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Musculoskeletal Oncology

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https://www.readbyqxmd.com/read/28096718/diffuse-large-b-cell-lymphoma-in-the-era-of-precision-oncology-how-imaging-is-helpful
#1
REVIEW
Hina J Shah, Abhishek R Keraliya, Jyothi P Jagannathan, Sree Harsha Tirumani, Vikram R Lele, Pamela J DiPiro
Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's lymphoma. As treatments continues to evolve, so do imaging strategies, and positron emission tomography (PET) has emerged as the most important imaging tool to guide oncologists in the diagnosis, staging, response assessment, relapse/recurrence detection,and therapeutic decision making of DLBCL. Other imaging modalities including magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, and conventional radiography are also used in the evaluation of lymphoma...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28090451/potential-of-pet-mri-for-imaging-of-non-oncologic-musculoskeletal-disease
#2
REVIEW
Feliks Kogan, Audrey P Fan, Garry E Gold
Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important. New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28069064/pasteurized-autograft-reconstruction-after-resection-of-periacetabular-malignant-bone-tumours
#3
Xiaoning Guo, Xiaoyang Li, Tang Liu, Cijun Shuai, Qing Zhang
BACKGROUND: The treatment of periacetabular malignant bone tumours is challenging. Many methods of reconstruction after internal hemipelvectomy have been reported and each method has its own limitations. The aim of this study was to evaluate the oncological and functional outcomes of pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours. METHODS: Ten patients (six male, four female) with periacetabular malignant tumours, who underwent resection and reconstruction with pasteurized autograft, were retrospectively reviewed...
January 9, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27995558/is-there-benefit-to-free-over-pedicled-vascularized-grafts-in-augmenting-tibial-intercalary-allograft-constructs
#4
Marco Manfrini, Srimanth Bindiganavile, Ferhat Say, Marco Colangeli, Laura Campanacci, Massimiliano Depaolis, Massimo Ceruso, Davide Donati
BACKGROUND: Intercalary reconstruction of tibial sarcomas with vascularized fibula autografts and massive bone allografts is reliable with predictable long-term results. However, inadequate data exist comparing free and pedicled vascularized fibula autografts in combination with a massive bone allograft in patients undergoing intercalary tibia reconstructions. QUESTIONS/PURPOSES: Among patients undergoing large-segment intercalary allografting, we sought to compare supplemental free vascularized fibular autografts with supplemental pedicled vascularized fibular autografts, in terms of (1) oncologic results, (2) complications associated with surgery, (3) Musculoskeletal Tumor Society (MSTS) scores, and (4) surgical time...
December 19, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27978582/a-comparison-of-vascularized-free-fibular-flaps-and-nonvascularized-fibular-grafts-for-reconstruction-of-long-bone-defects-after-tumor-resection
#5
Emmanuel Pantaleon Estrella, Edward H M Wang
Background The use of the fibula autograft has been a reliable method in the reconstruction of long bone defects after tumor resection. The objective of this study was to report the outcomes fibular grafting in terms of graft union, functional score, complications, and oncologic outcome. Methods A retrospective review of patients with fibular grafting after tumor resection was done from January 1, 1993 to December 31, 2013. The primary outcome was graft union and the revised musculoskeletal tumor society scoring system (MSTS score)...
December 15, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27956077/modular-cementless-prosthetic-reconstruction-after-resection-of-lower-extremity-malignant-tumor
#6
Senol Bekmez, Mehmet Ayvaz, Altug Yucekul, Mazhar Tokgozoglu
INTRODUCTION: The aim of the study is to report the preliminary clinical and functional outcomes of a modular cementless tumor resection prosthesis system (Megasystem-C(®), Waldemar Link GmbH&Co. KG, Hamburg, Germany) in patients undergoing limb salvage surgery with wide resection in a lower extremity primary or metastatic malignant bone tumor. MATERIAL AND METHODS: Fifty-two consecutive patients (33 male and 19 female; mean age 37.1 years (range, 16 to 79) with primary or metastatic lower extremity malignant bone tumor who underwent wide resection and reconstruction with cementless Megasystem-C(®) system were included in the study...
December 9, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27955655/short-to-long-term-follow-up-of-total-femoral-replacement-in-non-oncologic-patients
#7
Andreas Toepfer, Norbert Harrasser, Isabel Petzschner, Florian Pohlig, Ulrich Lenze, Ludger Gerdesmeyer, Dominik Pförringer, Marcel Toepfer, Marc Beirer, Moritz Crönlein, Ruediger von Eisenhart-Rothe, Heinz Mühlhofer
BACKGROUND: Compromised bone stock and heavily impaired structural integrity after multiple endoprosthetic revision surgeries can lead to a comparable condition as encountered in musculoskeletal tumor surgery. Total femoral replacement (TFR) can restore femoral integrity and allow patients to resume ambulation. Even though several authors reported their results of TFR, so far many questions are still on debate: Which patients are at risk to experience low functional outcome? Do complications and clinical outcome after TFR depend on the indication for the surgery (e...
