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Gonzalez A MD Anderson ovarian cancer

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https://www.readbyqxmd.com/read/21913181/earlier-age-of-onset-of-brca-mutation-related-cancers-in-subsequent-generations
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Jennifer K Litton, Kaylene Ready, Huiqin Chen, Angelica Gutierrez-Barrera, Carol J Etzel, Funda Meric-Bernstam, Ana M Gonzalez-Angulo, Huong Le-Petross, Karen Lu, Gabriel N Hortobagyi, Banu K Arun
BACKGROUND: Women who are diagnosed with a deleterious mutation in either breast cancer (BRCA) gene have a high risk of developing breast and ovarian cancers at young ages. In this study, the authors assessed age at diagnosis in 2 generations of families with known mutations to investigate for earlier onset in subsequent generations. METHODS: Of the 132 BRCA-positive women with breast cancer who participated in a high-risk protocol at The University of Texas MD Anderson Cancer Center (Gen 2), 106 women could be paired with a family member in the previous generation (Gen 1) who was diagnosed with a BRCA-related cancer (either breast cancer or ovarian cancer)...
January 15, 2012: Cancer
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