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Musculoskeletal Oncology

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https://www.readbyqxmd.com/read/29127246/non-oncologic-applications-of-pet-ct-and-pet-mr-in-musculoskeletal-orthopedic-and-rheumatologic-imaging-general-considerations-techniques-and-radiopharmaceuticals
#1
Ali Gholamrezanezhad, Kyle Basques, Ali Batouli, Mojtaba Olyaie, George Matcuk, Abass Alavi, Hossein Jadvar
Positron Emission Tomography (PET) is often underutilized in the field of musculoskeletal imaging, with key reasons including the excellent performance of conventional musculoskeletal MRI, the limited spatial resolution of PET, and the lack of reimbursement for PET for non-oncologic musculoskeletal indications. However, with improvements in PET/CT and PET/MR imaging over the last decade as well as an increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic patients...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29126579/chest-pain-as-a-manifestation-of-hypokalemia-in-a-pediatric-patient
#2
Jonathan S Schiffman
Patients presenting to the emergency department with chest pain are common and a cause of significant concern to patients and families and physicians alike. The causes of chest pain are myriad. These causes span diverse categories including cardiovascular, respiratory, abdominal and gastrointestinal, musculoskeletal, psychiatric, hematologic and oncologic, and neurologic Thull-Freedman (2010) [1]. These diverse etiologies present a diagnostic and management challenge to the ER physician who is tasked to minimize unnecessary diagnostics while not missing any significant disease...
November 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29081066/long-term-outcomes-of-cement-in-cement-technique-for-revision-endoprosthesis-surgery
#3
Nicholas M Bernthal, Vishal Hegde, Stephen D Zoller, Howard Y Park, Jason H Ghodasra, Daniel Johansen, Frederick Eilber, Fritz C Eilber, Chandhanarat Chandhanayingyong, Jeffrey J Eckardt
BACKGROUND AND OBJECTIVE: Cemented endoprosthetic reconstruction after resection of primary bone sarcomas has been a standard-of-care option for decades. With increased patient survival, the incidence of failed endoprostheses requiring revision surgery has increased. Revision of cemented endoprotheses by cementing into the existing cement mantle (CiC) is technically demanding. METHODS: This is a retrospective review of our endoprosthesis database of 512 consecutive cemented endoprosthetic reconstructions performed for oncologic diagnoses between 1980 and 2014...
October 29, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29079234/primary-tumor-and-tumor-like-lesions-of-bones-of-the-foot-single-center-experience-of-166-cases
#4
Devrim Özer, Osman Emre Aycan, Sait Turgay Er, Rahime Tanrıtanır, Yavuz Arıkan, Yavuz Selim Kabukçuoğlu
Primary bone tumors of the foot are rare lesions. The purpose of the present study was to evaluate the clinical manifestations, treatment modalities, and recurrences of various primary bone tumors of the foot from a specialized center for orthopedic oncology. Among 3681 musculoskeletal tumor cases, which were diagnosed and surgically treated in our hospital from 1983 to 2013, 166 primary tumor and tumor-like bone lesions of the foot (4.5%) were retrospectively reviewed regarding age, gender, localization, biopsy-revealed diagnosis, applied treatment modalities, follow-up period, and recurrence, if any...
November 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29068573/en-bloc-resection-and-prosthesis-implantation-to-treat-malignant-fibrous-histiocytoma-of-the-humerus
#5
Jun Sun, Ru-Ming Zhang, Yu-Xin Zheng
BACKGROUND: Malignant fibrous histiocytoma (MFH) of the bone is a rare tumor. Most studies comparing limb salvage and amputation have reported that limb salvage had no adverse effect on the long-term survival of patients. This study evaluates the oncological outcomes of limb salvage procedures that were used for 15 patients with MFH of the humerus. OBJECTIVES: The aim of this study was to assess the functional and oncological outcomes of patients with malignant fibrous histiocytoma of the humerus after en bloc resection and prosthesis implantation...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29067952/how-to-fill-the-cavity-after-curettage-of-giant-cell-tumors-around-the-knee-a-multicenter-analysis
#6
Kai Zheng, Xiu-Chun Yu, Yong-Cheng Hu, Zhen Wang, Su-Jia Wu, Zhao-Ming Ye
BACKGROUND: Intralesional excision with curettage is the standard method of giant cell tumor (GCT) treatment, but the ideal filling material after curettage remains controversial. The purpose of this study was to compare the oncological and functional outcomes which underwent cementation or bone grafting after GCT curettage around the knee. METHODS: We reported 136 cases with GCTs in distal femur or proximal tibia who accepted curettage from five clinical centers during the last 15 years...
November 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29044531/mesenchymal-chondrosarcoma-a-japanese-musculoskeletal-oncology-group-jmog-study-on-57-patients
#7
Yusuke Tsuda, Koichi Ogura, Michiyuki Hakozaki, Kazutaka Kikuta, Keisuke Ae, Hiroyuki Tsuchiya, Shintaro Iwata, Takafumi Ueda, Hirotaka Kawano, Akira Kawai
BACKGROUND: This study aimed to elucidate the clinical features and prognostic factors of mesenchymal chondrosarcoma (MCS) and investigate optimal treatment strategies. METHODS: Data from 57 patients with MCS were collected from a Japanese Musculoskeletal Oncology Group (JMOG) and retrospectively analyzed. RESULTS: Data from 29 males and 28 females were collected. Primary tumor sites were the head and neck (7 patients), trunk (35 patients), and extremities (15 patients)...