December 12, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27889461/intralesional-curettage-of-central-low-grade-chondrosarcoma-a-midterm-follow-up-study
#8
Yi-Chou Chen, Po-Kuei Wu, Cheng-Fong Chen, Wei-Ming Chen
BACKGROUND: The aim of this study was to review the experience of surgical treatment of low-grade chondrosarcoma and to assess the long-term oncological and functional outcomes between intralesional curettage and wide excision. METHODS: We included 11 patients with central low-grade chondrosarcoma lesions treated with intralesional curettage or wide excision from 1998 to 2013. Seven patients were treated with intralesional curettage and local adjuvant treatment (Group A), and four patients were treated with wide excision and reconstructive surgery (Group B)...
November 23, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27791830/contralateral-osteotomy-of-the-pedicle-and-posterolateral-elements-for-en-bloc-resection-a-technique-for-oncological-resection-of-posterolateral-spinal-tumors
#9
Viren S Vasudeva, Alexander E Ropper, Samuel Rodriguez, Kyle C Wu, John H Chi
En bloc resection of tumors involving the spinal column is technically challenging and is associated with high morbidity to the patient due to the proximity of critical neurological and vascular structures and the destabilizing nature of this surgery. Nevertheless, evidence has shown improved progression-free survival with en bloc resection for certain low-grade malignant and aggressive benign musculoskeletal tumors. To avoid the morbidity of en bloc spondylectomy in patients with tumors localized to the lateral and posterolateral spinal column, the authors have found that the goals of surgery can be accomplished through a contralateral osteotomy of the pedicle and posterolateral elements for en bloc resection (COPPER)...
October 28, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27766456/erratum-to-atypical-and-malignant-granular-cell-tumors-in-japan-a-japanese-musculoskeletal-oncology-group-jmog-study
#10
Jungo Imanishi, Yasuo Yazawa, Tsuyoshi Saito, Michio Shimizu, Hiroyuki Kawashima, Keisuke Ae, Akihiko Matsumine, Tomoaki Torigoe, Hideshi Sugiura, Susumu Joyama
No abstract text is available yet for this article.
December 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27752811/ergonomics-in-the-operating-room
#11
Shiromani Janki, Evalyn E A P Mulder, Jan N M IJzermans, T C Khe Tran
BACKGROUND: Since the introduction of minimally invasive surgery, surgeons appear to be experiencing more occupational musculoskeletal injuries. The aim of this study is to investigate the current frequency and effects of occupational musculoskeletal injuries on work absence. METHODS: An online questionnaire was conducted among all surgeons affiliated to the Dutch Society for Endoscopic Surgery, Gastrointestinal Surgery, and Surgical Oncology. In addition, this survey was conducted among surgeons, gynaecologists, and urologists of one cluster of training hospitals in the Netherlands...
October 17, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27737652/ct-guided-cryoablation-for-locally-recurrent-or-metastatic-bone-and-soft-tissue-tumor-initial-experience
#12
Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka
BACKGROUND: Historically, local control of recurrent sarcomas has been limited to radiotherapy when surgical re-resection is not feasible. For metastatic carcinomas to the bone or soft tissue, radiotherapy and some interventional radiology treatment along with other systemic therapies have been widely advocated due to the possibility of disseminated disease. These techniques are effective in alleviating pain and achieving local control for some tumor types, but it has not been effective for prolonged local control of most tumors...
October 13, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27693681/do-no-harm-except-to-ourselves-a-survey-of-symptoms-and-injuries-in-oncologic-surgeons-and-pilot-study-of-an-intraoperative-ergonomic-intervention
#13
Rachel K Voss, Yi-Ju Chiang, Kate D Cromwell, Diana L Urbauer, Jeffrey E Lee, Janice N Cormier, Chee-Chee H Stucky
BACKGROUND: Occupational symptoms and injuries incurred over a surgical career are under- reported, yet they have an impact on daily surgical practice. We assessed the frequency, consequences, and risk factors for occupational injury in oncologic surgeons and evaluated the feasibility of intraoperative foot mat use to mitigate occupational symptoms. STUDY DESIGN: Oncologic surgeons completed a survey of demographic information and occupational symptoms and injuries...
