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https://www.readbyqxmd.com/read/29754588/evaluating-seroprevalence-to-circumsporozoite-protein-to-estimate-exposure-to-three-species-of-plasmodium-in-the-brazilian-amazon
#1
Virginia Araujo Pereira, Juan Camilo Sánchez-Arcila, Mariana Pinheiro Alves Vasconcelos, Amanda Ribeiro Ferreira, Lorene de Souza Videira, Antonio Teva, Daiana Perce-da-Silva, Maria Teresa Queiroz Marques, Luzia Helena de Carvalho, Dalma Maria Banic, Luiz Cristóvão Sobrino Pôrto, Joseli Oliveira-Ferreira
BACKGROUND: Brazil has seen a great decline in malaria and the country is moving towards elimination. However, for eventual elimination, the control program needs efficient tools in order to monitor malaria exposure and transmission. In this study, we aimed to evaluate whether seroprevalence to the circumsporozoite protein (CSP) is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian Amazon. METHODS: Cross-sectional surveys were conducted in a rural area of Porto Velho, Rondônia state...
May 14, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29739839/transcriptional-induction-of-cell-wall-remodelling-genes-is-coupled-to-microtubule-driven-growth-isotropy-at-the-shoot-apex-in-arabidopsis
#2
Alessia Armezzani, Ursula Abad, Olivier Ali, Amélie Andres Robin, Laetitia Vachez, Antoine Larrieu, Ewa J Mellerowicz, Ludivine Taconnat, Virginie Battu, Thomas Stanislas, Mengying Liu, Teva Vernoux, Jan Traas, Massimiliano Sassi
The shoot apical meristem of higher plants continuously generates new tissues and organs through complex changes in growth rates and directions of its individual cells. Cell growth, driven by turgor pressure, largely depends on the cell walls, which allow cell expansion through synthesis and structural changes. A previous study revealed a major contribution of wall isotropy in organ emergence, through the disorganization of cortical microtubules. We show here that this disorganization is coupled with the transcriptional control of genes involved in wall remodelling...
May 8, 2018: Development
https://www.readbyqxmd.com/read/29728521/financial-relationships-between-neurologists-and-industry-the-2015-open-payments-database
#3
Aditi Ahlawat, Pushpa Narayanaswami
OBJECTIVE: To analyze research and nonresearch payments from the pharmaceutical and device industry to neurologists in 2015 using the Centers for Medicare and Medicaid Services (CMS) Open Payments database. METHODS: In this retrospective database analysis, we computed the percentage of neurologists in the United States receiving payments, the median/mean payments per neurologist, payment categories, regional trends, and sponsors. We computed the number of practicing neurologists from the Association of American Medical Colleges State Physician Workforce data book, 2015...
May 4, 2018: Neurology
https://www.readbyqxmd.com/read/29720582/author-correction-a-mechanistic-framework-for-auxin-dependent-arabidopsis-root-hair-elongation-to-low-external-phosphate
#4
Rahul Bhosale, Jitender Giri, Bipin K Pandey, Ricardo F H Giehl, Anja Hartmann, Richard Traini, Jekaterina Truskina, Nicola Leftley, Meredith Hanlon, Kamal Swarup, Afaf Rashed, Ute Voß, Jose Alonso, Anna Stepanova, Jeonga Yun, Karin Ljung, Kathleen M Brown, Jonathan P Lynch, Liam Dolan, Teva Vernoux, Anthony Bishopp, Darren Wells, Nicolaus von Wirén, Malcolm J Bennett, Ranjan Swarup
The original version of this Article omitted the following from the Acknowledgements: 'We also thank DBT-CREST BT/HRD/03/01/2002.' This has been corrected in both the PDF and HTML versions of the Article.
May 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29713014/the-rosa-genome-provides-new-insights-into-the-domestication-of-modern-roses
#5
Olivier Raymond, Jérôme Gouzy, Jérémy Just, Hélène Badouin, Marion Verdenaud, Arnaud Lemainque, Philippe Vergne, Sandrine Moja, Nathalie Choisne, Caroline Pont, Sébastien Carrère, Jean-Claude Caissard, Arnaud Couloux, Ludovic Cottret, Jean-Marc Aury, Judit Szécsi, David Latrasse, Mohammed-Amin Madoui, Léa François, Xiaopeng Fu, Shu-Hua Yang, Annick Dubois, Florence Piola, Antoine Larrieu, Magali Perez, Karine Labadie, Lauriane Perrier, Benjamin Govetto, Yoan Labrousse, Priscilla Villand, Claudia Bardoux, Véronique Boltz, Céline Lopez-Roques, Pascal Heitzler, Teva Vernoux, Michiel Vandenbussche, Hadi Quesneville, Adnane Boualem, Abdelhafid Bendahmane, Chang Liu, Manuel Le Bris, Jérôme Salse, Sylvie Baudino, Moussa Benhamed, Patrick Wincker, Mohammed Bendahmane
Roses have high cultural and economic importance as ornamental plants and in the perfume industry. We report the rose whole-genome sequencing and assembly and resequencing of major genotypes that contributed to rose domestication. We generated a homozygous genotype from a heterozygous diploid modern rose progenitor, Rosa chinensis 'Old Blush'. Using single-molecule real-time sequencing and a meta-assembly approach, we obtained one of the most comprehensive plant genomes to date. Diversity analyses highlighted the mosaic origin of 'La France', one of the first hybrids combining the growth vigor of European species and the recurrent blooming of Chinese species...
