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salivary microbiota

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https://www.readbyqxmd.com/read/29899737/dysbiosis-and-ecotypes-of-the-salivary-microbiome-associated-with-inflammatory-bowel-diseases-and-the-assistance-in-diagnosis-of-diseases-using-oral-bacterial-profiles
#1
Zhe Xun, Qian Zhang, Tao Xu, Ning Chen, Feng Chen
Inflammatory bowel diseases (IBDs) are chronic, idiopathic, relapsing disorders of unclear etiology affecting millions of people worldwide. Aberrant interactions between the human microbiota and immune system in genetically susceptible populations underlie IBD pathogenesis. Despite extensive studies examining the involvement of the gut microbiota in IBD using culture-independent techniques, information is lacking regarding other human microbiome components relevant to IBD. Since accumulated knowledge has underscored the role of the oral microbiota in various systemic diseases, we hypothesized that dissonant oral microbial structure, composition, and function, and different community ecotypes are associated with IBD; and we explored potentially available oral indicators for predicting diseases...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29881381/current-insights-in-microbiome-shifts-in-sjogren-s-syndrome-and-possible-therapeutic-interventions
#2
REVIEW
Christina Tsigalou, Elisavet Stavropoulou, Eugenia Bezirtzoglou
Sjogren's syndrome (SS) is an autoimmune disease, among the most common ones, that targets mainly the exocrine glands as well as extra-glandular epithelial tissues. Their lymphocytic infiltration leads to manifestations from other organs (e.g., kidneys, lungs, liver, or thyroid), apart from sicca symptoms (xerostomia and keratoconjunctivitis). SS is more prevalent in women than in men (9:1). Moreover, p.SS patients are in increased risk to develop lymphoma. Certain autoantibodies (e.g., antibodies against ribonucleoprotein autoantigens Ro-SSA and La-SSB) are ultimate hallmarks for the disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29878444/salivary-secretion-in-health-and-disease
#3
REVIEW
Anne Marie Lynge Pedersen, Christiane E Sørensen, Gordon B Proctor, Guy H Carpenter, Jörgen Ekström
Saliva is a complex fluid produced by three pairs of major salivary glands and by hundreds of minor salivary glands. It comprises a large variety of constituents and physicochemical properties, which are important for the maintenance of oral health. Saliva not only protects the teeth and the oropharyngeal mucosa, it also facilitates articulation of speech, and is imperative for mastication and swallowing. Furthermore, saliva plays an important role in maintaining a balanced microbiota. Thus, the multiple functions provided by saliva are essential for proper protection and functioning of the body as a whole and for the general health...
June 7, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29807159/nitrate-responsive-oral-microbiome-modulates-nitric-oxide-homeostasis-and-blood-pressure-in-humans
#4
Anni Vanhatalo, Jamie R Blackwell, Joanna L'Heureux, David W Williams, Ann Smith, Mark van der Giezen, Paul G Winyard, James Kelly, Andrew M Jones
Imbalances in the oral microbial community have been associated with reduced cardiovascular and metabolic health. A possible mechanism linking the oral microbiota to health is the nitrate (NO3 - )-nitrite (NO2 - )-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3 - to NO2 - . NO (generated from both NO2 - and L-arginine) regulates vascular endothelial function and therefore blood pressure (BP). By sequencing bacterial 16S rRNA genes we examined the relationships between the oral microbiome and physiological indices of NO bioavailability and possible changes in these variables following 10 days of NO3 - (12mmol/d) and placebo supplementation in young (18-22yrs) and old (70-79yrs) normotensive humans (n=18)...
May 25, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29796594/streptococcal-siglec-like-adhesins-recognize-different-subsets-of-human-plasma-glycoproteins-implications-for-infective-endocarditis
#5
Barbara A Bensing, Qiongyu Li, Dayoung Park, Carlito B Lebrilla, Paul M Sullam
Streptococcus gordonii and Streptococcus sanguinis are typically found among the normal oral microbiota, but can also cause infective endocarditis. These organisms express cell-surface serine-rich repeat adhesins containing "Siglec-like" binding regions (SLBRs) that mediate attachment to α2-3 linked sialic acids on human glycoproteins. Two known receptors for the Siglec-like adhesins are the salivary mucin MG2/MUC7 and platelet GPIbα, and the interaction of streptococci with these targets may contribute to oral colonization and endocarditis, respectively...
