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https://www.readbyqxmd.com/read/28636935/the-sensory-striatum-is-permanently-impaired-by-transient-developmental-deprivation
#1
Todd M Mowery, Kristina B Penikis, Stephen K Young, Christopher E Ferrer, Vibhakar C Kotak, Dan H Sanes
Corticostriatal circuits play a fundamental role in regulating many behaviors, and their dysfunction is associated with many neurological disorders. In contrast, sensory disorders, like hearing loss (HL), are commonly linked with processing deficits at or below the level of the auditory cortex (ACx). However, HL can be accompanied by non-sensory deficits, such as learning delays, suggesting the involvement of regions downstream of ACx. Here, we show that transient developmental HL differentially affected the ACx and its downstream target, the sensory striatum...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28605494/glutamate-transport-a-new-bench-to-bedside-mechanism-for-treating-drug-abuse
#2
Sade Spencer, Peter W Kalivas
Drug addiction has often been described as a "hijacking" of the brain circuits involved in learning and memory. Glutamate is the principal excitatory neurotransmitter in the brain, and its contribution to synaptic plasticity and learning processes is well established in animal models. Likewise, over the past twenty years the addiction field has ascribed a critical role for glutamatergic transmission in the development of addiction. Chronic drug use produces enduring neuroadaptations in corticostriatal projections that are believed to contribute to a maladaptive deficit in inhibitory control over behavior...
June 12, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28603856/a-case-for-motor-network-contributions-to-schizophrenia-symptoms-evidence-from-resting-state-connectivity
#3
Jessica A Bernard, James R M Goen, Ted Maldonado
Though schizophrenia (SCZ) is classically defined based on positive symptoms and the negative symptoms of the disease prove to be debilitating for many patients, motor deficits are often present as well. A growing literature highlights the importance of motor systems and networks in the disease, and it may be the case that dysfunction in motor networks relates to the pathophysiology and etiology of SCZ. To test this and build upon recent work in SCZ and in at-risk populations, we investigated cortical and cerebellar motor functional networks at rest in SCZ and controls using publically available data...
June 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28603489/corticostriatal-regulation-of-acute-pain
#4
Erik Martinez, Harvey H Lin, Haocheng Zhou, Jahrane Dale, Kevin Liu, Jing Wang
The mechanisms for acute pain regulation in the brain are not well understood. The prefrontal cortex (PFC) provides top-down control of emotional processes, and it projects to the nucleus accumbens (NAc). This corticostriatal projection forms an important regulatory pathway within the brain's reward system. Recently, this projection has been suggested to control both sensory and affective phenotypes specifically associated with chronic pain. As this projection is also known to play a role in the transition from acute to chronic pain, we hypothesized that this corticostriatal circuit can also exert a modulatory function in the acute pain state...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28571615/reinforcement-learning-computing-the-temporal-difference-of-values-via-distinct-corticostriatal-pathways-trends-in-neurosciences-35-457-467-2012
#5
Kenji Morita, Mieko Morishima, Katsuyuki Sakai, Yasuo Kawaguchi
No abstract text is available yet for this article.
May 29, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28562592/dynamic-corticostriatal-activity-biases-social-bonding-in-monogamous-female-prairie-voles
#6
Elizabeth A Amadei, Zachary V Johnson, Yong Jun Kwon, Aaron C Shpiner, Varun Saravanan, Wittney D Mays, Steven J Ryan, Hasse Walum, Donald G Rainnie, Larry J Young, Robert C Liu
Adult pair bonding involves dramatic changes in the perception and valuation of another individual. One key change is that partners come to reliably activate the brain's reward system, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females' affiliative behaviour towards a partner...
June 8, 2017: Nature
https://www.readbyqxmd.com/read/28560267/electroconvulsive-therapy-induced-brain-functional-connectivity-predicts-therapeutic-efficacy-in-patients-with-schizophrenia-a-multivariate-pattern-recognition-study
#7
Peng Li, Ri-Xing Jing, Rong-Jiang Zhao, Zeng-Bo Ding, Le Shi, Hong-Qiang Sun, Xiao Lin, Teng-Teng Fan, Wen-Tian Dong, Yong Fan, Lin Lu
Previous studies suggested that electroconvulsive therapy can influence regional metabolism and dopamine signaling, thereby alleviating symptoms of schizophrenia. It remains unclear what patients may benefit more from the treatment. The present study sought to identify biomarkers that predict the electroconvulsive therapy response in individual patients. Thirty-four schizophrenia patients and 34 controls were included in this study. Patients were scanned prior to treatment and after 6 weeks of treatment with antipsychotics only (n = 16) or a combination of antipsychotics and electroconvulsive therapy (n = 13)...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28540422/loss-and-remodeling-of-striatal-dendritic-spines-in-parkinson-s-disease-from-homeostasis-to-maladaptive-plasticity
#8
REVIEW
Rosa M Villalba, Yoland Smith
In Parkinson's disease (PD) patients and animal models of PD, the progressive degeneration of the nigrostriatal dopamine (DA) projection leads to two major changes in the morphology of striatal projection neurons (SPNs), i.e., a profound loss of dendritic spines and the remodeling of axospinous glutamatergic synapses. Striatal spine loss is an early event tightly associated with the extent of striatal DA denervation, but not the severity of parkinsonian motor symptoms, suggesting that striatal spine pruning might be a form of homeostatic plasticity that compensates for the loss of striatal DA innervation and the resulting dysregulation of corticostriatal glutamatergic transmission...
