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https://www.readbyqxmd.com/read/27895727/deficiency-of-sumo-specific-protease-1-induces-arsenic-trioxide-mediated-apoptosis-by-regulating-xbp1-activity-in-human-acute-promyelocytic-leukemia
#1
Fei-Fei Wang, Ming-Zhu Liu, Yi Sui, Qing Cao, Bo Yan, Mei-Ling Jin, Xi Mo
Small ubiquitin-like modifier (SUMO)/sentrin-specific protease 1 (SENP1), a member of the SENP family, is highly expressed in several neoplastic tissues. However, the effect of SENP1 in acute promyelocytic leukemia (APL) has not been elucidated. In the present study, it was observed that SENP1 deficiency had no effect on the spontaneous apoptosis or differentiation of NB4 cells. Arsenic trioxide (As2O3) could induce the upregulation of endoplasmic reticulum (ER) stress, resulting in the apoptosis of NB4 cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27869771/selenium-nanoparticles-attenuate-oxidative-stress-and-testicular-damage-in-streptozotocin-induced-diabetic-rats
#2
Mohamed A Dkhil, Rafat Zrieq, Saleh Al-Quraishy, Ahmed E Abdel Moneim
We investigated the protective and antioxidative effects of selenium nanoparticles (SeNPs) in streptozotocin STZ-induced diabetic rats. STZ-diabetic rats were exposed daily to treatments with SeNPs and/or insulin and then the effect of these treatments on the parameters correlated to oxidative damage of the rat testes were assessed. Biochemical analysis revealed that SeNPs are able to ameliorate the reduction in the serum testosterone caused by STZ-induced diabetes. Furthermore, SeNPs could significantly decrease testicular tissue oxidative stress markers, namely lipid peroxidation and nitric oxide...
November 19, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27866615/anti-neoplastic-selenium-nanoparticles-from-idiomarina-sp-pr58-8
#3
Pallavee Srivastava, Meenal Kowshik
Selenium nanoparticles (SeNPs) with novel biological activities, cancer cell selectivity, and low toxicity towards normal cells have gained attention for chemo-therapeutic and chemo-preventive applications. These nanoparticles may be synthesized using micro-organisms, which is the green alternative of nanofabrication. Here we report the intracellular synthesis of SeNPs by the moderate halophilic bacterium, Idiomarina sp. PR58-8 using sodium selenite as the precursor. Characterization of SeNPs by XRD exhibited the characteristic Bragg's peak of hexagonal selenium with a crystallite domain size of 34nm...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27832715/green-synthesis-of-selenium-nanoparticles-conjugated-clausena-dentata-plant-leaf-extract-and-their-insecticidal-potential-against-mosquito-vectors
#4
P Sowndarya, G Ramkumar, M S Shivakumar
Mosquitoes are major vectors for the transmission of many diseases like chikungunya, malaria, dengue, zika, etc. worldwide. In the present study, selenium nanoparticles (SeNPs) were synthesized from Clausena dentata and were tested for their larvicidal efficacy against the fourth-instar larvae of Anopheles stephensi, Aedes Aegypti, and Culex quinquefasciatus. The synthesized nanoparticles were characterized using UV-Vis spectroscopy, Fourier Transform Infrared Radiation (FTIR) spectroscopy, EDaX, and SEM. The results recorded from UV-Vis spectroscopy show the peak absorption spectrum at 420 nm...
