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Icíar Castro-Vega, Silvia Veses Martín, Juana Cantero Llorca, Christian Salom Vendrell, Celia Bañuls, Antonio Hernández Mijares
INTRODUCTION: nutritional screenings are used to detect nutritional risk, allow early intervention and influence the prognosis. The Malnutrition Screening Tool (MST) is only validated in hospitalized patients and oncology outpatients. OBJECTIVES: to analyze the nutritional screening MST, Malnutrition Universal Screening Tool (MUST) and Mini Nutritional Assessment-Short Form (MNA-sf) compared to the nutritional assessment gold standard according to socio-sanitary areas and age groups; and to assess the utility of the MST in those areas where it has not been validated...
February 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Hua-Rong Luo, Ying Liu, Xiao-Dong Wan, Jun-Liang Li, Min Wu, Qi-Min Zhang, Deng-Long Wu, Xin Zhao, Tian-Ru Wang
BACKGROUND/AIMS: SUMOylation is a dynamic process and reversed by the activity of SUMO-specific proteases (SENPs) family. SENP1, a member of this family, is highly expressed and plays oncogenic roles in diverse cancers including prostate cancer. However, the SENP1-transgenic mice exhibit aberrant transformation of the mouse prostate gland but do not develop cancer. Cellular Stress Response 1 (CSR1) is a tumor suppressor gene and frequently deleted in prostate cancers. Overexpression of CSR1 in prostate cancer cells inhibits colony formation, anchorage-independent growth and induces cell death...
April 25, 2018: Cellular Physiology and Biochemistry
Ahmad Reza Shahverdi, Faranak Shahverdi, Elnaz Faghfuri, Mohammad Reza Khoshayand, Faranak Mavandadnejad, Mohammad Hossein Yazdi, Mohsen Amini
BACKGROUNDS AND AIMS: Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in vitro and in vivo effects of SeNPs and folic acid surface-coated selenium nanoparticles (FA@SeNPs) on breast cancer. METHODS: FA@SeNPs and SeNPs were chemically synthesized and characterized with different instrumental techniques. The cytotoxicity of both nanomaterials was evaluated against 4T1 cells...
April 23, 2018: Archives of Medical Research
Abdulsalam A Alkhudhayri, Mohamed A Dkhil, Saleh Al-Quraishy
Background: Although elemental selenium has been found to be effective against Eimeria , no study has yet investigated the effects of selenium nanoparticles (SeNPs) on the Eimeria parasite. The aim of this study, therefore, was to evaluate the ameliorative effect of SeNPs compared with elemental selenium on mice jejunum infected with sporulated oocysts of Eimeria papillata . Methods: The mice were divided into 4 groups, with the first being the non-infected, control group, and the second, third, and fourth groups being orally inoculated with 1,000 sporulated oocysts of E...
2018: International Journal of Nanomedicine
Xian Xia, Zijie Zhou, Shijuan Wu, Dan Wang, Shixue Zheng, Gejiao Wang
Selenite reductase CsrF overexpressed Escherichia coli was used as a microbial factory to produce Se(0) nanoparticles (Bio-SeNPs). The Bio-SeNPs were characterized by transmission electronic microscopy, element mapping, scanning electron microscopy, energy-dispersive X-ray spectrographs, Zeta-potential, dynamic light scattering, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses. The results indicated that Bio-SeNPs are irregular spheres with diameters from 60 to105 nm and mainly consist of Se(0), proteins and lipids...
April 12, 2018: Nanomaterials
Yuntao Liu, Siqi Zeng, Yixi Liu, Wenjuan Wu, Yingbin Shen, Lan Zhang, Cheng Li, Hong Chen, Aiping Liu, Li Shen, Bin Hu, Caixia Wang
Selenium nanoparticles (SeNPs) were prepared by adding Catathelasma ventricosum polysaccharides (CVPs) to the redox system of selenite and ascorbic acid. Taking particle size as an investigation index, the optimal synthesis conditions of CVPs-SeNPs were obtained by orthogonal test. Herein, the diameter, morphology, and stability of the CVPs-SeNPs were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the antidiabetic activities of CVPs-SeNPs were evaluated by STZ (streptozocin)-induced diabetic mice...
March 27, 2018: International Journal of Biological Macromolecules
Yu Xia, Min Guo, Tiantian Xu, Yinghua Li, Changbing Wang, Zhengfang Lin, Mingqi Zhao, Bing Zhu
Background: Small interfering RNA (siRNA) as a new therapeutic modality holds promise for cancer treatment. However, the traditional viral carriers are prone to immunogenicity and risk of insertional mutagenesis. Methods: In order to provide a tumor-targeted delivery carrier of siRNA in cancer therapy, the hyaluronic acid (HA)-selenium (Se)-polyethylenimine (PEI) nanoparticle (NP) was fabricated by decorating SeNP with HA as a tumor-targeting moiety and by linking the polycationic polymers polyethylenimine PEI onto the surface of SeNP...
