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https://www.readbyqxmd.com/read/28932321/identification-and-characterization-of-interferon-signaling-related-micrornas-in-occult-hepatitis-b-virus-infection
#1
Yiying Wang, Peifu Zhu, Jing Qiu, Jie Wang, Huijuan Zhu, Yinwei Zhu, Lige Zhang, Jie Zhu, Xingxiang Liu, Chen Dong
BACKGROUND: Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with hepatitis B virus (HBV) infection. However, the characteristics of serum IFN signaling-related miRNAs in OBI remain unclear. Therefore, this study aimed to analyze the expression levels of serum IFN signaling-related miRNAs in OBI and to evaluate their potential values for OBI diagnosis...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28928276/precursor-microrna-122-inhibits-synthesis-of-insig1-isoform-mrna-by-modulating-polyadenylation-site-usage
#2
Kara L Norman, Tzu-Chun Chen, Gusti Zeiner, Peter Sarnow
The insulin-induced gene 1 protein (Insig1) inhibits the cholesterol biosynthesis pathway by retaining transcription factor SREBP in the endoplasmic reticulum, and by causing the degradation of HMGCR, the rate-limiting enzyme in cholesterol biosynthesis. Liver-specific microRNA miR-122, on the other hand, enhances cholesterol biosynthesis by an unknown mechanism. We have found that Insig1 mRNAs are generated by alternative cleavage and polyadenylation, resulting in specific isoform mRNA species. During high cholesterol abundance, the short 1...
September 19, 2017: RNA
https://www.readbyqxmd.com/read/28923593/inducible-microrna-122-modulates-rig-i-signaling-pathway-via-targeting-dak-in-miiuy-croaker-after-poly-i-c-stimulation
#3
Jingjing Han, Qing Chu, Ruixuan Huo, Tianjun Xu
MicroRNA-122 (miR-122) was originally identified in mouse and then lots of researches on miR-122 had been performed in mammals. However, the functional study of miR-122 were restricted in fish. In miiuy croaker, miR-122 is sensitive to poly(I:C) stimulation. In this study, a combination of bioinformatics and experimental techniques were used to investigate the functions of miR-122. DAK is a putative target gene of miR-122 which was predicted by bioinformatics, and further the luciferase reporter assays were used to confirm the target sites in DAK 3'untranslated region...
September 15, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28921581/mir-122-promotes-metastasis-of-clear-cell-renal-cell-carcinoma-by-downregulating-dicer
#4
Yang Fan, Xin Ma, Hongzhao Li, Yu Gao, Qingbo Huang, Yu Zhang, Xu Bao, Qingshan Du, Guoxiong Luo, Kan Liu, Qingyu Meng, Chaofei Zhao, Xu Zhang
Although overall downregulation of microRNAs (miRNAs) is a general feature of clear-cell renal cell carcinoma (ccRCC), several miRNAs are consistently upregulated, among which miR-122 was markedly increased in ccRCC tissues. This study aims to determine the functional importance and underlying mechanism of miR-122 in ccRCC metastasis. Here we demonstrate that the expression of miR-122 increased in ccRCC tissues, and higher miR-122 expression was found in ccRCC tissues with metastatic disease than in those without metastasis...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28890291/mir-122-inhibits-epithelial-mesenchymal-transition-in-hepatocellular-carcinoma-by-targeting-snail1-and-snail2-and-suppressing-wnt-%C3%AE-cadherin-signaling-pathway
#5
Yun Jin, Junfeng Wang, Jiang Han, Ding Luo, Zhiwei Sun
The downregulation of microRNA-122 (miR-122) had been reported to be associated with tumor invasion and metastasis in hepatocellular carcinoma (HCC). However, the underlying mechanisms of miR-122 involved in epithelial-mesenchymal transition (EMT) still need to be investigated. In the study, we demonstrated that miR-122 was significantly downregulated in HCC tissues compared with adjacent normal tissues. MiR-122 expression was closely correlated with tumor size, vascular invasion and American Joint Committee on Cancer (AJCC) stage of HCC patients...
September 8, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28886184/retraction-mir-122-regulates-tumorigenesis-in-hepatocellular-carcinoma-by-targeting-akt3
#6
(no author information available yet)
No abstract text is available yet for this article.
