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https://www.readbyqxmd.com/read/28521446/candidate-mirnas-and-pathogenesis-investigation-for-hepatocellular-carcinoma-based-on-bioinformatics-analysis
#1
Wenbin Ding, Haixia Yang, Shenchu Gong, Weixiang Shi, Jing Xiao, Jinhua Gu, Yilang Wang, Bosheng He
The present study aimed to explore the mechanisms behind the development and progression of hepatocellular carcinoma (HCC) and identify information regarding HCC-related microRNAs (miRNAs) or marker genes for the gene therapy of HCC. Gene expression profile of GSE67882, generated from 4 hepatitis B virus infected HCC tissue samples (HCC group) and 8 chronic hepatitis B tissue samples with no fibrosis (control group) were downloaded from the Gene Expression Omnibus database. The differentially expressed miRNAs functional enrichment and pathway analyses of HCC were revealed, followed by transcription factor-miRNA interaction network construction and analyses...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521302/hepatitis-b-virus-x-protein-induced-upregulation-of-cat-1-stimulates-proliferation-and-inhibits-apoptosis-in-hepatocellular-carcinoma-cells
#2
Rongjuan Dai, Feng Peng, Xinqiang Xiao, Xing Gong, Yongfang Jiang, Min Zhang, Yi Tian, Yun Xu, Jing Ma, Mingming Li, Yue Luo, Guozhong Gong
The HBx protein of hepatitis B virus (HBV) is widely recognized to be a critical oncoprotein contributing to the development of HBV-related hepatocellular carcinoma (HCC). In addition, cationic amino acid transporter 1 (CAT-1) gene is a target of miR-122. In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis. Moreover, HBx-induced decreases in Gld2 and miR-122 levels that contributed to the upregulation of CAT-1 in HCC...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512857/interest-of-variations-in-mir-152-and-mir-122-in-a-series-of-hepatocellular-carcinomas-related-to-hcv-infection
#3
Elodie Miquelestorena-Standley, Anne Tallet, Christine Collin, Eric Piver, Anne De Muret, Ephrem Salamé, Pascal Bourlier, Thibault Kervarrec, Serge Guyétant, Jean-Christophe Pagès
AIM: Hepatocellular carcinoma (HCC) is a common outcome of chronic hepatitis C virus (HCV) infection and constitutes the main burden of this disease. The molecular mechanisms underlying the development of HCC are multiple and might involve certain microRNA (miR). Since discordant results have been reported concerning the detection of expression of miR-152 and miR-122 in HCC, our aim was to measure the levels of both miRs in serum and liver samples. METHODS: We analyzed miR-152 and miR-122 expression by RT-qPCR in a serum cohort from 14 HCV-infected patients who developed HCC, 20 HCV+ patients without HCC and 19 control patients...
May 17, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28496005/circulating-plasma-micrornas-as-potential-markers-to-identify-egfr-mutation-status-and-to-monitor-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-treatment-in-patients-with-advanced-non-small-cell-lung-cancer
#4
Lili Qu, Liangliang Li, Xiaofei Zheng, Hanjiang Fu, Chuanhao Tang, Haifeng Qin, Xiaoyan Li, Hong Wang, Jianjie Li, Weixia Wang, Shaoxing Yang, Lin Wang, Guanhua Zhao, Panpan Lv, Yangyang Lei, Min Zhang, Hongjun Gao, Santai Song, Xiaoqing Liu
We aimed to identify a panel of circulating plasma microRNAs that can predict EGFR mutation status and monitor epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with non-small cell lung cancer. Microarrays were performed for the preliminary screening of dysregulated microRNAs in 9 EGFR mutation-positive patients versus healthy controls. MiR-107 was upregulated and miR-195 was downregulated in the exon 19 deletion versus wild-type group. The areas under the receiver operating characteristic curves for miR-107, miR-195, and a panel of these 2 microRNAs were 0...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28494029/characterization-of-mir-122-independent-propagation-of-hcv
#5
Chikako Ono, Takasuke Fukuhara, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Satomi Yamamoto, Tomokazu Tamura, Hiroyuki Mori, Asuka Sato, Kentaro Uemura, Yuzy Fauzyah, Takeshi Kurihara, Takahiro Suda, Akira Nishio, Su Su Hmwe, Toru Okamoto, Tomohide Tatsumi, Tetsuo Takehara, Kazuaki Chayama, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura
miR-122, a liver-specific microRNA, is one of the determinants for liver tropism of hepatitis C virus (HCV) infection. Although miR-122 is required for efficient propagation of HCV, we have previously shown that HCV replicates at a low rate in miR-122-deficient cells, suggesting that HCV-RNA is capable of propagating in an miR-122-independent manner. We herein investigated the roles of miR-122 in both the replication of HCV-RNA and the production of infectious particles by using miR-122-knockout Huh7 (Huh7-122KO) cells...
