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https://www.readbyqxmd.com/read/29135813/pendular-seesaw-nystagmus-in-a-patient-with-a-giant-pituitary-macroadenoma-pathophysiology-and-the-role-of-the-accessory-optic-system
#1
Peter Yat-Ming Woo, Saori Takemura, Allen Ming-Yan Cheong, Alberto Chi-Ho Chu, Yung Chan, Hoi-Tung Wong, Kwong-Yau Chan
Seesaw nystagmus is characterized by cyclic eye movements with a conjugate torsional component and a dissociated vertical component. In the first half of the cycle, one eye elevates and intorts, whereas the other eye depresses and extorts. The pattern is reversed in the remaining half of the cycle. We describe a patient with a giant pituitary adenoma who developed pendular seesaw nystagmus. Disturbance in the visuovestibular system is postulated to contribute to this form of seesaw nystagmus. Lesions compressing the optic chiasm and the accessory optic system could interrupt the transmission of retinal error signals to the inferior olivary nucleus and the interstitial nucleus of Cajal, thus interfering with the adaptive mechanism of the vestibulo-ocular reflex and leading to pendular seesaw nystagmus...
November 9, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29117664/pituitary-abscess-with-unusual-clinical-course
#2
Milica Medić Stojanoska, Duško Kozić, Mladen Bjelan, Petar Vuleković, Nada Vučković, Bojan Vuković, Branka Kovačev Zavišić
The aim is to present unusual clinical course and magnetic resonance imaging (MRI) features of pituitary abscess. A 59-year-old man presented with fever, polyuria, polydipsia and marked weight loss within the last two months. Basic endocrinology tests revealed the presence of anterior pituitary dysfunction, associated with central diabetes insipidus and increased levels of inflammatory markers. The presence of expansile sellar lesion, showing restricted diffusion signal pattern compatible with acute pituitary pyogenic abscess was found on MRI...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29116483/pittsburgh-compound-b-pib-pet-imaging-of-meningioma-and-other-intracranial-tumors
#3
Derek R Johnson, Christopher H Hunt, Mark A Nathan, Joseph E Parisi, Bradley F Boeve, Melissa E Murray, David S Knopman, Clifford R Jack, Ronald C Petersen, Val J Lowe, Geoffrey B Johnson
Meningiomas are the most common intracranial tumors. Diagnosis by MRI is generally straightforward, but lack of imaging specificity can present a diagnostic dilemma, particularly in patients with cancer. We report our experience with meningioma identification on Pittsburgh compound B (PiB) PET/CT. Patients who underwent PiB PET/CT from 2006 to 2015 were reviewed to identify those with intracranial tumors. Tumor types were classified by MR appearance, or by pathology when available. Maximum standardized uptake value (SUVmax) measurements of tumor PiB activity were compared across tumor types...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29076785/early-versus-late-gamma-knife-radiosurgery-following-transsphenoidal-surgery-for-nonfunctioning-pituitary-macroadenomas-a-multicenter-matched-cohort-study
#4
I Jonathan Pomeraniec, Hideyuki Kano, Zhiyuan Xu, Brandon Nguyen, Zaid A Siddiqui, Danilo Silva, Mayur Sharma, Hesham Radwan, Jonathan A Cohen, Robert F Dallapiazza, Christian Iorio-Morin, Amparo Wolf, John A Jane, Inga S Grills, David Mathieu, Douglas Kondziolka, Cheng-Chia Lee, Chih-Chun Wu, Christopher P Cifarelli, Tomas Chytka, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Gamma Knife radiosurgery (GKRS) is frequently used to treat residual or recurrent nonfunctioning pituitary macroadenomas. There is no consensus as to whether GKRS should be used early after surgery or if radiosurgery should be withheld until there is evidence of imaging-defined progression of tumor. Given the high incidence of adenoma progression after subtotal resection over time, the present study intended to evaluate the effect of timing of radiosurgery on outcome. METHODS This is a multicenter retrospective review of patients with nonfunctioning pituitary macroadenomas who underwent transsphenoidal surgery followed by GKRS from 1987 to 2015 at 9 institutions affiliated with the International Gamma Knife Research Foundation...
