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Musculoskeletal Oncology

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https://www.readbyqxmd.com/read/29762195/functional-outcomes-and-complications-after-oncologic-reconstruction-of-the-proximal-humerus
#1
Sjoerd Nota, Teun Teunis, Joost Kortlever, Marco Ferrone, John Ready, Mark Gebhardt, Kevin Raskin, Francis Hornicek, Joseph Schwab, Santiago Lozano Calderon
BACKGROUND: No consensus exists on the best method of articular reconstruction in patients who require proximal humerus resection for the management of primary bone sarcomas, soft-tissue sarcomas extending into the bone, benign and locally aggressive primary bone tumors, and metastatic disease. METHODS: We identified patients from two institutions who underwent wide resection of the proximal humerus along with oncologic reconstruction using osteoarticular allografts (OAs), endoprostheses, or allograft-prosthesis composites...
June 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29715130/osteoscopic-surgery-of-giant-cell-tumor-of-bone-for-preservation-of-proximal-fibula
#2
Hiroyuki Futani, Shunsuke Kumanishi, G O Minakawa, Shinichi Yoshiya
BACKGROUND: Osteoscopy is a minimally-invasive endoscopic technique for inspecting lesions inside bone marrow cavities. We describe the feasibility of osteoscopic surgery of giant cell tumor of bone (GCTB) in order to preserve the proximal fibula, and thereby achieve immediate recovery and avoid complications. PATIENTS AND METHODS: Five patients with GCTB in the proximal fibula were treated using osteoscopic curettage with adjuvants (argon plasma coagulation and cementation)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29688908/surgical-outcomes-after-limb-sparing-resection-and-reconstruction-for-pelvic-sarcoma-a-systematic-review
#3
Robert J Wilson, Thomas H Freeman, Jennifer L Halpern, Herbert S Schwartz, Ginger E Holt
BACKGROUND: Limb-sparing resection and reconstruction for pelvic sarcomas in multiple small studies have been fraught with complications, reoperations, and impaired patient function. However, the non-oncologic complication and reoperation rates and functional outcomes for patients have never been rigorously compiled, to our knowledge. A systematic review was undertaken to more accurately determine the non-oncologic complication and reoperation rates and functional outcomes for patients after pelvic sarcoma resection and reconstruction...
April 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29688859/patient-derived-xenograft-models-in-musculoskeletal-malignancies
#4
REVIEW
Wan Lu, Tu Chao, Chen Ruiqi, Su Juan, Li Zhihong
Successful oncological drug development for bone and soft tissue sarcoma is grossly stagnating. A major obstacle in this process is the lack of appropriate animal models recapitulating the complexity and heterogeneity of musculoskeletal malignancies, resulting in poor efficiency in translating the findings of basic research to clinical applications. In recent years, patient-derived xenograft (PDX) models generated by directly engrafting patient-derived tumor fragments into immunocompromised mice have recaptured the attention of many researchers due to their properties of retaining the principle histopathology, biological behaviors, and molecular and genetic characteristics of the original tumor, showing promising future in both basic and clinical studies of bone and soft tissue sarcoma...
April 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29602957/nanotechnology-the-scope-and-potential-applications-in-orthopedic-surgery
#5
EDITORIAL
Ashok Gavaskar, D Rojas, F Videla
Nanotechnology involves manipulation of matter measuring 1-100 nm in at least one of its dimensions at the molecular level. Engineering and manipulation of matter at the molecular level has several advantages in the field of medicine (nanomedicine) since most of the biological molecules exist and function at a nanoscale. Though promising, questions still remain on how much of this will ultimately translate into achieving better patient care. Concerns of cost-effectiveness and nanotechnology safety still remain unclear...