May 23, 2018: Glycobiology
https://www.readbyqxmd.com/read/29779275/-salivary-microbial-communities-associated-with-severe-early-childhood-caries
#6
Tong-Zheng Sun, Fei Teng, Song-Bo Jia, Yong-Ping Tang, Ming Jiang, Shi Huang, Xiao Yuan, Xiao-Lan Li, Fang Yang
OBJECTIVE: To compare the salivary microbial profiles of healthy subjects and those with severe early childhood caries (S-ECC) by using high-throughput sequencing. METHODS: Salivary samples were obtained from children with S-ECC (group C, n=24) and healthy children (group H, n=24). Total metagenomic DNA was extracted, and DNA amplicons of the V1-V3 hypervariable region of the 16S rRNA gene were generated and subjected to 454 sequencing. The characteristics of oral microbial communities from the two groups were compared based on microbial diversity and taxonomy assignment...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29753651/integrated-metatranscriptomics-and-metaproteomics-for-the-characterization-of-bacterial-microbiota-in-unfed-ixodes-ricinus
#7
Angélica Hernández-Jarguín, Sandra Díaz-Sánchez, Margarita Villar, José de la Fuente
An innovative metaomics approach integrating metatranscriptomics and metaproteomics was used to characterize bacterial communities in the microbiota of the Lyme borreliosis spirochete vector, Ixodes ricinus (Acari: Ixodidae). Whole internal tissues and salivary glands from unfed larvae and female ticks, respectively were used. Reused I. ricinus RNA-sequencing data for metranscriptomics analysis together with metaproteomics provided a better characterization of tick bacterial microbiota by increasing bacteria identification and support for identified bacteria with putative functional implications...
May 5, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29750437/green-tea-liquid-consumption-alters-the-human-intestinal-and-oral-microbiome
#8
Xiaojie Yuan, Yong Long, Zhaohua Ji, Jie Gao, Ting Fu, Min Yan, Lei Zhang, Haixia Su, Weilu Zhang, Xiaohui Wen, Zhongshu Pu, Hui Chen, Yufei Wang, Xu Gu, Binyuan Yan, Kanakaraju Kaliannan, Zhongjun Shao
SCOPE: GTPs exerts anti-CRC activity. The intestinal microbiota and intestinal colonization by bacteria of oral origin has been implicated in colorectal carcinogenesis. GT modulates the composition of mouse gut microbiota harmonious with anticancer activity. Therefore, we investigated the effect of GTL consumption on the gut and oral microbiome in healthy volunteers (n = 12). METHODS AND RESULTS: 16S sequencing and PICRUSt analysis of both fecal and saliva samples (collected before intervention, after 2 weeks of GTL (400 ml/day) and after a washout period of one week) in healthy volunteers showed changes in microbial diversity and core microbiota and difference in clear classification (PLS-DA)...
May 11, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29713004/obese-subjects-with-specific-gustatory-papillae-microbiota-and-salivary-cues-display-an-impairment-to-sense-lipids
#9
Philippe Besnard, Jeffrey E Christensen, Hélène Brignot, Arnaud Bernard, Patricia Passilly-Degrace, Sophie Nicklaus, Jean-Paul Pais de Barros, Xavier Collet, Benjamin Lelouvier, Florence Servant, Vincent Blasco, Bruno Verges, Laurent Lagrost, Gilles Feron, Rémy Burcelin
Some obese subjects overeat lipid-rich foods. The origin of this eating behavior is unknown. We have here tested the hypothesis that these subjects could be characterized by an impaired fatty taste sensitivity linked to a change in the gustatory papillae microbial and salivary environment. The composition of microbiota and saliva surrounding the circumvallate papillae was analyzed in combination with the orosensory lipid detection threshold in normal weight (NW) and obese (O) adults. Microbial architecture was similar to what was known in feces, but with an increased frequency of Proteobacteria...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29702004/human-trna-derived-small-rnas-modulate-host-oral-microbial-interactions
#10
X He, F Li, B Bor, K Koyano, L Cen, X Xiao, W Shi, D T W Wong
Coevolution of the human host and its associated microbiota has led to sophisticated interactions to maintain a delicate homeostasis. Emerging evidence suggests that in addition to small molecules, peptides, and proteins, small regulatory noncoding RNAs (sRNAs) might play an important role in cross-domain interactions. In this study, we revealed the presence of diverse host transfer RNA-derived small RNAs (tsRNAs) among human salivary sRNAs. We selected 2 tsRNAs (tsRNA-000794 and tsRNA-020498) for further study based on their high sequence similarity to specific tRNAs from a group of Gram-negative oral bacteria, including Fusobacterium nucleatum, a key oral commensal and opportunistic pathogen...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29700993/discovery-of-antimicrobial-lipodepsipeptides-produced-by-a-serratia-sp-within-mosquito-microbiomes
#11
Jack Ganley, Gavin Carr, Thomas Ioerger, James Sacchettini, Jon Clardy, Emily Derbyshire
The Anopheles mosquito that harbors the Plasmodium parasite contains a microbiota that can influence both the vector and parasite. In recent years, insect-associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a Serratia sp. within the midgut and salivary glands of A. stephensi mosquitoes. The lipodepsipeptides, stephensiolides A-K, have antibiotic activity and facilitate bacterial surface motility...