October 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29074612/aip-mutations-in-brazilian-patients-with-sporadic-pituitary-adenomas-a-single-center-evaluation
#5
Paula Bruna Araujo, Leandro Kasuki, Carlos Henrique de Azeredo Lima, Liana Lumi Ogino, Aline H S Camacho, Leila Chimelli, Marta Korbonits, Monica R Gadelha
Aryl hydrocarbon receptor-interacting protein (AIP) gene mutations (AIPmut) are the most frequent germline mutations found in apparently sporadic pituitary adenomas (SPA). Our aim was to evaluate the frequency of AIPmut among young Brazilian patients with SPA. We performed an observational cohort study between 2013-2016 in a single referral center. AIPmut screening was carried out in 132 SPA patients with macroadenomas diagnosed up to 40 years, or in adenomas of any size diagnosed until 18 years of age. Twelve tumor samples were also analyzed...
October 26, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29066490/novel-germline-p-gly42val-men1-mutation-in-a-family-with-multiple-endocrine-neoplasia-type-1-excellent-response-of-prolactinoma-to-cabergoline
#6
Viktoria F Koehler, Kerstin Jungheim, Ute Groß, Donato Iacovazzo, Alexander Mann, Márta Korbonits
We report on a 27-year-old male patient presenting with renal colic secondary to hyperparathyroidism. Further investigations confirmed a diagnosis of type 1 multiple endocrine neoplasia and revealed a 2.0 cm pancreatic neuroendocrine tumour as well as a pituitary macroadenoma with significantly elevated prolactin levels. The patient underwent three-gland parathyroidectomy, a left pancreatectomy, and received dopamine agonist treatment. Genetic testing revealed a novel germline heterozygote missense mutation in the MEN1 gene (p...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29063272/the-learning-curve-for-endoscopic-trans-sphenoidal-resection-of-pituitary-macroadenomas-a-single-institution-experience-leeds-uk
#7
James M W Robins, Seyed A Alavi, Atul K Tyagi, Paul A Nix, Tom M Wilson, Nick I Phillips
BACKGROUND: The object of this study was to assess whether increasing operative experience results in greater endoscopic trans-sphenoidal resection of pituitary macroadenomas and lower complications. METHODS: A retrospective single institution cohort study was performed. Subjects underwent endoscopic trans-sphenoidal resection of pituitary macroadenoma between July 2009 and July 2016 by three neurosurgeons. Following data collection, statistical analysis compared percentage of tumor resection and length of hospital stay (LOS) with experience...
October 23, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29032531/bilateral-tolosa-hunt-syndrome-mimicking-pituitary-adenoma
#8
Renata Świątkowska-Stodulska, Dominik Stodulski, Anna Babińska, Maciej Piskunowicz, Krzysztof Sworczak
The authors report a rare case of bilateral Tolosa-Hunt syndrome, which occurred in a 80-year-old female and remitted spontaneously. Inflammatory lesions were found not only in typical locations, i.e. superior orbital fissures and cavernous sinuses, but also in the pituitary; these imitated gland's macroadenoma in imaging studies.
October 14, 2017: Endocrine
https://www.readbyqxmd.com/read/29031329/dogs-with-macroadenomas-have-lower-body-temperature-and-heart-rate-than-dogs-with-microadenomas
#9
Ghita Benchekroun, Loic Desquilbet, Michael E Herrtage, Nick D Jeffery, Dan Rosenberg, Nicolas Granger
Pituitary macroadenomas compress the hypothalamus, which partly regulates heart rate and body temperature. The aim of this study was to investigate whether heart rate and/or body temperature could aid in clinically differentiating dogs with macroadenomas from dogs with microadenomas (i.e. small non-compressive pituitary mass). Two groups of dogs diagnosed with pituitary-dependent hyperadrenocorticism (i.e. Cushing's disease) were included. Heart rate and body temperature were collected on initial presentation before any procedure...
