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testosterone in Ckd

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https://www.readbyqxmd.com/read/27647650/-andrologic-consequences-of-chronic-renal-failure-state-of-the-art-for-the-yearly-scientific-report-of-the-french-national-association-of-urology
#1
Y Neuzillet, R Thuret, F Kleinclauss, M-O Timsit
OBJECTIVE: To describe the state of the art of current knowledge regarding gonadal consequences of end-stage chronic kidney disease (CKD) and renal transplantation. MATERIAL AND METHOD: A systematic review of the literature search was performed from the databases Medline (NLM, Pubmed) and Embase, focused on the following keywords: "chronic kidney disease"; "chronic renal failure"; "hypogonadism"; "kidney transplantation"; "testicular dysfunction"; "testosterone"...
September 16, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/26858787/effect-of-adma-levels-on-severity-of-erectile-dysfunction-in-chronic-kidney-disease-and-other-risk-factors
#2
Kaan Gökçen, Hakan Kılıçarslan, Burhan Coşkun, Alparslan Ersoy, Onur Kaygısız, Yakup Kordan
INTRODUCTION: Hormonal, neurogenic, vasculogenic, and psychogenic impairments, as well as endothelial dysfunction may play a role in erectile dysfunction (ED) in patients with chronic kidney disease (CKD). Asymmetrical dimethylarginine (ADMA) is an inhibitor of nitric oxide, which is the key element of ED. ADMA levels are increased in CKD. We aimed to evaluate the effect of serum ADMA, prolactin, testosterone, and hemoglobin levels on erectile function of patients with CKD and control subjects...
January 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/26635963/testosterone-and-gonadotropins-but-not-shbg-vary-with-ckd-stages-in-young-and-middle-aged-men
#3
Britta Hylander, Mikael Lehtihet
BACKGROUND: The aim of this study was to assess the effects chronic kidney disease (CKD) had on sex hormones and lipids in a subgroup of men between 18 and 50 years old with CKD 1-5 stage without diabetes and not treated with hemodialysis. METHODS: Data were collected from 101 men with different CKD stages. RESULTS: Higher CKD stage (lower function) had a significant negative linear trend on total testosterone level (p < 0.01) and free testosterone level (p < 0...
2015: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/26452591/anti-m%C3%A3-llerian-hormone-a-sertoli-cell-derived-marker-is-decreased-in-plasma-of-male-patients-in-all-stages-of-chronic-kidney-disease
#4
D Eckersten, A Giwercman, L Bruun, A Christensson
Male patients with terminal renal failure are often infertile and exhibit an abnormal sex hormone pattern in plasma. We studied patients in all chronic kidney disease (CKD) stages to determine plasma levels of anti-Müllerian hormone (AMH), a Sertoli cell-derived marker, and other sex hormones. Seventy-eight male patients with CKD stages 1-5 and a median age of 40 years (22-50 years), as well as 20 healthy controls with a median age of 37 years (26-44 years), were enrolled. The CKD patients were evenly distributed; 18 with CKD stages 1-2, 19 with CKD stage 3, 19 with CKD stage 4, and 22 with CKD stage 5...
November 2015: Andrology
https://www.readbyqxmd.com/read/26275947/alpk1-affects-testosterone-mediated-regulation-of-proinflammatory-cytokines-production
#5
Tzer-Min Kuo, Kun-Tu Yeh, Hui-Ting Hsu, Shang-Lun Chiang, Jan-Gowth Chang, Chung-Ming Huang, Hung-Pin Tu, Chiu-Shong Liu, Ying-Chin Ko
Alpha-protein kinase 1, also known as alpha-kinase 1 (ALPK1), is associated with chronic kidney disease (CKD), myocardial infarction, gout and type 2 diabetes mellitus (DM). In addition to having an inductive effect on the proinflammatory cytokines in monocytic THP1 cells, ALPK1 is expressed abundantly in the mouse testes. Low testosterone levels are commonly associated with arthritis, CKD, type 2 DM, cardiovascular disease and inflammation. The testosterone's anti-inflammatory effect has been demonstrated to reduce proinflammatory cytokines and adhesion molecules...
