keyword
MENU ▼
Read by QxMD icon Read
search

SENP

keyword
https://www.readbyqxmd.com/read/29146736/quantitative-high-throughput-screening-identifies-cytoprotective-molecules-that-enhance-sumo-conjugation-via-the-inhibition-of-sumo-specific-protease-senp-2
#1
Joshua D Bernstock, Daniel Ye, Jayden A Smith, Yang-Ja Lee, Florian A Gessler, Adam Yasgar, Jennifer Kouznetsova, Ajit Jadhav, Zhuoran Wang, Stefano Pluchino, Wei Zheng, Anton Simeonov, John M Hallenbeck, Wei Yang
The development of novel neuroprotective treatments for acute stroke has been fraught with failures, which supports the view of ischemic brain damage as a highly complex multifactorial process. Post-translational modifications such as small ubiquitin-like modifier (SUMO)ylation have emerged as critical molecular regulatory mechanisms in states of both homeostasis and ischemic stress, as evidenced by our previous work. Accordingly, the clinical significance of the selective control of the global SUMOylation process has become apparent in studies of ischemic pathobiology and pathophysiology...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29142221/biogenic-selenium-and-its-hepatoprotective-activity
#2
Baozhen Li, Dan Li, Weixin Jing, Jinhua Fan, Hans-Uwe Dahms, Shao-Chin Lee, Lan Wang
Elemental selenium nanoparticles (SeNPs) have multiple biological activities. In this study, we investigated the protective effects of biogenic SeNPs (BioSeNPs) on CCl4-induced liver damage in mice. The results showed that: (i) when compared to sodium selenite (SS), BioSeNPs has a similar tissue distribution after intragastrical administration to mice; (ii) BioSeNPs and SS showed comparable efficacy in increasing the activities of glutathione peroxidase and thioredoxin reductase in liver cell lines, mice blood and liver; (iii) pretreatment with BioSeNPs inhibiting the elevation of activities of various enzymes significantly which included aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and liver lipid peroxide (p < 0...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141577/extracellular-synthesis-of-selenium-nanoparticles-from-an-actinomycetes-streptomyces-griseoruber-and-evaluation-of-its-cytotoxicity-on-ht-29-cell-line
#3
V R Ranjitha, Ravishankar Rai Vittal
In the present study, the extracellular synthesis of Selenium nanoparticles (SeNPs) was carried out by using culture supernatant of Streptomyces griseoruber, an Actinomycetes member isolated from the soil. Bioreduction of SeNPs was confirmed by UV-Visible spectrophotometer that showed the peak at 575 nm. XRD pattern confirmed the non-crystalline or amorphous nature of the synthesised SeNPs. FTIR spectra revealed the possible functional group that is responsible for mediating the SeNPs formation. Size and distribution of the biosynthesised SeNPs were analysed by HR-TEM that showed the formation of particle size in the range of 100-250nm...
November 13, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29124492/biogenesis-of-selenium-nanoparticles-using-green-chemistry
#4
REVIEW
Sara Shoeibi, Paul Mozdziak, Afsaneh Golkar-Narenji
Selenium binds some enzymes such as glutathione peroxidase and thioredoxin reductase, which may be activated in biological infections and oxidative stress. Chemical and physical methods for synthesizing nanoparticles, apart from being expensive, have their own particular risks. However, nanoparticle synthesis through green chemistry is a safe procedure that different biological sources such as bacteria, fungi, yeasts, algae and plants can be the catalyst bed for processing. Synthesis of selenium nanoparticles (SeNPs) by macro/microorganisms causes variation in morphology and shape of the particles is due to diversity of reduction enzymes in organisms...
