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https://www.readbyqxmd.com/read/28930866/p2x7r-blockade-prevents-nlrp3-inflammasome-activation-and-pancreatic-fibrosis-in-a-mouse-model-of-chronic-pancreatitis
#1
Gui-Xian Zhang, Man-Xue Wang, Wei Nie, Da-Wei Liu, Yi Zhang, Hong-Bin Liu
OBJECTIVES: The aim of this study was to investigate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in a mouse model of chronic pancreatitis (CP). METHODS: Chronic pancreatitis was induced by repeated intraperitoneal injections of 50 μg/kg cerulein for 6 weeks in mice. P2X7R antagonist oxidized ATP (OxATP) or brilliant blue G (BBG) was administered after the last cerulein injection for 2 weeks...
September 19, 2017: Pancreas
https://www.readbyqxmd.com/read/28930257/physicochemical-properties-antioxidant-and-cytotoxic-activities-of-crude-extracts-and-fractions-from-phyllanthus-amarus
#2
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lower levels of residual moisture (7.40%) and water activity (0.24) and higher contents of saponins, phenolics, flavonoids, and proanthocyanidins (1657...
June 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929027/the-role-of-polycarbonate-monomer-bisphenol-a-in-insulin-resistance
#3
Milos Pjanic
Bisphenol A (BPA) is a synthetic unit of polycarbonate polymers and epoxy resins, the types of plastics that could be found in essentially every human population and incorporated into almost every aspect of the modern human society. BPA polymers appear in a wide range of products, from liquid storages (plastic bottles, can and glass linings, water pipes and tanks) and food storages (plastics wraps and containers), to medical and dental devices. BPA polymers could be hydrolyzed spontaneously or in a photo- or temperature-catalyzed process, providing widespread environmental distribution and chronic exposure to the BPA monomer in contemporary human populations...
2017: PeerJ
https://www.readbyqxmd.com/read/28928397/atorvastatin-but-not-pravastatin-impairs-mitochondrial-function-in-human-pancreatic-islets-and-rat-%C3%AE-cells-direct-effect-of-oxidative-stress
#4
Francesca Urbano, Marco Bugliani, Agnese Filippello, Alessandra Scamporrino, Stefania Di Mauro, Antonino Di Pino, Roberto Scicali, Davide Noto, Agata Maria Rabuazzo, Maurizio Averna, Piero Marchetti, Francesco Purrello, Salvatore Piro
Statins are a class of drugs widely prescribed as frontline therapy for lowering plasma LDL-cholesterol in cardiovascular risk prevention. Several clinical reports have recently suggested an increased risk of type 2 diabetes associated with chronic use of these drugs. The pathophysiology of this effect remains to be fully elucidated but impaired β-cell function constitutes a potential mechanism. The aim of this study was to explore the effect of a chronic treatment with lipophilic and hydrophilic statins on β-cell function, using human pancreatic islets and rat insulin-secreting INS-1 cells; we particularly focused on the role of mitochondria and oxidative stress...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926852/endoscopic-management-of-chronic-pancreatitis-with-a-fully-covered-self-expanding-metal-stent-and-laser-lithotripsy
#5
Aleksey Novikov, Ming-Ming Xu, Amy Tyberg, Michel Kahaleh
No abstract text is available yet for this article.
September 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28925906/buxus-sempervirens-l-improves-streptozotocin-induced-diabetes-mellitus-in-rats
#6
Mohamed Eddouks, Mohammed Ajebli
BACKGROUND: Buxus sempervirens L. (Boxwood) is a medicinal plant used in Moroccan traditional medicine for diabetes treatment in Morocco. However; there is no experimental support of this ethnopharmacological use. METHODS: The present investigation aimed to study the antidiabetic and the preliminary phytochemical of the aqueous extract of the leaves of Buxus sempervirens (AELBS). AELBS (5 mg/kg) was administered by gavage to normal and streptozotocin-induced diabetic rats and blood glucose levels were measured for 6 hours (acute study) and 15 days (chronic study)...