March 30, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29529637/early-improvement-in-pain-and-functional-outcome-but-not-quality-of-life-after-surgery-for-metastatic-long-bone-disease
#6
Anas Nooh, Krista Goulding, Marc H Isler, Sophie Mottard, Annie Arteau, Norbert Dion, Robert Turcotte
BACKGROUND: Bone metastases represent the most frequent cause of cancer-related pain, affecting health-related quality of life and creating a substantial burden on the healthcare system. Although most bony metastatic lesions can be managed nonoperatively, surgical management can help patients reduce severe pain, avoid impending fracture, and stabilize pathologic fractures. Studies have demonstrated functional improvement postoperatively as early as 6 weeks, but little data exist on the temporal progress of these improvements or on the changes in quality of life over time as a result of surgical intervention...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29529633/is-navigation-guided-en-bloc-resection-advantageous-compared-with-intralesional-curettage-for-locally-aggressive-bone-tumors
#7
Germán L Farfalli, Jose I Albergo, Nicolas S Piuzzi, Miguel A Ayerza, D Luis Muscolo, Lucas E Ritacco, Luis A Aponte-Tinao
BACKGROUND: The treatment of locally aggressive bone tumors is a balance between achieving local tumor control and surgical morbidity. Wide resection decreases the likelihood of local recurrence, although wide resection may result in more complications than would happen after curettage. Navigation-assisted surgery may allow more precise resection, perhaps making it possible to expand the procedure's indications and decrease the likelihood of recurrence; however, to our knowledge, comparative studies have not been performed...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29473959/reconstruction-using-a-constrained-type-hip-tumor-prosthesis-after-resection-of-malignant-periacetabular-tumors-a-study-by-the-japanese-musculoskeletal-oncology-group-jmog
#8
Koichi Ogura, Michiro Susa, Hideo Morioka, Akihiko Matsumine, Takeshi Ishii, Kenichiro Hamada, Takafumi Ueda, Akira Kawai
BACKGROUND: We conducted a nationwide survey of prosthetic reconstruction using a constrained-type hip tumor prosthesis (C-THA) following resection of periacetabular tumors. METHODS: Eighty patients with periacetabular tumors underwent wide resection and prosthetic reconstruction using C-THA at JMOG-affiliated institutions (39 males and 41 females; mean age, 46.7 years; mean follow-up period, 65 months). Primary bone or soft tissue sarcoma accounted for 75% of the cases...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473369/-clinical-data-analysis-of-2491-acupuncture-inpatient-consultations-a-report-from-qilu-hospital-of-shandong-university
#9
Xiaobin Ge, Lei Zhang, Gonglei Yue, Xuewei Xiao, Zhenjie Yang, Bin Tang, Shumei Wu, Yan Li, Guangzhong Du
OBJECTIVE: To summarize the 2491 acupuncture inpatient consultations in Qilu Hospital of Shandong University during 2014, and analyze the application of acupuncture in comprehensive hospital, hoping to provide direction and methods for clinical practice and scientific research of acupuncture. METHODS: The consultation record and hospitalization information during 2014 in Department of Acupuncture-Moxibustion and Tuina, Qilu Hospital of Shandong University, were collected and summarized through Inpatient Information Management System...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29460155/pelvic-reconstructions-following-peri-acetabular-bone-tumour-resections-using-a-cementless-ice-cream-cone-prosthesis-with-dual-mobility-cup
#10
Samir-Pierre Issa, David Biau, Antoine Babinet, Valérie Dumaine, Malo Le Hanneur, Philippe Anract
PURPOSE: Despite numerous reconstructive techniques and prosthetic devices, pelvic reconstructions following peri-acetabular malignant tumours resections are highly challenging. In the present study, we describe our experience with the Integra® (Lépine, Genay, France) ice-cream cone prosthesis in such indications. The objective was to assess the mid-term outcomes of this device. METHODS: Twenty-four patients' chart with peri-acetabular malignant tumours, who underwent types II or II + III peri-acetabular resections according to Enneking and Dunham with subsequent reconstruction using the Integra® prosthesis between February 2009 and February 2015, were reviewed...
January 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29427125/survival-complications-and-functional-outcomes-of-cemented-megaprostheses-for-high-grade-osteosarcoma-around-the-knee
#11
Chunlin Zhang, Jianping Hu, Kunpeng Zhu, Tao Cai, Xiaolong Ma
PURPOSE: We initiated a retrospective study on the long-term survival of cemented endoprostheses for bone tumours around the knee to answer the following questions: (1) What was the survival of these patients? (2) What was the overall survival of cemented prostheses around the knee? (3) What types of failures were observed in these reconstructions? (4) Did the survival and complications vary according to the site of the implant? (5) What was the functional result after cemented prosthesis replacement around the knee? METHODS: From January 2006 to December 2013, 108 consecutive patients with an average age of 25 years, who had mature bone development as evidenced by imaging examinations, underwent 108 cemented endoprosthetic knee replacements for osteosarcoma resection...
April 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29416172/gait-analysis-in-patients-with-wide-resection-and-endoprosthesis-replacement-around-the-knee
#12
Vivek Ajit Singh, Chan Wei Heng, Nor Faissal Yasin
Background: Limb salvage surgery with endoprosthesis for bone tumor around the knee is reported to have good functional and oncological outcomes. However, the functional assessment using musculoskeletal tumor society (MSTS) and Toronto extremity scoring system remains subjective. We performed gait analysis as an objective assessment of their functional outcome. Materials and Methods: Gait analysis was performed in 20 patients with endoprosthesis replacement around the knee...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29416166/navigation-in-musculoskeletal-oncology-an-overview
#13
Guy Vernon Morris, Jonathan D Stevenson, Scott Evans, Michael C Parry, Lee Jeys
Navigation in surgery has increasingly become more commonplace. The use of this technological advancement has enabled ever more complex and detailed surgery to be performed to the benefit of surgeons and patients alike. This is particularly so when applying the use of navigation within the field of orthopedic oncology. The developments in computer processing power coupled with the improvements in scanning technologies have permitted the incorporation of navigational procedures into day-to-day practice. A comprehensive search of PubMed using the search terms "navigation", "orthopaedic" and "oncology" yielded 97 results...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29416162/musculoskeletal-oncology-finding-its-place-in-the-sun
#14
EDITORIAL
Ajay Puri
No abstract text is available yet for this article.
