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microalbuminuria glycemic control

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https://www.readbyqxmd.com/read/27885840/factors-associated-with-the-reduction-of-albumin-excretion-in-diabetic-hypertensive-patients-differential-effect-of-manidipine-versus-amlodipine
#1
Margarita Saiz-Satjes, Francisco Javier Martinez-Martin, Alex Roca-Cusachs
AIMS: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. METHODS: For this purpose, a multivariable analysis was performed. RESULTS: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine...
November 25, 2016: Future Cardiology
https://www.readbyqxmd.com/read/27879355/pregnancy-outcomes-in-women-with-diabetes-lessons-learned-from-clinical-research-the-2015-norbert-freinkel-award-lecture
#2
Elisabeth R Mathiesen
Among women with diabetes, the worst pregnancy outcome is seen in the subgroup of women with diabetic nephropathy. Development of severe preeclampsia that leads to early preterm delivery is frequent. Predictors and pathophysiological mechanisms for the development of preeclampsia among women with diabetes and observational studies that support antihypertension treatment for pregnant women with microalbuminuria or diabetic nephropathy preventing preeclampsia and early preterm delivery are presented here. Obtaining and maintaining strict glycemic control before and during pregnancy is paramount to prevent preterm delivery...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27797925/effect-of-saxagliptin-on-renal-outcomes-in-the-savor-timi-53-trial
#3
Ofri Mosenzon, Gil Leibowitz, Deepak L Bhatt, Avivit Cahn, Boaz Hirshberg, Cheryl Wei, KyungAh Im, Aliza Rozenberg, Ilan Yanuv, Christina Stahre, Kausik K Ray, Nayyar Iqbal, Eugene Braunwald, Benjamin M Scirica, Itamar Raz
OBJECTIVE: Dipeptidyl peptidase 4 inhibitors may have a protective effect in diabetic nephropathy. RESEARCH DESIGN AND METHODS: We studied renal outcomes of 16,492 patients with type 2 diabetes, randomized to saxagliptin versus placebo and followed for a median of 2.1 years in the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus Thrombolysis in Myocardial Infarction 53 trial. RESULTS: At baseline: 9,696 (58...
October 17, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27709487/long-term-outcomes-in-patients-with-morbid-obesity-and-type-1-diabetes-undergoing-bariatric-surgery
#4
Nuria Vilarrasa, Miguel Angel Rubio, Inka Miñambres, Lillian Flores, Assumpta Caixàs, Andrea Ciudin, Marta Bueno, Pedro Pablo García-Luna, María D Ballesteros-Pomar, Marisol Ruiz-Adana, Albert Lecube
BACKGROUND: This study aims to describe the long-term outcomes of bariatric surgery in a cohort of patients with type 1 diabetes (T1DM). METHODS: Thirty-two patients with T1DM and initial BMI of 41.3 ± 4.8 kg/m(2) were studied, 18.7 % undergoing duodenal switch (DS), 34.4 % gastric bypass, and 46.9 % sleeve gastrectomy and followed-up after surgery for 4.6 ± 2.6 years. Changes in BMI, HbA1c, insulin requirements, evolution of comorbidities, and microvascular complications were registered annually after surgery...
October 5, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27585521/persistent-insulin-resistance-in-podocytes-caused-by-epigenetic-changes-of-shp-1-in-diabetes
#5
Farah Lizotte, Benoit Denhez, Andréanne Guay, Nicolas Gévry, Anne Marie Côté, Pedro Geraldes
Poor glycemic control profoundly impacts protein expression and cell signaling action that contributes to glycemic memory and irreversible progression of diabetic nephropathy (DN). We have demonstrated that SHP-1 is elevated in podocytes of diabetic mice causing insulin unresponsiveness and DN. Thus, sustained SHP-1 expression caused by hyperglycemia despite systemic glucose normalization could contribute to the glycemic memory effect in DN. Microalbuminuria, GFR, mesangial cell expansion, collagen IV and TGF-β expression were significantly increased in diabetic Ins2(+/C96Y) mice compared to non-diabetic Ins2(+/+) mice and remained elevated despite glucose normalization with insulin implants...