November 9, 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/29111042/fabrication-and-stabilization-of-biocompatible-selenium-nanoparticles-by-carboxylic-curdlans-with-various-molecular-properties
#5
Jing-Kun Yan, Wen-Yi Qiu, Yao-Yao Wang, Wen-Han Wang, Yan Yang, He-Nan Zhang
In this study, carboxylic curdlans (Cur-4, Cur-8, and Cur-24) with different molecular properties and chain conformations were used as stabilizer and capping agent to fabricate stable and water-dispersible selenium nanoparticles (SeNPs). Results showed that molecular properties and chain conformations of carboxylic curdlans remarkably influenced the size, morphology, structure, and stability of SeNPs and the carboxylic curdlan was ligated to SeNPs via OH⋯Se interaction. The as-prepared SeNPs was amorphous and showed homogeneous and monodisperse spherical structure with size of ∼50-90nm...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29095026/organization-and-management-of-clinical-nutrition-in-spain-how-do-we-assess-the-quality-of-our-activities
#6
Tomás Martín Folgueras, María Dolores Ballesteros Pomar, Rosa Burgos Peláez, María Victoria Calvo Hernández, Luis Miguel Luengo Pérez, José Antonio Irles Rocamora, Gabriel Olveira, Alfonso Vidal Casariego, Julia Alvarez Hernández
INTRODUCTION: Among the objectives of the SENPE Management Working Group is the development of knowledge and tools related to the evaluation of health outcomes. OBJECTIVES: To obtain an approximate profile of clinical nutrition in hospitals in Spain, specifically concerning its organization, endowment, activities and quality indicators. METHODS: A cross-sectional study conducted in 2013 through a structured survey sent to a random sample of 20% of hospitals from the network of the National Health System of Spain, stratified by the number of hospital beds...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29095014/-prevalence-of-nutritional-risk-and-malnutrition-established-in-outpatient-institutionalized-and-hospitalized-populations-in-a-health-department
#7
Icíar Castro-Vega, Silvia Veses Martin, Juana Cantero Llorca, Cristina Barrios Marta, Núria Monzó Albiach, Celia Bañuls Morant, Antonio Hernández-Mijares
INTRODUCTION: The prevalence of disease-related malnutrition depends on the population studied and the methods used for screening, for nutritional assessment and the diagnostic criteria employed. OBJECTIVES: To determine the prevalence of nutritional risk and malnutrition, and the type and degree of malnutrition in outpatient, hospitalized and institutionalized populations in a health department. MATERIAL AND METHODS: Cross-sectional and descriptive study with a randomly selected sample...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29090279/selenium-nanoparticles-induce-suppressed-function-of-tumor-associated-macrophages-and-inhibit-dalton-s-lymphoma-proliferation
#8
Pramod Kumar Gautam, Sanjay Kumar, M S Tomar, Rishi Kant Singh, A Acharya, Sanjay Kumar, B Ram
Selenium Nanoparticle (SeNPs) is reported that it enhances and maintains optimal immune during infection and malignancies. To this end, we examined the role of selenium on TAMS whose anti-tumor function suppressed which favor tumor progression. BALB/c (H2d) strain of mice non-Hodgkin type of Dalton's cell line was used to check the role of carboxlic group induced, synthesized SeNPs on TAMs. Screening of IC50 value was done primarily trypen blue exclusion assay and 50% proliferation of DL cells inhibited 40 ng/ml to 50 ng/...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29054148/determination-of-size-and-mass-and-number-based-concentration-of-biogenic-senps-synthesized-by-lactic-acid-bacteria-by-using-a-multimethod-approach
#9
Gustavo Moreno-Martin, Micaela Pescuma, Teresa Pérez-Corona, Fernanda Mozzi, Yolanda Madrid
Selenium nanoparticles (SeNPs) were synthesized by a green technology using lactic acid bacteria (LAB, Lactobacillus acidophilus, L. delbrueckii subsp. bulgaricus and L. reuteri). The exposure of aqueous sodium selenite to LAB led to the synthesis of SeNPs. Characterization of SeNPs by transmission electron microscopy with energy dispersive X-ray spectrum (EDXS) analysis revealed the presence of stable, predominantly monodispersed and spherical SeNPs of an average size of 146 ± 71 nm. Additionally, SeNPs hydrodynamic size was determined by dispersive light scattering (DLS) and nanoparticle tracking analysis (NTA)...
