keyword
MENU ▼
Read by QxMD icon Read
search

selenium nanoparticle

keyword
https://www.readbyqxmd.com/read/28440710/selenium-nanoparticles-potential-in-cancer-gene-and-drug-delivery
#1
Fiona Maiyo, Moganavelli Singh
In recent decades, colloidal selenium nanoparticles have emerged as exceptional selenium species with reported chemopreventative and therapeutic properties. This has sparked widespread interest in their use as a carrier of therapeutic agents with results displaying synergistic effects of selenium with its therapeutic cargo and improved anticancer activity. Functionalization remains a critical step in selenium nanoparticles' development for application in gene or drug delivery. In this review, we highlight recent developments in the synthesis and functionalization strategies of selenium nanoparticles used in cancer drug and gene delivery systems...
April 25, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28406025/biogenic-nanoselenium-particles-effectively-attenuate-oxidative-stress-induced-intestinal-epithelial-barrier-injury-by-activating-the-nrf2-antioxidant-pathway
#2
Deguang Song, Yuanzhi Cheng, Xiaoxiao Li, Fengqin Wang, Zeqing Lu, Xiao Xiao, Yizhen Wang
In the present study, a new form of selenium nanoparticle (biogenic nanoselenium (BNS) particles) was synthesized using bacteria. The protection of BNS particles against oxidative stress-induced intestinal barrier dysfunction and the inherent mechanisms of this process were investigated, and selenomethionine (SeMet) and chemically synthesized nanoselenium (Nano-Se) particles were used for comparison. Characterization of BNS particles revealed that they were monodispersed and homogeneous spheres, with an average size of 139...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28386534/scaffold-of-selenium-nanovectors-and-honey-phytochemicals-for-inhibition-of-pseudomonas-aeruginosa-quorum-sensing-and-biofilm-formation
#3
Prateeksha, Braj R Singh, M Shoeb, S Sharma, A H Naqvi, Vijai K Gupta, Brahma N Singh
Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen Pseudomonas aeruginosa to regulate virulence and biofilm formation. However, lower water solubility and inadequate bioavailability remains major concerns of these therapeutic polyphenols. Its therapeutic index can be improved by using nano-carrier systems to target QS signaling potently. In the present study, we fabricated a unique drug delivery system comprising selenium nanoparticles (SeNPs; non-viral vectors) and polyphenols of honey (HP) for enhancement of anti-QS activity of HP against P...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28378115/tracing-tellurium-and-its-nanostructures-in-biology
#4
REVIEW
Bijan Zare, Mohammad Nami, Ahmad-Reza Shahverdi
Tellurium (Te) is a semimetal rare element in nature. Together with oxygen, sulfur (S), and selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te applications continued to emerge in different fields including metallurgy, glass industry, electronics, and applied chemical industries. Along these lines, Te has recently attracted research attention in various fields. Though Te exists in biologic organisms such as microbes, yeast, and human body, its importance and role and some of its potential implications have long been ignored...
April 4, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28356733/a-novel-selective-vpac2-agonist-peptide-conjugated-chitosan-modified-selenium-nanoparticles-with-enhanced-anti-type-2-diabetes-synergy-effects
#5
Shao-Jun Zhao, De-Hua Wang, Yan-Wei Li, Lei Han, Xing Xiao, Min Ma, David Chi-Cheong Wan, An Hong, Yi Ma
A novel neuroendocrine peptide, pituitary adenylate cyclase activating peptide (PACAP), was found to have an important role in carbohydrate or lipid metabolism and was susceptible to dipeptidyl peptidase IV degradation. It can not only mediate glucose-dependent insulin secretion and lower blood glucose by activating VPAC2 receptor, but also raise blood glucose by promoting glucagon production by VPAC1 receptor activation. Therefore, its therapeutic application is restricted by the exceedingly short-acting half-life and the stimulatory function for glycogenolysis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28326763/gold-nanoparticle-based-colorimetric-assay-for-selenium-detection-via-hydride-generation
#6
Guoming Cao, Fujian Xu, Shanling Wang, Kailai Xu, Xiandeng Hou, Peng Wu
Gold nanoparticles (AuNPs)-based colorimetric assays are of particular interest since molecular events can be easily read out with the color changes of AuNPs by the naked eye. However, the molecular recognitions occur almost exclusively in the liquid phase (i.e., the interaction between target analytes and AuNPs is always proceeded in the presence of the sample matrix). Since the aggregation of the unmodified AuNPs is prone to be influenced by the ionic strength of the solution, sample matrix will cause undesirable interference...