September 18, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28922443/primary-hepatic-lymphoma-complicated-by-a-hepatic-inflammatory-pseudotumor-and-tumor-forming-pancreatitis
#7
Rena Kaneko, Hiroyuki Mitomi, Natsuko Nakazaki, Yuichiro Yano, Masazumi Ogawa, Yuzuru Sato
BACKGROUND: Hepatic inflammatory pseudotumor (IPT) is considered to be benign in biological behavior, and its malignant transformation is extremely rare. There has only been one published case of primary hepatic lymphoma complicated by hepatic IPT. CASE PRESENTATION: A 73-year-old man presented with obstructive jaundice and a pancreatic head mass. Histology of the mass revealed chronic pancreatitis with lymphoid follicle formation, leading to a diagnosis of a suspicion of follicular pancreatitis...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28921377/basophils-activated-via-tlr-signaling-may-contribute-to-pathophysiology-of-type-1-autoimmune-pancreatitis
#8
Masato Yanagawa, Kazushige Uchida, Yugo Ando, Takashi Tomiyama, Takashi Yamaguchi, Tsukasa Ikeura, Toshiro Fukui, Akiyoshi Nishio, Yoshiko Uemura, Takayuki Miyara, Hiroyuki Okamoto, Souhei Satoi, Kazuichi Okazaki
BACKGROUND: Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. In this study, we investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP. METHODS: By using immunohistochemistry, we investigated basophils in pancreatic tissue from 13 patients with type 1 AIP and examined expression of toll-like receptors (TLRs) by these cells...
September 18, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28921009/radiation-overexposure-from-repeated-ct-scans-in-young-adults-with-acute-abdominal-pain
#9
Massimo Tonolini, Elena Valconi, Angelo Vanzulli, Roberto Bianco
PURPOSE: The purpose of this study is to assess the dose of ionizing radiation caused by repeated CT scans performed to investigate non-traumatic acute abdominal conditions in young adults. METHODS: Over 26 months, we collected a cohort of patients aged 18 to 45 years who were subject to at least one urgent contrast-enhanced abdomen/pelvis CT. Patients affected with urolithiasis, HIV infection, tumors, and vascular and chronic inflammatory bowel diseases were excluded...
September 18, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28919305/magnolol-protects-pancreatic-%C3%AE-cells-against-methylglyoxal-induced-cellular-dysfunction
#10
Kwang Sik Suh, Suk Chon, Woon-Won Jung, Eun Mi Choi
Chronic hyperglycemia aggravates insulin resistance, in part due to increased formation of advanced glycation end-products (AGEs). Methylglyoxal (MG), a major precursor of AGEs, accumulates abnormally in various tissues and organs and participates in oxidative damage. We investigated the insulinotropic benefits of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, in pancreatic β-cells exposed to MG in vitro. When exposed to cytotoxic levels of MG for 48 h, RIN-m5F β-cells exhibited a significant loss of viability and impaired insulin secretion, whereas pretreatment with magnolol protected against MG-induced cell death and decreased insulin secretion...
September 15, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28919082/diabetes-mellitus-and-obesity-as-risk-factors-for-pancreatic-cancer
#11
Guido Eibl, Zobeida Cruz-Monserrate, Murray Korc, Maxim S Petrov, Mark O Goodarzi, William E Fisher, Aida Habtezion, Aurelia Lugea, Stephen J Pandol, Phil A Hart, Dana K Andersen
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030...
September 11, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28918191/development-and-validation-of-a-chronic-pancreatitis-prognosis-score-in-2-independent-cohorts
#12
Georg Beyer, Ujjwal M Mahajan, Christoph Budde, Thomas J Bulla, Thomas Kohlmann, Louise Kuhlmann, Kerstin Schütte, Ali A Aghdassi, Eckhard Weber, Ulrich Weiss, Asbjørn M Drewes, Søren S Olesen, Markus M Lerch, Julia Mayerle
BACKGROUND & AIMS: The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes. METHODS: We performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe, from January 2011 through April 2014. We analyzed correlations between clinical, laboratory, and imaging data with number of hospital readmissions and in-hospital days over the next 12 months; the parameters with the highest degree of correlation were to develop 3-stage chronic pancreatitis prognosis score (COPPS)...
