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selenium nanoparticle

Snober Ahmed, John Brockgreitens, Ke Xu, Abdennour Abbas
With increasing biomedical and engineering applications of selenium nanospheres (SeNS), new efficient methods are needed for the synthesis and long-term preservation of these nanomaterials. Currently, SeNS are mostly produced through the biosynthesis route using microorganisms or by using wet chemical reduction, both of which have several limitations in terms of nanoparticle size, yield, production time and long-term stability of the nanoparticles. Here, we introduce a novel approach for rapid synthesis and long-term preservation of SeNS on a solid microporous support by combining a mild hydrothermal process with chemical reduction...
October 17, 2016: Nanotechnology
Balakrishna Ananthoju, Jeotikanta Mohapatra, Manoj K Jangid, D Bahadur, N V Medhekar, M Aslam
Cations and anions are replaced with Fe, Mn, and Se in CZTS in order to control the formations of the secondary phase, the band gap, and the micro structure of Cu2ZnSnS4. We demonstrate a simplified synthesis strategy for a range of quaternary chalcogenide nanoparticles such as Cu2ZnSnS4 (CZTS), Cu2FeSnS4 (CFTS), Cu2MnSnS4 (CMTS), Cu2ZnSnSe4 (CZTSe), and Cu2ZnSn(S0.5Se0.5)4 (CZTSSe) by thermolysis of metal chloride precursors using long chain amine molecules. It is observed that the crystal structure, band gap and micro structure of the CZTS thin films are affected by the substitution of anion/cations...
October 17, 2016: Scientific Reports
Jacob Barlow, Kevin Gozzi, Chase P Kelley, Benjamin M Geilich, Thomas J Webster, Yunrong Chai, Srinivas Sridhar, Anne L van de Ven
Encapsulating bacteria within constrained microenvironments can promote the manifestation of specialized behaviors. Using double-emulsion droplet-generating microfluidic synthesis, live Bacillus subtilis bacteria were encapsulated in a semi-permeable membrane composed of poly(ethylene glycol)-b-poly(D,L-lactic acid) (mPEG-PDLLA). This polymer membrane was sufficiently permeable to permit exponential bacterial growth, metabolite-induced gene expression, and rapid biofilm growth. The biodegradable microparticles retained structural integrity for several days and could be successfully degraded with time or sustained bacterial activity...
October 15, 2016: Applied Microbiology and Biotechnology
Elena P Vetchinkina, Ekaterina A Loshchinina, Ilya R Vodolazov, Viktor F Kursky, Lev A Dykman, Valentina E Nikitina
The work shows the ability of cultured Basidiomycetes of different taxonomic groups-Lentinus edodes, Pleurotus ostreatus, Ganoderma lucidum, and Grifola frondosa-to recover gold, silver, selenium, and silicon, to elemental state with nanoparticles formation. It examines the effect of these metal and metalloid compounds on the parameters of growth and accumulation of biomass; the optimal cultivation conditions and concentrations of the studied ion-containing compounds for recovery of nanoparticles have been identified...
October 7, 2016: Applied Microbiology and Biotechnology
Nazanin Seyed Khoei, Silvia Lampis, Emanuele Zonaro, Kim Yrjälä, Paolo Bernardi, Giovanni Vallini
Microorganisms capable of transforming toxic selenium oxyanions into non-toxic elemental selenium (Se°) may be considered as biocatalysts for the production of selenium nanoparticles (SeNPs), eventually exploitable in different biotechnological applications. Two Burkholderia fungorum strains (B. fungorum DBT1 and B. fungorum 95) were monitored during their growth for both capacity and efficiency of selenite (SeO3(2-)) reduction and elemental selenium formation. Both strains are environmental isolates in origin: B...
October 4, 2016: New Biotechnology
Arin Bhattacharjee, Abhishek Basu, Jaydip Biswas, Tuhinadri Sen, Sudin Bhattacharya
Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich's ascites carcinoma (EAC) cells...
October 1, 2016: Molecular and Cellular Biochemistry
Zuzana Gajdosechova, Mohammed M Lawan, Dagmar S Urgast, Andrea Raab, Kirk G Scheckel, Enzo Lombi, Peter M Kopittke, Katrin Loeschner, Erik H Larsen, Glenn Woods, Andrew Brownlow, Fiona L Read, Jörg Feldmann, Eva M Krupp
To understand the biochemistry of methylmercury (MeHg) that leads to the formation of mercury-selenium (Hg-Se) clusters is a long outstanding challenge that promises to deepen our knowledge of MeHg detoxification and the role Se plays in this process. Here, we show that mercury selenide (HgSe) nanoparticles in the liver and brain of long-finned pilot whales are attached to Se-rich structures and possibly act as a nucleation point for the formation of large Se-Hg clusters, which can grow with age to over 5 μm in size...
