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https://www.readbyqxmd.com/read/28734194/high-yield-one-pot-production-of-18-f-fch-via-a-modified-tracerlab-fxfn-module
#1
Ya-Yao Huang, Chia-Ling Tsai, Hsiang-Ping Wen, Kai-Yuan Tzen, Ruoh-Fen Yen, Chyng-Yann Shiue
INTRODUCTION: [(18)F]Fluoromethylcholine ([(18)F]FCH) is a potent tumors imaging agent. In order to fulfill the demand of pre-clinical and clinical studies, we have developed an automated high yield one-pot synthesis of this potent tumors imaging agent. METHODS: [(18)F]FCH was synthesized using a modified TRACERlab FxFN module. Briefly, dibromomethane (10% in CH3CN) was fluorinated with K[(18)F]/K 2.2.2 in a glassy carbon reaction vessel at 120°C for about 5min to generate [(18)F]fluorobromomethane ([(18)F]FBM)...
July 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28729778/effect-of-contrast-enhanced-ultrasound-on-differential-diagnosis-of-intrahepatic-cholangiocarcinoma-and-arterial-phase-enhanced-hepatic-inflammatory-lesions
#2
Shanshan Yin, Qiuli Cui, Kun Yan, Wei Yang, Wei Wu, Liping Bao, Minhua Chen
OBJECTIVE: To investigate differential diagnosis between intrahepatic cholangiocarcinoma (ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound (CEUS). METHODS: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve (TIC), including the arrival time, peak intensity (PI) in the lesions, the starting time for washout, and the intensity difference at 3 min (ΔI3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28729388/effects-of-acute-hypoxia-on-human-cognitive-processing-a-study-using-erps-and-seps
#3
Hiroki Nakata, Tadayoshi Miyamoto, Shigehiko Ogoh, Ryusuke Kakigi, Manabu Shibasaki
Although hypoxia has the potential to impair the cognitive function, the effects of acute hypoxia on the high-order brain function (executive and/or inhibitory processing) and somatosensory ascending processing remain unknown. We tested the hypothesis that acute hypoxia impairs both motor executive and inhibitory processing and somatosensory ascending processing. Fifteen healthy subjects performed two sessions (Sessions 1 and 2) consisting of electroencephalographic event-related potentials (ERPs) with somatosensory Go/No-go paradigms and somatosensory-evoked potentials (SEPs) under two conditions (hypoxia and normoxia) on different days...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28729179/global-regression-model-for-moisture-content-determination-using-near-infrared-spectroscopy
#4
Matthieu Clavaud, Yves Roggo, Klara Degardin, Pierre-Yves Sacré, Philippe Hubert, Eric Ziemons
Near-infrared (NIR) global quantitative models were evaluated for the moisture content (MC) determination of three different freeze-dried drug products. The quantitative models were based on 3822 spectra measured on two identical spectrometers to include variability. The MC, measured with the reference Karl Fischer (KF) method, were ranged from 0.05% to 4.96%. Linear and non-linear regression models using Partial Least Square (PLS), Decision Tree (DT), Bayesian Ridge Regression (Bayes-RR), K-Nearest Neighbors (KNN), and Support Vector Regression (SVR) algorithms were created and evaluated...
July 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28724054/effects-of-a-structured-education-program-on-glycemic-control-in-type-1-diabetes
#5
Ana Paula F Pacheco, Simone van de Sande-Lee, Rita de Cássia B Sandoval, Sônia Batista, Jefferson L B Marques
Objective: Diabetes mellitus is associated with significant morbidity and mortality, and education is known to play a key role in managing this disease. This study addresses the effects of a structured education program (SEP) on self-care in subjects with type 1 diabetes mellitus (T1DM). The aim was to evaluate the effect of a SEP on glycemic control, knowledge, and skills associated with diabetes care in subjects with T1DM. Subjects and methods: A total of 47 adults with T1DM were followed up for 20 months (32 participated in the SEP and 15 served as a control group)...
