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https://www.readbyqxmd.com/read/28120612/h2o2-depleting-and-o2-generating-selenium-nanoparticles-for-fluorescence-imaging-and-photodynamic-treatment-of-proinflammatory-activated-macrophages
#1
Kun-Ying Lu, Po-Yen Lin, Er-Yuan Chuang, Chwen-Ming Shih, Tsai-Mu Cheng, Tsung-Yao Lin, Hsing-Wen Sung, Fwu-Long Mi
Macrophages have a pivotal role in chronic inflammatory diseases (CIDs), so imaging and controlling activated macrophage is critical for detecting and reducing chronic inflammation. In this study, photodynamic selenium nanoparticles (SeNPs) with photosensitive and macrophage-targeting bilayers were developed. The first layer of the photosensitive macromolecule was composed of a conjugate of a photosensitizer (rose bengal, RB) and a thiolated chitosan (chitosan-glutathione), resulting in a plasmonic coupling-induced red shift and broadening of RB absorption bands with increased absorption intensity...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056992/antioxidant-capacities-of-the-selenium-nanoparticles-stabilized-by-chitosan
#2
Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren, Xiaojing Leng
BACKGROUNDS: Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with zero oxidation state (Se(0)) has captured our attention because of its low toxicity and excellent bioavailability. However, Se(0) is very unstable and easily changes into the inactive form. By now many efforts have been done to protect its stability. And this work was conducted to explore the antioxidant capacities of the stable Se(0) nanoparticles (SeNPs) stabilized using chitosan (CS) with different molecular weights (Mws) (CS-SeNPs)...
January 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28000484/nutrici%C3%A3-n-parenteral-domiciliaria-en-espa%C3%A3-a-durante-2015-informe-del-grupo-de-nutrici%C3%A3-n-artificial-domiciliaria-y-ambulatoria-nadya
#3
Carmina Wanden-Berghe Lozano, Cristina Campos Martín, Cristina Cuerda Compes, Carmen Gómez Candela, Rosa Burgos Peláez, José Manuel Moreno Villares, José Luis Pereira Cunill, Antonio Pérez de la Cruz, Nuria Virgili Casas, Ceferino Martinez Faedo, Julia Álvarez Hernández, Carmen Garde Orbaiz, Mª Ángeles Penacho Lázaro, Eva Ángeles Sánchez Martos, Alejandro Sanz Paris, Montserrat Gonzalo Marín, Ana Zugasti Murillo, Pilar Matía Martín, Tomás Martín Folgueras, Fátima Carabaña Pérez, Patricia Díaz Guardiola, Cristina Tejera Pérez, Daniel De Luis Román, Luis Miguel Luengo Pérez, Nieves Santacruz Carmona, Antxón Apezetxea Celaya, Miguel Ángel Ponce González, Juan Ramón Urgeles Planella, Lucía Laborda González, Miguel Ángel Martinez Olmos, Olga Sánchez-Vilar Burdiel, Clara Joaquín Ortiz, Cecilia Martínez Costa, José Pablo Suárez Llanos, Alicia Calleja Fernández, Pere Leyes García, Mª Carmen Gil Martinez, Silvia Mauri Roca, Maria Victoria García Zafra, María José Carrera Santaliestra, Grupo Nadya-Senpe
Objetivo: Comunicar los datos del registro de Nutrición Parenteral Domiciliaria (NPD) del grupo de trabajo NADYA-SENPE del años 2015.Material y métodos: Recopilación de los datos de NPD del registro "on-line" del grupo de Nutrición Artificial Domiciliaria y Ambulatoria (NADYA) desde el 1 de enero de 2015 al 31 de diciembre de 2015.Resultados: Se registraron 236 pacientes, con 243 episodios de NPD procedentes de 40 hospitales. Lo que representa una tasa de 5,08 pacientes/millón de habitantes/ año 2015...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27895727/deficiency-of-sumo-specific-protease-1-induces-arsenic-trioxide-mediated-apoptosis-by-regulating-xbp1-activity-in-human-acute-promyelocytic-leukemia
#4
Fei-Fei Wang, Ming-Zhu Liu, Yi Sui, Qing Cao, Bo Yan, Mei-Ling Jin, Xi Mo
Small ubiquitin-like modifier (SUMO)/sentrin-specific protease 1 (SENP1), a member of the SENP family, is highly expressed in several neoplastic tissues. However, the effect of SENP1 in acute promyelocytic leukemia (APL) has not been elucidated. In the present study, it was observed that SENP1 deficiency had no effect on the spontaneous apoptosis or differentiation of NB4 cells. Arsenic trioxide (As2O3) could induce the upregulation of endoplasmic reticulum (ER) stress, resulting in the apoptosis of NB4 cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27869771/selenium-nanoparticles-attenuate-oxidative-stress-and-testicular-damage-in-streptozotocin-induced-diabetic-rats
#5
Mohamed A Dkhil, Rafat Zrieq, Saleh Al-Quraishy, Ahmed E Abdel Moneim
We investigated the protective and antioxidative effects of selenium nanoparticles (SeNPs) in streptozotocin STZ-induced diabetic rats. STZ-diabetic rats were exposed daily to treatments with SeNPs and/or insulin and then the effect of these treatments on the parameters correlated to oxidative damage of the rat testes were assessed. Biochemical analysis revealed that SeNPs are able to ameliorate the reduction in the serum testosterone caused by STZ-induced diabetes. Furthermore, SeNPs could significantly decrease testicular tissue oxidative stress markers, namely lipid peroxidation and nitric oxide...