March 31, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28274870/construction-of-a-cordyceps-sinensis-exopolysaccharide-conjugated-selenium-nanoparticles-and-enhancement-of-their-antioxidant-activities
#7
Yidong Xiao, Qilin Huang, Zhaomin Zheng, Han Guan, Shiyu Liu
A Cordyceps sinensis exopolysaccharide (EPS)-conjugated selenium nanoparticles (SeNPs) were successfully constructed through the reduction of SeO3(2-). The EPS-SeNPs were characterized in terms of formation, morphology, size, Se distribution and phase by UV-vis, FT-IR, transmission electron microscopy (TEM), dynamic light scattering (DLS), energy dispersive X-ray (EDX) and wide angle X-ray diffraction (WAXD) measurements. Results revealed that the SeNPs conjugated to EPS were amorphous and could be well dispersed at a size range of 80-125nm...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28270147/selenium-nanoparticles-decorated-with-ulva-lactuca-polysaccharide-potentially-attenuate-colitis-by-inhibiting-nf-%C3%AE%C2%BAb-mediated-hyper-inflammation
#8
Chenghui Zhu, Shuimei Zhang, Chengwei Song, Yibo Zhang, Qinjie Ling, Peter R Hoffmann, Jun Li, Tianfeng Chen, Wenjie Zheng, Zhi Huang
BACKGROUND: Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the digestive tract. Se nanoparticles (SeNPs) exhibit anti-inflammatory activity accompanied by low toxicity, especially when decorated with natural biological compounds. Herein, we explored the beneficial effects of SeNPs decorated with Ulva lactuca polysaccharide (ULP) in mice subjected to the acute colitis model...
March 7, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28267598/redox-responsive-mesoporous-selenium-delivery-of-doxorubicin-targets-mcf-7-cells-and-synergistically-enhances-its-anti-tumor-activity
#9
Shuang Zhao, Qianqian Yu, Jiali Pan, Yanhui Zhou, Chengwen Cao, Jian-Ming Ouyang, Jie Liu
To reduce the side effects and enhance the anti-tumor activities of anticancer drugs in the clinic, the use of nano mesoporous materials, with mesoporous silica (MSN) being the best-studied, has become an effective method of drug delivery. In this study, we successfully synthesized mesoporous selenium (MSe) nanoparticles and first introduced them to the field of drug delivery. Loading MSe with doxorubicin (DOX) is mainly driven by the physical adsorption mechanism of the mesopores, and our results demonstrated that MSe could synergistically enhance the antitumor activity of DOX...
March 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28261763/effects-of-selenium-nanoparticles-on-reproductive-performance-of-male-sprague-dawley-rats-at-supranutritional-and-nonlethal-levels
#10
Lujie Liu, Yudan He, Zhiping Xiao, Wenjing Tao, Jia Zhu, Bin Wang, Zixun Liu, Minqi Wang
This research investigated the influence of selenium nanoparticles (SeNPs) on the reproductive performance of male Sprague-Dawley (SD) rats. A suspension of SeNPs was consecutively administered by oral gavage for 2 weeks at supranutritional (0.2, 0.4, or 0.8 mg Se/kg bw) and nonlethal (2.0, 4.0, or 8.0 mg Se/kg bw) levels to male SD rats. The normal control (NC) rats were exposed to physiological saline alone. Biochemical parameters, sperm motility, gene expression of GPx1 and GPx4, and histopathological evaluation of male spermary were measured in this work...