July 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28720218/pesticide-analysis-in-coffee-leaves-using-a-quick-easy-cheap-effective-rugged-and-safe-approach-and-liquid-chromatography-tandem-mass-spectrometry-optimization-of-the-clean-up-step
#6
Maria Teresa Salles Trevisan, Robert Wyn Owen, Pau Calatayud-Vernich, Andrea Breuer, Yolanda Picó
An analytical method using a quick, easy, cheap, effective, rugged and safe (QuEChERS) procedure for multi-residue determination of 52 pesticides in coffee leaf extractshas been developed and validated according to SANTE/11945/2015 guidelines. Different sorbent combinations for dispersive solid phase extraction (d-SPE) clean-up as well as dispersive liquid-liquid microextraction (DLLME) were tested. The relative standard deviations (RSDs) for the recovery of 87-94% of pesticides added to coffee leaf extracts,was ≤20% for samples spiked at concentrations up to 50ng*g(-1) depending on the clean-up procedures...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28719456/warning-criteria-for-intraoperative-neurophysiologic-monitoring
#7
Quanmeng Liu, Qinzhou Wang, Hongen Liu, William K K Wu, Matthew T V Chan
PURPOSE OF REVIEW: Intraoperative changes in somatosensory (SEP) and motor evoked potentials (MEPs) may indicate potential injury to the spinal cord and will require timely intervention to prevent permanent damage. This review focuses on the validity of currently recommended warning criteria for intraoperative evoked potential monitoring. RECENT FINDINGS: Current guideline recommends a decrease in SEP amplitude by 50% and MEP amplitude by 50-100% as warning signals for injury to the ascending sensory and descending motor pathway, respectively...
July 15, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28715464/impact-of-an-implicit-social-skills-training-group-in-children-with-autism-spectrum-disorder-without-intellectual-disability-a-before-and-after-study
#8
Jokthan Guivarch, Veena Murdymootoo, Sara-Nora Elissalde, Xavier Salle-Collemiche, Sophie Tardieu, Elisabeth Jouve, François Poinso
INTRODUCTION: Children with Autism Spectrum Disorders (ASDs) have problems with social skills. Social skills training groups are among the proposed therapeutic strategies, but their efficacy still needs to be evaluated. OBJECTIVE: To evaluate the efficacy of an implicit social skills training group in children with ASDs without intellectual disability. METHODS: A before-and-after study of children with ASD without intellectual disability was conducted in a child psychiatry day hospital, where they participated in an implicit group with cooperative games...
2017: PloS One
https://www.readbyqxmd.com/read/28709705/phase-ii-trial-of-neoadjuvant-chemotherapy-followed-by-chemoradiation-in-locally-advanced-cervical-cancer
#9
Carla Rameri Alexandre Silva de Azevedo, Luiz Cláudio Santos Thuler, Maria Júlia Gonçalves de Mello, Jurema Telles de Oliveira Lima, Ana Luiza Fassizoli da Fonte, Diógenes Fernando Santos Fontão, Vandré Cabral Gomes Carneiro, Tien Man Cabral Chang, Carlos Gil Ferreira
OBJECTIVE: Cervical cancer is a global public health challenge. Since 1999, platin based chemoradiation (CRT) is the standard treatment for those patients with locally advanced disease. However, this population still has a dismal prognosis and, alternatives approaches such as adjuvant chemotherapy are controversial, especially because of increased toxicity. Neoadjuvant chemotherapy (NACT) could be an option for more intensive treatment with manageable toxicity. METHODS: A phase II, prospective, non-randomized trial was conducted at a reference center in Recife, Brazil...
