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Keywords
evaluation and treatment of hy...
evaluation and treatment of hypertensive emergencies in adults
#21
JOURNAL ARTICLE
Giacomo d'Andrea, Stefania Chiappini, Roger S McIntyre, Giulia Stefanelli, Rosalba Carullo, Ileana Andriola, Raffaella Zanardi, Vassilis Martiadis, Stefano L Sensi, Gabriele Sani, Massimo Clerici, Giorgio Di Lorenzo, Antonio Vita, Mauro Pettorruso, Giovanni Martinotti
INTRODUCTION: Treatment-resistant depression (TRD) is a serious and debilitating psychiatric disorder that frequently affects older patients. Esketamine nasal spray (ESK-NS) has recently been approved as a treatment for TRD, with multiple studies establishing its efficacy and tolerability. However, the real-world effectiveness, tolerability, and safety of this treatment in older adults is still unclear. OBJECTIVES: To evaluate the efficacy and tolerability of ESK-NS in older subjects with TRD...
July 8, 2023: American Journal of Geriatric Psychiatry
#22
JOURNAL ARTICLE
Giorgio Gandaglia, Francesco Pellegrino, Asieh Golozar, Bertrand De Meulder, Thomas Abbott, Ariel Achtman, Muhammad Imran Omar, Thamir Alshammari, Carlos Areia, Alex Asiimwe, Katharina Beyer, Anders Bjartell, Riccardo Campi, Philip Cornford, Thomas Falconer, Qi Feng, Mengchun Gong, Ronald Herrera, Nigel Hughes, Tim Hulsen, Adam Kinnaird, Lana Y H Lai, Gianluca Maresca, Nicolas Mottet, Marek Oja, Peter Prinsen, Christian Reich, Sebastiaan Remmers, Monique J Roobol, Vasileios Sakalis, Sarah Seager, Emma J Smith, Robert Snijder, Carl Steinbeisser, Nicolas H Thurin, Ayman Hijazy, Kees van Bochove, Roderick C N Van den Bergh, Mieke Van Hemelrijck, Peter-Paul Willemse, Andrew E Williams, Nazanin Zounemat Kermani, Susan Evans-Axelsson, Alberto Briganti, James N'Dow
BACKGROUND: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. OBJECTIVE: To describe the clinical characteristics and long-term outcomes of PCa patients on conservative management by using an international large network of real-world data...
July 4, 2023: European Urology
#23
JOURNAL ARTICLE
Robert N Weinreb, William C Christie, Felipe A Medeiros, E Randy Craven, Kimmie Kim, Ashley Nguyen, Marina Bejanian, David L Wirta
OBJECTIVE: To evaluate the effects of a single bimatoprost implant administration on 24-hour intraocular pressure (IOP) lowering at 8 weeks, and 1-year IOP-lowering efficacy and safety outcomes. DESIGN: Multicenter, open-label, 12-month phase 3b study (NCT04285580). PARTICIPANTS: Adults with open-angle glaucoma or ocular hypertension. METHODS: Participants (n=31) received 10-μg bimatoprost implant in the study eye on day 1...
June 19, 2023: Ophthalmology Glaucoma
#24
JOURNAL ARTICLE
Zubaid Rafique, Jeffrey Budden, Carol Moreno Quinn, Youyou Duanmu, Basmah Safdar, Jason J Bischof, Brian E Driver, Charles A Herzog, Matthew R Weir, Adam J Singer, Stephen Boone, Karina M Soto-Ruiz, W Frank Peacock
INTRODUCTION: Hyperkalaemia is common, life-threatening and often requires emergency department (ED) management; however, no standardised ED treatment protocol exists. Common treatments transiently reducing serum potassium (K+ ) (including albuterol, glucose and insulin) may cause hypoglycaemia. We outline the design and rationale of the Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalaemia Management (PLATINUM) study, which will be the largest ED randomised controlled hyperkalaemia trial ever performed, enabling assessment of a standardised approach to hyperkalaemia management, as well as establishing a new evaluation parameter (net clinical benefit) for acute hyperkalaemia treatment investigations...
