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https://www.readbyqxmd.com/read/29241143/perceptions-about-supervised-injection-facilities-among-people-who-inject-drugs-in-philadelphia
#1
Robert E Harris, Jessica Richardson, Rosemary Frasso, Evan D Anderson
BACKGROUND: People who inject drugs (PWID) are at high risk for infectious diseases, skin and soft tissue infections, and overdose. However, these harms are all avoidable when sterile injection equipment, hygienic places to inject, and medical care are accessible. Unfortunately, many PWID in the U.S lack these resources. The most vulnerable are forced to inject in public spaces, where individual risks are high and communal harms are sometimes many. Supervised Injection Facilities (SIFs) are an established intervention for reducing these harms...
December 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29236303/impact-of-antimicrobial-stewardship-program-on-hospitalized-patients-at-the-intensive-care-unit-a-prospective-audit-and-feedback-study
#2
Maher R Khdour, Hussein O Hallak, Mamoon Al-Deyab, Mowafq A Nasif, Aliaa M Khalili, Ahamad A Dallashi, Mohammad B Khofash, Michael G Scott
AIMS: Inappropriate use of antibiotics is one of the most important factors contributing to the emergence of drug resistant pathogens. The purpose of this study was to measure the clinical impact of Antimicrobial Stewardship Program (ASP) interventions on hospitalized patients at the Intensive care unit at Palestinian Medical Complex. METHODS: A prospective audit with intervention and feedback by ASP team within 48-72h of antibiotic administration began in Sep, 2015...
December 13, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29236094/hospital-perceptions-of-medicare-s-sepsis-quality-reporting-initiative
#3
Ian J Barbash, Kimberly J Rak, Courtney C Kuza, Jeremy M Kahn
BACKGROUND: In October 2015, the Centers for Medicare and Medicaid Services (CMS) implemented the Sepsis CMS Core Measure (SEP-1) program, requiring hospitals to report data on the quality of care for their patients with sepsis. OBJECTIVE: We sought to understand hospital perceptions of and responses to the SEP-1 program. DESIGN: A thematic content analysis of semistructured interviews with hospital quality officials. SETTING: A stratified random sample of short-stay, nonfederal, general acute care hospitals in the United States...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29234452/genetic-variations-of-cholesteryl-ester-transfer-protein-and-diet-interactions-in-relation-to-lipid-profiles-and-coronary-heart-disease-a-systematic-review
#4
REVIEW
Parvin Mirmiran, Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S Daneshpour, Bahar Sedaghati-Khayat, Fereidoun Azizi
Data on diet-genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet on cholesteryl ester transfer protein (CETP) polymorphisms in relation to metabolic traits. Data were collected through studies published between 2000 and SEP. 2016 using five electronic databases. The quality of eligible studies was assessed using a 12-item quality checklist, derived from the STrengthening the REporting of Genetic Association Studies (STREGA) statement...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29230516/-the-distribution-of-cardiovascular-risk-factors-in-employees-from-small-and-medium-sized-enterprises-in-germany
#5
Andrea Kaifie, Thomas Kraus
BACKGROUND: The German Prevention Act, the main parts of which came into force on 25 July 2015, encourages health promotion and prevention programs for people in their living environment. Through this act, preventive measures could reach employees at work that hardly seek medical services. This is of importance since employees with a low occupational position often show risk factors that increase morbidity and mortality. METHODS: In this study, clinical data from n = 2280 employees from small and medium sized enterprises (SME) were analyzed for economic sector, sex, socioeconomic position (SEP), economic sector cardiovascular risk factors, musculoskeletal and psychological diseases...
December 11, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29229431/altered-neurocognitive-processing-of-tactile-stimuli-in-patients-with-complex-regional-pain-syndrome-crps
#6
Anoop Kuttikat, Valdas Noreika, Srivas Chennu, Nicholas Shenker, Tristan Bekinschtein, Christopher A Brown
Chronic pain in CRPS has been linked to tactile misperceptions and deficits in somatotopic representation of the affected limb. Here, we identify altered cognitive processing of tactile stimuli in CRPS patients that we propose marks heterogeneity in tactile decision-making mechanisms. In a case-control design, we compared middle and late-latency somatosensory-evoked potentials (SEPs) in response to pseudo-randomised mechanical stimulation of the digits of both hands (including CRPS-affected and non-affected sides) between 13 CRPS patients and 13 matched healthy controls...