July 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28707620/a-quechers-based-sample-preparation-method-for-the-analysis-of-5-nitroimidazoles-in-bovine-milk-by-hplc-dad
#10
Tomasz Tuzimski, Tomasz Rejczak
In this study, a simple, cost-effective, and sensitive HPLC diode-array detection method was developed for thesimultaneous determination of six different 5-nitroimidazoles [metronidazole, 2-hydroxymethyl-1-methyl-5-nitro-(1)H-imidazole, dimetridazole (DMZ), ronidazole, ornidazole, and ipronidazole] in bovine milk samples. A QuEChERS-based sample preparation procedure was optimized by evaluating different cleanup sorbents, including zirconium-based sorbents (Z-Sep and Z-Sep+), C18, and primary–secondary amine (PSA), as well as EMR-Lipid cleanup solution...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28702751/complexes-of-gastrin-with-in-3-ru-3-or-ga-3-ions-are-not-recognised-by-the-cholecystokinin-2-receptor
#11
Marie Laval, Kathryn M Marshall, John Sachinidis, Andrew Scott, Mal Eutick, Graham S Baldwin
The peptide hormone gastrin (Gamide) binds trivalent metal ions, including indium (In), ruthenium (Ru) and gallium (Ga), with high affinity. Complexes of gastrin with chelated isotopes of In and Ga have previously been used for the location of tumours expressing the cholecystokinin 2 receptor (CCK2R). The aim of the present study was to purify the complexes of Gamide with radioactive isotopes of In, Ru or Ga and to investigate their ability to bind to the CCK2R. The radioactive Gamide complexes were purified on Sep-Pak C18 cartridges or by anion exchange HPLC...
July 12, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28697504/effects-of-a-training-program-involving-body-cooling-on-physical-and-cognitive-capacities-and-quality-of-life-in-multiple-sclerosis-patients-a-pilot-study
#12
Benoit Gonzales, Gilles Chopard, Benjamin Charry, Eric Berger, Julien Tripard, Eloi Magnin, Alain Groslambert
OBJECTIVE: Two methods using exercise and body cooling could influence the well-being of patients with multiple sclerosis (PwMS). The aim of this study was to determine whether wearing a cooling vest during a physical training program could increase the cognitive and physical capacities and quality of life in PwMS. METHODS: Eighteen PwMS (49.6 ± 8 years; Expanded Disability Status Score 5.0 ± 1.0) were randomly assigned to a cooling or control group. PwMS underwent a 7-week physical training program...
July 12, 2017: European Neurology
https://www.readbyqxmd.com/read/28693440/serum-lactate-level-and-mortality-in-metformin-associated-lactic-acidosis-requiring-renal-replacement-therapy-a-systematic-review-of-case-reports-and-case-series
#13
Hung-Chieh Yeh, I-Wen Ting, Ching-Wei Tsai, Jenn-Yu Wu, Chin-Chi Kuo
BACKGROUND: The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with MALA requiring RRT. METHODS: We searched PubMed/Medline and EMBASE from inception to Sep 2014 and applied predetermined exclusion criteria. Case-level data including case's demographics and clinical information related to MALA were abstracted...
July 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28692736/spatial-entropy-pursuit-for-fast-and-accurate-perimetry-testing
#14
Derk Wild, Serife Seda Kucur, Raphael Sznitman
Purpose: To propose a static automated perimetry strategy that increases the speed of visual field (VF) evaluation while retaining threshold estimate accuracy. Methods: We propose a novel algorithm, spatial entropy pursuit (SEP), which evaluates individual locations by using zippy estimation by sequential testing (ZEST) but additionally uses neighboring locations to estimate the sensitivity of related locations. We model the VF with a conditional random field (CRF) where each node represents a location estimate that depends on itself as well as its neighbors...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28683759/intravenous-neutralization-of-vascular-endothelial-growth-factor-reduces-vascular-function-permeability-of-the-ovary-and-prevents-development-of-ohss-like-symptoms-in-rhesus-monkeys
#15
C V Bishop, D M Lee, O D Slayden, X Li
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with elevated serum VEGFA following chorionic gonadotropin (hCG) exposure in controlled ovarian stimulation (COS) cycles in women. In this study, we tested the effect of intravenous VEGFA neutralization on OHSS-like symptoms and vascular function in rhesus macaques during COS cycles. METHODS: Monkeys (n = 8) were treated with 3 COS protocols and assigned randomly to groups as follows: 1) COS alone (Control, n = 5); 2) COS + VEGF mAb Avastin 19 ± 5 h before hCG (Avastin pre-hCG; n = 6); 3) COS + Avastin 3-4 days post-hCG (Avastin post-hCG; n = 4); 4) COS + Simulated Early Pregnancy (SEP n = 3); or 5) COS + SEP + Avastin (SEP + Avastin n = 3)...