November 10, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27741516/senp1-promotes-proliferation-of-clear-cell-renal-cell-carcinoma-through-activation-of-glycolysis
#5
Baijun Dong, Yujing Gao, Xunlei Kang, Hongchang Gao, Jin Zhang, Hua Guo, Mingjian J You, Wei Xue, Jinke Cheng, Yiran Huang
Metabolic shift toward aerobic glycolysis is a fundamental element contributing to the development and progression of clear cell renal cell carcinoma (ccRCC). We and others previously observed enhanced glycolysis and diminished tricarboxylic acid (TCA) cycle activity in ccRCC tissue. Here, by integrated gene expression and metabolomic analyses of 36 matched pairs of tumor and adjacent normal tissues, we showed that expression of Sentrin/SUMO-specific protease 1 (SENP1) is positively associated with glycolysis levels in ccRCC...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27717878/insights-into-selenite-reduction-and-biogenesis-of-elemental-selenium-nanoparticles-by-two-environmental-isolates-of-burkholderia-fungorum
#6
Nazanin Seyed Khoei, Silvia Lampis, Emanuele Zonaro, Kim Yrjälä, Paolo Bernardi, Giovanni Vallini
Microorganisms capable of transforming toxic selenium oxyanions into non-toxic elemental selenium (Se°) may be considered as biocatalysts for the production of selenium nanoparticles (SeNPs), eventually exploitable in different biotechnological applications. Two Burkholderia fungorum strains (B. fungorum DBT1 and B. fungorum 95) were monitored during their growth for both capacity and efficiency of selenite (SeO3(2-)) reduction and elemental selenium formation. Both strains are environmental isolates in origin: B...
January 25, 2017: New Biotechnology
https://www.readbyqxmd.com/read/27649656/the-sumo-specific-protease-senp5-controls-dna-damage-response-and-promotes-tumorigenesis-in-hepatocellular-carcinoma
#7
Z-L Jin, H Pei, Y-H Xu, J Yu, T Deng
OBJECTIVE: SUMOylation plays critical roles in a variety of physiological and pathological processes including tumorigenesis. SUMOylation is a reversible process which is mediated by the SENP (Sentrin/SUMO-specific protease) family to remove SUMO from conjugated substrates. SENP5 has been reported to play critical roles in the control of several cancers including breast cancer, osteosarcoma and oral squamous cell carcinoma. In this study, we uncovered a role of SENP5 in promoting tumorigenesis process in hepatocellular carcinoma (HCC) via regulating DNA damage response...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27644314/senp2-expression-was-induced-by-chronic-glucose-stimulation-in-ins1-cells-and-it-was-required-for-the-associated-induction-of-ccnd1-and-mafa
#8
Hye Seung Jung, Yu Mi Kang, Ho Seon Park, Byung Yong Ahn, Hakmo Lee, Min Joo Kim, Jin Young Jang, Sun-Whe Kim
Post-translational modification by bonding of small ubiquitin-like modifier (SUMO) peptides influences various cellular functions, and is regulated by SUMO-specific proteases (SENPs). Several proteins have been suggested to have diverse impact on insulin synthesis and secretion through SUMO modification in beta cells. However, the role of SUMO modification in beta cell mass has not been established. Here, we examined the changes in expression of Senp in INS1 cells and pancreatic islets under diabetes-relevant stress conditions and associated changes in beta cell mass...
September 20, 2016: Islets
https://www.readbyqxmd.com/read/27631802/in-vitro-characterization-of-chain-depolymerization-activities-of-sumo-specific-proteases
#9
Julia Eckhoff, R Jürgen Dohmen
SUMO-specific proteases, known as Ulps in baker's yeast and SENPs in humans, have important roles in controlling the dynamics of SUMO-modified proteins. They display distinct modes of action and specificity, in that they may act on the SUMO precursor, mono-sumoylated, and/or polysumoylated proteins, and they might be specific for substrates with certain SUMO paralogs. SUMO chains may be dismantled either by endo or exo mechanisms. Biochemical characterization of a protease usually requires purification of the protein of interest...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27630128/reduction-of-selenite-to-se-0-nanoparticles-by-filamentous-bacterium-streptomyces-sp-es2-5-isolated-from-a-selenium-mining-soil
#10
Yuanqing Tan, Rong Yao, Rui Wang, Dan Wang, Gejiao Wang, Shixue Zheng
BACKGROUND: Selenium (Se) is an essential trace element in living systems. Microorganisms play a pivotal role in the selenium cycle both in life and in environment. Different bacterial strains are able to reduce Se(IV) (selenite) and (or) Se(VI) (selenate) to less toxic Se(0) with the formation of Se nanoparticles (SeNPs). The biogenic SeNPs have exhibited promising application prospects in medicine, biosensors and environmental remediation. These microorganisms might be explored as potential biofactories for synthesis of metal(loid) nanoparticles...