December 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29229335/determination-of-organophosphorus-flame-retardants-in-fish-by-freezing-lipid-precipitation-solid-phase-extraction-and-gas-chromatography-mass-spectrometry
#7
Yin-E Liu, Li-Qian Huang, Xiao-Jun Luo, Xiao-Xin Tan, Chen-Chen Huang, Pablo Zapata Corella, Bi-Xian Mai
An analytical method has been developed for measuring 12 organophosphorus flame retardants (PFRs) in fish tissue samples. After the Soxhlet extraction of PFRs with dichloromethane. The experimental parameters of the clean-up were systematically optimized. Methanol was found to be a more effective solvent than acetonitrile used in freezing-lipid precipitation. Methanol (5%) in ultrapure water, was finally selected to perform solid-phase extraction (SPE, Oasis HLB cartridge), with mean lipid removal efficiency of 94% after freezing-lipid precipitation...
December 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29223115/immobilization-of-hexavalent-chromium-in-contaminated-soils-using-biochar-supported-nanoscale-iron-sulfide-composite
#8
Honghong Lyu, Hang Zhao, Jingchun Tang, Yanyan Gong, Yao Huang, Qihang Wu, Bin Gao
Biochar supported carboxymethyl cellulose (CMC)-stabilized nanoscale iron sulfide (FeS) composite (CMC-FeS@biochar) was prepared and tested for immobilization of hexavalent chromium Cr(VI) in soil. Results of UV-vis and transmission electron microscopy (TEM) showed that the backbone of biochar suppressed the aggregation of FeS, resulting in smaller particle size and more sorption sites than bare FeS. The composite at a dosage of 2.5 mg per gram soil displayed an enhanced Cr(VI) immobilization efficiency (a 94...
December 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29220580/the-influence-of-adiposity-and-acute-exercise-on-circulating-hepatokines-in-normal-weight-and-overweight-obese-men
#9
Jack A Sargeant, Guruprasad P Aithal, Toshinari Takamura, Hirofumi Misu, Hiroaki Takayama, Jessica A Douglas, Mark C Turner, David J Stensel, Myra A Nimmo, David R Webb, Thomas Yates, James A King
Hepatokines are liver-secreted proteins with potential to influence glucose regulation and other metabolic parameters. This study investigated differences in adiposity status on five novel hepatokines and characterised their response to acute moderate-intensity exercise in groups of normal weight and overweight/obese men. Twenty-two men were recruited into normal weight and overweight/obese groups (BMI: 18.5 to 24.9 and 25.0 to 34.9 kg∙m<sup>-2</sup>). Each completed two experimental trials, exercise and control...
December 8, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29217592/loss-of-lofsep-transcription-factor-function-converts-spikelet-to-leaf-like-structures-in-rice
#10
Di Wu, Wanqi Liang, Wanwan Zhu, Mingjiao Chen, Cristina Ferrandiz, Rachel A Burton, Ludovico Dreni, Dabing Zhang
SEPALLATA (SEP)-like genes, which encode a subfamily of MADS-box transcription factors, are essential for specifying floral organ and meristem identity in angiosperms. Rice (Oryza sativa L.) has five SEP-like genes with partial redundancy and overlapping expression domains, yet their functions and evolutionary conservation are only partially known. Here, we describe the biological role of one of the SEP genes of rice, OsMADS5, in redundantly controlling spikelet morphogenesis. OsMADS5 belongs to the conserved LOFSEP subgroup along with OsMADS1 and OsMADS34...
December 7, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29217422/hyperbaric-oxygen-ameliorated-the-lesion-scope-and-nerve-function-in-acute-spinal-cord-injury-patients-a-retrospective-study
#11
Jie-Wen Tan, Fang Zhang, He-Jun Liu, Zhuo Li
OBJECTIVE: This is a retrospective study to assess the therapeutic effect of hyperbaric oxygen (HBO) in early treatment of acute spinal cord injury (SCI) using magnetic resonance imaging (MRI) and electrophysiology in diagnosing. METHODS: Forty acute SCI patients from Sun Yat-Sen Memorial Hospital who were assigned into HBO treatment were included during August 2013 to October 2014.The patients with adverse reactions or contraindications for HBO were assigned as controls...