November 2015: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26101371/prevalence-of-subnormal-testosterone-concentrations-in-men-with-type-2-diabetes-and-chronic-kidney-disease
#6
Sandeep Dhindsa, Anand Reddy, Jyotheen Sukhmoy Karam, Sayeeda Bilkis, Archana Chaurasia, Aditya Mehta, Keerthi P Raja, Manav Batra, Paresh Dandona
BACKGROUND: One-third of men with type 2 diabetes have subnormal testosterone concentrations along with inappropriately normal LH and FSH concentrations. It is not known if the presence of renal insufficiency affects free testosterone concentrations in men with type 2 diabetes. HYPOTHESIS: We hypothesized that type 2 diabetic men with chronic renal disease (CKD; estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m(2)) have lower free testosterone concentrations than men with normal renal function (eGFR ≥ 60 ml/min per 1...
September 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25910496/muscle-wasting-in-end-stage-renal-disease-promulgates-premature-death-established-emerging-and-potential-novel-treatment-strategies
#7
REVIEW
Peter Stenvinkel, Juan Jesus Carrero, Ferdinand von Walden, T Alp Ikizler, Gustavo A Nader
Muscle wasting (or sarcopenia) is a common feature of the uremic phenotype and predisposes this vulnerable patient population to increased risk of comorbid complications, poor quality of life, frailty and premature death. The old age of dialysis patients is in addition a likely contributor to loss of muscle mass. As recent evidence suggests that assessment of muscle strength (i.e. function) is a better predictor of outcome and comorbidities than muscle mass, this opens new screening, assessment and therapeutic opportunities...
July 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25780584/a-prospective-study-in-male-recipients-of-kidney-transplantation-reveals-divergent-patterns-for-inhibin-b-and-testosterone-secretions
#8
Safouane M Hamdi, Marie Walschaerts, Louis Bujan, Lionel Rostaing, Nassim Kamar
BACKGROUND: Male patients with chronic kidney disease often exhibit the biological and clinical hallmarks of an abnormal hypothalamo-pituitary-gonadal axis. It is known that dialysis does not reverse this impaired endocrine status; however, the impact of kidney transplantation (KT) is still controversial. The aim of our study was to investigate the levels of serum gonadotropins, testosterone, and inhibin B during dialysis and after KT. METHODS: A longitudinal and prospective single center study was led in an academic setting...
2014: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/25519210/evaluation-of-relationship-between-sexual-functions-depression-and-quality-of-life-in-patients-with-chronic-kidney-disease-at-predialysis-stage
#9
Bennur Esen, Serdar Kahvecioglu, Ahmet Engin Atay, Gulten Ozgen, Muhammed Masuk Okumus, Nurhan Seyahi, Dede Sit, Pınar Kadioglu
AIM: The relation of chronic kidney disease (CKD) with metabolic, psychiatric and endocrinologic disorder is well-known. Depressive mood and sexual dysfunction are frequently observed as renal functions deteriorate. We aimed to analyze the relationship of sexual dysfunction, depressive mood and life quality in patients with CKD at predialysis stage. PATIENTS AND METHODS: Fifty-three patients; 27 female and 26 male with CKD who had estimated glomerular filtration rate (eGFR) between 15 and 90 mL/min and followed up in the Nephrology Department, Bursa Sevket Yılmaz Education and Research Hospital, were enrolled...
March 2015: Renal Failure
https://www.readbyqxmd.com/read/25487067/semen-quality-in-men-with-chronic-kidney-disease-and-its-correlation-with-chronic-kidney-disease-stages
#10
M Lehtihet, B Hylander
The aim of this study was to assess whether chronic kidney disease (CKD) has any impact on semen quality parameters in men with CKD stage 1-5. Results were collected from 66 men with different CKD stages (age 18-50 years). Age and BMI (body mass index) were recorded for each male. Higher CKD stage had a significant negative linear trend on semen volume (P < 0.05), progressive motility (P < 0.01), nonprogressive motility (P < 0.001), sperm concentration (P < 0.01), total sperm number (P < 0.01), cytoplasmic droplets (P < 0...