July 6, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28680047/temporal-variation-in-associations-between-temperature-and-years-of-life-lost-in-a-southern-china-city-with-typical-subtropical-climate
#16
Guoxing Li, Jing Huang, Guozhang Xu, Xiaochuan Pan, Xujun Qian, Jiaying Xu, Yan Zhao, Tao Zhang, Qichen Liu, Xinbiao Guo, Tianfeng He
Though some studies have explored the association between temperature and years of life lost (YLL), limited evidence is available regarding the effect of temporal variation on the temperature-YLL relationship, especially in developing countries. We explored temporal variation in the associations between temperature and YLL before and after 2013 heat waves (period I: Jan 2008 to Sep 2013, period II: Oct 2013 to Dec 2015) in Ningbo, a southern China city with typical subtropical climate. The heat associations showed an increasing trend...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679435/associations-between-the-physical-activity-levels-of-fathers-and-their-children-at-20%C3%A2-months-3-5-and-five-years-of-age
#17
Adam D Walsh, David Crawford, Adrian J Cameron, Karen J Campbell, Kylie D Hesketh
BACKGROUND: Early childhood (under five years of age) is a critical developmental period when children's physical activity behaviours are shaped and when physical activity patterns begin to emerge. Physical activity levels track from early childhood through to adolescence with low levels of physical activity associated with poorer health. The aims of this study were to examine cross-sectional and longitudinal associations between the physical activity levels of fathers and their children at the ages of 20 months, 3...
July 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28679412/impact-of-body-size-nutrition-and-socioeconomic-position-in-early-life-on-the-epigenome-a-systematic-review-protocol
#18
Jane Maddock, Wahyu Wulaningsih, Rebecca Hardy
BACKGROUND: Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a range of later life health outcomes. Epigenetic regulation is one mechanism through which these early life factors may impact later life health. The aim of this review protocol is to outline procedures to document the influence of body size, nutrition and SEP in early life on the epigenome. METHODS: MEDLINE, Embase and BIOSIS will be systematically searched using pre-defined keywords...
July 5, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28675279/-benign-esophageal-strictures-endoscopic-treatment-options
#19
Michael Drepper, Philippe Bichard, Jean-Louis Frossard
Bening strictures of the esophagus are a frequently encountered problem in endoscopy. Dilation by Savary-Gilliard dilators or balloon dilators is the first line treatment and relieves dysphagia in about 75 % of cases. Complex strictures are at higher risk of treatment failure than simple ones and are considered as refractory after repetitive unsuccessful dilations. Adjunction of locally injected corticoids favors outcome in strictures of peptic origin. Further treatment options of refractory strictures are endoscopic incision therapy in short ones and temporary self expandable metallic (SEMS), plastic (SEPS) or biodegradable stent insertion in complex ones...
August 31, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28673764/how-to-assess-sensory-recovery-after-breast-reconstruction-surgery
#20
Helena K Puonti, Taina A Broth, Seppo O Soinila, Helena K Hallikainen, Satu K Jääskeläinen
BACKGROUND: We evaluated clinical against psychophysical (tactile and thermal quantitative sensory test [QST]), neurophysiologic (somatosensory evoked potential [SEP]), and epithelial nerve fiber density (ENFD) examinations in detection and follow-up of sensory alterations after breast reconstruction done with or without nerve anastomoses. PATIENTS AND METHODS: In a prospective 2-year follow-up design, 56 breast cancer patients underwent innervated and 20 patients noninnervated free rectus abdominis muscle-sparing flap (ms-TRAM) breast reconstruction...
April 29, 2017: Clinical Breast Cancer
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