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https://www.readbyqxmd.com/read/28429743/novel-sumo-protease-senp7s-regulates-%C3%AE-catenin-signaling-and-mammary-epithelial-cell-transformation
#1
Samaneh Karami, Feng-Ming Lin, Santosh Kumar, Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Yue Li, Jing Ren, Tasneem Bawa-Khalfe
SUMO post-translational modification of proteins or SUMOylation ensures normal cell function. Disruption of SUMO dynamics prompts various pathophysiological conditions, including cancer. The burden of deSUMOylating the large SUMO-proteome rests on 6 full-length mammalian SUMO-proteases or SENP. While multiple SENP isoforms exist, the function of these isoforms remains undefined. We now delineate the biological role of a novel SENP7 isoform SENP7S in mammary epithelial cells. SENP7S is the predominant SENP transcript in human mammary epithelia but is significantly reduced in precancerous ductal carcinoma in situ and all breast cancer subtypes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421778/estimaci%C3%A3-n-del-coste-de-la-nutrici%C3%A3-n-parenteral-domiciliaria-en-espa%C3%A3-a
#2
Rosa Burgos Peláez, María Nuria Virgili Casas, María Cristina Cuerda Compés, José Manuel Moreno Villares, Gabriel Olveira, Luis Miguel Luengo Pérez, Carmina Wanden-Berghe Lozano, Álvaro Muñoz Cuadrado, Covadonga Torres González, Miguel Ángel Casado Gómez
Introducción: la nutrición parenteral domiciliaria (NPD) mejora la calidad de vida de los pacientes permitiéndoles recibir nutrición en su domicilio y facilitando su integración social y laboral.Objetivo: analizar el coste de la NPD en España.Métodos: se realizó una revisión bibliográfica de los Registros de NPD en España (años 2007-2014), elaborados por el Grupo NADYA-SENPE. Se analizó la evolución de: pacientes que requerían NPD, episodios/paciente por los que se administró NPD, duración media de los episodios, vías de acceso y tasa de complicaciones...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28386534/scaffold-of-selenium-nanovectors-and-honey-phytochemicals-for-inhibition-of-pseudomonas-aeruginosa-quorum-sensing-and-biofilm-formation
#3
Prateeksha, Braj R Singh, M Shoeb, S Sharma, A H Naqvi, Vijai K Gupta, Brahma N Singh
Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen Pseudomonas aeruginosa to regulate virulence and biofilm formation. However, lower water solubility and inadequate bioavailability remains major concerns of these therapeutic polyphenols. Its therapeutic index can be improved by using nano-carrier systems to target QS signaling potently. In the present study, we fabricated a unique drug delivery system comprising selenium nanoparticles (SeNPs; non-viral vectors) and polyphenols of honey (HP) for enhancement of anti-QS activity of HP against P...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28383551/p45-nf-e2-regulates-syncytiotrophoblast-differentiation-by-post-translational-gcm1-modifications-in-human-intrauterine-growth-restriction
#4
Shrey Kohli, Juliane Hoffmann, Franziska Lochmann, Paulina Markmeyer, Hanna Huebner, Fabian B Fahlbusch, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Jayakumar Manoharan, Michael Löttge, Ana C Zenclussen, Anat Aharon, Benjamin Brenner, Khurrum Shahzad, Matthias Ruebner, Berend Isermann
Placental insufficiency jeopardizes prenatal development, potentially leading to intrauterine growth restriction (IUGR) and stillbirth. Surviving fetuses are at an increased risk for chronic diseases later in life. IUGR is closely linked with altered trophoblast and placental differentiation. However, due to a paucity of mechanistic insights, suitable biomarkers and specific therapies for IUGR are lacking. The transcription factor p45 NF-E2 (nuclear factor erythroid derived 2) has been recently found to regulate trophoblast differentiation in mice...