May 11, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28485676/assessment-of-preclinical-liver-and-skeletal-muscle-biomarkers-following-clofibrate-administration-in-wistar-rats
#6
Pierre Maliver, Matthias Festag, Moritz Bennecke, Francois Christen, Balázs Bánfai, Barbara Lenz, Michael Winter
Clofibrate is a known rodent hepatotoxicant classically associated with hepatocellular hypertrophy and increased serum activities of cellular alanine aminotransferase/aspartate aminotransferase (ALT/AST) in the absence of microscopic hepatocellular degeneration. At toxic dose, clofibrate induces liver and skeletal muscle injury. The objective of this study was to assess novel liver and skeletal muscle biomarkers following clofibrate administration in Wistar rats at different dose levels for 7 days. In addition to classical biomarkers, liver injury was assessed by cytokeratin 18 (CK18) cleaved form, high-mobility group box 1, arginase 1 (ARG1), microRNA 122 (miR-122), and glutamate dehydrogenase...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28475652/serum-microrna-122-and-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-are-useful-tools-for-liquid-biopsy-of-the-patients-with-hepatitis-b-virus-and-advanced-liver-fibrosis
#7
Masato Nakamura, Tatsuo Kanda, Xia Jiang, Yuki Haga, Koji Takahashi, Shuang Wu, Shin Yasui, Shingo Nakamoto, Osamu Yokosuka
BACKGROUND: Noninvasive methods to accurately and conveniently evaluate liver fibrosis are desirable. MicroRNA (miR) is one of the candidates. MiRs are small RNAs consisting of 19-25 nucleotides that negatively regulate many target genes at transcriptional levels. Recently, many researchers have focused on circulating miRs in the blood stream as biomarkers. Hepatic miR-122 has been reported to have an association with viral replication and hepatic fibrosis in chronic hepatitis B virus (HBV) and hepatic C virus (HCV) infection...
2017: PloS One
https://www.readbyqxmd.com/read/28460582/comprehensive-analysis-of-circulating-microrna-specific-to-the-liver-heart-and-skeletal-muscle-of-cynomolgus-monkeys
#8
Takuma Iguchi, Noriyo Niino, Satoshi Tamai, Ken Sakurai, Kazuhiko Mori
Circulating microRNAs (miRNAs) could represent sensitive and specific biomarkers for tissue injury. However, their utility as biomarkers in nonclinical toxicological studies using nonhuman primates is limited by a lack of information on their organ specificity and circulating levels under resting condition of the animals. Herein, liver, heart, and skeletal muscle-specific expression patterns of miRNAs were determined in 27 tissues/organs from male and female monkeys (n =2/sex) by next-generation sequencing (NGS) analysis...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28456022/cellular-dead-box-rna-helicase-ddx6-modulates-interaction-of-mir-122-with-the-5-untranslated-region-of-hepatitis-c-virus-rna
#9
Jason M Biegel, Eric Henderson, Erica M Cox, Gaston Bonenfant, Rachel Netzband, Samantha Kahn, Rachel Eager, Cara T Pager
Hepatitis C virus (HCV) subverts the cellular DEAD-box RNA helicase DDX6 to promote virus infection. Using polysome gradient analysis and the subgenomic HCV Renilla reporter replicon genome, we determined that DDX6 does not affect HCV translation. Rather expression of the subgenomic HCV Renilla luciferase reporter at late times, as well as labeling of newly synthesized viral RNA with 4-thiouridine showed that DDX6 modulates replication. Because DDX6 is an effector protein of the microRNA pathway, we also investigated its role in miR-122-directed HCV gene expression...
