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https://www.readbyqxmd.com/read/29317822/novel-functionalized-nanoparticles-for-tumor-targeting-co-delivery-of-doxorubicin-and-sirna-to-enhance-cancer-therapy
#1
Yu Xia, Tiantian Xu, Changbing Wang, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Bing Zhu
Human homeobox protein (Nanog) is highly expressed in most cancer cells and has gradually emerged as an excellent target in cancer therapy, owing to its regulation of cancer cell proliferation, metastasis and apoptosis. In this study, we prepared tumor-targeting functionalized selenium nanoparticles (RGDfC-SeNPs) to load chemotherapeutic doxorubicin (DOX) and Nanog siRNA. Herein, RGDfC peptide was used as a tumor-targeting moiety which could specifically bind to αvβ3 integrins overexpressed on various cancer cells...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29286304/natural-nanoparticles-a-particular-matter-inspired-by-nature
#2
REVIEW
Sharoon Griffin, Muhammad Irfan Masood, Muhammad Jawad Nasim, Muhammad Sarfraz, Azubuike Peter Ebokaiwe, Karl-Herbert Schäfer, Cornelia M Keck, Claus Jacob
During the last couple of decades, the rapidly advancing field of nanotechnology has produced a wide palette of nanomaterials, most of which are considered as "synthetic" and, among the wider public, are often met with a certain suspicion. Despite the technological sophistication behind many of these materials, "nano" does not always equate with "artificial". Indeed, nature itself is an excellent nanotechnologist. It provides us with a range of fine particles, from inorganic ash, soot, sulfur and mineral particles found in the air or in wells, to sulfur and selenium nanoparticles produced by many bacteria and yeasts...
December 29, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29280251/carbon-supported-nickel-selenide-hollow-nanowires-as-advanced-anode-materials-for-sodium-ion-batteries
#3
Xuming Yang, Jiaolong Zhang, Zhenguang Wang, Hongkang Wang, Chunyi Zhi, Denis Y W Yu, Andrey L Rogach
Carbon-supported nickel selenide (Ni0.85 Se/C) hollow nanowires are prepared from carbon-coated selenium nanowires via a self-templating hydrothermal method, by first dissolving selenium in the Se/C nanowires in hydrazine, allowing it to diffuse out of the carbon layer, and then reacting with nickel ions into Ni0.85 Se nanoplates on the outer surface of the carbon. Ni0.85 Se/C hollow nanowires are employed as anode materials for sodium-ion batteries, and their electrochemical performance is evaluated via the cyclic voltammetry and electrochemical impedance spectroscopy combined with ex situ X-ray photoelectron spectroscopy and X-ray diffraction measurements...
December 27, 2017: Small
https://www.readbyqxmd.com/read/29274972/antibacterial-activity-of-selenium-enriched-lactic-acid-bacteria-against-common-food-borne-pathogens-in-vitro
#4
Jingpeng Yang, Jing Wang, Kun Yang, Miaomiao Liu, Yiman Qi, Tingjing Zhang, Mingtao Fan, Xinyuan Wei
Selenium (Se) is an essential trace element for human health and animal nutrition. The aim of this study was to evaluate the inhibitory activities of Se-enriched lactic acid bacteria (LAB), Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus, against pathogenic Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, and Listeria monocytogenes in vitro. The results indicated that the accumulation amount of Se by Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus reached 12...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29250719/selenium-nanoparticles-in-poultry-feed-modify-gut-microbiota-and-increase-abundance-of-faecalibacterium-prausnitzii
#5
Sheeana Gangadoo, Ivan Dinev, James Chapman, Robert J Hughes, Thi Thu Hao Van, Robert J Moore, Dragana Stanley
The poultry industry aims to improve productivity while maintaining the health and welfare of flocks. Pathogen control has been achieved through biosecurity, vaccinations and the use of antibiotics. However, the emergence of antibiotic resistance, in animal and human pathogens, has prompted researchers and chicken growers alike to seek alternative approaches. The use of new and emerging approaches to combat pathogen activity including nanotechnology, in particular, silver nanoparticles (NPs), has been found to not only eradicate pathogenic bacteria but also include issues of toxicity and bioaccumulation effects...
