providing aggressive criteria for misclassified lesions, which require an active treatment and enhance the clinicopathological criteria of indolence for subclinical lesions, which can justify of surveillance...
May 11, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28501565/prostate-zonal-anatomy-correlates-with-the-detection-of-prostate-cancer-on-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-targeted-biopsy-in-patients-with-a-solitary-pi-rads-v2-scored-lesion
#10
Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, Ansh M Bhagat, Steffen Huber, Angelique Levi, Peter Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
PURPOSE: To evaluate the positive predictive value (PPV) of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) assessment method in patients with a single suspicious finding on prostate multiparametric magnetic resonance imaging (mpMRI). PATIENTS AND METHODS: A total of 176 patients underwent MRI/ultrasound fusion-targeted prostate biopsy after the detection of a single suspicious finding on mpMRI. The PPV for cancer detection was determined based on PI-RADS v2 assessment score and location...
May 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28501082/a-high-content-screening-technology-for-quantitatively-studying-podocyte-dynamics
#11
REVIEW
Jochen Reiser, Ha Won Lee, Vineet Gupta, Mehmet M Altintas
Podocytes form the visceral layer of a kidney glomerulus and express a characteristic octopus-like cellular architecture specialized for the ultrafiltration of blood. The cytoskeletal dynamics and structural elasticity of podocytes rely on the self-organization of highly interconnected actin bundles, and the maintenance of these features is important for the intact glomerular filtration. Development of more differentiated podocytes in culture has dramatically increased our understanding of the molecular mechanisms regulating podocyte actin dynamics...
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28497231/t2-mapping-and-t2-imaging-in-heart-failure
#12
REVIEW
A S Lota, P D Gatehouse, R H Mohiaddin
Cardiovascular magnetic resonance (CMR) is a versatile imaging modality that enables aetiological assessment and provides additional information to that of standard echocardiography in a significant proportion of patients with heart failure. In addition to highly accurate and reproducible assessment of ventricular volumes and replacement fibrosis, multiparametric mapping techniques have rapidly evolved to further expand the diagnostic and prognostic applications in various conditions ranging from acute inflammatory and ischaemic cardiomyopathy, to cardiac involvement in systemic diseases such as sarcoidosis and iron overload cardiomyopathy...
May 11, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28496975/convergent-synthesis-and-optical-properties-of-near-infrared-emitting-bioluminescent-infra-luciferins
#13
James C Anderson, Helen Grounds, Amit P Jathoul, James A H Murray, Steven J Pacman, Laurence Tisi
Infra-luciferin, an alkene linked analogue of luciferin, gives bioluminescence emission >700 nm and has the potential to be used for multiparametric in vivo imaging. We report here a high yielding, scalable and convergent synthesis of infra-luciferin which will allow the synthesis of other conjugated luciferins for investigation in near-infrared bioluminescence imaging. We demonstrated this potential by using the new route to synthesise a diene linked analogue of luciferin, the fluorescent and bioluminescent properties of which were compared to those of d-luciferin and infra-luciferin...
January 16, 2017: RSC Advances
https://www.readbyqxmd.com/read/28494579/multiparametric-prostate-mri-technical-conduct-standardized-report-and-clinical-use-a-narrative-review
#14
Matteo Manfredi, Fabrizio Mele, Diletta Garrou, Jochen Walz, Jurgen J Fütterer, Filippo Russo, Lorenzo Vassallo, Arnauld Villers, Mark Emberton, Massimo Valerio
Multiparametric prostate MRI (mp-MRI) is an emerging imaging modality for diagnosis, characterization, staging, and treatment planning of prostate cancer (PCa). The technique, results reporting, and its role in clinical practice have been the subject of significant development over the last decade. Although mp-MRI is not yet routinely used in the diagnostic pathway, almost all urological guidelines have emphasized the potential role of mp-MRI in several aspects of PCa management. Moreover, new MRI sequences and scanning techniques are currently under evaluation to improve the diagnostic accuracy of mp-MRI...