September 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28916969/comparison-of-platelet-lymphocyte-ratio-and-ca-19-9-in-differentiating-benign-from-malignant-head-masses-in-patients-with-chronic-pancreatitis
#13
Shanavas Kakkat, Ramesh Rajan, R S Sindhu, Bonny Natesh, S Raviram
INTRODUCTION: Pancreatic head ductal adenocarcinoma (PDAC) and inflammatory head masses (IHM) related to chronic pancreatitis are often difficult to differentiate. PDAC produces significant inflammatory response with resultant lymphopenia and thrombocytosis. The prognostic role of platelet-lymphocyte ratio (PLR) as a tumor marker has been defined. We aimed to find the role of PLR as a diagnostic marker for PDAC in differentiating benign head mass comparing with carbohydrate antigen 19-9 (CA 19-9)...
September 16, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28915699/biological-effects-and-epidemiological-consequences-of-arsenic-exposure-and-reagents-that-can-ameliorate-arsenic-damage-in-vivo
#14
REVIEW
Chinthalapally V Rao, Sanya Pal, Altaf Mohammed, Mudassir Farooqui, Mark P Doescher, Adam S Asch, Hiroshi Y Yamada
Through contaminated diet, water, and other forms of environmental exposure, arsenic affects human health. There are many U.S. and worldwide "hot spots" where the arsenic level in public water exceeds the maximum exposure limit. The biological effects of chronic arsenic exposure include generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage, epigenetic DNA modification, induction of genomic instability, and inflammation and immunomodulation, all of which can initiate carcinogenesis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915633/selection-of-optimal-molecular-targets-for-tumor-specific-imaging-in-pancreatic-ductal-adenocarcinoma
#15
Willemieke S Tummers, Arantza Farina-Sarasqueta, Martin C Boonstra, Hendrica A Prevoo, Cornelis F Sier, Jan S Mieog, Johannes Morreau, Casper H van Eijck, Peter J Kuppen, Cornelis J van de Velde, Bert A Bonsing, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg
Discrimination of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) or peritumoral inflammation is challenging, both at preoperative imaging and during surgery, but it is crucial for proper therapy selection. Tumor-specific molecular imaging aims to enhance this discrimination and to help select and stratify patients for resection. We evaluated various biomarkers for the specific identification of PDAC and associated lymph node metastases. Using immunohistochemistry (IHC), expression levels and patterns were investigated of integrin αvβ6, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), Cathepsin E (Cath E), epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), thymocyte differentiation antigen 1 (Thy1), and urokinase-type plasminogen activator receptor (uPAR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914984/hypercalcemic-disorders-in-children
#16
REVIEW
Victoria J Stokes, Morten F Nielsen, Fadil M Hannan, Rajesh V Thakker
Hypercalcemia is defined as a serum calcium concentration that is greater than 2 standard deviations above the normal mean, which in children may vary with age and sex, reflecting changes in the normal physiology at each developmental stage. Hypercalcemic disorders in children may present with hypotonia, poor feeding, vomiting, constipation, abdominal pain, lethargy, polyuria, dehydration, failure to thrive and seizures. In severe cases renal failure, pancreatitis and reduced consciousness may also occur and older children and adolescents may present with psychiatric symptoms...