April 30, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29681174/-the-patients-cost-of-the-montelukast-therapy-due-to-the-generic-substitution
#6
Balázs Répásy, Dóra Endrei, Antal Zemplényi, István Ágoston, Imre Boncz
INTRODUCTION AND AIM: The aim of our study was to analyse the public price of the montelukast sodium therapy in Hungary. METHOD: Data derived from the nationwide pharmaceutical database of the Hungarian National Health Insurance Fund Administration. We observed the turnover and price of the medicaments containing the active substance montelukast sodium from 2007 to 2015. Accordingly, our indicators were: consumer price, DCT (daily cost of therapy), co-payment, quasi co-payment, DOT (days of treatment)...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29674079/a-comparison-study-on-the-use-of-dowex-1-and-teva-resin-in-determination-of-99-tc-in-environmental-and-nuclear-coolant-samples-in-a-sia-system-with-icp-ms-detection
#7
Kamila Kołacińska, Zbigniew Samczyński, Jakub Dudek, Anna Bojanowska-Czajka, Marek Trojanowicz
This work refers to a comparative study of sorbents widely used in determinations of 99 Tc such as TEVA resin and Dowex 1. Despite having a similar functional group of quaternary amines, both materials represent different chromatographic methods-extraction (TEVA resin) and anion exchange (Dowex 1)-which provides a diverse range of their properties significant in determination of 99 Tc in flow conditions. The comparative tests, carried out in a SIA-LOV (Sequential Injection Analysis-Lab-on-Valve) system combined with mass spectrometric (ICP-MS) detection, considered several factors that are crucial from the standpoint of resin´s utility such as sorption capacity, durability, or selectivity, critical in 99 Tc separation from interferences...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29652613/knowledge-and-concern-about-stis-hiv-and-sociodemographic-variables-associated-with-getting-tested-for-hiv-among-the-general-population-in-spain
#8
Inmaculada Teva, Ludgleydson Fernandes de Araújo, María de la Paz Bermúdez
HIV testing is important in terms of prevention and treatment. However, HIV testing rates in the Spanish general population remains low. Therefore, HIV testing promotion constitutes a key issue. A high level of knowledge about HIV/AIDS is associated with having been tested for HIV. The general aim of this study was to determine the prevalence of people who had ever been tested for HIV in Spain. The sample consisted of 1,106 participants from the general population - 60.0% females and 40.0% males - aged between 17 and 55 years old...
April 13, 2018: Journal of Psychology
https://www.readbyqxmd.com/read/29651114/a-mechanistic-framework-for-auxin-dependent-arabidopsis-root-hair-elongation-to-low-external-phosphate
#9
Rahul Bhosale, Jitender Giri, Bipin K Pandey, Ricardo F H Giehl, Anja Hartmann, Richard Traini, Jekaterina Truskina, Nicola Leftley, Meredith Hanlon, Kamal Swarup, Afaf Rashed, Ute Voß, Jose Alonso, Anna Stepanova, Jeonga Yun, Karin Ljung, Kathleen M Brown, Jonathan P Lynch, Liam Dolan, Teva Vernoux, Anthony Bishopp, Darren Wells, Nicolaus von Wirén, Malcolm J Bennett, Ranjan Swarup
Phosphate (P) is an essential macronutrient for plant growth. Roots employ adaptive mechanisms to forage for P in soil. Root hair elongation is particularly important since P is immobile. Here we report that auxin plays a critical role promoting root hair growth in Arabidopsis in response to low external P. Mutants disrupting auxin synthesis (taa1) and transport (aux1) attenuate the low P root hair response. Conversely, targeting AUX1 expression in lateral root cap and epidermal cells rescues this low P response in aux1...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29582406/reslizumab-for-treating-asthma-with-elevated-blood-eosinophils-inadequately-controlled-by-inhaled-corticosteroids-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#10
REVIEW
Keith Cooper, Geoff Frampton, Petra Harris, Micah Rose, Maria Chorozoglou, Karen Pickett
As part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) process, the manufacturer of reslizumab (Teva) submitted evidence for its clinical and cost effectiveness for the treatment of eosinophilic asthma inadequately controlled by inhaled corticosteroids. NICE commissioned Southampton Health Technology Assessments Centre (SHTAC) as an independent Evidence Review Group (ERG) to provide a critique of the manufacturer's submitted evidence. Reslizumab is compared with best standard of care and omalizumab, for a small 'overlap' population of patients who have both eosinophilic and IgE-mediated severe asthma...