December 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29220816/ftir-and-raman-spectroscopic-studies-of-selenium-nanoparticles-synthesised-by-the-bacterium-azospirillum-thiophilum
#6
Anna V Tugarova, Polina V Mamchenkova, Yulia A Dyatlova, Alexander A Kamnev
Vibrational (Fourier transform infrared (FTIR) and Raman) spectroscopic techniques can provide unique molecular-level information on the structural and compositional characteristics of complicated biological objects. Thus, their applications in microbiology and related fields are steadily increasing. In this communication, biogenic selenium nanoparticles (Se NPs) were obtained via selenite (SeO32-) reduction by the bacterium Azospirillum thiophilum (strain VKM B-2513) for the first time, using an original methodology for obtaining extracellular NPs...
November 23, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29183326/ochrobactrum-sp-mpv1-from-a-dump-of-roasted-pyrites-can-be-exploited-as-bacterial-catalyst-for-the-biogenesis-of-selenium-and-tellurium-nanoparticles
#7
Emanuele Zonaro, Elena Piacenza, Alessandro Presentato, Francesca Monti, Rossana Dell'Anna, Silvia Lampis, Giovanni Vallini
BACKGROUND: Bacteria have developed different mechanisms for the transformation of metalloid oxyanions to non-toxic chemical forms. A number of bacterial isolates so far obtained in axenic culture has shown the ability to bioreduce selenite and tellurite to the elemental state in different conditions along with the formation of nanoparticles-both inside and outside the cells-characterized by a variety of morphological features. This reductive process can be considered of major importance for two reasons: firstly, toxic and soluble (i...
November 28, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29177363/self-assembled-selenium-nanoparticles-and-their-application-in-the-rapid-diagnostic-detection-of-small-cell-lung-cancer-biomarkers
#8
Yilin Zhao, Qiufeng Sun, Xi Zhang, Jan Baeyens, Haijia Su
By coupling molecular imprinting, chitosan biosorption and TiO2 photocatalysis, selenium nanoparticles (Se NPs) were self-assembled in a controlled manner on the molecular imprinting sites of zeolite-chitosan-TiO2 microspheres. Se NPs with different sizes and areal densities were individually synthesized by controlling the rapid adsorption of molecular-imprinted nanocomposites and photocatalytic reaction of TiO2 nanoparticles. In order to improve the sensitivity and specificity of rapid diagnostic detection, Se NPs were self-assembled again into high-order and spherically stable structures with an average size of 80 nm by well-defined monomer units, after separation from zeolite-chitosan-TiO2 microspheres with a stabilizer of 0...
November 27, 2017: Soft Matter
https://www.readbyqxmd.com/read/29174512/biosynthesis-of-selenium-nanoparticles-and-nanorods-as-a-product-of-selenite-bioconversion-by-the-aerobic-bacterium-rhodococcus-aetherivorans-bcp1
#9
Alessandro Presentato, Elena Piacenza, Max Anikovskiy, Martina Cappelletti, Davide Zannoni, Raymond J Turner
The wide anthropogenic use of selenium compounds represents the major source of selenium pollution worldwide, causing environmental issues and health concerns. Microbe-based strategies for metal removal/recovery have received increasing interest thanks to the association of the microbial ability to detoxify toxic metal/metalloid polluted environments with the production of nanomaterials. This study investigates the tolerance and the bioconversion of selenite (SeO32-) by the aerobically grown Actinomycete Rhodococcus aetherivorans BCP1 in association with its ability to produce selenium nanoparticles and nanorods (SeNPs and SeNRs)...
