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https://www.readbyqxmd.com/read/28630631/urinalysis-and-clinical-correlations-in-patients-with-p-vivax-or-p-falciparum-malaria-from-colombia
#1
Alberto Tobón-Castaño, Sebastián Barrera Escobar, Cecilia Giraldo Castro
BACKGROUND: Urinalysis is a poorly reviewed diagnostic tool in malaria patients; its application can show the presence of severe malaria. METHODS: Urinalysis was performed in a total of 620 patients diagnosed with malaria by thick blood smear; complications were classified according to WHO major criteria for severity and minor criteria according to the Colombian malaria guideline. RESULTS: Severe or moderate clinical complications were diagnosed in 31...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28604825/burden-and-impact-of-plasmodium-vivax-in-pregnancy-a-multi-centre-prospective-observational-study
#2
Azucena Bardají, Flor Ernestina Martínez-Espinosa, Myriam Arévalo-Herrera, Norma Padilla, Swati Kochar, Maria Ome-Kaius, Camila Bôtto-Menezes, María Eugenia Castellanos, Dhanpat Kumar Kochar, Sanjay Kumar Kochar, Inoni Betuela, Ivo Mueller, Stephen Rogerson, Chetan Chitnis, Dhiraj Hans, Michela Menegon, Carlo Severini, Hernando Del Portillo, Carlota Dobaño, Alfredo Mayor, Jaume Ordi, Mireia Piqueras, Sergi Sanz, Mats Wahlgren, Laurence Slutsker, Meghna Desai, Clara Menéndez
BACKGROUND: Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy. METHODOLOGY AND PRINCIPAL FINDINGS: We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28460112/baseline-in-vivo-ex-vivo-and-molecular-responses-of-plasmodium-falciparum-to-artemether-and-lumefantrine-in-three-endemic-zones-for-malaria-in-colombia
#3
Samanda Aponte, Ángela Patricia Guerra, Catalina Álvarez-Larrotta, Sindy Durley Bernal, César Restrepo, Camila González, María Fernanda Yasnot, Angélica Knudson-Ospina
Background: Colombia began using artemisinin-based combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in 2006. It is necessary to implement resistance surveillance to antimalarial drugs in order to promptly detect changes in parasite susceptibility. The aim of this study was to establish a susceptibility baseline of P. falciparum to artemether-lumefantrine using three monitoring tools. Methods: Patients with uncomplicated malaria treated with artemether-lumefantrine underwent clinical and parasitological follow-up over 28 days...
February 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28162961/undifferentiated-tropical-febrile-illness-in-cordoba-colombia-not-everything-is-dengue
#4
Salim Mattar, Vaneza Tique, Jorge Miranda, Eney Montes, Denisses Garzon
In Colombia, undifferentiated tropical febrile illness (UTFI) are frequent and of considerable concern. They also share many clinical features. Between 2012 and 2013 in an endemic tropical area of Cordoba, Colombia, we conducted a prospective study to establish an etiological diagnosis of UTFI. Using diagnostic tests for dengue, leptospirosis, hantavirus, malaria, rickettsia, brucellosis, hepatitis A and B on 100 patients recruited for the study. We identified 69 patients with presumed UTFI: leptospirosis (n=27), dengue (n=26), hantavirus infection (n=4), malaria (n=4), rickettsial infection (n=2), hepatitis A (n=1), and brucellosis (n=1); no hepatitis B cases were detected...
February 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/27956060/plasmodium-vivax-controlled-human-malaria-infection-progress-and-prospects
#5
REVIEW
Ruth O Payne, Paul M Griffin, James S McCarthy, Simon J Draper
Modern controlled human malaria infection (CHMI) clinical trials have almost entirely focussed on Plasmodium falciparum, providing a highly informative means to investigate host-pathogen interactions as well as assess potential new prophylactic and therapeutic interventions. However, in recent years, there has been renewed interest in Plasmodium vivax, with CHMI models developed by groups in Colombia, the USA, and Australia. This review summarizes the published experiences, and examines the advantages and disadvantages of the different models that initiate infection either by mosquito bite or using a blood-stage inoculum...
February 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/27760545/factors-associated-with-the-severity-and-complication-of-patients-with-malaria-hospitalized-between-2009-and-2013-in-three-municipalities-of-colombia-case-control-study
#6
Jesica F Ramírez, Beatriz Porras, Elizabeth Borrero, Sandra P Martínez
BACKGROUND: Malaria worldwide annual reported cases range between 250 and 500 million and nearly half a million deaths are reported every year. Colombia has a vast expanse of territory with environmental and social conditions conducive to malaria transmission, which is the reason why it has second place in Latin America for the number of cases of malaria. METHODS: This is a retrospective, paired, case-control study that compares patients with severe malaria and malaria patients without mention of complication...