2017: PloS One
https://www.readbyqxmd.com/read/28884294/a-concise-review-of-microrna-exploring-the-insights-of-microrna-regulations-in-bacterial-viral-and-metabolic-diseases
#7
REVIEW
Ahsan Naveed, Sajjad Ur-Rahman, Sabahat Abdullah, Muhammad Ammar Naveed
MicroRNA (miRNA) is a small section of ribonucleic acid (RNA) that reduces the protein formation by making the pair of the complementary piece of mRNA. The genes of miRNA are present as transcriptional or polycistronic units in the chromosomes. The cellular multiplication, separation and existence like the multitude of genetic functions are affected by miRNA. Nearly 50% of identified miRNA are located in the residence in the intronic part of the genes. The mature miRNA is yielded in two steps. Drosha and RNA-induced silencing complex are the catalysts that play an important role in miRNA synthesis...
September 7, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28883647/circulating-mir-122-and-mir-200a-as-biomarkers-for-fatal-liver-disease-in-art-treated-hiv-1-infected-individuals
#8
Daniel D Murray, Kazuo Suzuki, Matthew Law, Jonel Trebicka, Jacquie Neuhaus Nordwall, Margaret Johnson, Michael J Vjecha, Anthony D Kelleher, Sean Emery
Liver disease is one of the main contributors to the increased levels of morbidity and mortality seen in the HIV-1-infected, ART-treated population. Circulating miRNAs, particularly those located inside extracellular vesicles, are seen as promising biomarkers for a number of human disease conditions, including liver-related diseases. Here, we show that serum levels of miR-122 and miR-200a are greater in HIV/HCV co-infected individuals compared to HIV-1 mono-infected individuals. We also show that miR-122 and miR-200a are elevated in ART-treated, HIV-1-infected individuals prior to the development of fatal liver disease, suggesting that these miRNA may have some potential clinical utility as biomarkers...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871076/knockdown-of-microrna-122-protects-h9c2-cardiomyocytes-from-hypoxia-induced-apoptosis-and-promotes-autophagy
#9
Zaiwei Zhang, Hu Li, Shasha Chen, Ying Li, Zhiyuan Cui, Jie Ma
BACKGROUND Acute myocardial infarction (AMI) is a severe disease causing heart failure and sudden death. Studies indicate that microRNAs (miRNAs) are involved in the pathophysiology of AMI. In the present study, we carefully explored the effects of miR-122 on myocardial hypoxia injury and its possible underlying mechanism. MATERIAL AND METHODS miR-122 expression was analyzed in H9c2 cardiomyocytes after being transfected with miR-122 mimic, ASO-miR-122, or negative control. Cell viability and apoptosis were investigated by CCK-8 assays and flow cytometry analysis, respectively...
September 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28864835/neat1-accelerates-the-progression-of-liver-fibrosis-via-regulation-of-microrna-122-and-kruppel-like-factor-6
#10
Fujun Yu, Zhe Jiang, Bicheng Chen, Peihong Dong, Jianjian Zheng
Long non-coding RNAs (lncRNAs) have been reported to be involved in many important biological processes including proliferation, apoptosis, differentiation, and survival. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1), a novel lncRNA, serves as a crucial regulator in tumors. However, the biological role of NEAT1 in liver fibrosis is largely unknown. In this study, the role of NEAT1 was explored in primary mouse hepatic stellate cells (HSCs) and carbon tetrachloride (CCl4)-induced mouse liver fibrosis models...
September 1, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28864162/treatment-induced-viral-cure-of-hepatitis-c-virus-infected-patients-involves-a-dynamic-interplay-among-three-important-molecular-players-in-lipid-homeostasis-circulating-microrna-mir-24-mir-223-and-proprotein-convertase-subtilisin-kexin-type-9
#11
Anastasia Hyrina, Andrea D Olmstead, Paul Steven, Mel Krajden, Edward Tam, François Jean
In patients with chronic hepatitis C virus (HCV) infection, viral hijacking of the host-cell biosynthetic pathways is associated with altered lipid metabolism, which contributes to disease progression and may influence antiviral response. We investigated the molecular interplay among four key regulators of lipid homeostasis [microRNA (miR)-122, miR-24, miR-223, and proprotein convertase subtilisin/kexin type 9 (PCSK9)] in HCV-infected patients (n=72) who achieved a treatment-based viral cure after interferon-based therapy with first-generation direct-acting antivirals...