December 2015: Andrologia
https://www.readbyqxmd.com/read/25378236/sex-steroids-levels-in-chronic-kidney-disease-and-kidney-transplant-recipients-associations-with-disease-severity-and-prediction-of-mortality
#11
Mathis Grossmann, Rudolf Hoermann, Mark Ng Tang Fui, Jeffrey D Zajac, Franscesco L Ierino, Matthew A Roberts
OBJECTIVE: Our objective was to characterize and evaluate prognostic implications of circulating sex steroids in patients at different stages of chronic kidney disease (CKD). DESIGN: Prospective observational cohort study. PATIENTS: We prospectively recruited patients with CKD III-IV, undergoing chronic dialysis and kidney transplant recipients (KTR) from a single centre in 2003-2004. MEASUREMENTS: Two stored samples taken 3 months apart were analysed for sex hormones using liquid chromatography/tandem mass spectrometry, and the mean of the two was used for analysis...
May 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25374815/chronic-kidney-disease-and-erectile-dysfunction
#12
REVIEW
Etsu Suzuki, Hiroaki Nishimatsu, Shigeyoshi Oba, Masao Takahashi, Yukio Homma
Erectile dysfunction (ED) is a common condition among male chronic kidney disease (CKD) patients. Its prevalence is estimated to be approximately 80% among these patients. It has been well established that the production of nitric oxide from the cavernous nerve and vascular endothelium and the subsequent production of cyclic GMP are critically important in initiating and maintaining erection. Factors affecting these pathways can induce ED. The etiology of ED in CKD patients is multifactorial. Factors including abnormalities in gonadal-pituitary system, disturbance in autonomic nervous system, endothelial dysfunction, anemia (and erythropoietin deficiency), secondary hyperparathyroidism, drugs, zinc deficiency, and psychological problems are implicated in the occurrence of ED...
November 6, 2014: World Journal of Nephrology
https://www.readbyqxmd.com/read/25219905/effect-of-erythropoietin-on-hepatic-cytochrome-p450-expression-and-function-in-an-adenine-fed-rat-model-of-chronic-kidney-disease
#13
D A Feere, T J Velenosi, B L Urquhart
BACKGROUND AND PURPOSE: Erythropoietin (EPO) is used to treat anaemia associated with chronic kidney disease (CKD). Hypoxia is associated with anaemia and is known to cause a decrease in cytochrome P450 (P450) expression. As EPO production is regulated by hypoxia, we investigated the role of EPO on P450 expression and function. EXPERIMENTAL APPROACH: Male Wistar rats were subjected to a 0.7% adenine diet for 4 weeks to induce CKD. The diet continued for an additional 2 weeks while rats received EPO by i...
January 2015: British Journal of Pharmacology
https://www.readbyqxmd.com/read/25209863/gender-differences-in-adenine-induced-chronic-kidney-disease-and-cardiovascular-complications-in-rats
#14
COMPARATIVE STUDY
Vishal Diwan, David Small, Kate Kauter, Glenda C Gobe, Lindsay Brown
Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) and associated cardiovascular disease. To induce kidney damage in male and female Wistar rats (n = 12/group), a 0.25% adenine diet for 16 wk was used. Kidney function (blood urea nitrogen, plasma creatinine, proteinuria) and structure (glomerular damage, tubulointerstitial atrophy, fibrosis, inflammation); cardiovascular function (blood pressure, ventricular stiffness, vascular responses, echocardiography) and structure (cardiac fibrosis); plasma testosterone and estrogen concentrations; and protein expression for oxidative stress [heme oxygenase-1, inflammation (TNF-α), fibrosis (transforming growth factor-β), ERK1/2, and estrogen receptor-α (ER-α)] were compared in males and females...