September 1, 2016: Diabetes
https://www.readbyqxmd.com/read/27457509/diabetic-nephropathy-in-type-1-diabetes-a-review-of-early-natural-history-pathogenesis-and-diagnosis
#6
Nektaria Papadopoulou-Marketou, George P Chrousos, Christina Kanaka-Gantenbein
Diabetic nephropathy constitutes a devastating complication in patients with type 1 diabetes mellitus, and its diagnosis is traditionally based on microalbuminuria. The aim of this review is to update through the medical literature the suggested early natural course of diabetic nephropathy, the theories behind the pathways of its pathogenesis, and its diagnosis. Poor glycemic control, dyslipidemia, smoking, advanced glycation end products, and environmental and genetic clues play an important role in the development of diabetic nephropathy...
July 25, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27379223/cadmium-level-glycemic-control-and-indices-of-renal-function-in-treated-type-ii-diabetics-implications-for-polluted-environments
#7
John I Anetor, Chukwuemelie Z Uche, Emmanuel B Ayita, Solomon K Adedapo, Jokotade O Adeleye, Gloria O Anetor, Sola K Akinlade
Cadmium (Cd) has recently emerged as a major concern not only in environmental toxicology but also in metabolic diseases such as diabetes mellitus and its complications. Conflicting data aside, these studies have not been examined in a clinical population undergoing management as well as possible modulation by the prominent metabolic antagonist of Cd such as zinc (Zn). This study examined the relationship between cadmium levels, glycemic control, and renal pathology in established type II diabetic patients with focus on populations exposed to modern environmental health hazards (MEHHs)...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27275308/cardiovascular-autonomic-neuropathy-and-early-atherosclerosis-in-adolescent-type-1-diabetic-patient
#8
Soha M Abd El Dayem, Ahmed A Battah, Abo El Magd El Bohy
AIM: To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification. PATIENTS AND METHODS: It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. T-test, Mann Whitney U test, and stepwise multiple regression were used for statistical analyses...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27275296/study-of-adiponectin-level-in-diabetic-adolescent-girls-in-relation-to-glycemic-control-and-complication-of-diabetes
#9
Soha M Abd El Dayem, Hayam K Nazif, Mona Abd Ei-Kader, Maha El-Tawil
AIM: To study the relation between adiponectin level with glycemic control and complication of diabetes. PATIENTS AND METHODS: The study included 40 female adolescent type 1 diabetic patients and 40 healthy volunteers of the same age and sex. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile and adiponectine. Urine sample was taken for assessment of albumin/creatinine ratio. RESULTS: Diabetic patients had a significantly higher diastolic blood pressure, triglyceride, total cholesterol, LDL and adiponectin than controls...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27236773/circulating-angiopoietin-2-levels-in-children-and-adolescents-with-type-1-diabetes-mellitus-relation-to-carotid-and-aortic-intima-media-thickness
#10
Mohamed Abo El-Asrar, Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, AlShaimaa Abo Bakr
BACKGROUND: Angiopoietin-2 is a growth factor involved in the pathophysiology of vascular and inflammatory diseases such as arteriosclerosis. Carotid or aortic scans provide noninvasive screening tools for assessment of preclinical atherosclerosis in high-risk children. AIM: We assessed serum angiopoietin-2 in children and adolescents with type 1 diabetes mellitus as a potential marker for vascular complications in relation to glycemic control, inflammation and vascular structure...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/27226687/association-between-serum-uric-acid-urinary-albumin-excretion-and-glycated-hemoglobin-in-type-2-diabetic-patient
#11
Sunita Neupane, Raju Kumar Dubey, Narayan Gautam, Krishna Kumar Agrawal, Archana Jayan, Sujata Shrestha, Amit Chandra Jha
BACKGROUND: Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Poor glycemic control leads to diabetic complications. Hyperuricemia has been reported with increased risk of renal insufficiency. The aim of this study was to evaluate the relationship between serum uric acid concentration, degree of urinary albumin excretion (UAE) and glycated hemoglobin (HbA1c) in Type 2 DM (T2DM) patients. MATERIALS AND METHODS: Serum uric acid concentrations, urine microalbumin, and HbA1c were measured in fifty T2DM patients...