April 6, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28356733/a-novel-selective-vpac2-agonist-peptide-conjugated-chitosan-modified-selenium-nanoparticles-with-enhanced-anti-type-2-diabetes-synergy-effects
#5
Shao-Jun Zhao, De-Hua Wang, Yan-Wei Li, Lei Han, Xing Xiao, Min Ma, David Chi-Cheong Wan, An Hong, Yi Ma
A novel neuroendocrine peptide, pituitary adenylate cyclase activating peptide (PACAP), was found to have an important role in carbohydrate or lipid metabolism and was susceptible to dipeptidyl peptidase IV degradation. It can not only mediate glucose-dependent insulin secretion and lower blood glucose by activating VPAC2 receptor, but also raise blood glucose by promoting glucagon production by VPAC1 receptor activation. Therefore, its therapeutic application is restricted by the exceedingly short-acting half-life and the stimulatory function for glycogenolysis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28274870/construction-of-a-cordyceps-sinensis-exopolysaccharide-conjugated-selenium-nanoparticles-and-enhancement-of-their-antioxidant-activities
#6
Yidong Xiao, Qilin Huang, Zhaomin Zheng, Han Guan, Shiyu Liu
A Cordyceps sinensis exopolysaccharide (EPS)-conjugated selenium nanoparticles (SeNPs) were successfully constructed through the reduction of SeO3(2-). The EPS-SeNPs were characterized in terms of formation, morphology, size, Se distribution and phase by UV-vis, FT-IR, transmission electron microscopy (TEM), dynamic light scattering (DLS), energy dispersive X-ray (EDX) and wide angle X-ray diffraction (WAXD) measurements. Results revealed that the SeNPs conjugated to EPS were amorphous and could be well dispersed at a size range of 80-125nm...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28270147/selenium-nanoparticles-decorated-with-ulva-lactuca-polysaccharide-potentially-attenuate-colitis-by-inhibiting-nf-%C3%AE%C2%BAb-mediated-hyper-inflammation
#7
Chenghui Zhu, Shuimei Zhang, Chengwei Song, Yibo Zhang, Qinjie Ling, Peter R Hoffmann, Jun Li, Tianfeng Chen, Wenjie Zheng, Zhi Huang
BACKGROUND: Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the digestive tract. Se nanoparticles (SeNPs) exhibit anti-inflammatory activity accompanied by low toxicity, especially when decorated with natural biological compounds. Herein, we explored the beneficial effects of SeNPs decorated with Ulva lactuca polysaccharide (ULP) in mice subjected to the acute colitis model...
March 7, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28261763/effects-of-selenium-nanoparticles-on-reproductive-performance-of-male-sprague-dawley-rats-at-supranutritional-and-nonlethal-levels
#8
Lujie Liu, Yudan He, Zhiping Xiao, Wenjing Tao, Jia Zhu, Bin Wang, Zixun Liu, Minqi Wang
This research investigated the influence of selenium nanoparticles (SeNPs) on the reproductive performance of male Sprague-Dawley (SD) rats. A suspension of SeNPs was consecutively administered by oral gavage for 2 weeks at supranutritional (0.2, 0.4, or 0.8 mg Se/kg bw) and nonlethal (2.0, 4.0, or 8.0 mg Se/kg bw) levels to male SD rats. The normal control (NC) rats were exposed to physiological saline alone. Biochemical parameters, sperm motility, gene expression of GPx1 and GPx4, and histopathological evaluation of male spermary were measured in this work...