November 21, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29167550/speeding-up-bioproduction-of-selenium-nanoparticles-by-using-vibrio-natriegens-as-microbial-factory
#10
Helga Fernández-Llamosas, Laura Castro, María Luisa Blázquez, Eduardo Díaz, Manuel Carmona
Selenium and selenium nanoparticles (SeNPs) are extensively used in biomedicine, electronics and some other industrial applications. The bioproduction of SeNPs is gaining interest as a green method to manufacture these biotechnologically relevant products. Several microorganisms have been used for the production of SeNPs either under aerobic or anaerobic conditions. Vibrio natriegens is a non-pathogenic fast-growing bacterium, easily cultured in different carbon sources and that has recently been engineered for easy genetic manipulation in the laboratory...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29164198/aptamer-modified-selenium-nanoparticles-for-dark-field-microscopy-imaging-of-nucleolin
#11
Meng Li Liu, Hong Yan Zou, Chun Mei Li, Rong Sheng Li, Cheng Zhi Huang
Selenium nanoparticles (SeNPs) with strong green scattering light serving as light scattering nanoprobes for dark-field microscopy imaging are developed for the first time. The SeNPs show good stability, excellent biocompatibility, and high light-producing power, and can precisely and specifically target cancer cells with overexpressed nucleolin (NCL) after modification with aptamers, revealing that the SeNPs can act as a good light scattering nanoprobe for bioimaging and biolabeling.
November 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29156387/biotransformation-and-detoxification-of-selenite-by-microbial-biogenesis-of-selenium-sulfur-nanoparticles
#12
M Vogel, S Fischer, A Maffert, R Hübner, A C Scheinost, C Franzen, R Steudtner
This study combines the interaction between the toxic oxyanions selenite and selenate and the plant growth promoting bacterium Azospirillum brasilense with a comprehensive characterization of the formed selenium particles. As selenium is an essential trace element, but also toxic in high concentrations, its state of occurrence in nature is of major concern. Growth of the bacterium was affected by selenite (1-5mM) only, observable as a prolonged growth lag-phase of 3days. Subsequently, selenite reduction occurred under aerobic conditions resulting in extracellularly formed insoluble Se(0) particles...
October 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29142221/biogenic-selenium-and-its-hepatoprotective-activity
#13
Baozhen Li, Dan Li, Weixin Jing, Jinhua Fan, Hans-Uwe Dahms, Shao-Chin Lee, Lan Wang
Elemental selenium nanoparticles (SeNPs) have multiple biological activities. In this study, we investigated the protective effects of biogenic SeNPs (BioSeNPs) on CCl4-induced liver damage in mice. The results showed that: (i) when compared to sodium selenite (SS), BioSeNPs has a similar tissue distribution after intragastrical administration to mice; (ii) BioSeNPs and SS showed comparable efficacy in increasing the activities of glutathione peroxidase and thioredoxin reductase in liver cell lines, mice blood and liver; (iii) pretreatment with BioSeNPs inhibiting the elevation of activities of various enzymes significantly which included aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and liver lipid peroxide (p < 0...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141577/extracellular-synthesis-of-selenium-nanoparticles-from-an-actinomycetes-streptomyces-griseoruber-and-evaluation-of-its-cytotoxicity-on-ht-29-cell-line
#14
V R Ranjitha, Ravishankar Rai Vittal
In the present study, the extracellular synthesis of Selenium nanoparticles (SeNPs) was carried out by using culture supernatant of Streptomyces griseoruber, an Actinomycetes member isolated from the soil. Bioreduction of SeNPs was confirmed by UV-Visible spectrophotometer that showed the peak at 575 nm. XRD pattern confirmed the non-crystalline or amorphous nature of the synthesised SeNPs. FTIR spectra revealed the possible functional group that is responsible for mediating the SeNPs formation. Size and distribution of the biosynthesised SeNPs were analysed by HR-TEM that showed the formation of particle size in the range of 100-250nm...
