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malaria colombia clinical case

Jesica F Ramírez, Beatriz Porras, Elizabeth Borrero, Sandra P Martínez
BACKGROUND: Malaria worldwide annual reported cases range between 250 and 500 million and nearly half a million deaths are reported every year. Colombia has a vast expanse of territory with environmental and social conditions conducive to malaria transmission, which is the reason why it has second place in Latin America for the number of cases of malaria. METHODS: This is a retrospective, paired, case-control study that compares patients with severe malaria and malaria patients without mention of complication...
October 19, 2016: Malaria Journal
Pablo E Chaparro-Narváez, Mary Lopez-Perez, Lina Marcela Rengifo, Julio Padilla, Sócrates Herrera, Myriam Arévalo-Herrera
BACKGROUND: During the last decade, Colombia presented a significant decrease in malaria clinical cases and associated mortality. However, there is a lack of reliable information about the prevalence and characteristics of complicated malaria cases as well as its association with different Plasmodium species. A description of the epidemiological and clinical aspects of complicated malaria in Colombia is presented here. METHODS: A descriptive study was conducted using data collected between 2007 and 2013 by the Public Health Surveillance System (SIVIGILA)...
2016: Malaria Journal
Juan M Vásquez-Jiménez, Myriam Arévalo-Herrera, Juliana Henao-Giraldo, Karen Molina-Gómez, María Arce-Plata, Andrés F Vallejo, Sócrates Herrera
BACKGROUND: Malaria control programmes rely on confirmation of parasite presence in patients' blood prior to treatment administration. Plasmodium parasites are detected mostly by microscopy or rapid diagnostic test (RDT). Although these methods contribute significantly to malaria control/elimination, they are not suitable for detecting the significant proportion of asymptomatic subjects harbouring low levels of parasitaemia, which endure untreated as potential reservoirs for transmission...
2016: Malaria Journal
Mary Lopez-Perez, M Andreína Pacheco, Lucía Buriticá, Ananias A Escalante, Sócrates Herrera, Myriam Arévalo-Herrera
BACKGROUND: Malaria causes a significant burden in highly endemic areas where children and pregnant women are more susceptible to severe disease and death, however, in low transmission settings malaria in pregnant women is less frequent. The aim of this study was to provide information of clinical profile, anti-parasite host immune responses and parasite genotyping of pregnant women with malaria in low endemic areas of Colombia. METHODS: This was a descriptive study conducted through passive surveillance in 1328 individuals from three endemic areas of Córdoba, Nariño and Chocó departments between 2011 and 2013...
2016: Malaria Journal
Myriam Arévalo-Herrera, Mary Lopez-Perez, Luz Medina, Alberto Moreno, Juan B Gutierrez, Sócrates Herrera
BACKGROUND: Malaria transmission in Latin America is generally hypoendemic and unstable, with Plasmodium vivax as the most prevalent species. However, only a few studies have been carried out in areas with low and unstable transmission, whereas the clinical profile of malaria has been broadly described in hyperendemic areas. The pattern of clinical manifestations and laboratory findings in low to moderate endemic areas of Colombia is reported here. METHODS: A passive surveillance study was conducted between 2011 and 2013 involving 1,328 patients with Plasmodium falciparum, P...
2015: Malaria Journal
Celia M Alpuche-Aranda, Hugo Lopez-Gatell
No abstract text is available yet for this article.
2015: Recent Patents on Anti-infective Drug Discovery
Anthony T O'Brien, Jesica F Ramírez, Sandra P Martínez
BACKGROUND: Plasmodium vivax, the most geographically distributed cause of malaria, accounts for more than 70% of cases in the Americas. In Colombia, P. vivax was responsible for 67.3% of cases in the last five years. Despite vivax malaria impact worldwide, historically it has been neglected and considered to be a benign disease. In the last decade medical literature reports have emerged countering this benign outlook. This study pretends to describe the clinical and paraclinical profile of severe vivax malaria cases hospitalized in Tumaco, Cali, Buenaventura between 2009 and 2013, to contribute to the knowledge regarding the behaviour and clinical expression of this disease...
2014: Malaria Journal
Olga M Agudelo, Beatriz H Aristizabal, Stephanie K Yanow, Eliana Arango, Jaime Carmona-Fonseca, Amanda Maestre
BACKGROUND: A large-scale study was set up in order to study the epidemiology, clinical aspects, and immunopathology of gestational and placental malaria in north-west Colombia. In this region, recent reports using a qPCR technique, confirmed frequencies of infection, by Plasmodium falciparum or Plasmodium vivax, up to 45%. Given the high rates of infection observed both in mother and placenta, a first exploratory study was proposed in order to characterize the effect on the inflammation status, tissue damage and hypoxia in Plasmodium spp...