2018: International Journal of Nanomedicine
Wanwen Chen, Lin Yue, Qixing Jiang, Xiaoli Liu, Wenshui Xia
We reported an innovative approach to the synthesis of varisized chitosan-selenium (CS-Se) nanocomposites, which for the first time used CS both as a reductant and stabilizer to synthesize CS-Se nanocomposites. By manipulating the temperature, the well-dispersed CS-Se nanocomposites were synthesized via a simple one pot reaction with the size ranging from 83 to 208 nm before being characterized by TEM, DLS, UV-vis, FTIR, XRD and TG analyses. The results showed that SeO3 2- was reduced to a stable SeNPs colloid at a comparatively high temperature and the amino group and part of hydroxyl group of CS were conjugated to the surface of SeNPs...
March 24, 2018: International Journal of Biological Macromolecules
Carmen Gómez Candela, Samara Palma Milla, Alberto Miján-de-la-Torre, Pilar Rodríguez Ortega, Viviana Loria Kohen, Rocío Campos Del Portillo, M ª Nuria Virgili Casas, Miguel Á Martínez Olmos, M ª Teresa Mories Álvarez, M ª José Castro Alija, Ángela Martín-Palmero
Eating disorders (ED) are characterized by persistent changes in eating habits that negatively affect a person's health and psychosocial abilities. They are considered psychiatric disorders, highly variable in their presentation and severity, with a huge impact on nutrition, which conditions various therapeutic approaches within a key multidisciplinary context. A group of experts in nutrition, we decided to set up a task force adscribed to the "Sociedad Española de Nutrición Parenteral y Enteral" (SENPE), which has stated as one of its goals the development of a consensus document to generate a protocol based on the best scientific evidence and professional experience available in order to improve health care in this field...
March 7, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Kathrin Kunz, Tanja Piller, Stefan Müller
The ubiquitin-related SUMO system controls many cellular signaling networks. In mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent modifiers of up to thousands of cellular proteins. SUMO conjugation affects cell function mainly by regulating the plasticity of protein networks. Importantly, the modification is reversible and highly dynamic. Cysteine proteases of the sentrin-specific protease (SENP) family reverse SUMO conjugation in mammalian cells. In this Cell Science at a Glance article and the accompanying poster, we will summarize how the six members of the mammalian SENP family orchestrate multifaceted deconjugation events to coordinate cell processes, such as gene expression, the DNA damage response and inflammation...
March 20, 2018: Journal of Cell Science
Ding Xu, Lichen Yang, Yu Wang, Gejiao Wang, Christopher Rensing, Shixue Zheng
Elemental selenium nanoparticles (SeNPs) are useful in medicine, environmental remediation and in material science. Biosynthesized SeNPs (BioSeNPs) by bacteria are cheap, eco-friendly and have a lower cytotoxicity in comparison with chemically synthesized ones. Organic matters were found to cap on the surface of BioSeNPs, but the functions were still not entirely clear. The purified BioSeNPs were coated in a thick layer of organic substrates observed by transmission electron microscopy (TEM). Fourier Transform Infrared (FT-IR) and quantitative detection of the coating agents showed that one gram of purified BioSeNPs bound 1069 mg proteins, 23 mg carbohydrates and only very limited amounts of lipids...
March 19, 2018: Scientific Reports
Julián Esteban Sáez, Cristian Arredondo, Carlos Rivera, María Estela Andrés
CoREST family of transcriptional co-repressors regulates gene expression and cell fate determination during development. CoREST co-repressors recruit with different affinity the histone demethylase LSD1 (KDM1A) and the deacetylases HDAC1/2 to repress with variable strength the expression of target genes. CoREST protein levels are differentially regulated during cell fate determination and in mature tissues. However, regulatory mechanisms of CoREST co-repressors at the protein level have not been studied. Here, we report that CoREST (CoREST1, RCOR1) and its homologs CoREST2 (RCOR2) and CoREST3 (RCOR3) interact with PIASγ (protein inhibitor of activated STAT), a SUMO (small ubiquitin-like modifier)-E3-ligase...
April 23, 2018: Biochemical Journal
Mengjuan Shi, Cunli Zhang, Ivan Fan Xia, Siu To Cheung, Kwong Sen Wong, Ka-Hing Wong, Doris W T Au, David E Hinton, Kevin W H Kwok
Selenium (Se) is an essential element and its biological activity is related to its speciation. It is also well-known that in excess it can cause teratogenesis in fish and birds. In this study we compared dietary toxicity of elemental selenium nanoparticles (SeNPs) with selenite and selenomethionine (Se-Met). Japanese medaka (Oryzias latipes) was used as a laboratory model to determine Se effects on adults and their offspring. Adult females were individually exposed using a dry diet fortified with 0, 10 or 20 µg/g of the three Se species for 7 days and then allowed to breed for 3 days...
