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Musculoskeletal Oncology

Yi-Chou Chen, Po-Kuei Wu, Cheng-Fong Chen, Wei-Ming Chen
BACKGROUND: The aim of this study was to review the experience of surgical treatment of low-grade chondrosarcoma and to assess the long-term oncological and functional outcomes between intralesional curettage and wide excision. METHODS: We included 11 patients with central low-grade chondrosarcoma lesions treated with intralesional curettage or wide excision from 1998 to 2013. Seven patients were treated with intralesional curettage and local adjuvant treatment (Group A), and four patients were treated with wide excision and reconstructive surgery (Group B)...
November 23, 2016: Journal of the Chinese Medical Association: JCMA
Viren S Vasudeva, Alexander E Ropper, Samuel Rodriguez, Kyle C Wu, John H Chi
En bloc resection of tumors involving the spinal column is technically challenging and is associated with high morbidity to the patient due to the proximity of critical neurological and vascular structures and the destabilizing nature of this surgery. Nevertheless, evidence has shown improved progression-free survival with en bloc resection for certain low-grade malignant and aggressive benign musculoskeletal tumors. To avoid the morbidity of en bloc spondylectomy in patients with tumors localized to the lateral and posterolateral spinal column, the authors have found that the goals of surgery can be accomplished through a contralateral osteotomy of the pedicle and posterolateral elements for en bloc resection (COPPER)...
October 28, 2016: Journal of Neurosurgery. Spine
Jungo Imanishi, Yasuo Yazawa, Tsuyoshi Saito, Michio Shimizu, Hiroyuki Kawashima, Keisuke Ae, Akihiko Matsumine, Tomoaki Torigoe, Hideshi Sugiura, Susumu Joyama
No abstract text is available yet for this article.
December 2016: International Journal of Clinical Oncology
Shiromani Janki, Evalyn E A P Mulder, Jan N M IJzermans, T C Khe Tran
BACKGROUND: Since the introduction of minimally invasive surgery, surgeons appear to be experiencing more occupational musculoskeletal injuries. The aim of this study is to investigate the current frequency and effects of occupational musculoskeletal injuries on work absence. METHODS: An online questionnaire was conducted among all surgeons affiliated to the Dutch Society for Endoscopic Surgery, Gastrointestinal Surgery, and Surgical Oncology. In addition, this survey was conducted among surgeons, gynaecologists, and urologists of one cluster of training hospitals in the Netherlands...
October 17, 2016: Surgical Endoscopy
Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka
BACKGROUND: Historically, local control of recurrent sarcomas has been limited to radiotherapy when surgical re-resection is not feasible. For metastatic carcinomas to the bone or soft tissue, radiotherapy and some interventional radiology treatment along with other systemic therapies have been widely advocated due to the possibility of disseminated disease. These techniques are effective in alleviating pain and achieving local control for some tumor types, but it has not been effective for prolonged local control of most tumors...
October 13, 2016: BMC Cancer
Rachel K Voss, Yi-Ju Chiang, Kate D Cromwell, Diana L Urbauer, Jeffrey E Lee, Janice N Cormier, Chee-Chee H Stucky
BACKGROUND: Occupational symptoms and injuries incurred over a surgical career are underreported yet impact daily surgical practice. We assessed the frequency, consequences, and risk factors for occupational injury in oncologic surgeons and evaluated the feasibility of intraoperative foot mat use to mitigate occupational symptoms. STUDY DESIGN: Oncologic surgeons completed a survey of demographic information and occupational symptoms and injuries. Multivariate logistic regression was used to identify factors associated with occupational symptoms and injuries...
September 29, 2016: Journal of the American College of Surgeons
F Donati, G Di Giacomo, S D'Adamio, A Ziranu, S Careri, Ma Rosa, G Maccauro
Silver coating has demonstrated good antimicrobial activity and low toxicity. Silver-coated megaprostheses have been introduced in oncological musculoskeletal surgery considering the high rate of infection. We conducted a retrospective analysis on 68 cases of primary or metastatic bone tumors, affecting the proximal femur, treated between 2005 and 2016 with wide margins resection and tumor implants reconstruction. All patients were treated by the same surgeon, with antibiotic prophylaxis according to a standard protocol...