2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27626674/sumo-signaling-by-hypoxic-inactivation-of-sumo-specific-isopeptidases
#11
Kathrin Kunz, Kristina Wagner, Luca Mendler, Soraya Hölper, Nathalie Dehne, Stefan Müller
Post-translational modification of proteins with ubiquitin-like SUMO modifiers is a tightly regulated and highly dynamic process. The SENP family of SUMO-specific isopeptidases comprises six cysteine proteases. They are instrumental in counterbalancing SUMO conjugation, but their regulation is not well understood. We demonstrate that in hypoxic cell extracts, the catalytic activity of SENP family members, in particular SENP1 and SENP3, is inhibited in a rapid and fully reversible process. Comparative mass spectrometry from normoxic and hypoxic cells defines a subset of hypoxia-induced SUMO1 targets, including SUMO ligases RanBP2 and PIAS2, glucose transporter 1, and transcriptional regulators...
September 13, 2016: Cell Reports
https://www.readbyqxmd.com/read/27576863/allosteric-activation-of-senp1-by-sumo1-%C3%AE-grasp-domain-involves-a-dock-and-coalesce-mechanism
#12
Jingjing Guo, Huan-Xiang Zhou
Small ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMOylation of target proteins. The β-grasp domain of SUMOs binds to an exosite cleft, and allosterically activates SENPs via an unknown mechanism. Our molecular dynamics simulations showed that binding of the β-grasp domain induces significant conformational and dynamic changes in SENP1, including widening of the exosite cleft and quenching of nanosecond dynamics in all but a distal region...
2016: ELife
https://www.readbyqxmd.com/read/27561515/shape-controlled-synthesis-of-cubic-like-selenium-nanoparticles-via-the-self-assembly-method
#13
Urarika Luesakul, Seamkwan Komenek, Songchan Puthong, Nongnuj Muangsin
The ability to control the morphology of nanoparticles by molecular design and synthesis is gaining increasing attention for achieving improved unique properties. In this work, we designed the chemical structure of a stabilizer for controlling the shape of selenium nanoparticles (SeNPs) via a self-assembly process. When folic acid-gallic acid-N,N,N-trimethyl chitosan (FA-GA-TMC) was used as a stabilizer, SeNPs were observed to self-organize into cubic-like structures with an average size of approximately 300nm...
November 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27533297/selenium-nanoparticles-incorporated-into-titania-nanotubes-inhibit-bacterial-growth-and-macrophage-proliferation
#14
Wenwen Liu, Negar H Golshan, Xuliang Deng, Daniel J Hickey, Katherine Zeimer, Hongyi Li, Thomas J Webster
Since implants often fail due to infection and uncontrolled inflammatory responses, we designed an in vitro study to investigate the antibacterial and anti-inflammatory properties of titanium dioxide nanotubes (TNTs) incorporated with selenium nanoparticles (SeNPs). Selenium incorporation was achieved by the reaction of sodium selenite (Na2SeO3) with glutathione (GSH) under a vacuum in the presence of TNTs. Two types of bacteria and macrophages were cultured on the samples to determine their respective antibacterial and anti-inflammatory properties...
August 25, 2016: Nanoscale
https://www.readbyqxmd.com/read/27497969/nano-selenium-as-antioxidant-agent-in-a-multilayer-food-packaging-material
#15
Paula Vera, Yolanda Echegoyen, Elena Canellas, Cristina Nerín, María Palomo, Yolanda Madrid, Carmen Cámara
Selenium nanoparticles (SeNPs) were incorporated in a flexible multilayer plastic material using a water-base adhesive as vehicle for SeNPs. The antioxidant performance of the original solutions containing spherical SeNPs of 50-60 nm diameter, the adhesive containing these SeNPs, and the final multilayer plastic material to be used as food packaging were quantitatively measured. The radical scavenging capacity due to SeNPs was quantified by a free radical assay developed in the laboratory and by the diphenyl-1-picrylhydrazyl (DPPH) method...