September 28, 2016: Scientific Reports
Peng Bao, Ke-Qing Xiao, Hui-Jiao Wang, Hao Xu, Peng-Peng Xu, Yan Jia, Max M Häggblom, Yong-Guan Zhu
A novel nitrate- and selenite reducing bacterium strain ZYK(T) was isolated from a rice paddy soil in Dehong, Yunnan, China. Strain ZYK(T) is a facultative anaerobe and grows in up to 150, 000 ppm O2. The comparative genomics analysis of strain ZYK(T) implies that it shares more orthologues with B. subtilis subsp. subtilis NCIB 3610(T) (ANIm values, 85.4-86.7%) than with B. azotoformans NBRC 15712(T) (ANIm values, 84.4-84.7%), although B. azotoformans NBRC 15712(T) (96.3% 16S rRNA gene sequence similarity) is the closest Bacillus species according to 16S rRNA gene comparison...
September 28, 2016: Scientific Reports
Soroush Safa, Gholamali Moghaddam, Raziallah Jafari Jozani, Hossein Daghigh Kia, Hossein Janmohammadi
This study was conducted to determine the combined effects of adding vitamin E (VitE) and selenium nanoparticle (Nano-Se) as antioxidant supplements to rooster semen extender for freezing. Semen samples were collected from 12 White Leghorn roosters and pooled. Subsequently, the samples were divided into nine equal groups using modified Beltsville extender. Extenders were supplemented with either two amounts of VitE (5 and 10μg/mL) or two amounts of Nano-Se (1% and 2%) or a combination of both VitE and Nano-Se, and no antioxidants extender (control group)...
September 15, 2016: Animal Reproduction Science
Yuanqing Tan, Rong Yao, Rui Wang, Dan Wang, Gejiao Wang, Shixue Zheng
BACKGROUND: Selenium (Se) is an essential trace element in living systems. Microorganisms play a pivotal role in the selenium cycle both in life and in environment. Different bacterial strains are able to reduce Se(IV) (selenite) and (or) Se(VI) (selenate) to less toxic Se(0) with the formation of Se nanoparticles (SeNPs). The biogenic SeNPs have exhibited promising application prospects in medicine, biosensors and environmental remediation. These microorganisms might be explored as potential biofactories for synthesis of metal(loid) nanoparticles...
2016: Microbial Cell Factories
L Kamrani Moghaddam, S Ramezani Paschepari, M A Zaimy, A Abdalaian, A Jebali
The aim of this study was to investigate the effect of hexagonal selenium nanoparticles modified by SiRNA (HSNM-SiRNA) to inhibit epidermal growth factor receptor (EGFR) signaling in Human non-small-cell lung cancer (NSCLC). After synthesis, HSNM-SiRNA and HSNs were separately exposed to NSCLC cell lines (A549, H1299, H520, and H1975), and incubated for 6 h at 37 °C. Next, the expression of NFKB, MYC, STAT, ELK1, and GAPDH was evaluated by western blot and real-time PCR. The percentage of apoptotic cells and cell cycle progression were measured when exposed to HSNM-SiRNA and HSNs...
September 2016: Cancer Gene Therapy
Murray C Killingsworth, Yuri V Bobryshev
A method is described whereby quantum dot (QD) nanoparticles can be used for correlative immunocytochemical studies of human pathology tissue using widefield fluorescence light microscopy and transmission electron microscopy (TEM). To demonstrate the protocol we have immunolabeled ultrathin epoxy sections of human somatostatinoma tumor using a primary antibody to somatostatin, followed by a biotinylated secondary antibody and visualization with streptavidin conjugated 585 nm cadmium-selenium (CdSe) quantum dots (QDs)...
2016: Journal of Visualized Experiments: JoVE
G Guisbiers, Q Wang, E Khachatryan, L C Mimun, R Mendoza-Cruz, P Larese-Casanova, T J Webster, K L Nash
Nosocomial diseases are mainly caused by two common pathogens, Escherichia coli and Staphylococcus aureus, which are becoming more and more resistant to conventional antibiotics. Therefore, it is becoming increasingly necessary to find other alternative treatments than commonly utilized drugs. A promising strategy is to use nanomaterials such as selenium nanoparticles. However, the ability to produce nanoparticles free of any contamination is very challenging, especially for nano-medical applications. This paper reports the successful synthesis of pure selenium nanoparticles by laser ablation in water and determines the minimal concentration required for ~50% inhibition of either E...
2016: International Journal of Nanomedicine
Urarika Luesakul, Seamkwan Komenek, Songchan Puthong, Nongnuj Muangsin
The ability to control the morphology of nanoparticles by molecular design and synthesis is gaining increasing attention for achieving improved unique properties. In this work, we designed the chemical structure of a stabilizer for controlling the shape of selenium nanoparticles (SeNPs) via a self-assembly process. When folic acid-gallic acid-N,N,N-trimethyl chitosan (FA-GA-TMC) was used as a stabilizer, SeNPs were observed to self-organize into cubic-like structures with an average size of approximately 300nm...