October 19, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27467587/high-plasmodium-malariae-prevalence-in-an-endemic-area-of-the-colombian-amazon-region
#7
Paola Andrea Camargo-Ayala, Juan Ricardo Cubides, Carlos Hernando Niño, Milena Camargo, Carlos Arturo Rodríguez-Celis, Teódulo Quiñones, Lizeth Sánchez-Suárez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
Malaria is a worldwide public health problem; parasites from the genus Plasmodium are the aetiological agent for this disease. The parasites are mostly diagnosed by conventional microscopy-based techniques; however, their limitations have led to under-registering the reported prevalence of Plasmodium species. This study has thus been aimed at evaluating the infection and coinfection prevalence of 3 species of Plasmodium spp., in an area of the Colombian Amazon region. Blood samples were taken from 671 symptomatic patients by skin puncture; a nested PCR amplifying the 18S ssRNA region was used on all samples to determine the presence of P...
2016: PloS One
https://www.readbyqxmd.com/read/27165306/clinical-and-epidemiological-aspects-of-complicated-malaria-in-colombia-2007-2013
#8
Pablo E Chaparro-Narváez, Mary Lopez-Perez, Lina Marcela Rengifo, Julio Padilla, Sócrates Herrera, Myriam Arévalo-Herrera
BACKGROUND: During the last decade, Colombia presented a significant decrease in malaria clinical cases and associated mortality. However, there is a lack of reliable information about the prevalence and characteristics of complicated malaria cases as well as its association with different Plasmodium species. A description of the epidemiological and clinical aspects of complicated malaria in Colombia is presented here. METHODS: A descriptive study was conducted using data collected between 2007 and 2013 by the Public Health Surveillance System (SIVIGILA)...
May 10, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27014875/antibody-profiling-in-na%C3%A3-ve-and-semi-immune-individuals-experimentally-challenged-with-plasmodium-vivax-sporozoites
#9
Myriam Arévalo-Herrera, Mary Lopez-Perez, Emmanuel Dotsey, Aarti Jain, Kelly Rubiano, Philip L Felgner, D Huw Davies, Sócrates Herrera
BACKGROUND: Acquisition of malaria immunity in low transmission areas usually occurs after relatively few exposures to the parasite. A recent Plasmodium vivax experimental challenge trial in malaria naïve and semi-immune volunteers from Colombia showed that all naïve individuals developed malaria symptoms, whereas semi-immune subjects were asymptomatic or displayed attenuated symptoms. Sera from these individuals were analyzed by protein microarray to identify antibodies associated with clinical protection...
March 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26875608/impact-of-malaria-in-pregnancy-as-latin-america-approaches-elimination
#10
REVIEW
Stephanie K Yanow, Kenneth Gavina, Sedami Gnidehou, Amanda Maestre
In Latin America, four million pregnancies are at risk of malaria annually, but malaria in pregnancy is largely overlooked. As countries progress toward malaria elimination, targeting reservoirs of transmission is a priority. Pregnant women are an important risk group because they harbor asymptomatic infections and dormant liver stages of Plasmodium vivax that cause relapses. Of significant concern is the discovery that most infections in pregnant women fail to be detected by routine diagnostics. We review here recent findings on malaria in pregnancy within Latin America...
May 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/26852321/consistent-prevalence-of-asymptomatic-infections-in-malaria-endemic-populations-in-colombia-over-time
#11
Juan M Vásquez-Jiménez, Myriam Arévalo-Herrera, Juliana Henao-Giraldo, Karen Molina-Gómez, María Arce-Plata, Andrés F Vallejo, Sócrates Herrera
BACKGROUND: Malaria control programmes rely on confirmation of parasite presence in patients' blood prior to treatment administration. Plasmodium parasites are detected mostly by microscopy or rapid diagnostic test (RDT). Although these methods contribute significantly to malaria control/elimination, they are not suitable for detecting the significant proportion of asymptomatic subjects harbouring low levels of parasitaemia, which endure untreated as potential reservoirs for transmission...
February 6, 2016: Malaria Journal
https://www.readbyqxmd.com/read/26850108/malaria-in-pregnancy-a-passive-surveillance-study-of-pregnant-women-in-low-transmission-areas-of-colombia-latin-america
#12
Mary Lopez-Perez, M Andreína Pacheco, Lucía Buriticá, Ananias A Escalante, Sócrates Herrera, Myriam Arévalo-Herrera
BACKGROUND: Malaria causes a significant burden in highly endemic areas where children and pregnant women are more susceptible to severe disease and death, however, in low transmission settings malaria in pregnant women is less frequent. The aim of this study was to provide information of clinical profile, anti-parasite host immune responses and parasite genotyping of pregnant women with malaria in low endemic areas of Colombia. METHODS: This was a descriptive study conducted through passive surveillance in 1328 individuals from three endemic areas of Córdoba, Nariño and Chocó departments between 2011 and 2013...
February 5, 2016: Malaria Journal
https://www.readbyqxmd.com/read/26664413/leukogram-profile-and-clinical-status-in-vivax-and-falciparum-malaria-patients-from-colombia
#13
Alberto Tobón-Castaño, Esteban Mesa-Echeverry, Andrés Felipe Miranda-Arboleda
Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. Methods...