December 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29216407/an-open-label-positron-emission-tomography-pet-study-to-evaluate-serotonin-transporter-occupancy-following-escalating-dosing-regimens-of-r-o-desmethylvenlafaxine-and-racemic-o-desmethylvenlafaxine
#12
W Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran
INTRODUCTION: SEP-227162 [R(-)-O-desmethylvenlafaxine] is an enantiomer of the venlafaxine metabolite O-desmethylvenlafaxine (ODV, Pristiq™, Wyeth). This study compared the serotonin transporter occupancy achieved by SEP-227162 and ODV, at daily doses of 25mg, 50mg, 100mg and 150mg using [11 C]DASB positron emission tomography (PET). METHODS: Sixteen healthy male subjects participated in one of four dose groups (N = 4 per group) during which they were administered two doses of the study drug (SEP-227162 or ODV)...
December 7, 2017: Synapse
https://www.readbyqxmd.com/read/29205640/presepsin-as-a-predictor-of-positive-blood-culture-among-newborns-suspected-sepsis
#13
Yukihide Miyosawa, Yohei Akazawa, Motoko Kamiya, Chizuko Nakamura, Yusuke Takeuchi, Mai Kusakari, Tomohiko Nakamura
BACKGROUND: Although the incidence of neonatal sepsis is decreasing, neonatal sepsis remains a severe life-threatening disease. No current biochemical marker can provide perfect diagnostic accuracy for neonatal sepsis. OBJECTIVES: We evaluated the accuracy of presepsin (P-SEP) as a novel biomarker of bacterial infection for neonatal sepsis diagnosis. METHODS: We prospectively studied newborns with sepsis (sepsis group n=13) during the first 30 days after birth and compared them with control preterm newborns (control group n=18)...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29202893/the-role-of-the-early-social-environment-on-epstein-barr-virus-infection-a-prospective-observational-design-using-the-millennium-cohort-study
#14
V Gares, L Panico, R Castagne, C Delpierre, M Kelly-Irving
Epstein-Barr virus (EBV) is a highly prevalent herpesvirus linked to infectious mononucleosis and several malignancies. This paper aims to study the association between children's early life social environment at 9 months and EBV infection at 3 years of age. METHODS: We used data on children included in the UK Millennium Cohort Study. We described the social environment using area-level and material factors as well as socioeconomic position (SEP) at 9 months. EBV was measured at 3 years of age (n = 12 457)...
December 5, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29201121/assessment-of-toxoplasma-seropositivity-in-children-suffering-from-anxiety-disorders
#15
Shahla Afsharpaiman, Mohammad Hossein Khosravi, Mojtaba Mahmoodinejad, Shahnaz Shirbazoo, Susan Amirsalari, Mohammad Torkaman, Shokoofeh Radfar
Objective: This study aimed to assess the seroprevalence of Toxoplasma gondii in children with anxiety disorders. Materials & Methods: This cross-sectional study was conducted between Sep 2012 and May 2013 in Pediatrics Clinic of Baqiyatallah Hospital, Tehran, Iran. Children were assessed clinically. Diagnosis of patients with anxiety disorders was based on DSM-4 system, performed by child psychiatrist. Then their anti-Toxoplasma antibodies were measured. A questionnaire was verbally administered to all individuals' parents including demographic information and questions about life style, family history, medical history, economic situation, residence, nutritional patterns and contact with animals...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29199825/unusual-aggregation-arrangement-of-eu-containing-polyoxometalate-hybrid-in-a-protic-ionic-liquid-with-improved-luminescence-property
#16
Nana Lei, Sijing Yi, Jiao Wang, Qintang Li, Xiao Chen
Hybridization of polyoxometalates (POMs) with cationic surfactants offers the opportunity to greatly improve their functionalities as well as processabilities. Here, a surfactant-encapsulated Eu-containing POM complex (SEP) was formed via electrostatic interaction between 1-octadecyl-3-methylimidazolium bromide (OB) and Na9(EuW10O36)•32H2O (EuW10). SEP was firstly self-assembled in a protic ionic liquid to prepare the soft aggregates to fundamentally avoid the fluorescence quenching by water molecules. The structures and photophysical properties of SEP or aggregates were investigated thoroughly by NMR and FTIR spectroscopy, optical and electron microscopy, small-angle X-ray scattering and fluorescence measurements...