November 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29043926/efficient-induction-of-apoptosis-in-cancer-cells-by-paclitaxel-loaded-selenium-nanoparticles
#10
Anil Parsram Bidkar, Pallab Sanpui, Siddhartha Sankar Ghosh
AIM: To develop selenium nanoparticles (SeNPs)-based delivery systems for paclitaxel (PTX) and assess their antiproliferative efficacy against cancer cells in vitro with potential mechanistic insight. METHODS: Pluronic F-127 stabilized SeNPs were prepared and characterized. Effects of PTX-loaded SeNPs on lung (A549), breast (MCF7), cervical (HeLa) and colon (HT29) cancer cells were studied by viability assay complemented with flow-cytometric analyses of cell cycle, apoptosis, mitochondrial membrane potential, intracellular reactive oxygen species and caspase activity...
October 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29032211/discrete-senps-macromolecule-binding-manipulated-by-hydrophilic-interaction
#11
Amol V Pansare, Amol A Shedge, Vishwanath R Patil
Nanoparticle-protein conjugates are promising probes for biological diagnostics and versatile building blocks for nanotechnology. Here we demonstrate the interaction of SeNPs with BSA macromolecule simply by physical adsorption method. The interaction between SeNPs and BSA has been investigated by UV-Vis, fluorescence, circular dichroism (CD) spectroscopic and thermal methods. The esterase-like activity of BSA towards PNPA was investigated in the presence of SeNPs. The effects of SeNPs on the stability and conformational changes of BSA were studied, which indicated that the binding of SeNPs with BSA induced relative changes in secondary structure of protein...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29017880/development-physicochemical-characterization-and-cytotoxicity-of-selenium-nanoparticles-stabilized-by-beta-lactoglobulin
#12
Jinglin Zhang, Zi Teng, Yang Yuan, Qing-Zhu Zeng, Zhiyuan Lou, Seong-Ho Lee, Qin Wang
Novel Selenium nanoparticles (SeNPs) were developed using beta-lactoglobulin (Blg) as a stabilizer in redox systems of selenite and ascorbic acid in this study. Particle size, morphology, stability, and in vitro biological activity of synthesized Blg stabilized selenium nanoparticles (Blg-SeNPs) were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), ultraviolet-visible spectrophotometry (UV/Vis), and cell toxicity assays, respectively. Stabilizing mechanisms of Blg-SeNPs were investigated by Fourier-transform infrared spectroscopy (FTIR) and protein fluorescence probe...
October 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28979122/green-synthesis-of-selenium-nanoparticles-using-acinetobacter-sp-sw30-optimization-characterization-and-its-anticancer-activity-in-breast-cancer-cells
#13
Sweety A Wadhwani, Mahadeo Gorain, Pinaki Banerjee, Utkarsha U Shedbalkar, Richa Singh, Gopal C Kundu, Balu A Chopade
The aim of this study was to synthesize selenium nanoparticles (SeNPs) using cell suspension and total cell protein of Acinetobacter sp. SW30 and optimize its synthesis by studying the influence of physiological and physicochemical parameters. Also, we aimed to compare its anticancer activity with that of chemically synthesized SeNPs in breast cancer cells. Cell suspension of Acinetobacter sp. SW30 was exposed to various physiological and physicochemical conditions in the presence of sodium selenite to study their effects on the synthesis and morphology of SeNPs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28974580/sumoylation-regulates-nuclear-accumulation-and-signaling-activity-of-the-soluble-intracellular-domain-of-the-erbb4-receptor-tyrosine-kinase
#14
Anna Maria Knittle, Maria Helkkula, Mark S Johnson, Maria Sundvall, Klaus Elenius
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase-activated signaling cascades. Previously, we have demonstrated that ErbB4 ICD is posttranslationally modified by the small ubiquitin-like modifier (SUMO) and functionally interacts with the PIAS3 SUMO E3 ligase. However, direct evidence of SUMO modification in ErbB4 signaling has remained elusive. Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2 and 5...
October 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28947299/validity-efficacy-and-reliability-of-3-nutritional-screening-tools-regarding-the-nutritional-assessment-in-different-social-and-health-areas
#15
Iciar Castro-Vega, Silvia Veses Martín, Juana Cantero Llorca, Cristina Barrios Marta, Celia Bañuls, Antonio Hernández-Mijares
INTRODUCTION AND OBJECTIVE: Nutritional screening allows for the detection of nutritional risk. Validated tools should be implemented, and their usefulness should be contrasted with a gold standard. The aim of this study is to discover the validity, efficacy and reliability of 3 nutritional screening tools in relation to complete nutritional assessment. MATERIAL AND METHODOLOGY: A sub-analysis of a cross-sectional and descriptive study on the prevalence of disease-related malnutrition...