May 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29507538/pregnancy-outcomes-from-the-branded-glatiramer-acetate-pregnancy-database
#11
Magnhild Sandberg-Wollheim, Orit Neudorfer, Augusto Grinspan, Bianca Weinstock-Guttman, Judith Haas, Guillermo Izquierdo, Claire Riley, Amy Perrin Ross, Peleg Baruch, Talya Drillman, Patricia K Coyle
Background: Appropriate counseling and treatment for women with multiple sclerosis (MS) who may become pregnant requires an understanding of the effects of exposure to disease-modifying therapies (DMTs) during pregnancy. Current reports and studies are limited in their usefulness, mostly by small sample size. Branded glatiramer acetate (GA) is a DMT approved for the treatment of relapsing forms of MS. For more than 2 decades, it has been shown to be efficacious and to have a favorable safety profile...
January 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29451078/oncologists-perceptions-of-drug-affordability-using-nccn-evidence-blocks-results-from-a-national-survey
#12
Bijal Shah-Manek, William Wong, Arliene Ravelo, Marco DiBonaventura
BACKGROUND: The increasing prevalence of cancer coupled with approvals of new drugs and technologies used in therapy have brought increased scrutiny to the cost and value of treatments in oncology. To address the rising concern about oncology drug costs, several organizations have developed value frameworks to help assess the value of oncology regimens. The objective of this study was to assess oncologists' perceptions, awareness, and knowledge of all oncology value frameworks in the United States and to understand oncologists' perceptions of affordability in the context of National Comprehensive Cancer Network (NCCN) Evidence Blocks...
February 16, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29448060/a-rapid-method-for-the-sequential-separation-of-polonium-plutonium-americium-and-uranium-in-drinking-water
#13
B Lemons, H Khaing, A Ward, P Thakur
A new sequential separation method for the determination of polonium and actinides (Pu, Am and U) in drinking water samples has been developed that can be used for emergency response or routine water analyses. For the first time, the application of TEVA chromatography column in the sequential separation of polonium and plutonium has been studied. This method utilizes a rapid Fe+3 co-precipitation step to remove matrix interferences, followed by plutonium oxidation state adjustment to Pu4+ and an incubation period of ~ 1 h at 50-60 °C to allow Po2+ to oxidize to Po4+ ...
June 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29382952/establishing-rapid-analysis-of-pu-isotopes-in-seawater-to-study-the-impact-of-fukushima-nuclear-accident-in-the-northwest-pacific
#14
Wu Men, Jian Zheng, Hai Wang, Youyi Ni, Tatsuo Aono, Sherrod L Maxwell, Keiko Tagami, Shigeo Uchida, Masatoshi Yamada
In order to assess the impact of the Fukushima derived Pu isotopes on seawater, a new analytical method to rapidly determine Pu isotopes in seawater by SF-ICP-MS including Fe(OH)2 primary co-precipitation, CaF2 /LaF3 secondary co-precipitation and TEVA+UTEVA+DGA extraction chromatographic separation was established. High concentration efficiency (~100%) and high U decontamination factor (~107 ) were achieved. The plutonium chemical recoveries were 74-88% with the mean of 83 ± 5%. The precisions for both 240 Pu/239 Pu atom ratios and 239+240 Pu activity concentrations were less than 5% when 15 L of seawater samples with the typical 239+240 Pu activity of the Northwest Pacific were measured...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29364929/real-life-effectiveness-and-safety-of-salbutamol-steri-neb%C3%A2-vs-ventolin-nebules%C3%A2-for-exacerbations-in-patients-with-copd-historical-cohort-study
#15
COMPARATIVE STUDY
David B Price, Eran Gefen, Gokul Gopalan, Rosie McDonald, Vicky Thomas, Simon Wan Yau Ming, Emily Davis
INTRODUCTION: Ventolin Nebules® (reference product; GlaxoSmithKline) was the first licensed nebulizer solution containing the rapid-onset, short-acting β2-agonist salbutamol. Salbutamol Steri-Neb™ (comparator; Teva Pharmaceuticals, Inc.) has the same chemical composition as the reference product. This study evaluated whether the effectiveness of the comparator is non-inferior to the reference product alongside concomitant medications during real-life clinical management of COPD exacerbations...