May 24, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28538517/greater-corticostriatal-activation-associated-with-facial-motor-imagery-compared-with-motor-execution-a-functional-mri-study
#9
Meena M Makary, Seulgi Eun, Kyungmo Park
Motor imagery (MI) relies on conscious mental simulation of a motor act without overt motor output and can promote motor skill acquisition and facilitate rehabilitation for patients with stroke or neurological conditions. Although a plethora of neuroimaging studies have investigated the neural network of MI regarding different body parts, exploration of the neural correlates to facial MI remains warranted. Here, we used functional MRI with a large cohort of 41 participants who underwent motor execution (ME) and MI runs of mouth-stretching tasks...
July 5, 2017: Neuroreport
https://www.readbyqxmd.com/read/28526611/alcohol-induces-input-specific-aberrant-synaptic-plasticity-in-the-rat-dorsomedial-striatum
#10
Tengfei Ma, Britton Barbee, Xuehua Wang, Jun Wang
Accumulated evidence suggests that the dorsomedial striatum (DMS) of the basal ganglia plays an essential role in pathological excessive alcohol consumption. The DMS receives multiple glutamatergic inputs. However, whether and how alcohol consumption distinctly affects these excitatory afferents to the DMS remains unknown. Here, we used optogenetics to selectively activate the rat medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) inputs in DMS slices, and measured the effects of alcohol consumption on glutamatergic transmission in these corticostriatal and amygdalostriatal circuits...
May 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28506437/association-between-interleukin-6-and-striatal-prediction-error-signals-following-acute-stress-in-healthy-female-participants
#11
Michael T Treadway, Roee Admon, Amanda R Arulpragasam, Malavika Mehta, Samuel Douglas, Gordana Vitaliano, David P Olson, Jessica A Cooper, Diego A Pizzagalli
BACKGROUND: Stress is widely known to alter behavioral responses to rewards and punishments. It is believed that stress may precipitate these changes through modulation of corticostriatal circuitry involved in reinforcement learning and motivation, although the intervening mechanisms remain unclear. One candidate is inflammation, which can rapidly increase following stress and can disrupt dopamine-dependent reward pathways. METHODS: Here, in a sample of 88 healthy female participants, we first assessed the effect of an acute laboratory stress paradigm on levels of plasma interleukin-6 (IL-6), a cytokine known to be both responsive to stress and elevated in depression...
March 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28496402/cortico-striatal-thalamic-loop-circuits-of-the-orbitofrontal-cortex-promising-therapeutic-targets-in-psychiatric-illness
#12
REVIEW
Peter Fettes, Laura Schulze, Jonathan Downar
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex human behaviors such as evaluation, affect regulation and reward-based decision-making. Importantly, the medial and lateral OFC (mOFC and lOFC) circuits have functionally and anatomically distinct connectivity profiles which differentially contribute to the various aspects of goal-directed behavior. OFC corticostriatal circuits have been consistently implicated across a wide range of psychiatric disorders, including major depressive disorder (MDD), obsessive compulsive disorder (OCD), and substance use disorders (SUDs)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28484419/altered-functional-connectivity-of-striatal-subregions-in-patients-with-multiple-sclerosis
#13
Fangyuan Cui, Li Zhou, Zengjian Wang, Courtney Lang, Joel Park, Zhongjian Tan, Yao Yu, Chunyan Sun, Ying Gao, Jian Kong
Abnormal corticostriatal resting-state functional connectivity (rsFC) has been implicated in the neuropathology of multiple sclerosis. The striatum, a component of the basal ganglia, is involved in diverse functions including movement, cognition, emotion, and limbic information processing. However, the brain circuits of the striatal subregions contributing to the changes in rsFC in relapsing-remitting multiple sclerosis (RRMS) patients remain unknown. We used six subdivisions of the striatum in each hemisphere as seeds to investigate the rsFC of striatal subregions between RRMS patients and matched healthy controls (HCs)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28476642/properties-of-the-corticostriatal-long-term-depression-induced-by-medial-prefrontal-cortex-high-frequency-stimulation-in%C3%A2-vivo
#14
Barbara Y Braz, Juan E Belforte, M Gustavo Murer, Gregorio L Galiñanes
Repetitive stimulation of cognitive forebrain circuits at frequencies capable of inducing corticostriatal long term plasticity is increasingly being used with therapeutic purposes in patients with neuropsychiatric disorders. However, corticostriatal plasticity is rarely studied in the intact brain. Our aim was to study the mechanisms of corticostriatal long term depression (LTD) induced by high frequency stimulation (HFS) of the medial prefrontal cortex in vivo. Our main finding is that the LTD induced in the dorsomedial striatum by medial prefrontal cortex HFS in vivo (prefrontostriatal LTD) is not affected by manipulations that block or reduce the LTD induced in the dorsolateral striatum by motor cortex HFS in brain slices, including pharmacological dopamine receptor and CB1 receptor blockade, chronic nigrostriatal dopamine depletion, CB1 receptor genetic deletion and selective striatal cholinergic interneuron (SCIN) ablation...