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29406473/characteristics-of-pediatric-patient-transferred-from-hospital-based-general-emergency-departments-to-acute-care-facilities-an-analysis-of-the-healthcare-cost-and-utilization-project-nationwide-emergency-department-sample
#15
Isabel Araujo Barata, Meredith Akerman, Zayan Mahmooth, Kathryn Bradburn, John DʼAngelo
STUDY OBJECTIVE: The objective of this study was to analyze the characteristics of pediatric patients transferred from a hospital-based general emergency department (ED) to an acute care facility. METHODS: Study data were abstracted from the 2010 Healthcare Cost and Utilization Project Nationwide Emergency Department Sample database. A multivariate logistic regression was constructed for pediatric patients (<18 years old) who require a transfer to an acute care facility from a general ED...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29399352/surgical-management-of-metastatic-lesions-of-the-proximal-femur-with-pathological-fractures-using-intramedullary-nailing-or-endoprosthetic-replacement
#16
Zeping Yu, Yan Xiong, Rui Shi, Li Min, Wenli Zhang, Hongyuan Liu, Xiang Fang, Chongqi Tu, Hong Duan
Endoprosthetic replacement (EPR) and intramedullary nailing (IMN) are the two most commonly applied surgical methods used to treat proximal metastatic lesions; however, indication of the above procedures remains controversial. The aim of the present study was to evaluate the clinical, functional and oncological outcomes of patients who underwent EPR compared to IMN for the treatment of proximal femur metastases to investigate the surgical indication for patients. The records of patients (n=88) with pathological fractures secondary to metastatic tumors of the proximal femur admitted between January 2005 and December 2014 to West China Hospital, Sichuan University (Chengdu, China) were retrospectively studied...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29397412/resection-arthrodesis-using-distraction-osteogenesis-then-plating-as-a-hybrid-surgical-technique-for-the-management-of-bone-sarcomas-of-the-distal-tibia
#17
Teng-Fei Lou, Hua Li, Yi-Min Chai, Chun-Yang Wang, Sheng-He Liu, Musha Hamushan, Fan Wu, Wei-Jie Cai, Pei Han
PURPOSE: We report the oncological and functional results of limb salvage for bone sarcomas involving the distal tibia using hybrid surgical technique of resection arthrodesis by bone transport then plating. METHODS: Five patients (mean age 18.6 years) with primary distal tibial sarcomas (two Ewing's sarcomas and three osteosarcomas) were treated by this method. The average duration of follow-up is 53 months. All patients accepted distraction osteogenesis with a standard technique using external fixator after wide (four cases) or marginal (one case) resection in the first operation...
March 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29388687/interventions-for-weight-reduction-in-obesity-to-improve-survival-in-women-with-endometrial-cancer
#18
REVIEW
Sarah Kitson, Neil Ryan, Michelle L MacKintosh, Richard Edmondson, James Mn Duffy, Emma J Crosbie
BACKGROUND: Diagnoses of endometrial cancer are increasing secondary to the rising prevalence of obesity. Obesity plays an important role in promoting the development of endometrial cancer, by inducing a state of unopposed oestrogen excess, insulin resistance and inflammation. It also affects treatment, increasing the risk of surgical complications and the complexity of radiotherapy planning, and may additionally impact on subsequent survival. Weight-loss interventions have been associated with improvements in breast and colorectal cancer-specific survival as well as a reduction in the risk of cardiovascular disease, a frequent cause of death in endometrial cancer survivors...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29388071/yoga-for-the-management-of-cancer-treatment-related-toxicities
#19
REVIEW
Po-Ju Lin, Luke J Peppone, Michelle C Janelsins, Supriya G Mohile, Charles S Kamen, Ian R Kleckner, Chunkit Fung, Matthew Asare, Calvin L Cole, Eva Culakova, Karen M Mustian
PURPOSE OF REVIEW: To (1) explain what yoga is, (2) summarize published literature on the efficacy of yoga for managing cancer treatment-related toxicities, (3) provide clinical recommendations on the use of yoga for oncology professionals, and (4) suggest promising areas for future research. RECENT FINDINGS: Based on a total of 24 phase II and one phase III clinical trials, low-intensity forms of yoga, specifically gentle hatha and restorative, are feasible, safe, and effective for treating sleep disruption, cancer-related fatigue, cognitive impairment, psychosocial distress, and musculoskeletal symptoms in cancer patients receiving chemotherapy and radiation and cancer survivors...
February 1, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29338761/is-total-femoral-replacement-for-non-oncologic-and-oncologic-indications-a-safe-procedure-in-limb-preservation-surgery-a-single-center-experience-of-22-cases
#20
Andreas Toepfer, Norbert Harrasser, Isabel Petzschner, Florian Pohlig, Ulrich Lenze, Ludger Gerdesmeyer, Ruediger von Eisenhart-Rothe, Heinrich Mühlhofer, Christian Suren
BACKGROUND: Several surgical options for the reconstruction of massive bone defects have been described and include biologic methods with autografts and allografts, and the use of tumor endoprostheses (total femoral replacement, TFR). Several types of modular TFR are available, but nevertheless unpredictable outcomes and high complication rates have been described from most authors. The present study aims to compare results after TFR performed with modular total femur prosthesis MML (Fa...
January 16, 2018: European Journal of Medical Research
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