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Biological Psychiatry

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https://www.readbyqxmd.com/read/29427757/evaluation-of-the-extent-of-adaptation-to-sample-size-in-clinical-trials-for-cardiovascular-and-cns-diseases
#1
Sue-Jane Wang, Hua Peng, Hsien-Ming James Hung
A planned adaptation to sample size in an ongoing trial aims at providing an opportunity to modify design assumptions made at the trial planning stage. Reassessment of sample size in an ongoing trial may be performed in a non-comparative or a comparative fashion, either with or without use of external data that surface. We review the completed new drug applications (NDAs) and biologic license applications (BLAs) submitted since 2000 to cardio-renal, neurology and psychiatry drug products divisions of Center for Drug Evaluation and Research, U...
February 7, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29427067/individual-biological-sensitivity-to-environmental-influences-testing-the-differential-susceptibility-properties-of-the-5httlpr-polymorphism-in-relation-to-depressive-symptoms-and-delinquency-in-two-adolescent-general-samples
#2
Cecilia Åslund, Kent W Nilsson
The gene-environment interaction research field in psychiatry has traditionally been dominated by the diathesis-stress framework, where certain genotypes are assumed to confer increased risk for adverse outcomes in a stressful environment. In later years, theories of differential susceptibility, or biological sensitivity, suggest that candidate genes that interact with environmental events do not exclusively confer a risk for behavioural or psychiatric disorders but rather seem to alter the sensitivity to both positive and negative environmental influences...
February 9, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29408681/housing-environment-influences-stress-related-hippocampal-substrates-and-depression-like-behavior
#3
Archana Ashokan, Akshaya Nagrajan Hegde, Anushanthy Balasingham, Rupshi Mitra
Rats are widely used animal models for biological psychiatry and neuroscience. Laboratory rats are typically housed in impoverished sensory environments. The lack of species-typical sensory environment might radically change the response of individual animals to stressful and/or threatening episodes. In this report, we demonstrate that behavioral and neural sequelae of chronic stress were modified by sensory environment of adult male rats. This includes effects of stress on the density of spines on CA3 hippocampal neurons, hippocampal neurogenesis and abundance of glucocorticoid or mineralocorticoid receptors...
February 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29401044/machine-learning-approaches-for-clinical-psychology-and-psychiatry
#4
Dominic B Dwyer, Peter Falkai, Nikolaos Koutsouleris
Machine learning approaches for clinical psychology and psychiatry explicitly focus on learning statistical functions from multidimensional data sets to make generalizable predictions about individuals. The goal of this review is to provide an accessible understanding of why this approach is important for future practice because of its potential to augment decisions associated with the diagnosis, prognosis, and treatment of people suffering from mental illness using clinical and biological data. To this end, the limitations of current statistical paradigms in mental health research are critiqued, and an introduction is provided to the critical machine learning methods used in clinical studies...
January 29, 2018: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/29397661/the-present-and-future-of-precision-medicine-in-psychiatry-focus-on-clinical-psychopharmacology-of-antidepressants
#5
REVIEW
Alessandro Serretti
Precision medicine is a concept which is recently gaining momentum in all branches of medicine. In particular in psychiatry it is greatly needed given the huge societal costs of psychiatric disorders and given the long time needed to observe benefit from treatments and the response variability. The future will be based on biological determinants, however until such an interesting but still futuristic aim will be reached, at present we may only rely on clinical features to guide our individualized prescription which is currently still frequently based on personal opinion and subjective previous experiences...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29380713/a-pharmacopsychometric-overview-of-major-depressive-episodes-in-positive-psychiatry
#6
P Bech
BACKGROUND: The use of the pharmacopsychometric triangle to enhance patient-reported well-being as the ultimate goal of treatment has most intensively been studied in patients with a major depressive episode. METHODS: The review is structured on the pharmacopsychometric triangle in which the desired clinical effect of an antidepressive medication is balanced against the undesired side effects induced by this medication in terms of restored well-being. As a biological treatment, the antidepressive medication is compared clinically with both electroconvulsive therapy and psychological treatment...
January 30, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29368227/intertwining-personal-and-reward-relevance-evidence-from-the-drift-diffusion-model
#7
A Yankouskaya, R Bührle, E Lugt, M Stolte, J Sui
In their seminal paper 'Is our self nothing but reward', Northoff and Hayes (Biol Psychiatry 69(11):1019-1025, Northoff, Hayes, Biological Psychiatry 69(11):1019-1025, 2011) proposed three models of the relationship between self and reward and opened a continuing debate about how these different fields can be linked. To date, none of the proposed models received strong empirical support. The present study tested common and distinct effects of personal relevance and reward values by de-componenting different stages of perceptual decision making using a drift-diffusion approach...