December 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29197969/the-association-of-early-life-socioeconomic-position-on-breast-cancer-incidence-and-mortality-a-systematic-review
#17
REVIEW
Tomi F Akinyemiju, Joshua Demb, Monika A Izano, David H Rehkopf, Min-Lin Fang, Robert A Hiatt, Dejana Braithwaite
OBJECTIVES: We conducted a systematic review of the literature relating early life socioeconomic position (SEP) to breast cancer incidence and mortality from a critical period and life-course trajectory perspective. METHODS: PubMed, EMBASE and Web of Science were searched to identify cohort studies that evaluated the impact of early life SEP indicators on the incidence and/or mortality from breast cancer in adulthood. RESULTS: Nine distinct studies evaluated the relationship between early life SEP and breast cancer between 1990 and 2016...
December 2, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/29188390/a-survival-analysis-using-physique-adjusted-tumor-size-of-non-small-cell-lung-cancer
#18
Naoki Ozeki, Takayuki Fukui, Koji Kawaguchi, Shota Nakamura, Shuhei Hakiri, Taketo Kato, Akihiro Hirakawa, Kohei Yokoi
BACKGROUND: Differences in individual body sizes have not been well considered when analyzing the survival of patients with non-small cell lung cancer (NSCLC). We hypothesized that physique-adjusted tumor size is superior to actual tumor size in predicting the prognosis. METHODS: Eight hundred and forty-two patients who underwent R0 resection of NSCLC between 2005 and 2012 were retrospectively reviewed, and overall survival (OS) was evaluated. The physique-adjusted tumor size was defined as: x-adjusted tumor size = tumor size × mean value of x/individual value of x [x = height, weight, body surface area (BSA), or body mass index (BMI)]...
November 29, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29188250/honeycomb-patterned-hybrid-films-of-surfactant-encapsulated-polyoxometalates-by-a-breath-figure-method-and-its-electrocatalysis-for-bro3
#19
Li Zhang, Lei Chen, Shu-Xia Liu, Jian Gong, Qun Tang, Zhong-Min Su
In this paper, a sandwich type of polyoxophosphotungstate K7Na3[Cu4(H2O)2(PW9O34)2]·20H2O (abbr. Cu4(PW9)2) was selected as an active unit to construct inorganic/organic hybrid materials. The ordered honeycomb structure of the surfactant-encapsulated polyoxometalate (SEP) complex was successfully obtained by using a famous breath figure method. Cu4(PW9)2 maintains typical features as confirmed by IR spectra, magnetization hysteresis studies and UV-vis spectra. An investigation of the effects of the relative humidity on the morphology of the honeycomb structures demonstrated a wide generality and high reproducibility of the formation of self-organized honeycomb-patterned films...
November 30, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29186460/understanding-the-relation-between-socioeconomic-position-and-inflammation-in-post-menopausal-women-education-income-and-occupational-prestige
#20
Jolene Masters Pedersen, Esben Budtz-Jørgensen, Anneclaire De Roos, Lorena Garcia, Rikke Lund, Naja Hulvej Rod, Candyce Kroenke, Kei Hang Katie Chan, Simin Liu, Yvonne Michael
Background: The role of occupational prestige, a direct measure of the perceived status of job and job holder, in inflammation is unknown. To contribute to understanding the pathways by which socioeconomic position (SEP) is associated with inflammation, we aimed to estimate the direct effects of education, income and occupational prestige on C-reactive protein (CRP) and to describe the relationship between these markers and CRP. Methods: The study was based on 2026 post-menopausal women enrolled in the Women's Health Initiative-Observational Study...
December 1, 2017: European Journal of Public Health
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