March 6, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28254334/selenium-nanoparticles-synthesized-in-aqueous-extract-of-allium-sativum-perturbs-the-structural-integrity-of-calf-thymus-dna-through-intercalation-and-groove-binding
#9
Preedia Babu Ezhuthupurakkal, Lokeswara Rao Polaki, Arumugam Suyavaran, Ariraman Subastri, Venugopal Sujatha, Chinnasamy Thirunavukkarasu
Biomedical application of selenium nanoparticles (SeNPs) demands the eco-friendly composite for synthesis of SeNPs. The present study reports an aqueous extract of Allium sativum (AqEAS) plug-up the current need. Modern spectroscopic, microscopic and gravimetric techniques were employed to characterize the synthesized nanoparticles. Characterization studies revealed the formation of crystalline spherical shaped SeNPs. FTIR spectrum brings out the presence of different functional groups in AqEAS, which influence the SeNPs formation and stabilization...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28244767/registro-del-grupo-nadya-senpe-de-nutrici%C3%A3-n-enteral-domiciliaria-en-espa%C3%A3-a-a%C3%A3-os-2014-y-2015
#10
Carmina Wanden-Berghe, Luis Miguel Luengo, Julia Álvarez, Rosa Burgos, Cristina Cuerda, Pilar Matía, Carmen Gómez Candela, Miguel Ángel Martínez Olmos, Montserrat Gonzalo, Alicia Calleja, Cristina Campos, Antonio Pérez de la Cruz, José Antonio Irles, Pere Leyes, Rebeca Sánchez, Daniel De Luis Román, Daniel Cardona, Nieves Santacruz, José Pablo Suárez, Carmen Ballesta, Jordi Salas, María Ángeles Penacho, Carmen Gardez, María José Martínez, Bárbara Cánovas, José Manuel Moreno, Dolores Del Olmo, Fátima Carabaña, Nuria Virgili, Isabel Higuera, Silvia Mauri, Olga Sánchez-Vilar, Nuria Miserachs, Miguel Ángel Ponce, Yaiza García, Jesús M Morán, Antxón Apezetxea, Cristina Tejera, Alfonso Calañas, Ana Cantón, Patricia Díaz, Grupo Nadya-Senpe
Objetivo: exponer los resultados del registro de nutrición enteral domiciliaria (NED) del año 2014 y 2015 del Grupo NADYA-SENPE.Métodos: se recopilaron los pacientes introducidos en el registro desde el 1 de enero al 31 de diciembre de 2014 y la mismas fechas de 2015, y se procedió al análisis descriptivo y analítico de los datos.Resultados: en el año 2014, se registraron 3.749 pacientes y en 2015, 4.202; la prevalencia fue de 80,58 pacientes/millón de habitantes en el año 2014 y de 90,51 en 2015. Por sexos, hubo un 49,9% de mujeres en 2014 y un 50,3% en 2015...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28243649/a-go-se-nanocomposite-as-an-antioxidant-nanozyme-for-cytoprotection
#11
Yanyan Huang, Chaoqun Liu, Fang Pu, Zhen Liu, Jinsong Ren, Xiaogang Qu
GO-Se nanocomposites are fabricated with excellent glutathione peroxidase (GPx)-like properties to protect cells against oxidative stress. Compared with SeNPs, the GO-Se nanozymes exhibit higher GPx-mimic catalytic efficiency. Cell experiments further confirm their excellent cytoprotection capacity.
February 28, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28120612/h2o2-depleting-and-o2-generating-selenium-nanoparticles-for-fluorescence-imaging-and-photodynamic-treatment-of-proinflammatory-activated-macrophages
#12
Kun-Ying Lu, Po-Yen Lin, Er-Yuan Chuang, Chwen-Ming Shih, Tsai-Mu Cheng, Tsung-Yao Lin, Hsing-Wen Sung, Fwu-Long Mi
Macrophages have a pivotal role in chronic inflammatory diseases (CIDs), so imaging and controlling activated macrophage is critical for detecting and reducing chronic inflammation. In this study, photodynamic selenium nanoparticles (SeNPs) with photosensitive and macrophage-targeting bilayers were developed. The first layer of the photosensitive macromolecule was composed of a conjugate of a photosensitizer (rose bengal, RB) and a thiolated chitosan (chitosan-glutathione), resulting in a plasmonic coupling-induced red shift and broadening of RB absorption bands with increased absorption intensity...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056992/antioxidant-capacities-of-the-selenium-nanoparticles-stabilized-by-chitosan
#13
Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren, Xiaojing Leng
BACKGROUNDS: Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with zero oxidation state (Se(0)) has captured our attention because of its low toxicity and excellent bioavailability. However, Se(0) is very unstable and easily changes into the inactive form. By now many efforts have been done to protect its stability. And this work was conducted to explore the antioxidant capacities of the stable Se(0) nanoparticles (SeNPs) stabilized using chitosan (CS) with different molecular weights (Mws) (CS-SeNPs)...
