keyword
https://read.qxmd.com/read/38500057/investigating-the-causal-relationship-between-immune-cell-and-alzheimer-s-disease-a-mendelian-randomization-analysis
#21
JOURNAL ARTICLE
Min Shen, Linlin Zhang, Chen Chen, Xiaocen Wei, Yuning Ma, Yuxia Ma
BACKGROUND: Complex interactions between the immune system and the brain may affect neural development, survival, and function, with etiological and therapeutic implications for neurodegenerative diseases. However, previous studies investigating the association between immune inflammation and Alzheimer's disease (AD) have yielded inconsistent results. METHODS: We applied Mendelian randomization (MR) to examine the causal relationship between immune cell traits and AD risk using genetic variants as instrumental variables...
March 18, 2024: BMC Neurology
https://read.qxmd.com/read/38499577/multichannel-bridges-and-nsc-synergize-to-enhance-axon-regeneration-myelination-synaptic-reconnection-and-recovery-after-sci
#22
JOURNAL ARTICLE
Usha Nekanti, Pooja S Sakthivel, Atena Zahedi, Dana A Creasman, Rebecca A Nishi, Courtney M Dumont, Katja M Piltti, Glenn L Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian T David, Zhiling Guo, Stephanie K Seidlits, Xiangmin Xu, Lonnie D Shea, Brian J Cummings, Aileen J Anderson
Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a permissive environment for rapid cellularization and robust axonal regrowth through this otherwise inhibitory milieu. However, without additional intervention, regenerated axons remain largely unmyelinated (<10%), limiting functional repair. While transplanted human neural stem cells (hNSC) myelinate axons after spinal cord injury (SCI), hNSC fate is highly influenced by the SCI inflammatory microenvironment, also limiting functional repair...
March 18, 2024: NPJ Regenerative Medicine
https://read.qxmd.com/read/38496551/meditation-experience-is-associated-with-increased-structural-integrity-of-the-pineal-gland-and-greater-total-grey-matter-maintenance
#23
Emanuele Rg Plini, Michael C Melnychuk, Paul M Dockree
Growing evidence demonstrates that meditation practice supports cognitive functions including attention and interoceptive processing, and is associated with structural changes across cortical networks including prefrontal regions, and the insula. However, the extent of subcortical morphometric changes linked to meditation practice is less appreciated. A noteworthy candidate is the Pineal Gland, a key producer of melatonin, which regulates circadian rhythms that augment sleep-wake patterns, and may also provide neuroprotective benefits to offset cognitive decline...
March 5, 2024: medRxiv
https://read.qxmd.com/read/38496406/a-randomized-proof-of-mechanism-trial-of-tnf-antagonism-for-motivational-anhedonia-and-related-corticostriatal-circuitry-in-depressed-patients-with-high-inflammation
#24
Michael Treadway, Sarah Etuk, Jessica Cooper, Shabnam Hossein, Emma Hahn, Samantha Betters, Shiyin Liu, Amanda Arulpragasam, Brittany DeVries, Nadia Irfan, Makiah Nuutinen, Evanthia Wommack, Bobbi Woolwine, Mandakh Bekhbat, Philip Kragel, Jennifer Felger, Ebrahim Haroon, Andrew Miller
Chronic, low-grade inflammation has been associated with motivational deficits in patients with major depression (MD). In turn, impaired motivation has been linked to poor quality of life across psychiatric disorders. We thus determined effects of the anti-inflammatory drug infliximab-a potent tumor necrosis factor (TNF) antagonist-on behavioral and neural measures of motivation in 42 medically stable, unmedicated MD patients with a C-reactive protein > 3mg/L. All patients underwent a double-blind, placebo-controlled, single-dose, randomized clinical trial with infliximab (5mg/kg) versus placebo...