September 2017: EBioMedicine
https://www.readbyqxmd.com/read/28859226/viral-persistence-liver-disease-and-host-response-in-hepatitis-c-like-virus-rat-model
#12
Sheetal Trivedi, Satyapramod Murthy, Himanshu Sharma, Alex S Hartlage, Arvind Kumar, Sashi Gadi, Peter Simmonds, Lokendra V Chauhan, Troels K H Scheel, Eva Billerbeck, Peter D Burbelo, Charles M Rice, W Ian Lipkin, Kurt Vandergrift, John M Cullen, Amit Kapoor
The lack of a relevant, tractable, and immunocompetent animal model for hepatitis C virus (HCV) has severely impeded investigations of viral persistence, immunity and pathogenesis. In the absence of immunocompetent models with robust HCV infection, homolog hepaciviruses in their natural host could potentially provide useful surrogate models. We isolated a rodent hepacivirus (RHV) from wild rats (Rattus norvegicus), RHV-rn1, acquired the complete viral genome sequence and developed an infectious reverse genetics system...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28844749/immune-responses-in-daa-treated-chronic-hepatitis-c-patients-with-and-without-prior-rg-101-dosing
#13
Meike H van der Ree, Femke Stelma, Sophie B Willemse, Anthony Brown, Leo Swadling, Marc van der Valk, Marjan J Sinnige, Ad C van Nuenen, J Marleen L de Vree, Paul Klenerman, Eleanor Barnes, Neeltje A Kootstra, Hendrik W Reesink
BACKGROUND&AIMS: With the introduction of DAA's, the majority of treated chronic hepatitis C patients (CHC) achieve a viral cure. The exact mechanisms by which the virus is cleared after successful therapy, is still unknown. The aim was to assess the role of the immune system and miRNA levels in acquiring a sustained virological response after DAA treatment in CHC patients with and without prior RG-101 (anti-miR-122) dosing. METHODS: In this multicenter, investigator-initiated study, 29 patients with hepatitis C virus (HCV) genotype 1 (n = 11), 3 (n = 17), or 4 (n = 1) infection were treated with sofosbuvir and daclatasvir ± ribavirin...
August 24, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28844483/serum-microrna-122-3p-microrna-194-5p-and-microrna-5099-are-potential-toxicological-biomarkers-for-the-hepatotoxicity-induced-by-airpotato-yam
#14
Rui Yang, Fan Yang, Zhenlin Huang, Yao Jin, Yuchen Sheng, Lili Ji
Airpotato yam (the rhizome of Dioscorea bulbifera L.) is traditionally used to treat thyroid disease and various cancers in China. However, it was found to cause hepatotoxicity during clinical practice. This study aims to identify candidate serum microRNAs (miRNAs) as diagnostic biomarkers for the liver injury induced by Airpotato yam. The results of serum alanine/aspartate aminotransferase (ALT/AST) showed the remarkable hepatotoxicity induced by ethyl acetate fraction of Airpotato yam (EF) (450mg/kg) and diosbulbin B (DB) (300mg/kg) in mice...
August 24, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28834611/a-molecular-method-to-detect-wound-cells-in-bloodstains-resultant-of-sharp-force-injuries-for-crime-scene-reconstruction
#15
Donald J Johnson, David E Raymond, Cynthia Chen, Matthew Quon, Julian Lis, Mo Re Choi, Christopher Lopez, Aileen Han, Ray D de Leon, Cynthia Bir
Previous research by the authors on an animal model showed that bloodstains can contain additional information about their somatic origin in the form of wound cells. Bloodstains produced by a gunshot wound to the head were distinguished from bloodstains produced by a gunshot wound to the chest by testing the stains for a brain microRNA marker. In this study, the effectiveness of the technique was examined on blood drops shed externally from a stab wound to the liver of rat carcasses. Specifically, investigations were conducted on the liver microRNA marker, rno-mir-122-3p, with the QIAGEN miScript System, and PCR analysis...