May 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29025611/carbon-fiber-reinforced-intramedullary-nailing-in-musculoskeletal-tumor-surgery-a-national-multicentric-experience-of-the-italian-orthopaedic-society-siot-bone-metastasis-study-group
#8
Andrea Piccioli, Raimondo Piana, Michele Lisanti, Alberto Di Martino, Barbara Rossi, Francesco Camnasio, Marco Gatti, Pietro Maniscalco, Franco Gherlinzoni, Maria Silvia Spinelli, Davide Maria Donati, Roberto Biagini, Rodolfo Capanna, Vincenzo Denaro
INTRODUCTION: Carbon fiber reinforced (CFR) implants have been proposed for the treatment of fractures or impending fractures of the long bones in the oncology patient. Aim of this study is to present the largest cohort of oncology patients operated by CFR nailing by the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group. METHODS: 53 adult oncology patients were operated on with a CFR-PEEK nail. All the data from adjuvants therapies were collected. Bone callus formation, response to radiotherapy, relapse or progression of the osteolysis were recorded...
October 2017: Injury
https://www.readbyqxmd.com/read/28990718/limb-sparing-sarcoma-reconstruction-with-functional-composite-thigh-flaps
#9
John T Stranix, Z-Hye Lee, Gretl Lam, Joshua Mirrer, Timothy Rapp, Pierre B Saadeh
INTRODUCTION: Innervated muscle transfer can improve functional outcomes after extensive limb-sparing sarcoma resections. We report our experience using composite thigh flaps for functional reconstruction of large oncologic extremity defects. PATIENTS AND METHODS: Between 2011 and 2014, four limb-sparing oncologic resections (3 lower extremities, 1 upper extremity) underwent immediate functional reconstruction with composite thigh free flaps in three males and one female...
October 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28988692/the-survey-on-cellular-and-tissue-engineered-therapies-in-europe-and-neighboring-eurasian-countries-in-2014-and-2015
#10
Hilary Ireland, Max H P Gay, Helen Baldomero, Barbara De Angelis, Hossein Baharvand, Mark W Lowdell, Jakob Passweg, Ivan Martin
BACKGROUND AIMS: With the support of five established scientific organizations, this report, the seventh of its kind, describes activity in Europe for the years 2014 and 2015 in the area of cellular and tissue-engineered therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis. METHODS: In 2015 [respectively 2014], 205 [276] teams from 32 countries responded to the cellular and tissue-engineered therapy survey; 178 [126] teams reported treating 3686 [2665] patients...
October 4, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28948491/acetabular-reconstruction-with-femoral-head-autograft-after-intraarticular-resection-of-periacetabular-tumors-is-durable-at-short-term-followup
#11
Xiaodong Tang, Wei Guo, Rongli Yang, Taiqiang Yan, Shun Tang, Dasen Li
BACKGROUND: Pelvic reconstruction after periacetabular tumor resection is technically difficult and characterized by a high complication rate. Although endoprosthetic replacement can result in immediate postoperative functional recovery, biologic reconstructions with autograft may provide an enhanced prognosis in patients with long-term survival; however, little has been published regarding this approach. We therefore wished to evaluate whether whole-bulk femoral head autograft that is not contaminated by tumor can be used to reconstruct segmental bone defects after intraarticular resection of periacetabular tumors...
December 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28947878/diagnostic-methods-for-detection-of-bone-metastases
#12
REVIEW
Bartosz Łukaszewski, Jerzy Nazar, Maciej Goch, Marta Łukaszewska, Adrian Stępiński, Mieczysława U Jurczyk
Skeletal metastases are severe complications in the course of cancer, and they indicate a worse prognosis. The use of modern imaging techniques allows rapid diagnosis of bone metastases. Properly selected diagnostic imaging (scintigraphy, positron emission tomography, whole body MRI) allows us to evaluate the number of metastatic foci in the skeletal system. Complementary imaging examinations (X-ray, computed tomography, magnetic resonance imaging) determine the extent of metastasis and its character: osteolytic, osteoblast, mixed)...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28945136/understanding-the-different-relationships-between-mood-and-sleep-disorders-in-several-groups-of-non-oncological-patients-with-chronic-pain
#13
B Ojeda, A Salazar, M J Calahorro, M Dueñas, J A Mico, H de Sola, I Failde
OBJECTIVE: To compare sleep dimensions in patients suffering from chronic pain of different origins, and with a group of pain-free subjects. To analyze the relationship between depression and/or anxiety and sleep disorders in musculoskeletal, neuropathic and fibromyalgia patients. METHODS: This cross-sectional study included patients diagnosed with neuropathic pain (NP) (N = 104), musculoskeletal pain (MSK) (N = 99) or fibromyalgia (FM) (N = 51), and pain free subjects (N = 72)...