May 11, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28488844/mri-in-prostate-cancer-detection-and-management-a-systematic-review
#15
Fabio Monni, Paolo Fontanella, Angelica Grasso, Peter Wiklund, Yen-Chuan Ou, Marco Randazzo, Bernardo Rocco, Emanuele Montanari, Giampaolo Bianchi
INTRODUCTION: The aim of our work was to evaluate the role of multi-parametric MRI (mpMRI) in detection and management of prostate cancer (PC); specifically investigating the efficacy of mpMRI-based biopsy techniques in terms of diagnostic yield of significant prostate neoplasm and the improved management of patient who choose conservative treatments or active surveillance. EVIDENCE ACQUISITION: A systematic and critical analysis through Medline, Embase, Scopus and Web of Science databases was carried out in March 2016, following the PRISMA ("Preferred Reporting Items for Systematic Reviews and Meta-Analyses") statement...
May 8, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28485391/magnetic-resonance-imaging-targeted-transperineal-prostate-biopsy-a-local-anaesthetic-approach
#16
E J Bass, I A Donaldson, A Freeman, C Jameson, S Punwani, C Moore, M Arya, M Emberton, H U Ahmed
BACKGROUND: Despite high rates of disease misclassification and sepsis, the use of transrectal biopsy remains commonplace. Transperineal mapping biopsies mitigate these problems but carry increased cost and patient burden. Local anaesthetic, multiparametric magnetic resonance imaging (MRI)-targeted transperineal biopsy may offer an alternative. Here, we aim to determine the feasibility, tolerability and detection rates of clinically significant prostate cancer using a local anaesthetic, transperineal, MRI-targeted biopsy technique...
May 9, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28479202/opening-our-eyes-to-multiparametric-magnetic-resonance-imaging-before-prostate-biopsy
#17
EDITORIAL
Hashim U Ahmed
No abstract text is available yet for this article.
May 4, 2017: European Urology
https://www.readbyqxmd.com/read/28479189/mri-based-salvage-brachytherapy-moving-toward-a-focal-paradigm
#18
Marisa A Kollmeier, Michael Zelefsky, Sean McBride
Brachytherapy is an ideal treatment approach for radiorecurrent prostate cancer given the highly conformal treatment. Increasingly, multiparametric magnetic resonance imaging is being utilized to enhance our ability to assess intraprostatic tumor characteristics. This article aims to review the current literature on whole gland salvage brachytherapy for radiorecurrent prostate cancer as well as the methodology and progress towards a focal approach to salvage brachytherapy. Particular emphasis is placed on the potential role of multiparametric MRI in achieving optimal outcomes with focal salvage brachytherapy...
May 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28476529/is-suspicious-upstaging-on-multiparametric-magnetic-resonance-imaging-useful-in-improving-the-reliability-of-prostate-cancer-research-international-active-surveillance-prias-criteria-use-of-the-k-cap-registry
#19
Sagnjun Yoo, Jun Hyuk Hong, Seok-Soo Byun, Ji Youl Lee, Byung Ha Chung, Choung-Soo Kim
BACKGROUND AND OBJECTIVE: To evaluate the clinical effects of suspicious upstaging on multiparametric magnetic resonance imaging (mpMRI) for improving the quality of Prostate Cancer Research International Active Surveillance (PRIAS) criteria. MATERIAL AND METHODS: A total of 363 patients with low-risk prostate cancer (PCa) were selected from the K-CaP registry (the multicenter Korean PCa Database). Patients were divided into 2 groups according to the results of mpMRI (with or without suspicious upstaging)...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28473595/intra-individual-comparison-of-18-f-psma-1007-pet-ct-multi-parametric-mri-and-radical-prostatectomy-specimen-in-patients-with-primary-prostate-cancer-a-retrospective-proof-of-concept-study
#20
Claudia Kesch, Maria Vinsensia, Jan P Radtke, Heinz P Schlemmer, Martina Heller, Elena Ellert, Tim Holland-Letz, Stefan Duensing, Nils Grabe, Ali Afshar-Oromieh, Kathrin Wieczorek, Martin Schäfer, Oliver C Neels, Jens Cardinale, Clemens Kratochwil, Markus Hohenfellner, Klaus Kopka, Uwe Haberkorn, Boris A Hadaschik, Frederik L Giesel
Background:(68)Ga-prostate-specific membrane antigen (PSMA)-11-positron-emission-tomography (PET)/ computer-tomography (CT) represents an advanced method for staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, due to the narrow availability of (68)Ga the development of alternative tracers is of high interest. Objective: To examine the value of the new PET tracer (18)F-PSMA-1007 for staging of local disease by comparing it to multiparametric magnetic resonance imaging (mpMRI) and radical prostatectomy (RP) histopathology...
May 4, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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