December 1, 2014: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/25193890/the-relation-between-serum-testosterone-levels-and-cardiovascular-risk-factors-in-patients-with-kidney-transplantation-and-chronic-kidney-disease
#15
Hulya Colak, Ismail Sert, Yusuf Kurtulmus, Cezmi Karaca, Huseyin Toz, Seyhun Kursat
The objective of the study is to evaluate the relationship between serum testosterone levels and cardiovascular risk factors (CVRF) in patients after kidney transplantation and with chronic kidney disease (CKD). Seventy-five male patients, aged between 18 and 68 years, who had kidney transplantation at least six months earlier, were enrolled into the study. Only renal transplant recipients and CKD patients with a creatinine level of <2.5 mg/dL were included in this study. Patients were divided into three groups as patients receiving calcineurine inhibitors (CNIs) and Mammalian target of rapamycin inhibitors (m-TORi) and CKD...
September 2014: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/25150851/testosterone-deficiency-at-the-crossroads-of-cardiometabolic-complications-in-ckd
#16
EDITORIAL
Juan Jesús Carrero
No abstract text is available yet for this article.
September 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/24804194/resistance-training-and-testosterone-levels-in-male-patients-with-chronic-kidney-disease-undergoing-dialysis
#17
MULTICENTER STUDY
Stig Molsted, Jesper L Andersen, Inge Eidemak, Adrian P Harrison, Niels Jørgensen
BACKGROUND: We investigated serum testosterone and insulin-like growth factor 1 (IGF-1) levels' associations with muscle fibre size and resistance training in male dialysis patients. METHODS: Male patients were included in a 16-week control period followed by 16 weeks of resistance training thrice weekly. Blood samples were obtained to analyse testosterone, luteinizing hormone (LH), IGF-1, and IGF-binding protein 3. Muscle fibres' size was analysed in biopsies from m...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24726629/serum-testosterone-levels-and-mortality-in-men-with-ckd-stages-3-4
#18
Kiranpreet K Khurana, Sankar D Navaneethan, Susana Arrigain, Jesse D Schold, Joseph V Nally, Daniel A Shoskes
BACKGROUND: Hypogonadism in men (total testosterone <350 ng/dL) is associated with higher risk of cardiovascular disease and mortality in men on dialysis therapy. We evaluated the association of hypogonadism with all-cause mortality in men with non-dialysis-dependent chronic kidney disease (CKD). STUDY DESIGN: Retrospective, cohort study. SETTING & PARTICIPANTS: 2,419 men with CKD stages 3-4 (estimated glomerular filtration rate, 15-59 mL/min/1...
September 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/24682292/effect-of-gender-differences-on-the-regulation-of-renal-ischemia-reperfusion-induced-inflammation-in-mice
#19
Kyung Pyo Kang, Jung Eun Lee, Ae Sin Lee, Yu Jin Jung, Dal Kim, Sik Lee, Hong Pil Hwang, Won Kim, Sung Kwang Park
Inflammation is a key mediator of renal ischemia-reperfusion (IR) injury. Gender disparities have been reported in acute and chronic kidney disease. In particular, males are considered to be more susceptible to renal ischemic injury compared with females according to animal studies. The purpose of the present study was to investigate the effect of gender on the renal inflammatory response following acute renal IR injury in mice. Experiments were performed in male and female C57BL/6 mice. Two weeks prior to the study, castration or ovariectomy were performed and testosterone propionate (100 µg/kg) or 17β-estradiol (100 µg/kg) was injected...
June 2014: Molecular Medicine Reports
https://www.readbyqxmd.com/read/24520983/sixteen-years-post-radiotherapy-of-nasopharyngeal-carcinoma-elicited-multi-dysfunction-along-ptx-and-chronic-kidney-disease-with-microcytic-anemia
#20
Yi-Ting Lin, Chia-Chun Huang, Charng-Cherng Chyau, Kuan-Chou Chen, Robert Y Peng
BACKGROUND: The hypothalamic-pituitary (h-p) unit is a particularly radiosensitive region in the central nervous system. As a consequence, radiation-induced irreversible, progressively chronic onset hypopituitarism (RIH) commonly develops after radiation treatments and can result in variably impaired pituitary function, which is frequently associated with increased morbidity and mortality. CASE PRESENTATION: A 38-year-old male subject, previously having received radiotherapy for treatment of nasopharygeal carcinoma (NPCA) 16 years ago, appeared at OPD complaining about his failure in penile erection, loss of pubic hair, atrophy of external genitalia: testicles reduced to 2×1...
2014: BMC Urology
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