Usha Nekanti, Pooja S Sakthivel, Atena Zahedi, Dana A Creasman, Rebecca A Nishi, Courtney M Dumont, Katja M Piltti, Glenn L Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian T David, Zhiling Guo, Stephanie K Seidlits, Xiangmin Xu, Lonnie D Shea, Brian J Cummings, Aileen J Anderson
Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a permissive environment for rapid cellularization and robust axonal regrowth through this otherwise inhibitory milieu. However, without additional intervention, regenerated axons remain largely unmyelinated (<10%), limiting functional repair. While transplanted human neural stem cells (hNSC) myelinate axons after spinal cord injury (SCI), hNSC fate is highly influenced by the SCI inflammatory microenvironment, also limiting functional repair...
March 18, 2024: NPJ Regenerative Medicine