March 6, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28254334/selenium-nanoparticles-synthesized-in-aqueous-extract-of-allium-sativum-perturbs-the-structural-integrity-of-calf-thymus-dna-through-intercalation-and-groove-binding
#11
Preedia Babu Ezhuthupurakkal, Lokeswara Rao Polaki, Arumugam Suyavaran, Ariraman Subastri, Venugopal Sujatha, Chinnasamy Thirunavukkarasu
Biomedical application of selenium nanoparticles (SeNPs) demands the eco-friendly composite for synthesis of SeNPs. The present study reports an aqueous extract of Allium sativum (AqEAS) plug-up the current need. Modern spectroscopic, microscopic and gravimetric techniques were employed to characterize the synthesized nanoparticles. Characterization studies revealed the formation of crystalline spherical shaped SeNPs. FTIR spectrum brings out the presence of different functional groups in AqEAS, which influence the SeNPs formation and stabilization...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28241671/the-effect-of-copper-and-selenium-nanocarboxylates-on-biomass-accumulation-and-photosynthetic-energy-transduction-efficiency-of-the-green-algae-chlorella-vulgaris
#12
Natalia F Mykhaylenko, Elena K Zolotareva
Nanoaquachelates, the nanoparticles with the molecules of water and/or carboxylic acids as ligands, are used in many fields of biotechnology. Ultra-pure nanocarboxylates of microelements are the materials of spatial perspective. In the present work, the effects of copper and selenium nanoaquachelates carboxylated with citric acid on biomass accumulation of the green algae Chlorella vulgaris were examined. Besides, the efficiency of the reactions of the light stage of photosynthesis was estimated by measuring chlorophyll a fluorescence...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28191840/se-ru-decorated-porous-metal-organic-framework-nanoparticles-for-the-delivery-of-pooled-sirnas-to-reversing-multidrug-resistance-in-taxol-resistant-breast-cancer-cells
#13
Qingchang Chen, Meng Xu, Wenjing Zheng, Taoyuan Xu, Hong Deng, Jie Liu
We report here a novel and personalized strategy of selenium/ruthenium nanoparticles modified metal organic frameworks MIL-101(Fe) for delivering pooled small interfering RNAs (siRNAs) to enhance therapy efficacy by silencing multidrug resistance (MDR) genes and interfere with microtubule (MT) dynamics in MCF-7/T (Taxol-resistance) cell. The existence of coordinatively unsaturated metal sites in MIL-101(Fe) can strongly interact with the electron-rich functional groups of cysteine, which can be regarded as the linkage between selenium/ruthenium nanoparticles and MIL-101(Fe)...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28187310/proteomic-analysis-of-liver-tissue-from-rainbow-trout-oncorhynchus-mykiss-under-high-rearing-density-after-administration-of-dietary-vitamin-e-and-selenium-nanoparticles
#14
Mahdi Naderi, Saeed Keyvanshokooh, Amir Parviz Salati, Alireza Ghaedi
The aim of the present study was to investigate the effects of dietary vitamin E (vit E) and selenium nanoparticles (nanoSe) on liver proteome profile of rainbow trout under high density condition. To correlate the proteome modifications with physiological aspects, growth, serum metabolites (cortisol, glucose, lactate, ALT, AST, and ALP), and liver antioxidant-related parameters (SOD, GPx, CAT, and MDA) were also examined. A total of 1275 fish (average weight of 42.6±2.3g) were stocked into 12 tanks at a density of 80kgm(-3)...