November 19, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27866615/anti-neoplastic-selenium-nanoparticles-from-idiomarina-sp-pr58-8
#6
Pallavee Srivastava, Meenal Kowshik
Selenium nanoparticles (SeNPs) with novel biological activities, cancer cell selectivity, and low toxicity towards normal cells have gained attention for chemo-therapeutic and chemo-preventive applications. These nanoparticles may be synthesized using micro-organisms, which is the green alternative of nanofabrication. Here we report the intracellular synthesis of SeNPs by the moderate halophilic bacterium, Idiomarina sp. PR58-8 using sodium selenite as the precursor. Characterization of SeNPs by XRD exhibited the characteristic Bragg's peak of hexagonal selenium with a crystallite domain size of 34nm...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27832715/green-synthesis-of-selenium-nanoparticles-conjugated-clausena-dentata-plant-leaf-extract-and-their-insecticidal-potential-against-mosquito-vectors
#7
P Sowndarya, G Ramkumar, M S Shivakumar
Mosquitoes are major vectors for the transmission of many diseases like chikungunya, malaria, dengue, zika, etc. worldwide. In the present study, selenium nanoparticles (SeNPs) were synthesized from Clausena dentata and were tested for their larvicidal efficacy against the fourth-instar larvae of Anopheles stephensi, Aedes Aegypti, and Culex quinquefasciatus. The synthesized nanoparticles were characterized using UV-Vis spectroscopy, Fourier Transform Infrared Radiation (FTIR) spectroscopy, EDaX, and SEM. The results recorded from UV-Vis spectroscopy show the peak absorption spectrum at 420 nm...
November 10, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27741516/senp1-promotes-proliferation-of-clear-cell-renal-cell-carcinoma-through-activation-of-glycolysis
#8
Baijun Dong, Yujing Gao, Xunlei Kang, Hongchang Gao, Jin Zhang, Hua Guo, Mingjian J You, Wei Xue, Jinke Cheng, Yiran Huang
Metabolic shift toward aerobic glycolysis is a fundamental element contributing to the development and progression of clear cell renal cell carcinoma (ccRCC). We and others previously observed enhanced glycolysis and diminished tricarboxylic acid (TCA) cycle activity in ccRCC tissue. Here, by integrated gene expression and metabolomic analyses of 36 matched pairs of tumor and adjacent normal tissues, we showed that expression of Sentrin/SUMO-specific protease 1 (SENP1) is positively associated with glycolysis levels in ccRCC...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27717878/insights-into-selenite-reduction-and-biogenesis-of-elemental-selenium-nanoparticles-by-two-environmental-isolates-of-burkholderia-fungorum
#9
Nazanin Seyed Khoei, Silvia Lampis, Emanuele Zonaro, Kim Yrjälä, Paolo Bernardi, Giovanni Vallini
Microorganisms capable of transforming toxic selenium oxyanions into non-toxic elemental selenium (Se°) may be considered as biocatalysts for the production of selenium nanoparticles (SeNPs), eventually exploitable in different biotechnological applications. Two Burkholderia fungorum strains (B. fungorum DBT1 and B. fungorum 95) were monitored during their growth for both capacity and efficiency of selenite (SeO3(2-)) reduction and elemental selenium formation. Both strains are environmental isolates in origin: B...