June 12, 2023: BMJ Open
#25
JOURNAL ARTICLE
Adriana Fernandes, Cláudio David, Fausto J Pinto, João Costa, Joaquim J Ferreira, Daniel Caldeira
BACKGROUND: Renal denervation (RDN) has emerged in recent years as a possible treatment for hypertension. The first sham-controlled trial showed a small magnitude and non-significant in the blood pressure (BP) lowering effect, also due to a substantial decrease of BP in sham arm. Considering this, we aimed to quantify the magnitude of BP decrease within the sham arm of Randomized Controlled Trials (RCT) with RDN in patients with hypertension. METHODS: Electronic databases were searched since inception until January 2022 for randomized sham-controlled trials which assessed the efficacy in lowering BP of the sham intervention for catheter-based RDN in adult patients with hypertension...
May 12, 2023: BMC Cardiovascular Disorders
#26
JOURNAL ARTICLE
Rémi Goupil, Annie-Claire Nadeau-Fredette, Bhanu Prasad, Gregory L Hundemer, Rita S Suri, William Beaubien-Souligny, Mohsen Agharazii
BACKGROUND: Emerging data favor central blood pressure (BP) over brachial cuff BP to predict cardiovascular and kidney events, as central BP more closely relates to the true aortic BP. Considering that patients with advanced chronic kidney disease (CKD) are at high cardiovascular risk and can have unreliable brachial cuff BP measurements (due to high arterial stiffness), this population could benefit the most from hypertension management using central BP measurements. OBJECTIVE: To assess the feasibility and efficacy of targeting central BP as opposed to brachial BP in patients with CKD G4-5...
2023: Canadian Journal of Kidney Health and Disease
#27
JOURNAL ARTICLE
Adam M Sonabend, Andrew Gould, Christina Amidei, Rachel Ward, Karyn A Schmidt, Daniel Y Zhang, Cristal Gomez, John F Bebawy, Benjamin P Liu, Guillaume Bouchoux, Carole Desseaux, Irene B Helenowski, Rimas V Lukas, Karan Dixit, Priya Kumthekar, Víctor A Arrieta, Maciej S Lesniak, Alexandre Carpentier, Hui Zhang, Miguel Muzzio, Michael Canney, Roger Stupp
BACKGROUND: Low-intensity pulsed ultrasound with concomitant administration of intravenous microbubbles (LIPU-MB) can be used to open the blood-brain barrier. We aimed to assess the safety and pharmacokinetics of LIPU-MB to enhance the delivery of albumin-bound paclitaxel to the peritumoural brain of patients with recurrent glioblastoma. METHODS: We conducted a dose-escalation phase 1 clinical trial in adults (aged ≥18 years) with recurrent glioblastoma, a tumour diameter of 70 mm or smaller, and a Karnofsky performance status of at least 70...
May 2023: Lancet Oncology
#28
JOURNAL ARTICLE
Abayomi Olabayo Oluwasanu, Joshua Odunayo Akinyemi, Mojisola Morenike Oluwasanu, Olabisi Bada Oseghe, Olusola Lanre Oladoyinbo, Jelili Bello, Ademola Johnson Ajuwon, Ayodele Samuel Jegede, Goodarz Danaei, Olufemi Akingbola
There is an increasing prevalence of obesity among college/university students in low- and middle-income countries, similar to the trend observed in high-income countries. This study aimed to describe the trend and burden of overweight/obesity and emerging associated chronic disease risks among students at the University of Ibadan (UI), Nigeria. This is a ten-year retrospective review of medical records of students (undergraduate and post-graduate) admitted between 2009 and 2018 at UI. Records of 60,168 participants were analysed...
2023: PloS One
#29
JOURNAL ARTICLE
Hunter Gillies, Ralph Niven, Benjamin T Dake, Murali M Chakinala, Jeremy P Feldman, Nicholas S Hill, Marius M Hoeper, Marc Humbert, Vallerie V McLaughlin, Martin Kankam
BACKGROUND: Oral imatinib has been shown to be effective, but poorly tolerated, in patients with advanced pulmonary arterial hypertension (PAH). To maintain efficacy while improving tolerability, AV-101, a dry powder inhaled formulation of imatinib, was developed to deliver imatinib directly to the lungs. METHODS: This phase 1, placebo-controlled, randomised single ascending dose (SAD) and multiple ascending dose (MAD) study evaluated the safety/tolerability and pharmacokinetics of AV-101 in healthy adults...