2018: PloS One
https://www.readbyqxmd.com/read/29171818/fremanezumab-for-the-preventive-treatment-of-chronic-migraine
#16
RANDOMIZED CONTROLLED TRIAL
Stephen D Silberstein, David W Dodick, Marcelo E Bigal, Paul P Yeung, Peter J Goadsby, Tricia Blankenbiller, Melissa Grozinski-Wolff, Ronghua Yang, Yuju Ma, Ernesto Aycardi
BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine. We compared two fremanezumab dose regimens with placebo for the prevention of chronic migraine. METHODS: In this phase 3 trial, we randomly assigned patients with chronic migraine (defined as headache of any duration or severity on ≥15 days per month and migraine on ≥8 days per month) in a 1:1:1 ratio to receive fremanezumab quarterly (a single dose of 675 mg at baseline and placebo at weeks 4 and 8), fremanezumab monthly (675 mg at baseline and 225 mg at weeks 4 and 8), or matching placebo...
November 30, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29163985/response-to-inhaled-loxapine-in-patients-with-schizophrenia-or-bipolar-i-disorder-panss-ec-responder-analyses
#17
Scott Zeller, Leslie Zun, James V Cassella, Daniel A Spyker, Paul P Yeung
Background: Efficacy of inhaled loxapine 5 or 10 mg in treating agitation was shown using the Positive and Negative Syndrome Scale - Excited Component (PANSS-EC) in two Phase III randomised, double-blind, placebo-controlled trials in 344 agitated patients with schizophrenia and 314 patients with bipolar I disorder (Clinicaltrials.gov: NCT00628589, NCT00721955). Aims: To examine the five individual items comprising the PANSS-EC and the percentage of patients achieving a clinical response (reduction of ≥40%) in PANSS-EC (Response-40) for these two studies...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29136813/isolation-of-236-u-and-239-240-pu-from-seawater-samples-and-its-determination-by-accelerator-mass-spectrometry
#18
Mercedes López-Lora, Elena Chamizo, María Villa-Alfageme, Santiago Hurtado-Bermúdez, Núria Casacuberta, Manuel García-León
In this work we present and evaluate a radiochemical procedure optimised for the analysis of236 U and239,240 Pu in seawater samples by Accelerator Mass Spectrometry (AMS). The method is based on Fe(OH)3 co-precipitation of actinides and uses TEVA® and UTEVA® extraction chromatography resins in a simplified way for the final U and Pu purification. In order to improve the performance of the method, the radiochemical yields are analysed in 1 to 10L seawater volumes using alpha spectrometry (AS) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29108938/fractional-exhaled-nitric-oxide-as-a-predictor-of-response-to-inhaled-corticosteroids-in-patients-with-non-specific-respiratory-symptoms-and-insignificant-bronchodilator-reversibility-a-randomised-controlled-trial
#19
David B Price, Roland Buhl, Adrian Chan, Daryl Freeman, Elizabeth Gardener, Clifford Godley, Kevin Gruffydd-Jones, Lorcan McGarvey, Ken Ohta, Dermot Ryan, Jörgen Syk, Ngiap Chuan Tan, TzeLee Tan, Mike Thomas, Sen Yang, Priyanka Raju Konduru, Marcus Ngantcha, Martina Stagno d'Alcontres, Therese S Lapperre
BACKGROUND: Chronic non-specific respiratory symptoms are difficult to manage. This trial aimed to evaluate the association between baseline fractional exhaled nitric oxide (FeNO) and the response to inhaled corticosteroids in patients with non-specific respiratory symptoms. METHODS: In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged 18-80 years, with cough, wheeze, or dyspnoea and less than 20% bronchodilator reversibility across 26 primary care centres and hospitals in the UK and Singapore...
January 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29083975/factors-associated-with-direct-health-care-costs-among-patients-with-migraine
#20
Machaon Bonafede, Qian Cai, Katherine Cappell, Gilwan Kim, Sandhya J Sapra, Neel Shah, Katherine Widnell, Paul Winner, Pooja Desai
BACKGROUND: Migraine imposes substantial economic burden on patients and the health care system. Approximately 18% of women and 6% of men suffer from migraine in the United States. This is a heterogeneous group, and little data are available to evaluate factors associated with migraine costs. OBJECTIVE: To evaluate characteristics associated with high costs among commercially insured patients with migraine. METHODS: This retrospective analysis identified patients with migraine in the Truven Health MarketScan Research Databases between January 2008 and June 2013...
November 2017: Journal of Managed Care & Specialty Pharmacy
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