March 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27215237/the-association-between-glycemic-control-and-microalbuminuria-in-type-2-diabetes
#12
Anwar Ali Showail, Medhat Ghoraba
Microalbuminuria is an independent risk factor for cardiovascular and renal out- come in a patient with Type 2 diabetes. The evidence that intensive glycemic control reduces the microvascular complications of diabetes is based almost exclusively on prevention of micro- albuminuria. To evaluate the association between microalbuminuria and glycemic control and other factors in Type 2 diabetes, we studied retrospectively 551 patients with Type 2 diabetes. The patients were divided into two groups: 175 patients with microalbuminuria in the case group and 376 with normal urine albumin-creatinine ratio in the control group...
May 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27050468/insulin-pump-therapy-is-associated-with-lower-rates-of-retinopathy-and-peripheral-nerve-abnormality
#13
Bedowra Zabeen, Maria E Craig, Sohaib A Virk, Alison Pryke, Albert K F Chan, Yoon Hi Cho, Paul Z Benitez-Aguirre, Stephen Hing, Kim C Donaghue
OBJECTIVE: To compare rates of microvascular complications in adolescents with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI). RESEARCH DESIGN AND METHODS: Prospective cohort of 989 patients (aged 12-20 years; diabetes duration >5 years) treated with CSII or MDI for >12 months. Microvascular complications were assessed from 2000-14: early retinopathy (seven-field fundal photography), peripheral nerve function (thermal and vibration threshold testing), autonomic nerve abnormality (heart rate variability analysis of electrocardiogram recordings) and albuminuria (albumin creatinine ratio/timed overnight albumin excretion)...
2016: PloS One
https://www.readbyqxmd.com/read/27042419/diabcare-survey-of-diabetes-management-and-complications-in-the-gulf-countries
#14
Muhamed Shahed Omar, Khaled Khudada, Saher Safarini, Sherif Mehanna, Jalal Nafach
AIM: To describe the status of diabetes control and complications, and the quality of diabetes management in Saudi Arabia, Kuwait, and the United Arab Emirates, and to obtain an insight into the relationship between these factors. METHODS: Patients with diabetes for>12 months were enrolled from specialist clinics and general hospitals. All available data from the patients' medical files including patient demographics; glycemic, lipid, and blood pressure status; diabetes-related complications; and diabetes management were recorded in data collection forms and analyzed...
March 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27030792/targeted-quantification-of-n-1-carboxymethyl-valine-and-n-1-carboxyethyl-valine-peptides-of-%C3%AE-hemoglobin-for-better-diagnostics-in-diabetes
#15
Mashanipalya G Jagadeeshaprasad, Kedar B Batkulwar, Nishita N Meshram, Shalbha Tiwari, Arvind M Korwar, Ambika G Unnikrishnan, Mahesh J Kulkarni
BACKGROUND: N-1-(Deoxyfructosyl) valine (DFV) β-hemoglobin (β-Hb), commonly referred as HbA1c, is widely used diagnostic marker in diabetes, believed to provide glycemic status of preceding 90-120 days. However, the turnover of hemoglobin is about 120 days, the DFV-β-Hb, an early and reversible glycation product eventually may undergo irreversible advanced glycation modifications such as carboxymethylation or carboxyethylation. Hence quantification of N-1-(carboxymethyl) valine (CMV) and N-1-(carboxyethyl) valine (CEV) peptides of β-Hb would be useful in assessing actual glycemic status...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/27011945/association-of-comorbid-and-metabolic-factors-with-optimal-control-of-type-2-diabetes-mellitus
#16
Satyajeet Roy, Anthony Sherman, Mary Joan Monari-Sparks, Olga Schweiker, Navjot Jain, Etty Sims, Michelle Breda, Gita P Byraiah, Ryan George Belecanech, Michael Domenic Coletta, Cristian Javier Barrios, Krystal Hunter, John P Gaughan
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a poorly controlled epidemic worldwide that demands active research into mitigation of the factors that are associated with poor control. AIMS: The study was to determine the factors associated with suboptimal glycemic control. MATERIALS AND METHODS: Electronic medical records of 263 adult patients with T2DM in our suburban internal medicine office were reviewed. Patients were divided into two groups: Group 1 [optimal diabetes control with glycosylated hemoglobin (HbA1c) of 7% or less] and Group 2 (suboptimal diabetes control with HbA1c greater than 7%)...