April 26, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29670544/dynamic-alterations-in-salivary-microbiota-related-to-dental-caries-and-age-in-preschool-children-with-deciduous-dentition-a-2-year-follow-up-study
#12
Lei Xu, Xi Chen, Yuan Wang, Wen Jiang, Sa Wang, Zongxin Ling, Hui Chen
Dynamic alterations in oral microbiota are closely related to the development of dental caries;however, changes in salivary microbiota during this process have not been extensively studied. In addition, increasing evidence suggests that oral microbiome profiles differ according to dentition stages, but it is unclear whether they change with age during the same dentition, such as deciduous dentition. These two aspects were investigated in a 2-year follow-up study, and caries-free preschool children with complete deciduous dentition were enrolled...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29662960/impact-of-oral-hygiene-discontinuation-on-supragingival-and-salivary-microbiomes
#13
D Belstrøm, M L Sembler-Møller, M A Grande, N Kirkby, S L Cotton, B J Paster, S Twetman, P Holmstrup
The purpose of the present study was to characterize and compare supragingival and salivary microbiotas during a 10-d period of oral hygiene discontinuation. We tested the hypothesis that the composition of the salivary microbiota will reflect local microbial changes associated with accumulated biofilm formation and maturation. Pooled supragingival plaque ( n = 145) and stimulated saliva ( n = 145) samples were collected and plaque and gingival indices were recorded from 29 orally healthy individuals at baseline, during oral hygiene discontinuation (days 4, 7, and 10), and 14 d after resumption of oral hygiene...
January 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29643500/impact-of-a-vegan-diet-on-the-human-salivary-microbiota
#14
Tue H Hansen, Timo Kern, Emilie G Bak, Alireza Kashani, Kristine H Allin, Trine Nielsen, Torben Hansen, Oluf Pedersen
Little is known about the effect of long-term diet patterns on the composition and functional potential of the human salivary microbiota. In the present study, we sought to contribute to the ongoing elucidation of dietary effects on the oral microbial community by examining the diversity, composition and functional potential of the salivary microbiota in 160 healthy vegans and omnivores using 16S rRNA gene amplicon sequencing. We further sought to identify bacterial taxa in saliva associated with host inflammatory markers...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615776/dysbiosis-of-the-salivary-microbiota-in-pediatric-onset-primary-sclerosing-cholangitis-and-its-potential-as-a-biomarker
#15
Kentaro Iwasawa, Wataru Suda, Tomoyuki Tsunoda, Manari Oikawa-Kawamoto, Shuichiro Umetsu, Lena Takayasu, Ayano Inui, Tomoo Fujisawa, Hidetoshi Morita, Tsuyoshi Sogo, Masahira Hattori
Primary sclerosing cholangitis (PSC) is a liver disease known for its frequent concurrence with inflammatory bowel disease. Dysbiosis of the gut microbiota in PSC was reported in several studies, but the microbiological features of the salivary microbiota in PSC have not been established. Here we compared the salivary microbial communities of 24 pediatric-onset PSC patients, 16 age-matched ulcerative colitis (UC) patients, and 24 healthy controls (HCs) by analyzing the bacterial 16S rRNA gene sequence data...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614112/a-fine-tuned-vector-parasite-dialogue-in-tsetse-s-cardia-determines-peritrophic-matrix-integrity-and-trypanosome-transmission-success
#16
Aurélien Vigneron, Emre Aksoy, Brian L Weiss, Xiaoli Bing, Xin Zhao, Erick O Awuoche, Michelle B O'Neill, Yineng Wu, Geoffrey M Attardo, Serap Aksoy
