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selenium nanoparticle

Humberto H Lara, Gregory Guisbiers, Jonathan Mendoza, Lawrence C Mimun, Brandy A Vincent, Jose L Lopez-Ribot, Kelly L Nash
Background: Candida albicans is a major opportunistic fungal pathogen. One of the most important virulence factors that contribute to the pathogenesis of candidiasis is its ability to form biofilms. A key characteristic of Candida biofilms is their resistance to antifungal agents. Due to significant morbidity and mortality rates related to biofilm-associated drug resistance, there is an urgency to develop novel nanotechnology-based approaches preventing biofilm-related infections. Methods: In this study, we report, for the first time, the synthesis of selenium nanoparticles by irradiating selenium pellets by nanosecond pulsed laser ablation in liquid chitosan as a capping agent...
2018: International Journal of Nanomedicine
Ahmed A Abd-Rabou, Aziza B Shalby, Hanaa H Ahmed
Drug resistance is a major challenge of breast and colon cancer therapies leading to treatment failure. The main objective of the current study is to investigate whether selenium nanoparticles (nano-Se) can induce the chemo-sensitivity of 5-fluorouracil (FU)-encapsulated poly (D, L-lactide-co-glycolide) nanoparticles (nano-FU) in breast and colon cancer cell lines. Nano-Se and nano-FU were synthesized and characterized, then applied individually or in combination upon MCF7, MDA-MB-231, HCT 116, and Caco-2 cancerous cell lines...
May 11, 2018: Biological Trace Element Research
Meera Surendran Nair, Abhinav Upadhyay, Samantha Fancher, Indu Upadhyaya, Swayandipta Dey, Anup Kollanoor-Johny, Jing Zhao, Kumar Venkitanarayanan
The present study investigated the efficacy of selenium (Se) in reduction of enterohemorrhagic Escherichia coli (EHEC) exopolysaccharide (EPS) synthesis, inhibition of biofilm formation at 25 and 4°C on polystyrene surface, and inactivation of mature EHEC biofilms in combination with hot water. Sterile 96-well polystyrene plates inoculated with EHEC (∼6.0 log CFU per well) were treated with a subinhibitory concentration (SIC) of Se, and biofilms were allowed to mature at 4 and 25°C for 96 h. Biofilm-associated bacterial population was determined by scraping and plating, whereas the extent of EPS production was determined using ruthenium red staining assay...
May 10, 2018: Journal of Food Protection
Moosa Javdani, Atefeh Habibi, Sadegh Shirian, Gholam Ali Kojouri, Farzaneh Hosseini
Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal groups as experimental and control. Under general inhalation anesthesia, in both groups, SCI was created, at the T9-10 level of the column. On the third day after the operation, a supplement of selenium nanoparticle was administered to the experimental group at 0...
May 5, 2018: Biological Trace Element Research
Jun Wu, Raymond J Zeng
Iron sulfide (FeS) nanoparticles have been applied for selenite remediation in recent decades. However, the easy aggregation and oxidization of FeS nanoparticles hamper their reactivity during the process of pollutant removal. In this study, in situ immobilization technology was applied to prepare FeS nanoparticles-impregnated alginate composite (FeS-SA) beads for successful selenite remediation. Almost 100% of the selenite (0.13 mM) was removed by FeS-SA beads, whereas only 27% of the selenite was eliminated by pure non-stabilized FeS suspension and sodium alginate (SA) beads...
May 3, 2018: Environmental Science & Technology
Bo Hu, Ranran Cheng, Xiaonan Gao, Xiaohong Pan, Fanpeng Kong, Xiaojun Liu, Kehua Xu, Bo Tang
Hydrogen selenide (H2Se), as a highly-active reductant, is believed as a key molecule in the cytotoxicity of inorganic selenium compounds. However, the detail mechanism has hardly been studied, since the distribution of H2Se in the subcellular organelles remains unclear. Herein, we exploited a series of novel targetable mesoporous silica nanoplatforms to map the distribution of H2Se in cytoplasm, lysosome and mitochondria of cancer cells. The subcellular targeting moiety conjugated mesoporous silica nanoparticles (MSNs) were assembled with a small-molecule fluorescent probe (NIR-H2Se) for imaging endogenous H2Se in the corresponding organelles...
