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Penicillin anemia eosinophilia

Eric Macy, Eunis Ngor
Beta-lactam intolerance, most of which is not IgE or even immunologically mediated even though it is commonly called an "allergy," can be safely managed using the following seven steps: 1. Avoid testing, re-challenging, or desensitizing individuals with histories of beta-lactam associated toxic epidermal necrolysis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms syndrome, severe hepatitis, interstitial nephritis, or hemolytic anemia. 2. Avoid unnecessary antibiotic use, especially in the setting of viral infections...
August 2014: Clinical Reviews in Allergy & Immunology
K A Neftel, M Wälti, H K Schulthess, J Gubler
We have recently shown that high-dose intravenous therapy with penicillin-G always results in both sensitised lymphocytes and rise of anti-penicilloyl IgG antibodies. If penicillin-G is strictly given as freshly prepared bolus doses this sensitisation is prevented. In 193 patients, intravenous treatment with penicillin-G without special precautions (bolus doses stored up to 36 h at 4 degrees C or continuous infusions) led to 8.3% definite, 6.7% probable and 14.0% possible adverse reactions. In 116 patients treated exclusively with freshly dissolved doses, 0...
January 2, 1984: Klinische Wochenschrift
J R Ibister
No abstract text is available yet for this article.
December 1971: Review of Allergy
G I Glezer
No abstract text is available yet for this article.
April 1972: Antibiotiki
J P Isbister
No abstract text is available yet for this article.
May 15, 1971: Medical Journal of Australia
S M Worlledge
No abstract text is available yet for this article.
April 1969: Seminars in Hematology
D Lee, J M Dewdney, R G Edwards, K A Neftel, M Wälti
Sera from 125 patients receiving mean total doses of beta-lactam therapy of 215 g over a mean of 14 days were assayed by radioimmunoassay. Titres of anti-penicilloyl antibodies, expressed in arbitrary units of specific IgG per microliter of serum (u/microliter), ranged from undetectable (less than 3 u/microliter) to 1,650 u/microliter. There was a higher prevalence of elevated IgG levels in patients who developed haemolytic anaemia or neutropenia compared with patients with no adverse reactions but only in those patients who developed haemolytic anaemia were the antibody titres significantly higher...
1986: International Archives of Allergy and Applied Immunology
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