August 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28834285/mirna-signatures-of-insulin-resistance-in-obesity
#16
Angela Jones, Kirsty M Danielson, Miles C Benton, Olivia Ziegler, Ravi Shah, Richard S Stubbs, Saumya Das, Donia Macartney-Coxson
OBJECTIVE: Extracellular microRNAs (miRNAs) represent functional biomarkers for obesity and related disorders; this study investigated plasma miRNAs in insulin resistance phenotypes in obesity. METHODS: One hundred seventy-five miRNAs were analyzed in females with obesity (insulin sensitivity, n = 11; insulin resistance, n = 19; type 2 diabetes, n = 15) and without obesity (n = 12). Correlations between miRNA level and clinical parameters and levels of 15 miRNAs in a murine obesity model were investigated...
August 21, 2017: Obesity
https://www.readbyqxmd.com/read/28832247/mirna-profiling-for-diagnosis-prognosis-and-stratification-of-cancer-treatment-in-cholangiocarcinoma
#17
Jisce R Puik, Laura L Meijer, Tessa Ys Le Large, Mireia Mato Prado, Adam E Frampton, Geert Kazemier, Elisa Giovannetti
Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tract epithelium. Most patients are diagnosed at an advanced stage. Even after resection with curative intent, prognosis remains poor. Previous studies have reported the evolving role of miRNAs as novel biomarkers in cancer diagnosis, prognostication and chemotherapy response. Various miRNAs, such as miR-21, miR-26, miR-122 and miR-150, have been identified as possible blood-based biomarkers for noninvasive diagnosis of CCA. Moreover, epithelial-mesenchymal transition (EMT)- and angiogenesis-associated miRNAs have been implicated in tumor cell dissemination and are able to determine clinical outcome...
August 23, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28822593/decreased-expression-of-microrna-122-is-associated-with-an-unfavorable-prognosis-in-childhood-acute-myeloid-leukemia-and-function-analysis-indicates-a-therapeutic-potential
#18
Juan Yang, Yufang Yuan, Xiaochun Yang, Ze Hong, Lijuan Yang
MicroRNA (miR)-122 functions as a tumor suppressor in various human cancers. However, its involvement in childhood acute myeloid leukemia (AML) remains unknown. In this study, quantitative real-time PCR assay demonstrated that miR-122 expression in bone marrow specimens from AML children were significantly lower than that in non-malignant controls (P<0.001). Statistically, AML children with low miR-122 expression more frequently had large white blood cell count (P=0.022), French-American-British classification subtype M7 (P<0...
June 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28819446/incremental-value-of-circulating-mir-122-5p-to-predict-outcome-after-out-of-hospital-cardiac-arrest
#19
Yvan Devaux, Antonio Salgado-Somoza, Josef Dankiewicz, Adeline Boileau, Pascal Stammet, Anna Schritz, Lu Zhang, Mélanie Vausort, Patrik Gilje, David Erlinge, Christian Hassager, Matthew P Wise, Michael Kuiper, Hans Friberg, Niklas Nielsen
Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arrest. Methods. We analyzed 590 patients from the Targeted Temperature Management trial (TTM-trial). Circulating levels of miR-122-5p were measured in serum samples obtained 48 hours after return of spontaneous circulation...
2017: Theranostics
https://www.readbyqxmd.com/read/28792091/the-combination-of-mir-122-overexpression-and-let-7f-silencing-induces-hepatic-differentiation-of-adipose-tissue-derived-stem-cells
#20
Nahid Davoodian, Abbas S Lotfi, Masoud Soleimani, Hori Ghaneialvar
Human adipose tissue-derived stem cells (hADSCs) have been considered as a promising source for cell therapy of liver diseases due to their accessibility, abundance, and expression of hepatocyte markers. Currently, the important role of certain microRNAs (miRNAs) has been reported during hepatic differentiation of stem cells. However, the combination effect of miRNAs on hepatic differentiation of these cells needs to be more investigated. The present study seeks to determine whether the combination of miRNAs can enhance hepatic differentiation of hADSCs in the absence of any other stimulation...
August 9, 2017: Cell Biology International
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