Arthropod vectors have multiple physical and immunological barriers that impede the development and transmission of parasites to new vertebrate hosts. These barriers include the peritrophic matrix (PM), a chitinous barrier that separates the blood bolus from the midgut epithelia and modulates vector-pathogens interactions. In tsetse flies, a sleeve-like PM is continuously produced by the cardia organ located at the fore- and midgut junction. African trypanosomes, Trypanosoma brucei, must bypass the PM twice; first to colonize the midgut and secondly to reach the salivary glands (SG), to complete their transmission cycle in tsetse...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29602225/oral-microbiota-maturation-during-the-first-7-years-of-life-in-relation-to-allergy-development
#17
Majda Dzidic, Thomas Abrahamsson, Alejandro Artacho, Maria Carmen Collado, Alex Mira, Maria C Jenmalm
BACKGROUND: Allergic diseases have become a major public health problem in affluent societies. Microbial colonization early in life seems to be critical for instructing regulation on immune system maturation and allergy development in children. Even though the oral cavity is the first site of encounter between a majority of foreign antigens and the immune system, the influence of oral bacteria on allergy development has not yet been reported. OBJECTIVE: We sought to determine the bacterial composition in longitudinally collected saliva samples during childhood in relation to allergy development...
March 30, 2018: Allergy
https://www.readbyqxmd.com/read/29559963/the-impact-of-maltitol-sweetened-chewing-gum-on-the-dental-plaque-biofilm-microbiota-composition
#18
Bart J F Keijser, Tim J van den Broek, Dagmar E Slot, Lodewic van Twillert, Jolanda Kool, Clémentine Thabuis, Michel Ossendrijver, Fridus A van der Weijden, Roy C Montijn
Background: The oral cavity harbors a complex microbial ecosystem, intimately related to oral health and disease. The use of polyol-sweetened gum is believed to benefit oral health through stimulation of salivary flow and impacting oral pathogenic bacteria. Maltitol is often used as sweetener in food products. This study aimed to establish the in vivo effects of frequent consumption of maltitol-sweetened chewing gum on the dental plaque microbiota in healthy volunteers and to establish the cellular and molecular effects by in vitro cultivation and transcriptional analysis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29533791/supragingival-and-subgingival-microbiota-from-patients-with-poor-oral-hygiene-submitted-to-radiotherapy-for-head-and-neck-cancer-treatment
#19
Elerson Gaetti-Jardim, Ellen Cristina Gaetti Jardim, Christiane Marie Schweitzer, Júlio Cesar Leite da Silva, Murilo Moura Oliveira, Danilo Chizzolini Masocatto, Cauê Monteiro Dos Santos
OBJECTIVE: This case-control study aimed to evaluate the effects of conventional radiotherapy (RT) on the prevalence and populations of oral microorganisms in head and neck cancer patients who did not receive adequate preventive dental care. It was hypothesized that side effects of radiotherapy could be associated with radiation dose, microbiological aspects, and socioeconomic conditions of the patients. DESIGN: Twenty-eight dentate patients with head and neck cancer submitted to RT were included in the study...
June 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29520798/influence-of-periodontal-treatment-on-subgingival-and-salivary-microbiotas
#20
Daniel Belstrøm, Maria Anastasia Grande, Maria Lynn Sembler-Møller, Nikolai Kirkby, Sean L Cotton, Bruce J Paster, Palle Holmstrup
BACKGROUND: The purpose of this study was to characterize and compare subgingival and salivary microbiotas before and after periodontal treatment to learn if any changes of the subgingival microbiota were reflected in saliva. We tested the hypothesis that salivary levels of specific periopathogens correlate with corresponding subgingival levels before and after periodontal treatment. METHODS: Twenty-five patients with generalized chronic periodontitis completed the study...
February 19, 2018: Journal of Periodontology
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