September 15, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28914856/-the-russian-consensus-on-the-diagnosis-and-treatment-of-chronic-pancreatitis-enzyme-replacement-therapy
#17
I E Khatkov, I V Maev, D S Bordin, Yu A Kucheryavyi, S R Abdulkhakov, S A Alekseenko, E I Alieva, R B Alikhanov, I G Bakulin, A Yu Baranovsky, E V Beloborodova, E A Belousova, I M Buriev, E V Bystrovskaya, S V Vertyankin, L V Vinokurova, E I Galperin, A V Gorelov, V B Grinevich, M V Danilov, V V Darvin, E A Dubtsova, T G Dyuzheva, V I Egorov, M G Efanov, N V Zakharova, V E Zagainov, V T Ivashkin, R E Izrailov, N V Korochanskaya, E A Kornienko, V L Korobka, N Yu Kokhanenko, M A Livzan, I D Loranskaya, K A Nikolskaya, M F Osipenko, A V Okhlobystin, V D Pasechnikov, E Yu Plotnikova, S I Polyakova, O A Sablin, V I Simanenkov, N I Ursova, V V Tsvirkun, V V Tsukanov, A V Shabunin
Pancreatology Club Professional Medical Community, 1A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow; 3Kazan State Medical University, Ministry of Health of Russia, Kazan; 4Kazan (Volga) Federal University, Kazan; 5Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk; 6Morozov City Children's Clinical Hospital, Moscow Healthcare Department, Moscow; 7I...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28913878/do-pancreatic-cancer-and-chronic-pancreatitis-share-the-same-genetic-risk-factors-a-pancreatic-disease-research-pandora-consortium-investigation
#18
Daniele Campa, Manuela Pastore, Gabriele Capurso, Thilo Hackert, Milena Di Leo, Jakob R Izbicki, Kay-Tee Khaw, Domenica Gioffreda, Juozas Kupcinskas, Claudio Pasquali, Peter Macinga, Rudolf Kaaks, Serena Stigliano, Petra H Peeters, Timothy J Key, Renata Talar-Wojnarowska, Pavel Vodicka, Roberto Valente, Yogesh K Vashist, Roberto Salvia, Ioannis Papaconstantinou, Yasuhiro Shimizu, Chiara Valsuani, Carlo Federico Zambon, Maria Gazouli, Irena Valantiene, Willem Niesen, Beatrice Mohelnikova-Duchonova, Kazuo Hara, Pavel Soucek, Ewa Malecka-Panas, H Bas Bueno-De-Mesquita, Theron Johnson, Herman Brenner, Francesca Tavano, Paola Fogar, Hidemi Ito, Cosimo Sperti, Katja Butterbach, Anna Latiano, Angelo Andriulli, Giulia Martina Cavestro, Olivier R C Busch, Frederike Dijk, William Greenhalf, Keitaro Matsuo, Carlo Lombardo, Oliver Strobel, Anna-Katharina König, Katarina Cuk, Hendrik Strothmann, Verena Katzke, Maurizio Cantore, Andrea Mambrini, Martin Oliverius, Raffaele Pezzilli, Stefano Landi, Federico Canzian
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share consistent number of epidemiologic risk factors, the aim of this study was to investigate whether specific CP risk loci also contribute to PDAC susceptibility. We selected five common SNPs (rs11988997, rs379742, rs10273639 rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium...
September 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28912908/gastrin-releasing-peptide-and-glucose-metabolism-following-pancreatitis
#19
Sayali A Pendharkar, Marie Drury, Monika Walia, Murray Korc, Maxim S Petrov
BACKGROUND: Gastrin-releasing peptide (GRP) is a pluripotent peptide that has been implicated in both gastrointestinal inflammatory states and classical chronic metabolic diseases such as diabetes. Abnormal glucose metabolism (AGM) after pancreatitis, an exemplar inflammatory disease involving the gastrointestinal tract, is associated with persistent low-grade inflammation and altered secretion of pancreatic and gut hormones as well as cytokines. While GRP is involved in secretion of many of them, it is not known whether GRP has a role in AGM...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28912624/corrigendum-to-expression-and-clinical-significance-of-cancer-stem-cell-markers-cd24-cd44-and-cd133-in-pancreatic-ductal-adenocarcinoma-and-chronic-pancreatitis
#20
L Durko, W Wlodarski, O Stasikowska-Kanicka, M Wagrowska-Danilewicz, M Danilewicz, P Hogendorf, J Strzelczyk, E Malecka-Panas
[This corrects the article DOI: 10.1155/2017/3276806.].
2017: Disease Markers
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