February 4, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28183650/monodisperse-selenium-substituted-hydroxyapatite-controllable-synthesis-and-biocompatibility
#15
Jianpeng Sun, Xiaoyan Zheng, Hui Li, Daidi Fan, Zhanping Song, Haixia Ma, Xiufu Hua, Junfeng Hui
Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO3(2-) (SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28120612/h2o2-depleting-and-o2-generating-selenium-nanoparticles-for-fluorescence-imaging-and-photodynamic-treatment-of-proinflammatory-activated-macrophages
#16
Kun-Ying Lu, Po-Yen Lin, Er-Yuan Chuang, Chwen-Ming Shih, Tsai-Mu Cheng, Tsung-Yao Lin, Hsing-Wen Sung, Fwu-Long Mi
Macrophages have a pivotal role in chronic inflammatory diseases (CIDs), so imaging and controlling activated macrophage is critical for detecting and reducing chronic inflammation. In this study, photodynamic selenium nanoparticles (SeNPs) with photosensitive and macrophage-targeting bilayers were developed. The first layer of the photosensitive macromolecule was composed of a conjugate of a photosensitizer (rose bengal, RB) and a thiolated chitosan (chitosan-glutathione), resulting in a plasmonic coupling-induced red shift and broadening of RB absorption bands with increased absorption intensity...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056992/antioxidant-capacities-of-the-selenium-nanoparticles-stabilized-by-chitosan
#17
Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren, Xiaojing Leng
BACKGROUNDS: Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with zero oxidation state (Se(0)) has captured our attention because of its low toxicity and excellent bioavailability. However, Se(0) is very unstable and easily changes into the inactive form. By now many efforts have been done to protect its stability. And this work was conducted to explore the antioxidant capacities of the stable Se(0) nanoparticles (SeNPs) stabilized using chitosan (CS) with different molecular weights (Mws) (CS-SeNPs)...
January 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28044397/selenium-iv-vi-reduction-and-tolerance-by-fungi-in-an-oxic-environment
#18
C E Rosenfeld, J A Kenyon, B R James, C M Santelli
Microbial processes are known to mediate selenium (Se) oxidation-reduction reactions, strongly influencing Se speciation, bioavailability, and transport throughout the environment. While these processes have commonly been studied in anaerobic bacteria, the role that aerobic fungi play in Se redox reactions could be important for Se-rich soil systems, dominated by microbial activity. We quantified fungal growth, aerobic Se(IV, VI) reduction, and Se immobilization and volatilization in the presence of six, metal-tolerant Ascomycete fungi...
May 2017: Geobiology
https://www.readbyqxmd.com/read/28011305/aerobic-and-anaerobic-biosynthesis-of-nano-selenium-for-remediation-of-mercury-contaminated-soil
#19
Xiaonan Wang, Daoyong Zhang, Xiangliang Pan, Duu-Jong Lee, Fahad A Al-Misned, M Golam Mortuza, Geoffrey Michael Gadd
Selenium (Se) nanoparticles are often synthesized by anaerobes. However, anaerobic bacteria cannot be directly applied for bioremediation of contaminated top soil which is generally aerobic. In this study, a selenite-reducing bacterium, Citrobacter freundii Y9, demonstrated high selenite reducing power and produced elemental nano-selenium nanoparticles (nano-Se(0)) under both aerobic and anaerobic conditions. The biogenic nano-Se(0) converted 45.8-57.1% and 39.1-48.6% of elemental mercury (Hg(0)) in the contaminated soil to insoluble mercuric selenide (HgSe) under anaerobic and aerobic conditions, respectively...
March 2017: Chemosphere
https://www.readbyqxmd.com/read/28008795/a-comparison-of-fate-and-toxicity-of-selenite-biogenically-and-chemically-synthesized-selenium-nanoparticles-to-zebrafish-danio-rerio-embryogenesis
#20
Joyabrata Mal, Wouter J Veneman, Y V Nancharaiah, Eric D van Hullebusch, Willie J G M Peijnenburg, Martina G Vijver, Piet N L Lens
Microbial reduction of selenium (Se) oxyanions to elemental Se is a promising technology for bioremediation and treatment of Se wastewaters. But a fraction of biogenic nano-Selenium (nano-Se(b)) formed in bioreactors remains suspended in the treated waters, thus entering the aquatic environment. The present study investigated the toxicity of nano-Se(b) formed by anaerobic granular sludge biofilms on zebrafish embryos in comparison with selenite and chemogenic nano-Se (nano-Se(c)). The nano-Se(b) formed by granular sludge biofilms showed a LC50 value of 1...
January 9, 2017: Nanotoxicology
keyword
keyword
60772
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"