January 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27642605/silver-coated-hip-megaprosthesis-in-oncological-limb-savage-surgery
#14
F Donati, G Di Giacomo, S D'Adamio, A Ziranu, S Careri, Ma Rosa, G Maccauro
Silver coating has demonstrated good antimicrobial activity and low toxicity. Silver-coated megaprostheses have been introduced in oncological musculoskeletal surgery considering the high rate of infection. We conducted a retrospective analysis on 68 cases of primary or metastatic bone tumors, affecting the proximal femur, treated between 2005 and 2016 with wide margins resection and tumor implants reconstruction. All patients were treated by the same surgeon, with antibiotic prophylaxis according to a standard protocol...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27566370/tissue-engineering-and-regenerative-medicine-in-musculoskeletal-oncology
#15
Boris Michael Holzapfel, Ferdinand Wagner, Laure Christine Martine, Stephan Reppenhagen, Maximilian Rudert, Michael Schuetz, Jim Denham, Jan-Thorsten Schantz, Dietmar Werner Hutmacher
Currently used surgical techniques to reconstruct tissue defects after resection of musculoskeletal tumours are associated with high complication rates. This drives a strong demand for innovative therapeutic concepts that are able to improve the clinical outcomes of patients suffering from bone and soft tissue tumours. Tissue engineering and regenerative medicine (TE&RM) provides a technology platform based on biochemical, molecular, cellular and biomaterials modules to selectively direct tissue healing processes for improved defect regeneration...
2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/27563249/antihormonal-treatment-associated-musculoskeletal-pain-in-women-with-breast-cancer-in-the-adjuvant-setting
#16
Selcuk Seber, Dilek Solmaz, Tarkan Yetisyigit
PURPOSE: Antihormonal treatment is an effective therapy in the adjuvant setting. However, musculoskeletal pain is a common adverse effect encountered in patients receiving this treatment. We aimed to evaluate the risk factors for the development of antihormonal treatment-associated musculoskeletal pain (AHAMP) and its impact on the health-related quality of life (HRQOL). PATIENTS AND METHODS: A cross-sectional survey of 78 consecutive breast cancer patients receiving adjuvant antihormonal treatment for early-stage breast cancer in an academic medical oncology clinic was conducted...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27559251/palliative-care-in-musculoskeletal-oncology
#17
REVIEW
Ashish Gulia, Suman Byregowda, Pankaj Kumar Panda
Patients in advanced stages of illness trajectories with local and widespread musculoskeletal incurable malignancies, either treatment naive or having recurrence are referred to the palliative care clinic to relieve various disease-related symptoms and to improve the quality of life. Palliative care is a specialized medicine that offers treatment to the disease-specific symptoms, places emphasis on the psychosocial and spiritual aspects of life and help the patients and their family to cope with advance stage cancer in a stronger and reasonable way...
July 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27546723/modular-megaprosthesis-reconstruction-for-oncological-and-non-oncological-resection-of-the-elbow-joint
#18
Rodolfo Capanna, Francesco Muratori, Francesco R Campo, Antonio D'Arienzo, Filippo Frenos, Giovanni Beltrami, Guido Scoccianti, Pierluigi Cuomo, Andrea Piccioli, Daniel A Müller
BACKGROUND: Reconstruction of large bone defects around the elbow joint is surgically demanding due to sparse soft tissue coverage, complex biomechanics and the close proximity to neurovascular structures. Modular megaprostheses are established reconstruction tools for the elbow, but only small case series have been reported in the literature. METHODS: Thirty-six patients who underwent reconstruction of the elbow joint with a modular megaprosthesis were reviewed retrospectively...
October 2016: Injury
https://www.readbyqxmd.com/read/27536136/oncological-outcome-after-lung-metastasis-in-patients-presenting-with-localized-chondrosarcoma-at-extremities-tokai-musculoskeletal-oncology-consortium-study
#19
Tomoki Nakamura, Akihiko Matsumine, Satoshi Yamada, Satoshi Tsukushi, Katsuhisa Kawanami, Takatoshi Ohno, Hirohisa Katagiri, Hideshi Sugiura, Kenji Yamada, Yoshihisa Yamada, Akihiro Sudo, Yoshihiro Nishida
The oncological outcome after lung metastasis in patients with chondrosarcoma of the extremities has not been reported. Between June 2000 and June 2013, 179 patients with chondrosarcoma in the extremities were treated at eleven hospitals. Twenty consecutive patients (11.2%) developed lung metastases after initial treatment of primary chondrosarcoma in the extremities. We investigated the oncological outcome of 20 chondrosarcoma patients with lung metastasis. There were 14 males and six females with a mean age of 49 years...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27511202/are-recently-trained-tumor-fellows-performing-less-tumor-surgery-an-analysis-of-10-years-of-the-abos-part-ii-database
#20
Kyle R Duchman, Benjamin J Miller
BACKGROUND: The majority of orthopaedic trainees pursue additional subspecialty training at the conclusion of residency. Although national trends indicate that fellowship-trained surgeons are more frequently performing cases in their defined subspecialties, this may not be the case for recently trained tumor fellows. Prior work has established that low tumor case volume is a significant stressor for recently trained tumor fellows. Given the relative rarity of musculoskeletal tumors, it is important for prospective trainees to have clear expectations for the proportion of specialty-specific procedures early during their careers...
January 2017: Clinical Orthopaedics and related Research
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