April 30, 2018: ACS Applied Materials & Interfaces
Nasrin Parsameher, Sassan Rezaei, Sadegh Khodavasiy, Samira Salari, Sanaz Hadizade, Mohammad Kord, Seyed Amin Ayatollahi Mousavi
Background and Purpose: Candida albicans is the most common Candida species (sp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed the antifungal effects of biogenic selenium nanoparticles on C. albicans and determined the expression of ERG11 and CDR1 genes...
September 2017: Advances in Medical Mycology (Iran)
Neeraj Kumar, K K Krishnani, Sanjay Kumar Gupta, Rupam Sharma, Raju Baitha, Dilip Kumar Singh, Narendra Pratap Singh
An environment friendly and sustainable approach is being emerged in the area of nanotechnology for accelerated growth and development of culturable aquatic animals hence green chemistry is gaining momentum in recent years. The present study has been carried out to delineate the effects of selenium nanoparticles (Se-NPs) on growth performance, antioxidative status and immunity of fish reared under lead (Pb) and high temperature (34 °C). Three hundred and sixty five fish were equally distributed in seven treatments in triplicates...
April 24, 2018: Fish & Shellfish Immunology
Ahmad Reza Shahverdi, Faranak Shahverdi, Elnaz Faghfuri, Mohammad Reza Khoshayand, Faranak Mavandadnejad, Mohammad Hossein Yazdi, Mohsen Amini
BACKGROUNDS AND AIMS: Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in vitro and in vivo effects of SeNPs and folic acid surface-coated selenium nanoparticles (FA@SeNPs) on breast cancer. METHODS: FA@SeNPs and SeNPs were chemically synthesized and characterized with different instrumental techniques. The cytotoxicity of both nanomaterials was evaluated against 4T1 cells...
April 23, 2018: Archives of Medical Research
Cheng-Kuan Su, Wei-Cheng Chen
To extend the applicability of solid phase extraction devices manufactured using 3D printing technologies, a stereolithographic 3D printer and resins incorporating titanium dioxide nanoparticles (TiO2 NPs) were employed to fabricate a demountable minicolumn with TiO2 NP-incorporated packing as a sample pretreatment device for the selective extraction of inorganic As and Se species from high-salt-content samples, and to facilitate their analyses when coupled to an inductively coupled plasma mass spectrometer...
April 25, 2018: Mikrochimica Acta
Bozena Hosnedlova, Marta Kepinska, Sylvie Skalickova, Carlos Fernandez, Branislav Ruttkay-Nedecky, Qiuming Peng, Mojmir Baron, Magdalena Melcova, Radka Opatrilova, Jarmila Zidkova, Geir Bjørklund, Jiri Sochor, Rene Kizek
Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms...
2018: International Journal of Nanomedicine
Anna Baranik, Anna Gagor, Ignasi Queralt, Eva Marguí, Rafal Sitko, Beata Zawisza
A nanocomposite prepared from graphene nanosheets and cerium nanoparticles (G/CeO2 ) was applied to the extraction of Se(IV), As(V), As(III), Cu(II) and Pb(II). The structure of G/CeO2 was investigated by scanning electron microscopy, X-ray diffraction and Raman spectroscopy. The optimal pH values for extraction are 4.0 for As(V), 3.0 for Se(IV), and 6.0 for both Cu(II) and Pb(II). The maximum adsorption capacity of G/CeO2 (expressed as mg·g-1 ) were calculated by the Langmuir model and are found to be 8.4 for As(V), 14...
April 23, 2018: Mikrochimica Acta
Hebatallah Husseini Atteia, Manar Hamed Arafa, Kousalya Prabahar
Selenium nanoparticles (Se-NPs) are customizable drug delivery vehicles that show good bioavailability, higher efficacy and lower toxicity than ordinary Se. Pre-treatment of male rats with these NPs has been recently shown to exert a protective effect against chromium-induced thyroid dysfunction. This study, therefore, aimed to investigate and characterize the potential protective mechanism of Se-NPs against lead (Pb) acetate-induced thyrotoxicity. We found that prophylactic and concurrent treatment of Pb acetate-exposed rats with Nano-Se (0...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Halla Laufey Hauksdóttir, Thomas J Webster
Iron oxide nanoparticles (IONP) are already well-established in the medical field due to their ability to improve contrast in magnetic resonance imaging (MRI) and for their external magnetic control in the body. Moreover, selenium has been shown to kill numerous cancer cells at lower concentrations that IONP (e.g., 1 μg/ml). Selenium is a trace mineral of growing interest in cancer treatment since it is an essential nutrient in the human body and can interfere with thiolcontaining proteins necessary for cancer cells to function...