September 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28876452/management-of-primary-malignant-bone-and-soft-tissue-tumors-of-foot-and-ankle-is-it-worth-salvaging
#14
Harzem Özger, Buğra Alpan, Osman Emre Aycan, Natig Valiyev, Mustafa Çağlar Kir, Fulya Ağaoğlu
BACKGROUND AND OBJECTIVE: Performing limb salvage with safe margins and preserving meaningful function is very difficult in the setting of primary malignant bone and soft tissue tumors due to the complex and constrained anatomy of the foot and ankle. The study aims to evaluate the efficacy of limb salvage procedures in terms of functional and oncological outcomes. METHODS: Clinical data of 48 patients, who underwent surgical treatment between 1992 and 2015 in our institution, were retrospectively analyzed...
September 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28860406/vascularised-fibular-grafts-for-reconstruction-of-extremity-bone-defects-after-resection-of-bone-and-soft-tissue-tumours-a-single-institutional-study-of-49-patients
#15
M Emori, M Kaya, H Irifune, N Takahashi, J Shimizu, E Mizushima, Y Murahashi, T Yamashita
AIMS: The aims of this study were to analyse the long-term outcome of vascularised fibular graft (VFG) reconstruction after tumour resection and to evaluate the usefulness of the method. PATIENTS AND METHODS: We retrospectively reviewed 49 patients who had undergone resection of a sarcoma and reconstruction using a VFG between 1988 and 2015. Their mean follow-up was 98 months (5 to 317). Reconstruction was with an osteochondral graft (n = 13), intercalary graft (n = 12), inlay graft (n = 4), or resection arthrodesis (n = 20)...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28856514/moving-forward-through-consensus-a-modified-delphi-approach-to-determine-the-top-research-priorities-in-orthopaedic-oncology
#16
Patricia Jacqueline Schneider, Nathan Evaniew, Paula McKay, Michelle Ghert
BACKGROUND: Several challenges presently impede the conduct of prospective clinical studies in orthopaedic oncology, including limited financial resources to support their associated costs and inadequate patient volume at most single institutions. This study was conducted to prioritize research questions within the field so that the Musculoskeletal Tumor Society (MSTS), and other relevant professional societies, can direct the limited human and fiscal resources available to address the priorities that the stakeholders involved believe will have the most meaningful impact on orthopaedic oncology patient care...
December 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28843590/expanding-the-borders-image-guided-procedures-for-the-treatment-of-musculoskeletal-tumors
#17
J Garnon, G Koch, J Caudrelier, G Tsoumakidou, R L Cazzato, A Gangi
Interventional radiology has revolutionized the local management of bone tumours, offering new minimal invasive alternatives to surgery and radiotherapy. Its role has continuously increased over the past years for the treatment of benign tumors and also of some malignant ones, especially in palliative situations. The development of protective techniques and new ablative technologies, such as cryoablation, contributes to expand the role of the interventional radiologist to new fields of applications in musculoskeletal oncology...
September 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28830234/a-national-uk-survey-of-radiology-trainees-special-interest-choices-what-and-why
#18
Nassim Parvizi, Shaheel Bhuva
OBJECTIVES: A national survey was designed to better understand factors influencing special interest choices, future aspirations of UK radiology trainees and perceptions of breast radiology. METHODS: A SurveyMonkey questionnaire was developed and distributed to all radiology trainees in the UK through the British Institute of Radiology, RCR Junior Radiologists Forum and by directly contacting UK training schemes as well as by social media between December 2015 and January 2016...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28827055/prediction-of-muscle-strength-and-postoperative-function-after-knee-flexor-muscle-resection-for-soft-tissue-sarcoma-of-the-lower-limbs
#19
A Tanaka, Y Yoshimura, K Aoki, M Okamoto, M Kito, S Suzuki, A Takazawa, T Ishida, H Kato
INTRODUCTION: Oncological margins and prognosis are the most important factors for operative planning of soft tissue sarcomas, but prediction of postoperative function is also necessary. The purpose of this study was to predict the knee flexion strength and postoperative function after knee flexor muscle resection for soft tissue sarcoma of the lower limbs. MATERIALS AND METHODS: Seventeen patients underwent knee flexor muscle resection for soft tissue sarcoma of the lower limbs between 1991 and 2015...
August 4, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28753225/review-of-dynamic-contrast-enhanced-mri-technical-aspects-and-applications-in-the-musculoskeletal-system
#20
REVIEW
Parvinder Sujlana, Jan Skrok, Laura M Fayad
Although postcontrast imaging has been used for many years in musculoskeletal imaging, dynamic contrast enhanced (DCE) MRI is not routinely used in many centers around the world. Unlike conventional contrast-enhanced sequences, DCE-MRI allows the evaluation of the temporal pattern of enhancement in the musculoskeletal system, perhaps best known for its use in oncologic applications (such as differentiating benign from malignant tumors, evaluating for treatment response after neoadjuvant chemotherapy, and differentiating postsurgical changes from residual tumor)...
July 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
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