March 5, 2024: Research Square
https://read.qxmd.com/read/38491727/adding-to-the-neuroimmune-network-model-a-commentary-on-nusslock-et%C3%A2-al-2024
#25
JOURNAL ARTICLE
Aaron S Heller
Work by many groups demonstrate links between peripheral markers of inflammation and symptoms of depression. Here, Nusslock and colleagues present an update to their neuroimmune network model to incorporate a developmental lens. They propose that specific neural circuits may be responsible for causing heightened inflammation. One principal circuit includes the amygdala and prefrontal cortex and is proposed to be involved in threat detection. Thus, heightened threat sensitivity resulting from early life stress is suggested to cause increases in inflammatory signaling...
March 15, 2024: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://read.qxmd.com/read/38488981/influenza-a-virus-pb1-f2-induces-affective-disorder-by-interfering-synaptic-plasticity-in-hippocampal-dentate-gyrus
#26
JOURNAL ARTICLE
Saiying Wang, Haijun Zhang, Rui Liu, Peijun Han, Qi Yang, Caiyan Cheng, Yue Chen, Zheng Rong, Chang Su, Fei Li, Gaofei Wei, Minggao Zhao, Le Yang
Influenza A virus (IAV) infection, which leads to millions of new cases annually, affects many tissues and organs of the human body, including the central nervous system (CNS). The incidence of affective disorders has increased after the flu pandemic; however, the potential mechanism has not been elucidated. PB1-F2, a key virulence molecule of various influenza virus strains, has been shown to inhibit cell proliferation and induce host inflammation; however, its role in the CNS has not been studied. In this study, we constructed and injected PB1-F2 into the hippocampal dentate gyrus (DG), a region closely associated with newborn neurons and neural development, to evaluate its influence on negative affective behaviors and learning performance in mice...
March 15, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38488630/stress-in-the-microbiome-immune-crosstalk
#27
REVIEW
Eléonore Beurel
The gut microbiota exerts a mutualistic interaction with the host in a fragile ecosystem and the host intestinal, neural, and immune cells. Perturbations of the gastrointestinal track composition after stress have profound consequences on the central nervous system and the immune system. Reciprocally, brain signals after stress affect the gut microbiota highlighting the bidirectional communication between the brain and the gut. Here, we focus on the potential role of inflammation in mediating stress-induced gut-brain changes and discuss the impact of several immune cells and inflammatory molecules of the gut-brain dialogue after stress...
2024: Gut Microbes
https://read.qxmd.com/read/38488562/magnesium-l-threonate-treats-alzheimer-s-disease-by-modulating-the-microbiota-gut-brain-axis
#28
JOURNAL ARTICLE
Wang Liao, Jiana Wei, Chongxu Liu, Haoyu Luo, Yuting Ruan, Yingren Mai, Qun Yu, Zhiyu Cao, Jiaxin Xu, Dong Zheng, Zonghai Sheng, Xianju Zhou, Jun Liu
JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer's disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer's disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1 (APP/PS1)...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488560/small-extracellular-vesicles-from-hypoxia-preconditioned-bone-marrow-mesenchymal-stem-cells-attenuate-spinal-cord-injury-via-mir-146a-5p-mediated-regulation-of-macrophage-polarization
#29
JOURNAL ARTICLE
Zeyan Liang, Zhelun Yang, Haishu Xie, Jian Rao, Xiongjie Xu, Yike Lin, Chunhua Wang, Chunmei Chen