January 24, 2018: Psychological Research
https://www.readbyqxmd.com/read/29363463/the-psychoexposome-a-holistic-perspective-beyond-health-and-disease
#8
María-Teresa Colomina, Fernando Sánchez-Santed, Nélida M Conejo, Paloma Collado, Alicia Salvador, Milagros Gallo, Helena Pinos, Cosme Salas, José F Navarro, Ana Adán, Arantza Azpiroz, Jorge L Arias
BACKGROUND: The concept of the exposome has emerged as a new strategy for studying all environmental exposures throughout an individual’s life and their impact on human health. Nowadays, electronic devices are available to collect data about an individual’s geolocation, biological function, or exposure biomarkers. The appearance of “omic” sciences and advances in bioinformatics have allowed massive data-gathering and analysis from various scientific fields. OBJECTIVE: to propose the term Psychoexposome in line with the concept of the exposome from the field of environmental sciences...
February 2018: Psicothema
https://www.readbyqxmd.com/read/29361992/brain-disorders-not-really%C3%A2-why-network-structures-block-reductionism-in-psychopathology-research
#9
Denny Borsboom, Angélique Cramer, Annemarie Kalis
In the past decades, reductionism has dominated both research directions and funding policies in clinical psychology and psychiatry. However, the intense search for the biological basis of mental disorders has not resulted in conclusive reductionist explanations of psychopathology. Recently, network models have been proposed as an alternative framework for the analysis of mental disorders, in which mental disorders arise from the causal interplay between symptoms. In this paper, we show that this conceptualization can help understand why reductionist approaches in psychiatry and clinical psychology are on the wrong track...
January 24, 2018: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/29352395/association-between-crp-genetic-diversity-and-bipolar-disorder-comorbid-complications
#10
Wahid Boukouaci, José Oliveira, Bruno Etain, Meriem Bennabi, Christina Mariaselvam, Nora Hamdani, Céline Manier, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer, Ryad Tamouza
BACKGROUND: Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute phase response molecule, C-reactive protein (CRP). While the genetic diversity of CRP was amply studied in various pathological settings, little is known in BD. METHODS: 568 BD patients along with 163 healthy controls (HC) were genotyped for the following single-nucleotide polymorphisms (SNPs) on the CRP gene: intron rs1417938 (+ 29) T/A, 3'-UTR rs1130864 (+ 1444) G/A, and downstream rs1205 (+ 1846) (C/T)...
January 20, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29351513/neuroimmune-interactions-from-the-brain-to-the-immune-system-and-vice-versa
#11
Robert Dantzer
Because of the compartmentalization of disciplines that shaped the academic landscape of biology and biomedical sciences in the past, physiological systems have long been studied in isolation from each other. This has particularly been the case for the immune system. As a consequence of its ties with pathology and microbiology, immunology as a discipline has largely grown independently of physiology. Accordingly, it has taken a long time for immunologists to accept the concept that the immune system is not self-regulated but functions in close association with the nervous system...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29340519/evaluating-the-current-state-of-the-art-of-huntington-disease-research-a-scientometric-analysis
#12
L A Barboza, N C Ghisi
Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed to examine the current state-of-the-art approaches that foster researchers' understandings of the current knowledge, research trends, and research gaps regarding this disorder. We performed literature searches of articles that were published up to September 2016 in the "ISI Web of Science™" (http://apps...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29310970/lithium-stress-and-resilience-in-bipolar-disorder-deciphering-this-key-homeostatic-synaptic-plasticity-regulator
#13
REVIEW
Rodrigo Machado-Vieira
BACKGROUND: Lithium is the lightest metal and the only mood stabilizer that has been used for over half a century for the treatment of bipolar disorder (BD). As a small ion, lithium is omnipresent, and consequently, its molecular mechanisms and targets are widespread. Currently, lithium is a crucial pharmacotherapy for the treatment of acute mood episodes, prophylactic therapy, and suicide prevention in BD. Besides, lithium blood level is the most widely used biomarker in clinical psychiatry...