November 20, 2016: Carbohydrate Polymers
Jipeng Wang, Bo Wang, Dan Zhang, Yanhong Wu
Recently, selenium (Se) enriched mushrooms have been exploited as dietary Se supplements, but our knowledge of the metabolic process during the Se enrichment process is far from complete. In this study, the uptake, tolerance and reduction of selenite in a widely cultivated mushroom, Flammulina velutipes, was investigated. The results showed that pH variation (from 5.5-7.5), metabolic inhibitor (0.1 mM 2,4-DNP) and P or S starvation led to 11-26% decreases in the selenite uptake rate of F. velutipes. This indicates that a minor portion of the selenite uptake was metabolism dependent, whereas a carrier-facilitated passive transport may be crucial...
2016: PeerJ
Christopher E Hassan, Thomas J Webster
Given their low toxicity and natural presence in the human diet, selenium nanoparticles have been established as potential candidates for the treatment of numerous cancers. Red-allotrope selenium nanoparticles (rSeNPs) were synthesized and characterized in this study. Head and neck squamous cell carcinoma (HNSCC) and human dermal fibroblast (HDF) cells were cultured and exposed to rSeNPs at concentrations ranging from 0.01 to 100 μg rSeNP/mL media for 1-3 days. The toxicity of rSeNP toward HNSCC and HDFs was analyzed...
2016: International Journal of Nanomedicine
Wenwen Liu, Negar H Golshan, Xuliang Deng, Daniel J Hickey, Katherine Zeimer, Hongyi Li, Thomas J Webster
Since implants often fail due to infection and uncontrolled inflammatory responses, we designed an in vitro study to investigate the antibacterial and anti-inflammatory properties of titanium dioxide nanotubes (TNTs) incorporated with selenium nanoparticles (SeNPs). Selenium incorporation was achieved by the reaction of sodium selenite (Na2SeO3) with glutathione (GSH) under a vacuum in the presence of TNTs. Two types of bacteria and macrophages were cultured on the samples to determine their respective antibacterial and anti-inflammatory properties...
August 25, 2016: Nanoscale
Erika J Espinosa-Ortiz, Manisha Shakya, Rohan Jain, Eldon R Rene, Eric D van Hullebusch, Piet N L Lens
The use of a novel hybrid biosorbent, elemental selenium nanoparticles (nSe(0)) immobilized in pellets of Phanerochaete chrysosporium, to remove Zn from aqueous solutions was investigated. Fungal pellets containing nSe(0) (nSe(0)-pellets) showed to be better biosorbents as they removed more Zn (88.1 ± 5.3 %) compared to Se-free fungal pellets (56.2 ± 2.8 %) at pH 4.5 and an initial Zn concentration of 10 mg L(-1). The enhanced sorption capacity of nSe(0)-pellets was attributed to a higher concentration of sorption sites resulting in a more negative surface charge density, as determined by analysis of the potentiometric titration data...
August 13, 2016: Environmental Science and Pollution Research International
Tianyu Li, Feng Li, Wentian Xiang, Yu Yi, Yuyan Chen, Liang Cheng, Zhuang Liu, Huaping Xu
Selenium has attracted increasing interest in recent decades because of the function of regulating the redox balance in the human body. However, biomedical studies of selenium are still limited. Gold nanoparticles (AuNPs), typically prepared by a first reduction step followed by a second stabilization step, are widely applied in biomedical studies. However, their own anticancer activity is less studied. Here, we report 2 nm AuNPs with significant anticancer activity (IC50 = 20 μM) that is stabilized by a selenium-containing amphiphile EGSe-tMe...
August 31, 2016: ACS Applied Materials & Interfaces
Ge Wang, Yuming Guo, Gai Yang, Lin Yang, Xiaoming Ma, Kui Wang, Lin Zhu, Jiaojiao Sun, Xiaobing Wang, Hua Zhang
The present study was (i) to prepare two types of selenium nanoparticles, namely an amorphous form of selenium quantum dots (A-SeQDs) and a crystalline form of selenium quantum dots (C-SeQDs); and (ii) to investigate the nano-bio interactions of A-SeQDs and C-SeQDs in MCF-7, HepG2, HeLa, NIH/3T3, L929 cells and BRL-3A cells. It was found that A-SeQDs could induce the mitochondria-mediated apoptosis, necrosis and death of cells, while C-SeQDs had much weaker effects. This polymorphs-dependent anti-proliferative activity of nano-selenium was scarcely reported...
2016: Scientific Reports
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