September 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29027863/potential-utility-of-flair-in-mri-negative-cushing-s-disease
#10
Grégoire P Chatain, Nicholas Patronas, James G Smirniotopoulos, Martin Piazza, Sarah Benzo, Abhik Ray-Chaudhury, Susmeeta Sharma, Maya Lodish, Lynnette Nieman, Constantine A Stratakis, Prashant Chittiboina
OBJECTIVE Accurate presurgical localization of microadenomas in Cushing's disease (CD) leads to improved remission rates and decreased adverse events. Volumetric gradient recalled echo (3D-GRE) MRI detects pituitary microadenomas in CD in up to 50%-80% cases as a focus of hypointensity due to delayed contrast wash-in. The authors have previously reported that postcontrast FLAIR imaging may be useful in detecting otherwise MRI-negative pituitary microadenomas as foci of hyperintensity. This reflects theoretically complementary imaging of microadenomas due to delayed contrast washout...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027854/long-term-outcomes-of-tissue-based-acth-antibody-assay-guided-transsphenoidal-resection-of-pituitary-adenomas-in-cushing-disease
#11
J Mark Erfe, Avital Perry, John McClaskey, Silvio E Inzucchi, Whitney Sheen James, Tore Eid, Richard A Bronen, Amit Mahajan, Anita Huttner, Florecita Santos, Dennis Spencer
OBJECTIVE Cushing disease is caused by a pituitary micro- or macroadenoma that hypersecretes adrenocorticotropic hormone (ACTH), resulting in hypercortisolemia. For decades, transsphenoidal resection (TSR) has been an efficacious treatment but with certain limitations, namely precise tumor localization and complete excision. The authors evaluated the novel use of a double-antibody sandwich assay for the real-time quantitation of ACTH in resected pituitary specimens with the goals of augmenting pathological diagnosis and ultimately improving long-term patient outcome...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#12
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29022641/-familial-isolated-pituitary-adenomas-fipa-case-report-of-four-families-and-review-of-literature
#13
Joanna Elżbieta Malicka, Joanna Świrska, Maria Kurowska, Marta Dudzińska, Jerzy S Tarach
BackgroundThe majority of pituitary adenomas are sporadic, but about 5% of them occur in a familial setting, predominantly in multiple endocrine neoplasia type 1 and Carney complex. Familial isolated pituitary adenomas (FIPA), unrelated to the syndromes mentioned above, were also described. The clinical course of FIPA differs significantly from sporadic cases, and is characterized by a larger tumor size, more aggressive course and younger patients' age at the moment of recognition. ObjectivesThe aim of this retrospective study is to present 4 families in which two closely related people were diagnosed with pituitary adenomas...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022276/diagnosis-and-treatment-of-tsh-secreting-adenomas-review-of-a-longtime-experience-in-a-reference-center
#14
D M Nazato, J Abucham
PURPOSE: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. METHODS: A series of 11 patients with TSH-secreting and cosecreting adenomas diagnosed and treated in the last 25 years in a single center is described. RESULTS: The mean age at diagnosis was 37 years (range 18-80 years; median 23 years); the ratio of male-to-female patients was similar (6M:5F)...