December 22, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29307222/-professional-identity-of-hungarian-psychiatrist-experiences-of-a-study
#14
Adrienne Incze, Szabolcs Kéri, György Szekeres
INTRODUCTION: A main determinant of professional identity is the integrity of the discipline. The complexity of psychiatry in biological, psychological and sociological aspects is a typical instance of the necessity for integration. AIM: Based on the bio-psycho-social dimensions and on their opinion about acceptance of psychiatry, we explored the professional identities of physicians working in Hungarian contemporary psychiatry. METHOD: Voluntary, anonymous responses were collected by using a 10-point evaluation scale on professional attitude, appreciation of psychiatry from lay society and other medical professions, and the importance of biology, psychology and sociology within psychiatry...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29301639/genetic-testing-as-a-supporting-tool-in-prescribing-psychiatric-medication-design-and-protocol-of-the-impact-study
#15
Deanna Herbert, Maria Neves-Pereira, Ruth Baidya, Sheraz Cheema, Sarah Groleau, Anashe Shahmirian, Arun K Tiwari, Clement C Zai, Nicole King, Daniel J Müller, James L Kennedy
OBJECTIVE: Pharmacotherapy is one of the primary treatments for psychiatric disorders. Given the variation in individual response, a more personalized approach is needed. This paper will discuss methods for user-friendly referrals, recruitment criteria, data storage and dissemination, biological sample and clinical questionnaire collection, and advertising. METHODS: The Individualized Medicine: Pharmacogenetics Assessment and Clinical Treatment (IMPACT) study is one of the first to use pharmacogenetic testing on a large scale in psychiatry as a tool to predict individual drug response and tolerability...
September 27, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29289963/treatment-guidelines-for-circadian-rhythm-sleep-wake-disorders-of-the-polish-sleep-research-society-and-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association-part-ii-diagnosis-and-treatment
#16
REVIEW
Adam Wichniak, Konrad S Jankowski, Michał Skalski, Krystyna Skwarło-Sońta, Jolanta B Zawilska, Marcin Żarowski, Ewa Poradowska, Wojciech Jernajczyk
AIM: Circadian rhythm sleep-wake disorders (CRSWD) are a group of disorders, in which the timing of sleep and wakefulness significantly differs from a patient's expectations or socially acceptable times. The aimof the article is to present the current principles for the diagnosis and treatment of CRSWD in adults and children. METHOD: Guidelines proposed as CRSWD treatment standard are based on the recommendations from the scientific societies involved in the sleep research and medicine...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29289962/treatment-guidelines-for-circadian-rhythm-sleep-wake-disorders-of-the-polish-sleep-research-society-and-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association-part-i-physiology-assessment-and-therapeutic-methods
#17
REVIEW
Adam Wichniak, Konrad S Jankowski, Michal Skalski, Krystyna Skwarło-Sońta, Jolanta B Zawilska, Marcin Żarowski, Ewa Poradowska, Wojciech Jernajczyk
Majority of the physiological processes in the human organism are rhythmic. The most common are the diurnal changes that repeat roughly every 24 hours, called circadian rhythms. Circadian rhythms disorders have negative influence on human functioning. The aim of this article is to present the current understanding of the circadian rhythms physiological role, with particular emphasis on the circadian rhythm sleep-wake disorders (CRSWD), principles of their diagnosis and chronobiological therapy. The guidelines are based on the review of recommendations from the scientific societies involved in sleep medicine and the clinical experiences of the authors...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29246661/a-quantitative-approach-to-neuropsychiatry-the-why-and-the-how
#18
REVIEW
Martien J Kas, Brenda Penninx, Bernd Sommer, Alessandro Serretti, Celso Arango, Hugh Marston
The current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has stagnated. The recently EU-funded PRISM project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and development of better treatments. By combining clinical data sets from major worldwide disease cohorts and by applying innovative technologies to deeply phenotype stratified patient groups, we will define a set of quantifiable biological parameters for social withdrawal and cognitive deficits common to Schizophrenia (SZ), Major Depression (MD), and Alzheimer's Disease (AD)...
December 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29236813/psychoanalysis-and-neurosciences-fuzzy-outlines-notes-on-the-notion-of-cerebral-plasticity
#19
Maria Jimena Mantilla
"Psychoanalysis versus psychiatry" and "unconscious versus brain" are classic oppositions between different perspectives on the human being and mental suffering. This article draws on certain elements of this discussion and reflects on how new ideas about the brain and biology favor closer interaction between psychoanalysis and the neurosciences. These questions are redefined through the notion of cerebral plasticity, by which the brain is open to interaction with the social environment and the influence of psychoanalytical therapy...
November 2017: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29188348/-big-data-approaches-in-psychiatry-examples-in-depression-research
#20
REVIEW
D Bzdok, T M Karrer, U Habel, F Schneider
BACKGROUND: The exploration and therapy of depression is aggravated by heterogeneous etiological mechanisms and various comorbidities. With the growing trend towards big data in psychiatry, research and therapy can increasingly target the individual patient. This novel objective requires special methods of analysis. OBJECTIVE: The possibilities and challenges of the application of big data approaches in depression are examined in closer detail. MATERIAL AND METHODS: Examples are given to illustrate the possibilities of big data approaches in depression research...
November 29, 2017: Der Nervenarzt
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