March 2023: ERJ Open Research
#30
JOURNAL ARTICLE
Mohamed Sheikh Hassan, Nor Osman Sidow, Alper Gökgül, Bakar Ali Adam, Mohamed Farah Osman, Hussein Hassan Mohamed, Ismail Gedi Ibrahim, Ishak Ahmed Abdi
INTRODUCTION: Neurologic disorders are common reasons for emergency consultations. Most neurologic disorders seen in the emergency department (ED) are life-threatening and require urgent treatment. The goal of this study is to investigate the pattern of neurological disorders among patients evaluated in the ED. METHODS: This is a cross-sectional study conducted in the ED of Mogadishu Somali Turkish Training and Research Hospital, from July 2021 to February 2022...
2023: Archives of Academic Emergency Medicine
#31
JOURNAL ARTICLE
Eric L Simpson, Melinda Gooderham, Andreas Wollenberg, Stephan Weidinger, April Armstrong, Jennifer Soung, Silvia Ferrucci, Renata Gontijo Lima, Michael M Witte, Wen Xu, Hany ElMaraghy, Chitra R Natalie, Evangeline Pierce, Andrew Blauvelt
IMPORTANCE: Lebrikizumab (LEB), a high-affinity monoclonal antibody targeting interleukin (IL)-13, demonstrated efficacy and safety in patients with moderate-to-severe atopic dermatitis (AD) during 16 weeks of monotherapy in a phase 2b trial, and two 52-week phase 3 trials. OBJECTIVE: To evaluate efficacy and safety of LEB combined with low- to mid-potency topical corticosteroids (TCS) in patients with moderate-to-severe AD. DESIGN, SETTING, AND PARTICIPANTS: The ADhere trial was a 16-week randomized, double-blinded, placebo (PBO)-controlled, multicenter, phase 3 clinical trial conducted from February 3, 2020, to September 16, 2021...
January 11, 2023: JAMA Dermatology
#32
JOURNAL ARTICLE
Matthew Scott Vandiver, Bhaswati Roy, Fahim Mahmud, Helen Lavretsky, Rajesh Kumar
BACKGROUND: Adults undergoing lung transplant, as a lifesaving treatment for end stage lung disease, exhibit high levels of peri-operative neurocognitive dysfunction in multiple domains, including delirium, cognition, and autonomic deficits. These complications impact healthcare costs, quality of life, and patient outcomes. Post-operative symptoms likely result from loss of brain tissue integrity in sites mediating such regulatory functions. Our aim in this study was to examine peri-operative neurocognitive dysfunction and brain tissue changes after lung transplant in adults...
2022: Frontiers in Cellular Neuroscience
#33
JOURNAL ARTICLE
Management of acute stroke among Lebanese patients: Assessing adherence to international guidelines.
Diana Malaeb, Sarah Cherri, Iqbal Fahs, Hala Sacre, Emane Abdallah, Pascale Salameh, Hassan Hosseini
BACKGROUND: Ischemic stroke accounts for around 87% of all strokes worldwide and is the second leading cause of mortality and a significant factor of disability in adults. The objective of this study was to assess the adherence to international treatment guidelines of ischemic stroke in Lebanese hospitals and evaluate factors associated with in-hospital mortality. METHODS: This retrospective observational study was conducted in three Lebanese hospitals between January 2018 and December 2019...
November 18, 2022: Current Drug Safety
#34
JOURNAL ARTICLE
Nadège Costa, Michael Mounie, Eugénie Gombault-Datzenko, Romain Boulestreau, Antoine Cremer, Marie C Delchier, Philippe Gosse, Séverine Lagarde, Benoit Lepage, Laurent Molinier, Panteleimon Papadopoulos, Hervé Trillaud, Hervé Rousseau, Béatrice Bouhanick
PURPOSE: Primary Aldosteronism (PA) is increasingly considered as a common disease affecting up to 10% of the hypertensive population. Standard of care comprises laparoscopic total adrenalectomy but innovative treatment such as RadioFrequency Ablation (RFA) constitutes an emerging promising alternative to surgery. The main aim of this study is to analyse the cost of RFA versus surgery on aldosterone-producing adenoma patient from the French National Health Insurance (FNHI) perspective...