March 1, 2018: Journal of Biomedical Nanotechnology
Yinghua Li, Zhengfang Lin, Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu
Introduction: As a therapeutic antiviral agent, the clinical application of amantadine (AM) is limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses and meet the growing demand of clinical diagnosis, the use of biological nanoparticles (NPs) has increased in order to develop novel anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity and excellent activities has attracted increasing attention for biomedical intervention in recent years...
2018: International Journal of Nanomedicine
Abdulsalam A Alkhudhayri, Mohamed A Dkhil, Saleh Al-Quraishy
Background: Although elemental selenium has been found to be effective against Eimeria , no study has yet investigated the effects of selenium nanoparticles (SeNPs) on the Eimeria parasite. The aim of this study, therefore, was to evaluate the ameliorative effect of SeNPs compared with elemental selenium on mice jejunum infected with sporulated oocysts of Eimeria papillata . Methods: The mice were divided into 4 groups, with the first being the non-infected, control group, and the second, third, and fourth groups being orally inoculated with 1,000 sporulated oocysts of E...
2018: International Journal of Nanomedicine
Xian Xia, Zijie Zhou, Shijuan Wu, Dan Wang, Shixue Zheng, Gejiao Wang
Selenite reductase CsrF overexpressed Escherichia coli was used as a microbial factory to produce Se(0) nanoparticles (Bio-SeNPs). The Bio-SeNPs were characterized by transmission electronic microscopy, element mapping, scanning electron microscopy, energy-dispersive X-ray spectrographs, Zeta-potential, dynamic light scattering, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses. The results indicated that Bio-SeNPs are irregular spheres with diameters from 60 to105 nm and mainly consist of Se(0), proteins and lipids...
April 12, 2018: Nanomaterials
Yuntao Liu, Siqi Zeng, Yixi Liu, Wenjuan Wu, Yingbin Shen, Lan Zhang, Cheng Li, Hong Chen, Aiping Liu, Li Shen, Bin Hu, Caixia Wang
Selenium nanoparticles (SeNPs) were prepared by adding Catathelasma ventricosum polysaccharides (CVPs) to the redox system of selenite and ascorbic acid. Taking particle size as an investigation index, the optimal synthesis conditions of CVPs-SeNPs were obtained by orthogonal test. Herein, the diameter, morphology, and stability of the CVPs-SeNPs were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the antidiabetic activities of CVPs-SeNPs were evaluated by STZ (streptozocin)-induced diabetic mice...
March 27, 2018: International Journal of Biological Macromolecules
Hossein Kalantari, Mahboobeh Manoochehri
A metal-organic framework nanocomposite was synthesized and applied to speciation analysis of Se(IV) and Se(VI). The sorbent is composed of MIL-101(Cr) and magnetite nanoparticles modified with dithiocarbamate. It is capably of selectively extracting Se(IV) at pH = 1.85, while Se(VI) remains in solution. The total amount of selenium can then be determined by reducing Se(VI) to Se(IV) and also extracting it. The extraction parameters were optimized by employing design-of-experiments methodology. Selenium was then quantified by electrothermal AAS...
February 26, 2018: Mikrochimica Acta
Yu Xia, Min Guo, Tiantian Xu, Yinghua Li, Changbing Wang, Zhengfang Lin, Mingqi Zhao, Bing Zhu
Background: Small interfering RNA (siRNA) as a new therapeutic modality holds promise for cancer treatment. However, the traditional viral carriers are prone to immunogenicity and risk of insertional mutagenesis. Methods: In order to provide a tumor-targeted delivery carrier of siRNA in cancer therapy, the hyaluronic acid (HA)-selenium (Se)-polyethylenimine (PEI) nanoparticle (NP) was fabricated by decorating SeNP with HA as a tumor-targeting moiety and by linking the polycationic polymers polyethylenimine PEI onto the surface of SeNP...
2018: International Journal of Nanomedicine
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