2016: BioMed Research International
Boris Michael Holzapfel, Ferdinand Wagner, Laure Christine Martine, Stephan Reppenhagen, Maximilian Rudert, Michael Schuetz, Jim Denham, Jan-Thorsten Schantz, Dietmar Werner Hutmacher
Currently used surgical techniques to reconstruct tissue defects after resection of musculoskeletal tumours are associated with high complication rates. This drives a strong demand for innovative therapeutic concepts that are able to improve the clinical outcomes of patients suffering from bone and soft tissue tumours. Tissue engineering and regenerative medicine (TE&RM) provides a technology platform based on biochemical, molecular, cellular and biomaterials modules to selectively direct tissue healing processes for improved defect regeneration...
September 2016: Cancer Metastasis Reviews
Selcuk Seber, Dilek Solmaz, Tarkan Yetisyigit
PURPOSE: Antihormonal treatment is an effective therapy in the adjuvant setting. However, musculoskeletal pain is a common adverse effect encountered in patients receiving this treatment. We aimed to evaluate the risk factors for the development of antihormonal treatment-associated musculoskeletal pain (AHAMP) and its impact on the health-related quality of life (HRQOL). PATIENTS AND METHODS: A cross-sectional survey of 78 consecutive breast cancer patients receiving adjuvant antihormonal treatment for early-stage breast cancer in an academic medical oncology clinic was conducted...
2016: OncoTargets and Therapy
Ashish Gulia, Suman Byregowda, Pankaj Kumar Panda
Patients in advanced stages of illness trajectories with local and widespread musculoskeletal incurable malignancies, either treatment naive or having recurrence are referred to the palliative care clinic to relieve various disease-related symptoms and to improve the quality of life. Palliative care is a specialized medicine that offers treatment to the disease-specific symptoms, places emphasis on the psychosocial and spiritual aspects of life and help the patients and their family to cope with advance stage cancer in a stronger and reasonable way...
July 2016: Indian Journal of Palliative Care
Rodolfo Capanna, Francesco Muratori, Francesco R Campo, Antonio D'Arienzo, Filippo Frenos, Giovanni Beltrami, Guido Scoccianti, Pierluigi Cuomo, Andrea Piccioli, Daniel A Müller
BACKGROUND: Reconstruction of large bone defects around the elbow joint is surgically demanding due to sparse soft tissue coverage, complex biomechanics and the close proximity to neurovascular structures. Modular megaprostheses are established reconstruction tools for the elbow, but only small case series have been reported in the literature. METHODS: Thirty-six patients who underwent reconstruction of the elbow joint with a modular megaprosthesis were reviewed retrospectively...
August 18, 2016: Injury
Tomoki Nakamura, Akihiko Matsumine, Satoshi Yamada, Satoshi Tsukushi, Katsuhisa Kawanami, Takatoshi Ohno, Hirohisa Katagiri, Hideshi Sugiura, Kenji Yamada, Yoshihisa Yamada, Akihiro Sudo, Yoshihiro Nishida
The oncological outcome after lung metastasis in patients with chondrosarcoma of the extremities has not been reported. Between June 2000 and June 2013, 179 patients with chondrosarcoma in the extremities were treated at eleven hospitals. Twenty consecutive patients (11.2%) developed lung metastases after initial treatment of primary chondrosarcoma in the extremities. We investigated the oncological outcome of 20 chondrosarcoma patients with lung metastasis. There were 14 males and six females with a mean age of 49 years...
2016: OncoTargets and Therapy
Kyle R Duchman, Benjamin J Miller
BACKGROUND: The majority of orthopaedic trainees pursue additional subspecialty training at the conclusion of residency. Although national trends indicate that fellowship-trained surgeons are more frequently performing cases in their defined subspecialties, this may not be the case for recently trained tumor fellows. Prior work has established that low tumor case volume is a significant stressor for recently trained tumor fellows. Given the relative rarity of musculoskeletal tumors, it is important for prospective trainees to have clear expectations for the proportion of specialty-specific procedures early during their careers...
August 10, 2016: Clinical Orthopaedics and related Research
Lucinda C C Gosling, Alison B Rushton
OBJECTIVES: The aim of this study was to identify the symptom presentation of adult knee primary bone tumours from onset to Consultant diagnosis, from combined patient and healthcare professional perspectives. MATERIALS AND METHODS: A qualitative study using in-depth semi-structured interviews recruited a purposive sample of adult patients with a knee primary bone tumour (n = 8) and healthcare professionals with expertise in orthopaedic oncology (n = 6). Following informed consent, recorded interviews explored participants' experiences of symptom presentation...