January 25, 2017: New Biotechnology
https://www.readbyqxmd.com/read/27649656/the-sumo-specific-protease-senp5-controls-dna-damage-response-and-promotes-tumorigenesis-in-hepatocellular-carcinoma
#10
Z-L Jin, H Pei, Y-H Xu, J Yu, T Deng
OBJECTIVE: SUMOylation plays critical roles in a variety of physiological and pathological processes including tumorigenesis. SUMOylation is a reversible process which is mediated by the SENP (Sentrin/SUMO-specific protease) family to remove SUMO from conjugated substrates. SENP5 has been reported to play critical roles in the control of several cancers including breast cancer, osteosarcoma and oral squamous cell carcinoma. In this study, we uncovered a role of SENP5 in promoting tumorigenesis process in hepatocellular carcinoma (HCC) via regulating DNA damage response...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27644314/senp2-expression-was-induced-by-chronic-glucose-stimulation-in-ins1-cells-and-it-was-required-for-the-associated-induction-of-ccnd1-and-mafa
#11
Hye Seung Jung, Yu Mi Kang, Ho Seon Park, Byung Yong Ahn, Hakmo Lee, Min Joo Kim, Jin Young Jang, Sun-Whe Kim
Post-translational modification by bonding of small ubiquitin-like modifier (SUMO) peptides influences various cellular functions, and is regulated by SUMO-specific proteases (SENPs). Several proteins have been suggested to have diverse impact on insulin synthesis and secretion through SUMO modification in β cells. However, the role of SUMO modification in β cell mass has not been established. Here, we examined the changes in expression of Senp in INS1 cells and pancreatic islets under diabetes-relevant stress conditions and associated changes in β cell mass...
November 2016: Islets
https://www.readbyqxmd.com/read/27631802/in-vitro-characterization-of-chain-depolymerization-activities-of-sumo-specific-proteases
#12
Julia Eckhoff, R Jürgen Dohmen
SUMO-specific proteases, known as Ulps in baker's yeast and SENPs in humans, have important roles in controlling the dynamics of SUMO-modified proteins. They display distinct modes of action and specificity, in that they may act on the SUMO precursor, mono-sumoylated, and/or polysumoylated proteins, and they might be specific for substrates with certain SUMO paralogs. SUMO chains may be dismantled either by endo or exo mechanisms. Biochemical characterization of a protease usually requires purification of the protein of interest...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27630128/reduction-of-selenite-to-se-0-nanoparticles-by-filamentous-bacterium-streptomyces-sp-es2-5-isolated-from-a-selenium-mining-soil
#13
Yuanqing Tan, Rong Yao, Rui Wang, Dan Wang, Gejiao Wang, Shixue Zheng
BACKGROUND: Selenium (Se) is an essential trace element in living systems. Microorganisms play a pivotal role in the selenium cycle both in life and in environment. Different bacterial strains are able to reduce Se(IV) (selenite) and (or) Se(VI) (selenate) to less toxic Se(0) with the formation of Se nanoparticles (SeNPs). The biogenic SeNPs have exhibited promising application prospects in medicine, biosensors and environmental remediation. These microorganisms might be explored as potential biofactories for synthesis of metal(loid) nanoparticles...
September 15, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27626674/sumo-signaling-by-hypoxic-inactivation-of-sumo-specific-isopeptidases
#14
Kathrin Kunz, Kristina Wagner, Luca Mendler, Soraya Hölper, Nathalie Dehne, Stefan Müller
Post-translational modification of proteins with ubiquitin-like SUMO modifiers is a tightly regulated and highly dynamic process. The SENP family of SUMO-specific isopeptidases comprises six cysteine proteases. They are instrumental in counterbalancing SUMO conjugation, but their regulation is not well understood. We demonstrate that in hypoxic cell extracts, the catalytic activity of SENP family members, in particular SENP1 and SENP3, is inhibited in a rapid and fully reversible process. Comparative mass spectrometry from normoxic and hypoxic cells defines a subset of hypoxia-induced SUMO1 targets, including SUMO ligases RanBP2 and PIAS2, glucose transporter 1, and transcriptional regulators...