April 26, 2017: Virology
https://www.readbyqxmd.com/read/28455143/ire1%C3%AE-links-nck1-deficiency-to-attenuated-ptp1b-expression-in-hepg2-cells
#10
Hui Li, Bing Li, Louise Larose
PTP1B, a prototype of the non-receptor subfamily of the protein tyrosine phosphatase superfamily, plays a key role in regulating intracellular signaling from various receptor and non-receptor protein tyrosine kinases. Previously, we reported that silencing Nck1 in human hepatocellular carcinoma HepG2 cells enhances basal and growth factor-induced activation of the PI3K-Akt pathway through attenuating PTP1B expression. However, the underlying mechanism by which Nck1 depletion represses PTP1B expression remains unclear...
April 25, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28454305/microrna-profile-of-hepatic-epithelioid-hemangioendothelioma-a-case-report
#11
Asahiro Morishita, Hisakazu Iwama, Hirohito Yoneyama, Teppei Sakamoto, Koji Fujita, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Shintaro Fujihara, Noriko Nishiyama, Hideki Kobara, Hirohito Mori, Naoki Yamamoto, Keiichi Okano, Yasuyuki Suzuki, Emi Ibuki, Reiji Haba, Takashi Himoto, Tsutomu Masaki
A 72-year-old female was referred for further evaluation of epigastralgia. Abdominal contrast computed tomography revealed numerous tumors in the two lobes of the liver. Liver biopsy and immunohistochemical staining revealed that the tumor cells were positive for factor VIII-associated antigen, platelet endothelial cell adhesion molecule 1 and human hematopoietic progenitor cell antigen, concordant with a diagnosis of hepatic epithelioid hemangioendothelioma (HEH). To elucidate the etiology of HEH, particularly the microRNA (miRNA) profiles, tissue samples obtained from normal and tumor tissues were analyzed using a miRNA array system...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451447/dynamic-changes-of-serum-microrna-122-5p-through-therapeutic-courses-indicates-amelioration-of-acute-liver-injury-accompanied-by-acute-cardiac-decompensation
#12
Satoshi Koyama, Takashi Kuragaichi, Yukihito Sato, Yasuhide Kuwabara, Shunsuke Usami, Takahiro Horie, Osamu Baba, Daihiko Hakuno, Yasuhiro Nakashima, Tomohiro Nishino, Masataka Nishiga, Tetsushi Nakao, Hidenori Arai, Takeshi Kimura, Koh Ono
AIMS: Recent studies have shown that serum microRNA (miR) abundance is informative for the diagnosis or prognosis of heart failure. However, the dynamics and kinetics of miRs in acute heart failure are largely unknown. Serial measurement and analysis of serum miRs changes in individuals along their therapeutic course could reduce inter-individual variation and should detect potentially important serum miRs related to disease mechanisms. Based on this concept, we profiled serum miR signatures of blood samples that were obtained sequentially on the day of admission and on hospital Day 7...
May 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28442604/hepatitis-c-virus-indirectly-disrupts-dna-damage-induced-p53-responses-by-activating-protein-kinase-r
#13
Jonathan K Mitchell, Bentley R Midkiff, Benjamin Israelow, Matthew J Evans, Robert E Lanford, Christopher M Walker, Stanley M Lemon, David R McGivern
Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of liver cancer in many regions of the world. Here we show that HCV-permissive, liver-derived HepG2 cells engineered to constitutively express microRNA-122 (HepG2/miR-122 cells) have normal p53-mediated responses to DNA damage and that HCV replication in these cells potently suppresses p53 responses to etoposide, an inducer of DNA damage, or nutlin-3, an inhibitor of p53 degradation pathways...
April 25, 2017: MBio
https://www.readbyqxmd.com/read/28421107/sexual-dimorphism-of-mirnas-secreted-by-bovine-in-vitro-produced-embryos
#14
Nicole Gross, Jenna Kropp, Hasan Khatib
Sexual dimorphism of bovine blastocysts has previously been observed through differences in development, cell death, metabolism, telomere length, DNA methylation, and transcriptomics. However, dimorphism in the secretion of miRNAs to culture media has not yet been evaluated. The objectives of this study were to determine if sex-specific blastocyst miRNA secretion occurs and to further investigate the role these miRNAs may have in the interaction between a blastocyst and the maternal environment. In vitro embryo culture was performed and media from male and female blastocysts was collected into sex-specific pools...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28412211/serum-mir-21-and-mir-125b-as-markers-predicting-neoadjuvant-chemotherapy-response-and-prognosis-in-stage-ii-iii-breast-cancer
#15
Baoquan Liu, Fei Su, Mingwei Chen, Yue Li, Xiuying Qi, Jianbing Xiao, Xuemei Li, Xiangchen Liu, Wenlong Liang, Yafang Zhang, Jianguo Zhang
The predictive value of serum miRNAs (ser-miRNA) for the response to neoadjuvant chemotherapy (NCT) and the prognosis of breast cancer patients was investigated in the current study. The study included 118 stage II/III breast cancer patients and 30 healthy adult women. Peripheral blood was drawn from participants before the start (baseline, BL), at the end of the second cycle (first evaluation during NCT, FEN), and at the end of NCT (second evaluation during NCT, SEN). The expression of ser-miRNAs was examined by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and their association with chemotherapy response and prognosis was analyzed...