May 2, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28467898/distinct-corticostriatal-gabaergic-neurons-modulate-striatal-output-neurons-and-motor-activity
#15
Sarah Melzer, Mariana Gil, David E Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer
The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM(+)) and parvalbumin-positive (PV(+)) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially...
May 2, 2017: Cell Reports
https://www.readbyqxmd.com/read/28467439/comparison-of-the-spatial-cognitive-functions-of-dorsomedial-striatum-and-anterior-cingulate-cortex-in-mice
#16
Tine Pooters, Annelies Laeremans, Ilse Gantois, Ben Vermaercke, Lutgarde Arckens, Rudi D'Hooge
Neurons in anterior cingulate cortex (aCC) project to dorsomedial striatum (DMS) as part of a corticostriatal circuit with putative roles in learning and other cognitive functions. In the present study, the spatial-cognitive importance of aCC and DMS was assessed in the hidden-platform version of the Morris water maze (MWM). Brain lesion experiments that focused on areas of connectivity between these regions indicated their involvement in spatial cognition. MWM learning curves were markedly delayed in DMS-lesioned mice in the absence of other major functional impairments, whereas there was a more subtle, but still significant influence of aCC lesions...
2017: PloS One
https://www.readbyqxmd.com/read/28462940/chronic-nicotine-alters-corticostriatal-plasticity-in-the-striatopallidal-pathway-mediated-by-nr2b-containing-silent-synapses
#17
Jianxun Xia, Allison M Meyers, Jeff A Beeler
Smoking is the leading cause of preventable death in the United States and success rates for quitting remain low. High relapse rates are attributed to pervasive nicotine-reinforced associative learning of incentive cues that is highly resistant to extinction. Why such learning is so persistent is poorly understood but may arise as a consequence of neuroadaptations in synaptic plasticity induced by chronic nicotine. We used whole-cell patch clamp recording to investigate the effect of chronic nicotine (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium-spiny neurons in the indirect, striatopallidal pathway in dorsolateral striatum...
May 2, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28451710/thalamic-inputs-to-dorsomedial-striatum-are-involved-in-inhibitory-control-evidence-from-the-five-choice-serial-reaction-time-task-in-rats
#18
Jasjot Saund, Daniel Dautan, Claire Rostron, Gonzalo P Urcelay, Todor V Gerdjikov
RATIONALE: Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES: Here, we used designer receptors exclusively activated by designer drugs (DREADDs) to investigate the role of parafascicular (Pf) thalamic inputs to the dorsomedial striatum (DMS) using the five-choice serial reaction time task (5CSRTT) in rats...
April 28, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28449351/long-term-plasticity-of-corticostriatal-synapses-is-modulated-by-pathway-specific-co-release-of-opioids-through-kappa-opioid-receptors
#19
Sarah L Hawes, Armando G Salinas, David M Lovinger, Kim T Blackwell
Synaptic plasticity in striatum adjusts behaviour adaptively during skill learning, or maladaptively in the case of addiction. Just as dopamine plays a critical role in synaptic plasticity underlying normal skill learning and addiction, endogenous and exogenous opiates also modulate learning and addiction-related striatal plasticity. Though the role of opioid receptors in long-term depression in striatum has been characterized, their effect on long-term potentiation (LTP) remains unknown. In particular, direct pathway (Dopamine D1 Receptor containing; D1R) - spiny projection neurons (SPNs) co-release the opioid neuropeptide dynorphin, which acts at presynaptic kappa opioid receptors (KORs) on dopaminergic afferents and can negatively regulate dopamine release...
April 27, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28444823/dissociable-corticostriatal-circuits-underlie-goal-directed-versus-cue-elicited-habitual-food-seeking-after-satiation-evidence-from-a-multimodal-mri-study
#20
Henk van Steenbergen, Poppy Watson, Reinout W Wiers, Bernhard Hommel, Sanne de Wit
The present multimodal MRI study advances our understanding of the corticostriatal circuits underlying goal-directed versus cue-driven, habitual food seeking. To this end, we employed a computerized Pavlovian-instrumental transfer (PIT) paradigm. During the test phase, participants were free to perform learnt instrumental responses (left and right key presses) for popcorn and Smarties outcomes. Importantly, prior to this test half of the participants had been sated on popcorn and the other half on Smarties - resulting in a reduced desirability of those outcomes...
April 26, 2017: European Journal of Neuroscience
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