September 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27402164/hsdna-groove-binding-photocatalytic-activity-and-in-vitro-breast-and-colon-cancer-cell-reducing-function-of-greener-senps
#16
Amol V Pansare, Dnyaneshwar K Kulal, Amol A Shedge, Vishwanath R Patil
Selenium nanoparticles (SeNPs) have attracted great attention because of their superior optical properties and wide utilization in biological and biomedical studies. This paper reports an environmentally benign procedure of greener monodispersible SeNP synthesis using the reducing power of Trigonella foenum-graecum extract, characterization and their protective effect against unfolded (Herring sperm DNA) hsDNA. We investigated the anti-cancer activity of SeNPs against MCF-7, MDA MB 435 and COLO-205 cells. The photocatalytic activity of SeNPs was investigated for the degradation of a Sunset Yellow FCF (SYFCF) dye using ultraviolet-B light...
July 26, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27356860/selenium-nanoparticles-as-a-nutritional-supplement
#17
REVIEW
Sylvie Skalickova, Vedran Milosavljevic, Kristyna Cihalova, Pavel Horky, Lukas Richtera, Vojtech Adam
Selenium is an essential trace element in the diet, required for maintenance of health and growth; however, its toxicity could cause serious damage depending on dose and chemical form. Selenium nanoparticles (SeNPs) represent what we believe to be a novel prospect for nutritional supplementation because of their lower toxicity and ability to gradually release selenium after ingestion. In this review, we discuss various forms and types of SeNPs, as well as the way they are synthesized. We also discuss absorption and bioavailability of nanoparticles within the organism...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27347128/downregulation-of-senp1-inhibits-cell-proliferation-migration-and-promotes-apoptosis-in-human-glioma-cells
#18
Qiu-Sheng Zhang, Meng Zhang, Xian-Jian Huang, Xiao-Jia Liu, Wei-Ping Li
Small ubiquitin-related modifier protein (SUMO) is an evolutionarily conserved protein in a broad range of eukaryotic organisms. De-SUMOylation, the reverse reaction of SUMOylation, is regulated by a family of SUMO-specific proteases (SENPs). SENP1 is a member of the de-SUMOylation protease family involved in the de-SUMOylation of a variety of SUMOylated proteins. The present study demonstrates that small hairpin RNA (shRNA)-mediated downregulation of SENP1 inhibits cell proliferation and migration, and promotes apoptosis in human glioma cells...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27344494/identification-of-senp1-inhibitors-through-in-silico-screening-and-rational-drug-design
#19
Yaxue Zhao, Zhongli Wang, Jianchen Zhang, Huchen Zhou
The small ubiquitin-related modifier (SUMO)-specific proteases (SENPs) catalyze the deconjugation of SUMO from their substrate proteins. SENP1 which is the most studied isoform is closely related to many cancers such as prostate cancer and colon cancer, thus representing a potential therapeutic target for cancer treatment. In the present study, we identified eleven SENP1 inhibitors representing a variety of scaffolds through in silico screening. Based on these scaffolds, a series of new compounds were designed and synthesized in order to improve their SENP1 inhibitory potency...
October 21, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27319803/biogenic-selenium-nanoparticles-characterization-antimicrobial-activity-and-effects-on-human-dendritic-cells-and-fibroblasts
#20
Eleonora Cremonini, Emanuele Zonaro, Marta Donini, Silvia Lampis, Marzia Boaretti, Stefano Dusi, Paola Melotti, Maria M Lleo, Giovanni Vallini
Tailored nanoparticles offer a novel approach to fight antibiotic-resistant microorganisms. We analysed biogenic selenium nanoparticles (SeNPs) of bacterial origin to determine their antimicrobial activity against selected pathogens in their planktonic and biofilm states. SeNPs synthesized by Gram-negative Stenotrophomonas maltophilia [Sm-SeNPs(-)] and Gram-positive Bacillus mycoides [Bm-SeNPs(+)] were active at low minimum inhibitory concentrations against a number of clinical isolates of Pseudomonas aeruginosa but did not inhibit clinical isolates of the yeast species Candida albicans and C...
June 20, 2016: Microbial Biotechnology
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