November 15, 2022: Cardiovascular and Interventional Radiology
#35
JOURNAL ARTICLE
Ting-Yun Chiang, Yen-Kai Wang, Wen-Cheng Huang, Shiang-Suo Huang, Ya-Chun Chu
BACKGROUND: Cervical spondylotic myelopathy and chronic hypertension show a cause-effect relationship. Hypertension increases cardiovascular risk and is associated with intraoperative hypotension. We aimed to evaluate intraoperative hypotension in patients undergoing non-emergency decompression surgery for cervical spondylosis and its association with clinical myelopathy and chronic arterial hypertension. METHODS: This retrospective cohort study used healthcare data of adult patients undergoing cervical spine surgeries at Taipei Veterans General Hospital from 2015 to 2019...
2022: Frontiers in Medicine
#36
JOURNAL ARTICLE
Nabil Naser, Zaim Jatic, Sevleta Avdic
Background: Hypertension is the most important risk factor for cardiovascular morbidity and mortality. Blood pressure control rates are as low as 17% to 31% in patients diagnosed with hypertension in high-income countries; control rates are likely poorer in low- to middle- and low-income countries. Blood pressure control rates are as low as 17% to 31% in patients diagnosed with hypertension in high-income countries; control rates are likely poorer in low- to middle- and low- income countries...
June 2022: Materia Socio-medica
#37
JOURNAL ARTICLE
Arafat Ul Alam, M Dawn Goodyear, Cynthia Wu, Haowei Linda Sun
INTRODUCTION: Improvements in treatment strategies have led to increased life expectancy of persons with haemophilia (PWH). Consequently, age-related comorbidities become increasingly relevant. AIM: To evaluate the prevalence of age-related comorbidities, mortality, health service utilisation and predictors of hospitalisation in PWH compared to the general population. METHODS: We conducted a population-based retrospective cohort study using linked administrative data...
January 2023: Haemophilia: the Official Journal of the World Federation of Hemophilia
#38
JOURNAL ARTICLE
Kyla Wright, Mandana Mahmoudi, Nidhi Agrawal, Hope Simpson, Michael S Lui, H Leon Pachter, Kepal Patel, Jason Prescott, Insoo Suh
BACKGROUND: There is a bidirectional association between primary aldosteronism and obstructive sleep apnea, with evidence suggesting that the treatment of primary aldosteronism can reduce obstructive sleep apnea severity. Current guidelines recommend screening for primary aldosteronism in patients with comorbid hypertension and obstructive sleep apnea, identifying potential candidates for treatment. However, emerging data suggest current screening practices are unsatisfactory. Moreover, data regarding the true incidence of primary aldosteronism among this population are limited...
October 2, 2022: Surgery
#39
JOURNAL ARTICLE
Kelly G Knupp, Ingrid E Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine C Nickels, Lieven Lagae, Renzo Guerrini, Sameer M Zuberi, Rima Nabbout, Kate Riney, Anupam Agarwal, Michael Lock, David Dai, Gail M Farfel, Bradley S Galer, Arnold R Gammaitoni, Shikha Polega, Ronald Davis, Antonio Gil-Nagel
OBJECTIVE: To evaluate the long-term safety and effectiveness of fenfluramine in patients with Lennox-Gastaut syndrome (LGS). METHODS: Eligible patients with LGS who completed a 14-week phase 3 randomized clinical trial enrolled in an open-label extension (OLE; NCT03355209). All patients were initially started on 0.2 mg/kg/day fenfluramine and, after 1 month, were titrated to effectiveness and tolerability, which were assessed at 3-month intervals. The protocol-specified treatment duration was 12 months, but COVID-19-related delays resulted in 142 patients completing their final visit after 12 months...
October 5, 2022: Epilepsia
#40
JOURNAL ARTICLE
Mengist Awoke Yizengaw, Kisi Chemeda, Kabaye Kumela, Behailu Terefe Tesfaye
Background: Hypertensive emergency is associated with substantial complications and loss of life across the world. Early identification and treatment of hypertensive emergency complications are critical to prevent or avoid any consequences. Despite this, in Ethiopia, studies addressing mortality rate and its predictors as well as complications of hypertensive emergency are limited. Aims: This study aim to evaluate in-hospital mortality of patients admitted with a hypertensive emergency at the emergency ward of Jimma Medical Center...
September 2022: Health Science Reports
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