January 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28000484/nutrici%C3%A3-n-parenteral-domiciliaria-en-espa%C3%A3-a-durante-2015-informe-del-grupo-de-nutrici%C3%A3-n-artificial-domiciliaria-y-ambulatoria-nadya
#14
Carmina Wanden-Berghe Lozano, Cristina Campos Martín, Cristina Cuerda Compes, Carmen Gómez Candela, Rosa Burgos Peláez, José Manuel Moreno Villares, José Luis Pereira Cunill, Antonio Pérez de la Cruz, Nuria Virgili Casas, Ceferino Martinez Faedo, Julia Álvarez Hernández, Carmen Garde Orbaiz, Mª Ángeles Penacho Lázaro, Eva Ángeles Sánchez Martos, Alejandro Sanz Paris, Montserrat Gonzalo Marín, Ana Zugasti Murillo, Pilar Matía Martín, Tomás Martín Folgueras, Fátima Carabaña Pérez, Patricia Díaz Guardiola, Cristina Tejera Pérez, Daniel De Luis Román, Luis Miguel Luengo Pérez, Nieves Santacruz Carmona, Antxón Apezetxea Celaya, Miguel Ángel Ponce González, Juan Ramón Urgeles Planella, Lucía Laborda González, Miguel Ángel Martinez Olmos, Olga Sánchez-Vilar Burdiel, Clara Joaquín Ortiz, Cecilia Martínez Costa, José Pablo Suárez Llanos, Alicia Calleja Fernández, Pere Leyes García, Mª Carmen Gil Martinez, Silvia Mauri Roca, Maria Victoria García Zafra, María José Carrera Santaliestra, Grupo Nadya-Senpe
Objetivo: Comunicar los datos del registro de Nutrición Parenteral Domiciliaria (NPD) del grupo de trabajo NADYA-SENPE del años 2015.Material y métodos: Recopilación de los datos de NPD del registro "on-line" del grupo de Nutrición Artificial Domiciliaria y Ambulatoria (NADYA) desde el 1 de enero de 2015 al 31 de diciembre de 2015.Resultados: Se registraron 236 pacientes, con 243 episodios de NPD procedentes de 40 hospitales. Lo que representa una tasa de 5,08 pacientes/millón de habitantes/ año 2015...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27895727/deficiency-of-sumo-specific-protease-1-induces-arsenic-trioxide-mediated-apoptosis-by-regulating-xbp1-activity-in-human-acute-promyelocytic-leukemia
#15
Fei-Fei Wang, Ming-Zhu Liu, Yi Sui, Qing Cao, Bo Yan, Mei-Ling Jin, Xi Mo
Small ubiquitin-like modifier (SUMO)/sentrin-specific protease 1 (SENP1), a member of the SENP family, is highly expressed in several neoplastic tissues. However, the effect of SENP1 in acute promyelocytic leukemia (APL) has not been elucidated. In the present study, it was observed that SENP1 deficiency had no effect on the spontaneous apoptosis or differentiation of NB4 cells. Arsenic trioxide (As2O3) could induce the upregulation of endoplasmic reticulum (ER) stress, resulting in the apoptosis of NB4 cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27869771/selenium-nanoparticles-attenuate-oxidative-stress-and-testicular-damage-in-streptozotocin-induced-diabetic-rats
#16
Mohamed A Dkhil, Rafat Zrieq, Saleh Al-Quraishy, Ahmed E Abdel Moneim
We investigated the protective and antioxidative effects of selenium nanoparticles (SeNPs) in streptozotocin STZ-induced diabetic rats. STZ-diabetic rats were exposed daily to treatments with SeNPs and/or insulin and then the effect of these treatments on the parameters correlated to oxidative damage of the rat testes were assessed. Biochemical analysis revealed that SeNPs are able to ameliorate the reduction in the serum testosterone caused by STZ-induced diabetes. Furthermore, SeNPs could significantly decrease testicular tissue oxidative stress markers, namely lipid peroxidation and nitric oxide...