JOURNAL/nrgr/04.03/01300535-202410000-00027/figure1/v/2024-02-06T055622Z/r/image-tiff Spinal cord injury is a disabling condition with limited treatment options. Multiple studies have provided evidence suggesting that small extracellular vesicles (SEVs) secreted by bone marrow mesenchymal stem cells (MSCs) help mediate the beneficial effects conferred by MSC transplantation following spinal cord injury. Strikingly, hypoxia-preconditioned bone marrow mesenchymal stem cell-derived SEVs (HSEVs) exhibit increased therapeutic potency...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488557/association-of-dna-methylation-demethylation-with-the-functional-outcome-of-stroke-in-a-hyperinflammatory-state
#30
JOURNAL ARTICLE
Yubo Wang, Ling Zhang, Tianjie Lyu, Lu Cui, Shunying Zhao, Xuechun Wang, Meng Wang, Yongjun Wang, Zixiao Li
JOURNAL/nrgr/04.03/01300535-202410000-00024/figure1/v/2024-02-06T055622Z/r/image-tiff Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488556/unraveling-the-gut-brain-axis-the-impact-of-steroid-hormones-and-nutrition-on-parkinson-s-disease
#31
JOURNAL ARTICLE
Paula Maria Neufeld, Ralf A Nettersheim, Veronika Matschke, Matthias Vorgerd, Sarah Stahlke, Carsten Theiss
This comprehensive review explores the intricate relationship between nutrition, the gut microbiome, steroid hormones, and Parkinson's disease within the context of the gut-brain axis. The gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease, encompassing diverse components such as the gut microbiota, immune system, metabolism, and neural pathways. The gut microbiome, profoundly influenced by dietary factors, emerges as a key player. Nutrition during the first 1000 days of life shapes the gut microbiota composition, influencing immune responses and impacting both child development and adult health...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488552/metabolic-reprogramming-of-the-inflammatory-response-in-the-nervous-system-the-crossover-between-inflammation-and-metabolism
#32
JOURNAL ARTICLE
Jesus Amo-Aparicio, Charles A Dinarello, Ruben Lopez-Vales
Metabolism is a fundamental process by which biochemicals are broken down to produce energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38486824/static-magnetic-fields-in-regenerative-medicine
#33
REVIEW
Wenjing Xie, Chao Song, Ruowen Guo, Xin Zhang
All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine...
March 2024: APL Bioengineering
https://read.qxmd.com/read/38485033/zeb2-alleviates-hirschsprung-s-associated-enterocolitis-by-promoting-the-proliferation-and-differentiation-of-enteric-neural-precursor-cells-via-the-notch-1-jagged-2-pathway
#34
JOURNAL ARTICLE
Yong Feng, Chonggao Zhou, Fan Zhao, Tidong Ma, Yong Xiao, Kun Peng, Renpeng Xia
BACKGROUND: Hirschsprung's-associated enterocolitis (HAEC) is a prevalent complication of Hirschsprung's disease (HSCR). Zinc finger E-box binding homeobox 2 (ZEB2) and Notch-1/Jagged-2 are dysregulated in HSCR, but their role in HAEC progression remains poorly understood. We aimed to explore the role and underlying mechanism of enteric neural precursor cells (ENPCs) and the ZEB2/Notch-1/Jagged-2 pathway in HAEC development. METHODS: Colon tissues were collected from HSCR and HAEC patients...
March 12, 2024: Gene
https://read.qxmd.com/read/38483364/clinical-grade-human-embryonic-stem-cell-derived-mesenchymal-stromal-cells-ameliorate-diabetic-retinopathy-in-db-db-mice
#35
JOURNAL ARTICLE
Liyuan Rong, Wumei Wei, Yifan Fang, Yanchen Liu, Tingting Gao, Liu Wang, Jie Hao, Xianliang Gu, Jun Wu, Wei Wu
BACKGROUND AIMS: Mesenchymal stromal cells (MSCs) hold great promise in the treatment of diabetic retinopathy (DR), as evidenced by increasing preclinical and clinical studies. However, the absence of standardized and industrialized clinical-grade donor cells hampers the continued development and large-scale clinical application of MSCs-based therapies for DR. Previously, we have identified a unique population of MSCs generated from a clinical-grade human embryonic stem cell (hESC) line under Good Manufacturing Practice conditions that could be a potential source to address the issues...