November 13, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29141151/light-responsive-nanoparticles-for-highly-efficient-cytoplasmic-delivery-of-anticancer-agents
#15
Yangyun Wang, Yibin Deng, Huanhuan Luo, Aijun Zhu, Hengte Ke, Hong Yang, Huabing Chen
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29131972/efficient-adsorption-of-selenium-iv-from-water-by-hematite-modified-magnetic-nanoparticles
#16
Zhiyao Ma, Chao Shan, Jialiang Liang, Meiping Tong
Selenium (Se) could enter the environment through different anthropogenic sources, posing potential health risk. The removal of trace Se(IV) from water by hematite coated magnetic nanoparticle (MNP@hematite) under different solution conditions was investigated through batch experiments. The adsorption capacity of Se(IV) by MNP@hematite was 25.0 mg/g.100 μg/L of Se(IV) could be rapidly decreased to below 10 μg/L by 0.1 g/L of MNP@hematite in 10 min. MNP@hematite could effectively remove Se(IV) in a wide pH range from 4 to 9...
November 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29124492/biogenesis-of-selenium-nanoparticles-using-green-chemistry
#17
REVIEW
Sara Shoeibi, Paul Mozdziak, Afsaneh Golkar-Narenji
Selenium binds some enzymes such as glutathione peroxidase and thioredoxin reductase, which may be activated in biological infections and oxidative stress. Chemical and physical methods for synthesizing nanoparticles, apart from being expensive, have their own particular risks. However, nanoparticle synthesis through green chemistry is a safe procedure that different biological sources such as bacteria, fungi, yeasts, algae and plants can be the catalyst bed for processing. Synthesis of selenium nanoparticles (SeNPs) by macro/microorganisms causes variation in morphology and shape of the particles is due to diversity of reduction enzymes in organisms...
November 9, 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/29123393/antioxidant-and-hepatoprotective-role-of-selenium-against-silver-nanoparticles
#18
Sabah Ansar, Saad M Alshehri, Manal Abudawood, Sherifa S Hamed, Tansir Ahamad
Silver nanoparticles (AgNPs) have attracted the most interest in terms of their potential biomedical and industrial applications. However, these nanoparticles have shown their toxic behavior toward environment, living tissues, and organisms. Selenium (Se), an essential trace element, is necessary for various metabolic processes, including protection against oxidative stress and immune function. The present study was undertaken to evaluate the effect of Se against AgNP-induced hepatic oxidative stress. AgNPs were synthesized and then prepared nanoparticles were characterized using various analytical techniques such as UV-visible spectroscopy, X-ray diffraction, and transmission electron microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29111042/fabrication-and-stabilization-of-biocompatible-selenium-nanoparticles-by-carboxylic-curdlans-with-various-molecular-properties
#19
Jing-Kun Yan, Wen-Yi Qiu, Yao-Yao Wang, Wen-Han Wang, Yan Yang, He-Nan Zhang
In this study, carboxylic curdlans (Cur-4, Cur-8, and Cur-24) with different molecular properties and chain conformations were used as stabilizer and capping agent to fabricate stable and water-dispersible selenium nanoparticles (SeNPs). Results showed that molecular properties and chain conformations of carboxylic curdlans remarkably influenced the size, morphology, structure, and stability of SeNPs and the carboxylic curdlan was ligated to SeNPs via OH⋯Se interaction. The as-prepared SeNPs was amorphous and showed homogeneous and monodisperse spherical structure with size of ∼50-90nm...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29110163/selenite-removal-and-reduction-by-growing-aspergillus-sp-j2
#20
Zhijian Li, Haifeng Li, Huiying Hu
In this study, the removal and reduction of selenite [Se(IV)] by growing Aspergillus sp. J2 were investigated. The lag phase, growth rate and biomass of J2 was not significantly influenced by the presence of 100 mg/L Se(IV). A rapid Se(IV) removal process took place from the 3rd to the 4th day during the growth of J2. Scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and X-ray diffraction analyses showed that the Se(IV) did not cause any visible effects on cell morphology and the reduced amorphous elemental selenium [Se(0)] nanoparticles were mainly on the surface of the mycelial cell walls...
November 6, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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