July 30, 2018: Ecotoxicology and Environmental Safety
Hayeon Baik, Mathias Boulanger, Mohsen Hosseini, Julie Kowalczyk, Sonia Zaghdoudi, Tamara Salem, Jean-Emmanuel Sarry, Yosr Hicheri, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis
Differentiation therapies using all- trans retinoic acid (ATRA) are highly efficient at treating acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). However, their efficacy, if any, is limited in the case of non-APL AML. We report here that inhibition of SUMOylation, a posttranslational modification related to ubiquitination, restores the prodifferentiation and antiproliferative activities of retinoids in non-APL AML. Controlled inhibition of SUMOylation with the pharmacologic inhibitors 2-D08 or anacardic acid, or via overexpression of SENP deSUMOylases, enhanced the ATRA-induced expression of key genes involved in differentiation, proliferation, and apoptosis in non-APL AML cells...
February 27, 2018: Cancer Research
Huihui Ji, He Zhang, Chenlong Li, Tian Senping, Junwei Lu, Yunliang Wei
The H∞ control problem for a class of time-delay systems with randomly occurring nonlinearities (RONs) is addressed in this paper. Sensor saturations, missing measurements and channel fadings are governed by random variables obeying the Bernoulli distributions. The measurement output is subject to both data missing and randomly occurring sensor saturations (ROSSs) described by sector-nonlinearities as well as the channel fadings caused typically in wireless communication. The aim of the addressed problem is to design a full-order dynamic output-feedback controller such that the closed-loop system is exponentially mean-square stable and satisfies the prescribed H∞ performance constraint...
April 2018: ISA Transactions
Bo Wei, Chao Huang, Bin Liu, Yang Wang, Nansong Xia, Qiuju Fan, Guo-Qiang Chen, Jinke Cheng
Progression of mitotic cell cycle and chromosome condensation and segregation are controlled by posttranslational protein modifications such as phosphorylation and SUMOylation. However, how SUMO isopeptidases (SENP) regulate cell mitotic procession is largely unknown. Here, we demonstrate that precise phosphorylation of SENP3 during mitosis suppresses SENP3 deSUMOylation activity towards chromosome-associated proteins, including topoisomerase IIα (TopoIIα). Cyclin B-dependent kinases 1 and protein phosphatase 1α were identified as the kinase and phosphatase in control of mitotic SENP3 phosphorylation, respectively...
May 1, 2018: Cancer Research
Wenfei Cai, Ting Hu, Amr M Bakry, Zhaomin Zheng, Yidong Xiao, Qilin Huang
The differences between ultrasonic and non-ultrasonic approaches in synthesizing Lignosus rhinocerotis polysaccharide-selenium nanoparticles (LRP-SeNPs) were compared in terms of size, morphology, stability and antioxidant activity by UV-VIS, FT-IR, X-ray diffraction (XRD), dynamic light scattering (DLS), transmission electron microscopy (TEM), and energy dispersive X-ray (EDX) with high resolution TEM. Results indicated that the SeNPs were associated with the LRP macromolecules in a physical adsorption pattern without breaking chemical bonds, and the ultrasonic treatment reduced the size of SeNPs, narrowed the size distribution as well as improved the stability...
April 2018: Ultrasonics Sonochemistry
Sweety A Wadhwani, Utkarsha U Shedbalkar, Richa Singh, Balu A Chopade
Synthesis of nanoparticles is an enzymatic reduction process in microorganisms. In the present study, a protein, lignin peroxidase has been purified by DEAE-Cellulose anion exchange chromatography and Biogel P-150 gel filtration chromatography from the cell suspension of Acinetobacter sp. SW30 responsible for the synthesis of gold nanoparticles (AuNP) and selenium nanoparticles (SeNP). The purified fraction has a specific activity of 29.4U/mg/min with 959 fold purification. Native and SDS PAGE confirmed that purified lignin peroxidase is monomeric enzyme with 97...
April 2018: Enzyme and Microbial Technology
Punnida Nonsuwan, Songchan Puthong, Tanapat Palaga, Nongnuj Muangsin
We proudly present the first organic/inorganic hybrid pullulan/SeNPs hybrid microflower material obtained using a simple and bio-inspired strategy. The chemical structures of pullulan, folic acid decorated cationic pullulan (FA-CP) were designed for stabilizing selenium nanoparticles (SeNPs). SeNPs stabilized by FA-CP hybrid microflowers were observed after the addition of a cysteine hydrochloride solution into the solution mixture of Na2 SeO3 and FA-CP. We suggested that the concentrations of cysteine and FA-CP were the key factors for the formation of flower-like structure...
March 15, 2018: Carbohydrate Polymers
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