November 19, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27866615/anti-neoplastic-selenium-nanoparticles-from-idiomarina-sp-pr58-8
#17
Pallavee Srivastava, Meenal Kowshik
Selenium nanoparticles (SeNPs) with novel biological activities, cancer cell selectivity, and low toxicity towards normal cells have gained attention for chemo-therapeutic and chemo-preventive applications. These nanoparticles may be synthesized using micro-organisms, which is the green alternative of nanofabrication. Here we report the intracellular synthesis of SeNPs by the moderate halophilic bacterium, Idiomarina sp. PR58-8 using sodium selenite as the precursor. Characterization of SeNPs by XRD exhibited the characteristic Bragg's peak of hexagonal selenium with a crystallite domain size of 34nm...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27832715/green-synthesis-of-selenium-nanoparticles-conjugated-clausena-dentata-plant-leaf-extract-and-their-insecticidal-potential-against-mosquito-vectors
#18
P Sowndarya, G Ramkumar, M S Shivakumar
Mosquitoes are major vectors for the transmission of many diseases like chikungunya, malaria, dengue, zika, etc. worldwide. In the present study, selenium nanoparticles (SeNPs) were synthesized from Clausena dentata and were tested for their larvicidal efficacy against the fourth-instar larvae of Anopheles stephensi, Aedes Aegypti, and Culex quinquefasciatus. The synthesized nanoparticles were characterized using UV-Vis spectroscopy, Fourier Transform Infrared Radiation (FTIR) spectroscopy, EDaX, and SEM. The results recorded from UV-Vis spectroscopy show the peak absorption spectrum at 420 nm...
November 10, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27741516/senp1-promotes-proliferation-of-clear-cell-renal-cell-carcinoma-through-activation-of-glycolysis
#19
Baijun Dong, Yujing Gao, Xunlei Kang, Hongchang Gao, Jin Zhang, Hua Guo, Mingjian J You, Wei Xue, Jinke Cheng, Yiran Huang
Metabolic shift toward aerobic glycolysis is a fundamental element contributing to the development and progression of clear cell renal cell carcinoma (ccRCC). We and others previously observed enhanced glycolysis and diminished tricarboxylic acid (TCA) cycle activity in ccRCC tissue. Here, by integrated gene expression and metabolomic analyses of 36 matched pairs of tumor and adjacent normal tissues, we showed that expression of Sentrin/SUMO-specific protease 1 (SENP1) is positively associated with glycolysis levels in ccRCC...
December 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27717878/insights-into-selenite-reduction-and-biogenesis-of-elemental-selenium-nanoparticles-by-two-environmental-isolates-of-burkholderia-fungorum
#20
Nazanin Seyed Khoei, Silvia Lampis, Emanuele Zonaro, Kim Yrjälä, Paolo Bernardi, Giovanni Vallini
Microorganisms capable of transforming toxic selenium oxyanions into non-toxic elemental selenium (Se°) may be considered as biocatalysts for the production of selenium nanoparticles (SeNPs), eventually exploitable in different biotechnological applications. Two Burkholderia fungorum strains (B. fungorum DBT1 and B. fungorum 95) were monitored during their growth for both capacity and efficiency of selenite (SeO3(2-)) reduction and elemental selenium formation. Both strains are environmental isolates in origin: B...
January 25, 2017: New Biotechnology
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