October 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28992707/-overgrowth-in-children-and-in-adults-novel-clinical-view-novel-genes-novel-phenotypes
#15
Jan Lebl, Lukáš Plachý, Květa Bláhová, Lenka Elblová, Filip Fencl, Stanislava Koloušková, Štěpánka Průhová
Novel genetic findings allow to more reliably elucidate the aetiology and pathogenesis of overgrowth syndromes in children and in adults. The relatively prevalent overgrowth syndromes in foetuses and neonates include Beckwith-Wiedemann (BWS) and Sotos syndromes; in addition, several rare conditions may occur e.g. Simpson-Golabi-Behmel and Weaver syndromes. These syndromes are not connected with overproduction of growth hormone. Their carriers are at risk of hypoglycaemia (in BWS), of congenital malformations and of childhood tumours...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28979633/-rare-localization-of-aneurysmal-bone-cyst-in-the-sphenoid-bone
#16
Farida Abdoulkader, Kaoutar Aammou, Abdellatif Siwane, Fatiha Essodegui
Aneurysmal bone cyst is a benign tumor that can affect all bones in the body. It rarely affects the base of the skull. It is usually located at the level of the long bones. We report the clinical case of a 44-year old man treated for a mass in the basisphenoid wrongly diagnosed as invasive prolactin-producing macroadenoma for which he was put under dopamine agonists over a period of 9 months. We adjusted the diagnosis by suggesting aneurysmal bone cyst in the sphenoid bone on the basis of its almost pathognomonic radiological aspect on MRI...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28969203/remote-cerebellar-haemorrhage-occurring-after-transcranial-pituitary-surgery
#17
Numan Karaarslan, Mehmet Sabri Gürbüz, Tezcan Caliskan, Tamer Tunckale
Post supratentorial and spinal surgeries, in rare cases, Remote Cerebellar Haemorrhage (RCH) develops as a complication. Although the exact aetiology of RCH remains uncertain, excessive drainage of the Cerebrospinal Fluid (CSF) is accepted as the most possible cause. It has been suggested that overdrainage of CSF leads to stretching and resultantly tearing of the cerebellar veins. Early diagnosis and appropriate management decrease mortality and morbidity significantly. In this report, we present a case of RCH encountered on the third postoperative day of transcranial pituitary surgery and discuss the possible causative factors...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28954743/morbidity-and-mortality-in-patients-with-hyperprolactinaemia-the-prolears-study
#18
Enrique Soto-Pedre, Paul J Newey, John S Bevan, Graham P Leese
PURPOSE: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia. METHODS: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014 was performed. Record-linkage technology was used to identify patients with hyperprolactinaemia that were compared to an age-sex-matched cohort of patients free of hyperprolactinaemia...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28954263/beneficial-effects-of-high-doses-of-cabergoline-in-the-treatment-of-giant-prolactinoma-resistant-to-dopamine-agonists-a-case-report-with-a-21-year-follow-up
#19
Lucas Faria de Castro, Maria de Fátima Magalhães Gonzaga, Luciana Ansaneli Naves, José Luiz Mendonça, Benicio Oton de Lima, Luiz Augusto Casulari
INTRODUCTION: Prolactinomas are pituitary tumors with a very low prevalence in childhood and adolescence compared to adulthood. This condition is preferentially treated with dopamine agonists. Resistance to these drugs is rare. CASE REPORT: We describe the case of a boy diagnosed with macroadenoma at the age of 9 and followed up for 21 years. He did not fully respond to treatment with dopamine agonists. His initial prolactin level was 2,400 ng/mL (in males, normal values are <16...
September 26, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28951275/diagnosis-and-outcomes-of-341-patients-with-cushing-s-disease-following-transsphenoid-surgery-a-single-center-experience
#20
Ming Feng, Ziyuan Liu, Xiaohai Liu, Xinjie Bao, Yong Yao, Kan Deng, Bing Xing, Wei Lian, Huijuan Zhu, Lin Lu, Renzhi Wang
BACKGROUND: Transsphenoid surgery (TSS) is a standard treatment modality for Cushing's disease (CD). However, postoperative remission and recurrence rates vary among studies. Here we analyze the diagnosis and outcomes of 341 patients with a preoperative diagnosis of CD undergoing TSS in a single center over a 3-year period. METHODS: A total of 341 patients were enrolled. Clinical manifestations, imaging results, laboratory workups, and results of inferior petrosal sinus sampling (IPSS) were obtained...
September 23, 2017: World Neurosurgery
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