2014: Malaria Journal
Esteban Arroyave, Andrés Felipe Londoño, Juan Carlos Quintero, Piedad Agudelo-Flórez, Margarita Arboleda, Francisco J Díaz, Juan D Rodas
INTRODUCTION: Urabá, a region on the northern coast of Colombia, is endemic to several acute febrile illnesses of infectious origin; however, only patients with malaria may have access to quick and effective diagnosis. For this reason, many non-malarial febrile patients go without a clear etiologic diagnosis. AIM: To establish the etiology and clinical signs of acute febrile non-malaria syndromes and explore some of the likely risk factors in patients originating in the municipalities of Necocli, Turbo and Apartado who exhibit these symptoms...
September 2013: Biomédica: Revista del Instituto Nacional de Salud
Anastasios Ioannidis, Chryssoula Nicolaou, Athina Stoupi, Athanasios Kossyvakis, Petros Matsoukas, Melina-Vassiliki Liakata, Emmanouil Magiorkinis, Efthimia Petinaki, Stylianos Chatzipanagiotou
Malaria has become an emerging infection in Greece, which is the doorstep to Europe for thousands of immigrants. With increasing immigration, cases with evidence of domestic transmission (autochthonous) are being reported. In the present study, an isolate of Plasmodium vivax from an autochthonous clinical case was subjected to phylogenetic analysis of the genes encoding the merozoite surface protein 1 (MSP-1) and the circumsporozoite protein (CSP). In the MSP region, the strain was related with strains from Brazil, South Korea, Turkey and Thailand, whereas in the CSP region, with strains from Brazil, Colombia and New Guinea...
2013: Malaria Journal
Juan Gabriel Piñeros, Alberto Tobon-Castaño, Gonzalo Alvarez, Carmencita Portilla, Silvia Blair
In malaria-endemic regions of Latin America, little is known about malaria in pregnancy. To characterize the clinical and laboratory findings of maternal infection, we evaluated 166 cases of pregnant women infected with Plasmodium spp. in a prospective study conducted in northwestern Colombia during 2005-2006. A total of 89.8% (149 of 166) had fever or a history of fever in the past 48 hours, 9.0% (15 of 166) had severe malaria, of which 66.7% was caused by Plasmodium vivax and 33.3% by P. falciparum. Hepatic dysfunction was the main complication (9 of 15) observed...
September 2013: American Journal of Tropical Medicine and Hygiene
Alberto Tobón Castaño, Ana del Mar Cortina, Andrés Felipe Miranda, Silvia Blair Trujillo
INTRODUCTION: early recognition of warning signs in malarial patients allows timely identification of the patient at risk of severe malaria and provides opportune treatment. Jaundice and dark urine are frequent signs that can alert to the occurrence of severe malaria. OBJECTIVE: to study the relationship between jaundice and dark urine with impaired liver and/or kidney function and anemia in malarial patients, and explore their role as warning signs. METHOD: clinical and laboratory data from 199 patients with Plasmodium falciparum malaria, belonging to a case control study conducted in Colombia, were analyzed, the association between dark urine and jaundice with impairment in the urine analysis, the hepatic and renal function test, and hemoglobin were studied...
January 2010: Revista Cubana de Medicina Tropical
Margarita Arboleda, María Fernanda Pérez, Diana Fernández, Luz Yaned Usuga, Miler Meza
INTRODUCTION: Malaria is a public health problem in the Urabá region recording rates of infection above those of the Antioquia department. The burden of vivax malaria is 78.7% and the profile of vivax malaria in this region has scarcely been studied. OBJECTIVES: To analyze the clinical and laboratory characteristics of patients hospitalized for vivax malaria in Apartadó. MATERIALS AND METHODS: We reviewed the medical records of patients with vivax malaria hospitalized in the Antonio Roldán Betancur hospital from 2004-2007...
March 2012: Biomédica: Revista del Instituto Nacional de Salud
Julio Cesar Padilla Rodríguez, Gilberto Álvarez Uribe, Roberto Montoya Araújo, Pablo Chaparro Narváez, Sócrates Herrera Valencia
Malaria is currently one of the most serious public health problems in Colombia with an endemic/epidemic transmission pattern that has maintained endemic levels and an average of 105,000 annual clinical cases being reported over the last five years. Plasmodium vivax accounts for approximately 70% of reported cases with the remainder attributed almost exclusively to Plasmodium falciparum. A limited number of severe and complicated cases have resulted in mortality, which is a downward trend that has been maintained over the last few years...