January 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/26881259/characteristics-of-type-2-diabetes-with-ketosis-in-baoshan-yunnan-of-china
#17
Shichun Du, Xia Yang, Degang Shi, Qing Su
OBJECTIVES: The study provided data to demonstrate the characteristics of type 2 diabetes (T2D) with ketosis in rural parts of south-west border of China in order to help health professionals with optimizing diabetic care. METHODS: All hospitalized adult diabetic patients consecutively between January 2011 and July 2015 in Baoshan People's Hospital, Yunnan province of China, were evaluated. T2D with ketosis, ordinary T2D (without ketosis), and type 1 diabetes (T1D) patients were analyzed according to the clinical and biochemical parameters and chronic complications in these subjects...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26490431/unique-challenges-of-type-1-diabetes-in-the-preschool-population
#18
Loyal K Coshway, Robert P Hoffman
BACKGROUND: Extremely young children aged ≤6 years old represent a unique population among patients with type 1 diabetes in terms of glycemic variation, diabetes management and complications. OBJECTIVE: We describe distinct features of diabetes care and outcomes in preschool age children. METHODS: We searched PubMed, Google Scholar, and authors' bibliographies in order to extract articles specific to type 1 diabetes in preschool age children...
October 22, 2015: Current Diabetes Reviews
https://www.readbyqxmd.com/read/26470782/in-vivo-platelet-activation-and-aspirin-responsiveness-in-type-1-diabetes
#19
Francesco Zaccardi, Alessandro Rizzi, Giovanna Petrucci, Flavia Ciaffardini, Luigi Tanese, Francesca Pagliaccia, Viviana Cavalca, Angela Ciminello, Aida Habib, Isabella Squellerio, Paola Rizzo, Elena Tremoli, Bianca Rocca, Dario Pitocco, Carlo Patrono
Platelet activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 diabetes mellitus. We investigated in vivo thromboxane (TX) and prostacyclin (PGI2) biosynthesis and their determinants, as well as aspirin responsiveness, in young adult subjects with type 1 diabetes mellitus (T1DM) without overt cardiovascular disease and stable glycemic control. The biosynthesis of TXA2 was persistently increased in subjects with T1DM versus matched healthy subjects, with females showing higher urinary TX metabolite (TXM) excretion than male subjects with T1DM...
February 2016: Diabetes
https://www.readbyqxmd.com/read/26377593/high-hemoglobin-a1c-variability-is-associated-with-early-risk-of-microalbuminuria-in-children-with-t1d
#20
Sripriya Raman, Hongying Dai, Stephen A DeLurgio, David D Williams, Marcus Lind, Susana R Patton, John A Spertus, Mikhail Kosiborod, Mark A Clements
OBJECTIVE: To test the hypothesis that HbA1c variability, as measured by standard deviation (SD), is associated with increased risk for incident microalbuminuria and persistent microalbuminuria in pediatric type 1 diabetes (T1D). METHODS: A retrospective analysis using data from electronic health records was performed on 1195 patients from a pediatric diabetes clinic network in the Midwest USA from 1993 to 2009 with ≥1 yr of T1D, ≥4 total HbA1c values, ≥2 HbA1c values/yr, ≥1 urine microalbumin...
September 2016: Pediatric Diabetes
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