March 4, 2024: Cytotherapy
https://read.qxmd.com/read/38481633/apoptosis-and-turnover-disruption-of-olfactory-sensory-neurons-in-eosinophilic-chronic-rhinosinusitis
#36
REVIEW
Yuetong Chen, Minghan Li, Juan Lu
Olfactory dysfunction (OD) is one of the important and difficult-to-treat symptoms of eosinophilic chronic rhinosinusitis (CRS), which is typically associated with type 2 inflammation where eosinophils (EOSs) function as both effectors and initiators. Eosinophilic infiltration in the olfactory mucosa (OM) is associated with severe OD, mucosal erosion, and more loss of olfactory sensory neurons (OSNs). Active EOS-derived cytokines, chemokines, and eosinophil granule proteins may lead to aggravation of inflammation, tissue damage, and impairment of the survival and regeneration of OSNs...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38479999/brain-sodium-sensing-for-regulation-of-thirst-salt-appetite-and-blood-pressure
#37
REVIEW
Takeshi Y Hiyama
The brain possesses intricate mechanisms for monitoring sodium (Na) levels in body fluids. During prolonged dehydration, the brain detects variations in body fluids and produces sensations of thirst and aversions to salty tastes. At the core of these processes Nax , the brain's Na sensor, exists. Specialized neural nuclei, namely the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), which lack the blood-brain barrier, play pivotal roles. Within the glia enveloping the neurons in these regions, Nax collaborates with Na+ /K+ -ATPase and glycolytic enzymes to drive glycolysis in response to elevated Na levels...
March 2024: Physiological Reports
https://read.qxmd.com/read/38479055/humoral-immune-transcriptome-signature-in-myelomeningocele-patients
#38
JOURNAL ARTICLE
Rfm Felício, Almm Franco, D Corrêa-Moreira, F Martinez de Carvalho, Acr Guimarães, F R Vargas
INTRODUCTION: Myelomeningocele (MMC) results from incomplete closure of the neural tube, and has a complex multifactorial etiology, including an inflammatory microenvironment. OBJECTIVE: We evaluated the contribution of humoral immune response for development of inflammatory milieu. METHODS: Using public repository Gene Expression Omnibus (GEO), we retrieve dataset transcriptome from the amniotic fluid of ten fetuses with myelomeningocele and ten healthy control fetuses to found differential gene expression associated with disturbances and inflammatory signatures in MMC...
March 8, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38475915/chronological-transitions-of-hepatocyte-growth-factor-treatment-effects-in-spinal-cord-injury-tissue
#39
JOURNAL ARTICLE
Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura, Hideyuki Okano
Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and immunomodulation, such as the hepatocyte growth factor (HGF)/MET signaling cascade, have garnered significant attention. Notably, various studies, including our own, have highlighted the enhanced recovery of locomotor functions achieved in SCI animal models by combining HGF pretreatment and human induced stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) transplantation...
March 13, 2024: Inflammation and Regeneration
https://read.qxmd.com/read/38474360/neuroprotective-and-anti-inflammatory-activities-of-hybrid-small-molecule-sa-10-in-ischemia-reperfusion-induced-retinal-neuronal-injury-models
#40
JOURNAL ARTICLE
Charles E Amankwa, Lorea Gamboa Acha, Adnan Dibas, Sai H Chavala, Steven Roth, Biji Mathew, Suchismita Acharya
UNLABELLED: Embolism, hyperglycemia, high intraocular pressure-induced increased reactive oxygen species (ROS) production, and microglial activation result in endothelial/retinal ganglion cell death. Here, we conducted in vitro and in vivo ischemia/reperfusion (I/R) efficacy studies of a hybrid antioxidant-nitric oxide donor small molecule, SA-10, to assess its therapeutic potential for ocular stroke. METHODS: To induce I/R injury and inflammation, we subjected R28 and primary microglial cells to oxygen glucose deprivation (OGD) for 6 h in vitro or treated these cells with a cocktail of TNF-α, IL-1β and IFN-γ for 1 h, followed by the addition of SA-10 (10 µM)...
February 25, 2024: Cells
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