July 17, 2016: Manual Therapy
David D Greenberg, Brooke Crawford
Background. Surveillance is crucial to oncology, yet there is scant evidence to guide strategies. Purpose. This survey identified sarcoma surveillance strategies for Musculoskeletal Tumor Society (MSTS) members and rationales behind them. Understanding current practice should facilitate studies to generate evidence-based surveillance protocols. Methods. Permission was granted by the Research and Executive Committee of the MSTS to survey members on surveillance strategies. First, the questionnaire requested demographic and clinical practice information...
2016: Sarcoma
Akihiko Takeuchi, Hiroyuki Tsuchiya, Takeshi Ishii, Yoshihiro Nishida, Satoshi Abe, Akihiko Matsumine, Akira Kawai, Kenichi Yoshimura, Takafumi Ueda
BACKGROUND: Giant cell tumor of the bone (GCTB) is classified as an intermediate, locally aggressive but rarely metastasizing tumor. The mainstay of treatment for the treatment of GCTB had been the surgical removal until an anti- receptor activator of nuclear factor-kappa B ligands (RANKL) antibody denosumab was developed. And favorable responses and the possibility of surgical downstaging have been reported. However, the long-term outcome of denosumab has not yet been confirmed and moreover the long-term clinical outcome after the recurrence of GCTB in the era before molecular target therapy is still uncertain...
2016: BMC Musculoskeletal Disorders
Yi-Dan Zhang, Wei Guo, Rong-Li Yang, Xiao-Dong Tang, Tai-Qiang Yan, Tao Ji
OBJECTIVE: To introduce a new classification of Enneking type IV pelvic tumors involving the sacrum and a corresponding system of standardized surgical approaches and procedures for resection of such tumors, and to investigate the feasibility and therapeutic effect of the new system. METHODS: Data on 59 patients treated between February 2003 and February 2013 by standardized surgical approaches and procedures were retrospectively reviewed. The study subjects comprised 28 male and 31 female patients with a mean age at diagnosis of 36 years (range, 2-72 years)...
May 2016: Orthopaedic Surgery
Matthew T Houdek, Chad D Watts, Cody C Wyles, Peter S Rose, Michael J Taunton, Franklin H Sim
BACKGROUND: Cemented endoprosthetic replacement is an option for reconstruction of the proximal femur to achieve limb salvage. Existing outcome studies combine benign and malignant conditions, or group endoprostheses from multiple areas into one cohort. We sought to examine a series of endoprosthetic replacements of the proximal femur for a malignant process. METHODS: We reviewed 204 patients who underwent an endoprosthesis for a malignant process of the proximal femur with at least 2-year follow-up...
September 2016: Journal of Surgical Oncology
Maria G Benedetti, Silayan Erfe Delayon, Marco Colangeli, Federica Parisini, Stefano Ferrari, Marco Manfrini, Isabella Springhetti
BACKGROUND: Rehabilitation plays an important role in improving functional outcome in patients operated on musculoskeletal tumors. Literature in the field is scarce and the specific needs for rehabilitation of these patients are still unknown. AIM: To analyze the rehabilitation needs of patients with primary malignant musculoskeletal tumours. DESIGN: Observational, longitudinal study on both inpatient and outpatient operated on musculoskeletal tumours...
June 28, 2016: European Journal of Physical and Rehabilitation Medicine
Tomoaki Mori, Robert Nakayama, Makoto Endo, Hiroaki Hiraga, Masato Tomita, Naomasa Fukase, Eisuke Kobayashi, Akira Kawai, Takafumi Ueda, Hideo Morioka
BACKGROUND: Leiomyosarcoma of bone (LMSoB) is a rare malignant bone tumor. This multicenter retrospective study was conducted to investigate the diagnosis and the clinical outcome of primary LMSoB in Japan. METHODS: Forty-eight patients (average age: 52 years [range 14-88 years]) with primary LMSoB who were treated at registered institutes in Japan between 1991 and 2014 were recruited. The median follow-up period was 44 months (range: 2-273). RESULTS: The 5-year overall survival rates and disease-free survival rates were 78...
September 2016: Journal of Surgical Oncology
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