September 13, 2016: Cell Reports
https://www.readbyqxmd.com/read/27576863/allosteric-activation-of-senp1-by-sumo1-%C3%AE-grasp-domain-involves-a-dock-and-coalesce-mechanism
#15
Jingjing Guo, Huan-Xiang Zhou
Small ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMOylation of target proteins. The β-grasp domain of SUMOs binds to an exosite cleft, and allosterically activates SENPs via an unknown mechanism. Our molecular dynamics simulations showed that binding of the β-grasp domain induces significant conformational and dynamic changes in SENP1, including widening of the exosite cleft and quenching of nanosecond dynamics in all but a distal region...
August 31, 2016: ELife
https://www.readbyqxmd.com/read/27561515/shape-controlled-synthesis-of-cubic-like-selenium-nanoparticles-via-the-self-assembly-method
#16
Urarika Luesakul, Seamkwan Komenek, Songchan Puthong, Nongnuj Muangsin
The ability to control the morphology of nanoparticles by molecular design and synthesis is gaining increasing attention for achieving improved unique properties. In this work, we designed the chemical structure of a stabilizer for controlling the shape of selenium nanoparticles (SeNPs) via a self-assembly process. When folic acid-gallic acid-N,N,N-trimethyl chitosan (FA-GA-TMC) was used as a stabilizer, SeNPs were observed to self-organize into cubic-like structures with an average size of approximately 300nm...
November 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27533297/selenium-nanoparticles-incorporated-into-titania-nanotubes-inhibit-bacterial-growth-and-macrophage-proliferation
#17
Wenwen Liu, Negar H Golshan, Xuliang Deng, Daniel J Hickey, Katherine Zeimer, Hongyi Li, Thomas J Webster
Since implants often fail due to infection and uncontrolled inflammatory responses, we designed an in vitro study to investigate the antibacterial and anti-inflammatory properties of titanium dioxide nanotubes (TNTs) incorporated with selenium nanoparticles (SeNPs). Selenium incorporation was achieved by the reaction of sodium selenite (Na2SeO3) with glutathione (GSH) under a vacuum in the presence of TNTs. Two types of bacteria and macrophages were cultured on the samples to determine their respective antibacterial and anti-inflammatory properties...
August 25, 2016: Nanoscale
https://www.readbyqxmd.com/read/27497969/nano-selenium-as-antioxidant-agent-in-a-multilayer-food-packaging-material
#18
Paula Vera, Yolanda Echegoyen, Elena Canellas, Cristina Nerín, María Palomo, Yolanda Madrid, Carmen Cámara
Selenium nanoparticles (SeNPs) were incorporated in a flexible multilayer plastic material using a water-base adhesive as vehicle for SeNPs. The antioxidant performance of the original solutions containing spherical SeNPs of 50-60 nm diameter, the adhesive containing these SeNPs, and the final multilayer plastic material to be used as food packaging were quantitatively measured. The radical scavenging capacity due to SeNPs was quantified by a free radical assay developed in the laboratory and by the diphenyl-1-picrylhydrazyl (DPPH) method...
September 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27402164/hsdna-groove-binding-photocatalytic-activity-and-in-vitro-breast-and-colon-cancer-cell-reducing-function-of-greener-senps
#19
Amol V Pansare, Dnyaneshwar K Kulal, Amol A Shedge, Vishwanath R Patil
Selenium nanoparticles (SeNPs) have attracted great attention because of their superior optical properties and wide utilization in biological and biomedical studies. This paper reports an environmentally benign procedure of greener monodispersible SeNP synthesis using the reducing power of Trigonella foenum-graecum extract, characterization and their protective effect against unfolded (Herring sperm DNA) hsDNA. We investigated the anti-cancer activity of SeNPs against MCF-7, MDA MB 435 and COLO-205 cells. The photocatalytic activity of SeNPs was investigated for the degradation of a Sunset Yellow FCF (SYFCF) dye using ultraviolet-B light...
July 26, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27356860/selenium-nanoparticles-as-a-nutritional-supplement
#20
REVIEW
Sylvie Skalickova, Vedran Milosavljevic, Kristyna Cihalova, Pavel Horky, Lukas Richtera, Vojtech Adam
Selenium is an essential trace element in the diet, required for maintenance of health and growth; however, its toxicity could cause serious damage depending on dose and chemical form. Selenium nanoparticles (SeNPs) represent what we believe to be a novel prospect for nutritional supplementation because of their lower toxicity and ability to gradually release selenium after ingestion. In this review, we discuss various forms and types of SeNPs, as well as the way they are synthesized. We also discuss absorption and bioavailability of nanoparticles within the organism...
January 2017: Nutrition
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