April 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28411393/global-exosome-transcriptome-profiling-reveals-biomarkers-for-multiple-sclerosis
#16
Igor Selmaj, Maria Cichalewska, Magdalena Namiecinska, Grazyna Galazka, Wojciech Horzelski, Krzysztof W Selmaj, Marcin P Mycko
OBJECTIVE: Accumulating evidence supports a role for exosomes in immune regulation. In this study, we investigated the total circulating exosome transcriptome in relapsing-remitting multiple sclerosis patients (RRMS) and healthy controls (HC). METHODS: Next generation sequencing (NGS) was used to define the global RNA profile of serum exosomes in 19 RRMS patients (9 in relapse, 10 in remission) and 10 HC. We analyzed 5 million reads and over 50,000 transcripts per sample, including a detailed analysis of microRNA (miRNA) differentially expressed in RRMS...
April 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28401565/serum-and-exosomal-mir-122-and-mir-199a-as-a-biomarker-to-predict-therapeutic-efficacy-of-hepatitis-c-patients
#17
Xiaoyang Jiao, Zhicheng Fan, Huanzhu Chen, Ping He, Yazhen Li, Qiaoxin Zhang, Changwen Ke
AIM: MicroRNA (miRNA), which has been shown to correlate with liver functions, has been proposed as a new biomarker reflecting liver injury. The aim of the study was to investigate miRNA -122 (miR-122) and mir-RNA -199a (miR-199a) as a biomarker for predicting therapeutic efficacy in hepatitis C (HepC)patients. METHODS: 47 HepC 1b patients and 16 healthy subjects were enrolled in the study. Serum and exosomal mir-RNAs and other conventional biomarkers reflecting liver function were evaluated...
April 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28399937/specific-circulating-microrna-signature-of-bicuspid-aortic-valve-disease
#18
Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges, Josep M Alegret
BACKGROUND: We aimed to determine the circulating miRNA expression profile associated with BAV and aortic dilation to provide diagnostic and prognostic biomarkers for BAV and/or aortic dilation. METHODS AND RESULTS: We applied a miRNome-wide microarray approach using plasma samples (n = 24) from healthy tricuspid aortic valve individuals, BAV patients and BAV patients with aortic dilation to compare and identify the specific miRNAs associated with BAV and aortic dilation...
April 11, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28397375/elevation-of-circulating-microrna-levels-in-obese-children-compared-to-healthy-controls
#19
M D Thompson, M J Cismowski, M Serpico, A Pusateri, D R Brigstock
As childhood obesity increases, it is becoming important to understand the complications of obesity in children and develop novel biomarkers. Evidence indicates that microRNAs (miRNA) are dys-regulated in obesity and may serve as sensitive and specific circulating biomarkers. Non-alcoholic fatty liver disease (NAFLD) is a complication of obesity that ultimately requires a liver biopsy to determine disease severity. While studies have been conducted in adults, no study to date has examined circulating miRNAs in children with obesity and NAFLD...
April 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28397307/genetic-variants-in-micrornas-and-their-binding-sites-within-gene-3-utrs-associate-with-susceptibility-to-age-related-macular-degeneration
#20
Mohsen Ghanbari, Stefan J Erkeland, Lei Xu, Johanna M Colijn, Oscar H Franco, Abbas Dehghan, Caroline C W Klaver, Magda A Meester-Smoor
Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease that results from multiple genetic and environmental factors. MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate target mRNAs and are frequently implicated in human diseases. Here, we investigated the association of genetic variants in miRNAs and miRNA-binding sites within gene 3'-untranslated regions (3'UTRs) with AMD using data from the largest AMD genome-wide association study...
April 10, 2017: Human Mutation
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