September 22, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28938209/interactions-between-biogenic-selenium-nanoparticles-and-goethite-colloids-and-consequence-for-remediation-of-elemental-mercury-contaminated-groundwater
#16
Xiaonan Wang, Daoyong Zhang, Haifeng Qian, Yan Liang, Xiangliang Pan, Geoffrey Michael Gadd
Ubiquitous colloidal minerals such as goethite can have a significant impact on the performance of nanoparticles-based groundwater remediation due to aggregation. Heteroaggregation and retention of Se nanoparticles (SeNPs) by goethite in groundwater, and its impact on Hg(0) remediation by SeNPs were investigated in this study. In order to mitigate the adverse effects of aggregation, the effects of bacterial extracellular polymeric substances (EPS) on the stability of SeNPs and Hg(0) sequestration using SeNPs were also evaluated...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28892302/cancer-targeted-selenium-nanoparticles-sensitize-cancer-cells-to-continuous-%C3%AE-radiation-to-achieve-synergetic-chemo-radiotherapy
#17
Leung Chan, Lizhen He, Binwei Zhou, Shouhai Guan, Mingjun Bo, Yahui Yang, Ying Liu, Xiao Liu, Yanyang Zhang, Qiang Xie, Tianfeng Chen
Cancer radiotherapy with 125I seeds demonstrates long-term higher efficacy and lower side effects than traditional X-ray radiotherapy due to its low-dose and continuous radiation but is still limited by radioresistance in clinical applications. Therefore, the design and synthesis for sensitizers that could enhance the sensitivity of cancer cells to 125I seeds is of great importance for future radiotherapy. Selenium nanoparticles (SeNPs) have been found to exhibit high potential in cancer chemotherapy and as drug carriers...
September 11, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28884683/characterisation-of-the-biflavonoid-hinokiflavone-as-a-pre-mrna-splicing-modulator-that-inhibits-senp
#18
Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formation of the B complex. Cells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors required for A complex formation, which relocalize together with SUMO1 and SUMO2 into enlarged nuclear speckles containing polyadenylated RNA...
September 8, 2017: ELife
https://www.readbyqxmd.com/read/28880681/synthesis-and-antioxidant-properties-of-lycium-barbarum-polysaccharides-capped-selenium-nanoparticles-using-tea-extract
#19
Wenjing Zhang, Juan Zhang, Dejun Ding, Liping Zhang, Luis Alexandre Muehlmann, Shu-E Deng, Xuedong Wang, Wentong Li, Weifen Zhang
Selenium nanoparticles (SeNPs) have attracted increasing interest over the last decades because of their activities on redox balance in human body. However, the SeNPs tend to aggregate into large clusters, resulting in lower bioactivity, bioavailability and biocompatibility. Surface-capping agents on SeNPs play crucial roles in its stabilization and biological activity. Here, a green synthesis method for the preparation of Lycium barbarum polysaccharides capped SeNPs using green tea extracts as reductants under mild conditions, at room temperature, is reported...
September 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28859809/selenium-nanoparticle-enriched-biomass-of-yarrowia-lipolytica-enhances-growth-and-survival-of-artemia-salina
#20
Faseela Hamza, Amogh Vaidya, Mugdha Apte, Ameeta Ravi Kumar, Smita Zinjarde
Controlling disease outbreaks is a major challenge in aquaculture farms and conventional methods are often ineffective. Nutritional supplementation and probiotic preparations help in reducing severity of such infections. The generally regarded as safe yeast (Yarrowia lipolytica) was used in the current study. A marine strain of Y. lipolytica exhibited tolerance towards sodium selenite and formed cell associated selenium nanoparticles (SeNPs). The synthesized nanoparticles were characterized by UV-vis spectroscopy, X-ray diffraction (XRD) and Field Emission Scanning Electron Microscope (FE-SEM) observations...
November 2017: Enzyme and Microbial Technology
keyword
keyword
60805
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"