August 2011: Memórias do Instituto Oswaldo Cruz
Juan G Piñeros-Jiménez, Gonzalo Álvarez, Alberto Tobón, Margarita Arboleda, Sonia Carrero, Silvia Blair
BACKGROUND: Congenital malaria has been considered a rare event; however, recent reports have shown frequencies ranging from 3% to 54.2% among newborns of mothers who had suffered malaria during pregnancy. There are only a few references concerning the epidemiological impact of this entity in Latin-America and Colombia. OBJECTIVE: The aim of the study was to measure the prevalence of congenital malaria in an endemic Colombian region and to determine some of its characteristics...
2011: Malaria Journal
Sócrates Herrera, Martha Lucia Quiñones, Juan Pablo Quintero, Vladimir Corredor, Douglas O Fuller, Julio Cesar Mateus, Jose E Calzada, Juan B Gutierrez, Alejandro Llanos, Edison Soto, Clara Menendez, Yimin Wu, Pedro Alonso, Gabriel Carrasquilla, Mary Galinski, John C Beier, Myriam Arévalo-Herrera
Latin America contributes 1-1.2 million clinical malaria cases to the global malaria burden of about 300 million per year. In 21 malaria endemic countries, the population at risk in this region represents less than 10% of the total population exposed worldwide. Factors such as rapid deforestation, inadequate agricultural practices, climate change, political instability, and both increasing parasite drug resistance and vector resistance to insecticides contribute to malaria transmission. Recently, several malaria endemic countries have experienced a significant reduction in numbers of malaria cases...
March 2012: Acta Tropica
Juan Gabriel Piñeros-Jiménez, Margarita Arboleda, Juan Camilo Jaramillo, Silvia Blair
INTRODUCTION: Neonatal malaria is a type of malaria that occurs during the first month of life. In the last half century, the reports of malaria parasites in neonates generally have been associated with congenital transmission. However, in recent years, cases have appeared with increasing frequency, especially in Africa. In Latin America, the incidence of neonatal malaria is unknown, with only isolated cases reported. OBJECTIVE: Cases of neonatal malaria were identified and characterized to better recognize the frequency and symptoms of cases as they occur in Colombia...
December 2008: Biomédica: Revista del Instituto Nacional de Salud
Paula Montoya, Alberto Tobón, Silvia Blair, Jaime Carmona, Amanda Maestre
INTRODUCTION: The pfmdr1 gene of Plasmodium falciparum has been described as a gene conferring resistance to several antimalarial drugs. In particular, polymorphisms on specific codons have been associated with resistance and treatment failure with cloroquine, amodiaquine and mefloquine. However, the role of these polymorphisms in treatment response to antimalarials remains unexplored in Colombia. Furthermore, the relationship of these polymorphisms to severe malaria is unknown. OBJECTIVE: This work studied the association of the Asn 86Tyr and Asp1246Tyr pfmdr1 polymorphisms with response to cloroquine, amodiaquine and mefloquine treatment in three municipalities of Antioquia, and severe malaria cases from the municipality Tumaco...
June 2007: Biomédica: Revista del Instituto Nacional de Salud
Lina Zuluaga, Adriana Pabón, Carlos López, Aleida Ochoa, Silvia Blair
OBJECTIVE: To establish the relationship between production of glutathione and the therapeutic response to amodiaquine (AQ) monotherapy in Plasmodium falciparum non-complicated malaria patients. METHODOLOGY: Therapeutic response to AQ was evaluated in 32 patients with falciparum malaria in two townships of Antioquia, Colombia, and followed-up for 28 days. For every patient, total glutathione and enzymatic activity (glutathione reductase, GR, and gamma-glutamylcysteine synthetase, gamma-GCS) were determined in parasitized erythrocytes, non-infected erythrocytes and free parasites, on the starting day (day zero, before ingestion of AQ) and on the day of failure (in case of occurrence)...
2007: Malaria Journal
Lyda Osorio, Iveth Gonzalez, Piero Olliaro, Walter R J Taylor
BACKGROUND: Artemisinin-based combination therapy (ACT) is being widely promoted as a strategy to counteract the increase in Plasmodium falciparum antimalarial drug resistance. METHODS: A randomized, double-blind, placebo-controlled, clinical trial of the efficacy, effect on gametocytes and safety of the addition of artesunate/placebo (4 mg/kg/day x 3 d) to amodiaquine (10 mg/kg/day x 3 d) was conducted in Choco department, a low intensity transmission area in northwest Colombia...
2007: Malaria Journal
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