2015: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/26464073/an-gambiae-gsg6-p1-evaluation-as-a-proxy-for-human-vector-contact-in-the-americas-a-pilot-study
#14
Berlin Londono-Renteria, Papa M Drame, Thomas Weitzel, Reinaldo Rosas, Crystal Gripping, Jenny C Cardenas, Marcela Alvares, Dawn M Wesson, Anne Poinsignon, Franck Remoue, Tonya M Colpitts
BACKGROUND: During blood meal, the female mosquito injects saliva able to elicit an immune response in the vertebrate. This immune response has been proven to reflect the intensity of exposure to mosquito bites and risk of infection for vector transmitted pathogens such as malaria. The peptide gSG6-P1 of An. gambiae saliva has been demonstrated to be antigenic and highly specific to Anopheles as a genus. However, the applicability of gSG6-P1 to measure exposure to different Anopheles species endemic in the Americas has yet to be evaluated...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/26244760/transcription-profiling-of-malaria-na%C3%A3-ve-and-semi-immune-colombian-volunteers-in-a-plasmodium-vivax-sporozoite-challenge
#15
Monica L Rojas-Peña, Andres Vallejo, Sócrates Herrera, Greg Gibson, Myriam Arévalo-Herrera
BACKGROUND: Continued exposure to malaria-causing parasites in endemic regions of malaria induces significant levels of acquired immunity in adult individuals. A better understanding of the transcriptional basis for this acquired immunological response may provide insight into how the immune system can be boosted during vaccination, and into why infected individuals differ in symptomology. METHODOLOGY/PRINCIPAL FINDINGS: Peripheral blood gene expression profiles of 9 semi-immune volunteers from a Plasmodium vivax malaria prevalent region (Buenaventura, Colombia) were compared to those of 7 naïve individuals from a region with no reported transmission of malaria (Cali, Colombia) after a controlled infection mosquito bite challenge with P...
2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25889074/clinical-profile-of-plasmodium-falciparum-and-plasmodium-vivax-infections-in-low-and-unstable-malaria-transmission-settings-of-colombia
#16
Myriam Arévalo-Herrera, Mary Lopez-Perez, Luz Medina, Alberto Moreno, Juan B Gutierrez, Sócrates Herrera
BACKGROUND: Malaria transmission in Latin America is generally hypoendemic and unstable, with Plasmodium vivax as the most prevalent species. However, only a few studies have been carried out in areas with low and unstable transmission, whereas the clinical profile of malaria has been broadly described in hyperendemic areas. The pattern of clinical manifestations and laboratory findings in low to moderate endemic areas of Colombia is reported here. METHODS: A passive surveillance study was conducted between 2011 and 2013 involving 1,328 patients with Plasmodium falciparum, P...
2015: Malaria Journal
https://www.readbyqxmd.com/read/25851254/chikungunya-the-2014-emerging-infectious-diseases-in-the-americas
#17
EDITORIAL
Celia M Alpuche-Aranda, Hugo Lopez-Gatell
No abstract text is available yet for this article.
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/25318617/a-descriptive-study-of-16-severe-plasmodium-vivax-cases-from-three-municipalities-of-colombia-between-2009-and-2013
#18
Anthony T O'Brien, Jesica F Ramírez, Sandra P Martínez
BACKGROUND: Plasmodium vivax, the most geographically distributed cause of malaria, accounts for more than 70% of cases in the Americas. In Colombia, P. vivax was responsible for 67.3% of cases in the last five years. Despite vivax malaria impact worldwide, historically it has been neglected and considered to be a benign disease. In the last decade medical literature reports have emerged countering this benign outlook. This study pretends to describe the clinical and paraclinical profile of severe vivax malaria cases hospitalized in Tumaco, Cali, Buenaventura between 2009 and 2013, to contribute to the knowledge regarding the behaviour and clinical expression of this disease...
2014: Malaria Journal
https://www.readbyqxmd.com/read/25269993/low-genetic-diversity-in-the-locus-encoding-the-plasmodium-vivax-p41-protein-in-colombia-s-parasite-population
#19
Johanna Forero-Rodríguez, Diego Garzón-Ospina, Manuel A Patarroyo
BACKGROUND: The development of malaria vaccine has been hindered by the allele-specific responses produced by some parasite antigens' high genetic diversity. Such antigen genetic diversity must thus be evaluated when designing a completely effective vaccine. Plasmodium falciparum P12, P38 and P41 proteins have red blood cell binding regions in the s48/45 domains and are located on merozoite surface, P41 forming a heteroduplex with P12. These three genes have been identified in Plasmodium vivax and share similar characteristics with their orthologues in Plasmodium falciparum...
2014: Malaria Journal
https://www.readbyqxmd.com/read/25075486/platelet-profile-is-associated-with-clinical-complications-in-patients-with-vivax-and-falciparum-malaria-in-colombia
#20
Edgar Leonardo Martínez-Salazar, Alberto Tobón-Castaño
INTRODUCTION: Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status...
May 2014: Revista da Sociedade Brasileira de Medicina Tropical
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